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1 and socio-economic changes will affect them profoundly.
2 t ecosystems, human health and biotechnology profoundly.
3 stretching region is a manifestation of how profoundly a water molecule is distorted when embedded i
7 onstrate that Xenopus deltabetagamma-ENaC is profoundly activated by extracellular acidification with
9 us of intensive molecular profiling efforts, profoundly advancing our understanding of biologically a
12 ant of a tumor's microenvironment (TME), and profoundly affect drug delivery, therapeutic efficacy an
13 paration is artificial since Ca(2+) dynamics profoundly affect ion channels and electrogenic transpor
14 Such changes in cellular ribostasis could profoundly affect neural development and contribute to t
15 re explore the effect of blanching which can profoundly affect protein composition and introduce prot
17 Thus, the details of single-RyR gating can profoundly affect SR Ca(2+) release even if open probabi
20 r alkylating chemicals have the potential to profoundly affect the chemical properties and hence the
21 esses from post-monsoon to winter transition profoundly affect the composition of the fine aerosols o
22 der two aspects of the human enterprise that profoundly affect the global environment: population and
24 ample where the impact of lifestyle seems to profoundly affect the P450 profiles in the bacterial spe
28 heterogeneous electrocatalytic processes is profoundly affected by the liquid side of the electrocat
29 e OH stretching vibrations under pressure is profoundly affected by the presence of the guest fluid,
31 it expression of GABA(A)R populations, which profoundly affected receptor function and synaptic inhib
33 electric lighting over the past century has profoundly affected the circadian organization of physio
35 stribution between the polymeric phases that profoundly affected the structural properties of the pre
37 organization of genomic DNA into nucleosomes profoundly affects all DNA-related processes in eukaryot
38 ibular joint (TMJ) disc nutrient environment profoundly affects cell energy metabolism, proliferation
39 The length of nucleosome free regions (NFRs) profoundly affects clutch size, while the length of link
42 cally alters brain cytoskeletal dynamics and profoundly affects neuronal proteostasis and plasticity.
44 The presence of large perinuclear aggregates profoundly affects the behavior and health of the cell,
45 ciently small thickness, the sample geometry profoundly affects the dynamics by modifying the spectra
47 ns suggest that targeting REV1 with JH-RE-06 profoundly affects the nature of the persistent genomic
48 ) channel with auxiliary BK-beta1-4 subunits profoundly affects the regulatory mechanisms and physiol
49 icular FA profiles through advanced breeding profoundly affects WFT behavior in ways that benefit man
53 ects, despite being spatially localized, can profoundly alter global properties such as the crystal s
54 hat naturally occurring genetic variants can profoundly alter normal protein function, impacting phys
55 s like lysophosphatidylcholine or oleic acid profoundly alter pore expansion and fully rescue the dec
57 DSCAM as well as the DSCAML1 ICDs alone can profoundly alter the expression of genes associated with
58 ial of severe environmental perturbations to profoundly alter the macroevolutionary dynamics of anima
59 screened even in the metallic regions, which profoundly alter the quantum Hall state by forming edge
60 their positioning within the active zone can profoundly alter the timing and strength of synaptic out
61 and downstream mechanosensitive signaling to profoundly alter the tumor microenvironment, which appea
63 Further, simply harboring the HIV genome profoundly altered astrocyte biology, resulting in a pro
65 The catalytic sites of acidic zeolite are profoundly altered by the presence of water changing the
66 differential effect on clot structure and G2 profoundly altered fibrin fiber arrangement, whereas F5
68 uman Papilloma Virus (HPV) that manifests as profoundly altered phonatory and upper respiratory anato
69 es in B and myelomonocytic cell composition, profoundly altered T cell phenotypes, selective cytokine
70 capacity to form biological condensates has profoundly altered the concepts about the pathogenesis o
71 his caused enhanced nuclear translocation, a profoundly altered transcriptional program, and increase
72 marrow immune environment of AML patients is profoundly altered, contributing to the severity of the
74 ology, and function of synaptic contacts are profoundly altered, resulting in abnormal connectivity a
75 ive global enhancer gain/loss reprogramming, profoundly altering breast cancer transcriptional progra
