ライフサイエンスコーパス: proline-rich

1 onstrating that the PTP catalytic domain and Proline-rich 1 (P1) domain are respectively binding to t

2 ormula-fed infants at three CpGs in the gene proline rich 5 like (PRR5L) (p < 10(4)).

3 Here, we show that the synaptic component Proline rich 7 (PRR7) accumulates in the nucleus of hipp

4 We previously reported that synaptopodin, a proline-rich actin-binding protein, induces stress fibre

5 RC1 regulatory binding partners, the role of Proline Rich AKT Substrate of 40 kDa (PRAS40) in control

6 The proline-rich Akt (v-akt murine thymoma viral oncogene ho

7 d priming induced phosphorylation of AKT and proline-rich AKT substrate 40 kDa (PRAS 40), which in tu

8 in the same cells allowed us to identify the proline-rich Akt substrate of 40 kDa (PRAS40) as the uni

9 The proline-rich Akt substrate of 40 kDa (PRAS40) has recent

10 In contrast, expression of proline-rich Akt substrate of 40 kDa (PRAS40) inhibited

11 locked TGFbeta-stimulated phosphorylation of proline-rich Akt substrate of 40 kDa (PRAS40), an intrin

12 ecreases in mRNA levels were observed of the proline-rich anchor of AChE, PRiMA, no changes were seen

13 a bilayered mechanism of phosphotyrosine and proline-rich anchoring motifs.

14 ion enabled by an IIML motif embedded in its proline-rich and exceptionally long intercysteine loop 4

15 We found that while the proline-rich and microtubule binding regions both contai

16 s been well documented, the influence of the proline-rich and presumably disordered carboxy terminus

17 Bac7 is a proline-rich antimicrobial peptide, selective for Gram-n

18 Proline-rich antimicrobial peptides (PrAMPs) are cationi

19 Proline-rich antimicrobial peptides (PrAMPs) are instead

20 Proline-rich antimicrobial peptides (PrAMPs) are promisi

21 pidaecins, which refer to a series of small, proline-rich antimicrobial peptides, are predominantly a

22 ved the coverage of missing and particularly proline-rich areas of the proteome.

23 hat expression of a 17-amino acid N-terminal proline-rich attachment domain of collagen Q is sufficie

24 catalytic subunits, incubated with synthetic proline-rich attachment domain peptides containing the e

25 d to the same reading frame, adding a common proline rich C-terminal part instead of the last KH RNA

26 by PI31 are conferred by the HbYX-containing proline-rich C-terminal domain but do not require HbYX r

27 hat serves as its proteasome docking site; a proline-rich C-terminal hRpn2 extension stretches across

28 structurally divergent catalytic site and a proline-rich C-terminal subdomain suggest that this prot

29 e that the OCRE domain directly binds to the proline-rich C-terminal tail of the essential snRNP core

30 We identify the proline-rich C-terminus as a new domain of CE that is re

31 o interact directly with CypD via its acidic proline-rich C-terminus region and binding at the putati

32 Neither the proline-rich, C-terminal domain of aSyn nor the hydrolyt

33 entify four genes, ATP11C, IQCB1, TUBD1, and proline-rich coiled-coil 2C (PRRC2C), with a significant

34 tly decreases translation efficiency (TE) of proline-rich collagens in cardiac fibroblasts as well as

35 SH3 domains usually interact with a proline-rich consensus sequence, but the region of param

36 s and cavity size on catalytic efficiency of proline-rich cyclopeptoids under phase-transfer conditio

37 Moreover, IGPR-1, through its proline-rich cytoplasmic domain, associates with multipl

38 protein in the cytoplasm, N- and C-terminal proline-rich disordered regions, and a large 1,700-aa ce

39 tein interaction domains that typically bind proline-rich disordered segments and are involved in cel

40 A long, proline-rich, disulfide-bonded pigtail loop in TSR1 over

41 yloid fibril formation, while the C-terminal Proline Rich Domain destabilizes fibrils and enhances ol

42 omain are inessential, as are the C-terminal proline-rich domain (amino acids 382-476) and two zinc-b

43 e intramolecular interaction site within the proline-rich domain (PRD) of ALIX transforms cytosolic A

44 or fibril formation, the dynamic, C-terminal proline-rich domain (PRD) of huntingtin exon-1 makes up

45 containing 17 amino acids (N17), polyQ, and proline-rich domain (PRD)) become ordered at very differ

46 , a homolog of hPLSCR1 that lacks N-terminal proline-rich domain (PRD), did not show scramblase activ

47 Surprisingly, the proline-rich domain (PRD), not the microtubule binding d

48 tution of proline by arginine within the p53 proline-rich domain (PRD).

