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1 physically associates with Sjl2 through its proline-rich domain.
2 as ZO-1's MAGUK domain and YAP's N-terminal proline-rich domain.
3 hatase domain, a 5-phosphatase domain, and a proline-rich domain.
4 ing is mutually exclusive and dependent on a proline-rich domain.
5 mily kinases (Src or Hck) via its C-terminal proline-rich domain.
6 al LIM domains, but one lacks the N-terminal proline-rich domain.
7 erminal acidic and conserved PR motif or the proline-rich domain.
8 of the Cdc42 binding domain but required the proline-rich domain.
9 binding to an amino-terminal region near the proline-rich domain.
10 trate that tau interacts with PTEN via tau's proline-rich domain.
11 apoptosis in p53 have been mapped, e.g., the proline-rich domain.
12 es mainly on 69 amino acids within Blimp-1's proline-rich domain.
13 calmodulin, as well as, the presence of its proline-rich domain.
14 the role of its unique, conserved histidine-proline-rich domain.
15 pleckstrin homology domain, and a C-terminal proline-rich domain.
16 l protein paxillin through its COOH-terminal proline-rich domain.
17 hown to bind directly through the C-terminal proline-rich domain.
18 he amino-terminal segment of hDlg containing proline-rich domain.
19 hSOS1 in vitro within the carboxyl-terminal proline-rich domain.
20 transmembrane segment, and an intracellular proline-rich domain.
21 rminal domains of CR, but not by the central proline-rich domain.
22 nsus SH2 binding sites, an SH3 domain, and a proline-rich domain.
23 nd basic domains of Tat, but not against the proline-rich domain.
24 cludes all microtubule-binding repeats and a proline-rich domain.
25 mediated by the amyloidogenic portion of its proline-rich domain.
26 eviously unrecognized extended region of the proline-rich domain.
27 KD2 interacts with CIB1a via its alanine and proline-rich domain.
28 ssion of Bmf expression independent of p53's proline-rich domain.
29 phosphorylation within the C-terminal serine/proline-rich domain.
30 s) of, or protein interactions with, the p63 proline-rich domain.
31 wo phosphoinositol phosphatase domains and a proline-rich domain.
32 nal domain, and a previously uncharacterized proline-rich domain.
33 he N-terminal Bro1 domain and the C-terminal proline-rich domain.
34 e L104PPPPP site located within the migfilin proline-rich domain.
35 ne-rich, interleukin-1 receptor-related, and proline-rich domains.
36 shown to bind known proteins that contained proline-rich domains.
37 recruitment through its own coiled coil and proline-rich domains.
38 with a C2H2-type zinc finger motif, a serine/proline-rich domain, a basic domain, and a leucine-zippe
39 ar structure consisting of an NH(2)-terminal proline-rich domain, a central region of homology specif
40 s four distinct domains: a signal peptide, a proline-rich domain, a histidine-rich basic domain and a
41 cysteine-rich domains interspersed by eight proline-rich domains; a glycine- and serine-rich domain
43 n activation domains 1-2 and deletion of the proline-rich domain abolish mutant p53 to regulate Gro1
45 omain are inessential, as are the C-terminal proline-rich domain (amino acids 382-476) and two zinc-b
48 d C-terminal sequence including an extensive proline-rich domain and a C-terminal amphipathic helix.
49 ved leader peptide followed by an N-terminal proline-rich domain and a C-terminal cysteine-rich domai
50 acid nuclear protein with an amino-terminal proline-rich domain and a carboxyl-terminal DNA binding
52 p process, with recruitment dependent on the proline-rich domain and activation dependent on binding
54 esence of a C-terminal extension featuring a proline-rich domain and an actin-binding WASP-Homology 2
55 present a C-terminal extension containing a proline-rich domain and an actin-binding Wiskott-Aldrich
56 sactivation functions but required an intact proline-rich domain and direct DNA binding, providing me
57 synthesized peptide based on the functional proline-rich domain and examined its biological function
58 To further delineate the function of the proline-rich domain and its potential role in transactiv
59 on of profilin-actin complexes with the VASP-proline-rich domain and the binding of the VASP-F-actin
60 p53-(DeltaPRDDeltaBD), which lacks both the proline-rich domain and the C-terminal basic domain, are
61 ional analysis demonstrates that the central proline-rich domain and the C-terminal domain of ADAP ar
63 ished that Bro1 binds to hyperphosphorylated proline-rich domain and to analogs of late endosomal mem
65 STEP(61) binds to Fyn through one of its proline-rich domains and the kinase-interacting motif do
66 ases, possesses an N-terminal BRCT domain, a proline-rich domain, and a C-terminal polymerase beta-li
67 c domain with three key tyrosines, a central proline-rich domain, and a C-terminal Src homology 2 dom
68 near the N terminus followed by a repetitive proline-rich domain, and a cysteine-rich C-terminal PAC
71 those of Rho-specific GEFs, a PDZ domain, a proline-rich domain, and an area of homology to Lsc, p11
72 ncluding the phosphotyrosine-binding domain, proline-rich domain, and motifs containing phosphotyrosi
73 p53, the SH3 domain of which binds the WAVE2 proline-rich domain, and PIR121/Sra-1, which forms a pen
74 n domains of MTF1, namely the acidic domain, proline-rich domain, and serine-threonine rich domain, a
75 s, such as the second activation domain, the proline-rich domain, and the C-terminal basic domain, ar
76 ons, contains two transmembrane domains, two proline-rich domains, and a kinase-interacting motif.