76 metamorphosis, holometaboly, and occurred by profoundly altering embryogenesis to produce a larval st
77 ne heatwaves are causing coral bleaching and profoundly altering habitat structure, yet despite sever
78 r data suggest that harboring the HIV genome profoundly alters astrocyte biology and that strategies
79 lts demonstrate that local genetic diversity profoundly alters meiotic repair pathway decisions via a
80 s and myelin sheaths in cortical gray matter profoundly alters neural activity and is associated with
81 scriptionally active in airways, nuclear Yap profoundly alters proximal-distal identity and halts epi
82 l whether respiratory mucosal TB vaccination profoundly alters the airway innate immune landscape ass
83 an intrinsic voltage-gated conductance that profoundly alters the integrative properties and visual
84 show that intravenous administration of BCG profoundly alters the protective outcome of Mtb challeng
85 ysiological relevance, we show that m6A loss profoundly alters these cues and perturbs cellular fate
88 tinctive DMN activity patterns that are more profoundly associated with either normal ageing or a str
92 ate for de novo nucleotide synthesis differs profoundly between cancer cell lines and fresh human lun
94 d show that accounting for these effects can profoundly change our understanding of how microbes infl
95 gic therapies or novel small molecules could profoundly change the natural history of the disease and
96 tures, rationalize mechanistic behavior, and profoundly change the way chemists discover and optimize
97 navirus disease-2019 (COVID-19) pandemic has profoundly changed clinical care and research, including
98 oups of fish benefiting from marine reserves profoundly changed, with low trophic level herbivores do
99 vertebrate centrosome/cilium complex, which profoundly changes the way we think about the assembly,
101 lities (e.g., gene and immune therapies) are profoundly changing the oncology landscape, bringing wit
102 ts how they are advancing, and in some cases profoundly changing, our understanding of energy, water,
103 es conceptual and experimental strategies to profoundly characterize epistasis in a protein, relevant
106 urbation of epidermal barrier formation will profoundly compromise overall skin function, leading to
108 y and the distal epigenetic landscape, which profoundly contributed to VEGFA-dependent changes in gen
109 data suggest that ETC activity in mammals is profoundly controlled by mtFAS function, thereby connect
110 ition of P. gracilior leaves, ensuring their profoundly correlation with the molecular expression of
112 lls, and their extensive circuit innervation profoundly dampens circuit excitability under normal con
115 By 30 d, Tmc1 pD569N heterozygote mice were profoundly deaf, and there was substantial loss of outer
118 nts, the iron-regulatory hormone hepcidin is profoundly decreased in pregnant mothers, which is thoug
120 mammalian hippocampal development, which is profoundly defective upon loss of either Lhx2 or Ldb1 El
122 Specifically, mac1Delta/Delta mutants are profoundly deficient in mitochondrial respiration and Fe
123 inical management in response to viremia was profoundly delayed, prolonging the duration of viremia a
127 find that these different 'brain types' had profoundly different cognitive abilities with higher per
129 pression distinguishes MBC subsets that have profoundly different homing, residency, and functional p
131 ssion resultant from dynamic crowding can be profoundly different than that of steady-state crowding.
132 rmations, caused ectopic pioneer activities, profoundly diminishing GATA4, FOXA1/2, and PDX1 expressi
133 ed deletion of Ireb2 in a mouse model causes profoundly disordered iron metabolism, leading to functi
138 outline a critical one-two punch injury that profoundly disrupts immune tolerance in this devastating
140 undamental to primary hemostasis, but become profoundly dysfunctional in critically injured patients
143 lemman phosphorylation in the PLM(3SA) mouse profoundly enhanced vascular responses to phenylephrine
145 Marker-gene and metagenomic sequencing have profoundly expanded our ability to measure biological co
146 eatures a highly polarized CT state having a profoundly extended (3)MLCT lifetime (160 ps), (3)MLCT p
147 ffects seen for singly charged metals differ profoundly from binding of multiply charged ions, often
151 (CIs) have enabled hundreds of thousands of profoundly hearing-impaired people to perceive sounds by
153 Here, we explore the hypothesis that this profoundly immunoinhibitory signaling environment depriv
154 f CAR T cells when encountering antigen in a profoundly immunosuppressive tumor microenvironment.
