ライフサイエンスコーパス: primary-cultured

1 The absence of apoE expression in primary cultured adipocytes also leads to changes in the

2 se regulation of mRNA expression, we treated primary cultured adipocytes for 18 h with insulin (25 ng

3 cts spanning this region, and tested them in primary cultured and immortalized cells.

4 In primary cultured aortic VSMCs, catalase and diphenylenei

5 LP isoforms were constitutively expressed by primary cultured articular chondrocytes, but only CILP-1

6 Primary cultured astrocytes (glial fibrillary acidic pro

7 Primary cultured astrocytes exposed to 5 mm NH4Cl for di

8 e release of preloaded [3H]-D-aspartate from primary cultured astrocytes prepared from the cerebral c

9 onse to acute MeHg exposure in rat brain and primary cultured astrocytes to improve understanding of

10 Using primary cultured astrocytes, we show that loss of vesicu

11 ound by the phosphorylated forms of CRYAB in primary cultured astrocytes, we show that there is clear

12 activated caspase 3 and induced apoptosis in primary cultured astrocytes, which was prevented by casp

13 alent cation-sensitive permeation pathway in primary cultured astrocytes.

14 enous RA and RA production (from retinol) in primary cultured astrocytes.

15 In primary cultured BBMEC, TNF exposure resulted in an incr

16 Our previous studies in primary cultured beta cells suggested the presence of a

17 TNF-alpha augmented the contraction of primary cultured bladder smooth muscle cells through upr

18 recombinant murine HIMF induced migration of primary cultured bone marrow cells that was completely b

19 meability was evaluated both in vitro, using primary cultured bovine brain microvessel endothelial ce

20 ession of the various MRP homologues in both primary cultured bovine brain microvessel endothelial ce

21 In the second experiment, primary cultured bovine corneal epithelial cells were tr

22 PDGF on proliferation and ECM production by primary cultured bovine keratocytes were evaluated.

23 ositol 4,5-bisphosphate (PIP2) levels in the primary cultured cardiomyocytes from adult rats.

24 In primary cultured cardiomyocytes, chronic inhibition of P

25 trate phosphorylation and calcium cycling in primary cultured cardiomyocytes.

26 amples and in CECs (IOBA-NHC cell line, n=3; primary cultured CEC, n=3) exposed to 10 ng/mL IL-1beta

27 tiple QTL types in a highly disease-relevant primary cultured cell type and provide novel insights in

28 nal NAADP-sensitive Ca(2+) stores in a human primary cultured cell type.

29 are present at readily detectable levels in primary cultured cells and are not upregulated following

30 ew studies have explored these mechanisms in primary cultured cells expressing endogenous levels of r

31 Experiments were also done ex vivo and with primary cultured cells in vitro.

32 RPE primary cultured cells of the monkey also showed beta-CM

33 n N40 to several immortalized cell lines and primary cultured cells, including endothelial cells and

34 the ability to extend the life-span of these primary cultured cells, this system would be useful for

35 wth and pathogenesis in animal models and in primary cultured cells.

36 ors blocked focal adhesion assembly in these primary cultured cells.

37 highly similar sequences, using protein from primary cultured cells.

38 (+) tumor cell lines but to be attenuated in primary cultured cells.

39 iption-polymerase chain reaction (RT-PCR) in primary cultured cells.

40 ion of cell surface beta PP and integrins in primary cultured cells.

41 ficiency virus type 1 produced in vivo or by primary cultured cells.

42 rt of 5-formyltetrahydrofolate (5-FTHF) into primary cultured cerebellar granule cells (CGC) was stud

43 , lambda, theta, and zeta are present in rat primary cultured cerebellar granule cells (CGCs) 6-14 da

44 ch reproducible results can be obtained with primary cultured CGCs in the study of PKC.

45 in both sense and antisense orientations, on primary cultured chick calvarial osteoblasts.

