ライフサイエンスコーパス: probe

1 nd an LED driver for an external optogenetic probe.

2 an cell lines with a designer disulfide FRET probe.

3 etic resonance relaxometry and a fiber-optic probe.

4 ntration reported by using peptide-based TNT probe.

5 )Fe(CN)(6) as the encapsulated aqueous redox probe.

6 e for TTR-binding with a fluorescent FITC-T4 probe.

7 the chemical environment on the nuclei being probed.

8 ch are the brightest genetically encoded NIR probes.

9 or accurate prediction by common theoretical probes.

10 Some are fluorescent acting as turn-on probes.

11 ing peptide nucleic acid (PNA) hybridization probes.

12 ackground currents than those of traditional probes.

13 the release of bioactive agents and imaging probes.

14 ications using collections of cloned ORFs as probes.

15 d to transport it to the paper-based sensing probes.

16 subcellular organelles labeled with imaging probes.

17 oits aptamers as minimally invasive affinity probes.

18 g criteria that also evaluated bleeding upon probing.

19 A quenched protease-activated fluorescent probe 6qcNIR, which produces a signal only in the protea

20 ion-based biochemical circuit cascade, which probes a specific biomolecular input, transform the inpu

21 e generated an activity-based small-molecule probe (ABP) to track target engagement in vivo.

22 ties together with the opportunity to design probes against any sequenced genome.

23 the product itself (i.e. CO) as the local pH probe allows us to investigate CO(2) RR without the inte

24 -toxic, water-compatible ruthenium(II) vinyl probes allows the rapid, selective and sensitive detecti

25 Due to the amplification of probes, amplicons can be visualized with standard epiflu

26 The electroosmotic perfusion-microdialysis probe and associated method were used to determine the e

27 onal techniques use cell contact or invasive probes and as a result are low throughput, labor intensi

28 nd widespread applications as activity-based probes and as irreversibly binding drugs.

29 of sorter and parameters for a wide range of probes and brain regions.

30 oited gramicidin channels as molecular force probes and developed in silico and in vitro assays to me

31 ectrophilic warheads for chemical biological probes and drug molecules is demonstrated through site-s

32 hnology, synthesized multiplexed primers and probes and formulated a master mix composed of enzymes a

33 amined ROS accumulation using ROS-responsive probes and found reduced fluorescence of a superoxide-se

34 of the cyclophellitol-derived activity-based probes and inhibitors presented here make them a valuabl

35 ieved by the use of hairpin surface-tethered probes and the hybridization chain reaction was used to

36 Gingival status (bleeding on probing) and oral hygiene effectiveness (dental calculus

37 excitable optogenetic tools and fluorescent probes, and decreased scattering and absorption in mamma

38 and disadvantages associated with different probe architectures and describe the advances enabled by

39 These probes are often designed to target specific enzymes ass

40 Probing assays demonstrated that magnesium oxide alone o

41 The pH was measured with the probe at a constant distance from the electrode (ca. 75

42 , 2.6 +/- 1.1 nN) for a negatively polarized probe at a hydrophilic OH-terminated gold surface.

43 These activatable zymography probes (AZP) detected dysregulated protease activity in

44 Our study probed baboons' capacity to learn two supra-regular gram

45 hole pairs have been challenging to directly probe because of their inherently fast timescales.

46 Probing between 7 and 9 months appears to be reasonable

47 tribution of cholesterol accessible to a D4H probe, between late endosomes and the PM.

48 ng depth (PD), attachment level, bleeding on probing (BOP), and interproximal plaque index (API) were

49 Bleeding on probing (BOP), plaque index, and probing depth (PD) were

50 dulating the zeta potential of the detection probe by conjugating negatively charged DNA oligonucleot

51 ng scanning electrochemical microcopy (SECM) probe by covalently immobilizing the glucose oxidase (GO

52 Cleavage of this probe by the secreted S. aureus enzyme micrococcal nucle

53 Specific chemical bonds were probed by FTIR spectroscopy.

54 The reactivity of our system was further probed by photolyzing benzene/pyridine solutions of 4a u

55 evelopment of new fluorescent coumarin-based probes by researchers in the field.