158 roperty of the ECM and cytoskeletal tension, profoundly impact on autophagic flux in a YAP/TAZ-mediat
159 on in cerebral oxygenation, which appears to profoundly impact on the maturation of cerebral regions
160 roorganisms and nematodes in the rhizosphere profoundly impact plant health, and small-molecule signa
161 n showed that the stimulation conditions can profoundly impact the activation readout in unexposed in
162 s sinkholes in SD fitness landscapes and may profoundly impact the evolution and function of prokaryo
163 s (TEs) are mobile genetic elements that can profoundly impact the evolution of genomes and species.
165 f solute atoms at grain boundaries (GBs) can profoundly impact the structural properties of metallic
166 pical oligotrophic microbes, and potentially profoundly impact the trophic status of temperate waters
167 hese tumour-derived circulating factors also profoundly impact tissues that are rarely inhabited by m
170 1690 suppressed AKT and ERK1/2 signaling and profoundly impacted the transcriptome of these cells whi
171 dynamic phase of postnatal neuroplasticity, profoundly impacted transcription in each neuron subtype
172 urbance, particularly REM sleep disturbance, profoundly impacts emotion regulation, but the underlyin
175 to the Fc whose presence and fine structure profoundly impacts on their in vivo immunogenicity, phar
176 Here we report that RGS14 encoding LR or RQ profoundly impacts protein functions in hippocampal neur
178 development: haploinsufficient B cells were profoundly impaired in responses to antigen in vivo.
181 hat spinothalamic ablation in humans, whilst profoundly impairing pain, temperature and itch, had no
182 ICANCE STATEMENT Repeated exposure to stress profoundly impairs cognitive functions like memory, atte
183 t optogenetic disruption of this MN activity profoundly impairs safety learning, abnormally slowing d
184 the localization of DNMT1 in stem cells and profoundly impairs the global DNA methylation and genomi
185 ression in the tumor microenvironment, which profoundly impedes the clinical response to immune-depen
187 iven that Ca(2+) homeostasis in microglia is profoundly important to its function, this computational
188 s the first to show that BR therapy leads to profoundly improved stroke outcomes in mice and that the
190 king activity and reduced visual sensitivity profoundly in the region of space represented by the sti
191 ther microglial genes, variants in TREM2 can profoundly increase the incidence of developing Alzheime
193 having no effect under normoxic conditions, profoundly increased vascular leak in both white and gra
194 rs, such as climate change and land use, may profoundly influence body size, density, and biomass of
195 the amplitude of CLR-induced NF-kappaB could profoundly influence host defense against fungal pathoge
197 ses, greatly increase proteome diversity and profoundly influence normal as well as pathological euka
202 These cell line effects on glycosylation profoundly influence the ability of the engineered Fcs t
204 tions associated with global change may thus profoundly influence the costs of long-distance migratio
205 ponents in the tumor microenvironment, which profoundly influence the different aspects of the metast
208 lts provide supporting evidence that ALD was profoundly influenced by host-gut microbiota metabolic i
209 of atomic van der Waals heterostructures are profoundly influenced by interlayer coupling, which crit
211 ides difficile colitis as enteric infections profoundly influenced by the microbiome's impact on bile
212 as Tau interactors whose binding to Tau was profoundly influenced by the presence or absence of the
214 of parental care received during development profoundly influences an individual's phenotype, includi
215 g beta2AR, we show that receptor redox state profoundly influences beta2AR orthosteric ligand binding
219 It appears that recent auditory history profoundly influences stimulus saliency, biasing animals
222 variable region 1 (VR1) of AAV1 and AAVrh.10 profoundly influences tropism, with altered SIA interact
223 tions efficiently outcompete host chromatin, profoundly influencing the way DNA-binding proteins expl
225 ced Ca(2+) elevations in mouse astroglia are profoundly inhibited by ethanol, an effect that can be r
226 ion on the surface of endothelial cells, but profoundly inhibited monocyte transmigration across endo
228 o therapeutic silencing of ATF4-FAM129A axis profoundly inhibited tumor growth in a preclinical PCa m
231 r endosomal Met/beta1-integrin/FAK signaling profoundly inhibits the oncogenic effects of both NRP1 v
232 tcomes following lung transplantation remain profoundly limited by chronic rejection, Treg therapy ho
236 of ALDH1A7 inducibility in the rr strain is profoundly linked with a 16-base pair deletion in the pr
239 e peritransplantation period, these APCs are profoundly modified by pathogen-associated molecular pat
241 of innate and adaptive immune responses and profoundly modulate the development of atherosclerosis.