46 Uptake of L-carnosine by primary cultured conjunctival epithelial cells in the pr

47 Two conjunctival epithelial cell lines and primary cultured conjunctival epithelial cells were trea

48 potential usefulness of cryopreserved human primary cultured corneal endothelial cells by characteri

49 Human primary cultured corneal endothelial cells retain their

50 fficient and nontoxic to cryopreserved human primary cultured corneal endothelial cells.

51 UT3 surface expression and glucose import in primary cultured cortical and hippocampal neurons.

52 aired its sorting into processes of PC12 and primary cultured cortical neuronal cells.

53 alpha was targeted to processes in wild-type primary cultured cortical neurons and PC12 cells but fai

54 stribution of beta-tubulin isotypes in mouse primary cultured cortical neurons from embryonic fetus,

55 efficiency of human TAT-sEH variants in rat primary cultured cortical neurons, associated with incre

56 brain and rapid activation by CART of ERK in primary cultured cortical neurons.

57 examined the regulation of ERK5 signaling in primary cultured cortical neurons.

58 ng the neuroprotective actions of statins in primary cultured cortical neurons.

59 lling-activated chloride current via VRAC in primary-cultured cortical astrocytes.

60 In contrast, immortalized and primary cultured cyst-lining epithelial cells from ADPKD

61 Moreover, primary cultured dopaminergic neurons from mesencephalon

62 Ninjurin2 promotes neurite outgrowth from primary cultured dorsal root ganglion neurons, presumabl

63 molecule and promotes neurite outgrowth from primary cultured DRG neurons.

64 We compared gene expression profiles of primary cultured ECs from human saphenous vein (SVEC) an

65 Primary cultured embryo fibroblasts from Gigyf2 null mic

66 Primary cultured endothelial cells and synoviocytes were

67 hence secretion of HCO(3)(-), we have loaded primary cultured endothelial cells derived from rat brai

68 R-126 upregulation increased angiogenesis of primary cultured endothelial cells from patients with de

69 Primary cultured endothelial cells from resistance arter

70 Primary cultured endothelial cells were dissociated from

71 he role of PDGF signaling in explant-derived primary cultured epicardial cells in vitro and in regene

72 In primary cultured esophageal epithelial cells, a region s

73 sufficient cell lines for a large scale HTS, primary cultured fibroblasts from MLD patients were tran

74 Primary cultured fibroblasts from the siblings showed no

75 lls, but not in the nuclei of tumor cells or primary cultured fibroblasts.

76 HGFs were primary cultured from human gingiva specimens.

77 Approximately 5 to 20% of lung fibroblasts primary cultured from injured wild-type mice were green

78 P-43 to stress granules in Hek293T cells and primary cultured glia.

79 A human glioma cell line, U-87MG, and primary cultured glioblastoma cells (MG-377) overexpress

80 In primary cultured hASM cells taken from normal donors, CX

81 sion level between young and older donors in primary cultured HCECs.

82 Gluconeogenesis is also increased in primary cultured hepatocytes derived from LAdrKO mice.

83 We have used primary cultured hepatocytes from the rat to investigate

84 did not trigger Ca2+ oscillations in either primary cultured hepatocytes or hepatocytes within the i

85 ess lipid accumulation in oleic acid-treated primary cultured hepatocytes relative to Them2(-/-) myot

86 phagy both in the in vivo mouse liver and in primary cultured hepatocytes.

87 uppressed by inhibition of the proteasome in primary cultured hepatocytes.

