ライフサイエンスコーパス: pro-opiomelanocortin

1 -Y and pro-opiomelanocortin signals favoring pro-opiomelanocortin.

2 d epidermal melanocytes, as well as mRNA for pro-opiomelanocortin.

3 ary hormones lutropin (LH), thyrotropin, and pro-opiomelanocortin.

4 , the intracellular routing and secretion of pro-opiomelanocortin/adrenocorticotropin and growth horm

5 ized by the expression of specific peptides (pro-opiomelanocortins, agouti-related protein, and neuro

6 terns, leptin sensitivity, and expression of pro-opiomelanocortin/agouti-related peptide/neuropeptide

7 map changes in the mRNA expression of MC3R, pro-opiomelanocortin and agouti-related peptide followin

8 cle, and adipose tissue as well as increased pro-opiomelanocortin and decreased agouti-related peptid

9 Both pro-opiomelanocortin and growth hormone levels were elev

10 he intracellular misrouting and secretion of pro-opiomelanocortin and growth hormone via the constitu

11 alter mRNA levels of agouti-related peptide, pro-opiomelanocortin and MC3R.

12 iscovered several proteolytic proteoforms of pro-opiomelanocortin and prodynorphin with significantly

13 macrophages/monocytes were found to express pro-opiomelanocortin and to now constitute the majority

14 nephrine and in hypothalamic neuropeptide Y, pro-opiomelanocortin, and gamma-aminobutyric acid neuron

15 agonist 6beta-naltrexol; (2) pro-enkephalin, pro-opiomelanocortin, and pro-dynorphin KO mice showed r

16 ) was found to induce Fos expression in both pro-opiomelanocortin- and neuropeptide Y-expressing neur

17 products together with endogenous products, pro-opiomelanocortin- and PAM-derived products encoded b

18 Pro-opiomelanocortin anterior pituitary cells express si

19 Pro-opiomelanocortin (ARC(POMC)) neurons are viewed as t

20 anocyte stimulating hormone are derived from pro-opiomelanocortin as is beta-endorphin.

21 n, including corticotropin releasing factor, pro-opiomelanocortin B, and glucose transporter type 2 i

22 N- and O-linked oligosaccharides on pro-opiomelanocortin both bear the unique terminal seque

23 Glucose-sensitive mucosal pro-opiomelanocortin cells provide a local source of a-M

24 the arcuate nucleus were predominantly from pro-opiomelanocortin cells, with a notable lack of proje

25 pressed on agouti-related peptide (AgRP) and pro-opiomelanocortin-expressing (POMC) neurons; however,

26 throughout the central nervous system and on pro-opiomelanocortin-expressing cells in the hypothalamu

27 for ghrelin-triggered synaptic plasticity of pro-opiomelanocortin-expressing neurons, and for ghrelin

28 ptide cleaved from the precursor pro-hormone pro-opiomelanocortin, from which other peptides such as

29 H by induction of cAMP with up-regulation of pro-opiomelanocortin gene expression and subsequent prod

30 We analyzed DNA methylation of the POMC (pro-opiomelanocortin) gene, which is pivotal for satiety

31 ARC glucose-excited neurons did not show pro-opiomelanocortin immunoreactivity.

32 Here, we identify dysregulation of the pro-opiomelanocortin-melanocortin 1 receptor (POMC-MC1R)

33 d amounts of both leptin and arcuate nucleus pro-opiomelanocortin messenger RNA.

34 d in 68.1% of arcuate neurons that expressed pro-opiomelanocortin mRNA but was not significantly coex

35 leus (pPVN) and increased anterior pituitary pro-opiomelanocortin mRNA expression 4 h after IL-1beta

36 ral nucleus of the solitary tract, a site of pro-opiomelanocortin mRNA expression.

