ライフサイエンスコーパス: prolong

1 the effect of acute (perfusion only) versus prolonged (2 weeks pre-treatment plus perfusion) UDCA ad

2 wise, Keap1(f/f) pups were protected against prolonged (96 h) hyperoxia-induced hypoalveolarization.

3 has been challenging, however, to study the prolonged absence of NMDARs in vertebrates, and hence th

4 the role of the DH in cocaine seeking during prolonged abstinence has not been investigated.

5 R67Q(+/-) myocytes (n=5) demonstrated prolonged action potential duration at 90% repolarizatio

6 ompared with nonfailing hMSCs, failing hMSCs prolonged action potential duration by 24% (P<0.001, n=1

7 tory cortical neurons from both patients had prolonged action potential repolarization.

8 influx, generating a late Na(+) current that prolongs action potential duration (APD) and triggering

9 nel at the plasma membrane of cardiomyocytes prolongs action potential repolarization, which associat

10 ient-days) were all higher in the setting of prolonged acute mechanical ventilation than short-term m

11 Prolonged admissions to an ICU are associated with high

12 luding a subset of patients with evidence of prolonged AID activity during the pre-malignant phase, i

13 the naturally developed competent state was prolonged and persistent during pneumonia-derived sepsis

14 composition of the AM population to provide prolonged antibacterial protection.

15 ions of endemicity, where treatment requires prolonged antibiotic therapy.

16 ty (25%) of these cases were treated with QT-prolonging antimicrobials.

17 In mice, hybrid 7 produced significant and prolonged antinociception (up to 8 h), as compared to th

18 Reductive stress, as caused by prolonged antioxidant signaling or mitochondrial inactiv

19 Prolonged ART may restore the richness of the microbiota

20 al therapy was significantly associated with prolonged bacteremia and worse outcomes.

21 t only provided immobilization of BMP-2 with prolonged bioavailability, but also enhanced the attachm

22 Gpr56 (-/-) mice have prolonged bleeding, defective platelet plug formation, a

23 >50% of mature DG granule cells (GCs) or by prolonged brain-specific VEGF overexpression culminating

24 tive during NMP, which could be enhanced and prolonged by URC.

25 Therefore, how pressure produces a prolonged calcium elevation necessary to induce pancreat

26 eprogramming at >1400 sites in neurons after prolonged cannabinoid exposure.

27 STICK-NPs exhibit prolonged circulation time (17-fold higher area under cu

28 herapies, including improved solubilization, prolonged circulation, reduced toxicity, sustained relea

29 all-molecule ERBB inhibitor lapatinib led to prolonged clinical benefit and a lasting radiographic an

30 a mean graft survival of 35.3 days which was prolonged compared with PRCL-02 monotherapy but not comp

31 d in porous structure, which in turn ensured prolonged contact time of contaminated water with the ma

32 ce and shows high photostability, permitting prolonged continuous imaging.

33 This can permit prolonged control of tumors through intermittent dosing.

34 erbations and stepped down after a period of prolonged control.

35 rons alone is inefficacious but enhances and prolongs courtship or aggression promoted by female cues

36 Prolonged CPX tissue persistence, attributed to slower r

37 itive value, initiating high selectivity and prolonged cravings for drug through reward learning.

38 le and potentially preventable predictors of prolonged critical illness and prolonged critical illnes

39 als each had lower- and higher-than-expected prolonged critical illness frequency.

40 perative factors), whereas only one of eight prolonged critical illness mortality predictors was nonm

41 predictors of prolonged critical illness and prolonged critical illness mortality, and understand the

42 Approximately 40% of the prolonged critical illness predictors were nonmodifiable

43 Case-mix-adjusted prolonged critical illness rates were compared across ho

44 We aimed to define prolonged critical illness, delineate between nonmodifia

45 nd understand the interhospital variation in prolonged critical illness.

46 The upregulation of hapR resulted in a prolonged culturable state of V. cholerae in artificial

47 Prolonged culture also revealed that purified subpopulat

48 After prolonged cycling, the TMs displayed different levels of

49 t disease in two patients (10%), and grade 4 prolonged cytopenia in six patients (32%).

50 most resilient plants, and some can survive prolonged desiccation in semiarid regions with seasonal

51 whereas newborn neurons of the vDG showed a prolonged differentiation, migration, and maturation.

