ライフサイエンスコーパス: prochiral

1 n chains are fabricated by polymerization of prochiral 1,3,5-tris(3-bromophenyl)benzene (mTBPB) direc

2 use of 20 different substrates, including 17 prochiral 1,3-dienes and 3 acrylates, this hetero-dimeri

3 f racemic secondary alkyl electrophiles with prochiral 1,3-enynes (in the presence of a hydrosilane)

4 ctive asymmetric cross metathesis (ACM) of a prochiral 1,4-diene was demonstrated.

5 logy of monolayers formed upon adsorption of prochiral 1,5-substituted anthracene derivatives on high

6 is the rhodium(I)-catalyzed rearrangement of prochiral 1,6-heptadienes into [2,2,1]-cycloheptane deri

7 ion about the in-cage motions of the singlet prochiral 1-naphthoxy/1-phenylethyl radical pairs (radic

8 This alkylative desymmetrization of prochiral 2,2-disubstituted cyclopentene-1,3-dione is ca

9 ation via remote C(sp(2))-H amidation of the prochiral 2,2-disubstituted cyclopentene-1,3-dione with

10 vinylogous Michael/aldol tandem reaction of prochiral 3-alkylidene oxindoles with methyleneindolinon

11 ization via an unidentified bonding motif of prochiral 9-ethynylphenanthrene (9-EP) upon annealing to

12 (syn or anti) when prochiral radicals add to prochiral acceptors is of fundamental interest.

13 electivity in prochiral radical additions to prochiral acceptors.

14 egation at the molecular level by chiral and prochiral adsorbates on surfaces.

15 lysts for the enantioselective alkylation of prochiral aldehydes has been determined by simultaneous

16 f reaction of diethyl acetylphosphonate with prochiral aldehydes in the presence of a catalytic syste

17 lting vinylzinc reagents add to a variety of prochiral aldehydes to produce racemic (Z)-trisubstitute

18 of (Z)-trisubstituted vinylzinc reagents to prochiral aldehydes with a (-)-MIB-based catalyst has al

19 and N-bromosuccinimide efficiently converts prochiral alkenes into a readily separable 1:1 mixture o

20 ilized asymmetric hydroformylation (iAHF) of prochiral alkenes.

21 xidative homolysis of the C-B bond generates prochiral alkyl radicals, which are functionalized by in

22 Here, competing reactions of a prochiral alkyne on Ag(111): two-dimensional (2D) homoch

23 s the cyclizations of 4-allen-1-ols into one prochiral allene face.

24 on/remote alpha-allylation/1,3- migration of prochiral allyl carbonate-tethered cyclohexadienones in

25 hanisms involving prochiral nucleophiles and prochiral allyl fragments.

26 f enantioenriched chiral allylic amines from prochiral allylic alcohols.

27 s-coupling was investigated with substituted prochiral allylic boronates.

28 sized and evaluated for the rearrangement of prochiral allylic N-(4-methoxyphenyl)benzimidates.

29 e assembly of quaternary stereocenters using prochiral allylic substrates and hard, achiral nucleophi

30 tive rhodium-catalyzed allylic alkylation of prochiral alpha,alpha-disubstituted aldehyde enolates wi

31 markable growth in methods forming these via prochiral alpha-amino radical intermediates.

32 ectivity, while the Pro242 residue locks the prochiral alpha-CH2, thereby leading to hydroxylation of

33 enzymatic oxidative desymmetrization of the prochiral amine substrate.

34 c gelatin and kappa-carrageenan gels and the prochiral and chiral isotopomers.

35 h an appropriately designed rotaxane between prochiral and mechanically planar chiral forms.

36 As substrates, four prochiral and one chiral 3,6-dihydro-2H-1,4-thiazines we

37 The adsorption orientation of these prochiral anthracene derivatives positions one of their

38 facilitates catalytic [1,2]-rearrangement of prochiral aryl ester ammonium salts to generate unnatura

39 catalyst for the asymmetric hydrogenation of prochiral aryl imines activated with N-diphenylphosphino

40 diastereoselectivity of bond formation at a prochiral attached-ring bridgehead is reported.

41 ises when a prochiral macrocycle encircles a prochiral axle.

42 alytic asymmetric alpha-functionalization of prochiral barbituric acids, a subtype of pseudosymmetric

43 ) catalyzed nucleophilic desymmetrization of prochiral, bench stable P(V) precursors and subsequent e

44 stic investigation indicated a discriminated prochiral binding of the N-arylamine substrates onto the

45 NMR spectra of mixtures of racemic mono- and prochiral bis-deuterated glycine-2-(13)C were resolved a

46 Combining the desymmetrization of a prochiral bis-hydroxymethyl group with the epimerization

47 eparing complex natural products from simple prochiral building blocks and present tandem catalysis i

48 ed heterogeneous asymmetric hydrogenation of prochiral C horizontal lineO and C horizontal lineC bond

49 -Boc aldehyde 32 and then converted into the prochiral C(16)-quaternary diol 12 via the practical Tol

50 mmense importance due to the highly reactive prochiral C-3 position, which paves an easy way to const

51 transfer from the chiral thiol catalyst to a prochiral C-centered radical.

