ライフサイエンスコーパス: proline

1 cting stress-induced accumulation of ABA and proline.

2 ric complex, whose abundance is regulated by proline.

3 h could interact with SNs proteins and honey proline.

4 d cases were observed when used with d- or l-proline.

5 tannin structure and reactivity with poly-l-proline.

6 PPIases) catalyze cis/trans isomerization of prolines.

7 orders of magnitude over the same number of prolines.

8 e of cis conformers is observed for terminal prolines.

9 y shows that CypA catalyzes isomerization of proline 128 in the C-terminal domain of alpha-synuclein.

10 protein level via a mechanism requiring ADSL proline 24 hydroxylation.

11 e stereochemistry of monofluorination at the proline 3- or 4-position, different effects on the confo

12 monolayers (SAMs) of right-handed helical (l-proline)(8) (Pro(8)) and corresponding peptides, N-termi

13 milar levels of cis conformation as isolated prolines, a length-dependent reduced abundance of cis co

14 Buta increased free proline accumulation by inducing the activity of Delta(1

15 Consistently, proline addition promotes the expression of these inflam

16 ons showed increased activation of the Ste20 proline alanine-rich kinase-Na+-Cl- cotransporter (SPAK-

17 tics with paratopes containing potential cis proline amide bonds.

18 demonstrated proof-of-concept for screening proline analogs to discover inhibitors of the proline cy

19 we performed a small-scale focused screen of proline analogs using X-ray crystallography.

20 These Imi scaffolds behave as proline analogues characterized by a flat structure and

21 tes rose upon desiccation, while putrescine, proline and a variety of sugars rose in winter.

22 n substantial amounts (5-8 mg/g), as well as proline and arginine (~5 mg/g).

23 (GSAL), a mitochondrial intermediate of the proline and arginine catabolism, to glutamate.

24 each first IA preceded by reduced amino acid proline and branched-chain amino acids (BCAAs), respecti

25 ependent enteroviruses; however, a conserved proline and glycine seem to be key residues.

26 Two osmolytes, proline and glycine-betaine, are then shown to recharge

27 the total soluble sugars, total carotenoids, proline and grain hardness found to be in positive relat

28 ne, valerate, propionate, glucose, tyrosine, proline and isoleucine.

29 uctural effects that are typically linked in proline and its pyrrolidine-substituted analogues.

30 ith specific overrepresented regions rich in proline and other hydrophobic residues.

31 me metabolites (valine, leucine, isoleucine, proline, and malic acid).

32 Proline- and arginine-rich peptide PR11 is an allosteric

33 It is induced by digestion-resistant, proline- and glutamine-rich seed storage proteins, colle

34 rain, we found that two central, consecutive prolines are important for cell-cell fusion and pathogen

35 R-DPRs), poly-glycine arginine (GR) and poly-proline arginine (PR), and are protective in genetic mod

36 ouse model engineered to express poly(PR), a proline-arginine (PR) dipeptide repeat protein synthesiz

37 ts, including poly glycine-arginine and poly proline-arginine, as the main culprits of NMD inhibition

38 A proline-arginine-rich sequence within the LCD binds to m

39 The proline/arginine-rich domain of Dyn2 is important for it

40 al ions and internal fragments N-terminal to proline as diagnostic ions to confirm the deamidation si

41 reover, introduction of lysine, glutamine or proline at residue A578 also elicited capsaicin sensitiv

42 e generated in situ from ninhydrin and (thia)proline at the C=C bond of corresponding enedione, follo

43 the secondary structures, the propensity for proline at these regions is likely due to its tendency t

44 A proline-based imidazolidinone was synthesized and used a

45 We optimized our previously reported proline-based STAT3 inhibitors into an exciting new seri

46 In agreement with leucine and proline being the most frequently methylated tRNA isoacc

47 d investigation of a PRD (166 residues; ~30% prolines) belonging to a human protein ALIX, a versatile

48 h more abundant in E. limosum cells grown on proline betaine than on lactate.

49 A catalyze tetrahydrofolate methylation with proline betaine, thereby forming a key intermediate in t

50 Thus, proline biosynthesis acts as a redox vent, preventing th

51 2) breast cancer cells by inhibiting de novo proline biosynthesis and impairing spheroidal growth.

52 olism by up-regulating the proline cycle and proline biosynthesis, and knockdowns of PYCR1 lead to de

53 ased mitochondrial redox generation promoted proline biosynthesis, while reducing mitochondrial redox

54 edox potential and/or ATP synthesis impaired proline biosynthesis.