52 onent-shared alterations (trunk-ratio) had a prolonged disease-free survival (DFS), regardless of the

53 Under prolonged drought and reduced photosynthesis, plants con

54 The evidence indicates a prolonged drought in the likely western source region fo

55 equent concomitant treatment with several QT-prolonging drugs.

56 group of human organ donors characterized by prolonged duration of stay in an intensive care unit (IC

57 imer's disease (AD) are required in order to prolong effective and healthy memory and thinking capabi

58 Tracheostomy is often performed for prolonged endotracheal intubation in critically ill pati

59 ost assays require high bacterial burdens or prolonged enrichment to achieve acceptable performance.

60 btropic regions during the past decade and a prolonged episode of intermittently bloody diarrhea duri

61 nd preventing epithelial regeneration, which prolongs epithelial barrier impairment and creates an en

62 cer pathogenesis, suggesting a mechanism for prolonged epithelioid tumor cell survival.

63 Prolonged ER stress has been known to be one of the majo

64 theories of peace of citizens embroiled in a prolonged ethnonational conflict.

65 added to standard LMB chemotherapy markedly prolonged event-free survival and overall survival among

66 t the effectiveness of retreatment for these prolonged events.

67 lti-dimensional NMR experiments that require prolonged experiment times.

68 nselective cation channel; while repeated or prolonged exposure induces formation of a transmembrane

69 rticipated in a randomized clinical trial of prolonged exposure therapy (n = 36) versus treatment wai

70 During prolonged exposure to Ags, such as chronic viral infecti

71 whether thermophilic endospores can survive prolonged exposure to high temperatures, sediments were

72 Prolonged exposure to hyperoxia has deleterious effects

73 and PG production of porcine IVD cells under prolonged exposure to hypoxia with physiological glucose

74 ined a new severity category (level IV) with prolonged exposure to supplemental O2 (>=120 days) that

75 pounds, this shift occurred spontaneously on prolonged exposure to the Lewis acidic reaction conditio

76 g and implementing the aftereffect following prolonged exposure.

77 temporal transcription factor manipulations-prolonging expression of Hunchback in NB3-1, as well as

78 a series of half-blinks followed by either a prolonged eye narrow or an eye closure.

79 s essential for the organismal survival upon prolonged fasting and maintaining systemic homeostasis u

80 ung at extremely high rates while undergoing prolonged fasting, making lactation a tremendously energ

81 haracteristic of clinical manifestation of a prolonged fever.

82 Only within a narrow range does prolonging GABA(B) receptor activity promote channel ope

83 gene expression of apc/ebp We find that this prolonged gene expression is not dependent on de novo tr

84 isms by which Trial 2 achieves the essential prolonged gene expression of apc/ebp We find that this p

85 ocesses may have been one contributor to the prolonged glaciations if these were near-global.

86 2 (IL-2) combined with low-dose rapamycin to prolong graft survival.

87 of children with cancer that contributed to prolonged grief for parents; these were different for mo

88 nts are at an increased risk for intense and prolonged grief responses.

89 ariable models for odds to complications and prolonged (>=6 days) length of stay were built.

90 ort (1-2 days), intermediate (3-6 days), and prolonged (>=7 days) and compared for risk factors and o

91 enic clonal groups demonstrate an especially prolonged gut persistence and high rate of bacteriuria w

92 e health care environment, which can lead to prolonged HAI outbreaks.

93 ong-QT syndrome (LQTS) is characterized by a prolonged heart rate-corrected QT interval (QTc).

94 geting of cellular Hsp90, which results in a prolonged heat shock response despite concomitant degrad

95 Prolonged high-temperature extreme events in the ocean,

96 (4.0 +/- 2.0 mg CH(4) m(-2) hr(-1) ) due to prolonged higher WT and more optimal methanogenesis cond

97 nction in humans.(1-9) However, there are no prolonged, highly controlled experimental studies testin

98 rrent smoking (aOR 3.1; 95% CI: 2.2-4.4) and prolonged history of coughing in the source case at enro

99 istent with anal cancer promotion by severe, prolonged HIV-induced immunosuppression.