56 ce of substrates, as well as, attraction and probing by psyllids.

57 Here we probed CB-M1 interactions using cerebellar brain inhibit

58 ccupancy as readouts, which may be useful to probe cell-microenvironment interactions.

59 single-nucleotide mutations is critical for probing cell biology and for precise detection of diseas

60 The nanoMIP tagged with a redox probe, combines both recognition and reporting capabilit

61 ht an electron-microscopy-based approach for probing complex-shaped nanophotonic structures.

62 enges in assigning reactive positions in the probe compounds for the monodentate attack leading to an

63 State-of-the-art tools used to probe connectivity with cell-type-specific resolution ha

64 DNA-based probes constitute a versatile platform for making biolog

65 Probes containing a fluorophore with negative charge sho

66 nformational change of the surface signaling probe (containing an electrochemical tag), leading to th

67 ted isothermal amplification (LAMP), the CHB probe could detect Borrelia burgdorferi (B. burgdorferi)

68 rent Raman scattering microscopy was used to probe de novo intracellular lipid content.

69 The mean percentage of sites with probing depth >=5 mm was reduced over the course of the

70 ssing teeth, percentage of sites with pocket probing depth >=6 mm, and mean pocket probing depth) had

71 Bleeding on probing (BOP), plaque index, and probing depth (PD) were confirmed reliable discriminants

72 Probing depth (PD), attachment level, bleeding on probin

73 Probing depth (PD), CAL, plaque index (PI), and interpro

74 tly associated with both outcomes (increased probing depth and bone loss).

75 pocket probing depth >=6 mm, and mean pocket probing depth) had an area under the curve (AUC) of 0.69

76 as performed, including bleeding on probing, probing depth, and clinical attachment level.

77 graft was associated with with reduction of probing depth, soft tissue dehiscence and plaque index c

78 f marker sequences or finding candidates for probe design by identifying approximate k-mers that are

79 Eight cases were discordant due to probe design differences, with focal abnormalities detec

80 o serve as a platform for multimodal imaging probe development.

81 model to simulate the SARS-CoV-2 pandemic by probing different scenarios based on known coronavirus b

82 Although unsuitable as biological probes due to widespread reactivity, dienone compounds a

83 mental stroke and patients by ischemic blood probing during the hyperacute stage of vascular occlusio

84 form, we have synthesized 6 distinct padlock probes, each rendering a unique two-color fluorescence s

85 We next probed effects on human cardiomyocyte contractility.

86 ent probe in the TL and a second fluorescent probe elsewhere in RNAP or in DNA, we detect and charact

87 sensor comprises highly fluorescent sensing probes embedded in paper substrates, and microfluidic ch

88 rthermore, besides technical innovations and probes, emerging clinical indications are highlighted.

89 as paved the way to the construction of FISH probes entirely from synthetic oligonucleotides (oligos)

90 -deuterated histidine produces a vibrational-probe-equipped amino acid that can readily be incorporat

91 cryptic docking site revealed only when the probe experiences forces exceeding a defined mechanical

92 a femtosecond time-resolved X-ray pump/X-ray probe experiment on protein nanocrystals.

93 The multiple timescales observed in the pump-probe experiments were connected to local structural flu

94 When we probed flies with salient visual stimuli, we found that

95 redox probes, Formaldehyde oxidative latent probe (FOLP) and dihydroxy-formaldehyde oxidative latent

96 ter cloacae), revealing it to be a promising probe for detecting Pse across bacterial species.

97 inhibitors present an alternative biological probe for further determining the clinical utility and s

98 nic kidney disease (CKD), we tested the FOLP probe for its ability to monitor creatinine.

99 veloped a small molecule fluorescent turn-on probe for labeling sphingosine in living cells.

100 tinine, carnitine, and metformin, which is a probe for OCT1 and OCT2 and MATE1 and MATE2K (multidrug

101 nucleoprotein, double stranded RNA, and RNA probe for spike genes were evaluated for the ability to

102 ed informatics framework, which allows us to probe for the contribution of equilibrium fluctuations t

103 rimary kinetic isotope effect can serve as a probe for these mechanisms, as confirmed in virtually al

104 yptophan (1-L-[(18)F]FETrp) as a PET imaging probe for this common malignant pediatric brain tumor.