52 t enable asymmetric palladium insertion into prochiral C-H bonds on a single methylene carbon center.

53 reactions often rely on desymmetrization of prochiral C-H bonds on the same achiral molecule, using

54 for the presence of two chemically identical prochiral C-H bonds represents an inherent limitation in

55 ot be accessible through desymmetrization of prochiral C-H bonds.

56 including an identification of homotopic and prochiral carbon atoms; and a bijective map relating the

57 ed with strained bicyclobutanes (BCBs) and a prochiral carbon electrophile in a three-component react

58 by carbon-carbon bond formation results in a prochiral carbon-centered radical that engages with the

59 Effective differentiation of prochiral carbon-hydrogen (C-H) bonds on a single methyl

60 e revealed an active site that discriminates prochiral carboxylates and accommodates the large size a

61 a P-chiral phosphinyl moiety at Cbeta to the prochiral center and (R)- or (S)-Difluorphos.

62 cycle shuttling between different sides of a prochiral center, creating point chirality in the vicini

63 In reactions at a prochiral center, modest diastereoselectivities were obs

64 s within molecules that are removed from the prochiral centers by long distances presents special cha

65 A challenge is the control of prochiral centers with similar electronic properties in

66 hieved from Michael acceptors containing two prochiral centers.

67 o allow stereospecific electroreduction of a prochiral compound, with very significant enantioselecti

68 mbined with simultaneous desymmetrization of prochiral cyclic anhydrides (1).

69 ved primary amine organocatalyst, a range of prochiral cyclohexanone derivatives possessing an alpha,

70 tween N-phenacylbenzothiazolium bromides and prochiral cyclopentene-1,3-diones.

71 propylcarboxaldehydes from readily available prochiral cyclopropenes.

72 esymmetrizing, annulative C-H activations of prochiral diarylmethylphenyl amides, and thus obtain the

73 an ortho substituent on one phenyl ring of a prochiral diazo enhances enantioselectivity up to 95:5 e

74 silanes were evaluated with symmetrical and prochiral diazo reactants to produce a total of 25 novel

75 to direct the addition of thiophenolate to a prochiral dichloropyrimidine by a tandem desymmetrizatio

76 se the first catalytic desymmetrization of a prochiral dienoic acid by enantioselective bromolactoniz

77 highly functionalized scaffolds containing a prochiral dienone system, a quaternary carbon center con

78 The desymmetrization of prochiral diesters with a chiral phosphoric acid catalys

79 The pendant, prochiral difluoride groups R-N=(O=)SF2 , in turn, offer

80 Catalytic enantioselective hydroxylation of prochiral dihydrosilanes with water is expected to be a

81 ctive enzymatic desymmetrization reaction of prochiral diol 12 using a commercially available Pseudom

82 The desymmetrization of ten prochiral diols by phosphoryl transfer with a titanium-B

83 trization by direct monofunctionalization of prochiral diols is a powerful strategy to prepare valuab

84 Desymmetrization of prochiral diols provides axially chiral biaryl compounds

85 In some cases, a prochiral directing group is not required and the first

86 ric induction are achieved from a mixture of prochiral (E)- and (Z)-enolates, which provides an excit

87 luated as catalysts for the rearrangement of prochiral (E)-allylic trichloroacetimidate 19 (eq 2) and

88 y trapping the lithiated intermediate with a prochiral electrophile (e.g., pivaldehyde or tBuPCl(2)).

89 enolate resulting from Michael addition with prochiral electrophiles, such as aldehydes or N-sulfonyl

90 mechanism of the asymmetric hydrogenation of prochiral enamides by well-defined, neutral bis(phosphin

91 -((iPr)DuPhos)Co]-catalyzed hydrogenation of prochiral enamides.

92 The enantioselective protonation of prochiral enolates is an ideal and straightforward platf

93 ium-catalyzed allylic alkylation reaction of prochiral enolates to form an all-carbon quaternary ster

94 employing a novel asymmetric reduction of a prochiral enone to afford an allylic alcohol with high e

95 = 1-alkylimidazole, pyridine, PMe3, arene is prochiral) exist as a dynamic equilibrium of coordinatio

96 ender the migration of the Pd-aryl to the si prochiral face of the cyclic alkene more preferred over

97 The ACs in this site have the same prochiral face protected by the protein, and this protec

98 at the energetic preference toward the alpha prochiral face stems from reduced skeletal distortions o

99 s compared to that in the corresponding beta prochiral face.

