ライフサイエンスコーパス: primordial

1 bstantially improve the reliability of using primordial abundances to probe the physics of the early

2 of the origin of life there were only seven primordial amino acids: Valine (coded by GUX [X = U, C,

3 in gene expression and cellular functions in primordial and mature valves.

4 ely indicates that HAT-P-26b's atmosphere is primordial and obtained its gaseous envelope late in its

5 opulation at large, requires a redoubling of primordial and primary prevention efforts as declines in

6 The primordial approach focuses on social determinants of he

7 The primordial archaeal proteasome consists of a 20S proteol

8 This was not the case, however, in the primordial atmosphere, when abiotic reactions likely pla

9 n heavy xenon isotopes and matches that of a primordial atmospheric component.

10 use its abundance is highly sensitive to the primordial baryon density and also depends on the number

11 is widely believed to be a key reaction for primordial biology.

12 The distance to primordial bone thus plays a critical role for bone rege

13 d constituent tissues derived from different primordial cell lineages.

14 anding question in biology is how a group of primordial cells can give rise to complex organs.

15 ) catalyze replication of the RNA genomes of primordial cells.

16 e-impossible chemical transformations within primordial cells.

17 ed crustal evolution model; we find that the primordial clay is locally disrupted by impacts and buri

18 Furthermore, we explore the fate of a primordial clay-rich layer with the help of a parameteri

19 imization is most likely a by-product of the primordial code expansion driven by the diversification

20 PHA twisting led to torsion of the residual primordial common bulb, branching off to HA and CRA with

21 d the proto-Jupiter could have shattered its primordial compact core and mixed the heavy elements wit

22 aises the possibility that the plume hosts a primordial component.

23 at collagen IV and its variant, spongin, are primordial components of the extracellular microenvironm

24 Our work reveals the presence of a primordial CTD code within eukarya and indicates that pr

25 Although astronomical observations of primordial deuterium abundance have reached percent accu

26 chondritic meteorites and, by inference, the primordial disk from which they formed.

27 se Seckel syndrome (ATR-SS), a microcephalic primordial dwarfism disorder.

28 Similarly, primordial dwarfism in domesticated animals is linked to

29 me due to mutations in RNU4ATAC is linked to primordial dwarfism in microcephalic osteodysplastic pri

30 3-M primordial dwarfism is an inherited disease characterize

31 al dwarfism in microcephalic osteodysplastic primordial dwarfism type 1, Roifman syndrome, and Lowry-

32 Although the microcephaly- and primordial dwarfism-linked centrosomal protein CEP215 ha

33 uitin ligase, in patients with microcephalic primordial dwarfism.

34 itin ligase that is mutated in microcephalic primordial dwarfism.

35 te could have assumed these central roles on primordial Earth, given its poor geochemical accessibili

36 ted as an early form of energy metabolism on primordial Earth.

37 st accepted hypotheses for the conditions on primordial Earth.

38 FN fibrils are the primary component in primordial ECM and, as such, FN assembly is a critical c

39 Stipules and ligules: ontogeny of primordial elaborations 715 VII.

40 s engine is driven by unknown proportions of primordial energy and heat produced in radioactive decay

41 We postulate that sex-specific primordial energy optimisation strategies exist, which d

42 and set limits on the residual proportion of primordial energy.

43 lts suggest a mechanism for the emergence of primordial enzymes and highlight the potential of ancest

44 As theorized for primordial enzymes, the catalytic effects of the origina

45 e been used for nucleic acid biosynthesis by primordial enzymes, whose evolution then led to the use

46 systems retain latent abilities to revert to primordial Fe2+-based states when exposed to pre-GOE con

47 ume delta(15)N values may both be dominantly primordial features.

48 sent-day organisms retain some record of the primordial fluid in which the first cells formed.

49 Primordial follicle (PF) pool determines the availabilit

50 n with the unique characteristic of blocking primordial follicle activation that could be exploited t

51 has been proposed as a negative regulator of primordial follicle activation.

52 arian cells and unearths new insights during primordial follicle assembly in mice.