105 rise to an entirely new generation of useful probes for bioimaging and biosensing.

106 However, highly selective probes for individual SHs are scarce because probe synth

107 In addition, a series of tetrazine probes for monoacylglycerol lipase (MAGL) were synthesiz

108 ration of miRFPs should become versatile NIR probes for multiplexed imaging across spatial scales in

109 s proof-of principle study provides valuable probes for NTMT1/2 and highlights the opportunity to dev

110 or repurposing of highly potent molecules as probes for previously unreported targets.

111 n spectroscopy mapping and calibrated Kelvin probe force microscopy.

112 ratiometric electrochemical molecular redox probes, Formaldehyde oxidative latent probe (FOLP) and d

113 The first method is optimized for probe-free applications: Domains are directly distinguis

114 e-templated reaction (EOTR), whereby two PNA probes - functionalized with an aniline and a 1,4-catech

115 However, approaches that allow us to probe G4s in living cells without perturbing their foldi

116 Remarkable and unique is the double probe given by (1)H and (11)B NMR tracing the reciprocal

117 seness (dot versus line/drop) and time after probing (>=15 seconds versus <15 seconds after probing v

118 2,5-di(1-naphthyl)-terephthalaldehyde-based probe has been applied for chirality sensing of primary

119 hroism that uses electronic transitions as a probe has by far been the method of choice while Vibrati

120 The sensor probe has successfully recovered ALP between 108.84% and

121 and that selection of cell-type informative probes has similar effect.

122 and dihydroxy-formaldehyde oxidative latent probe (HFOLP), for the selective profiling of endogenous

123 e-symptomatic tissue from eye bank donors to probe how gene expression changes precede disease; and (

124 We probe how these motions depend on voltage and frequency

125 cal interactions with vesicle trafficking to probe how various processes might affect polarity site m

126 nd performance of an integrated microfluidic probe (iMFP) for nano-DESI MSI.

127 ic characterization, we demonstrate that the probe improves quality and conditions for regular and si

128 of ferrocenemethanol as an additional redox probe in the aqueous solution (at room temperature and w

129 accumulation of the conjugated fluorescence probe in the placenta with a total accumulation of 2.8%

130 energy transfer between a first fluorescent probe in the TL and a second fluorescent probe elsewhere

131 eic acid (so-called "acpcPNA") was used as a probe in this study because it offers higher specificity

132 By incorporating different hairpin probes in an alternating DNA copolymer, multiplex recogn

133 We evaluated the performance of the probes in mouse models of mammary tumours and of metasta

134 These events can be probed, in principle, by monosaccharides with bioorthogo

135 ystemic administration of an in vivo imaging probe incorporating S16 perfectly classified diseased an

136 JSR) and time-of-flight mass spectrometry to probe intermediates formed.

137 selection of methods and molecular tools for probing interorganellar membrane contact sites.

138 The selective insertion of the probe into a microtubule triggers remarkable fluorescenc

139 ensity (ACID) were utilized in this study to probe into the aromaticity-related parameters of the pro

140 ntities of NanO2-IR or by microinjecting the probe into the lumen of small or large intestine fragmen

141 The correlation of the scanning-probe IR images and the mechanical phase image enables a

142 In the presence of the target the probe is "silenced".

143 Probing is a safe and effective procedure.

144 efSeq, and an online tool to generate custom probe libraries.

145 a novel species-specific electrochemical DNA probe (locked nucleic acid, LNA) was synthesized and imp

146 tive manatees, and at minimum, penetrate and probe manatee epidermis with their mouthparts.

147 c islet microscopy we demonstrated that ODND probes may be used to distinguish between the islets wit

148 Compared to single probing measurements, COM seems (1) more accurate in cap

149 The Protein-Probe method is based on highly luminescent europium che

150 tion of the CHIKV genome, we used a chemical probing method to define the RNA secondary structures of

151 use a combination of atom-resolved scanning probe microscopy and density functional theory to reveal

152 Recent advances in scanning probe microscopy on surface enable not only direct obser

153 h an electric field gradient from a scanning probe microscopy tip.

