ライフサイエンスコーパス: profibrotic

1 al inhibition of alphaV-integrin reduced the profibrotic action of cardiac PW1(+)CD51(+) cells and wa

2 In the current work we show that the profibrotic actions of TGF-beta are mediated, at least i

3 gulation in fibroblasts is implicated in the profibrotic actions of transforming growth factor-beta (

4 roinflammatory (3 d) to an anti-inflammatory/profibrotic activation state, along with serial elaborat

5 TGF-beta has potent profibrotic activity in vitro and has long been implicat

6 le the TAT-SNX9 peptide prevented TGF-beta's profibrotic activity in vitro as well as in 2 murine tre

7 n, and targeting its activity attenuated the profibrotic activity of these cells both in vitro and in

8 Recent findings have highlighted the profibrotic activity of tissue-resident macrophages in t

9 pericytes, but domain 4 showed the broadest profibrotic activity.

10 nstream target of TGF-beta that mediates its profibrotic activity.

11 flammatory molecule IL-1beta, as well as the profibrotic agent TGF-beta by this portion of the nephro

12 Coupling topographical cues with the profibrotic agonist, TGFbeta (transforming growth factor

13 RP78 in regulating high glucose (HG)-induced profibrotic AKT Ser/Thr kinase (AKT) signaling and up-re

14 e identified a distinct, novel population of profibrotic alveolar macrophages exclusively in patients

15 5-HT(7) drives the acquisition of profibrotic and anti-inflammatory functions in M-MO, whe

16 in SSc fibroblasts and endothelial cells is profibrotic and antiangiogenic.

17 omerular injury; decreased the expression of profibrotic and fibrotic components, including fibronect

18 aR differentially inhibited bacteria-induced profibrotic and inflammatory mediator production by peri

19 nced ROS production, increased expression of profibrotic and proinflammatory mediators, and increased

20 rstitial myofibroblast activation, including profibrotic and proinflammatory paracrine signals secret

21 led that miR-21 and miR-221, 2 activators of profibrotic and proliferative processes, increased the m

22 R2 ligands, which drive fibroblasts toward a profibrotic and senescent phenotype.

23 IL-13 is profibrotic, and it is released in a higher amount in pa

24 ariance in protein abundance associated with profibrotic, apoptosis, and antioxidant proteins.

25 rpose of this study was to determine whether profibrotic biomarkers accurately reflect the presence a

26 At baseline, the profibrotic biomarkers aldosterone, sST2, TIMP-1, Gal-3,

27 le AF secondary to altered expression of key profibrotic biomarkers that is independent of the presen

28 U-IRI revealed high-level expression of the profibrotic BRP-39 receptor Ptgdr2/Crth2 and expression

29 erging data indicating a role for T cells in profibrotic cardiac repair and healing after ischemia, l

30 uscle actin-expressing myofibroblasts, a key profibrotic cell population.

31 nobufagenin binding to Na/K-ATPase initiates profibrotic cell signaling, and heightened marinobufagen

32 cyte-derived fibrocyte, a collagen-secreting profibrotic cell.

33 mesenchymal stem cells or human hepatogenic profibrotic cells activated by transforming growth facto

34 ibrosis is a common disease process in which profibrotic cells disturb organ function by secreting di

35 sociated with metabolic dysfunction, but how profibrotic cells originate is still being elucidated.

36 esenchymal stem cells, and human hepatogenic profibrotic cells.

37 treatment that promote the development of a profibrotic cellular microenvironment.

38 r translocation and transcription of a major profibrotic collagen gene.

39 Cells were cultured on profibrotic conditions including stiff substrata and TGF

40 Because secretion of the profibrotic connective tissue growth factor (CCN2) incre

41 +)CD28(-) T cells produce high levels of the profibrotic cytokine IL-13, which induces collagen produ

42 ion mediated by T cell recruitment and local profibrotic cytokine release.