100 may face barriers to discharge, which could prolong hospital length of stay (LOS) and increase finan

101 (odds ratio, 10.4; 95% CI, 5.9-18.1), suffer prolonged hospital stay (odds ratio, 4.4; 95% CI, 3.0-6.

102 To prevent prolonged hospital stay, initiatives should in addition

103 inst systemic Candida albicans infection and prolonged host survival.

104 apamycin with IL-2 for 3 weeks significantly prolonged human islet allograft survival.

105 Simultaneous endo-epi phase mapping of prolonged human persistent AF recordings shows significa

106 cation end-products (AGEs) accumulate during prolonged hyperglycemia, but the mechanistic pathways th

107 e kinase 1), and in a postnatal model due to prolonged hyperoxia.Methods: ETX or sFlt-1 were administ

108 We also provide evidence that prolonged hypoxia down-regulates kindlin-2 expression, l

109 ditional day = 0.55; 95% CI, 0.37-0.80), but prolonged ICU- and hospital stays.

110 melanoma cells to investigate the effects of prolonged IFNgamma treatment on mRNA translation.

111 ere disease, apparent diagnostic delays, and prolonged illness, whereas other patients lacked symptom

112 significant clinical consequences, including prolonged immunosuppression, poor vaccine responses and

113 ross all regions, with the greatest and most prolonged increases occurring in the globus pallidus and

114 r GES-harboring isolates, a double inoculum, prolonged incubation, or both was evaluated, with each m

115 Using prolonged incubation, we discovered that wild-type casto

116 astrointestinal infection in humans, however prolonged infection can be seen in cases with underlying

117 Chronic hepatitis B is caused by prolonged infection with the hepatitis B virus (HBV), wh

118 mcitabine plus dacarbazine in LMS; high-dose prolonged-infusion ifosfamide in SS; etoposide plus ifos

119 by gamma-aminobutyric acid (GABA) results in prolonged inhibition of neurotransmission, which is cent

120 del, GSK3008348 engages alphavbeta6, induces prolonged inhibition of TGFbeta signaling and reduces lu

121 n-integration strategy in each and confirmed prolonged integration in all but one subject.

122 Prolonged intermittent theta burst stimulation (piTBS) w

123 extran sulfate sodium-induced colitis due to prolonged intestinal inflammation and impaired tissue re

124 ospitalized for serious infections requiring prolonged intravenous antibiotics may face barriers to d

125 elter at the age of 17 years had experienced prolonged journeys where they spent months or years livi

126 CI: 1.26-2.82; I2: 96%; p-value < 0.01), and prolonged labor (7,516 FGM/C and 8,060 non-FGM/C partici

127 n to experience dyspareunia, perineal tears, prolonged labor, and episiotomy.

128 nia patients, including higher mortality and prolonged length of hospital stay.

129 ve adrenomedullin was also associated with a prolonged length of stay (odds ratio, 1.85; 1.49-2.29) a

130 The C-statistics results for prediction of prolonged length of stay were 85 +/- 3% accuracy and AUR

131 ior persistence of T cells and significantly prolonged leukemia control in vivo, confirmed by a secon

132 es with reduced mitochondrial translation to prolong lifespan and stimulate stress response such as t

133 e between two TPA-TCBD entities in 3 seem to prolong lifetime of the CS state.

134 emonstrated with quick formation of 3 ps but prolonged lifetime of ~0.5 mus.

135 nced power performance, improved durability, prolonged lifetime, and reduced cost for automotive and

136 1, and the reduced aggregation following the prolonged LPS challenge as compared to wild type (WT) ne

137 t in suppressing tumor initiation suggesting prolonged mammary exposure may improve efficacy.

138 overcomes the rapid ductal clearance of CPX, prolongs mammary tissue persistence, improves efficacy a

139 ncreases the droplet stability, allowing for prolonged mapping and the use of highly evaporative sali

140 ective care practices for patients receiving prolonged mechanical ventilation.Methods: We performed a

141 ression of cleaved caspase-3, and leads to a prolonged median survival of the mice (36.5 vs. 22.5 d,

142 In this review, we detail how prolonged metabolic stress leads to adipose tissue dysfu

143 the depletion of centrosome proteins in NPCs prolongs mitosis and increases TP53-mediated apoptosis.

144 ng a feedback control of APC/C to SAC during prolonged mitotic arrest.

