ライフサイエンスコーパス: profiling

1 noprecipitation sequencing and transcriptome profiling.

2 , (13)C NMR followed by (1)H-NMR metabolomic profiling.

3 stone marks but is not optimized for H3K27ac profiling.

4 ations and can be informed by careful immune profiling.

5 ing, copy-number arrays, and gene expression profiling.

6 richment of rare cell types by droplet-based profiling.

7 rm chromatin, transcriptomic and interaction profiling.

8 hnology to enable saturated domain insertion profiling.

9 ent and accurate alignment-based metagenomic profiling.

10 tomic single-cell atlases with protein-level profiling.

11 ll biology, pathogenicity and transcriptomic profiling.

12 nables intracellular deubiquitinating enzyme profiling.

13 rts are propelled by advances in single cell profiling.

14 molecule through single-cell gene expression profiling.

15 100 Wellness Project involved quantitatively profiling 108 participants' molecular physiology over ti

16 with melanoma showed via targeted expression profiling(17) that B cell signatures were enriched in th

17 0 samples representing 15 organs, ultimately profiling ~4 million single cells.

18 genomic resource for mammalian development, profiling a diverse panel of mouse tissues at 8 developm

19 porter cell lines and activity-based protein profiling (ABPP) chemical proteomics to identify the pro

20 ms and cleavage outcomes requires systematic profiling across mispaired target DNAs.

21 HogProf enables large-scale phylogenetic profiling across the three domains of life, and will be

22 based on its promising selectivity following profiling against 260 human kinases.

23 n in hepatocytes, followed by RNA-sequencing profiling, allowed the identification of a "Myc/beta-cat

24 The gene expression profiling analysis showed that PRLT2/89-33 has an inhere

25 munoprecipitation system (LIPS) for antibody profiling and a panel of conserved EEHV recombinant prot

26 Here, using single-cell gene expression profiling and anatomical circuit analyses of vermis outp

27 Chemogenetic manipulations, translational profiling and anterograde tracing identify a subset of d

28 asthma and controls for nasal transcriptome profiling and applied network-based and probabilistic ca

29 itates robust clinical evaluation, biomarker profiling and assessment of comorbid factors to identify

30 Using complexome profiling and biochemical analyses, we have explored the

31 : relatively susceptible) using metabolomics profiling and cell wall sugar characterization at differ

32 hese advances should not only facilitate the profiling and characterization of amyloids for structura

33 Gene profiling and ChIP-Seq analysis identified Klk1b21 as an

34 ell RNA-sequencing, ribosome-associated mRNA profiling and chromatin analyses, combined with electrop

35 re the discrimination efficiency of targeted profiling and fingerprinting approaches.

36 y (UHPLC-HRMS) method for salivary metabolic profiling and fingerprinting.

37 ested for immune phenotyping, transcriptomic profiling and functional assays.

38 Using scRNA-seq profiling and genetic lineage tracing, we show that RUNX

39 Using deep variant profiling and GPCR assays in HEK293 cells, we assessed t

40 In summary, using a combination of metabolic profiling and GWAS, we identified FADS3 to be essential

41 s the first report of longitudinal metabolic profiling and identification of unique biomarkers of FXT

42 chanistic characterization through viral RNA profiling and in vitro MeV polymerase assays identified

43 ence-based assays, and by analyzing ribosome-profiling and mass spectrometry (MS) data.

44 of DNA detection methods including microbial profiling and may advance the utility of dPCR in clinica

45 Biological profiling and mutant analysis revealed that this compoun

46 ents, assembly, extensive pruning, taxonomic profiling and reference sequence databases.

47 keratinocytes were evaluated with microarray profiling and reverse transcriptase-PCR.

48 nship may exist between gut dysbiosis, miRNA profiling and SCFA level in response to intestinal infla

49 important tool for high-throughput N-glycan profiling and, upon use of tandem MS, for structure dete

50 mbination of in vitro biochemistry, ribosome profiling, and cryo-EM to define molecular mechanisms th

51 combination of multiscale modeling, ribosome profiling, and gene ontology analyses.

