ライフサイエンスコーパス: programmable

1 microfluidic platform is fully automated and programmable.

2 -cell sorting technique that is flexible and programmable.

3 x objects demonstrates its broad utility for programmable 2D nanoscale materials.

4 feasible and economical method to fabricate programmable 2D patterns of chiral PDA with tailored chi

5 with the same cut design can self-fold into programmable 3D kirigami metastructures with distinct me

6 ults create many opportunities for advanced, programmable 3D microsystem technologies.

7 ex cryptography with the ASCII code within a programmable 6x6 lattice is demonstrated to demosntrate

8 Programmable A > I RNA editing is a valuable tool for ba

9 e base editors (for example, ABE7.10) enable programmable A*T to G*C point mutations but editing effi

10 These UCNPs allow programmable activation of two synergistic light-gated i

11 ellular structures and forces and to develop programmable active-matter devices.

12 The programmable actuator can mimic the claw of a hawk to gr

13 ect a single comb line using an electrically programmable add-drop filter, and modulate the intensity

14 we describe a CRISPR-Cas9-based synchronous programmable adenine and cytosine editor (SPACE) that ca

15 Previously, we developed a programmable adenosine-to-inosine (A-to-I) RNA editing a

16 icant relevance to ongoing efforts to design programmable and adaptable replicator networks.

17 moire ferroelectricity may enable ultrafast, programmable and atomically thin carbon-based memory dev

18 ologies that have led to the introduction of programmable and automatic as well as large-scale enzyma

19 The system is highly programmable and can generate expandable AND gates with

20 ategy to make a robotic machine that is both programmable and compatible with colloidal-scale physics

21 with their protein analogues, GRAP is highly programmable and exhibits reduced off-target effects.

22 t allows CRISPR to be widely utilized is the programmable and highly selective mechanism.

23 Together, we provide a programmable and in vivo manipulation tool to study mRNA

24 lent building material for the production of programmable and multifunctional objects.

25 ogy has established approaches for designing programmable and precisely controlled nanoscale architec

26 nded DNA rotaxane for its ability to undergo programmable and predictable conformational changes.

27 rotein binders at each locus are eluted in a programmable and selective fashion.

28 Establishing programmable and self-sustaining replication networks in

29 s or protein/nucleic acid complexes is under programmable and spatiotemporal control to maintain cell

30 ive fiber-drawing technique to create strain-programmable artificial muscles with dimensions spanning

31 table nature of DNA interactions enables the programmable assembly of highly advanced 2D and 3D DNA s

32 ultiple, diverse meroterpene chemotypes in a programmable assembly process involving a minimal number

33 he most sophisticated architectures made via programmable assembly, and their formation can be unders

34 iral optical materials, as well as informing programmable assembly.

35 generalized approach yields customizable and programmable aTF-regulated promoters for engineering cel

36 , DNA-nanoparticle conjugates are considered programmable atom equivalents (PAEs), and design rules h

37 smonic superlattice microcavities, made from programmable atom equivalents comprising gold nanopartic

38 densely modified with DNA can be viewed as "programmable atom equivalents" (PAEs).

39 ay the groundwork for future construction of programmable auto-luminescent plant traits, such as ligh

40 ping self-fueled micro-reactor droplets with programmable autonomic behaviors provides a step towards

41 PER synthesis happens in a programmable, autonomous, in situ and environmentally re

42 Here we utilize two programmable barcoding methods based on base-pairing, na

43 ic repeats (CRISPR), CRISPR interference and programmable base editing have transformed the manipulat

44 Here, we exploited CRISPR interference and programmable base editing to determine their potential i

45 Here, we report a programmable "base editing" system to induce precise bas

46 Programmable behavior combined with tailored stiffness a

47 The approach of programmable bioinstructivity provides a fundamental pri

48 has not fully explored the possibilities for programmable biomolecular interaction modalities.

