ライフサイエンスコーパス: primary tissue

1 igated clinically as a feasible surrogate to primary tissue.

2 assing neurogenesis and gliogenesis in human primary tissue.

3 unidentified roles in UC, were validated in primary tissue.

4 cape of centromeres in cancer cell lines and primary tissue.

5 en analyzed in metastatic tissue rather than primary tissue.

6 e in cell isolation from minimally processed primary tissue.

7 etic mechanisms underlying osteoarthritis in primary tissues.

8 al miR targeting data, particularly in human primary tissues.

9 rgets across a panel of human cell lines and primary tissues.

10 identify trans-eQTLs specific to one of four primary tissues.

11 secreted from essentially all cell types and primary tissues.

12 and their target genes among multiple human primary tissues.

13 usefulness of LCLs as a surrogate model for primary tissues.

14 regulatory genomic regions in cell lines and primary tissues.

15 ncreased p38gamma and MMP9 expression in the primary tissues.

16 that affects gene expression levels in human primary tissues.

17 in other expression contexts, such as human primary tissues.

18 expression levels in one or more of the five primary tissues.

19 ed and primary neural cells, and eight other primary tissues.

20 ine AtT-20 corticotroph cells and in several primary tissues.

21 Motor neurons are the primary tissue affected in SMA.

22 In both primary tissue and cell culture models, overexpression o

23 tein, B5, that is broadly expressed in human primary tissue and cell lines.

24 e resolution 5mCG and 5hmCG datasets from 20 primary tissue and cell samples to reveal relationships

25 cells and can potentially also be adapted to primary tissue and does not require any genetic engineer

26 eir basal fibres throughout mitosis, both in primary tissue and in older organoids.

27 differ from radial glial (RG) cells in both primary tissue and in stem cell-derived organoids.

28 ant infection in cortical astrocytes in both primary tissue and organoid cultures, with minimal infec

29 rotein are selectively expressed in specific primary tissues and cancer cell lines, and HEPL maintain

30 downregulation of the SFRP gene family in MM primary tissues and cell lines as well as several other

31 visualize Hi-C data generated from 21 human primary tissues and cell lines.

32 Organoids are derived from primary tissues and have the capacity for long-term grow

33 gene is unmethylated in telomerase-negative primary tissues and nonimmortalized cultured cells, indi

34 n-Fas complexes in B-cell lymphoma cells and primary tissues, and the absence of such complexes in B-

35 cities, how closely they resemble the target primary tissues, and the potential safety issues associa

36 tic processes in HFD mice indicates that the primary tissues are another facet of the immune system d

37 The genotype effects in the primary tissues are consistently in the same direction a

38 mapping of protein environment directly from primary tissue as well as the identification of interact

39 e CNV mutation is accessing DNA derived from primary tissues as opposed to cell lines.

40 is challenging to surmount in neurons, where primary tissue availability is poor.

41 r how precisely organoids recapitulate fetal/primary tissue biology.

42 e analysis of the immune microenvironment in primary tissue biopsy samples can be used to stratify pa

43 oncogenic mir-17-92 cluster was detected in primary tissues but also in blood from patients.

44 ingle-cell (clonogenic) cell population from primary tissue can differentiate into functional derivat

45 We quantify the degree primary tissue cell type marker expression and co-expres

46 By quantifying gene-level preservation of primary tissue co-expression, we show neural organoids l

47 Solid CRC tissues, either primary tissues collected from surgical specimens or xen

48 armonize cell annotations through mapping to primary tissue counterparts.

49 ectopic production of Myc or Ras proteins in primary tissue culture cells properly predict the activi

50 chromatid exchange at the frequency of 5% in primary tissue culture cells, whereas higher levels were

51 Primary tissue culture methods also are described, and t

52 Our studies demonstrate that this primary tissue culture system enables one to study gastr

53 We used a primary tissue culture system to generate a murine p53 n

54 on has not been fully defined in vivo and in primary tissue cultures.

55 spontaneously formed Mallory Denk bodies in primary tissue cultures.

56 gnal to co-expression indistinguishable from primary tissue, demonstrating a high degree of variabili

57 In 51 human primary tissues derived from normal prostate, benign pro

58 sent study demonstrates the utility of these primary tissue-derived cells for studying HCMV replicati

59 Primary tissue-derived epithelial organoids are a physio

60 Identifying the microbiome composition from primary tissues directly affords an opportunity to study

61 Three primary tissues, enamel (enameloid), dentin, and bone, a

62 e often advanced for evaluations using human primary tissue explants relevant to the in vivo mucosal

63 red productive ZIKV infection in HDB and GBM primary tissue explants that both contain SOX2+ neural p

64 tion of organoids with missing cell types or primary tissue explants.

65 e mucosal layer of conducting airways is the primary tissue exposed to inhaled microorganisms, allerg

66 readily available libraries of cell lines or primary tissues expressing fluorescent proteins and does

67 blinded physician readers identification of primary tissue features against comparative reader annot

68 Skeletal muscle is the primary tissue for glucose utilization, and insulin resi

69 nd maintaining energy homeostasis and is the primary tissue for insulin-stimulated glucose uptake.

70 st-effective method that could be applied to primary tissues for mapping global protein occupancies.

71 y a biodynamic phenotype that was similar to primary tissue from patients who had poor clinical outco

72 gical and immunohistological features of the primary tissue from which they were derived, including h

73 t UV-DDB is also deficient in cell lines and primary tissues from rodents.

74 that allow the long-term expansion of adult primary tissues from small intestine, stomach, liver and

75 ammalian cell lines differ from those of the primary tissues from which they were derived, exhibiting

76 ne promoters are frequently methylated in MM primary tissue (>80%).