53 Primordial follicle assembly in the mouse occurs during

54 OR inhibition preserves the ovarian reserve, primordial follicle counts, serum anti-Mullerian hormone

55 otreatment, concomitant with preservation of primordial follicle counts.

56 varian insufficiency is chemotherapy-induced primordial follicle depletion, which has been proposed t

57 ole in perinatal germline cyst breakdown and primordial follicle formation by regulating E-cadherin j

58 rks that regulate oocyte differentiation and primordial follicle formation during early, postnatal mo

59 significantly suppressed cyst breakdown and primordial follicle formation in cultured mouse ovaries.

60 rane-impermeable BSA-conjugated P4 inhibited primordial follicle formation similar to that by P4.

61 Dazl determines primordial follicle formation through the translational

62 Progesterone (P4) inhibits primordial follicle formation under physiological condit

63 g is crucial for germline cyst breakdown and primordial follicle formation.

64 Physiologically, the size of the primordial follicle pool determines the reproductive lif

65 ility with major defects in stability of the primordial follicle pool, ovarian folliculogenesis, ovul

66 number and an increase in the proportion of primordial follicles (PMFs), with smaller oocytes within

67 ryonic exposure to ATZ reduces the number of primordial follicles and increases the incidence of mult

68 ads and performed lineage tracing to analyze primordial follicles and wave 1 medullar follicles durin

69 Global activation of primordial follicles in artificial ovaries can result in

70 We found significantly more primordial follicles in MIS-treated animals than in cont

71 an reserve represents the stock of quiescent primordial follicles in the ovary which is gradually dep

72 maturation approaches and support growth of primordial follicles in vitro.

73 The development of primordial follicles is controlled by a complex network

74 H) induced a greater proportion of quiescent primordial follicles than control ExECs, indicating supp

75 ggesting that the response in the oocytes of primordial follicles was dependent on cisplatin concentr

76 Its effects upon the progression of primordial follicles were assessed in cultures of mouse

77 f 5 mg/kg cisplatin: the death of oocytes in primordial follicles without indication of activation.

78 C57/Bl6 mouse ovaries densely populated with primordial follicles, CCND2 protein co-localised and was

79 Primordial follicles, consisting of granulosa cell (GC)-

80 h 2 mg/kg cisplatin for 15 days can activate primordial follicles, suggesting that the response in th

81 nalling in the maintenance and activation of primordial follicles, through SMAD-dependent and indepen

82 i, was ablated in mouse oocytes beginning in primordial follicles.

83 ia that support the growth and maturation of primordial follicles.

84 alian females, germ cells remain arrested as primordial follicles.

85 ontrol cell death pathways in the oocytes of primordial follicles.

86 BMP2-BMPR system leading to the formation of primordial follicles.

87 ferentiate into granulosa cells of quiescent primordial follicles.

88 The ovary contains oocytes within immature (primordial) follicles that are fixed in number at birth.

89 trauterine development had decreased ovarian primordial follicular reserve compared to controls (P <

90 Well-timed progression of primordial folliculogenesis is essential for mammalian f

91 lular survival of ER stress and represents a primordial form of innate immunity.

92 hat lack endocrine signaling, suggesting the primordial function may have been environmental sensing.

93 Here we investigated a potential primordial function of AceI and other members of the PAC

94 ch suggests that induction of autophagy is a primordial function of the cGAS-STING pathway.

95 Here we asked whether a primordial function, such as nucleic acid binding, could

96 umannii, suggesting that it has an important primordial function.

97 To investigate primordial fungal ecology, we performed amplicon sequenc

98 uced by conditional deletion of Sox17 in the primordial gallbladder epithelia but not in fetal liver

99 Gravitational collapse of a massive primordial gas cloud is a promising initial process, but

100 Its origin was ascribed to primordial gaseous O2 incorporated into the nucleus duri

101 d transcription factor SMAD3 is expressed in primordial GC nuclei alongside the cell cycle proteins,

102 alling, followed by a small increase in mean primordial GC number after 48 H.

103 ce by two successive duplication events of a primordial gene pair in the last common vertebrate ances

104 urrent understanding of the chemistry of the primordial genetic material is fragmentary at best.