43 gulate many genes that are suppressed by the profibrotic cytokine TGF-beta, whereas many PGE2-downreg

44 s of adipocyte state loss in response to the profibrotic cytokine TGF-beta.

45 fibrosis, a central mediator of which is the profibrotic cytokine TGF-beta.

46 in primary MCs, and was up-regulated by the profibrotic cytokine transforming growth factor-beta1 an

47 We showed that the major profibrotic cytokine, TGF-beta1 promoted rapid Rac1-GTP

48 lated by application of TGF-beta1, the major profibrotic cytokine, thereby suppressing downstream mTO

49 accelerated secretion of proinflammatory and profibrotic cytokines (interleukin-2, interferon-gamma,

50 is related genes, such as several collagens, profibrotic cytokines and matrix metalloproteinases.

51 HF MyoFb express high levels of profibrotic cytokines and the TGF-beta1 pathway is activ

52 acoid feedback inhibition of proinflammatory/profibrotic cytokines by T cell-derived CD73.

53 ocyte expression of both proinflammatory and profibrotic cytokines was significantly higher in mdx(5c

54 is and steatohepatitis, more proinflammatory/profibrotic cytokines, and a higher incidence of hepatic

55 l sources and release of proinflammatory and profibrotic cytokines, and a manifestation of organ dysf

56 reous showed upregulation of T-cell markers, profibrotic cytokines, and cytokines downstream of mTOR

57 Both antigen-specific CD8(+) T cells and profibrotic cytokines, such as TNFalpha and IL-13, are e

58 omposition correlate with increased alveolar profibrotic cytokines.

59 and the accumulation of proinflammatory and profibrotic cytokines.

60 which contribute to the disease by secreting profibrotic cytokines.

61 sis that HIF-1alpha mediates albumin-induced profibrotic effect in cultured renal proximal tubular ce

62 es localized to the fibrotic niche and had a profibrotic effect in vivo.

63 tion rescues eNOS levels and ameliorates the profibrotic effect of endothelial cells in vitro.

64 cate that higher CXCL4 expression in MPN has profibrotic effects and is a mediator of the characteris

65 d the mechanism by which TGF-beta exerts its profibrotic effects and specifically the role of AMP-act

66 e HIF-1alpha, which mediates albumin-induced profibrotic effects in renal tubular cells.

67 The main mechanism of TSLP profibrotic effects is not as yet fully understood, alth

68 From a clinical perspective, the profibrotic effects of PDGF-CC outweigh the pro-angiogen

69 es and primary cells and is required for the profibrotic effects of TGF-beta.

70 We found that DMF blocks the profibrotic effects of transforming growth factor-beta (

71 '-diphosphate (UDP)] have been shown to have profibrotic effects, as well.

72 llenge and the IL-2 complex had no effect on profibrotic (eg, transforming growth factor-beta) or typ

73 the genetic deletion of MARCO attenuated the profibrotic environment and pulmonary fibrosis in mice e

74 hese findings suggest that Ybt establishes a profibrotic environment in the host in the absence of bi

75 translocation, might be a sign of a diseased profibrotic epithelial phenotype.

76 arget genes expressed in the skin, including profibrotic extracellular matrix collagens.

77 subunits of collagen types I and VI, and the profibrotic factor alpha-smooth muscle actin compared wi

78 Mechanistically, the profibrotic factor TGF-beta1 induced hypermethylation an

79 transforming growth factor-beta) is the main profibrotic factor, but its inhibition is associated wit

80 lpha), hypertrophic factors (e.g., ANP), and profibrotic factors (e.g., TGFbeta1) from both VCM and v

81 s a key role in epigenetic regulation of key profibrotic factors in diabetes.

82 Injury-induced epithelial secretion of profibrotic factors is hypothesized to underlie this lin

83 vitro treatment of IPF fibroblasts with the profibrotic factors TGF-beta1 or tumor necrosis factor a

84 g those of Tgfb1, Tgfb3, and Ctgf, the major profibrotic factors that are known to drive diabetic ren

85 expression of a specific subset of paracrine profibrotic factors, including Lcn2, Pdgfb, and Timp1.