37 Pro-opiomelanocortin mRNA was also decreased after dexam

38 hown to bind to an amino-terminal peptide of pro-opiomelanocortin (N-POMC) at pH 5.5 and hypothesized

39 These agouti-related peptide and pro-opiomelanocortin neurons act via brain-derived neuro

40 e significant disparities in the identity of pro-opiomelanocortin neurons and in the expression level

41 ce, deletion of the Neuropilin-2 receptor in Pro-opiomelanocortin neurons disrupted their projections

42 t stress in mice results in hyperactivity of pro-opiomelanocortin neurons in the arcuate nucleus of t

43 are mediated via agouti-related peptide and pro-opiomelanocortin neurons in the hypothalamic arcuate

44 urthermore, genetic deletion of autophagy in pro-opiomelanocortin neurons of ob/ob mice worsens their

45 ses revealed that Sirt1 mRNA is expressed in pro-opiomelanocortin neurons that are critical for norma

46 , by stimulating beta-endorphin release from pro-opiomelanocortin neurons that innervate the POA/AH.

47 ocyte-derived hormone leptin, stimulation of pro-opiomelanocortin neurons, and subsequent activation

48 etion through the sympathetic system and via pro-opiomelanocortin neurons, which could serve as the c

49 Leptin activates pro-opiomelanocortin neurons, which produce melanocortin

50 P-1 receptors with neuropeptide tyrosine and pro-opiomelanocortin neurons.

51 s of neuropeptide Y, agouti-related peptide, pro-opiomelanocortin, or cocaine- and amphetamine-relate

52 stream regulatory elements to assess whether pro-opiomelanocortin peptide (POMC), and its opioid clea

53 anocytes deprived of any exogenous supply of pro-opiomelanocortin peptides.

54 se, the melanocortin system, which comprises pro-opiomelanocortin (POMC) and agouti-related peptide (

55 e the effects of STZ-diabetes and fasting on pro-opiomelanocortin (POMC) and agouti-related peptide (

56 Pro-opiomelanocortin (POMC) and agouti-related protein (

57 nin-concentrating hormone] and anorexigenic [pro-opiomelanocortin (POMC) and cocaine-amphetamine-rela

58 mRNA levels of pro-dynorphin (proDYN), pro-opiomelanocortin (POMC) and pro-enkephalin (proENK)

59 rocessing of two neuroendocrine prohormones, pro-opiomelanocortin (POMC) and pro-orphanin FQ (pOFQ)/n

60 ulate appetite, namely neuropeptide Y (NPY), pro-opiomelanocortin (POMC) and the leptin receptor isof

61 e we show that suppression of ROS diminishes pro-opiomelanocortin (POMC) cell activation and promotes

62 rtisolism and elevated plasma proinsulin and pro-opiomelanocortin (POMC) concentrations but a very lo

63 protein (AgRP) mRNA expression increased and pro-opiomelanocortin (POMC) decreased in response to fas

64 functional loss of both alleles of the human pro-opiomelanocortin (POMC) gene leads to a very rare sy

65 Posttranslational modification of the pro-opiomelanocortin (POMC) gene transcript results in t

66 he two pituitary cell types that express the pro-opiomelanocortin (POMC) gene, the anterior lobe cort

67 Since alpha-MSH is coded for by the pro-opiomelanocortin (POMC) gene, we examined if POMC ge

68 ), corticotropin-releasing hormone (CRH) and pro-opiomelanocortin (POMC) in the context of the limbic

69 uced CD68 expression and fewer contacts with pro-opiomelanocortin (POMC) neuron processes.

70 and mice with 5-HT2CRs re-expression only in pro-opiomelanocortin (POMC) neurons (2C/POMC mice).

