ライフサイエンスコーパス: primordial germ cell

1 in four cell-stage embryos is specified as a primordial germ cell.

2 , axis determination, and development of the primordial germ cells.

3 y impairs SDF-1/CXCR4-dependent migration of primordial germ cells.

4 omotes active demethylation of the genome in primordial germ cells.

5 c and Tol2 transposons efficiently transpose primordial germ cells.

6 an trap and mutate endogenous transcripts in primordial germ cells.

7 ble elements for the genetic manipulation of primordial germ cells.

8 om the preceding epigenetic reprogramming in primordial germ cells.

9 acquired properties normally associated with primordial germ cells.

10 llectively called wunens, act redundantly in primordial germ cells.

11 ult body and perhaps to hold the fate of the primordial germ cells.

12 eterogeneous neoplasms thought to arise from primordial germ cells.

13 into the major somatic cell types as well as primordial germ cells.

14 enetic changes required for specification of primordial germ cells.

15 ressed Hro-nos appears to be associated with primordial germ cells.

16 s and consist of somatic cells and migratory primordial germ cells.

17 Because in mammals primordial germ cells also track through endoderm on the

18 conserved molecular program underlying both primordial germ cell and multipotent cell specification

19 seq data collected during multiple stages of primordial germ cell and pre-implantation development, w

20 that global CpG methylation drops to 10% in primordial germ cells and 20% in the inner cell mass of

21 ch has key parallels with those operating in primordial germ cells and early embryos.

22 bipolar embryonic sac, and specification of primordial germ cells and gastrulating cells (or mesendo

23 t to occur only twice during development, in primordial germ cells and in the pre-implantation embryo

24 fertility arises from a defect in migrating primordial germ cells and occurs equally in male and fem

25 em cells and induced pluripotent stem cells, primordial germ cells and oocytes.

26 bipolar embryonic sac, and specification of primordial germ cells and primitive streak cells.

27 ient vectors for the genetic manipulation of primordial germ cells and the chicken genome.

28 cell factors, one we conclude represents the primordial germ cells and the other state is transiently

29 SPR/Cas9-mediated deletion of W38 in chicken primordial germ cells and the successful production of t

30 pecific signal-receptor combinations between primordial germ cells and their immediate environment es

31 nd in smaller, further differentiated cells (primordial germ cells), and their analysis using cell bi

32 guishable cells of totipotent human embryos, primordial germ cells, and stable cell lines.

33 Hypomethylated primordial germ cells appear to limit this risk by expre

34 eage that converts to the germ line when the primordial germ cells are deleted.

35 In C. elegans, primordial germ cells are generated through four rounds

36 vasa and nanos orthologues, we find that the primordial germ cells are specified from at least the bl

37 New primordial germ cells arise from piwi-expressing germlin

38 Primordial germ cells arise from the proximal epiblast,

39 h early embryogenesis and differentiation of primordial germ cells but is reduced substantially durin

40 enome-wide demethylation that takes place in primordial germ cells, but leads to defective DNA demeth

41 quired for the colonization of the gonads by primordial germ cells, but not for earlier stages in ger

42 endodermal cells interact with and regulate primordial germ cells by actively excising and digesting

43 We demonstrate that chicken primordial germ cells can be modified in vitro using tra

44 DNA demethylation in postmigratory primordial germ cells coincides with erasure of genomic

45 onserved regulators that are enriched at the primordial germ cell cytoplasmic bridge to ensure its st

46 pletion caused by defective proliferation of primordial germ cells, decreased body weight, and partia

47 interrogate the epigenetic reprogramming of primordial germ cells, defining the timings of methylati

48 a germ-cell reporter to quantify and isolate primordial germ cells derived from both male and female

49 major body axes and for the localization of primordial germ cell determinants during Drosophila mela

50 ention that sea urchins do not have obligate primordial germ cells determined in early development, t

51 marks present in parental chromosomes during primordial germ cell development and after fertilization

52 g of the germ line are those associated with primordial germ cell development and subsequent fetal ge

53 We highlight the importance to understand primordial germ cell development and the timing of gamet

54 (Dnd1), an RNA-binding protein required for primordial germ cell development during later stages of

55 Primordial germ cell development uses programmed cell de

56 og revealed that it is essential for Gryllus primordial germ cell development, and is regulated by up

57 e essential for silencing transposons during primordial germ cell development, and MIWI-bound piRNAs

58 he kit receptor (Kit) is haplosufficient for primordial germ cell development.