86 reduced necrosis, and limited expression of profibrotic factors, suggesting that pharmacologic purin

87 itochondria depolarization and expression of profibrotic factors.

88 rocyte-neuronal communication in response to profibrotic factors.

89 e a therapeutic target to short-circuit this profibrotic feedback loop.

90 fibrosis, largely through their promotion of profibrotic fibroblast activation.

91 ice have linked high expression of CD26 to a profibrotic fibroblast phenotype, but this has not been

92 rsed fibrosis, by increasing phagocytosis of profibrotic fibroblasts and by eliminating suppressive e

93 in differentiation of pluripotent cells into profibrotic fibroblasts and the potential for C-82 with

94 However, engrailed1 profibrotic fibroblasts, responsible for scar extracellu

95 regulatory role of microRNA (miR)-155 in the profibrotic function of murine lung macrophages and fibr

96 knockdown results in significant decrease in profibrotic functions, including myofibroblast contracti

97 ial fibrosis and attenuates hypertrophic and profibrotic gene expression in mice harboring heterozygo

98 ate the role of PDGFRalpha on proliferation, profibrotic gene expression, and migration in primary hu

99 ased LV cardiomyocyte size, hypertrophic and profibrotic gene expression, and upregulation of LV supe

100 a-stimulated fibrogenic processes, including profibrotic gene expression, cell migration, colony form

101 ice was analyzed by histology, collagen, and profibrotic gene expression.

102 enuated the diabetes-induced upregulation of profibrotic gene markers, fibronectin and transforming-g

103 f rapid conduction genes and upregulation of profibrotic gene programming, whereas analysis of a gain

104 4, Etv1, Scn5a, and Gja5 and upregulation of profibrotic gene programming, which includes Tgfbr1/2, I

105 family transcription factor, as a candidate profibrotic gene that drives the final common pathologic

106 stress fibers, and reduces the expression of profibrotic genes and cytokines levels to non-HF levels.

107 p dose-dependently reduced the expression of profibrotic genes and inhibited migratory activity of SS

108 volume/mass ratio, and blunts expression of profibrotic genes and interstitial fibrosis in mice subj

109 helium resulted in upregulated expression of profibrotic genes and TIF.

110 s associated with an increased expression of profibrotic genes and transforming growth factor-beta si

111 h expression of combined proinflammatory and profibrotic genes are associated with a poor response to

112 cells (HSCs), reduces expression of Gli3 and profibrotic genes but induces gfap, the inactivation mar

113 ular mechanisms for translational control of profibrotic genes during cardiac fibrosis remain unclear

114 Human homologues of profibrotic genes expressed by mouse monocyte-derived al

115 anslational activation of proline codon rich profibrotic genes in cardiac fibroblasts and augments pa

116 gulated the constitutive expression of these profibrotic genes in IPF fibroblasts.

117 Increased protein synthesis of profibrotic genes is a common feature in cardiac fibrosi

118 that mEVs are enriched for miRs that target profibrotic genes up-regulated in IPF fibroblasts.

119 -induced upregulation of proinflammatory and profibrotic genes was significantly greater in the kidne

120 In addition, expression of these profibrotic genes was significantly higher in the cocult

121 tion via control of H3K27 acetylation at the profibrotic genes, ACTA2 and COL1A1 Genomic analysis rev

122 uptake, upregulation of proinflammatory and profibrotic genes, and development of fibrosis in respon

123 modeling in Pirb(-/-) eosinophils, including profibrotic genes, genes promoting epithelial-to-mesench

124 us Red staining and increased mRNA levels of profibrotic genes, including connective tissue growth fa

125 ere associated with changes in expression of profibrotic genes, including TGFbeta and TIMP1.