88 1 epitope is constitutively present in human primary cultured hepatocytes; however, its immunoreactiv

89 In primary, cultured hepatocytes and precision-cut liver sl

90 Using primary cultured HIMF-stimulated murine bone marrow cell

91 Using primary cultured hippocampal neurons (HNs) and rat pheoc

92 Most current methods of gene delivery for primary cultured hippocampal neurons are limited by toxi

93 , we inhibited F1Fo ATP synthase function in primary cultured hippocampal neurons by using non-lethal

94 Additionally, primary cultured hippocampal neurons expressing differen

95 Here, using transfected HEK-tsa cells and primary cultured hippocampal neurons from male and femal

96 Here, we were able to reproduce in primary cultured hippocampal neurons many of the effects

97 inhibitory postsynaptic currents (mIPSCs) in primary cultured hippocampal neurons, an effect opposite

98 brane pools, respectively, when expressed in primary cultured hippocampal neurons, consistent with pr

99 Primary cultured hRPE cells were incubated with various

100 Expression and activation of caspase-5 in primary cultured hRPE cells, telomerase-immortalized hTE

101 Primary cultured HSCs isolated from WT, SODmu, and NOX1

102 p53 genotype and occurs efficiently in some primary cultured human cells, indicating that the mutant

103 and efficacy of HAMs were investigated using primary cultured human corneal epithelial cells and vari

104 Primary cultured human corneal fibroblasts were exposed

105 studied in response to various treatments of primary cultured human esophageal epithelial cells and s

106 ssenger RNA (mRNA) and protein expression in primary cultured human hepatocytes, and stimulated MDR3

107 eta-inducible gene mRNA in HLE B-3 cells and primary cultured human lens cells from donor tissues.

108 The HLE B-3 cell line and primary cultured human lens cells respond similarly to T

109 d by both a human mast cell line (HMC)-1 and primary cultured human mast cells upon stimulation, wher

110 okines affect the degradation of Abeta using primary cultured human monocyte-derived macrophages (MDM

111 X2 is up-regulated in lungs, distal PAs, and primary cultured human PASMCs isolated from PAH and comp

112 Klotho protein (KL) is expressed in primary cultured human RPE, and regulates pigment synthe

113 cantly induced by all-trans-retinoic acid in primary cultured human tracheobroncheal epithelia.

114 programs of hypoxic ECs by using RNA-Seq of primary cultured human umbilical vein ECs exposed to pro

115 me, is toxic to endothelial cells, including primary cultured human umbilical vein endothelial cells

116 Cryopreserved, primary, cultured human corneal endothelial cells are vi

117 We demonstrated here that primary cultured IMFs bind staphylococcal enterotoxins i

118 after T. gondii infection using isolated and primary cultured intestinal cells from infected mice and

119 ucose-responsive transcriptional enhancer in primary cultured islet cells and as a transcriptional re

120 otein complex that is found in the nuclei of primary cultured islet cells, but not in the nuclei of t

121 tically reduces sequencing error, to analyze primary cultured isolates phenotypically resistant to ri

122 imary mouse embryonic fibroblasts (MEFs) and primary cultured kidney cells from 6-8 month-old DNA-PKc

123 KT restored normal Na+/K+-ATPase activity in primary cultured lens cells and reduced lens pressure in

124 Primary cultured Lewis (RT1.A(l)) hepatocytes were trans

125 Primary cultured limbal epithelial cells were transfecte

126 Primary cultured limbal epithelial cells were treated wi

127 Primary cultured lung fibroblasts prepared from both AT2

128 onstrate that monomeric Abeta degradation by primary cultured macrophages and microglia was significa

129 ies and glutathione levels were increased in primary cultured macular Muller cells which were more su

130 lated reporter-tagged Mbp mRNA granules from primary cultured mammalian oligodendrocytes to show that

131 FcepsilonRI-mediated signal transduction of primary cultured mast cells from Btk-, Lyn-, and Btk/Lyn

132 intestinal epithelial cell line), T84 cells, primary cultured mature human small intestinal epithelia

133 ion changes that occur during development of primary cultured megakaryocytes (MEG) and primary erythr

134 tions of HDAC3 to inflammasome activation in primary cultured microglia and experimental stroke model

135 Accordingly, primary cultured microglia from CD45-deficient mice demo

136 In vitro, murine wild-type primary cultured microglia responded to synthetic dsRNA

137 myloid (Abeta) peptides, we first co-treated primary cultured microglia with a tyrosine phosphatase i

138 Further, FGF2 enhances Abeta phagocytosis in primary cultured microglia, and reduces Abeta production

139 absent in melanoma 2 (AIM2) inflammasome in primary cultured microglia.