77 cation of cis-acting regulatory variation in primary tissues has the potential to elucidate the genet

78 derived from human pluripotent stem cells or primary tissue have great potential to provide insights

79 sion levels across individuals in five human primary tissues (heart, kidney, liver, lung and testes).

80 le-cell RNA sequencing of both organoids and primary tissue identifies distinct venom-expressing cell

81 pigenetic landscape of infrapatellar fat pad primary tissue in osteoarthritis.

82 tinoblastoma tumor suppressor protein, using primary tissues in vivo, ex vivo, and in vitro, as well

83 ons in cell lines and organoids derived from primary tissues, including a clinically relevant Kras mu

84 nt in the mitochondria of cultured cells and primary tissues, including the liver and heart.

85 RNA blot analysis of mouse and human primary tissues indicated that both CTLA4 and T-cell rec

86 Analysis of primary tissues indicated that the TMS1 gene is unmethyl

87 n cell culture matched the amount of ACE2 in primary tissue, indicating that this feature of the inte

88 are characterized by different mechanisms of primary tissue injury that mostly affect lung.

89 has been hindered by limited availability of primary tissue, intraspecies variability associated with

90 rimary and secondary proteomes suggests that primary tissue is predictive of the metastatic phenotype

91 tory elements via open chromatin analysis of primary tissues is hindered by sample heterogeneity.

92 This study of glioblastoma cells and primary tissues is the first to implicate PDGF-C and -D

93 ted, the alpha subunits are secreted between primary tissue layers and become distributed in differen

94 and in early cell fate decisions leading to primary tissue layers during in vitro development of plu

95 ng, and differentiate into each of the three primary tissue layers.

96 pe A scavenger receptor-induced apoptosis in primary tissue macrophages and in macrophage apoptosis i

97 ptome sequencing on a discovery cohort of 18 primary tissue MCL samples and 2 cell lines.

98 kely to have a high expression of PD-L1 than primary tissue (OR = 3.13, 95% confidence interval = 1.0

99 MATCHY is especially suited to complex primary tissue-, organoid-, or biopsy-derived cell mixtu

100 In aspen stem primary tissues, PtCAD was immunolocalized exclusively t

101 2 diabetes mellitus, as skeletal muscle is a primary tissue responsible for glucose uptake.

102 Electron microscopic examination of primary tissues revealed intralesional accumulations of

103 We further analyzed DNA extracted from primary tissue samples and found the same pattern of CpN

104 rinting from allelic expression data in 1582 primary tissue samples from 178 individuals from the Gen

105 m14 and Mv(4;11) leukemia cells, but also in primary tissue samples from AML patients.

106 panel of breast cancer cell lines as well as primary tissue samples from breast cancer patients to in

107 sing murine Ba/F3 cells, human K562 cells or primary tissue samples from CML patients, whereas fmk tr

108 accessibility by sequencing (scATAC-seq) in primary tissue samples from the human forebrain.

109 enge; investigation using in vivo models and primary tissue samples is required to improve our in vit

110 g mutations of the c-kit gene occur in GCTs, primary tissue samples of 33 testicular and ovarian tumo

111 Here, we studied primary tissue samples to characterise human epicardium

112 Here, we used our trophoblast organoids and primary tissue samples to determine how uNK cells affect

113 the assay is applicable to small amounts of primary tissue samples with low protein synthesis rates,

114 vo, three-dimensional cultures prepared from primary tissue samples with minimal processing that reca

115 makes it suitable for large-scale studies in primary tissue samples.

116 d data, cell lines perturbed pathways and in primary tissues samples including The Cancer Genome Atla

117 onditions and is applicable for detection in primary tissue sections.

118 s detected in metastatic tissue or ctDNA and primary tissue sequencing was available for comparison.

119 achinery of the placenta thus represents the primary tissue site for regulating fetal Ca homeostasis.

120 Primary tissue specimens therefore appeared to be a bett

121 Using immunohistochemistry to analyze primary tissue specimens, we found that high SIRT1 expre

122 However, the primary tissue target remains unidentified.

123 Conversely, cancer cells and primary tissues that acquire resistance to 5-FU down-reg

124 The median (range) time from acquisition of primary tissue to acquisition of ctDNA or tumor tissue w

125 dels require systematic benchmarking against primary tissue to establish their value.

126 from women ages 16 to 91 years, derived from primary tissues, to investigate the molecular changes th

127 nformation capture (Hi-C) data from 11 human primary tissue types and 2 human cell lines.

128 bidopsis fruit comprises an ovary with three primary tissue types: the valves, the replum and the val

129 be specifically and sensitively detected in primary tissue using multiple colors.

130 me samples, e.g. clonally resolving archived primary tissues using scRNA-seq from metastases.

131 dependence on developmental stage or origin (primary tissue vs. stem cell), notable species-dependent

132 In applications to human cell models and primary tissue, we demonstrate the feasibility to detect

133 m molecular degradation experiments of human primary tissues, we introduce a method-quality surrogate

134 mbryogenesis and seed germination and is the primary tissue where gene imprinting occurs.

135 stromal cells in the microenvironment of the primary tissues wherein B-cell development occurs, ie, f

136 d to enrich for LP from formalin-fixed human primary tissues, which allowed the determination of mole

137 on onto adjacent proteins in fixed cells and primary tissues, which allows proteins in close proximit

138 of cell-specific gene expression patterns in primary tissues with a complex mixture of cell types.

139 t truncal events in prostate cancer and that primary tissue would faithfully reflect mutations found

140 hods for successful generation of short-term primary tissue xenografts from benign and tumor-derived