77 so found that activation domains 1-2 and the proline-rich domain are required for mutant p53 gain of
78 conformational changes in the head, tail and proline-rich domains are linked structurally and thermod
79 ation domain 1, activation domain 2, and the proline-rich domain), are required for inducing cell cyc
80 usceptibility gene 1 C-terminal domain and a proline-rich domain at its N-terminus, we used a mass sp
81 h RING finger B-box-1 (PML-prb-), the serine-proline-rich domain at the C-terminal (PMLsp-), and the
83 ls-), the dimerization domain (PMLdim-), the proline-rich domain at the N-terminal (PMLpro-), the pro
84 was absent, as expected, due to removal of a proline-rich domain between amino acids 151-160 that is
86 n has a unique 120-amino acid glutamine- and proline-rich domain between the SH2 and C-terminal SH3 d
87 e C-terminal fragment, although having three proline-rich domains, bound to Grb2 and Crk less efficie
88 lization to the cell membrane, requiring the proline-rich domain, but not on the Src homology 2 domai
89 sphatidylinositol 3-kinase/AKT, required the proline-rich domains, but not the ZNF domains, of ZNF198
90 ing mutations in the IQ, TH-1-like, SH3, and proline-rich domains by frameshift or in-frame deletions
92 protein with a pleckstrin homology (PH) and proline-rich domain, by interaction with the MBC SH3 dom
94 e further demonstrate that the non-enzymatic proline-rich domain confers the increase in fidelity of
95 e cytoplasmic C terminus of Kv3.3 contains a proline-rich domain conserved in proteins that activate
97 eucine-rich repeat, tropomodulin domain, and proline-rich domain-containing protein (RLTPR); moesin;
99 tant (delta pro AE), which lacks this entire proline-rich domain (deleted for amino acids 62-91), was
101 he p53 point mutation L22Q/W23S, but not the proline-rich domain deletion mutants 83-393 and DeltaPro
102 ation of Abp1 with GST fusion of the dyanmin proline-rich domain demonstrate the interaction of Abp1
103 Bax to promote MDA-mediated cell death in a proline-rich domain-dependent manner through both transc
105 yloid fibril formation, while the C-terminal Proline Rich Domain destabilizes fibrils and enhances ol
108 MDM2 binding site, ATM phosphorylation site, proline rich domain, DNA binding domains (DBDs) II-V, nu
109 o DNA damage, indicating that removal of the proline-rich domain does not disrupt p53's upstream regu
110 3 (SH3) domain of c-SRC, but deletion of the proline-rich domain does not totally ablate the interact
111 h the p85 subunit of PI 3-kinase through its proline-rich domain during virus internalization and exp
112 s through a selective influence of the dyn-2 proline-rich domain (dyn-2 PRD) on the eNOS reductase do
113 phospho- or phospho-mimetic mutations in the proline-rich domain eliminate the acceleration phase by
115 ing through the interaction of VGLUT1 second proline-rich domain, endophilinA1 and intersectin1.