100 uided approach of nucleophiles to one of the prochiral faces of carbocations affording high enantioco

101 ergies of the respective coordination of the prochiral faces of the arene determined by steric intera

102 ement, which is selective with regard to the prochiral faces of the intermediate enolate.

103 Alkenes are the most ubiquitous prochiral functional groups--those that can be converted

104 Use of prochiral, heteroatom-substituted radicals results in st

105 allylic alkylation (Pd-AAA) of nucleophilic prochiral heterocycles.

106 The chemical shifts of the prochiral hydrogens of authentic (3R)-beta-phenylalanine

107 l group to effectively shield one of the two prochiral hydroxy groups on the diol complex, whereas a

108 for the asymmetric transfer hydrogenation of prochiral imines using [Cp*Ir(biot-p-L)Cl] as cofactor.

109 re achieved for the reduction of challenging prochiral imines.

110 n-2,4'-piperidine]-1'-carboxylate, a central prochiral intermediate in the synthesis of SHP2 inhibito

111 transformed into cyclohexene products via a prochiral intermediate ring opened enone; which then und

112 The interconversion, resulting in prochiral inversion of the alpha-ketoester, occurs in si

113 Such sulfonimidamides can readily generate prochiral ions, which we have exploited in an enantiosel

114 -prototropic shift of beta,gamma-unsaturated prochiral isomers, under mild reaction conditions and in

115 ntramolecular Michael addition reaction of a prochiral ketone to a tethered beta,beta'-disubstituted

116 Enantioselective reductions of two prochiral ketones have been carried out using the origin

117 that purpose a series of racemic amines and prochiral ketones have been synthesized from commerciall

118 s used as catalysts for the hydrogenation of prochiral ketones in water at room temperature and 4 bar

119 Catalytic asymmetric reduction of prochiral ketones of type 4-alkylidene cyclohexanone wit

120 ymmetric reduction of phenyl ring-containing prochiral ketones to yield the corresponding optically a

121 The asymmetric direct reductive amination of prochiral ketones with aryl amines using 1-hydrosilatran

122 shown to be applicable to a wide variety of prochiral ketones.

123 allows stereocontrol in the self-assembly of prochiral ligand scaffolds.

124 eogenic unit in rotaxanes that arises when a prochiral macrocycle encircles a prochiral axle.

125 In 1971, Schill recognized that a prochiral macrocycle encircling an oriented axle led to

126 ere the generalized order parameters of both prochiral methyl groups were determined, the pro-R methy

127 tion into the C(sp(3))-H bonds of one of the prochiral methyl groups.

128 reaction of o-sulfinylbenzyl carbanions with prochiral Michael acceptors, such as differently sized c

129 r spectrum corresponds to that of an average prochiral molecule and may exhibit enantiotopic sites.

130 reveal enantiotopic discrimination in guest prochiral molecules are also described and compared with

131 nantiomers, of enantiomeric mixtures, and of prochiral molecules on chiral and achiral model surfaces

132 terms of adsorption-induced chirality in the prochiral molecules on the silver nanoparticles.

133 h interconversion, leading to electronically prochiral molecules that can be converted from achiral t

134 ectra originating from enantiotopic sites in prochiral molecules when dissolved in chiral solvents is

135 The chemisorption of prochiral molecules, such as adenine, on a metal surface

136 Stereoselective polymerization of chiral or prochiral monomers is a powerful method to produce high-

137 lic carbene (NHC) ligands were prepared from prochiral NHC precursors.

138 bond formation between a benzyl group and a prochiral nucleophile to generate a quaternary center.

139 of the asymmetric Tsuji allylation involving prochiral nucleophiles and nonprochiral allyl fragments,

140 hed allylation reaction mechanisms involving prochiral nucleophiles and prochiral allyl fragments.

141 ghts the complementary approaches with soft, prochiral nucleophiles catalyzed by chiral cobalt and ni

142 metrization that employs phosphinic acids as prochiral nucleophiles in a Pd-catalyzed asymmetric ally

143 ion has been demonstrated with azlactones as prochiral nucleophiles in the presence of chiral bisphos

144 conducting diastereoselective reactions with prochiral nucleophiles in the presence of metallacyclic

145 benzylic alkylation with 3-aryl oxindoles as prochiral nucleophiles.

