ライフサイエンスコーパス: proglucagon

1 o prohormone convertase enzymes that process proglucagon .

2 1/3 blocked processing of proinsulin but not proglucagon.

3 he processing of the physiological substrate proglucagon.

4 also increased intestinal gene expression of proglucagon, a precursor of proteins that promote insuli

5 evaluate nutrient regulation of small bowel proglucagon and derived peptides, we evaluated the effec

6 tter characterize the sites of production of proglucagon and GLP-I in the small intestine and evaluat

7 articipates in the processing of proinsulin, proglucagon, and a variety of other neuroendocrine precu

8 t blocked production of mature glucagon from proglucagon, beta-cells retained the ability to produce

9 om alternate splicing of a common precursor, proglucagon by PC2 and PC1, respectively.

10 Taken together, these results suggest that proglucagon cleavage has a greater dependence on PC2 act

11 tly elevated Nogo-B expression and inhibited proglucagon cleavage in EECs from diabetic patients.

12 P-1) and glucagon-like peptide 2 (GLP-2) are proglucagon derived peptides that are released from gut

13 rily by the distal gut, although the role of proglucagon-derived glucagon-like peptide I (GLP-I) as a

14 e peptide 2 (GLP-2) is a nutrient-dependent, proglucagon-derived gut hormone that stimulates intestin

15 on-like peptide-2 (GLP-2) is a 33-amino-acid proglucagon-derived peptide secreted from enteroendocrin

16 ficient mice after the administration of the proglucagon-derived peptides (PGDPs) glucagon-like pepti

17 highlights the importance of a-cell-produced proglucagon-derived peptides, incretin hormones from the

18 ed for nutrient-regulated secretion of these proglucagon-derived peptides.

19 how that FXR activation in L cells decreases proglucagon expression by interfering with the glucose-r

20 s involved in pancreatic alpha-cell-specific proglucagon expression, we found that the POU domain tra

21 teral nutrient intake stimulates small bowel proglucagon expression; this effect is greater in jejunu

22 sing of proglucagon into glicentin and major proglucagon fragment and cleaved major proglucagon fragm

23 )-resident protein, interacts with the major proglucagon fragment of proglucagon to retain proglucago

24 major proglucagon fragment and cleaved major proglucagon fragment to release GLP-1 and tGLP-1, simila

25 Surprisingly, glicentin and major proglucagon fragment were sorted with different efficien

26 er initial processing to glicentin and major proglucagon fragment, leading to the hypothesis that sor

27 Peptides derived from pre-proglucagon (GCG peptides) act in both the periphery and

28 from dietary fibers, which regulates colonic proglucagon (Gcg) expression and small intestinal transi

29 GLP-1 is produced by cells that express proglucagon (GCG); however, the stimuli that activate GC

30 lines, TCF7L2 controls transcription of the proglucagon gene (gcg), which encodes the incretin hormo

31 oglycemia is in part associated with reduced proglucagon gene expression and glycogenolysis that resu

32 ith the BAS colesevelam increases intestinal proglucagon gene expression and improves glycaemia in a

33 reveal that brain 4 is a major regulator of proglucagon gene expression by its interaction with the

34 l and hepatic lipid metabolism and defective proglucagon gene expression contribute to hypoglycemia i

35 orrelated with a 70% reduction in pancreatic proglucagon gene expression.

36 The expression of the proglucagon gene has been demonstrated to be regulated b

37 romoter results in ectopic expression of the proglucagon gene in insulin-expressing pancreatic beta c

38 The proglucagon gene is expressed in a highly restricted tis

39 Cell-specific expression of the proglucagon gene is mediated by proteins that interact w

40 mechanism by which the transcription of the proglucagon gene is regulated in response to cAMP signal

41 NF3alpha could bind to and transactivate the proglucagon gene promoter.

42 ing cells that bind to the G1 element of the proglucagon gene proximal promoter.

43 ades later that has reshaped the view of how proglucagon hormones regulate metabolism.