145 Prolonged monitoring and trials of otoprotective agents

146 p and rebound in ensemble mean FR induced by prolonged monocular deprivation.

147 asticity, and can rescue deficits induced by prolonged monocular deprivation.

148 d in proinflammatory T cell differentiation, prolonged monocyte major histocompatibility complex II u

149 nt mice with Borrelia burgdorferi results in prolonged nonresolving Lyme arthritis.

150 During prolonged nutrient restriction, developing animals redis

151 against cerebrovascular dysfunction despite prolonged obesity.

152 (SCT) injection of Sunb-malate MS provided a prolonged ocular drug retention and did not cause ocular

153 fore viscosity enhancement for increased and prolonged ocular surface contact and drug absorption.

154 l particles have improved stabilities during prolonged operation compared to their monometallic count

155 erferences, along with good stability during prolonged operation in artificial ISF.

156 Prolonged optogenetic dFB activation nevertheless achiev

157 cell transplant recipients often results in prolonged or indefinite antifungal treatment.

158 To avoid this, prolonged or intermittent social distancing may be neces

159 groups, a proportion of patients had clearly prolonged or shortened CLTs.

160 dels, it is shown that gCM-MNs significantly prolong overall mouse survival by controlling both local

161 mate goal to prevent or delay recurrence and prolong overall survival.METHODSTwenty-eight patients wi

162 thway ligands and targets are activated upon prolonged p16(INK4a) expression, and Wnt inhibition supp

163 animal kingdom, particularly in species with prolonged parental care, e.g., [8, 9].

164 Together, our results suggest a prolonged period of basal ganglia iron enrichment that e

165 the controlled release of vitamin B6 over a prolonged period of observation.

166 are highly susceptible to infection, with a prolonged period of oral and nasal viral shedding that i

167 a reopening, but would quickly settle into a prolonged period of time with stable, slightly declining

168 h numerous seeds from multiple sources and a prolonged period of unrecognized community spreading.

169 r, a full lockdown cannot be sustained for a prolonged period.

170 ity observed with the modified electrode for prolonging period indicated that the sensitivity of the

171 c-dependent, and require repeated courses or prolonged periods of antibiotic therapy.

172 developed and tested the feasibility of more prolonged periods of NMP.

173 warming-up while listening to music; or (5) prolonged periods of training at a specific time of day.

174 in vitro and can be delivered topically for prolonged periods through controlled release by specific

175 reduced before the technique can be used for prolonged periods.

176 atin chemotherapy to gefitinib significantly prolonged PFS and OS but increased toxicity in patients

177 r time-dependent photocurrent generation and prolonged photocurrent decay, originated from charge tra

178 pothesize that it may act to protect against prolonged placental hypoxia seen in preeclampsia.

179 rgic innervation to abDGCs develops during a prolonged post-mitotic period and running scales both SS

180 efects in muscle function, consistent with a prolonged postnatal role for EphA4 in adolescent muscle

181 Prolonged postoperative fasting has been the traditional

182 The prolonged presence of PEGylated rhDNase in lung airspace

183 ratory symptoms, prior antibiotic treatment, prolonged prodromal respiratory symptoms and fever, and

184 The feedback loop further enables prolonged production of BisDC, which ensures expression

185 02684006 ), which demonstrated significantly prolonged progression-free survival (PFS) with first-lin

186 inib in the first-line setting significantly prolonged progression-free survival compared with a fixe

187 m-based chemotherapy as first-line treatment prolonged progression-free survival in patients with met

188 KdD significantly prolonged progression-free survival versus Kd in patient

189 expression late in infection is mediated by prolonged promoter-proximal pausing.

190 tunistic infection requiring indications for prolonged prophylaxis to be defined.

191 ptoid modulated the rate of drug release and prolonged protein stability against proteolytic hydrolys

192 on of YAP or TAZ resulted in more severe and prolonged proteinuria in response to injury, as well as

193 e junction length changes that saturate with prolonged pulse durations.

194 as well as to the temporal stability of more prolonged pupil-linked arousal states.

195 We found PR interval shortening and prolonged QRS duration, as well as atrioventricular bund

196 stemic inflammation per se can significantly prolong QTc during acute infections, via cytokine-mediat

197 ot result in a significant change in risk of prolonged QTc.