55 catalyze the cis-trans isomerization of xaa-proline bonds, a rate-limiting step in protein folding w

56 Here, we report a critical role for proline catabolism in non-small cell lung cancer (NSCLC)

57 Using only proline catalysis, heteroaryl-substituted acetaldehydes

58 This protocol involves the proline-catalyzed direct Mannich reaction-cyclization/IB

59 xyhexahydrocannabinol, is achieved through a proline-catalyzed inverse-electron-demand Diels-Alder re

60 pproach, a core structure is constructed via proline-catalyzed Mannich reaction and subsequently deri

61 A proline-centered pentapeptide isoconformational to arach

62 percentages derived from a large database of proline-centered tripeptides extracted from crystallogra

63 A beta-proline CF(3)-tripeptide with alternating absolute chira

64 he synthesis of two novel bridged morpholine-proline chimeras 4 and 5, which represent rigid conforma

65 howed higher concentrations of hypoxanthine, proline, choline and acetylcholine and decreased concent

66 ntially controls translational activation of proline codon rich profibrotic genes in cardiac fibrobla

67 t biomass, relative water content, sugar and proline concentrations and F(v) /F(m) ) are enhanced in

68 nd propensity to adopt non-binding competent proline conformers provides novel insight into the slow

69 an alternative oxidase (AOX), an increase in proline consumption, elevated activity of complex II, an

70 roach resulted in the discovery of eight new proline-containing cyclic nonribosomal peptides, which w

71 egion" has low sequence complexity, has high proline content, and lacks predicted secondary structure

72 This exon codes for 40 aa with a high proline content, consistent with an unstructured loop pr

73 The application of ABA or proline could alleviate stress-induced oxidative damage

74 heir proline metabolism by up-regulating the proline cycle and proline biosynthesis, and knockdowns o

75 alyzes the biosynthetic half-reaction of the proline cycle by reducing Delta(1)-pyrroline-5-carboxyla

76 roline analogs to discover inhibitors of the proline cycle.

77 Leucine, proline, cysteine, and tryptophan concentrations were no

78 carboxylate synthetase (P5CS) and decreasing proline dehydrogenase (PDH) activity, while Si reversed

79 F15, aminoacid catabolizing enzymes, notably proline dehydrogenase (POX), and adipose triglyceride li

80 Proline dehydrogenase (PRODH) is activated to reduce pro

81 Using this proline-deleted MHV strain, here we investigated whether

82 We observed that the proline-deleted recombinant MHV strain is restricted to

83 ino acid derivative to rationally target the proline-dependency of tumour growth.

84 h are downregulated/upregulated when the cis-proline-dependent Ssu72 CTD phosphatase is inactivated.

85 chemical microreactor design to oxidise an L-proline derivative at room temperature in continuous flo

86 oxide moiety formed upon 1,2-addition of the proline derivative to the ketone.

87 f l-tyrosine- or l-leucine-derived 4-alkyl-l-proline derivatives (APDs) in their structures.

88 structurally simple and easily accessible l-proline derived aminocatalyst, phenyl l-prolinamide, for

89 nded our library of conformationally defined proline-derived modules (ProMs) to succeed in developing

90 hree out of the four possible 3,4-difluoro-l-proline diastereoisomers.

91 DYRK1A is a proline-directed kinase that phosphorylates cyclin L2 at

92 early consequence of tau phosphorylation by proline-directed kinases is postsynaptic dysfunction ass

93 dephosphorylation of S319 and possibly other proline-directed sites and retention of Y359 and S362 ph

94 We conclude that an intact proline dyad in the FP of the recombinant demyelinating

95 cis-trans isomerization of CTD prolines expands the scope of the code in ways that are

96 A cycle, TGFbeta induced the biosynthesis of proline from glutamine in a Smad4-dependent fashion.

97 All possible variants of beta-proline functionalized tripeptides consisting of homo/he

98 Mutants in other proline-glutamate (PE)/PPE clusters, responsive to magne

99 octamer-binding protein and splicing factor proline/glutamine-rich.