116 s of FcmuR deletion mutants, we identified a proline-rich domain essential for cell surface expressio
117 namin localization to the tails required its proline-rich domain, expression of a dynamin mutant lack
119 lts suggest that activation domain 2 and the proline-rich domain form an activation domain for induci
120 horylates primarily serine 857 (S857) in the proline-rich domain, found only in 1xa, one of the alter
121 ASP homology 2 domain and a profilin-binding proline-rich domain from espin did not decrease lengthen
122 adhesion targeting (FAT) sequence and second proline-rich domain from the tyrosine kinase domain and
125 On the other hand, this deletion of the p53 proline-rich domain impairs p53's ability to suppress tu
126 clude that a functional peptide derived from proline-rich domain in DOC-2/DAB2 has growth-inhibitory
130 W domains in the splicing factor PRP40 and a proline-rich domain in the branchpoint binding protein,
132 ot required for Duox function, mutation of a proline-rich domain in the Duox C terminus, a potential
133 oning of GPVI has revealed the presence of a proline-rich domain in the sequence of GPVI cytoplasmic
135 Our results demonstrate use of the WW and proline-rich domains in protein-engineered materials and
144 nd the cysteine-rich domain or intracellular proline-rich domain is required for Wnt5a-induced recrui
146 ent of alternating cysteine-rich domains and proline-rich domains is strikingly similar to that found
148 aying different patterns of MAP2 regulation: proline-rich domain mutants T293E and T300E impaired MT
149 a novel 374 amino acid protein containing a proline-rich domain near its N terminus and two LIM doma
150 or the Src family of tyrosine kinases, and a proline-rich domain near the C terminus that contains mu
155 nce and circular dichroism spectroscopy, the proline-rich domain of ALIX, which encodes binding epito
156 with simulations suggest that the N-terminal proline-rich domain of apoA-I influences the stability o
157 yeast two-hybrid screen that identified the proline-rich domain of ASPP2 as a host cellular target.
162 tivated AKT by forming a complex between the proline-rich domain of CKAP4 and the Src homology 3 doma
163 s between the C terminus of K(V)10.1 and the proline-rich domain of cortactin, regions targeted by ma
166 In this study, we further showed that the proline-rich domain of DOC-2/DAB2 could also interact wi
167 -specific peptides, we found that the second proline-rich domain of DOC-2/DAB2 is the key binding sit
170 of two mutations, either of which alters the proline-rich domain of Gag and is sufficient to confer d
171 in ER-accumulating domain) is the N-terminal proline-rich domain of gamma-zein that is sufficient to
172 ly, and the presence of the novel C-terminal proline-rich domain of GluR3salpha imparts lateral membr
176 Ubc9-depleted cell lines indicated that the proline-rich domain of HMGA1b positively influences tran
177 nd C-terminal domains, but not the histidine-proline-rich domain of HPRG, also bound plasminogen and
178 Htt, and Happ1, an intrabody recognizing the proline-rich domain of Htt, both reduce mHtt-induced tox
179 This activity requires a Src-kinase-binding proline-rich domain of Nef and a conserved tyrosine-base
185 ition was conferred by the carboxyl-terminal proline-rich domain of PI31, which appears to have an ex
187 of a peptide derived from the COOH-terminal proline-rich domain of PTP HSCF revealed that a subset o
188 placing two critical proline residues in the proline-rich domain of PTP1B between amino acids 301 and
190 talytically deficient mutant of SHIP2 or the proline-rich domain of SHIP2 enhanced Akt activation.
191 cond gene-trapped line, in which most of the proline-rich domain of Ssdp1 is retained, did not show a
192 interactions occur via two NPF motifs in the proline-rich domain of stonin 2 and Eps15 homology domai
193 he 5TAF core-interacting TAF8 domain and the proline-rich domain of TAF8 that interacts with TAF2 are
196 29 and 53 of Zta, containing homology to the proline-rich domain of the tumor suppressor protein p53.
197 ng was not due to an interaction between the proline-rich domain of WASP and the SH3 domain of these
198 -hybrid assay showed that the NH(2)-terminal proline-rich domain of Zimp7 and the region spanning ami
204 icted Wasp homology 2 (WH2) domains, and two proline-rich domains, one with similarity to eukaryotic
205 s more than directly activating Arp2/3, with proline-rich domains playing a central role in promoting
206 e transcriptional activation domain, the p53 proline-rich domain plays a critical role in the transmi
207 pTalpha cytoplasmic tail, in particular the proline-rich domain, plays a crucial role in pre-TCR sig
208 TD) I and II and binds to the polyQ-adjacent proline rich domain (PRD) of soluble as well as aggregat
209 Moreover, our recent study showed that the proline rich domain (PRD) of WAVE3 is required for maint
210 d antibody-based experiments revealed that a proline-rich domain (PRD) adjacent to the polyQ tract is
211 ic scaffold Pan1 contains an uncharacterized proline-rich domain (PRD) at its carboxy (C)-terminus.