126 SC activation entails enhanced expression of profibrotic genes, increase in proliferation, and increa

127 a1-induced SMAD3 activation and induction of profibrotic genes, supporting a positive feedback loop l

128 red phagocytosis, and enhanced expression of profibrotic genes.

129 alveolar macrophages in their expression of profibrotic genes.

130 gram that results in increased expression of profibrotic genes.

131 osis), and expression of proinflammatory and profibrotic genes.

132 TGF-beta1-p53 cooperativity regulates a profibrotic genomic program in the kidney: molecular mec

133 ed following U-IRI, as did the expression of profibrotic growth factors and proimflammatory cytokines

134 a low level of collagens but a high level of profibrotic growth factors as compared with i.m. fibrobl

135 Fibrocyte expression of collagens and profibrotic growth factors was not increased in Ccr2(-/-

136 tly fewer macrophages, reduced expression of profibrotic growth factors, and decreased accumulation o

137 m a quiescent state partially in response to profibrotic growth factors.

138 ocal bioavailability of antihypertrophic and profibrotic growth factors.

139 In summary, LXA4 attenuated profibrotic HLMF activity and promoted HLMF regression t

140 such as NF-kappaB activation and release of profibrotic IL-6.

141 MI altered leaflet adaptation, including a profibrotic increase in valvular cell activation, CD45-p

142 ls can promote lung fibrosis by regulating a profibrotic inflammatory cytokine network.

143 anoma, CCN2 expression was associated with a profibrotic integrin alpha (ITGA) 11-expressing subset o

144 erived TGF-beta1 signaling is increased in a profibrotic ischemia reperfusion and cardiotoxin muscle

145 rmal skin fibroblasts, mimicking the typical profibrotic keloid profile.

146 tor for asbestos, polarizes macrophages to a profibrotic M2 phenotype, and is required for the develo

147 ulator in driving an alternatively activated profibrotic macrophage phenotype in UUO-induced CKD.

148 rat epoxygenase Cyp2j4 as a determinant of a profibrotic macrophage transcriptome that could have imp

149 h1 differentiation and renal accumulation of profibrotic macrophages.

150 ases clearance of fluid and cells, including profibrotic macrophages.

151 d mRNA expression of hypertrophy-related and profibrotic marker genes, without affecting intracellula

152 ine reduced the expression of genes encoding profibrotic markers (collagenIotaalpha1, EDA-fibronectin

153 ferentiation decreased the expression of the profibrotic markers fibronectin and hypoxia-inducible fa

154 ced albuminuria, and inhibited expression of profibrotic markers in animal models with lupus nephriti

155 -KG restored TGF-beta1-induced expression of profibrotic markers in GLS1-deficient myofibroblasts.

156 ndothelial dysfunction and the expression of profibrotic markers in the heart.

157 receptor Ptgdr2/Crth2 and expression of the profibrotic markers Lgals3, Pdgfb, Egf, and Tgfb In comp

158 sed expression levels of proinflammatory and profibrotic markers that were independent of glycemic an

159 ib significantly reduced the upregulation of profibrotic markers, phosphorylation of Smad3, and renal

160 lized to HSC and increased the expression of profibrotic markers.

161 n, abrogated TGF-beta1-induced expression of profibrotic markers.

162 and inhibited mRNA expression of a number of profibrotic markers.

163 ss in trans by giving rise to three distinct profibrotic mature miRNAs (i.e., miR-199a-5p/3p and miR-

164 Profibrotic mechanisms are controlled by multiple regula

165 -derived growth factor (PDGF)-CC as a potent profibrotic mediator in kidney fibrosis and pro-angiogen

166 tify soluble ephrin-B2 (sEphrin-B2) as a new profibrotic mediator in lung and skin fibrosis.