52 nation of cryo-electron microscopy, ribosome profiling, and mRNA stability assays to examine the recr

53 ss-linking and isolation by pull-down target profiling, and to rescue disease-relevant splicing of ta

54 r for the fingerprinting (100%) than for the profiling approach (45.5-100%).

55 omic developments, we hope this inflammation-profiling approach will enable further discoveries that

56 High-resolution tracking and profiling approaches have accelerated these efforts, rev

57 Here, by unbiased genomic profiling approaches, we identify the direct target site

58 ogical, cell biological, and gene expression profiling approaches, we report here multiple lines of e

59 L. scoparium nectar, thus presenting peptide profiling as a viable and novel approach for manuka hone

60 ell wall composition was analysed by glycome profiling assay.

61 To devise an economical set of phenomic profiling assays, we assembled a library of 1,008 approv

62 Here, we perform deep transcriptomic profiling at high temporal resolution as macrophages are

63 We used metabolite profiling before and after acute exercise to delineate t

64 All DMB/MBEN assessed by DNA methylation profiling belonged to the SHH-INF subgroup.

65 ondrial apoptotic priming as measured by BH3 profiling, both in PDX models and human clinical samples

66 Profiling by BH3 mimetics was performed in CLL cells ful

67 Spatially-resolved molecular profiling by immunostaining tissue sections is a key fea

68 Global profiling by mass spectrometry showed that placental EVs

69 Furthermore, gene expression profiling by next-generation sequencing alone, or in com

70 Here, we present prokaryotic expression profiling by tagging RNA in situ and sequencing (PETRI-s

71 Culture-enriched molecular profiling can be used to better understand the role of t

72 -CM), a microfluidic technology that enables profiling cell samples that individually do not generate

73 This versatile method for profiling cell surfaces has the potential to advance und

74 discuss applications of these techniques in profiling cells and circuits in mice.

75 e common diseases, a comprehensive molecular profiling characterizing and differentiating the 2 disea

76 MtDNA-microsatellite profiling combined with relatedness and network analysis

77 metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota composition

78 -specific ribosome dwell times from ribosome profiling, considering codon pair interactions between r

79 Here we examined whether molecular profiling could be used to identify functional clusters

80 Transcriptional profiling coupled with T cell receptor (TCR) sequencing

81 Profiling ctDNA almost invariably requires prior knowled

82 Ribosome profiling data revealed that ORF-Y is translated and tha

83 le to produce a "one-size-fits-all" ribosome profiling data set.

84 ults on artificial single-cell transcription profiling data show that the proposed procedure successf

85 r subtypes through the use of transcriptomic profiling data.

86 the chromatin level, utilization of ATAC-Seq profiling demonstrated a dramatic remodeling of DNA acce

87 Ribosome profiling demonstrated Ebp1-60S binding is highest durin

88 Single-cell profiling demonstrated no adverse perturbation of retina

89 DNA and cDNA 16S rRNA gene profiling demonstrated that the microbial community was

90 roach using Argonaute eCLIP-seq and ribosome profiling, demonstrating that CARP defines a comprehensi

91 RNA-seq tape strip profiling detected distinct immune and barrier signature

92 Transcriptome profiling displayed that TGF-beta pathway activation and

93 NanoString Digital Spatial Profiling (DSP) allows for spatially resolved, highly mu

94 Digital Spatial Profiling (DSP) is a method for highly multiplex spatial

95 Genome-wide profiling during reprogramming reveals CoREST represses

96 Comprehensive genomic profiling enables genomic biomarker detection in advance

97 Gene expression profiling experiments have shown induction of responses

98 imate Experiment (GRACE) satellites and Argo profiling floats, it has been possible to measure the re

99 evelopment, biomarker detection, and protein profiling for diagnostic applications.

