ライフサイエンスコーパス: privilege

1 am superior to others" and "I am entitled to privileges").

2 ique catalyst scaffold may become viewed as "privileged".

3 ce, an area typically associated with immune privilege.

4 in the brain and can readily overcome immune privilege.

5 ls the metabolic landscape to support immune privilege.

6 d, we have reevaluated the concept of immune privilege.

7 ort RS cell survival and foster their immune privilege.

8 immunotherapy approaches to overcome immune privilege.

9 lls into PDAC and establish a site of immune privilege.

10 The brain is a site of relative immune privilege.

11 idents of census tracts without such current privilege.

12 that promotes corneal immune- and angiogenic-privilege.

13 al staff or providers who are requesting new privileges.

14 The first syntheses of privileged [5,6]-bicyclic heterocycles, with ring-juncti

15 rted gaze, thus providing a neural basis for privileged access of direct gaze to awareness.

16 studied the neural mechanisms underlying the privileged access of direct gaze to visual awareness.

17 Here, we test the hypothesis that this privileged access shapes the way people represent intern

18 d cortisol enables emotional stimuli to gain privileged access to amygdala-hippocampus circuits, even

19 We report that fearful faces gain privileged access to awareness over angry faces, but tha

20 re prioritised by the visual system and gain privileged access to awareness over other expressed emot

21 o the idea that the oculomotor periphery has privileged access to short-latency visual signals.

22 n, such as the superior colliculus, may have privileged access to visual form information.SIGNIFICANC

23 such as the superior colliculus, likely have privileged access to visual object representations.

24 these data demonstrate that screams occupy a privileged acoustic niche that, being separated from oth

25 standing of mechanisms underlying CNS immune privilege and CNS drainage.

26 hnic and economic dimensions of neighborhood privilege and disadvantage separately (ICE-income, ICE-r

27 ortant role in maintaining testicular immune privilege and display reduced proinflammatory capacity c

28 ssed their role in developing RS cell immune privilege and survival.

29 n transplants because of the inherent immune privilege and tolerogenic mechanisms associated with the

30 We took the advantages of immune privilege and transparent nature of developing zebrafish

31 There were 28,808 privileged and 19,996 full-time equivalent intensivists

32 novel approach to estimating the numbers of privileged and full-time equivalent intensivists in acut

33 , the median (25-75th percentile) numbers of privileged and full-time equivalent intensivists were 11

34 This organization that privileges animals and their features over objects might

35 5S) conformation of scaffold 2 resulted in a privileged architecture with increased affinity and sele

36 oducts entail biologically pre-validated and privileged architectures for TRP recognition.

37 us system (CNS) and disruption of its immune privilege are major contributors to the pathogenesis of

38 aptations of the immune system coined immune privilege are required to confer protection from autoatt

39 g men with lung cancer residing in currently privileged areas that had been redlined (risk ratio = 1.

40 avors those residing in or able to travel to privileged areas, to the detriment of the patients dying

41 wn of stem cell lineage confinement-granting privileges associated with both fates-is not only hallma

42 starkly with whites and minorities from more privileged backgrounds, for whom college completion is a

43 y provides efficient and rapid access to the privileged benzimidazol-2-one scaffold.

44 This ligand's privileged bidentate coordination mode and thioether mot

45 ction of fragments that bind proteins with a privileged binding mode, in the absence of any structura

46 applied to 2-pyrones, which are delicate and privileged biological motifs.

47 atalysts are positively charged analogues of privileged bis(3,5-trifluoromethyl)phenyl substituted th

48 nt via activation of both systemic and local privileged brain tumor immune response.