154 uced side effects and provides an attractive probe molecule and lead compound.

155 l confinement with the molecular size of the probe molecule, the free volume element size probability

156 2) RR without the interference of additional probe molecules introduced to the system.

157 ue samples stained with a nanoparticle based probe, NanO2-IR.

158 elusive due to a lack of methods to directly probe nanoscopic membrane features.

159 We demonstrate visible pump soft X-ray probe near-edge X-ray absorption fine structure (NEXAFS)

160 that cost-effective, multi-region, and multi-probe Neuropixels recordings can be carried out with hig

161 We probed nicotinic cholinergic influences on acoustic resp

162 tiffness, provides an attractive non-contact probe of corneal elasticity.

163 in nitrogen-starved bacteria as a biological probe of E. coli cell function during nitrogen starvatio

164 bstrate, an inhibitor, and an activity-based probe of Granzyme A (GrA) that can be used to follow fun

165 rofiles lays the groundwork for non-invasive probes of bacterial metabolism and offers prospects for

166 Ru(III/II)P and TPA(+/0) make them excellent probes of outer-sphere reorganization energy, lambda(o),

167 cale but are at the same time also sensitive probes of the long-range interactions that control the g

168 of reactive systems has enabled microscopic probes of underlying interaction potentials and the alte

169 he mechanical phase image enables a combined probing of mechanical material properties together with

170 capacity of the device might facilitate the probing of the spatiotemporal neural codes underlying be

171 Optical probes operating in the second near-infrared window (NIR

172 or lead compounds into high-quality chemical probes or drug candidates is an ongoing challenge in bio

173 versatility and sensitivity of the electron probe, our method would allow capturing the electronic d

174 pendent quenching of phosphorescence, oxygen probe Oxyphor PtG4 and the radiotherapy-induced Cherenko

175 ncrease in accumulation compared to the free probe (p < .0001), and 2-4 fold accumulation compared to

176 ding of proteins to functionalized colloidal probe particles by monitoring the associated change in t

177 s can be interrogated by a single reflection probe placed on a fixed position over the chip and the r

178 throughput, labor intensive, and limited by probe placement.

179 ated with higher percentage of interproximal probing pocket depth (P = .004).

180 CP patients associated with >= 6 mm residual probing pocket depth (PPD) were included and randomly as

181 Pre- and post-therapy clinical (probing pocket depth [PPD], clinical attachment level [C

182 III mode disappears when probe polarization aligns perpendicular to b axis.

183 essment was performed, including bleeding on probing, probing depth, and clinical attachment level.

184 II (EDIII) protein was used as the antigenic probe protein in this immunosensing strategy.

185 in labeling (SDSL) ESR is a valuable tool to probe protein systems that are not amenable to character

186 orkflow that involves protein stable isotope probing (protein-SIP) and identification/quantification

187 s traditional approach with experiments that probe proteins in a T-dependent fashion, e.g., for asses

188 Progress in ultrafast science allows for probing quantum superposition states with ultrashort las

189 ation of molecular structures but also local probe reactions, in which unstable short-lived products

190 By probing recent high-resolution structures in the context

191 bust, reliable, and model-based experimental probes; recruit larger sample sizes; and use single case

192 dern machine learning methods may be used to probe relationships along different regions of the predi

193 Structural probing revealed that the RNA binds amino-tSS about 100-

194 Thus, this probe serves as a nondestructive and cost-effective dete

195 We provide a detailed methods protocol, probe sets for >5000 common microbes from RefSeq, and an

196 The probe signal localized intracellularly and at the cell w

197 resent the number of PCR cycles required for probe signal to be detected (low Ct value = high bacilla

198 joins a direct analysis in real time (DART) probe, solid-phase microextraction (SPME) fiber, and the

199 rom previous ones in that they independently probe specific ion binding sites within the selectivity

200 ss the safety and clinical outcomes of multi-probe stereotactic radiofrequency ablation (SRFA) for ve

201 Additional analyses probed stress effects on the dorsal hippocampus (HPC), b

202 lack of high-resolution instruments that can probe structural changes at the atomic and molecular lev

203 roism, which uses vibrational transitions to probe structure, is much less employed.