49 orylation of Ser46 and are fine-tuned by the proline-rich domain (PRD).

50 A series of peptides derived from the proline-rich domain (residues 174-251) of tau was synthe

51 esence of a C-terminal extension featuring a proline-rich domain and an actin-binding WASP-Homology 2

52 present a C-terminal extension containing a proline-rich domain and an actin-binding Wiskott-Aldrich

53 on of profilin-actin complexes with the VASP-proline-rich domain and the binding of the VASP-F-actin

54 e cytoplasmic C terminus of Kv3.3 contains a proline-rich domain conserved in proteins that activate

55 Its long C-terminal proline-rich domain contains 13 PXXP motifs, which orche

56 phospho- or phospho-mimetic mutations in the proline-rich domain eliminate the acceleration phase by

57 PEPD binds to the proline-rich domain in p53, which inhibits phosphorylati

58 Here we show that Scar/WAVE's proline-rich domain is polyphosphorylated after the comp

59 nd the cysteine-rich domain or intracellular proline-rich domain is required for Wnt5a-induced recrui

60 yeast two-hybrid screen that identified the proline-rich domain of ASPP2 as a host cellular target.

61 tivated AKT by forming a complex between the proline-rich domain of CKAP4 and the Src homology 3 doma

62 s between the C terminus of K(V)10.1 and the proline-rich domain of cortactin, regions targeted by ma

63 The carboxy-terminal proline-rich domain of DAZAP1 interacts with and neutral

64 clathrin-coated pits and interacted with the proline-rich domain of dynamin.

65 A human Kv3.3 mutation within a conserved proline-rich domain produces channels that bind Hax-1 bu

66 entral and the C-terminal end of the dynamin proline-rich domain that account for a significant incre

67 Finally, we report the primate-specific proline-rich domain to be dispensable for both HSP90 int

68 , a central disordered alanine-rich motif, a proline-rich domain, and a transactivation domain.

69 ing through the interaction of VGLUT1 second proline-rich domain, endophilinA1 and intersectin1.

70 ro-786-Pro-793) at the N-terminal end of the proline-rich domain, whereas the amphiphysin SH3 binds S

71 eucine-rich repeat, tropomodulin domain, and proline-rich domain-containing protein (RLTPR); moesin;

72 trate that tau interacts with PTEN via tau's proline-rich domain.

73 eviously unrecognized extended region of the proline-rich domain.

74 KD2 interacts with CIB1a via its alanine and proline-rich domain.

75 ssion of Bmf expression independent of p53's proline-rich domain.

76 as ZO-1's MAGUK domain and YAP's N-terminal proline-rich domain.

77 ing is mutually exclusive and dependent on a proline-rich domain.

78 Proline-rich domains (PRDs) are among the most prevalent

79 he affinity for Sec23 is concentrated in the proline-rich domains (PRDs) of TANGO1 and cTAGE5, but Se

80 phosphorylation sites within their specific proline-rich domains (PRDs) that are differentially regu

81 interactions between Src homology three and proline-rich domains of synaptic proteins.

82 The C-terminal, proline-rich domains of TANGO1 molecules in the ring are

83 the C-terminal domain of FAK containing the proline-rich domains PRR2 and PRR3.

84 h they exhibit beta-strand character and the proline-rich domains undergo large-amplitude anisotropic

85 recruitment through its own coiled coil and proline-rich domains.