49 enies reveal that C. intestinalis occupies a privileged branch in the tree of life: it is our nearest

50 he alpha-methylene C-H bonds of these highly privileged building blocks is of great importance, espec

51 Saturated aza-heterocycles are highly privileged building blocks that are commonly encountered

52 ed directly to the liver do not enjoy immune privilege but rather require immunosuppression to preven

53 psychological and brain development is not a privilege, but a fundamental right that requires special

54 s suggest that TM maintain testicular immune privilege by inhibiting NF-kappaB signaling through impa

55 of the approaching maltol-derived ylides are privileged by higher barriers for dimerization and thus

56 These findings preclude privileged C-tactile-lamina I-spinothalamic projections

57 Arenes and heteroarenes are privileged candidates for (18)F-incorporation as they ar

58 However, the mechanistic hallmarks of privileged catalysts are not easily enumerated or readil

59 Privileged cells display an ultrafast cell cycle of appr

60 atal porcine Sertoli cells (NPSC) are immune privileged cells showing innate phagocytic and antibacte

61 se natural biopolymers comprise functionally privileged chemical scaffolds for folding or the evoluti

62 reasingly important and should be considered privileged chemical structures.

63 Correction for 'Privileged chiral N-heterocyclic carbene ligands for asy

64 s disease (toxocariasis) mainly in the under-privileged communities in developed and developing count

65 on that microbes can access and replicate in privileged compartments within host cells has led to man

66 In this work, the energetically privileged conformation of a disaccharide (lactose as te

67 action driven by inner conviction; hierarchy privileges conformity, order, and security; and individu

68 Med1 by GST pulldown experiments indicating privileged contacts between these two subunits of the ME

69 roach for the synthesis of pharmacologically privileged disubstituted naphthalene-1,4-diols and napht

70 together, our findings indicate E6AP to be a privileged E3 for the proteasome, with a dedicated, high

71 lthy worker survivor effect, the desperation/privilege effect (differential workforce reentry after p

72 hat the healthy hire effect, the desperation/privilege effect, the reproductively unhealthy worker ef

73 Here, we identify privileged end-adjacent regions (EARs) spanning roughly

74 atent pathogens and persistence in an immune-privileged enteric niche.

75 Invasion of immunologically privileged erythrocytes provides a relatively protective

76 nt of TP53 mutant MDS and sAML has an immune-privileged, evasive phenotype that may be a primary driv

77 cularly stable and influential, representing privileged experiences that shape enduring behaviors.

78 We suggest that people privilege explanations relying on inherent rather than c

79 The ability of ADCC to protect the immune-privileged eye, however, may differ from skin or vaginal

80 e antigens are sequestered within the immune-privileged eye.

81 We demonstrate that although no structurally privileged folding level exists, TADs emerge as a functi

82 ilar properties, or rather TADs constitute a privileged folding scale with maximal impact on the orga

83 However, GCs are considered to be immune privileged for antiviral CD8 T cells.

84 ers should be cautious about approving laser privileges for optometrists practicing in other states u

85 itively establishing the V exon location as "privileged" for SHM.

86 As yet, there are a few examples of privileged fuel chemistries that can be broadly applied

87 it strategies to 1) exploit the epithelia as privileged growth niches and 2) chronically target cellu

88 rt sequence, of a constrained mimetic of the privileged H-bonded conformation of (-)-lobeline.

89 Hers is an extraordinary tale of privilege, hardship, discrimination, shocking perseveran

90 rylthio indole was smoothly diversified with privileged heterocycle triazole to provide 2-(1 H-triazo

91 Triazoles are privileged heterocycles for a variety of applications.

92 Indoles are privileged heterocycles found in many biologically activ

93 and limits inflammation, designated "immune privilege." However, there is not an absolute lack of an

94 recently the brain was thought to be "immune privileged." However, it is now known that the immune sy

95 system (CNS) is classically viewed as immune-privileged; however, recent advances highlight interacti

96 signals regulate the disruption of avascular privilege in photoreceptors are unknown.

97 proposing a revised interpretation of immune privilege in the brain, which takes beneficial neuro-imm

98 ht that the theta-burst rhythm is relatively privileged in its ability to influence hippocampal memor

99 The liver appears to be privileged in terms of immune tolerance, with a low inci

100 ons predict that the Diels-Alder reaction is privileged in the case of ethyl nitrosoacrylate and poin

101 consistently across disciplines for granting privileges in EBTs that reflect the necessary knowledge

102 hat mechanisms associated with ocular immune privilege, in combination with paucity of age-related an

103 tumors may exhibit the phenomenon of immune privilege, in which immunogenic tissue is protected from

104 ication has been based on SVM learning using privileged information and SVM with uncertain classes.