100 In particular, the proline/glycine kink in helical peptides was reported to

101 The position of the proline/glycine kink in the sequence further controls th

102 est propensity for hinge-bending regions and proline has the highest, even though it is the most rigi

103 Loss of this complex perturbs mitochondrial proline homeostasis and cellular redox balance.

104 Phosphoramidates of proline hydrolyzed fast, with a half-life time as short

105 endent dioxygenase family, including the HIF proline hydroxylase (PHD, alias EGLN), and an E3 ubiquit

106 ox enhancer elements in the promoters of the proline hydroxylase domain (PHD) proteins to increase ex

107 y protein internalization via O(2)-dependent proline hydroxylation and subsequent ubiquitination by a

108 Here we report that ChREBP is modified by proline hydroxylation at several residues.

109 Thus, proline hydroxylation of ChREBP is a novel post-translat

110 Proline hydroxylation targets both ectopically expressed

111 difications including tyrosine sulfation and proline hydroxylation within, and proteolytic maturation

112 Peptides designed to include a glycine-proline-hydroxyproline (GPO) amino acid triad are biomim

113 Recently, a GRE, trans-4-hydroxy-L-proline (Hyp) dehydratase (HypD), was discovered that ca

114 of 16 isobaric reagents based on an isobutyl-proline immonium ion reporter structure (TMTpro) is pres

115 responses, there is a prompt accumulation of proline in leaves and effective protection of chlorophyl

116 ent, in contrast to the presence of a single proline in the chain.

117 We found that a highly conserved proline in the CMGC insert of the DYRK1 kinase domain is

118 at the cis/trans conformation of a conserved proline in the cyclic nucleotide-binding domain determin

119 otide substitution in the OXT gene codes for proline in the eighth residue position (Pro(8)-OT).

120 For example, the presence of proline in the ribosome's P- or A-site slows down transl

121 ng WT but not ChREBP that lacks hydroxylated prolines in ChREBP-deleted hepatocytes.

122 Screening prolines in different positions in long (poly-P(11)) and

123 L) determined that the rigidity conferred by prolines in ECL3 are essential for PAR4 activation.

124 bsence, respectively, of the two consecutive prolines in FP.

125 the inability to model mutations to and from prolines in which the bonded topology of the backbone is

126 he cis isomer could not be detected in inner prolines, in line with percentages derived from a large

127 teracts with HSF1 protein at a noncanonical, proline-independent SH3 interaction motif.

128 d component, PROLINE-TRYPTOPHANE-TRYPTOPHANE-PROLINE INTERACTOR OF POLYCOMBS1, in Arabidopsis (Arabid

129 Proline is found in a cis conformation in proteins more

130 Catalysis of cis/trans isomerization of prolines is important for the activity and misfolding of

131 f alpha-synuclein reverses the action of the proline isomerase and turns it into a potent molecular c

132 r a non-enzymatic function of a spliceosomal proline isomerase.

133 Removal of the proline isomerization barrier through posttranslational

134 Catalysis of proline isomerization by cyclophilin A lowers the energy

135 This study highlights how proline isomerization should be considered a critical qu

136 Proline, L-arginine, L-histidine, L-isoleucine, and tryp

137 etic rate correlated with trunk diameter and proline leaf ratio (T3/T1) significantly correlated with

138 dehydrogenase (PRODH) is activated to reduce proline levels by the chromatin remodeling factor lympho

139 enocarcinoma substantially reduces PYCR1 and proline levels, and diminishes fibrosis in vivo, resulti

140 unknown natural products with incorporated l-proline-like precursors and likely in the microbial cent

141 R1 complex that links mechano-environment to proline metabolism and signaling, and suggest a strategy

142 n metabolic pathways related to arginine and proline metabolism as well as TCA cycle was most promine

143 Many cancers alter their proline metabolism by up-regulating the proline cycle an

144 Reprograming of proline metabolism is critical for tumor growth.

145 y, flagella rotation to accumulate cells and proline metabolism to counteract oxidative stress, durin

146 evealed up-regulated AA metabolism, arginine/proline metabolism, and branched-chain AA (BCAA) metabol

147 Put7 of MCUR1 as regulators of mitochondrial proline metabolism.

148 cted role of MCUR1 homologs in mitochondrial proline metabolism.

149 nd liver had significant changes in arginine/proline metabolism; and the skeletal muscle and lung had

150 tide-thiourea catalyst features a N-terminal proline moiety for aldehyde activation and a thiourea un

151 0-gp41 disulfide [SOS] with an isoleucine-to-proline mutation [IP] in gp41) alone, as well as B41 and

152 that restriction of RSV G flexibility with a proline mutation abolishes binding to antibody 3G12 but

153 The crystal structure of the CTD with proline mutation L390P showed a flattening of the first

154 l C-terminus truncation (at residue 365) and proline mutation of this proximal region (H377P, L380P,

155 ing of the effects on protein stability from proline mutations and from charge-changing mutations.