86 tains a proline-rich (PR) domain termed PDP (Proline rich-DUF3587-Proline rich) that forms homo-oligo

87 Together, our findings indicate that the proline-rich exons are modular cassettes that convert WN

88 fundamental new feature is a ~ 45 amino acid proline-rich extension in each monomer replacing the tip

89 and this increase required the intact, long, proline-rich extracellular S1-S2 linker of the Kv1.5 cha

90 on and fibrillation of SAA, we truncated the proline-rich final 13 residues of SAA2.2.

91 and semi-rigid polyproline II helices in the proline-rich flanking domain (PRD).

92 e genes encoding a family of proteins termed proline-rich gamma-carboxyglutamic acid (PRRG) proteins

93 the transmembrane and cytoplasmic regions of proline-rich Gla protein 2.

94 nd a peptide comprised of PEMV CP fused to a proline-rich hinge (-P-) and green fluorescent protein (

95 poietically expressed homeodomain protein or proline-rich homeodomain protein (HHEX/PRH), which there

96 shown previously that phosphorylation of the Proline-Rich Homeodomain protein (PRH/Hhex) by CK2 inhib

97 PRH/HHex (proline-rich homeodomain protein) is a transcription fac

98 Here, we show that the proline-rich homeodomain protein/hematopoietically expre

99 en the yeast Abp1p SH3 domain (AbpSH3) and a proline-rich IDP, ArkA.

100 is pattern of amino acid usage is typical of proline-rich IDRs.

101 ants were located in a region that encodes a proline-rich, intrinsically disordered domain of the pro

102 ly induces STIM1 phosphorylation at Y361 via proline-rich kinase 2 (Pyk2) in ECs.

103 Unlike other EVH1 domains that interact with proline-rich ligands, the crystal structure of the Flfl

104 Src homology 3 (SH3) domains bind proline-rich linear motifs in eukaryotes.

105 simulation, whereas occasional kinks in the proline-rich linker region cause an overall bend in the

106 RDs contain repeated PPP motifs separated by proline-rich linkers, so a single TANGO1/cTAGE5 receptor

107 urthermore, binding of PFN2 to NAA80 via the proline-rich loop promotes binding between the globular

108 NAA80 binds PFN2 through a proline-rich loop, deletion of which abrogates PFN2 bind

109 disordered regions in the N-terminus and the proline-rich loop, the latter of which is partly ordered

110 found that BChE is anchored at the TSC by a proline-rich membrane anchor, the small transmembrane pr

111 of the Ena/VASP EVH1 domain with an extended proline rich motif in Abi.

112 ther bare or functionalized by mimicking the proline-rich motif (PRM) ligand (PPPVPPRR) and compare i

113 MP contains an N-terminal SH3 domain-binding proline-rich motif and forms a complex with the tyrosine

114 Individual prolines in the 6-residue proline-rich motif are highly tolerant of alanine substi

115 Although the prolines in the proline-rich motif do not directly interact with membran

116 Here we identify an atypical proline-rich motif in chimaerins that binds to the adapt

117 linker molecule that couples the C-terminal proline-rich motif of CD28 to the recruitment and activa

118 ats of TRPA1 directly bind to the C-terminal proline-rich motif of FGFR2 inducing the constitutive ac

119 able decoy peptide corresponding to the same proline-rich motif reduced SFK binding to WT GST-TRAF6 c

120 n consistence, in vivo during infection, one proline-rich motif was enough for 11-kDa to significantl

121 In vitro, one proline-rich motif was sufficient for 11-kDa to sustain

122 strate that SH3 (Src homology 3) domain-PRM (proline-rich motif) interactions involving multivalent l

123 Mechanistically, the proline-rich motif-mediated interaction of PRR11 with th

124 ein interactions mediated via its C-terminal proline-rich motif.

125 that phase-separates when mixed with a poly-proline-rich-motif (polyPRM) ligand.