105 At the hospital level, hospitals with privileged intensivists had significantly more hospital

106 spitals without intensivists, hospitals with privileged intensivists were primarily located in metrop

107 Together, our work uncovers a privileged interaction between defined members of the mi

108 ntry into nonphagocytic cells, creation of a privileged intracellular niche, and subversion of potent

109 maintaining physiologic hair follicle immune privilege (IP); the extent to which these functions are

110 Corneal immune privilege is integral in maintaining the clear avascular

111 rectly through reduced interference from the privileged item.

112 previously difficult-to-access precursors of privileged ligands like BINOL, BINAM, QUINAP and many ot

113 broadly, these results challenge the assumed privileged link between bistable stimuli and visual awar

114 limited stimulus sampling, and there was no privileged link between boundary extension and scene con

115 uncovered early-emerging flexibility and no privileged link between kinds and essences.

116 This privileged linker can enhance CMP-based biomaterials and

117 innervate the surfaces of mammalian bone, a privileged location for the regulation of biomechanical

118 se of infection because the bacteria hide in privileged locations.

119 s ago, as societal wealth increased to allow privileging long-term goals over immediate needs.

120 rther discuss how mimicking the bulge immune privilege may be an effective melanoma prevention strate

121 r findings on molecular mechanisms of immune privilege may be responsible for the failure of immune-t

122 od and adulthood experiences of neighborhood privilege, measured by the Index of Concentration at the

123 lloimmunity, including immune and angiogenic privilege, mechanisms of allosensitization, cellular and

124 th an embedded cinnamic acid derivative, two privileged medicinal chemistry scaffolds.

125 n tick saliva that create an immunologically privileged micro-environment in the host's skin.

126 ules to immune cells, resulting in an immune privileged microenvironment.

127 Selective AII connections ensure that a privileged minority of RGC types receives direct input f

128 Split inteins are privileged molecular scaffolds for the chemical modifica

129 ntroduce DTTs and related architectures as a privileged motif to engineer chalcogen bonds into functi

130 Bicyclic chiral scaffolds are privileged motifs in medicinal chemistry.

131 Vinyl sulfones are privileged motifs known for their biological activity an

132 rstanding of the catalyst structure in these privileged multifunctional frameworks and identify new d

133 udies established, among other features, the privileged nature of a properly positioned nitro moiety

134 system by the expression of immunologically privileged neuronal-site NE genes, and NE genes could po

135 ctions as a component of the immunologically privileged niche surrounding HRS cells and raise the pos

136 played a key role in formation of the immune-privileged niche, and predicted poor prognosis in human

137 tter candidate for the source of belief in a privileged now.

138 e cognitive underpinnings of the belief in a privileged "now moment" because they do not explicitly a

139 g graduate students, we had the pleasure and privilege of being in Joan Steitz's laboratory at a pivo

140 le the Society has grown with the historical privilege of close connections to institutions through a

141 Strategies to reverse the immune privilege of PDAC, which is regulated by extratumoral ma

142 l of Clinical Investigation and have had the privilege of publishing scientific knowledge that will b

143 lenged the traditional view about the immune privilege of the brain, but the precise roles of immune

144 The concept of immune privilege of the central nervous system (CNS) has domina

145 We examine the notion of immune privilege of the CNS in light of both earlier findings a

146 tions of a revised perspective on the immune privilege of the CNS on the etiology and pathology of di

147 mphasizes the fact that understanding immune privilege of the CNS requires intimate knowledge of its

148 rovoked dismissal of the existence of immune privilege of the CNS.

149 on (Ar) at room temperature has remained the privilege of the most reactive electrophiles, all of whi

150 he CNS remains speculative, given the immune privilege of this organ.

151 f early childhood and adulthood neighborhood privilege on preterm delivery and related disparities.

152 health statistics, and eligibility rules for privileges or benefits.