167 We hypothesized that FGF15/19 functions as a profibrotic mediator or mitogen to HSCs and increased BA

168 onclusion: FGF15/19 does not act as a direct profibrotic mediator or mitogen to HSCs in our models, a

169 knockdown of FKBP10 attenuated expression of profibrotic mediators and effectors, including collagens

170 umulated in organized clusters and expressed profibrotic mediators at >/=25 wk after irradiation (fib

171 cent cells and secreting proinflammatory and profibrotic mediators in all renal compartments, even at

172 AMs, cell differentiation, and production of profibrotic mediators.

173 ween HA, CD73/adenosine signaling, and other profibrotic mediators.

174 itor 1B (p27Kip1) and of proinflammatory and profibrotic mediators.

175 renal mRNA expression of proinflammatory and profibrotic mediators.

176 cluding cell proliferation and production of profibrotic mediators.

177 eased FXR activity and reduced expression of profibrotic mediators.

178 ) injury is a key step that contributes to a profibrotic microenvironment.

179 neration, but chronic inflammation creates a profibrotic milieu that exacerbates disease progression.

180 RNAseq revealed induction of a profibrotic miRNA network.

181 p, miR-132, and miR-212) and upregulation of profibrotic miRNAs (miR-142, and miR-147).

182 switch-like mechanism between adipogenic and profibrotic molecular states.

183 essing activation and expression of multiple profibrotic molecules and increasing expression of antif

184 ates to the nucleus to regulate synthesis of profibrotic molecules.

185 ecretion of a variety of proinflammatory and profibrotic molecules.

186 nstream pathways that are important for full profibrotic myofibroblast functionality.

187 ation is essential to support TGFbeta-driven profibrotic myofibroblast functions and excessive wound

188 of downstream RhoA signaling and influences profibrotic myofibroblast functions, including myosin li

189 F-beta in lung myofibroblasts and a distinct profibrotic myofibroblast phenotype driven by stimulatio

190 nhibits the transition of fibroblasts toward profibrotic myofibroblasts in response to transforming g

191 everity and form part of a TGF-beta1-induced profibrotic network.

192 No indices of electrical, profibrotic, or connexin remodeling were noted in POAF,

193 t converts vasculoprotective pantethine into profibrotic pantothenic acid and pro-oxidant cystamine,

194 reduces eNOS expression, thereby mediating a profibrotic paracrine response in fibroblasts.

195 ase gene therapy prevented the onset of lung profibrotic pathologies.

196 ema skin samples showed significantly higher profibrotic pathway levels (transforming growth factor b

197 s and the activation of Th2 inflammatory and profibrotic pathways in experimental animals provide a p

198 BM fibrosis, and decreases the activation of profibrotic pathways in megakaryocytes, inflammation in

199 significantly attenuated TGF-beta1-mediated profibrotic pathways in vitro and in vivo, while esculet

200 These results provide novel insight into profibrotic pathways mediated by TL1A paralleling its pr

201 Activation of these profibrotic pathways was additive following HIV/HCV coex

202 s associated with genes involved in multiple profibrotic pathways, and broad transcriptomic and prote

203 brosis were enriched for proinflammatory and profibrotic pathways.

204 regulation of ERalpha and ERalpha-activated profibrotic pathways.Methods: ER expression in male lung

205 gnaling increases that trigger production of profibrotic peptides, proliferation of interstitial fibr

206 cell chemotaxis resulting in attenuation of profibrotic perivascular inflammation.

207 MCU expression polarized macrophages to a profibrotic phenotype after exposure to asbestos, and th

208 red for the polarization of macrophages to a profibrotic phenotype as mutation of these residues redu

209 transition (MesoMT), whereby they acquire a profibrotic phenotype characterized by increased express

210 roblasts (SFBLs), and this associates with a profibrotic phenotype distinct from gingival fibroblasts

211 , enforced expression of miR-155 reduced the profibrotic phenotype of IPF and miR-155(-/-) fibroblast

212 Retinoid overload helps explain the profibrotic phenotype of Lxralphabeta(-/-) mice, and we

213 The profibrotic phenotype of SFBLs partially depended on exp

214 that BAL cells from patients with IPF have a profibrotic phenotype secondary to increased activation

215 fter injury rapidly adopt a proinflammatory, profibrotic phenotype that expresses Arg1, before transi

216 acrophages toward an alternatively activated profibrotic phenotype, which promotes collagen productio

217 reas the CD11b(+)/Ly6C(low) population had a profibrotic phenotype.