126 0 regulator of kinase II (CrkII), recognizes proline-rich motifs (PRMs) of binding partners, such as

127 tion, using the pentamers of SH3 domains and proline-rich motifs (SH3(5) and PRM(5)) as droplet-formi

128 ybrid and pull-down experiments identify two proline-rich motifs in PakB-1-180 that directly interact

129 Mutations of all three proline-rich motifs of 11-kDa abolished its capability t

130 Src homology 3 (nSH3) domain of CrkII to the proline-rich motifs of cAbl (PRMs(cAbl)).

131 t contains three tandem sequentially similar proline-rich motifs that compete for a single binding si

132 s with Grb2 with high affinity through three proline-rich motifs, of which at least one is indispensa

133 at are cross-linked by ZP1, a protein with a proline-rich N terminus.

134 Most importantly, the large proline-rich N-terminal domain is not exposed to the ext

135 microvilli via a mechanism that requires its proline-rich N-terminus.

136 ly promoted initiation at AUG872, yielding a proline-rich oligopeptide.

137 ins, being particularly reactive towards the proline-rich ones.

138 ing to the kinase domain effects dynamics of proline-rich or phosphorylated peptide ligand binding si

139 leader of the mgtA mRNA contains a 17-codon, proline-rich ORF, mgtL, whose translation regulates the

140 n-binding site or its vicinity, the arm-like proline-rich (P-) domain of calreticulin contributes to

141 The proline rich peptide H-AP10CP10CP10-NH2 was site-directe

142 h amelogenin peptide (TRAP), and a synthetic proline-rich peptide (P2) on acute wound healing after a

143 Second, a proline-rich peptide in HD-PTP binds the SH3 domain of S

144 eby strongly inhibiting the interaction with proline-rich peptide ligands.

145 njugated with either one or two repeats of a proline-rich peptide to each arm (P1 or P2, respectively

146 s encoding human butyrylcholinesterase and a proline-rich peptide under elongation factor promoter co

147 for the interaction between the human saliva proline-rich peptides (IB714 and IB937) and procyanidins

148 xt was significant cis-trans isomerism, with proline-rich peptides containing aromatic residues exhib

149 alpha-amylase inhibitors are cysteine-rich, proline-rich peptides found in the Amaranthaceae and Apo

150 Proline-rich peptides have been shown to promote periodo

151 Similar proline-rich peptides on UBPY also bind STAM2 SH3 to fac

152 Undigested gliadin proline-rich peptides trigger the innate and adaptive im

153 ctures of the plant profilin in complex with proline-rich peptides.

154 Src homology 3 (SH3) protein domain to four proline-rich peptides.

155 f the Src homology 3 (SH3) domain with short proline-rich peptides.

156 p-interacting protein (WIP) is a 503-residue proline-rich polypeptide expressed in human T cells.

157 lass, nucleation is actively suppressed by a proline-rich polyQ segment covalently attached to htt(NT

158 Importantly, Bag6 contains a proline-rich (PR) domain termed PDP (Proline rich-DUF358

159 ns have strong binding affinity for the SOS1 proline-rich (PR) domain that mediates the Grb2-SOS1 int

160 ein reveal a distinct role of the C-terminal proline-rich (PR) domain to obstruct the engagement of a

161 n of the yeast protein Sho1 with its cognate proline-rich (PR) sequence of Pbs2.

162 odular protein structure that recognizes the proline-rich Pro-Pro-x-Tyr (PPxY) motif contained in spe

163 Sorghum glycine rich proline rich protein (SbGPRP1) exhibit antimicrobial pro

164 STAT3-driven expression of small proline rich protein 2a (SPRR2a), which acts as an src h

165 A proline-rich protein (PRP) family, composed of tandemly

166 unctional characterization of a glycine-rich proline-rich protein (SbGPRP1) from Sorghum which was pr

167 transcription of neuropeptide y (npy), small proline-rich protein 1a (sprr1a), and vasoactive intesti

168 o = 0.72, p = 0.02) and changes in levels of proline-rich protein and mucin 7 following capsaicin (rh

169 R14 and the mutants, our work uncovered this proline-rich protein as a novel activator of the PI3K pa

170 ochemical analysis revealed that PRR14, as a proline-rich protein, binds to the Src homology 3 (SH3)

171 Specifically, acidic proline-rich protein, cystatin, statherin and protein S1

172 kout cell envelope, in addition to the small proline rich proteins.