156 Proline mutations decreased Ca(2+) activation for both C

157 Proline mutations in the alphaB helix greatly decreased

158 l-thiazolidine-2-carboxylate, and N-formyl l-proline (NFLP).

159 oly-P tracts, we found that, while the first proline of poly-P tracts adopts similar levels of cis co

160 iated mutations, isomerization of a critical proline, or alternative splicing are all sufficient to d

161 asma concentrations of glutamine, glutamate, proline, ornithine, citrulline, and arginine were signif

162 ceptibility owing to peptidyl methionine and proline oxidation as well as acetaldehyde adduct formati

163 al of four amino acid variants (leucine [L], proline [P], serine [S], and threonine [T]).

164 e highest color (a) and fructose, F/G ratio, proline, pH, conductivity, Fe, Cu, Al, and Mn values wer

165 cant in terms of color (L and a), F/G ratio, proline, pH, electrical conductivity, Pb, Cu, and Mn.

166 onal preferences of prolines present in poly proline (poly-P) homorepeats in their protein context.

167 Mutation of the hydroxylation acceptor proline precludes tyrosine autophosphorylation and foldi

168 igation of the conformational preferences of prolines present in poly proline (poly-P) homorepeats in

169 of glutamic acid (GLU), glutamine, glycine, proline (PRO), tryptophan (TRP), tyrosine, serine and GA

170 nd liposomal nanovesicles loading Isoleucine-Proline-Proline (IPP) as suitable ingredients of functio

171 conferred by mutation within a member of the proline-proline-glutamate (PPE) family, PPE51.

172 ell as Raman bands at 856 cm(-1) for hydroxy-proline (R = -0.68, p = 0.0056) and at 1032 cm(-1) for h

173 S-acylation, but extended and rigid alanine-proline repeats perturbed it.

174 Mutating a conserved proline residue (P63A) in the HUalpha subunit, deleting

175 SFMBT1 hydroxylation on Proline residue 651 by EglN1 mediated its ubiquitination

176 ous study of the effect of deleting a single proline residue in the FP of a demyelinating MHV strain,

177 alysis revealed that Ssu72 requires that the proline residue in the substrate's SP motif is in the ci

178 A proline residue located at the central FP region has oft

179 However, the proline residue of DYRK1 targeted by hydroxylation and t

180 ical amino acids were subsequently mapped to proline residues 184 and 188 within a conserved PXXXP mo

181 The optimal linker contains two proline residues and enhances compound affinity.

182 ation decreased by 125-fold with three added proline residues between tyrosine and the oxidant.

183 the MS2-derived protein cage with N-terminal proline residues followed by three variable positions.

184 usually resistant peptide bonds adjacent to proline residues in the 33-mer peptide.

185 strategy is reported for the modification of proline residues in the N-terminal positions of proteins

186 roach, we identified several surface-exposed proline residues in the nucleotide binding domain and li

187 ere, we report that deletion of one of these proline residues, resulting in RSA59 (P), significantly

188 post-translational hydroxylation of peptidyl proline residues.

189 onverting conformers that often contain many proline residues.

190 d to the same reading frame, adding a common proline rich C-terminal part instead of the last KH RNA

191 Sorghum glycine rich proline rich protein (SbGPRP1) exhibit antimicrobial pro

192 ns have strong binding affinity for the SOS1 proline-rich (PR) domain that mediates the Grb2-SOS1 int

193 ne-rich domain, the basic domain, and serine/proline-rich (SP-rich) domain.

194 locked TGFbeta-stimulated phosphorylation of proline-rich Akt substrate of 40 kDa (PRAS40), an intrin

195 We found that while the proline-rich and microtubule binding regions both contai

196 Proline-rich antimicrobial peptides (PrAMPs) are cationi

197 Proline-rich antimicrobial peptides (PrAMPs) are promisi

198 o interact directly with CypD via its acidic proline-rich C-terminus region and binding at the putati

199 tly decreases translation efficiency (TE) of proline-rich collagens in cardiac fibroblasts as well as

200 tein interaction domains that typically bind proline-rich disordered segments and are involved in cel

201 or fibril formation, the dynamic, C-terminal proline-rich domain (PRD) of huntingtin exon-1 makes up

202 Surprisingly, the proline-rich domain (PRD), not the microtubule binding d

203 orylation of Ser46 and are fine-tuned by the proline-rich domain (PRD).