105 The non-enzymatic replication of the primordial genetic material is thought to have enabled t

106 e cycles of non-enzymatic replication of the primordial genetic material may have been facilitated by

107 ancestry of distinct plant virus lineages to primordial genetic mobile elements.

108 NA and DNA building blocks in the same local primordial geochemical scenario.

109 hat sox7 plays a novel and important role in primordial germ cell (PGC) development and that ephrinB1

110 Primordial germ cell (PGC) development is characterized

111 al, Bmp and Smad downstream effectors during primordial germ cell (PGC) development.

112 ell-Less (GCL) protein is a key regulator of primordial germ cell (PGC) formation in Drosophila embry

113 mitochondria at the posterior at the site of primordial germ cell (PGC) formation through an actin-de

114 This repair process is essential for primordial germ cell (PGC) maturation during embryonic d

115 Two distinct mechanisms for primordial germ cell (PGC) specification are observed wi

116 imera formation and direct responsiveness to primordial germ cell (PGC) specification, a unique funct

117 hich they are competent for both somatic and primordial germ cell (PGC) specification.

118 erm plasm inheritance correlates with higher primordial germ cell (PGC) survival probability.

119 rospermatogonial specification whereby human primordial germ cell (PGC)-like cells differentiated fro

120 seq data collected during multiple stages of primordial germ cell and pre-implantation development, w

121 onserved regulators that are enriched at the primordial germ cell cytoplasmic bridge to ensure its st

122 marks present in parental chromosomes during primordial germ cell development and after fertilization

123 We highlight the importance to understand primordial germ cell development and the timing of gamet

124 found TE-specific endosiRNAs present during primordial germ cell development.

125 eprogramming occurs: early mouse embryos and primordial germ cell development.

126 TGCT susceptibility, consistent with failed primordial germ cell differentiation as an initiating st

127 embryonic stem cell pluripotency and promote primordial germ cell differentiation.

128 s of epiblast development for competency for primordial germ cell fate.

129 carcinoma cell resulting from a reprogrammed primordial germ cell from the thymus.

130 aneously initiate expression of mesoderm and primordial germ cell markers asymmetrically on the embry

131 Here we demonstrate, using primordial germ cell migration in mouse as a development

132 ignaling affects blastoderm cellularization, primordial germ cell positioning, and cuboidal-to-squamo

133 gene expression for markers of mesoderm and primordial germ cell precursors, and formation of anteri

134 esis that this molecular mechanism regulated primordial germ cell specification in a last common bila

135 found that ~3% of DNMs originated following primordial germ cell specification in a parent, and diff

136 ation, amniotic and yolk sac cavitation, and primordial germ cell-like cell (PGCLC) differentiation.

137 Pluripotent stem cell-derived human primordial germ cell-like cells (hPGCLCs) provide import

138 th previously reported ChIP-seq datasets for primordial germ cell-like cells and E18.5 small intestin

139 he three germ layers in chimeras and produce primordial germ cell-like cells in vitro.

140 ripotent and capable of differentiation into primordial germ cell-like cells.

141 We found that female human primordial germ cells (hPGCs) display reduced X-linked g

142 Human primordial germ cells (hPGCs), the precursors of sperm a

143 human germ-cell lineage originates as human primordial germ cells (hPGCs).

144 PRDM14 is a crucial regulator of mouse primordial germ cells (mPGCs), epigenetic reprogramming

145 a finch, we identified and characterized its primordial germ cells (PGCs) and compared them with chic

146 Diploid primordial germ cells (PGCs) are a potential means to fr

147 During embryonic gonad coalescence, primordial germ cells (PGCs) follow a carefully choreogr

148 The migration of primordial germ cells (PGCs) from their place of origin

149 In animals, primordial germ cells (PGCs) give rise to the germ lines

150 blastocysts, is also expressed in unipotent primordial germ cells (PGCs) in mice, where its precise

151 wrapping, we investigated niche wrapping of primordial germ cells (PGCs) in the C. elegans embryonic

152 nt/beta-catenin signaling pathway in chicken primordial germ cells (PGCs) in vitro.