59 found TE-specific endosiRNAs present during primordial germ cell development.

60 eprogramming occurs: early mouse embryos and primordial germ cell development.

61 thylation occur during the initial stages of primordial germ cell development; however, all consequen

62 TGCT susceptibility, consistent with failed primordial germ cell differentiation as an initiating st

63 embryonic stem cell pluripotency and promote primordial germ cell differentiation.

64 This is the first evidence for primordial germ cells displaying these behaviours in any

65 Through careful analyses of primordial germ cell distribution in developing Drosophi

66 as the zebrafish lateral line primordium and primordial germ cells, Drosophila border cell clusters,

67 required for the survival and maintenance of primordial germ cells during embryogenesis.

68 (meiotic) germline and in the development of primordial germ cells during embryogenesis.

69 required for the survival and maintenance of primordial germ cells during embryogenesis.

70 Such global reprogramming occurs in primordial germ cells, early embryos, and embryonic stem

71 blastocysts (embryonic stem cells, ESC) and primordial germ cells (embryonic germ cells, EGC).

72 e cells were formed without specification of primordial germ cells, epigenetic reprogramming or meios

73 The derivation of germ-line competent avian primordial germ cells establishes a cell-based model sys

74 Furthermore, primordial germ cells express, and appear to be function

75 s of epiblast development for competency for primordial germ cell fate.

76 Primordial germ cells first appear in extraembyronic tis

77 Using the in vivo model of zebrafish primordial germ cells for studying chemokine-directed si

78 Finally, we observed that modified primordial germ cells form functional gametes as demonst

79 Mouse primordial germ cells form germline cysts, but the role

80 nt, we reasoned that they might also support primordial germ cell formation.

81 ubule-dependent process; mRNAs necessary for primordial germ-cell formation are enriched in the germ

82 L (deleted in azoospermia-like) functions in primordial germ-cell formation, whereas closely related

83 carcinoma cell resulting from a reprogrammed primordial germ cell from the thymus.

84 raeus japonensis entails the regeneration of primordial germ cells from body parts that lack gonads.

85 ybrid (recipient) as an appropriate host for primordial germ cells from native poultry breeds.

86 We found that female human primordial germ cells (hPGCs) display reduced X-linked g

87 Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for developmen

88 Human primordial germ cells (hPGCs), the precursors of sperm a

89 human germ-cell lineage originates as human primordial germ cells (hPGCs).

90 Identification and characterization of primordial germ cells in a vocal learning Neoaves specie

91 itates the trans-epithelial migration of the primordial germ cells in early embryos.

92 We also propose a novel role for primordial germ cells in mediating coalescence of the Ca

93 nherited chromatin states transmitted to the primordial germ cells in offspring influence germline tr

94 velopment of both the abdominal segments and primordial germ cells in the Drosophila embryo.

95 ked the progeny of individual, newly arrived primordial germ cells in the E10.5 gonad.

96 metes is established by the proliferation of primordial germ cells in the early embryo.

97 erated with endogenous embryonic Sertoli and primordial germ cells in the generation of testicular co

98 mutagenesis with transplantation of mutated primordial germ cells into a wild-type host.

99 Over the first 4 days of their life, primordial germ cells invade the endoderm, migrate into

100 Formation of primordial germ cells is robust, but terminal gametogene

101 n of replicating mtDNA between proliferating primordial germ cells, is responsible for the different

102 gh they are also recruited to the germ line, primordial germ cells lacking Nanog fail to mature on re

103 ation, amniotic and yolk sac cavitation, and primordial germ cell-like cell (PGCLC) differentiation.

104 Pluripotent stem cell-derived human primordial germ cell-like cells (hPGCLCs) provide import

105 th previously reported ChIP-seq datasets for primordial germ cell-like cells and E18.5 small intestin

106 he three germ layers in chimeras and produce primordial germ cell-like cells in vitro.

107 ripotent and capable of differentiation into primordial germ cell-like cells.

108 elopmental stage prior to segregation of the primordial germ cell lineage at gastrulation.