44 es indicate the presence of large amounts of proglucagon in atypical appearing secretory granules in

45 ne transcription may explain the presence of proglucagon in certain areas of the brain as well as in

46 , which is mainly processed and cleaved from proglucagon in enteroendocrine cells (EECs) of the intes

47 examined the biosynthesis and processing of proglucagon in isolated islets from these mice via pulse

48 The differential processing of proglucagon in pancreatic alpha-cells and intestinal L c

49 ceride (LCT) for 24 h on local expression of proglucagon in proximal and distal small bowel.

50 hereby inhibiting PCSK1-mediated cleavage of proglucagon in the Golgi.

51 C1-6 cells, it accelerated the processing of proglucagon into glicentin and major proglucagon fragmen

52 Our previous work suggested that proglucagon is directed into granules by intrinsic sorti

53 Proglucagon is expressed in pancreatic alpha cells, inte

54 t efficiencies, thus providing evidence that proglucagon is first sorted to granules prior to process

55 Proglucagon is processed to glucagon and glucagon-like p

56 Intestinal proglucagon is thought to be synthesized primarily by th

57 o efficiently cleave the interdomain site in proglucagon (KR 70-71).

58 ered prodomains, the sorting determinants of proglucagon lie within the ordered hormone domains of gl

59 The proglucagon-like hormones glucagon-like peptide 1 and 2

60 ileum, fasting resulted in a 20% decrease in proglucagon mRNA (P < 0.005); in contrast to jejunum, re

61 Proglucagon mRNA abundance and cellular localization wer

62 In jejunum, proglucagon mRNA abundance decreased by 40% with fasting

63 id not result in a significant rise in ileal proglucagon mRNA abundance from fasting values.

64 Diacetyl decreased proglucagon mRNA and total GLP-1 from glucose stimulated

65 ection significantly increased expression of proglucagon mRNA in colon.

66 develop normally in HNF-3alpha-/- mice, but proglucagon mRNA levels are reduced 50%.

67 In jejunum, signal intensity of proglucagon mRNA per cell, determined by in situ hybridi

68 gon and GLP-I levels correlated with jejunal proglucagon mRNA.

69 roglucagon fragment of proglucagon to retain proglucagon on the ER, thereby inhibiting PCSK1-mediated

70 The family of proglucagon peptides Includes glucagon and glucagon-like

71 To address which proglucagon peptides stimulate insulin secretion, we dev

72 alpha cells secrete proglucagon peptides to regulate nutrient metabolism.

73 des (GLP-1 and GLP-2) are processed from the proglucagon polypeptide and secreted in equimolar amount

74 peptide (GLP)-1 are the primary products of proglucagon processing from the pancreas and gut, respec

75 These studies show plasticity in proglucagon processing to support alpha cell-to-beta cel

76 er pituitary or pancreatic alpha cell lines, proglucagon processing was preferentially decreased when

77 on factor brain 4 is abundantly expressed in proglucagon-producing islet cell lines and rat pancreati

78 nded adeno-associated virus containing a rat proglucagon promoter (700 bp) driving enhanced green flu

79 pressing a fluorescent protein driven by the proglucagon promoter.

80 f ATF3 and ATF3b on the CRE/ATF motif of the proglucagon promoter.

81 als expressing Cre recombinase under the pre-proglucagon promoter.

82 The processing of proglucagon, prosomatostatin, and proinsulin in the alph

83 with morphological evidence of high rates of proglucagon secretion in PC2 null islets.

84 e discovery of novel peptides encoded in the proglucagon sequence and the establishment of their phys

85 unal infusion of LCT increased expression of proglucagon to a greater extent in jejunum than in ileum

86 2, convert proinsulin to insulin and convert proglucagon to glucagon and glucagon-like peptide 1 (GLP

87 , islet proinsulin to insulin and intestinal proglucagon to glucagon-like peptide-1 and -2.

88 plays an essential role in the processing of proglucagon to mature active glucagon in pancreatic alph

89 racts with the major proglucagon fragment of proglucagon to retain proglucagon on the ER, thereby inh

90 mice via pulse-chase labeling and find that proglucagon undergoes essentially no processing in chase

91 Surprisingly, when proopiomelanocortin and proglucagon were co-expressed in either pituitary or pan

92 Tissue-specific processing of proglucagon yields three major peptide hormones as follo