49 DNA is a highly programmable biomolecule and has been used to construct

50 Polypeptides and polynucleotides are natural programmable biopolymers that can self-assemble into com

51 ore offers an innovative strategy for making programmable cascades of genes that can be used for gene

52 Herein, we present a programmable chemical processor comprising of a 5 by 5 a

53 d be a reliable algorithmic component within programmable chemical systems.

54 nding not only opens a pathway for producing programmable chiroptical micropatterns, but also is high

55 tion system in which CO2 is introduced using programmable CO2 pressures across a membrane into a flow

56 res, fabricating mechanochromic systems with programmable colorimetric responses remains challenging.

57 se where the skin provides an electronically programmable communication and sensory input channel to

58 iber/polymer hybrid materials having locally programmable complex electrical, thermal and mechanical

59 nt-addressable memory stores data within the programmable conductance and can take as input either an

60 in significantly lower power due to very low programmable conductance states, motivating CAM use in a

61 olatile memristive synapses with arbitrarily programmable conductance states.

62 mbinations of just a few monomers enable the programmable construction of rotationally restricted, no

63 Programmable control of gene expression from aTF-regulat

64 Programmable control of gene expression is essential to

65 directional control of biological processes, programmable control requires orthogonal non-overlapping

66 , a genome-editing approach that enables the programmable conversion of one base pair into another wi

67 Programmable cooperative assembly provides a versatile w

68 localization in human cells, and demonstrate programmable CRISPR RNA (crRNA)-mediated targeting of sp

69 Here, we describe the development of a programmable CRISPR system capable of specifically visua

70 results expand the available toolset of RNA-programmable CRISPR-associated nucleases.

71 peptides (CMPs), are employed as molecularly programmable crystallizable units.

72 gineered temperate phage lambda expressing a programmable dCas9 represses a targeted E. coli gene in

73 er administration in peripheral tissues with programmable degradable linkers.

74 the great potential of using DLDs to achieve programmable degradation of materials.

75 Yu et al. show programmable, densely packed clusters using thermally ex

76 etamaterial with m n-unit MPs, the number of programmable displacement-force curves increases from n+

77 lattices with defined crystal habits through programmable DNA "bonds".

78 ineering efforts to leverage this system for programmable DNA insertions in genome-engineering applic

79 embly of DNA nanotubes-a well-known class of programmable DNA nanostructures.

80 The predictable and programmable DNA strands have paved the way for cellular

81 These molecules are composed of programmable DNA-binding ligands flexibly tethered to a

82 chemical synthesis with the specificity of a programmable DNA-binding protein by using protein trans-

83 e editing by nucleotide deaminases linked to programmable DNA-binding proteins represents a promising

84 t together on target DNA by adjacently bound programmable DNA-binding proteins.

85 DNA nanotechnology allows for the design of programmable DNA-built nanodevices which controllably in

86 RISPR-CasX, which uses unique structures for programmable double-stranded DNA binding and cleavage.

87 ergy and information on solid surfaces using programmable droplets as vessels.

88 ated new opportunities to use site-directed, programmable drug delivery systems to treat auditory and

89 lectrophysiological parameters and allow for programmable electrical stimulation, radiofrequency abla

90 ally enable very large-scale CMOS-integrated programmable electronic-photonic systems such as optical

91 ble Endonucleases (Y-CHOPE), incorporating a programmable endonuclease that 'shreds' the Y chromosome

92 e ribose dependency of Cas9 to develop a XNA-programmable endonuclease.

93 ermed Y-CHromosome deletion using Orthogonal Programmable Endonucleases (Y-CHOPE), incorporating a pr

94 Both pAgos can perform programmable endonucleolytic cleavage of double-stranded

95 plex as a unique example of a protein-guided programmable endoribonuclease.

96 Accordingly, here, a programmable epidermal microfluidic valving system is de

97 and extensible platform for regulating four programmable exons that undergo a mutually exclusive alt

98 We demonstrate programmable fabrication of three-dimensional (3D) mater

99 d-hole" (BH)-GalNAc-T2, boosts labeling in a programmable fashion by increasing incorporation of GalN

100 ion and protein biosynthesis in a timely and programmable fashion.