153 The migration of primordial germ cells (PGCs) is a useful model for study

154 of a subset of mesodermal cells to form the primordial germ cells (PGCs) is restricted to the second

155 Caenorhabditis elegans primordial germ cells (PGCs) jettison mitochondria and c

156 We have profiled the transcriptome of primordial germ cells (PGCs) lacking the nanos homologs

157 During development, primordial germ cells (PGCs) navigate a complex journey

158 ritical chromatin modifications occur in the primordial germ cells (PGCs) of emergent starved L1 larv

159 eport that the translational activity in the primordial germ cells (PGCs) of the sea urchin embryo (S

160 In the developing embryo, primordial germ cells (PGCs) represent the exclusive pro

161 stem cell population arises from pluripotent primordial germ cells (PGCs) that enter the fetal testis

162 melanogaster requires directed migration of primordial germ cells (PGCs) towards somatic gonadal pre

163 These primordial germ cells (PGCs) undergo rapid proliferation

164 this study, the functional role of piwil2 in primordial germ cells (PGCs) was investigated in Nile ti

165 protein DND1 is required for the survival of primordial germ cells (PGCs), as well as the suppression

166 3 major processes: isolation and culture of primordial germ cells (PGCs), modification of the genome

167 obal, as seen in preimplantation embryos and primordial germ cells (PGCs), or locus specific, which c

168 m somatic lineages is the differentiation of primordial germ cells (PGCs), precursors of sex-specific

169 Primordial germ cells (PGCs), the founder cells of the g

170 evelopmental migration program of Drosophila primordial germ cells (PGCs), we show that cluster dispe

171 m naive pluripotency to the specification of primordial germ cells (PGCs).

172 ly precursors of the reproductive cells, the primordial germ cells (PGCs).

173 nt embryonic cells and, strikingly, to early primordial germ cells (PGCs).

174 onstruct to the DDX4 (vasa) locus in chicken primordial germ cells (PGCs).

175 ficially reconstructed by transplantation of primordial germ cells (PGCs).

176 Cs) provide important opportunities to study primordial germ cells (PGCs).

177 own to regulate the directional migration of primordial germ cells (PGCs).

178 with unmethylated cytosines is a hallmark of primordial germ cells (PGCs).

179 vivo transfection of plasmids in circulating Primordial Germ Cells (PGCs).

180 that global CpG methylation drops to 10% in primordial germ cells and 20% in the inner cell mass of

181 bipolar embryonic sac, and specification of primordial germ cells and gastrulating cells (or mesendo

182 em cells and induced pluripotent stem cells, primordial germ cells and oocytes.

183 bipolar embryonic sac, and specification of primordial germ cells and primitive streak cells.

184 cell factors, one we conclude represents the primordial germ cells and the other state is transiently

185 SPR/Cas9-mediated deletion of W38 in chicken primordial germ cells and the successful production of t

186 eage that converts to the germ line when the primordial germ cells are deleted.

187 h early embryogenesis and differentiation of primordial germ cells but is reduced substantially durin

188 endodermal cells interact with and regulate primordial germ cells by actively excising and digesting

189 ybrid (recipient) as an appropriate host for primordial germ cells from native poultry breeds.

190 Identification and characterization of primordial germ cells in a vocal learning Neoaves specie

191 itates the trans-epithelial migration of the primordial germ cells in early embryos.

192 nherited chromatin states transmitted to the primordial germ cells in offspring influence germline tr

193 meg-4) that does not assemble P granules in primordial germ cells loses competence for RNA-interfere

194 In the primordial germ cells of meg-3 meg-4 mutants, rde-11 and

195 highly efficient CRISPR/Cas9 gene editing in primordial germ cells represents a substantial addition

196 global view of cellular differentiation from primordial germ cells toward meiocytes.

197 nd in smaller, further differentiated cells (primordial germ cells), and their analysis using cell bi

198 e cells were formed without specification of primordial germ cells, epigenetic reprogramming or meios

199 ripotent stem cell differentiation into late primordial germ cells, meiotic germ cells and ovarian fo

200 r to epiblast, ectoderm, mesoderm, endoderm, primordial germ cells, trophectoderm, and amnion.