153 s may include loss of tolerance in an immune-privileged organ and subsequent development of T-cell-dr

154 he brain, previously thought of as an immune-privileged organ, is now known to communicate extensivel

155 As an immune-privileged organ, the placenta can tolerate the introduc

156 ver is both an immunologically complex and a privileged organ.

157 uring maturation in the thymus, a complement-privileged organ.

158 macrophages or if ranavirus exploits immune privileged organs, such as the brain, in order to establ

159 One item might be privileged over others, making it more accessible and th

160 from this review that there is no single or privileged perspective to study interruptions.

161 numerous available reference genomes, offer privileged perspectives to further examine these fundame

162 substituted anilines and quinazolines, both privileged pharmacological structures, are cumbersome, h

163 al conditions, suggesting that it might be a privileged pharmacological target.

164 4-(Pyrimidin-4-yl)morpholines are privileged pharmacophores for PI3K and PIKKs inhibition

165 e in medicinal chemistry and have emerged as privileged pharmacophores in proteasome inhibitors.

166 lytic system for the synthesis of the highly privileged phenethylamine pharmacophore is reported.

167 omic rearrangement events underlie an immune privilege phenotype in a subset of B-cell lymphomas.

168 an employment relationship with any of their privileged physicians.

169 an employment relationship with any of their privileged physicians.

170 s as to its value, and none should receive a privileged place in economic analysis of climate policy.

171 placental viral infections within the immune-privileged placenta.

172 lticomponent method for the synthesis of the privileged polyketide 1,3-dienyl-6-oxy motif.

173 We have identified the privileged position in the core scaffold of the imidazo[

174 al-based nanocatalysis, palladium occupies a privileged position mainly due to its remarkable versati

175 iew, we explore how calcium ended up in this privileged position.

176 select behaviorally relevant information for privileged processing.

177 suppress basal protein synthesis, preserving privileged production of defense proteins of the innate

178 s access to diverse materials featuring both privileged (PU) and unexplored (PA) microstructures.

179 ey's angular size and speed co-vary within a privileged range.

180 The robust method leverages the privileged reactivity of alcohols bearing electronegativ

181 RC1, the gatekeeper of anabolism, occupies a privileged regulatory position.

182 ous pathogens, yet the mechanisms enabling a privileged relationship with commensals remain largely u

183 tations based on reward values, suggesting a privileged replay of information yielding positive outco

184 network that creates and maintains a set of privileged replicator structures through auto- and cross

185 siding in census tracts lacking such current privilege (risk ratio = 1.01, 95% confidence interval: 0

186 ments highlight the role of hydrides and the privileged role for two irons of the trigonal prism in t

187 ctive or passive turns in the dark implies a privileged role for vestibular cues during human angular

188 These data suggest a privileged role for vHPC-mPFC theta-frequency communicat

189 Thus, threonine sites play a privileged role in promoting timely arrestin binding and

190 Locally translated CaMKII has a privileged role in regulation of spontaneous release, wh

191 rain areas, but that the striatum may have a privileged role in timing because it has a more accurate

192 These results identify a privileged role of Treg cell-derived TGF-beta1 in regula

193 eleton is identified for the first time as a privileged scaffold for further cost-effective developme

194 Indazoles represent a privileged scaffold in medicinal chemistry.

195 arting materials, and short syntheses of the privileged scaffold indeno[1,2-c]isoquinolinone were ach

196 d solar cells and because the newly emerging privileged scaffold is embedded in an inspiring structur

197 ted that the 6-aminoquinolone chemotype is a privileged scaffold to obtain antibacterial and antivira

198 We used a privileged scaffold with proven cellular potency as well

199 ology for a rapid and modular access to this privileged scaffold.

200 As this field expands, the use of these privileged scaffolds has permitted the development of to

201 s to aryl-alpha-ketoamide amides, a class of privileged scaffolds in medicinal chemistry and importan

202 ran (THP)-fused bicyclic gamma-lactones, two privileged scaffolds often found in natural products.