218 jured tubules acquired a proinflammatory and profibrotic phenotype; moreover, AKI dramatically modifi

219 and its loss as observed in IPF facilitates profibrotic phenotypic changes.

220 on was substantially increased, resulting in profibrotic polarization by increasing flux through the

221 Profibrotic polarization was abrogated when MCU was abse

222 henotype after exposure to asbestos, and the profibrotic polarization was regulated by MCU-mediated A

223 lize the mitochondrial calcium uniporter for profibrotic polarization.

224 ess higher amounts of MARCO and have greater profibrotic polarization.

225 feration, and potentiated antiangiogenic and profibrotic properties.

226 creased expression of SOCS7, and increase in profibrotic proteins and miR-199a-3p.

227 ectly suppressing proinflammatory cytokines, profibrotic proteins, and proliferation of lung fibrobla

228 and promotes TGFbeta-1-induced expression of profibrotic proteins, such as fibronectin (FN) and alpha

229 was used to explore expressions of relevant profibrotic proteins.

230 ved nicotine on cellular functions including profibrotic response and other functional aspects is not

231 model of hepatic fibrosis, C9 attenuated the profibrotic response at 1 muM.

232 scriptional coregulator of several TGF-beta1 profibrotic response genes by complexing with receptor-a

233 human skin but not in gingiva may drive the profibrotic response leading to excessive scarring.

234 C termini of csGRP78 were necessary for this profibrotic response.

235 Here, we investigated the role of BRP-39 in profibrotic responses after AKI.

236 a critical role of TAZ/YAP in mediating the profibrotic responses in dermal fibroblasts.

237 ork reveals a role for csGRP78 in HG-induced profibrotic responses in mesangial cells, informing a po

238 R2, TLR4, or the coreceptor CD14 reduced the profibrotic responses of uremic leukocytes to endogenous

239 etabolic health may also attenuate long-term profibrotic responses that could lead to chronic kidney

240 To better understand these profibrotic responses, we performed mass spectrometry on

241 nhibited PDE-induced, TLR2- or TLR4-mediated profibrotic responses.

242 initiating and perpetuating inflammatory and profibrotic responses.

243 t its up-regulation may augment high glucose profibrotic responses.

244 of CAM s could also inhibit AAM s and their profibrotic responses.

245 ic overexpression of ATX established a liver profibrotic role for ATX/LPA, whereas pharmacological AT

246 has been tempered by concerns of a possible profibrotic role of endogenous MSCs in response to injur

247 Altogether our findings support a profibrotic role of PDGFR-alpha in HSCs during chronic l

248 Epigenetic mechanisms for persistence of the profibrotic RVfib phenotype in culture were evaluated.

249 t, unregulated, and progressively increasing profibrotic signaling along multiple pathways.

250 renal fibrogenesis by activation of multiple profibrotic signaling and transcription factors, and sup

251 Biomarkers associated with profibrotic signaling are altered in HF with reduced eje

252 Recent research suggests that profibrotic signaling by transforming growth factor beta

253 tein CCN1 enhances TGF-beta1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to

254 dicate that the KLHL42-PPP2R5e axis controls profibrotic signaling in SSc lung fibroblasts.

255 chemical inhibition of KLHL42 may ameliorate profibrotic signaling in SSc.

256 or of macrophage-myofibroblast crosstalk and profibrotic signaling in the setting of maladaptive kidn

257 Thus, cardiac hypertrophy is uncoupled from profibrotic signaling in this mouse model, which we tie

258 , Twist, and Notch1; and inactivated several profibrotic signaling molecules in the injured kidney, i

259 n complex 1 (mTORC1) activation, another key profibrotic signaling pathway.