201 om the preceding epigenetic reprogramming in primordial germ cells.

202 ubule-dependent process; mRNAs necessary for primordial germ-cell formation are enriched in the germ

203 n Drosophila melanogaster and other animals, primordial germ-cell specification in the developing emb

204 A new study reveals that the primordial germline is a hideout for retrotransposon tra

205 em, tegument, oesophageal gland, parenchymal/primordial gut cells, and stem cells.

206 ever, the initial fungal colonization of the primordial gut remains undescribed.

207 Here, we describe fungal ecologies in the primordial gut that develop complexity with advancing ge

208 During phylogenetic development, the primordial habenula circuitry underwent various evolutio

209 ion with other mobatviruses, suggesting that primordial hantaviruses may have been hosted by ancestra

210 even time points spanning embryonic day 9.5 (primordial heart tube) to postnatal day 21 (mature heart

211 ance and color variation to a combination of primordial heterogeneity and varying exposure ages.

212 rm interkingdom microbial communities in the primordial human gut that develop with gestational age.

213 s of early lung development are expressed in primordial human lung progenitors and revealed a CD47hiC

214 interferon-inducible immunity and comprises primordial innate defense.

215 evention needs to start at an early age with primordial interventions at the population level.

216 which may serve as a model for a postulated primordial iron-sulfur world.

217 We propose that the primordial kinetochore evolved from proteins involved in

218 inhibitor and promotion of cell division at primordial leaf margins.

219 bserve bifurcating cell-fate trajectories as primordial lung progenitors differentiate in vitro, with

220 After sorting to purity, these primordial lung progenitors exhibited lung epithelial ma

221 PSCs) in vitro to generate and isolate human primordial lung progenitors that express NKX2-1 but are

222 Earth's primordial magma ocean cannot have contained less than 2

223 geophysical models and direct evidence for a primordial magnetic field in the rock record.

224 isional models based on the depletion of the primordial main belt of asteroids predict 10-15 craters

225 ese processes may explain why uncontaminated primordial mantle is so difficult to identify in recent

226 cean island basalts suggest the existence of primordial mantle signatures in the deep mantle.

227 on and laser-microdissection RNA-seq of leaf primordial margins to identify gene targets bound and mo

228 We also identified a primordial marker of carcinogenesis in a cancer-predispo

229 bably related to subducted oceanic plates or primordial material associated with Earth's formation.

230 pluripotent stem cells, the appropriation of primordial mechanisms of cell motility and invasion, and

231 ancestor of all eukaryotes and suggests that primordial meiosis may have had many characteristics in

232 ht to be assimilated by the urogenital sinus primordial mesenchyme in males during fetal development.

233 red from various standpoints as an idealized primordial metabolic cycle.

234 How primordial metabolic networks such as the reverse tricar

235 Thus, primordial metabolic pathways, already present in bacter

236 Given that such high fractions of primordial molecular cloud material are expected to surv

237 with that expected for thermally unprocessed primordial molecular cloud material before its pollution

238 ly complex and constrained by the relatively primordial nature of insect cell protein glycosylation p

239 The ratio of the two primordial neon isotopes, (20)Ne/(22)Ne, is significantl

240 ble that differential disruption of a common primordial neuropathological substrate causes these diff

241 The relative contribution of primordial nitrogen inherited during the Earth's accreti

242 he mantle may have retained remnants of such primordial nitrogen.

243 ring RNA and DNA synthesis and the origin of primordial nucleic acid biosynthesis.

244 ibonucleotides may have played a key role in primordial nucleic acids prior to the emergence of the c

245 tial rounds of intragenic duplication from a primordial one-domain precursor.

246 titutively active mutant PI3K was induced in primordial oocytes by Gdf9-iCre.

247 echanism of X-chromosome regulation in human primordial oocytes.