101 of a synthetic code that enables a sequence programmable feature like DNA represents a key aspect to

102 rial predator-prey pursuits in habitats with programmable features.

103 Our method capitalizes on programmable flow analysis, in which gastrointestinal ex

104 This article reports for the first time a programmable-flow-based mesofluidic platform that accomm

105 The programmable FNA is designed using three DNA triangular

106 ndle yields monodisperse macromolecules with programmable folding and self-assembly properties.

107 with micron-sized pillars that can beat at a programmable frequency and force level in an electromagn

108 e development of soft modular materials with programmable functionality.

109 ser and the camera are controlled by a Field Programmable Gate Array (FPGA) with IoT capabilities.

110 For the sake of efficiency, we use a field programmable gate array for strictly hardware-based comp

111 ousto-optic lens and rapid closed-loop field programmable gate array processing to track 3D brain mov

112 those achieved in other fields such as field-programmable gate arrays (FPGA).

113 sign to accelerate pre-alignment using Field-Programmable Gate Arrays (FPGAs), which can perform pre-

114 d data acquisition systems, as well as field-programmable gate arrays (FPGAs).

115 ferent approach inspired by electronic Field Programmable Gate Arrays is the programmable photonic pr

116 CRISPR-Cas technologies have enabled programmable gene editing in eukaryotes and prokaryotes.

117 ery cell in the human body contains a set of programmable gene-silencing proteins named Argonaute.

118 system provides a new opportunity to create programmable gene-specific antimicrobials that are far l

119 Moreover, the proposed programmable genetic circuits may be expanded to enginee

120 at developing and deploying this enzyme for programmable genetic editing.

121 CRISPR/Cas9 is a programmable genome editing tool widely used for biologi

122 ISPR-Cas systems provide versatile tools for programmable genome editing.

123 n provide an efficient mean for constructing programmable, higher-order, and complex DNA objects, as

124 as systems provide bacteria and archaea with programmable immunity against mobile genetic elements.

125 lass of single-molecule effectors possessing programmable inputs and outputs.

126 Here, we establish Saturated Programmable Insertion Engineering (SPINE), an unbiased,

127 ncoded CRISPR-Cas system to make RNA-guided, programmable insertions.

128 In the field of DNA nanotechnology, we use programmable interactions between nucleic acids to gener

129 we use a Rydberg atom quantum simulator with programmable interactions to study the quantum critical

130 (Mo-DBRS) platform that enables wireless and programmable intracranial electroencephalographic record

131 evious base editors, ABEs enable the direct, programmable introduction of all four transition mutatio

132 st, we demonstrate potential applications of programmable kirigami machines and easy-turning soft rob

133 Programmable kirigami metamaterials with controllable lo

134 e developed spectrally optimized light using programmable LED arrays (PLA)s to study the effect on al

135 he next generation of protocells imbued with programmable, lifelike behaviors.

136 tonomously self-resettable DSD cascades with programmable lifetimes are still missing.

137 Moreover, the use of a chemically programmable ligand, such as DNA, would allow for the ma

138 available materials at these scales are not programmable like their macroscopic counterparts.

139 e matter, energy-dissipative assemblies, and programmable liquid constructs.

140 imple PHE device, hold promise for realizing programmable logic elements in magnetic electronics.

141 ays of photosensors on plastic and paper and programmable logic memory devices.

142 ries, thereby demonstrating the potential of programmable long-term electrical stimulation for mainta

143 o n-type metal-oxide nanocrystals, producing programmable LSPR redshifts due to dopant compensation.

144 ew experimental strategy incorporating pulse-programmable magnetic field sweeping and in situ detecti

145 itch-based editing of two loci in a strictly programmable manner and determined the order of mutageni

146 or precisely modulating these functions in a programmable manner.