204 ules, due to the use of reaction schemes and probes/substrates that are not sensitive to the diverse

205 probes for individual SHs are scarce because probe synthesis usually takes place by time-consuming so

206 age defects are inaccessible by most surface-probing techniques.

207 We have developed a caged glutamate probe that is inert toward these receptors at concentrat

208 rt a new photocaged cell-permeable ubiquitin probe that undergoes photoactivation upon 365 nm UV trea

209 cancer, we developed a new class of in situ probes that can be applied to fresh-frozen tissue sectio

210 Fluorescent probes that can discriminate enantiomers of amino acids

211 Modulating the structure gives rise to probes that can enter cells without the aid of transfect

212 design and develop sensitive chiral optical probes that can function within a biological setting.

213 c evaluations led to benzophenone-containing probes that efficiently and selectively captured known C

214 Two proof-of-concept inorganic probes that exploit a novel mechanism for (19) F MR sens

215 e skull that can be used to introduce neural probes that measure and manipulate neural activity.

216 ing oxazonine collection identified chemical probes that regulate mitochondrial membrane potential, a

217 Here, we show that AND-gate optical imaging probes that require the processing of two substrates by

218 Chemical probes that selectively inhibit a single BET bromodomain

219 eration sequencing using molecular inversion probes that targeted mainly coding regions.

220 llography method was successfully adopted to probe the 2-um-thick filaments in situ, being embedded i

221 ydration of tert-butyl alcohol (TBA) used to probe the activities of OH groups of Zr(6)O(8) nodes in

222 nd photoemission studies were carried out to probe the chemical nature of the insulating ground state

223 The field of optics offers valuable tools to probe the chirality of nanosystems, including the measur

224 o be measured directly, using as the primary probe the DNA-binding species with the binding site inac

225 mary metabolism thus offers opportunities to probe the genetic basis of metabolic and phenotypic vari

226 We probe the influence of starting protein structures on th

227 y, here we have employed molecular models to probe the isomerization of azobenzene guests within a Pd

228 Here, we present a new technique to probe the microrheological characteristics of aerosol pa

229 technique, restriction spectrum imaging, to probe the microstructure (cellular density) of subcortic

230 e known CPMG spikelet frequencies allowed to probe the near-absence of quartz in commercial, 100% sil

231 eliability of using primordial abundances to probe the physics of the early Universe.

232 er glutamatergic or cholinergic afferents to probe the relative roles of different signalling mechani

233 important aspect of precision medicine is to probe the stability in molecular profiles among healthy

234 These methods enable us to probe the structure, stoichiometry, and domain interacti

235 Herein, we use osmolytes to probe the structuring and aggregation of the intrinsical

236 cule tracking was employed to simultaneously probe the translational and orientational diffusion of f

237 We probed the effects of excitatory neurotransmitter glutam

238 Using radiofrequency spectroscopy, we probed the energy, spectral width, and short-range corre

239 Herein, we probed the recognition of lysine crotonylation and acety

240 altered receptor dynamics, in this work, we probed the role of the actin cytoskeleton in the dynamic

241 We probed the spatio-temporal dynamics of eCRF modulation u

242 Here, we probed the structure and mechanism of these two enzymes

243 inpoint residues involved in DAB binding, we probed the structure-function relationship of (Pl)EctA b

244 -seq peaks or imputed TR binding sites, Lisa probes the chromatin models using in silico deletion to

245 a widely applied biophysical technique that probes the structure and dynamics of biomolecules withou

246 ATAC-seq has become a leading technology for probing the chromatin landscape of single and aggregated

247 cent deep mutational scanning (DMS) datasets probing the effects of single amino acid variation on en

248 potential to serve as a powerful medium for probing the etiology of developmental disorders associat

249 While probing the nucleobase determinants of 5mC recognition,

250 Probing the physicochemical characteristics of an acidic

251 ort-wavelength surface acoustic waves(4-10), probing the properties of the atom at only a single freq

252 (XAS) has become an indispensable method for probing the structure and composition of heterogeneous c

253 rising in view of the challenges involved in probing the structure of proteins within monomolecular f

254 confirms that using GO modified fiber optic probe, the sensitivity is enhanced to 24% and 37% for gl

255 When light is used as the probe, the standard quantum limit arises from the balanc

256 sistent with a model in which, at the scales probed, the human genome is often free of knots.