71 Hypothalamic pro-opiomelanocortin (POMC) neurons are principal regula

72 rotonin 2C receptors (Htr2c) specifically in pro-opiomelanocortin (POMC) neurons had normal body weig

73 Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-t

74 The arcuate pro-opiomelanocortin (POMC) neurons in particular have b

75 gnaling in agouti-related protein (AgRP) and pro-opiomelanocortin (POMC) neurons in regulating hepati

76 Pro-opiomelanocortin (POMC) neurons in the arcuate nucle

77 also find that astrocyte stimulation excites pro-opiomelanocortin (POMC) neurons in the arcuate nucle

78 In the hypothalamic arcuate nucleus (ARC), pro-opiomelanocortin (POMC) neurons inhibit feeding and

79 irst-order agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) neurons located in the hypot

80 tonin 2C receptors (5-HT(2C)Rs) expressed by pro-opiomelanocortin (POMC) neurons of hypothalamic arcu

81 Hypothalamic pro-opiomelanocortin (POMC) neurons promote satiety.

82 ivation of Nscl-2 in GnRH neurons but not in pro-opiomelanocortin (POMC) neurons reduced POMC neurons

83 enetic stimulation of ARC TH cells inhibited pro-opiomelanocortin (POMC) neurons through synaptic mec

84 disrupted glucose sensing in glucose-excited pro-opiomelanocortin (POMC) neurons via transgenic expre

85 In addition, we found that pro-opiomelanocortin (POMC) neurons were crucial for the

86 n (AGRP) neurons and activating anorexigenic pro-opiomelanocortin (POMC) neurons(2).

87 mulation, likely including satiety-promoting pro-opiomelanocortin (POMC) neurons, demonstrated opposi

88 vation of hypothalamic arcuate nucleus (ARC) pro-opiomelanocortin (POMC) neurons, which are also disi

89 ed in the opposite direction in anorexigenic pro-opiomelanocortin (POMC) neurons.

90 asing the anorexigenic tone due to activated pro-opiomelanocortin (POMC) neurons.

91 etylcholine receptors leads to activation of pro-opiomelanocortin (POMC) neurons.

92 lized by re-expression of 5-HT(2C)Rs only in pro-opiomelanocortin (POMC) neurons.

93 ed in mice with 5-HT(2C)Rs expressed only in pro-opiomelanocortin (POMC) neurons.

94 PY nerve terminals, thus activating adjacent pro-opiomelanocortin (POMC) neurons.

95 on with decreased number of appetite-curbing pro-opiomelanocortin (POMC) neurons; whether the reducti

96 outi-related peptide (AgRP) and anorexigenic pro-opiomelanocortin (POMC) neuropeptides.

97 RNA levels of ProDynorphin (proDYN), but not pro-opiomelanocortin (POMC) nor proEnkephalin (proENK) w

98 Mice lacking ROCK1 in either pro-opiomelanocortin (POMC) or agouti-related protein ne

99 ol include hypothalamic neurons that express pro-opiomelanocortin (POMC) or neuropeptide-Y (NPY) and

100 ally, CerS6 deficiency in neurons expressing pro-opiomelanocortin (POMC) or steroidogenic factor 1 (S

101 pression of agouti-related peptide (AGRP) or pro-opiomelanocortin (POMC) positively and negatively in

102 uropeptide Y and increases expression of the pro-opiomelanocortin (POMC) precursor of alphaMSH.

103 Melanocortins are peptides, cleaved from the pro-opiomelanocortin (POMC) precursor, that act in the b

104 eight, food intake, glucose homeostasis, and pro-opiomelanocortin (POMC) projections.

105 AtT20 pituitary cells transfected with a rat pro-opiomelanocortin (POMC) promoter (-706/+64) linked t

106 mic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and bod

107 , multiple agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) subtypes, and an orexigenic

108 sorting receptor that directs the prohormone pro-opiomelanocortin (POMC) to the regulated secretory p

109 ypothalamic circuits, resulting in increased pro-opiomelanocortin (POMC) tone, followed by decreased

110 Thus, mRNAs encoding NPY and pro-opiomelanocortin (POMC) were colocalized in the arcu

111 membranes containing [(35)S]sulfate labeled pro-opiomelanocortin (POMC)(5) in the trans-Golgi, we ca

112 Pro-opiomelanocortin (POMC), ACTH, and cortisol were mea

113 CSF and plasma were analyzed for pro-opiomelanocortin (POMC), adrenocorticotropin hormone

114 oexpress the melanocortin precursor molecule pro-opiomelanocortin (POMC), and administration of insul

115 ular peptides from secretogranin-1, ProSAAS, pro-opiomelanocortin (POMC), and others.