173 the interaction between a family of salivary proline-rich proteins (aPRPs) and representative pyranoa

174 tions between basic, glycosylated and acidic proline-rich proteins (bPRPS, gPRPs, aPRPs) and P-B pept

175 teract/precipitate salivary proteins, namely proline-rich proteins (PRPs).

176 ily old salivary proteins such as mucins and proline-rich proteins contain large regions of tandem re

177 A family of repetitive proline-rich proteins interact with acidic pectins and p

178 Prolamins are proline-rich proteins occurring in cereal grains.

179 the arabinogalactan proteins, extensins, and proline-rich proteins, in reality, a continuum of struct

180 nteracts with phosphoinositides and multiple proline-rich proteins, including the WAS protein (WASp)/

181 s and the expression of involucrin and small proline-rich proteins, which covalently bind ceramides.

182 omponents and processes such as histones and proline-rich proteins.

183 etail that RBP C-terminal SH3 domains bind a proline-rich (PxxP) motif of Aplip1/JIP1 with submicromo

184 Immunoglobulin and proline-rich receptor-1 (IGPR-1) is a cell adhesion mole

185 copy, we demonstrate that immunoglobulin and proline-rich receptor-1 (IGPR-1) responds to mechanical

186 identified the immunoglobulin-containing and proline-rich receptor-1 (IGPR-1, also called TMIGD2) gen

187 Although Ig-containing and proline-rich receptor-1(IGPR-1) was recently identified

188 d identify serine 986 (S986) within a serine-proline rich region of MED14 as the major ERK phosphoryl

189 he role of Tau's N-terminal domain (NTD) and proline-rich region (PRR) in regulating interactions of

190 ns a noncanonical WH2 domain and an upstream proline-rich region (PRR) that by themselves are suffici

191 dition to these WW domains, Itch possesses a proline-rich region (PRR) that has been shown to interac

192 Both ITK and LCK interact with TSAD's proline-rich region (PRR) through their Src homology 3 (

193 minus, an increase in negative charge in the proline-rich region (PRR), and a decrease in positive ch

194 o transactivation domains (TAD1 and TAD2), a proline-rich region (PRR), and multiple phosphorylation

195 ERK signaling by the concerted action of its proline-rich region (PRR), RhoGAP domain, and the BNIP-2

196 nding of a conserved PxRPxK motif within the proline-rich region 1 of THEMIS to the C-terminal SH3-do

197 orylation were mapped to a YY-motif close to proline-rich region 1.

198 we find that FAK activity and FAK C-terminal proline-rich region 2 (PRR2) and PRR3 are required for F

199 to the microtubule binding repeat 2 (R2) and proline-rich region 2 (PRR2) of tau.

200 The N-terminal of MyRF, which contains a proline-rich region and a DNA binding domain (DBD), is a

201 zes via two intermolecular interactions (SH3:proline-rich region and BH:BH) to selectively bind unpho

202 nt receptor potential subtype V1 (TRPV1) via Proline-rich region and regulates TRPV1 surface expressi

203 AVS and a truncated MAVS lacking part of the proline-rich region and the C-terminal transmembrane dom

204 Cleavage of these proteins in a proline-rich region between their N-terminal Src homolog

205 The proline-rich region contains two highly conserved aspara

206 o the P3 block ((396)PAIPPKKPRP(405)) of the proline-rich region in CIN85.

207 The first antibody, ADx201, binds the Tau proline-rich region independently of the phosphorylation

208 egions both contain polyP binding sites, the proline-rich region is a requisite for compaction of the

209 tion of at least one of five residues in the proline-rich region of tau.

210 2, Thr205, Thr212, Thr217 and Thr231) in the proline-rich region of the N-terminal domain.

211 lternatively spliced exons embedded within a proline-rich region of WNK1 that contain PY motifs, whic

212 rious sizes, sequences, and locations in the proline-rich region ofenv Outside theenvregion, all E-ML

213 ains two conserved cysteine-based domains, a proline-rich region, and a nuclear localization signal.

214 on at CME sites are the third EH domain, the proline-rich region, and the coiled-coil region.