146 catalytic enantioselective hydrogenation of prochiral olefins is a key reaction in asymmetric synthe

147 the asymmetric Rh-catalyzed hydrogenation of prochiral olefins using these ligands, enantiomeric rati

148 ive lactonization affect desymmetrization of prochiral or meso-diols, and processes where C-C bond fo

149 the synthesis of stereoblock polyesters from prochiral or racemic monomers outside of "simple" isotac

150 In this scenario, both faces of the prochiral oxocarbenium ion are subject to nucleophilic a

151 approaches to enantioselective additions to prochiral oxocarbenium ions.

152 of intermediates containing vinylgold(I) and prochiral oxocarbenium moieties.

153 l to their preparation was conversion of the prochiral parent bisphosphonic acids to the P,C-dimorpho

154 iral PCB metabolites are formed from axially prochiral PCB congeners, a fact that should be considere

155 owever, the formation of chiral OH-PCBs from prochiral PCBs has not been demonstrated experimentally.

156 ditionally, the oxidation of certain axially prochiral PCBs, such as 2,2',4,6'-tetrachlorobiphenyl (P

157 A concise preparation of the prochiral pentacyclic core of (+)-salvileucalin B is pre

158 ties that can be used to identify one of the prochiral phosphate oxygens as a critical site for compl

159 y to probe for interactions to either of the prochiral phosphate oxygens as illustrated by their use

160 The prochiral photoketene hemiacetals are procured from exci

161 ologs containing deuterium at C-6 or the two prochiral positions at C-7.

162 t parahydrogen could be rapidly added to the prochiral precursor to both enantiomers of lactic acid (

163 The two prochiral primary alcohols in diol 17 were differentiate

164 e, the allylic rearrangement of both E and Z prochiral primary allylic N-(4-methoxyphenyl)benzimidate

165 highly enantioselective desymmetrization of prochiral propargylic alcohols.

166 C-N bond formation and desymmetrization of a prochiral quaternary center are independently controlled

167 ary to achieve high levels of selectivity in prochiral radical additions to prochiral acceptors.

168 s photoenzymatic process effectively directs prochiral radical centres located more than six chemical

169 ogen atom from the flavin semiquinone to the prochiral radical formed after cyclization provides high

170 mpact on the levels of stereoinduction, as a prochiral radical intermediate is planar, with two ident

171 hieving stereochemical control of the remote prochiral radical intermediate(7).

172 ve stereocenters through the intermediacy of prochiral radical species.

173 After formation of a prochiral radical, the enzyme guides the delivery of a h

174 stereochemical preference (syn or anti) when prochiral radicals add to prochiral acceptors is of fund

175 ween stereochemical states and find that the prochiral reagent can sample several complexation geomet

176 uctures of complexes formed between adsorbed prochiral reagents and chiral molecules yield informatio

177 ctive lipase-catalyzed acrylation along with prochiral selection of 4-C-hydroxymethyl-1,2-O-isopropyl

178 Fourteen prochiral silanes were evaluated with symmetrical and pr

179 tioenriched silicon center is achieved using prochiral silanes.

180 genic centers are created by functionalizing prochiral sites under thermodynamic control, and remote

181 The assignment of the prochiral sites was derived from chiral analogues.

182 eferred hydrolysis from the sn-1 position of prochiral sn-1,3-DG regioisomer, whereas PFL exhibited n

183 , thereby converting these readily available prochiral starting materials into highly enantiomericall

184 of axially chiral disubstituted allenes from prochiral starting materials remains a long-standing cha

185 Oxidation of the prochiral substrate cumene by CYP4B1, but not CYP2B1 or

186 h involves the addition of parahydrogen to a prochiral substrate with a chiral catalyst followed by p

187 c, coplanar conformation with respect to the prochiral substrate, and reaction occurs preferentially

188 Prochiral substrates may undergo diastereoselective hydr

189 ther generating new stereogenic centres from prochiral substrates or resolving racemic mixtures of en

190 Asymmetric hydrogenation of prochiral substrates such as ketones and olefins constit

191 The prochiral substrates were desymmetrized with up to an ex

192 routes to axially chiral allenes (ACAs) from prochiral substrates, a mechanistically distinct reactio

193 Our data suggest that for prochiral substrates, the step that determines the enant

194 lectivity in the asymmetric sulfoxidation of prochiral thioethers.

195 metathesis (ARCM) of a challenging class of prochiral trienes has also been achieved.

196 Such cages were self-assembled by prochiral trispyridine ligand L based on a C(3h) truxene

197 ic helix-sense-selective polymerization of a prochiral vinyl monomer, which provides access to optica

198 onic helix-sense-selective polymerization of prochiral vinyl monomers, which limits access to a numbe

199 eductase biocatalyzed conjugate reduction of prochiral vinyl sulfides.

200 ve synthesis of branched allylic esters from prochiral (Z)-2-alkene-1-ols has been developed.

201 )2' allylic substitution of acetic acid with prochiral (Z)-allylic trichloroacetimidate 23.