100 aracterization of tumors, multigenetic tumor profiling for targeted therapeutic selection remains lim

101 In the context of mRNA biomarker profiling, formalin fixed paraffin embedded (FFPE) sampl

102 xteen tape strips were collected for RNA-seq profiling from 19 infants/toddlers (<5 years old; lesion

103 The results were compared with hippocampal profiling from other bred rat models.

104 e describe a direct infusion strategy for CL profiling from total lipid extracts utilizing gas-phase

105 Transcriptional profiling, functional assays, and acute in vivo myeloid-

106 on (ChIP) is the most important approach for profiling genome-wide epigenetic changes such as histone

107 ckness on prognostication by gene expression profiling (GEP) class.

108 Competitive cysteine profiling has been performed to interrogate itaconate's

109 Phylogenetic profiling has customarily been more widely used with pro

110 or metastatic disease, comprehensive genomic profiling has revealed several potentially actionable al

111 Ribosomal profiling has shed new light on how ribosomes can ignore

112 Molecular profiling has the potential to be more precise and objec

113 As two-arm studies with gene expression profiling have been rarer than similar one-arm studies,

114 ned by one of the following: gene expression profiling high risk (GEP(hi)), t(14;16), t(14;20), del(1

115 NA translation; ranging from codon occupancy profiling, identification of actively translated open re

116 RNA sequencing profiling identified integrin-linked kinase (ILK) as the

117 Methylome and transcriptome profiling identified several inflammatory responses and

118 Transcriptional and chromatin profiling identifies how cell states and gene-regulatory

119 By a combination of metabolic profiling, imaging mass spectrometry, structure elucidat

120 of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for

121 Here, we developed ribosome profiling in a model archaeon, Haloferax volcanii, eluci

122 Unbiased transcriptional profiling in an adult-onset Pkd2 mouse model before cyst

123 In this study, we performed metabolite profiling in both brain (n = 109) and matching serum sam

124 eed for spatially resolved protease activity profiling in cancer, we developed a new class of in situ

125 ally resolved in situ cell-surface proteomic profiling in discovering regulators of brain wiring.

126 asive alternative, but global transcriptomic profiling in early pediatric AD is lacking.

127 ion and knockdown approaches, and plasma LCB profiling in FADS3-deficient mice confirmed that FADS3 i

128 Here we used ribosome profiling in melanoma cells to investigate the effects o

129 In addition, we used N-terminomic proteomic profiling in preclinical models to elucidate the in vivo

130 nfluence on primary and secondary metabolite profiling in skin + pulp/flesh and seeds were also deter

131 Unbiased mRNA expression profiling in the medial PFC (mPFC) of maternally separat

132 and discuss the additive value of molecular profiling in the setting of diagnosing renal allograft r

133 Using high-resolution single-cell profiling in tissue, we have uncovered the diverse lands

134 ome a state-of-art approach to heterogeneity profiling in tumor cells.

135 e, we performed disome and trisome footprint profiling in yeast and found collisions were enriched on

136 We show application of STRIPE-seq to TSS profiling in yeast and human cells and show that it can

137 ogy of relapse through comprehensive genomic profiling, incorporation of molecularly targeted therapi

138 ace phenotype and NanoString gene expression profiling indicated the closest steady-state counterpart

139 -specific metabolites as well as obtain full profiling information.

140 t single-cell resolution: RAISIN RNA-seq for profiling intact nuclei with ribosome-bound mRNA and MIR

141 Image-based profiling is a maturing strategy by which the rich infor

142 A population of interest for metabolome profiling is patients with rare disease for which abnorm

143 Gas chromatography-mass spectrometry profiling is the most established method for the analysi

144 ed quantitative mass spectrometry metabolite profiling is the workhorse of metabolomics research.

145 overview on compound classes (phytochemical profiling) is needed before single-substance considerati

146 explore this relationship by epigenetically profiling joint chondrocytes, revealing ancient selectio

147 Here endocrine profiling, longitudinal observations of known individual

148 Single-cell molecular profiling methods allow the exploration of neural divers

149 to comprehensive phenotyping, transcriptome profiling, molecular pathway identification, and validat

150 that we refer to as mutant thermal proteome profiling (mTPP).