215 are found within coiled-coil domains and the proline-rich region, motifs essential in other fusion sy

216 quences of ankyrin repeat-, SH3 domain-, and proline-rich region-containing protein 2 (ASPP2), a hapl

217 tein-protein interactions via the N-terminal proline-rich region.

218 the microtubule-binding domain and upstream proline-rich region.

219 optosis-linked gene-2 (ALG-2) and the Sec31A proline-rich region: 1) targeted disruption of ALG-2/Sec

220 (VRA and VRB, respectively), to include the proline rich-region (PRR) of SU.

221 th compaction of the microtubule binding and proline- rich regions.

222 posed of 2 N-terminal domains (N1 and N2), 2 proline-rich regions (PRR1 and PRR2) that flank a histid

223 identified as a GLK-interacting protein; two proline-rich regions of GLK and the WW domain of IQGAP1

224 of nebulin and nebulette as novel ligands of proline-rich regions of Xin and XIRP2.

225 identified a mechanosensitive protein, small proline-rich repeat 3 (SPRR3), in vascular smooth muscle

226 Interestingly, a deletion in a proline-rich repeat region (amino acids 274 to 289) of E

227 of HyFatl affects actin organization through proline-rich repeats.

228 ohydrate binding module revealed a short and proline-rich rigid linker that anchored together the cat

229 tein-tyrosine kinase Fyn, which binds to the proline-rich RTPPKSP motif conserved in both MAP2 and ta

230 crotubule (MT)-binding domain and the serine-proline-rich (S/P-rich) region of DCXs in-cis in the sam

231 MTC28 is a 28-kDa proline-rich secretary antigen of Mycobacterium tubercul

232 egment of consecutive glutamines (QN), and a proline-rich segment.

233 ever, protein-protein interactions involving proline-rich segments are notoriously difficult to addre

234 -homology 3 (SH3) domains that bind multiple proline-rich segments in the actin regulatory protein ne

235 s include domains specialized in recognizing proline-rich segments, including Src-homology 3 (SH3), W

236 well as the impact of the polyglutamine and proline-rich segments, remains, however, mostly uncharac

237 fication of TCR signals and is governed by a proline-rich sequence (PRS) in CD3e that binds to the fi

238 ibly recruited through its SH3.1 domain to a proline-rich sequence (PRS) in CD3epsilon after TCR enga

239 ted through its src homology 3.1 domain to a proline-rich sequence (PRS) in CD3epsilon.

240 ubunits to expose the CD3epsilon cytoplasmic proline-rich sequence (PRS).

241 g repeats, and a weaker interaction with the proline-rich sequence and the termini of tau.

242 with quantitative differences in CD3epsilon proline-rich sequence exposure and Nck recruitment.

243 at this characteristic of HOXB4 depends on a proline-rich sequence near the N terminus, which is uniq

244 The SdpI-binding site was mapped to a proline-rich sequence of 22 amino acids within the intra

245 is N-terminal subdomain of CagA with a 7-kDa proline-rich sequence of ASPP2 reveals that this domain

246 2 (WH2) domain that binds actin, and (ii) a proline-rich sequence that binds profilin-actin complexe

247 In mammals, VGLUT1 gained a proline-rich sequence that recruits endophilinA1 and tur

248 A proline-rich sequence within VP1/2 is required for the e

249 ort structural motif (PW-turn) embedded in a proline-rich sequence, whose interaction with the human

250 rs specifically and selectively addressing a proline-rich sequence-recognizing domain that is charact

251 tory domains, and its FH1 domain has minimal proline-rich sequence.

252 h a selectivity filter formed by an uncommon proline-rich sequence.

253 (NT)), a polyglutamine (Q (n) ) tract, and a proline-rich sequence.

254 elongation, but in the presence of profilin, proline-rich sequences are required to support polymeras

255 In between NRD and CRD, proline-rich sequences mediate the incorporation of prof

256 d that different SH3 domains target distinct proline-rich sequences overlapping significantly.

257 Collaboration between WH2 and proline-rich sequences thus strikes a balance between fi

258 s by its SH3 domain, which bound directly to proline-rich sequences within EspF(U).