109 meg-4) that does not assemble P granules in primordial germ cells loses competence for RNA-interfere

110 aneously initiate expression of mesoderm and primordial germ cell markers asymmetrically on the embry

111 ripotent stem cell differentiation into late primordial germ cells, meiotic germ cells and ovarian fo

112 other mammals and whether, in some species, primordial germ cells might be a more tractable source t

113 Primordial germ cell migration appeared normal within Ft

114 Here we demonstrate, using primordial germ cell migration in mouse as a development

115 ish deadend (dnd-MO-Vivo) effectively caused primordial germ cell mis-migration and differentiation i

116 PRDM14 is a crucial regulator of mouse primordial germ cells (mPGCs), epigenetic reprogramming

117 opmental cell migration, such as that of the primordial germ cells, occurred normally in the absence

118 olII-dependent transcription is repressed in primordial germ cells of many animals during early devel

119 In the primordial germ cells of meg-3 meg-4 mutants, rde-11 and

120 Interestingly, overexpression of p53 in primordial germ cells of out mutant embryos partially su

121 We show that primordial germ cells of the cricket Gryllus bimaculatus

122 hich only Ftm, Fto, and Fts are expressed in primordial germ cells of the early gonad.

123 triggers widespread chromosome damage in the primordial germ cells of the nematode C. elegans.

124 la is a novel gene specifically expressed in primordial germ cells, oocytes, preimplantation embryos,

125 cells derived from preimplantation embryos, primordial germ cells or teratocarcinomas are currently

126 ncb mutant mice were infertile and exhibited primordial germ cell (PGC) defects during embryogenesis.

127 P granules, do not appear to be required for primordial germ cell (PGC) determination [3], but their

128 hat sox7 plays a novel and important role in primordial germ cell (PGC) development and that ephrinB1

129 The 'last cell standing' model describes primordial germ cell (PGC) development in axolotls, in w

130 Primordial germ cell (PGC) development is characterized

131 al, Bmp and Smad downstream effectors during primordial germ cell (PGC) development.

132 le (F0 generation) progeny in regards to the primordial germ cell (PGC) epigenetic reprogramming of t

133 last cells that are already predisposed to a primordial germ cell (PGC) fate, which then progress to

134 ell-Less (GCL) protein is a key regulator of primordial germ cell (PGC) formation in Drosophila embry

135 mitochondria at the posterior at the site of primordial germ cell (PGC) formation through an actin-de

136 f embryonic stem cell (ESC) pluripotency and primordial germ cell (PGC) formation.

137 KitL, via its receptor cKit, supports primordial germ cell (PGC) growth, survival, migration a

138 This repair process is essential for primordial germ cell (PGC) maturation during embryonic d

139 by miRNAs that confers genetic robustness on primordial germ cell (PGC) migration.

140 g, how the methylation mark is erased during primordial germ cell (PGC) reprogramming remains unclear

141 nding of the molecular programs that control primordial germ cell (PGC) specification and differentia

142 ption factor BLIMP1 is a master regulator of primordial germ cell (PGC) specification and is suppress

143 Two distinct mechanisms for primordial germ cell (PGC) specification are observed wi

144 te model organisms on the molecular basis of primordial germ cell (PGC) specification have revealed t

145 amaki et al. identify T as a key mediator of primordial germ cell (PGC) specification in the embryo.

146 Primordial germ cell (PGC) specification is a universal

147 Primordial germ cell (PGC) specification occurs either b

148 imera formation and direct responsiveness to primordial germ cell (PGC) specification, a unique funct

149 monstrate that Blimp1, which is required for primordial germ cell (PGC) specification, is dispensable

150 aster germline determinant BLIMP1 to promote primordial germ cell (PGC) specification.

151 embryo, illustrate many typical features of primordial germ cell (PGC) specification.

152 allantois morphogenesis, cardiac looping and primordial germ cell (PGC) specification.

153 hich they are competent for both somatic and primordial germ cell (PGC) specification.

154 erm plasm inheritance correlates with higher primordial germ cell (PGC) survival probability.