147 oparticle conjugates, which may be useful as programmable material building blocks and as probes for

148 s offer insight into a wide variety of shape-programmable materials and capillary assemblies, simply

149 Shape programmable materials offer tremendous functionality, b

150 computational systems, smart actuators, and programmable materials.

151 xternal stimuli are critical to soft robots, programmable matter, and smart medicine.

152 provides an advanced approach for designing programmable mechanochromic devices with the desired pre

153 nesthesia, we used a behavioral study with a programmable mechatronic device that stretches the skin

154 The use of programmable meganucleases is transforming genome editin

155 f particular importance are the adaptive and programmable membranes that can change their permeabilit

156 DNA origami has emerged as a highly programmable method to construct customized objects and

157 ble with structures made by conventional DNA programmable methods and without the influence of a matr

158 ucidate the rules of synthetic, functionally programmable microbiome assembly, (4) determine function

159 sed on these observations, we developed cPPA programmable microcapsules whose payload release rates d

160 Using electronically programmable microfluidics, the measurement is in turn u

161 printing and stamping, direction- and track-programmable microparticle/droplet transport, and smart

162 The programmable microreactor designed through the arrangeme

163 Our method is to fabricate a programmable microreactor that can be easily manufacture

164 to be precisely controlled, we designed the programmable microreactor to be driven under centrifugal

165 The development of programmable microscale materials with cell-like functio

166 first self-assembled in nanocomposites with programmable microscopic shapes.

167 This method will enable the realization of programmable miniaturized integrated optoelectronic devi

168 We anticipate that future generations of programmable molecular machines may have significant rol

169 etrieval of tertiary structural behavior and programmable molecular recognition capabilities.

170 ction and have been creatively repurposed as programmable molecular scalpels for surgical manipulatio

171 multi-stimuli response can form the basis of programmable molecular systems, wherein specific input s

172 Modular construction of an autonomous and programmable multi-functional heterogeneous biochemical

173 A programmable multivalve manifold selects Hg at the analy

174 le different ligand-responsive units to form programmable nanodevices for advanced biocomputation.

175 as a unique class of compounds that combine programmable nanoscale building blocks and atomic precis

176 DNA nanostructures with programmable nanoscale patterns has been achieved in the

177 Here, a bioinspired, programmable nanotechnology-based platform is described

178 acman The material-agnostic, scale-free, and programmable nature of our design enables building a var

179 (or programming language) of CRNs due to its programmable nature.

180 ity to encode multi-stable metasurfaces with programmable non-Euclidean geometries.

181 Current programmable nuclease-based methods (for example, CRISPR

182 till for some time, recent demonstrations of programmable nuclease-based technology suggest that clin

183 to double-stranded DNA breaks (DSBs) made by programmable nucleases (e.g. CRISPR-Cas9).

184 nd broadly applicable methods for delivering programmable nucleases and donor templates for homology-

185 rs and have the potential to be harnessed as programmable nucleases for genome editing.

186 termining the off-target cleavage profile of programmable nucleases is an important consideration for

187 Genome editing using programmable nucleases is revolutionizing life science a

188 dvances in gene editing have been enabled by programmable nucleases such as transcription activator-l

189 ave advanced greatly with the development of programmable nucleases, but methods for quantifying on-

190 Programmable nucleases, such as Cas9, are used for preci

191 gh efficiency, specificity, and flexibility, programmable nucleases, such as those of the clustered r

192 report that programmable nucleases-TALENs and CRISPR/Cas9-can safely

193 fering a versatile new tool for constructing programmable nucleic acid components in medicine, nanote

194 Toehold switches, which are programmable nucleic acid sensors, face an analogous des

195 ure enables analyte detection via the highly programmable nucleic acid shell or a functional protein

196 CRISPR-Cas systems are efficient and easily programmable nucleic acid-targeting tools, with uses rea

197 Taking advantage of programmable octahedral DNA frame, we report a facile ap

198 Delivery rates of hundreds/min with programmable off-times of the pore are demonstrated usin

199 Here, we introduce a programmable optofluidic chip for nanopore-based particl

200 m enables high-yield CM generation and their programmable organization in hierarchical nanostructures

201 Here we report stable non-volatile programmable p-n junctions fabricated from the verticall

202 locomotion via coded illumination, we design programmable pathways of nature-inspired angular locomot

203 we provide new guidelines for the design of programmable pathways to improve the self-assembly of DN

204 ommunicate information via spatio-temporally programmable patterns of localized mechanical vibrations

205 heater was performed by means of a developed programmable PCR apparatus.