151 ly proposed tumor fitness measures, based on profiling neoepitopes for reactive viral epitope similar

152 e, we performed genome-wide miRNA expression profiling of 124 fresh, paired colorectal tumor and nont

153 Targeted gene expression (GE) profiling of 184 genes using nCounter technology was per

154 Here, we show transcriptome profiling of 21,422 single cells-including cardiomyocyte

155 Deep serological profiling of 232 coronavirus disease 2019 (COVID-19) pat

156 CITE-seq profiling of 82 surface proteins and transcriptomes of 5

157 A hypothesis-free profiling of ACE2 suggests tongue keratinocytes, olfacto

158 ctroscopy was used for unambiguous metabolic profiling of albedo, flavedo and juice samples.

159 The profiling of bacterial communities by the sequencing of

160 creens combined with comprehensive molecular profiling of BBDI response and resistance, we identified

161 A combination of molecular and functional profiling of bone marrow and peritoneal cells provided a

162 Phenotypic and transcriptomic profiling of c-Maf-deficient CCR6(-) ILC3s revealed a hy

163 spectrometry-based metabolomic and proteomic profiling of cancer cells cocultured with primary human

164 We argue that the integration of molecular profiling of cancerous tissues with deep, longitudinal p

165 Here, we used RNA-profiling of canine mammary tumors (CMTs) coupled with a

166 We analyzed matched time course RNAseq profiling of cells treated with single drugs and their c

167 This enables routine genome-wide profiling of chromatin proteins and modifications and re

168 Transcriptomic profiling of cortical neural progenitor cells derived fr

169 Serial profiling of ctDNA in a subset correlated with treatment

170 Our analyses provide the first genome-wide profiling of DNA hydroxymethylation of the frontal corte

171 ncing as a diagnostic tool is leading to the profiling of drug resistance to inform clinical practice

172 aches are warranted for comprehensive safety profiling of ECIG.

173 tive latent probe (HFOLP), for the selective profiling of endogenous formaldehyde.

174 Global N-acetylome profiling of Escherichia coli cells expressing AtNAA50 r

175 Proteomic and RNA profiling of EVs identifies diverse RBPs and small non-c

176 Metabolomic profiling of fasting serum was performed using a global,

177 integrative network analysis of multi-omics profiling of four cortical areas across 364 donors with

178 Transcriptional profiling of HSPCs from mTOR(ECKO) mice revealed that th

179 Furthermore, we compared profiling of human HSC microRNAs with that of rat HSC so

180 Our combined transcriptional profiling of human myenteric ganglia and mouse EN provid

181 has enabled the simultaneous transcriptomic profiling of individual cells under different biological

182 zation, mapping of subsite interactions, and profiling of inhibitor selectivity.

183 er intravenous cocaine, we did transcriptome profiling of LH MCH neurons after long-term withdrawal u

184 ithin FA isomers and often limited to global profiling of lipids without spatial resolution.

185 sitivity, robust, and reproducible proteomic profiling of low nanogram-level complex biological sampl

186 Echocardiographic-derived profiling of LV forward flow, filling pressure, and RV f

187 Lastly, profiling of miRs from CAF exosomes showed alterations o

188 ed with intact protein mass spectrometry for profiling of mispairing and other product-related impuri

189 Technological advances have enabled the profiling of multiple molecular layers at single-cell re

190 We present a comprehensive miRNA profiling of naive-to-primed transition in hPSC, a proce

191 Transcriptional profiling of oxidative stress-producing CNS innate immun

192 We performed longitudinal multi-omic profiling of plasma and peripheral blood mononuclear cel

193 eq, a method for multiplexed transcriptional profiling of post-perturbation responses across a mixtur

194 on of FXTAS, we performed global metabolomic profiling of premutation carriers (PM) who, as part of a

195 Proteomic and phosphoproteomic profiling of primary tumors alone successfully distingui

196 SP) is a method for highly multiplex spatial profiling of proteins or RNAs suitable for use on formal

197 Profiling of rRNA operons using the Oxford MinION yielde

198 d an experimental pipeline for comprehensive profiling of small exRNAs isolated from cell culture.