116 rotein 130 (gp 130), leptin receptor (OB-R), pro-opiomelanocortin (POMC), neuropeptide Y (NPY), gluco

117 om peptides derived from the ACTH precursor, pro-opiomelanocortin (POMC), to maintain its tonic state

118 We report on a common canine mutation in pro-opiomelanocortin (POMC), which prevents production o

119 Pro-opiomelanocortin (POMC)- and agouti-related peptide

120 Because the pro-opiomelanocortin (POMC)-derived melanocortin system

121 Pro-opiomelanocortin (POMC)-derived peptides (the melano

122 The pro-opiomelanocortin (POMC)-derived peptides, alpha-mela

123 lamus (ARH) satiety signaling (anorexigenic) pro-opiomelanocortin (POMC)-expressing and hunger signal

124 We show that FoxO1 ablation in pro-opiomelanocortin (Pomc)-expressing neurons in mice (

125 Pro-opiomelanocortin (POMC)-expressing neurons in the ar

126 Satiety-signaling, pro-opiomelanocortin (POMC)-expressing neurons in the ar

127 ssing neurons but induces no net response in pro-opiomelanocortin (POMC)-expressing neurons.

128 ng glucokinase regulatory protein (GCKR) and pro-opiomelanocortin (POMC).

129 nthesis and packaging of a sulfated hormone, pro-opiomelanocortin (POMC).

130 bioactive peptides are cleavage products of pro-opiomelanocortin (POMC).

131 B) and STAT3, and dampened the production of pro-opiomelanocortin (POMC, the precursor of a-melanocyt

132 and amphetamine-regulated transcript, CART; pro-opiomelanocortin, pomc1a) neurons in the brain.

133 s, including neuropeptides deriving from the pro-opiomelanocortin precursor protein and localized a s

134 In order to follow possible pro-opiomelanocortin processing in the melanosome, human

135 trated the presence of the entire system for pro-opiomelanocortin processing in the melanosome.

136 The pro-opiomelanocortin product alpha-melanocyte stimulatin

137 omain also prevented stimulated secretion of pro-opiomelanocortin products in AtT-20 cells.

138 ws identification of 14 of these peptides as pro-opiomelanocortin prohormone-derived molecules.

139 ent protein (DsRed) under the control of the pro-opiomelanocortin promoter and distal upstream regula

140 transgenic mice in which 770-bp fragment of pro-opiomelanocortin promoter directs expression of the

141 recombinant adeno-associated virus encoding pro-opiomelanocortin (rAAV-POMC) or control vector was d

142 an autocrine intramelanosomal production of pro- opiomelanocortin-related peptides and an autocrine

143 these organelles themselves actually produce pro-opiomelanocortin-related peptides in their acidic en

144 t of an imbalance between neuropeptide-Y and pro-opiomelanocortin signals favoring pro-opiomelanocort

145 Neutrophils expressed pro-opiomelanocortin, the precursor of beta-endorphin (a

146 e PC chimeras efficiently cleaved endogenous pro-opiomelanocortin to the correct bioactive peptides.

147 receptor for targeting prohormones, such as pro-opiomelanocortin, to the regulated secretory pathway

148 In Cpefat mice, pro-opiomelanocortin was accumulated 24-fold above norma

149 Furthermore, pro-opiomelanocortin was secreted constitutively at high

150 mouse lacking CPE, the pituitary prohormone, pro-opiomelanocortin, was missorted to the constitutive

151 Double-label studies indicated that VGF and pro-opiomelanocortin were coexpressed in lateral arcuate