155 edness to pluripotent stem cell (ESC, iPSC), primordial germ cell (PGC), and differentiated somatic r

156 lomes from mouse gametes, early embryos, and primordial germ cell (PGC), as well as single-base-resol

157 rospermatogonial specification whereby human primordial germ cell (PGC)-like cells differentiated fro

158 efective allantois formation and the lack of primordial germ cells (PGC), but also show phenotypes th

159 ads to failure in pole-plasm maintenance and primordial-germ-cell (PGC) formation, whereas doubling a

160 the formation of TFs and cap cells, anterior primordial germ cells (PGCs) adjacent to TFs/cap cells c

161 a finch, we identified and characterized its primordial germ cells (PGCs) and compared them with chic

162 de erasure of DNA methylation takes place in primordial germ cells (PGCs) and early embryos and is li

163 ing demethylation of DNA occurs in mammalian primordial germ cells (PGCs) and in early embryos, and i

164 end (dnd) mRNA is specifically expressed in primordial germ cells (PGCs) and is required for PGC mig

165 rentiating aggregates of cells that putative primordial germ cells (PGCs) and more mature gametes can

166 DNA methylation patterns need to be reset in primordial germ cells (PGCs) and preimplantation embryos

167 Primordial germ cells (PGCs) and preimplantation embryos

168 NA methylation reprogramming occurs in mouse primordial germ cells (PGCs) and preimplantation embryos

169 Drosophila melanogaster the proliferation of primordial germ cells (PGCs) and survival of the somatic

170 Diploid primordial germ cells (PGCs) are a potential means to fr

171 In Drosophila, primordial germ cells (PGCs) are set aside from somatic

172 or example, in Xenopus and zebrafish embryos primordial germ cells (PGCs) are specified by germ plasm

173 Primordial germ cells (PGCs) are the embryonic precursor

174 Primordial germ cells (PGCs) are the founder cells of th

175 Primordial germ cells (PGCs) are the precursors of sperm

176 Primordial germ cells (PGCs) are the precursors of sperm

177 Primordial germ cells (PGCs) are the progenitors of repr

178 orhabditis elegans larvae are starved, their primordial germ cells (PGCs) arrest in the post-S phase.

179 During gastrulation, primordial germ cells (PGCs) associate tightly with the

180 e stem cells (GSCs) descend from a subset of primordial germ cells (PGCs) at the onset of oogenesis.

181 anos protein expression is restricted to the primordial germ cells (PGCs) during early embryogenesis.

182 ential survival and proliferation factor for primordial germ cells (PGCs) during their migration in t

183 Mouse primordial germ cells (PGCs) erase global DNA methylatio

184 In the mouse embryo, significant numbers of primordial germ cells (PGCs) fail to migrate correctly t

185 During embryonic gonad coalescence, primordial germ cells (PGCs) follow a carefully choreogr

186 ximately 5% of human iPSCs differentiated to primordial germ cells (PGCs) following induction with bo

187 s study, we performed nuclear transfer using primordial germ cells (PGCs) from earlier stages at 8.5-

188 The migration of primordial germ cells (PGCs) from their place of origin

189 Primordial germ cells (PGCs) give rise to male and femal

190 Primordial germ cells (PGCs) give rise to the germ line

191 In animals, primordial germ cells (PGCs) give rise to the germ lines

192 es are deployed within this region, only the primordial germ cells (PGCs) have been closely studied.

193 inning at embryonic day 11.5 after migrating primordial germ cells (PGCs) have entered the gonad.

194 uires the specification and proliferation of primordial germ cells (PGCs) in an extragonadal location

195 , has a crucial role in the specification of primordial germ cells (PGCs) in mice at embryonic day 7.

196 blastocysts, is also expressed in unipotent primordial germ cells (PGCs) in mice, where its precise

197 wrapping, we investigated niche wrapping of primordial germ cells (PGCs) in the C. elegans embryonic

198 we tracked the distribution and migration of primordial germ cells (PGCs) in the Cx43alpha1KO mouse e

199 epends on the expansion of a small number of primordial germ cells (PGCs) in the early embryo.

200 e requires the specification and survival of primordial germ cells (PGCs) in the embryo as well as th

201 e rarity and inaccessibility of the earliest primordial germ cells (PGCs) in the mouse embryo thwart

202 patterns of Pt-vasa and Pt-piwi to show that primordial germ cells (PGCs) in the spider arise during

203 nt/beta-catenin signaling pathway in chicken primordial germ cells (PGCs) in vitro.