198 Furthermore, prolonged RA exposure phenocopies LSD1 inhibition, sugge

199 nists, norbinaltorphimine (norBNI), produces prolonged receptor inactivation by a cJun kinase mechani

200 As cells that show prolonged recruitment to sites of injury or pathology, m

201 ) into phosphate buffer for 24 h followed by prolonged release for at least another 48 h.

202 o the infection site, as well as the lack of prolonged release.

203 ssible in macaques with MION, despite MION's prolonged response function.

204 rologically favorable survival declines with prolonged resuscitation.

205 muPET/CT imaging showed high uptake and prolonged retention of an 89Zr-labeled surrogate of PEG~

206 vity against FRalpha is also associated with prolonged RFS.

207 Stalled cells exhibited prolonged S-phase, were defective in DNA synthesis and h

208 ize and/or membrane ionic permeability under prolonged salt stress.

209 grams targeting more diverse populations and prolonged sampling times are required.

210 Based on data from prolonged scans, we generated maps that visualized the p

211 ce quality of life in individuals who suffer prolonged seizures.

212 sufficient to prevent cell cycle exit and to prolong sensory tissue growth.

213 -adrenergic-stimulated cardiomyocytes led to prolonged SERCA activation, presumably because 14-3-3 pr

214 Prolonged sitting time is an emerging risk factor that e

215 ce of B cells at the time of transplantation prolonged skin graft survival.

216 The colder, more humid conditions and prolonged snow-coverage at north exposure likely influen

217 ynurenine/AHR signaling in BMM s to maintain prolonged SOCS1 expression.

218 ful for exploring the health consequences of prolonged spaceflight.

219 n promotes atrial fibrosis and increases and prolongs spontaneous episodes of atrial fibrillation, wh

220 terest included hospitalization, intubation, prolonged stay, sepsis, and death.

221 +) B cells tended to undergo apoptosis after prolonged stimulation, which may be considered a negativ

222 or supplying vesicles rapidly in the face of prolonged stimulation.

223 mmobilized PALs retain higher activity after prolonged storage and confer reusability for over 100 ru

224 After prolonged storage or during the shipment of raisins, a c

225 nerability to severe stress using the single-prolonged stress (SPS) model in male rats.

226 enable cells to conserve energy, prepare for prolonged stress and accelerate recovery.

227 iated inactivation and are more stable under prolonged stress conditions.

228 Here, we utilized single prolonged stress, a validated rodent model of post-traum

229 Intriguingly, however, under prolonged stress, mutant mice develop larger tumors and

230 Floor bleach cleaning led to prolonged, substantial decreases of up to 71-90% due to

231 FN-alpha) treatment of hepatocytes induced a prolonged suppression of human and duck hepatitis B viru

232 The data demonstrate that salbutamol can prolong survival and increase NMJ number in a severe mod

233 Administration of the PD1 antibody did not prolong survival of KPC mice with 0, 1, or 2 alleles of

234 (IRE), a nonthermal ablative technique, may prolong survival of patients with locally advanced pancr

235 and hematologic response was associated with prolonged survival (P = .0291).

236 CTR was associated with prolonged survival (time-dependent HR 0.23, 95% CI: 0.12

237 ozygous null mice demonstrated significantly prolonged survival compared with wild-type.

238 ng 10% plasticizer and either 60 or 50% PLGA prolonged survival from 27 to 70 days in a GBM xenograft

239 ation reduced the number of GICs in vivo and prolonged survival in syngeneic and patient-derived orth

240 RAF3 from B lymphocytes in mice leads to the prolonged survival of mature B cells and expanded B cell

241 s exhibit significant antitumor activity and prolonged survival relative to all other treatment group

242 ted with reduced levels of RAC1 and RAC2 and prolonged survival, whereas elevated expression of RAC1

243 aft model leading to disease attenuation and prolonged survival.

244 cient mosquitoes present a lower viremia and prolonged survival.

245 d resisted TNF-induced apoptosis, supporting prolonged survival.

246 blocking ASOs suppressed repeat toxicity and prolonged survival.

247 e growth of subcutaneous melanoma tumors and prolonging survival.

248 tection and accurate staging are critical to prolonging survival.

249 t to prevent neuronal loss and significantly prolongs survival.