257 efforts due to a critical lack of methods to probe their atomic-level microstructure.

258 e and below the bandgap of materials, and to probe their response at the timescale of the fastest non

259 uli in the absence of reward contingency and probing their effects on the processing of separate targ

260 By probing their relationship with AP complexes, we find th

261 Probing their responsive behavior in situ is a challengi

262 Here we probe them in the case of Myoglobin-NO (MbNO) using elem

263 s offers a unique and complementary means to probe these polymers, precisely because they are sensiti

264 We have probed these fundamental questions using the fission yea

265 cure due to a lack of experimental tools for probing these pathways at the molecular level.

266 f example in health disparities research, we probe this "closer engagement of social epidemiology wit

267 e well-known anthracene-boronic acid (An-BA) probe to a biomimetic DNA scaffold and consequently, to

268 maging studies highlight the ability of this probe to detect infection, assess infection burden, and

269 tion of peptides, thus installing a specific probe to study peptide-protein interactions by (19) F NM

270 However, the lack of appropriate probes to bridge both microscopic resolutions restricts

271 e, we used these small molecules as chemical probes to characterize the roles of the different apo(a)

272 We applied both types of tPAINT probes to map integrin receptor forces in live human pla

273 sm of conversion of the boronate-based redox probes to oxidant-specific products.

274 Here we present Hybridization of Probes to RNA for sequencing (HyPR-seq), a method to sen

275 Atom probe tomography of these crystals revealed the presence

276 Chemical sensitivity analysis (CSA) is a new probing tool for sampling sensitivities to chemistry par

277 (3D orientation plus "wobble") of lipophilic probes transiently bound to lipid membranes, revealing t

278 Despite the structural simplicity, the probe turned out to be unprecedentedly highly sensitive

279 Overall, we show that directional TMS can probe two distinct cerebellar-cerebral pathways that lik

280 the signal from distinct fluorophore-labeled probe types in a biplexed NAAT in a glass fiber membrane

281 he synthesis of two ubiquitin activity-based probes (Ub-ABPs) employing solid phase chemical ligation

282 nanoseconds enables critical capabilities of probing ultra-fast phenomena in condensed matter systems

283 Visually induced motion sickness was probed using the Simulator Sickness Questionnaire modifi

284 cing (PORE-cupine), which combines structure probing using chemical modifications with direct long-re

285 obing (>=15 seconds versus <15 seconds after probing versus spontaneous).

286 The chemical origin of this distinction was probed via fluorine K-edge X-ray absorption spectroscopy

287 a positively polarized PDA-modified AFM-SECM probe was 6.2 +/- 2.2 nN, and it was about 50% less (i.e

288 ase chain reaction (qPCR) assay using TaqMan probe was developed to discriminate bovine, porcine and

289 Using these probes, we were able to identify the distribution of fou

290 ne and maternal and fetal catheters and flow probes were implanted to determine cardiovascular and me

291 We find that removal of methylation probes which are correlated with confounder variables re

292 ghly luminescent europium chelate-conjugated probe, which is the key component in sensing the hydroph

293 orescent signal emitted from single-molecule probes, which rapidly degrades resolution with increasin

294 y reports new methodologies to synthesize SH probes, while providing new reagents to study protein de

295 ic tension imaging, we engineered reversible probes with a cryptic docking site revealed only when th

296 examples of small-molecule isoform-selective probes with a focus on the relevance of isoform differen

297 biotic prescriptions require highly specific probes with sensitive and accurate transducers that can

298 duced fluorescence of a superoxide-selective probe within the primordia of tt7-2 compared with wild-t

299 that the linker type and the number of redox probes within the cage are useful handles to fine-tune t

300 tested BAs, the fluorescence response of the probes ZnO@PLP and ZnO@Py showed good linearity to histi