260 nd EMT by suppressing activation of multiple profibrotic signaling pathways while retaining expressio

261 play antagonistic roles in the modulation of profibrotic signaling through opposite effects on MAN1 l

262 functional connective tissues with excessive profibrotic signaling, affecting skin, cardiovascular, a

263 n, apoptosis, inflammatory cell recruitment, profibrotic signaling, and altered progenitor function t

264 2R5e knockdown exacerbated TGF-beta-mediated profibrotic signaling, indicating a role of PPP2R5e in S

265 suggest that sacubitril/valsartan may reduce profibrotic signaling, which may contribute to the impro

266 y should lead to mechanistic studies on TSLP profibrotic signaling.

267 otein 42 (KLHL42) impairs TGF-beta-dependent profibrotic signaling.

268 uggests dual glaucomatous insults potentiate profibrotic signaling/phenotypes.

269 on of RhoA, which is known to be involved in profibrotic signalling pathways.

270 mediate tissue inflammation, cell death and profibrotic signalling.

271 STAT3 thus integrates several profibrotic signals and might be a core mediator of fibr

272 Here we show that profibrotic signals converge on STAT3 and that STAT3 may

273 stellate cells (HSCs), and amplification of profibrotic signals.

274 iopsies reveals a strong proinflammatory and profibrotic signature in the hearts of nonresponders com

275 These activated fibroblasts exhibit a clear profibrotic signature, express high levels of Cthrc1 (co

276 elial-to-mesenchymal transition (EMT) to the profibrotic stiff microenvironment and myofibroblast acc

277 ion and inhibition on fibroblast response to profibrotic stimuli were analyzed in vitro in primary hu

278 reduced the responsiveness of fibroblasts to profibrotic stimuli, including significant reductions in

279 ntinuous administration of angiotensin II, a profibrotic stimulus that drives pathological cardiac re

280 MiR-214(-/-) prevented Ang II-induction of profibrotic T cell cytokines (IL-17, TNF-alpha, IL-9, an

281 ormal lung fibroblasts and the expression of profibrotic targets, cell migration, and soft agar colon

282 pSMAD3 using the TAT-SNX9 peptide inhibited profibrotic TGF-beta activity in murine cells and human

283 cription factors, the canonical mediators of profibrotic TGF-beta responses.

284 tives on the interrelation of metabolism and profibrotic TGF-beta signaling and present opportunities

285 HK2 can be integrated within the context of profibrotic TGF-beta signaling.

286 lities, fractionated electrograms, increased profibrotic TGF-beta1 expression, interstitial atrial fi

287 asts into myofibroblasts via suppressing the profibrotic TGF-beta1 signaling.

288 hways, including ERK and AKT, as well as the profibrotic TGF-beta1/SMAD pathway.

289 addition to an endogenous role for PD-L1 in profibrotic TGFbeta signaling, TGFbeta stimulated-human

290 d with increased promoter methylation of the profibrotic TGFbeta transcription factor SMAD3 compared

291 llowing MI may separately regulate different profibrotic traits of activated CFBs.

292 tent imaging of nuclear translocation of the profibrotic transcription factor SMAD family member 2/3

293 hannel subfamily C member 6 (TRPC6), and the profibrotic transcription factor, Yes-associated protein

294 ork analysis prioritized proinflammatory and profibrotic transcription factors such as Irf1, Nfkb1, a

295 P1) is activated by tissue stiffness and the profibrotic transforming growth factor-beta1, but its ro

296 Profibrotic up-regulation of glucose transporter 1 by TG

297 r a week, the cardiac environment changed to profibrotic with growth factor and TH2-interleukin synth

298 The AHR and AHR ligands block profibrotic Wnt signaling by inhibiting the phosphorylat

299 3, indicating that Klotho inhibition of the profibrotic Wnt/TGFbeta axis underlies its anti-fibrotic

300 clusters were enriched with cells expressing profibrotic YAP1 target genes, ACTA2, ELN, and COL1A1, i