203 In this review, we will detail those privileged scaffolds that have guided medicinal chemistr

204 However, the notion of macrocycles simply as privileged scaffolds that primarily project side-chain s

205 ucts, thereby offering rapid access to these privileged scaffolds with high chemo-, regio- and enanti

206 cteristics and high titers, novel analogs of privileged scaffolds, novel natural products, and new ac

207 doles, 2-aryl indoles have been described as privileged scaffolds.

208 level exists, TADs emerge as a functionally privileged scale defined by maximal boundary enrichment

209 tion via two separate dendrites, providing a privileged scenario for in vivo examination of dendritic

210 al licensure requirements, credentialing and privileging, scope of care, quality, and responsibility

211 broadly-tuned face detection mechanism which privileges sensitivity over selectivity.

212 er a new ability to both profile kinetically privileged sensors (KPSs) of RES at a systems level (G-R

213 Experts agreed that privileges should be granted based on video review of su

214 d organ with specialized functions, and is a privileged site for the generation of both peripherally

215 ction in the seminiferous tubules, an immune-privileged site in the testis protected by the blood-tes

216 ortant viral reservoir in an immunologically privileged site in vivo, whether immunological perturbat

217 relevant F1 sialic acid-binding pocket is a privileged site inaccessible to antibodies, that the F2

218 The lens has been considered to be an immune privileged site not susceptible to the immune processes

219 al view that the brain is an immunologically privileged site shielded behind the blood-brain barrier,

220 em has historically been viewed as an immune-privileged site, but recent data have shown that the men

221 As an immune-privileged site, the eye, and particularly the outer cor

222 y DLBCL samples, including 44 primary immune-privileged site-associated DLBCL (IP-DLBCL) samples orig

223 nging because the eye is a relatively immune-privileged site.

224 fuse large B-cell lymphoma arising in immune-privileged sites (eg, the central nervous system) shows

225 hypothesis that B cell follicles are immune privileged sites and suggest that strategies to augment

226 arrying infectious virus particles to immune privileged sites and/or to sites protected by physical b

227 ells using prime-boost vaccines by targeting privileged sites for Ag presentation.

228 red for dissemination of the virus to immune privileged sites has not been definitively shown.

229 he expression of proteins at immunologically privileged sites such as neurons on endothelial cells ma

230 rus (ZIKV) can establish infection in immune privileged sites such as the testes, eye, and placenta.

231 BOV disseminates into and persists in immune-privileged sites was impossible due to the absence of a

232 tolerance in the gut and the eye, two immune-privileged sites where immunosuppressive responses are c

233 ctions in humans, mainly localized in immune privileged sites, such as the brain and the eye.

234 Because synovial joints include immune privileged sites, these findings are significant for fut

235 ion, revealing the need to target these drug-privileged sites.

236 an persist in survivors for months in immune-privileged sites; however, viral relapse causing life-th

237 nature of reprogramming can be overcome in a privileged somatic cell state and suggest that cell-cycl

238 We identified a privileged somatic cell state, from which acquisition of

239 sequentially so that the last item was in a privileged state by virtue of recency.

240 animal development gained an epigenetically privileged state in germ cells, manifested in amniotes b

241 cue" to bring one of the two targets into a privileged state.

242 we show that Del-1 contributes to the immune privilege status of the CNS.

243 Our findings demonstrate both the privileged status of germline genome integrity and speci

244 As a result, it has become recognized as a privileged structural feature for targeting a wide range

245 The bicyclo[3.3.1]nonane architecture is a privileged structural motif found in over 1000 natural p

246 1,4-Disubstituted aromatic piperazines are privileged structural motifs recognized by aminergic G p

247 G protein-coupled receptors (GPCRs) are privileged structural scaffolds in biology that have the

248 s is likely to permit the identification of "privileged" structural scaffolds, providing frameworks s

249 Chromone is recognized as a privileged structure and a useful template for the desig

250 esign of allosteric modulators, appears as a privileged structure for the pharmacophore-based computa

251 from the 1,4-benzodiazepin-2-one nucleus, a privileged structure in medicinal chemistry, we have syn

252 steric antagonists based on the 2-arylindole privileged structure scaffold (e.g., 1-3).