204 Here we show that Scar/WAVE's proline-rich domain is polyphosphorylated after the comp

205 Finally, we report the primate-specific proline-rich domain to be dispensable for both HSP90 int

206 , a central disordered alanine-rich motif, a proline-rich domain, and a transactivation domain.

207 ing through the interaction of VGLUT1 second proline-rich domain, endophilinA1 and intersectin1.

208 trate that tau interacts with PTEN via tau's proline-rich domain.

209 Proline-rich domains (PRDs) are among the most prevalent

210 interactions between Src homology three and proline-rich domains of synaptic proteins.

211 h they exhibit beta-strand character and the proline-rich domains undergo large-amplitude anisotropic

212 fundamental new feature is a ~ 45 amino acid proline-rich extension in each monomer replacing the tip

213 and this increase required the intact, long, proline-rich extracellular S1-S2 linker of the Kv1.5 cha

214 Here, we show that the proline-rich homeodomain protein/hematopoietically expre

215 en the yeast Abp1p SH3 domain (AbpSH3) and a proline-rich IDP, ArkA.

216 Src homology 3 (SH3) domains bind proline-rich linear motifs in eukaryotes.

217 simulation, whereas occasional kinks in the proline-rich linker region cause an overall bend in the

218 urthermore, binding of PFN2 to NAA80 via the proline-rich loop promotes binding between the globular

219 NAA80 binds PFN2 through a proline-rich loop, deletion of which abrogates PFN2 bind

220 disordered regions in the N-terminus and the proline-rich loop, the latter of which is partly ordered

221 In vitro, one proline-rich motif was sufficient for 11-kDa to sustain

222 Mechanistically, the proline-rich motif-mediated interaction of PRR11 with th

223 Mutations of all three proline-rich motifs of 11-kDa abolished its capability t

224 t contains three tandem sequentially similar proline-rich motifs that compete for a single binding si

225 at are cross-linked by ZP1, a protein with a proline-rich N terminus.

226 Src homology 3 (SH3) protein domain to four proline-rich peptides.

227 odular protein structure that recognizes the proline-rich Pro-Pro-x-Tyr (PPxY) motif contained in spe

228 A proline-rich protein (PRP) family, composed of tandemly

229 o = 0.72, p = 0.02) and changes in levels of proline-rich protein and mucin 7 following capsaicin (rh

230 teract/precipitate salivary proteins, namely proline-rich proteins (PRPs).

231 A family of repetitive proline-rich proteins interact with acidic pectins and p

232 Immunoglobulin and proline-rich receptor-1 (IGPR-1) is a cell adhesion mole

233 he role of Tau's N-terminal domain (NTD) and proline-rich region (PRR) in regulating interactions of

234 ns a noncanonical WH2 domain and an upstream proline-rich region (PRR) that by themselves are suffici

235 minus, an increase in negative charge in the proline-rich region (PRR), and a decrease in positive ch

236 to the microtubule binding repeat 2 (R2) and proline-rich region 2 (PRR2) of tau.

237 Cleavage of these proteins in a proline-rich region between their N-terminal Src homolog

238 egions both contain polyP binding sites, the proline-rich region is a requisite for compaction of the

239 2, Thr205, Thr212, Thr217 and Thr231) in the proline-rich region of the N-terminal domain.

240 identified a mechanosensitive protein, small proline-rich repeat 3 (SPRR3), in vascular smooth muscle

241 of HyFatl affects actin organization through proline-rich repeats.

242 ever, protein-protein interactions involving proline-rich segments are notoriously difficult to addre

243 fication of TCR signals and is governed by a proline-rich sequence (PRS) in CD3e that binds to the fi

244 ort structural motif (PW-turn) embedded in a proline-rich sequence, whose interaction with the human

245 rs specifically and selectively addressing a proline-rich sequence-recognizing domain that is charact

246 (NT)), a polyglutamine (Q (n) ) tract, and a proline-rich sequence.