206 n 11 (KLHL11) was identified with the use of programmable phage display.

207 Here, we performed proteome-wide programmable phage-display (PhIP-Seq) on sera from a coh

208 tronic Field Programmable Gate Arrays is the programmable photonic processor, where a common hardware

209 This work represents a step towards programmable photoswitchable regulation of a wide variet

210 The CRISPR-Cas system offers a programmable platform for eukaryotic genome and epigenom

211 development of RNA-DNA hybrid nanoshapes as programmable platforms for applications in molecular rec

212 We employ a programmable polymer actuator sheet to autonomously sync

213 Here we develop a programmable polymer library by including responsive uni

214 This allows fabrication of membranes with programmable, predetermined permeability and selectivity

215 ew avenue to expand the application scope of programmable probes with selectivity beyond A, G, T and

216 Based on the non-volatile programmable properties controlled by gate voltages, the

217 rs to self-assembled materials with advanced programmable properties.

218 ks is an important step toward the design of programmable protein self-assembly via pseudosymmetric p

219 These results highlight the applicability of programmable protein switches to metabolic engineering f

220 lated with fine-gauge needles connected to a programmable pump and saline reservoir, respectively.

221 ere, we present an 11-qubit fully-connected, programmable quantum computer in a trapped ion system co

222 The challenge is to achieve a fully programmable quantum device featuring coherent adiabatic

223 a way of exploring many-body phenomena on a programmable quantum simulator and could enable realizat

224 Using a programmable quantum simulator based on neutral atom arr

225 The adapted tool combines a programmable reagent delivery system with temperature co

226 ins that can serve as probes for the direct, programmable recognition and analysis of epigenetic nucl

227 f living cells, functional biomaterials, and programmable release capsules.

228 towards complex mesoscale dynamics based on programmable response-retaliation behavior in artificial

229 for incorporation into systems with complex, programmable responses to different sets of stimuli.

230 tosine base editors (CBEs) enable efficient, programmable reversion of T*A to C*G point mutations in

231 These single-nucleotide-specific programmable riboregulators (SNIPRs) provide over 100-fo

232 smaller than naturally occurring CRISPR-Cas programmable RNA binding systems but can also be built e

233 rotein engineering strategy for constructing programmable RNA control elements.

234 Programmable RNA cytidine deamination has recently been

235 Programmable RNA editing enables reversible recoding of

236 two endonuclease-deficient, single-component programmable RNA-guided and RNA-targeting Cas13 RNases (

237 s/CRISPR-associated (CRISPR/Cas) system as a programmable, RNA-guided endonuclease has revolutionized

238 This discovery of a fully programmable, RNA-guided integrase lays the foundation f

239 which uses a Type I-F CRISPR-Cas system for programmable, RNA-guided transposition.

240 A dedicated programmable sample flow rate scanner was used to infuse

241 shframe with high spatial symmetry as a site-programmable scaffold, which can be prescribed with desi

242 Bacterial biosensors can enable programmable, selective chemical production, but difficu

243 -modified polypeptides (CHaMPs) that exhibit programmable self-assembly at the nanoscale.

244 asing complexity have showcased the power of programmable self-assembly from DNA strands.

245 NA building blocks as functional modules for programmable self-assembly of a versatile toolkit of pol

246 otides as a molecular building block for the programmable self-assembly of nanostructured systems-was

247 Programmable self-assembly of smart, digital, and struct

248 on magnetic encoding of information to drive programmable self-assembly that works across length scal

249 nucleic acids' ability to encode folding and programmable self-assembly through mainly base pairing.