140 1 receptors, both receptors are expressed in primary cultured microglia.

141 Accordingly, primary cultured microglial cells from mice deficient in

142 0L-induced microglial activation, we treated primary cultured microglial cells with CD40L and anti-CD

143 cterized TDP-43 localization and dynamics in primary cultured motor neurons.

144 strong inhibitory effect on adipogenesis in primary cultured mouse ADSVFCs and human ADSCs.

145 We performed global expression profiling of primary cultured mouse and human macrophages, sampling a

146 Fabry disease, the caveolar lipid content of primary cultured mouse aortic endothelial cells isolated

147 and 1-120 amino acid N-terminal peptides in primary cultured mouse astrocytes.

148 expression profile of their synthases in the primary cultured mouse bone marrow derived macrophages (

149 These fusion proteins were expressed in primary cultured mouse brain astrocytes and arterial smo

150 n that store-operated Ca(2+) entry (SOCE) in primary cultured mouse cortical astrocytes occurs at pla

151 ve role against APAP-induced hepatotoxicity, primary cultured mouse hepatocytes and green fluorescent

152 In primary cultured mouse hepatocytes and HepG2 cells, the

153 various essential autophagy-related genes in primary cultured mouse hepatocytes and in mouse liver.

154 crosis factor alpha (TNFalpha) and sensitize primary cultured mouse hepatocytes to TNF-mediated apopt

155 en-induced necrotic and apoptotic killing of primary cultured mouse hepatocytes.

156 man HepaRG cells, rodent in vivo models, and primary cultured mouse hepatocytes.

157 Furthermore, primary cultured mouse motor neurons showed axonal degen

158 we examined PLN stability and degradation in primary cultured mouse neonatal cardiomyocytes (CMNCs) a

159 tected BID in the cytosol of mouse brain and primary cultured mouse neurons and demonstrated, by usin

160 In primary cultured mouse PASMCs loaded with fura-2, cyclop

161 The effects of supernatants from primary cultured mouse podocytes, before or after sublet

162 ocal measurements of intracellular Ca(2+) in primary cultured mouse skeletal myotubes reveal active s

163 We found primary cultured Muller cells from macula and peripheral

164 AVP stimulated GLP-1 and PYY release from primary cultured murine and human colonic cells and was

165 ctivin betaA mRNA was also highly induced in primary cultured murine bone marrow MC (BMMC) after stim

166 of TRAIL on IL-33 expression was assessed in primary cultured murine hepatocytes.

167 evels increased 10-fold within 24-48 h after primary cultured muscle cells; C2C12 mouse myoblasts or

168 uptake via AMPK in skeletal muscle cells and primary cultured myoblasts.

169 We show that in primary cultured myocytes most of the RAS is localized t

170 Experiments in primary cultured myofibroblasts by bulk-RNA sequencing,

171 Studies were conducted in primary cultured myotubes from beta1 knockout (KO), ryan

172 iments, conditioned medium collected from WT primary cultured myotubes promoted excess lipid accumula

173 croscopy was used to monitor Ca2+ signals in primary-cultured myotubes, prepared from forelimbs of wi

174 ety of neuronal cell lines (PC12, GT1-7) and primary cultured neurons (hippocampal, cortex).

175 microglia, and reduces Abeta production from primary cultured neurons after AAV2/1-FGF2 infection.