253 Substitution on the phenylpiperazine privileged structures (2-methoxy vs 2,3-dichloro) influe

254 gy on examples of pharmacologically relevant privileged structures 5,6-dihydropyridin-2(1H)-ones and

255 ely related HIV-1 protease were evaluated as privileged structures against HTLV-1 protease (HTLV-1 PR

256 ation of a benzoxazinone M1 scaffold with D2 privileged structures derived from putative and clinical

257 k validates chromone-based acylhydrazones as privileged structures for antagonizing STAT SH2 domains,

258 ts of efficacy, affinity, and bias for three privileged structures for the D2R, exploring changes to

259 The synthetic utility of the privileged structures formed from this one-pot process w

260 The use of privileged structures in drug discovery has proven to be

261 The isoxazolidine ring represents one of the privileged structures in medicinal chemistry, and there

262 g our studies on flavonoid-like scaffolds as privileged structures in medicinal chemistry, in this pa

263 2-dihydro-3H-indazol-3-ones, which are known privileged structures possessing remarkable diverse phar

264 Privileged structures such as 2-arylindoles are recurren

265 hydroisoquinoline head group with other D2R "privileged structures" generated orthosteric antagonists

266 he tetrahydroisoquinoline (THIQ) moiety is a privileged substructure of many bioactive natural produc

267 ture-guided hybridization approach using two privileged substructures gave instant access to a new se

268 Despite the potential applications of these privileged substructures in drug discovery, efficient, a

269 s for the synthesis of diverse collection of privileged substructures needed for a drug design and di

270 though the retina is often considered immune-privileged, suppression of host immune-mediated cell rej

271 catalyzed cascade reaction of four versatile privileged synthons is described.

272 stituted 4-quinolinones, an underrepresented privileged template.

273 ragment-molecules, most of which contain the privileged tetrahydropyran (THP) scaffold.

274 ietal systems of self-serving domination and privilege that structure the embodiment of health inequi

275 We are both pleased and privileged that each of us has practiced our profession

276 ly significant"; 2) nullism, the tendency to privilege the hypothesis of no difference or no effect w

277 Rather than privileging the self comprising primarily individual qua

278 hat slow oscillatory up-states may represent privileged time windows for memory reactivation, while t

279 region of the hair follicle (HF), an immune-privileged tissue niche with impaired tumor immunosurvei

280 tissue reservoir rather than immunologically privileged tissues (i.e., testes).

281 nnate-like B-1 B cells, which provide immune privilege to malignant cell foci.

282 I have had the privilege to work in institutions in four different coun

283 It has been a true privilege to work with the cell biology community; I tha

284 also covering many wonderful people I had a privilege to work with, are summarized below.

285 in some nausea responses and is anatomically privileged to detect blood-borne signals.

286 We are also privileged to get support from Arthur Wilde (University

287 few states where optometrists have surgical privileges to perform laser trabeculoplasty (LTP).

288 rists in other states are lobbying to obtain privileges to perform LTP and other laser procedures.

289 clinician must achieve before being granted privileges to perform these procedures.

290 beta3 integrin subtype, thereby representing privileged tools for integrin-based personalized medicin

291 integrated stress response (ISR) that show "privileged" translation despite inhibited eukaryotic ini

292 provides cheminformatics insights into this privileged, underexplored structural class of compounds

293 sist nearer the active zone and exhibit more privileged use in the next RRP.

294 CR1(hi) patrolling monocytes serve as immune-privileged vehicles to transport MCMV via the bloodstrea

295 The results are in line with privileged visual processing of hands as highly salient

296 epithelia in angiogenic and lymphangiogenic privilege, we designed five injury models involving debr

297 tracts with present-day economic and racial privilege, whereas the best historical HOLC grade was no

298 pithelium is important for (lymph)angiogenic privilege, whereas the limbus does not act as a physical

299 ogenous genes in heterochromatic contexts as privileged while foreign DNA can be suppressed with no r

300 Among these, tetracyclic terpenoids are privileged, with >100 being FDA-approved drugs.