250 abricate a supramolecular peptide that shows programmable self-assembly with multiple morphologies an

251 the synthetic manifestation of a temporally programmable self-assembly.

252 y controllable residual stresses that enable programmable, self-bending behavior.

253 CRISPR-associated nuclease Cas12a as a user-programmable sensor and material actuator.

254 We show measurements wherein a user-programmable set-point precisely alters the protein conc

255 duce large, well-defined macromolecules with programmable shape, size, and chemistry that combines re

256 SABER offers independently programmable signal amplification without in situ enzyma

257 rk any gene (or DNA element) by pairing of a programmable single guide RNA (sgRNA) with a complementa

258 alytically inactive Cas9 protein (dCas9) and programmable single guide RNAs, has emerged as a powerfu

259 the outputs of DNA computing and to develop programmable smart diagnostic nanodevices.

260 By exploiting the programmable SNIPR design, we implement an automated des

261 Shape-programmable soft materials that exhibit integrated mult

262 s sensitive to low light intensities and has programmable states and rapid and highly controlled actu

263 Programmable stiff sheets with a single low-energy foldi

264 joint were activated transcutanously using a programmable stimulator, and the resultant finger flexio

265 heterogeneous and on-demand actuation using programmable stimuli-responsive micro/nanostructures.

266 ic computing algorithms require electrically programmable stochasticity to encode arbitrary probabili

267 This programmable strategy leads to the precise incorporation

268 e type of stimulus and are unable to achieve programmable structural changes under different stimuli.

269 pond to humidity, temperature and light, via programmable structural changes.

270 DNA's ability to form versatile and complex programmable structures.

271 and opens vast opportunities for multiscale programmable structures.

272 Here we report the use of a processor with programmable superconducting qubits(2-7) to create quant

273 ctional self-assembly of nanoparticles using programmable surface adapters.

274 cles (glycodendrimersomes) with a chemically programmable surface.

275 Using programmable switches, this phononic structure allows fo

276 Here, we report a composition-programmable synthesis of multimetallic phosphide CoMP(x

277 This strategy may open a door for a programmable synthesis of supra-nanoscale structures wit

278 need for reproducible, robust, scalable, and programmable synthetic methods to generate macromolecule

279 The programmable synthetic microenvironment thus allows for

280 Here, we describe programmable synthetic organelles based on highly stable

281 ith important implications for the design of programmable synthetic systems.

282 gned at will, promising their future use for programmable, target-oriented mineralization control.

283 up pathways to next-generation DNA materials programmable through sequence recognition and available

284 rotein on a double-helix stage that has user-programmable tilt and rotation angles.

285 eighboring memory cells and read out after a programmable time with high fidelity.

286 op-mediated isothermal amplification (LAMP), programmable toehold-mediated strand-exchange signal tra

287 Engineered RNA elements are programmable tools capable of detecting small molecules,

288 Synthetic biology aims to develop programmable tools to perform complex functions such as

289 Here, we report a modular system based on programmable transcription activator-like effector (TALE

290 led to diverse applications in gene editing, programmable transcriptional control, and nucleic acid d

291 oped synthetic tissue groupings that allowed programmable transformation of two-dimensional (2D) stre

292 2L to RNA-targeting CRISPR-Cas9 demonstrates programmable translational enhancement.

293 s an overview of recent progress towards the programmable transport of droplets on solid surfaces.

294 possible future research directions for the programmable transport of droplets.

295 inct CRISPR-Cas mechanisms for site-specific programmable transposition in prokaryotic organisms.

296 Programmable transposition of Vibrio cholerae Tn6677 in

297 n be rationally formed using components with programmable valence.

298 fast (1-2 min) temperature transitions with programmable waveforms between room temperature and 45 d

299 edit endogenous transcripts in a simple and programmable way, an approach we call RESTORE (recruitin

300 tor activity of mice for over four weeks via programmable wireless drug delivery and photostimulation