250 treated with antibiotic therapy still shows prolonged symptoms of fatigue, musculoskeletal pain, and

251 Given that prolonged tentacle retraction reduces foraging opportuni

252 PEG) of 20 to 40 kDa was previously shown to prolong the residence time of rhDNase in the lungs of mi

253 To prolong the residence time, absorption and bioavailabili

254 3S and KCNH2-R685P, lumacaftor paradoxically prolonged the APD90 in KCNH2-G604S iPSC-CMs.

255 ty of CREB activity to Ca(2+) elevations and prolonged the duration of CREB activation to more than 2

256 ficantly decreased the R/P rate (P = 0.001), prolonged the R/P-FS time (P = 0.032) and improved the f

257 Brensocatib treatment prolonged the time to the first exacerbation as compared

258 Prolonging the clinical effectiveness of beta-lactams, w

259 response to viremia was profoundly delayed, prolonging the duration of viremia and potential for tra

260 These findings show that prolonging the half-life of Nkx3.1 reduces proliferation

261 lucose homeostasis in multiple mouse models, prolonging the healthy life span.

262 further improve the gene therapy efficacy by prolonging the release of nucleic acid drug payload for

263 be developed as an anti-bacterial agent for prolonging the shelf life of tuna fish.

264 dampening age-specific immune responses and prolonging the survival of old cardiac allografts compar

265 h of both primary tumors and distant tumors, prolonging the survival of tumor-bearing mice.

266 the escape of holes from trap states, which prolongs the apparent lifetime of mobile electrons in th

267 g enzyme, fatty acid amide hydrolase (FAAH), prolongs the regulatory effects of endocannabinoids and

268 In the long term, it prolongs the survival time of the treated patients.

269 s occur frequently in pediatric populations, prolonging their hospitalization and increasing the heal

270 ad occurred received at least one other life-prolonging therapy.

271 Mathematical models imply that a prolonged time (decades) elapses from the development of

272 could differentiate in vivo, but required a prolonged time of four to seven months to migrate from t

273 This is explained by the prolonged time to response seen in many patients, probab

274 allowed LEC culture to remain infected for a prolonged time.

275 48%) or antibodies in 6 (29%) controls for a prolonged time.

276 lout), can provide external irradiation over prolonged times.

277 ates on multiple samples of information over prolonged timescales, but only if subjects actually inte

278 stric emptying, slowed colonic motility, and prolonged total gastrointestinal transit.

279 ophil elastase for 3 days, which resulted in prolonged tracheal mucus velocity reduction, mucus hyper

280 es the advantage of combination therapies in prolonging transplant survival.

281 d for the treatment of severe pain; however, prolonged treatment with these drugs leads to the develo

282 decreased donor-specific antibodies and, on prolonged treatment, modulated rejection-related gene-ex

283 ination treatment on cognition observed with prolonged treatment.

284 he transcriptional and phenotypic effects of prolonged treatments, indicating durable changes in cell

285 sults: PSMA RNT or anti-PD-1 alone tended to prolong TTP (isotype control, 25 d; anti-PD-1, 33.5 d [P

286 urgery, compared to 4 patients (3.8%) in the prolonged TTS arm (P = 1.0).

287 Prolonged UDCA administration reduced the incidence of a

288 Neither acute nor prolonged UDCA treatment altered the incidence of reperf

289 Many ventilated COVID-19 patients require prolonged ventilation.

290 Baboons had prolonged viral RNA shedding and substantially more lung

291 r-triphosphate exhibits a long half-life and prolonged virological effects.

292 f antibody-producing B cells and suffer from prolonged virus infections.

293 need and acquisition of recovery sleep after prolonged wakefulness is an important issue in sleep res

294 signed to reduce and limit the impact of the prolonged warm ischemia inherent to the uDCD process, an

295 bank at depth in peatlands is responsive to prolonged warming.

296 Mice given an antibody against TLR2 had prolonged whole gut transit times; their colonic LMMP ha

297 Participants underwent prolonged wireless reflux monitoring (off PPIs for >=7 d

298 by the study investigator was significantly prolonged with atezolizumab versus control (15.1 vs 10.6

299 DFS was not significantly prolonged with capecitabine versus observation [hazard r

300 depends on accumulation of Naked/NKD during prolonged Wnt stimulation.