176 N1 protected primary cultured neurons against toxicity and cell death

177 duce the postsynaptic targeting of Shank2 in primary cultured neurons and alter glutamatergic synapti

178 We have replicated this observation in primary cultured neurons and demonstrate, by the accumul

179 d enhances aggregation of alpha-synuclein in primary cultured neurons and in dopaminergic neurons of

180 Here we demonstrate, in primary cultured neurons and the N2a neural cell line, t

181 y lower doses than those usually observed in primary cultured neurons and vascular smooth muscle cell

182 ated oxidative stress-mediated cell death in primary cultured neurons at nanomolar concentrations.

183 lular localization in immortalized cells and primary cultured neurons by immunocytochemistry and live

184 ta load in neuroblastoma cells as well as in primary cultured neurons derived from Tg2576 mice.

185 sease by 20 months of age, ALS2(-/-) mice or primary cultured neurons derived from these mice were mo

186 ke ibuprofen, promotes neurite elongation in primary cultured neurons exposed to axonal growth inhibi

187 HEK293) cells stably expressing the CB1R and primary cultured neurons expressing endogenous CB1R, we

188 t ubiquitination of endogenous Bax comparing primary cultured neurons from WT and parkin KO mice and

189 owever, the regulatory properties of ERK5 in primary cultured neurons have not been reported.

190 us (AAV) vectors for genetic manipulation of primary cultured neurons in vitro.

191 We show that increased E6AP expression in primary cultured neurons leads to a reduction in dendrit

192 ant channels in both neuroblastoma cells and primary cultured neurons revealed clear genotype-phenoty

193 ions for problems encountered when utilizing primary cultured neurons to study PKC-mediated signal tr

194 Furthermore, in primary cultured neurons, a proportion of UCH-L1(M) does

195 o mammalian-cultured cells, yeast, bacteria, primary cultured neurons, Drosophila melanogaster larval

196 In primary cultured neurons, NES mutations increase nuclear

197 l lines and trains of action potentials from primary cultured neurons.

198 t reticulocyte lysates, Xenopus oocytes, and primary cultured neurons.

199 This hypothesis was tested on primary cultured neurons.

200 he secretion of neurotoxic factors that kill primary cultured neurons.

201 entiated PC12 cells or serum withdrawal from primary cultured neurons.

202 res with synaptic targeting of Densin-180 in primary cultured neurons.

203 d by a G4-DNA ligand, pyridostatin (PDS), in primary cultured neurons.

204 ranscription regulators by depleting them in primary cultured neurons.

205 hagy markers levels in the SH-SY5Y cells and primary cultured neurons.

206 tide in multiple mammalian cell lines and in primary cultured neurons.

207 vation and reduced spine density and size in primary cultured neurons.

208 displayed activity in several cell lines and primary cultured neurons.

209 we performed a proteomic comparison between primary-cultured NPCs from the young adult and aged mous

210 sing a TMEM106B HeLa knock-out cell line and primary cultured oligodendrocytes, we determined that lo

211 Infection of primary cultured PASMCs with an adenoviral vector expres

212 Uptake of the dipeptide L-carnosine in primary cultured pigmented rabbit conjunctival epithelia

213 ce, and Synpo functions were investigated in primary cultured podocytes.

214 e have developed an in vitro BBB model using primary cultured porcine brain endothelial cells (PBECs)

215 slices from PS conditional knockout mice and primary cultured postnatal hippocampal neurons, in which

216 Primary-cultured PVPV-Akt1KO thyrocytes uniquely display

217 examine the expression of messenger RNAs in primary cultured rabbit and human lens cells and in ex v

218 -induced oxidant stress were investigated in primary cultured rabbit conjunctival epithelial cells (R

219 o define transport characteristics of GSH in primary cultured rabbit conjunctival epithelial cells (R

220 ivity in rabbit corneal epithelial (RCE) and primary cultured rabbit corneal epithelial (PRCE) cells

221 Primary cultured rabbit esophageal cells were loaded wit

222 are capable of inducing CYP3A expression in primary cultured rat and mouse hepatocytes and that the

223 ivity in transient transfection assays using primary cultured rat aortic SMCs.