247 unctional analysis revealed that the altered proline-rich stretch determines several functional physi

248 Thus, the proline-rich stretch from the glycine receptor alpha1 su

249 A proline-rich stretch in this receptor domain forms a non

250 MS-based analysis methods, we show that the proline-rich stretch surrounding P366 mediates binding t

251 domain of endophilin also interacts with the proline-rich third intracellular loop (TIL) of various G

252 Mutation of proline-rich transmembrane protein 2 (PRRT2), a regulato

253 hesion kinase (FAK) family kinases - FAK and proline-rich tyrosine kinase (Pyk2).

254 if), CDC25 (cell division cycle 25), and PR (proline-rich) tail domains.

255 effects on the conformational properties of proline (ring pucker, cis/ trans isomerization) are intr

256 The proline rings occupied one of two states, while the heli

257 on to the synthesis of a 3,4-disubstituted l-proline scaffold.

258 amily amino acid transporter expression as a proline-scavenging programme to drive tumourigenesis.

259 The consensus proline sequence is shared by most CMGC kinases, and pro

260 Proline-serine-threonine phosphatase-interacting protein

261 drome and may be a curative option for other proline-serine-threonine phosphatase-interacting protein

262 mice, which carry a missense mutation in the proline-serine-threonine phosphatase-interacting protein

263 ns of cyclin L2 at serine residues preceding proline significantly stabilized cyclin L2 and increased

264 tially shallower dependence on the number of proline spacers compared to the analogous electron trans

265 ic acid (DOTA)-conjugated CCK2R ligands with proline substitution at different positions were synthes

266 ilized by a disulfide bond, an isoleucine-to-proline substitution at residue 559 and a truncation at

267 A helix-disrupting proline substitution within the putative alpha-helical m

268 on of HexaPro, a variant with six beneficial proline substitutions exhibiting higher expression than

269 Experiments with helix-breaking proline substitutions in peptides and in PCSK9 protein i

270 In turn, the enhanced synthesis of proline supports TGFbeta-induced production of matrix pr

271 ee delta-azaproline derivatives as potential proline surrogates.

272 ession of PYCR1 in PINCH-1 KO cells restores proline synthesis and cell proliferation, and suppresses

273 uctase 1 (PYCR1), resulting in inhibition of proline synthesis and cell proliferation.

274 y-induced defects on mitochondrial dynamics, proline synthesis and cell proliferation.

275 abolishes ECM stiffening-induced increase of proline synthesis and cell proliferation.

276 xpressed in lung adenocarcinoma and promotes proline synthesis through regulation of mitochondrial dy

277 pathways, including reductive carboxylation, proline synthesis, and cystine import.

278 R1 that regulates mitochondrial dynamics and proline synthesis, and suggest an attractive strategy fo

279 P1 expression and inhibits PYCR1 expression, proline synthesis, fibrosis and tumor growth.

280 xylate reductase 1 (PYCR1), a key enzyme for proline synthesis.

281 e cis/trans isomerization of the surrounding prolines that are CypA substrates and by substitutions c

282 ng Delta(1)-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H.

283 fied a relatively rare mutation leading to a proline to leucine substitution (P152L) in TP53 at the v

284 two clusters, only one of which involves the proline to threonine mutation, suggesting that the low s

285 We identified a proline to threonine substitution in Kasalath relative t

286 25 biotypes scored as R3 or R4 had the same proline-to-serine substitution at p106.

287 Stress-responsive genes such as proline transporter 2, NADP-dependent glyceraldehyde and

288 Secondary structures of beta-proline tripeptides in solution were determined using th

289 ycloaddition and structural features of beta-proline tripeptides.

290 the chromatin- and PcG-associated component, PROLINE-TRYPTOPHANE-TRYPTOPHANE-PROLINE INTERACTOR OF PO

291 ta complex that is stabilized by an aromatic proline-tyrosine interaction.

292 Put6 or Put7 exhibit a pronounced defect in proline utilization, which can be corrected by the heter

293 The caged proline was generated using the highly efficient 4-carbo

294 tylpyridine from the reaction of glucose and proline was investigated using the carbon module labelin

295 The mutation found, P542R (proline was replaced by arginine at aminoacid 542), affe

296 endogenous levels of abscisic acid (ABA) and proline were also reduced in stress-treated hss mutant.

297 ionally, we found that specific hydroxylated prolines were dispensable for protein stability but requ

298 own to be repressed whenever two consecutive prolines were present, in contrast to the presence of a

299 ion NMR data on the cis/trans equilibrium of prolines within the poly-P repeats of huntingtin exon 1,

300 ing linked to cis/trans isomerization at two prolines within the YPP motif in the CRD3 loop that exis