199 Due to challenges in accurate profiling of small RNAs, a vast majority of public trans

200 Here we report the genomic profiling of solid tumors from 131,668 cancer patients,

201 trait loci, elucidated by direct epigenetic profiling of specific human tissues, may contribute towa

202 k screening as a novel platform enabling the profiling of subcellular phenotypes associated with pert

203 High-dimensional single-cell profiling of T cells from chemotherapy-naive individuals

204 id tissues (GALTs) that allows unprecedented profiling of the adaptive immune system in submucosal an

205 Here, gene expression profiling of the bone marrow along disease progression i

206 Profiling of the glycans and the glycolipids is performe

207 Using genome-wide profiling of the H3K27ac histone modification, we identi

208 Using RNA-seq profiling of the intima of lesions, here we identify a m

209 Gene expression profiling of the isolated cell protrusions suggested tha

210 of cancerous tissues with deep, longitudinal profiling of the physiological state of an individual ('

211 Profiling of these 300 strains, using parallel (DCyFIRsc

212 arding microglial activation and an in-depth profiling of those cells in MDD is lacking.

213 Profiling of TL and LS bladder afferents was also perfor

214 Profiling of ~82,000 single peripheral blood mononuclear

215 We perform DNA copy number profiling on mixtures of cell lines, nuclei from frozen

216 l parameters, gene expression and metabolite profiling on plants grown under glasshouse or polytunnel

217 Based on MFC profiling, patients with MDS-PA have altered hematopoies

218 rium tuberculosis bacilli to develop a rapid profiling platform called Morphological Evaluation and U

219 Using a digital spatial profiling platform, we find the virus corresponds to dis

220 Metagenomic profiling, predicting the presence and relative abundanc

221 eomics, the autosampler was first applied to profiling protein expression in single MCF10A cells usin

222 Specifically, we developed the profiling protocol for tumor-normal matched tissue sampl

223 Single cell and single nucleus RNA profiling provide one avenue to decipher this heterogene

224 Overall, KinCon profiling provides additional mechanistic insights into

225 Progress in high-throughput metabolic profiling provides unprecedented opportunities to obtain

226 ution mass spectrometry (HRMS) combined with profiling qualitative metabolomics for the analysis of t

227 tide-level matching strategy, our DeltaSILAC profiling revealed a global, unexpected delaying effect

228 Genome-wide copy number profiling revealed a high degree of similarity between B

229 Lipid profiling revealed ala4/5 rosettes had perturbations in

230 Immune profiling revealed an overall increase in innate cell li

231 Ribosome profiling revealed an uncharacterized complexity of tran

232 scriptomic, proteomic, and phospho-proteomic profiling revealed enrichment of Hippo/YAP and c-MYC sig

233 Moreover, global metabolic profiling revealed extensive alterations in the cellular

234 Polygenic risk score profiling revealed improved prediction based on trans-an

235 derived from human ER+ MCF7 cells, molecular profiling revealed increased PREX1 expression in a cell

236 only serum Mn, and plasma protein N-glycome profiling revealed reduced complexity and branching.

237 Immune profiling revealed reductions and rapid recovery in lymp

238 Genomic profiling revealed some of the mechanisms that drive evo

239 CyTOF profiling revealed that AXL inhibition suppressed SMAD4/

240 Immunoproteomics profiling revealed that BPZE1 elicited broader and diffe

241 In MIM159 tobacco, transcriptome profiling revealed that genes associated with defense an

242 Global transcriptome profiling revealed that TamS cells adapt to OSMI-1 treat

243 Metabolomic profiling revealed that the maternal microbiome regulate

244 Further profiling revealed that these innate, public Vgamma9Vdel

245 Lipidomic profiling reveals that SNX14 (KO) cells increase membran

246 Ribosome profiling (Ribo-seq) is a powerful technology for global

247 Here, by ribosome profiling (Ribo-seq) we find specific dysregulation of e

248 Molecular profiling (RNA sequencing) was used to identify enriched

249 We have adapted ribosome profiling (RP) workflows from the Illumina to the Ion Pr

250 ound (VOCs) fingerprint and by panel sensory profiling (SENS).

251 sing transcriptome-wide RNA-Seq and polysome profiling-Seq in halofuginone-treated fibroblasts, we id

252 boFlow pipeline that processes raw ribosomal profiling sequencing data.