248 We report on the detection of primordial organic matter within the carbonaceous chondr

249 hondrite breccias found to date and contains primordial organic matter, probably originating in the i

250 atic and C=O bonding environments similar to primordial organics from other carbonaceous chondrites.

251 ical translation and furnish clues about its primordial origins.

252 mulations that include a realistic model for primordial oxygen isotopic reservoirs, our results favor

253 Glycolysis is one of the primordial pathways of metabolism, playing a pivotal rol

254 f peptidyl-RNAs, peptides, RNA oligomers and primordial phospholipids.

255 in the early pregnant uterus, containing the primordial placenta and embryo.

256 e-temperature states during the formation of primordial planetary bodies.

257 , we determine a (20)Ne/(22)Ne ratio for the primordial plume mantle of 13.23 +/- 0.22 (2 standard de

258 lyamines such as spermidine and spermine are primordial polycations that are ubiquitously present in

259 f viruses have been considered: descent from primordial, precellular genetic elements, reductive evol

260 Primordial prevention beginning in childhood and into ea

261 However, primordial prevention could have a substantial effect as

262 ity that public health initiatives targeting primordial prevention of obesity may reduce the incidenc

263 These findings suggest that both primordial prevention of risk factors and improved acute

264 Early primordial prevention strategies may contribute to reduc

265 gs support more effective LDL-C lowering for primordial prevention, even in individuals conventionall

266 provide opportunities for societal gains in primordial prevention.

267 ic Black women and in younger women (in whom primordial/primary prevention may be most effective).

268 g blocks of planets, that retain a record of primordial processes.

269 nique genetic program of in vivo murine lung primordial progenitors and computationally identify sign

270 models to generate in vitro engineered lung primordial progenitors from mouse pluripotent stem cells

271 Multipotent Nkx2-1-positive lung epithelial primordial progenitors of the foregut endoderm are thoug

272 usibly exist or at least have existed at the primordial protein stage.

273 e an important tool for tracing early-Earth, primordial reservoirs that have survived in the planet's

274 tenuation role of this pathway illuminates a primordial role for mitochondrial release of EndoG, and

275 eir degradation products constitutes a vital primordial role of SAA in innate immunity; this role rem

276 biology could have been formed under various primordial scenarios, and could therefore have contribut

277 rs instill a natural curiosity regarding the primordial selection and evolution of their corrin ligan

278 t some classes of viruses might descend from primordial selfish genetic elements, bona fide viruses e

279 ric' scenario under which different types of primordial, selfish replicons gave rise to viruses by re

280 ns, GCX, distinctly different from the other primordial Ser codon, AGY.

281 Histamine is a primordial signalling molecule, capable of activating ce

282 econdary heating processes that erased their primordial signature.

283 the occurrence of high (3)He/(4)He (that is, primordial) signatures in some volcanic rocks suggest th

284 Our study suggests that primordial SKI-1/S1P likely contained a simpler prodomai

285 nsembles from both amino acid mixtures and a primordial soup model.

286 We designed and conducted a series of primordial-soup Miller-Urey style experiments with deute

287 whereby the environment effectively directs "primordial soups" toward structure, function, and geneti

288 Thus, circulatory S1P confinement could be a primordial strategy of vertebrates in the development of

289 life's key building blocks from a handful of primordial substrates.

290 nderstanding of social signals is based on a primordial tendency to simulate observed actions by acti

291 eads to overgrowth of the jugular lymph sacs/primordial thoracic ducts, oedema and embryonic lethalit

292 Since these primordial times, the respiring mammalian cell has becom

293 Follicle development from primordial to preovulatory stage was characterized by 3

294 e growth is triggered at the transition from primordial to primary follicle and is accompanied by dyn

295 which was essential for the transition from primordial to primary follicle.

296 qual amounts of matter and antimatter in the primordial Universe after the Big Bang, but today's Univ

297 ient mesodermal cell state that predates the primordial vertebrate embryo.

298 the cellular regression, escaped genes, and primordial virus world hypotheses.

299 The primordial Xe component delivered to the Earth's atmosph

300 oupled with the distinct ratio of (129)Xe to primordial Xe isotopes in Yellowstone compared with mid-