213 entanglement and dynamics of the C-terminal proline-rich domain (PRD) in a mechanism analogous to po
214 l modification site or of the downstream MTS proline-rich domain (PRD) increased mitochondrial import
215 expression of p130(CAS) containing a deleted proline-rich domain (PRD) inhibited adenovirus cell entr
216 the mutant Dyn2 protein, indicating that the proline-rich domain (PRD) is required for Dyn2 recruitme
217 e intramolecular interaction site within the proline-rich domain (PRD) of ALIX transforms cytosolic A
219 or fibril formation, the dynamic, C-terminal proline-rich domain (PRD) of huntingtin exon-1 makes up
221 PVI receptor utilizes a unique intracellular proline-rich domain (PRD) to accelerate platelet activat
223 t protein and lipid interactions between its proline-rich domain (PRD) with SRC Homology 3 (SH3) doma
224 mediated in part through association of its proline-rich domain (PRD) with the Src homology 3 (SH3)
225 containing 17 amino acids (N17), polyQ, and proline-rich domain (PRD)) become ordered at very differ
226 e tandem activation domains (AD1 and AD2), a proline-rich domain (PRD), and a C-terminal basic domain
227 a PTAP mutant also depends on its C-terminal proline-rich domain (PRD), but not on the binding sites
228 , a homolog of hPLSCR1 that lacks N-terminal proline-rich domain (PRD), did not show scramblase activ
231 by a second mutation in the carboxy-terminal proline-rich domain (PRD), one that prevents dynamin fro
237 he affinity for Sec23 is concentrated in the proline-rich domains (PRDs) of TANGO1 and cTAGE5, but Se
238 phosphorylation sites within their specific proline-rich domains (PRDs) that are differentially regu
241 A human Kv3.3 mutation within a conserved proline-rich domain produces channels that bind Hax-1 bu
245 he activation domain (residues 1-59) and the proline-rich domain (residues 67-127) are required for T
246 of either the COOH-terminal actin binding or proline-rich domains resulted in enhanced adhesion and c
247 d serine-rich domain and at least one of the proline-rich domains show sequence similarity to protein
248 H2-type zinc fingers, and glutamine-rich and proline-rich domains, suggesting that it functions as a
250 entral and the C-terminal end of the dynamin proline-rich domain that account for a significant incre
251 ddition, the hDlg contains an amino-terminal proline-rich domain that is absent in other MAGUKs.
252 utants define discrete subregions of a novel proline-rich domain that is required for subcellular loc
254 talytic RING finger domain, and a C-terminal proline-rich domain that mediates interactions with Src
255 DHR1 and DHR2 (or "Docker"), and C-terminal proline-rich domains that associate with the adapter pro
257 Finally, we report the primate-specific proline-rich domain to be dispensable for both HSP90 int
258 the N-terminal SH2 domain and the C-terminal proline-rich domain to mediate its inhibitory effect.
262 s only the amino-terminal Q and glycine- and proline-rich domains typical of the Groucho/AES subfamil
263 h they exhibit beta-strand character and the proline-rich domains undergo large-amplitude anisotropic
264 two proteins requires both a TRPV4-specific proline-rich domain upstream of the ankyrin repeats of t
267 e loss of function seen with deletion of the proline-rich domain was not due to a DNA-binding defect,
269 hin a TPXK cdk5 phosphorylation motif in the proline-rich domain) was not affected by cdk5 phosphoryl
271 ro-786-Pro-793) at the N-terminal end of the proline-rich domain, whereas the amphiphysin SH3 binds S
272 N-terminal p53 fragment (transactivation and proline-rich domains), which induces apoptosis in non-ne
273 ngly, the pleckstrin homology domain and the proline-rich domain, which are known to bind to coated-p
274 g conditions releases the central, histidine-proline-rich domain, which contains 15 tandem repeats of
277 ipeptide sequence, adjacent to the conserved proline-rich domain, which was potentially a key differe
278 LNK recruitment was dependent upon the Grap2 proline-rich domain, while modulation of phosphorylation
279 -binding functions: an N-terminal serine and proline-rich domain with a predicted immunoglobulin-like
281 domains, two highly charged regions, and two proline-rich domains with multiple PPXY and PXXP motifs.
284 basic domain within residues 364-393 and the proline-rich domain within residues 64-91 are required f