204 Primordial germ cells (PGCs) in Xenopus are specified th

205 egulation of migration initiation is that of primordial germ cells (PGCs) in zebrafish embryos.

206 ome activation (ZGA) and RNA localization in primordial germ cells (PGCs) in zebrafish.

207 dermal precursors, mesodermal precursors and primordial germ cells (PGCs) into the interior of the em

208 The migration of primordial germ cells (PGCs) is a useful model for study

209 The sex of primordial germ cells (PGCs) is determined in developing

210 of a subset of mesodermal cells to form the primordial germ cells (PGCs) is restricted to the second

211 ticular, the relationship between EpiSCs and primordial germ cells (PGCs) is unknown, and is worthy o

212 Caenorhabditis elegans primordial germ cells (PGCs) jettison mitochondria and c

213 We have profiled the transcriptome of primordial germ cells (PGCs) lacking the nanos homologs

214 Specification of primordial germ cells (PGCs) marks the beginning of the

215 During development, primordial germ cells (PGCs) migrate from the sites of t

216 These primordial germ cells (PGCs) migrate to the developing s

217 During development, primordial germ cells (PGCs) navigate a complex journey

218 ritical chromatin modifications occur in the primordial germ cells (PGCs) of emergent starved L1 larv

219 pressed in multipotent cells, stem cells and primordial germ cells (PGCs) of organisms as diverse as

220 eport that the translational activity in the primordial germ cells (PGCs) of the sea urchin embryo (S

221 nd the erasure of parental imprints in mouse primordial germ cells (PGCs) on embryonic day 11.5 (E11.

222 Ter)) results in a significant early loss of primordial germ cells (PGCs) prior to colonization of th

223 In the developing embryo, primordial germ cells (PGCs) represent the exclusive pro

224 ed from migrating 10.5-days-postcoitum (dpc) primordial germ cells (PGCs) showed normal morphological

225 ells (GSCs) in Drosophila are descendants of primordial germ cells (PGCs) specified during embryogene

226 stem cell population arises from pluripotent primordial germ cells (PGCs) that enter the fetal testis

227 During mouse development, primordial germ cells (PGCs) that give rise to the entir

228 melanogaster requires directed migration of primordial germ cells (PGCs) towards somatic gonadal pre

229 To acquire this property, primordial germ cells (PGCs) transit through an unpreced

230 hEG) cells derive from the transformation of primordial germ cells (PGCs) under appropriate culture c

231 Primordial germ cells (PGCs) undergo dramatic rearrangem

232 Primordial germ cells (PGCs) undergo proliferation, inva

233 These primordial germ cells (PGCs) undergo rapid proliferation

234 Mouse primordial germ cells (PGCs) undergo sequential epigenet

235 this study, the functional role of piwil2 in primordial germ cells (PGCs) was investigated in Nile ti

236 been suggested to mediate migration of early primordial germ cells (PGCs), a process that is little u

237 protein DND1 is required for the survival of primordial germ cells (PGCs), as well as the suppression

238 os from either GSCs or their precursors, the primordial germ cells (PGCs), causes both cell types to

239 istic insight on how the key determinants of primordial germ cells (PGCs), including Prdm14, induce r

240 3 major processes: isolation and culture of primordial germ cells (PGCs), modification of the genome

241 obal, as seen in preimplantation embryos and primordial germ cells (PGCs), or locus specific, which c

242 Blimp1 (Prdm1), the key determinant of primordial germ cells (PGCs), plays a combinatorial role

243 m somatic lineages is the differentiation of primordial germ cells (PGCs), precursors of sex-specific

244 two somatic gonad precursors (SGPs) and two primordial germ cells (PGCs), provides an accessible mod

245 ) results in mismigration and elimination of primordial germ cells (PGCs), resulting in fewer PGCs co

246 of Drosophila GSCs and their precursors, the primordial germ cells (PGCs), specifically requires CycB

247 Primordial germ cells (PGCs), the founder cells of the g

248 the gene expression profile between ESCs and primordial germ cells (PGCs), the founders of the germ c

249 Primordial germ cells (PGCs), the precursors of sperm an

250 In animals, specification of the primordial germ cells (PGCs), the stem cells of the germ

251 evelopmental migration program of Drosophila primordial germ cells (PGCs), we show that cluster dispe

252 n animal development is the specification of primordial germ cells (PGCs), which become the stem cell

253 Here we investigate Drosophila primordial germ cells (PGCs), which migrate through the

254 Genome-wide active DNA demethylation in primordial germ cells (PGCs), which reprograms the epige

255 ly embryos, embryonic stem cells (ESCs), and primordial germ cells (PGCs).