253 ontrol study by analyzing 16S rRNA microbial profiling, shotgun metagenomics and SCFAs in 153 fecal s

254 MicroRNA and RNA profiling show that this variant disrupts precursor micr

255 Micro-nutrient profiling showed Ca, Fe, Zn, P, K and Mn in the range of

256 In these cases, gene expression profiling showed diminished expression of genes required

257 Amino acid profiling showed good amount of essential amino acids.

258 Consistent with these results, transcriptome profiling showed increased expression of several direct

259 n JAGGED1 and cell survival, transcriptional profiling showed that JAGGED1 maintains genes critical f

260 RNA-Seq profiling shows differential expression of many transcri

261 e developed serial NEDD8-ubiquitin substrate profiling (sNUSP), a method that employs NEDD8 R74K knoc

262 nsporter inhibition assays in the early ADME profiling space in drug discovery.

263 ulticolor flow cytometry and transcriptional profiling successfully predict the bipotent phenotype of

264 RNA profiling suggested that treatment benefit did not depen

265 Moreover, transcriptional and phenotypic profiling suggests that MCD/C5s, as a class, represent b

266 ower of dHRM technology for defined sequence profiling tasks.

267 of studies focusing on miRNA discovery using profiling techniques and bioinformatic modeling of the n

268 Recent advances in protein profiling technology has facilitated simultaneous measur

269 Profiling the heterogeneous phenotypes of live cancer ce

270 However, relatively scarce data on profiling the inflammatory responses in pediatric TB are

271 Profiling the noncoding genome provides new insights int

272 engineering, isotope labeling and metabolic profiling to capture PFCs and demonstrate their function

273 scheme, several groups have used single-cell profiling to catalog DA neurons based on their gene expr

274 n sequencing and array-based DNA methylation profiling to determine the clinically actionable genomic

275 ribosome affinity purification and ribosome profiling to identify biologically relevant prion-induce

276 et al. used longitudinal and deep multi-omic profiling to identify individuals with distinct BA pheno

277 Future studies should include omics profiling to investigate sex-associated molecular differ

278 uman proteome, and apply protein correlation profiling to map IFN-induced rearrangements in the human

279 We use genomic profiling to reveal strong and broad loss of neural APA

280 We applied MS-based thermal proteome profiling (TPP) to investigate the proteome-wide effects

281 We addressed this challenge by profiling transcriptional, translational, and posttransl

282 Further transcriptional profiling uncovered unique upregulation of the inhibitor

283 DNA methylation and chromatin accessibility profiling uncovering epigenetic reprogramming at >1400 s

284 ents, we performed comprehensive serological profiling using a high-throughput phage immunoprecipitat

285 onjunction with transcriptomic and proteomic profiling using fly heads.

286 ion sequencing technologies, gene expression profiling using RNA-seq has increased the scope of seque

287 RNA was analysed by microarray gene profiling using the Illumina HumanHT-12 v 4 Expression B

288 , respectively, while gliadins and glutenins profiling was done by SDS-PAGE.

289 RNA-seq profiling was done on leaf samples collected at 0, 1, 3,

290 Comprehensive miRNA profiling was performed on plasma-derived exosomes.

291 ultured islets was purified and global miRNA profiling was performed with 3D-Gene global miRNA microa

292 Transcriptional profiling was performed with Affymetrix arrays, Principa

293 Molecular profiling was successful in 93.0% of specimens.

294 ng single-cell RNA sequencing and epigenetic profiling, we demonstrate that R-VECs establish an adapt

295 in vitro and in vivo RNA chemical structure profiling, we determine that hundreds of RNA G-quadruple

296 RISPR screens and single-cell RNA-sequencing profiling, we have uncovered transcriptional regulators

297 Using unbiased kinase profiling, we identified protein kinase A (PKA) as an ac

298 AGELLAN is attributed to the power of ligand profiling, which integrates complementary methods for li

299 Comprehensive immune profiling will allow us to better understand how to mini

300 By coupling in vivo ribosome profiling with genetic screening, we provide direct evid