242 ly indicate that repeated semen exposure can profoundly modulate the FRT microenvironment, paradoxica
243 d, for the first time, that Epac2 activation profoundly modulated the lesion environment by reducing
247 ar glutamate during neural activity can have profoundly negative consequences on synaptic plasticity.
251 tyrosine phosphatase non-receptor 3 (PTPN3) profoundly potentiates TGF-beta signaling independent of
253 COVID-19 pandemic challenges oncologists to profoundly re-organize oncological care in order to dram
255 purified IgG of three of four patients also profoundly reduced glycinergic currents compared with co
257 The association of MYPT1 with PP1cbeta was profoundly reduced in the presence of excess TIMAP, lead
259 ic SYK inhibition in a tauopathy mouse model profoundly reduced Tau accumulation, neuroinflammation,
261 were immunized with VSV-eGFP-SARS-CoV-2 show profoundly reduced viral infection and inflammation in t
263 Hematopoietic stem cell transplantation profoundly reduces allergen-specific IgE responses but a
266 ction analysis showed that ADAR1 suppression profoundly repressed proliferation, invasion, and migrat
267 alogues and show that the ATL interactome is profoundly reprogrammed following dengue virus infection
272 fect, and pharmacologic GSK3alpha inhibition profoundly sensitized drug-resistant leukemias to aspara
273 n with outer membrane permeability enhancers profoundly sensitizes Escherichia coli to designed LpxH
274 the RNA-editing enzyme ADAR1 in tumour cells profoundly sensitizes tumours to immunotherapy and overc
275 st that early childhood influenza infections profoundly shape later reactivity by creating an "imprin
277 Such recurrent, parallel mutation modes can profoundly shape the paths taken by evolution and underm
278 highly effective agents of erosion that have profoundly shaped Earth's surface, but there is uncertai
279 s into a dominant terrestrial group that has profoundly shaped the evolution of terrestrial life.
280 subsequent evolution under cultivation have profoundly shaped the genetic architecture of this biodi
284 terregulatory hormone (epinephrine) infusion profoundly stimulated adipocyte lipolysis and simultaneo
285 lycan ligand of the inhibitory receptor CD33 profoundly suppressed IgE-mediated activation of mast ce
286 tionated irradiation to thoracic region more profoundly suppressed KLF2 and enhanced ICAM-1 expressio
287 d to single exposure, fractionated radiation profoundly suppressed KLF2, TM, and eNOS levels, subdued
289 e that targeting surface-bound IgE with LARI profoundly suppresses human allergic reactivity while di
294 e advances provide exciting opportunities to profoundly transform synthetic biology by enabling new a
295 Here, we discover that ambient luminance profoundly transforms how mouse primary visual cortex (V
299 ressed high levels of CX3CL1, were marked by profoundly upregulated complement proteins (e.g., C1q an