256 transcriptional program for pluripotency in primordial germ cells (PGCs).

257 vivo transfection of plasmids in circulating Primordial Germ Cells (PGCs).

258 ave been generated from both human and mouse primordial germ cells (PGCs).

259 ved from 11.5 or 12.5 days post coitum (dpc) primordial germ cells (PGCs).

260 ertional mutation leading to a deficiency of primordial germ cells (PGCs).

261 m naive pluripotency to the specification of primordial germ cells (PGCs).

262 ly precursors of the reproductive cells, the primordial germ cells (PGCs).

263 nt embryonic cells and, strikingly, to early primordial germ cells (PGCs).

264 onstruct to the DDX4 (vasa) locus in chicken primordial germ cells (PGCs).

265 ficially reconstructed by transplantation of primordial germ cells (PGCs).

266 Cs) provide important opportunities to study primordial germ cells (PGCs).

267 own to regulate the directional migration of primordial germ cells (PGCs).

268 with unmethylated cytosines is a hallmark of primordial germ cells (PGCs).

269 addition to functioning in proliferation of primordial germ cells, POG also functioned in spermatoge

270 sociated with cell cycle deficits within the primordial germ cell population that initiates just befo

271 ignaling affects blastoderm cellularization, primordial germ cell positioning, and cuboidal-to-squamo

272 Early primordial germ cells possess imprinting marks similar t

273 gene expression for markers of mesoderm and primordial germ cell precursors, and formation of anteri

274 We concluded that Rev7 is required for primordial germ cell proliferation and embryonic viabili

275 s detected, we report a critical decrease in primordial germ cell proliferation by E12.5.

276 highly efficient CRISPR/Cas9 gene editing in primordial germ cells represents a substantial addition

277 Specification of primordial germ cells requires global repression of tran

278 criptional and epigenetic landscape of human primordial germ cells, revealing a unique transcriptiona

279 tissue-specific gene expression of a set of primordial germ cell-specific genes.

280 esis that this molecular mechanism regulated primordial germ cell specification in a last common bila

281 found that ~3% of DNMs originated following primordial germ cell specification in a parent, and diff

282 M, a linker histone-like protein involved in primordial germ cell specification, zinc finger protein,

283 n Drosophila melanogaster and other animals, primordial germ-cell specification in the developing emb

284 Mutations in p53 result in excess primordial germ cells that are ectopic to the gonads.

285 methylation has been observed in zygotes and primordial germ cells, the responsible enzyme(s) have be

286 P expression was observed in the blastocyst, primordial germ cells, thymus, arterioles, osteoblasts,

287 vy chain gene by homologous recombination in primordial germ cells to establish fully transgenic chic

288 d to maintain stem cell pluripotency and for primordial germ cells to retain proliferative capability

289 global view of cellular differentiation from primordial germ cells toward meiocytes.

290 r to epiblast, ectoderm, mesoderm, endoderm, primordial germ cells, trophectoderm, and amnion.

291 Before the initiation of meiosis, mouse primordial germ cells undergo a series of epigenetic rep

292 Current methods to modify primordial germ cells using DNA or retroviral vectors ar

293 ell lines can also be derived from unipotent primordial germ cells via a poorly understood process of

294 on cells, such as the founder population of primordial germ cells where rapid and dynamic changes oc

295 developing into reproductive larvae possess primordial germ cells whereas embryos developing into so

296 pha severely reduces the number of embryonic primordial germ cells, which require Oct-4 expression fo

297 More generally, gene targeting in avian primordial germ cells will foster advances in diverse fi

298 el, results in severely decreased numbers of primordial germ cells within the early gonad.

299 n of both the somatic gonadal precursors and primordial germ cells within the primordium, but does no

300 PIE-1 disappears upon the birth of the primordial germ cells Z2 and Z3, yet these cells appear