224 sine kinase induces MMP-9 expression in both primary cultured rat aortic smooth muscle cells and in a

225 of the inducible NOS 5'-flanking region into primary cultured rat aortic smooth muscle cells and stim

226 gh levels of luciferase reporter activity in primary cultured rat aortic smooth muscle cells, and thi

227 niques to localize alpha subunit isoforms in primary cultured rat astrocytes, neurons, and arterial m

228 s a correlation of apoD's ability to protect primary cultured rat cardiomyocytes from hypoxia/reoxyge

229 In primary cultured rat cardiomyocytes, phenylephrine-induc

230 Primary cultured rat cerebellar granule neurons underwen

231 , potentiation and inhibition, on nnAChRs in primary cultured rat cortical neurons.

232 ssed with green fluorescent protein (GFP) in primary cultured rat dorsal root ganglion neurones (DRGs

233 re examined on cytochrome P450 expression in primary cultured rat hepatocytes and rat liver.

234 In vitro studies in primary cultured rat hepatocytes show that nontoxic conc

235 0/41) gene transcription was investigated in primary cultured rat hepatocytes transiently transfected

236 ted CYP3A mRNA induction was eliminated when primary cultured rat hepatocytes were cotreated with any

237 Primary cultured rat hepatocytes were transfected with s

238 Primary cultured rat hepatocytes were used to explore ke

239 eptor (PXR)-null mice, and cotransfection of primary cultured rat hepatocytes with a dominant-negativ

240 teric small arteries, and Ca2+ signalling in primary cultured rat hippocampal neurones.

241 cally transfected with ERalpha or ERbeta, in primary cultured rat hippocampal neurons in vitro and in

242 lysis, we have demonstrated the inability of primary cultured rat hippocampal neurons to induce a hea

243 tion of a heteromeric TRPV4-C1-P2 complex in primary cultured rat mesenteric artery endothelial cells

244 ent and inward Ca2+ current were recorded in primary cultured rat myoballs using the whole-cell confi

245 ines, and during in vitro differentiation of primary cultured rat oligodendrocytes.

246 dependently up-regulated TRPC6 expression in primary cultured rat PASMCs, and this was accompanied wi

247 nases (CDKs), Cdk2, Cdk3, Cdk4, and Cdk6, in primary cultured rat superior cervical ganglion sympathe

248 m apical fluid was significantly elevated in primary cultured RCECs treated for 24 hours with various

249 ) was examined after a 24-hour incubation of primary cultured RCECs with an NO donor, S-nitroso-N-ace

250 Kir2.3 inward rectifier K(+) channel in rat primary cultured reactive astrocytes.

251 Both immortalized and primary cultured renal epithelial cells that originate f

252 re we analyzed the localization of AQP2-4 in primary cultured renal inner medullary CD (IMCD) cells a

253 played a robust and punctate distribution in primary cultured retinal amacrine cells known to form ex

254 Primary cultured rodent adult cardiomyocytes were treate

255 In primary cultured rodent and human macrophages, CB1R acti

256 Using primary cultured Schwann cells, we analyze the upstream

257 Using primary cultured Sertoli cells as an in vitro model that

258 - tagged nebulin fragments were expressed in primary cultured skeletal myotubes.

259 on in modulating the level of PPIX, in human primary cultured skin fibroblasts (FEK4) maintained eith

260 e, we attempted to replicate this finding in primary cultured spinal cord neurons, spinal cord slice,

261 demonstrated that CD28 was also expressed by primary-cultured stromal cells that supported B lymphopo

262 o cells (a placental-trophoblast cell line), primary cultured trophoblasts, and human umbilical-vein

263 strand DNA breaks and decreases viability in primary cultured uroepithelial cells.

264 gnant human myometrial cell line PHM1-41 and primary cultured uterine myocytes responded to Toll-like