259 ctions and acting through the recognition of proline-rich sequences.

260 tion relies on the integrity of a C-terminal proline-rich SH3 binding region of M2 and its interactio

261 ne-rich domain, the basic domain, and serine/proline-rich (SP-rich) domain.

262 audin-1, a tight junction protein, and small proline-rich (Sprr2) protein, a major component of corni

263 Together, these data indicate that the proline-rich Src homology 3 domain-binding motif in TRAF

264 repeat (TSR) domains in TRAP connect through proline-rich stalk, transmembrane, and cytoplasmic domai

265 ic stretch (N17) and a C-terminal 38-residue proline-rich stretch (C38).

266 unctional analysis revealed that the altered proline-rich stretch determines several functional physi

267 Thus, the proline-rich stretch from the glycine receptor alpha1 su

268 A proline-rich stretch in this receptor domain forms a non

269 MS-based analysis methods, we show that the proline-rich stretch surrounding P366 mediates binding t

270 These results indicate that proline-rich stretches attenuate the potential of stem c

271 if), CDC25 (cell division cycle 25), and PR (proline-rich) tail domains.

272 (PR) domain termed PDP (Proline rich-DUF3587-Proline rich) that forms homo-oligomer, allowing the UBL

273 Because the region is proline rich, the hypothesis that it targets Src homolog

274 domain of endophilin also interacts with the proline-rich third intracellular loop (TIL) of various G

275 elated protein SynDIG4 [also known as Prrt1 (proline-rich transmembrane protein 1)] has recently been

276 Proline-rich transmembrane protein 2 (PRRT2) has been id

277 Proline-Rich Transmembrane Protein 2 (PRRT2) has been sh

278 Mutation of proline-rich transmembrane protein 2 (PRRT2), a regulato

279 PRRT2 (proline-rich transmembrane protein 2 gene) has been iden

280 ncing has identified mutations in the PRRT2 (proline-rich transmembrane protein 2) gene as the leadin

281 hesion kinase (FAK) family kinases - FAK and proline-rich tyrosine kinase (Pyk2).

282 transducer) was mediated by FA formation and proline-rich tyrosine kinase 2 (PYK2) activity.

283 In cultured cells, phosphorylation of a FAK/proline-rich tyrosine kinase 2 (PYK2) consensus site in

284 Despite the involvement of proline-rich tyrosine kinase 2 (Pyk2) in endothelial cel

285 Proline-rich tyrosine kinase 2 (Pyk2) is a member of the

286 Proline-rich tyrosine kinase 2 (Pyk2) is activated by va

287 results reveal that tyrosine kinases Src and proline-rich tyrosine kinase 2 (Pyk2) regulate SHP-1-dep

288 Proline-rich tyrosine kinase 2 (PYK2), a redox-sensitive

289 to-oncogene tyrosine-protein kinase) and the proline-rich tyrosine kinase 2 (Pyk2), and they can also

290 actin as a novel substrate and interactor of proline-rich tyrosine kinase 2 (Pyk2).

291 erentiation primary response gene-88 (MYD88)/proline-rich tyrosine kinase 2 (PYK2)/LYN complexes, whi

292 Inhibition of proline-rich tyrosine kinase 2 improved insulin-induced

293 dies showed that inhibition of both FAK1 and proline-rich tyrosine kinase 2 partially restored integr

294 Inhibition of proline-rich tyrosine kinase 2 restores insulin-induced

295 itory residue Y657 of eNOS and expression of proline-rich tyrosine kinase 2 that phosphorylates this

296 DPH oxidase, Syk, focal adhesion kinase, and proline-rich tyrosine kinase 2, and in the absence of De

297 Proline-rich tyrosine kinase 2, in turn, caused activati

298 and Syk that activated the downstream kinase proline-rich tyrosine kinase 2.

299 lying this process: a phospholipase C/Ca(2+)/proline-rich tyrosine kinase 2/cJun N-terminal kinase pa

300 Aldosterone infusion increased proline-rich WNK1 isoform abundance in WT mice but did n