ライフサイエンスコーパス: promiscuity

1 an be presented by multiple alleles (epitope promiscuity).

2 y in ligand-receptor interactions as well as promiscuity.

3 ther regions of the human PrP(c) to increase promiscuity.

4 at demonstrate specificity in the context of promiscuity.

5 ns, while also leading to pro-B cell lineage promiscuity.

6 te a potentially valuable source of chemical promiscuity.

7 lexibility may enhance T cell receptor (TCR) promiscuity.

8 le sites in manifesting such pharmacological promiscuity.

9 pensation, lipophilic ligand efficiency, and promiscuity.

10 erface to binding affinity, specificity, and promiscuity.

11 ous scaffolds with very different degrees of promiscuity.

12 ferases that often show broad sugar acceptor promiscuity.

13 ntegrases - paying testament to past genomic promiscuity.

14 inversely correlated with AhR ligand-binding promiscuity.

15 providing a structural explanation for AI4's promiscuity.

16 d for the tolerance of enzymes to metabolite promiscuity.

17 which is likely a result of their functional promiscuity.

18 etoxication enzymes, which exhibit catalytic promiscuity.

19 exhibit equivalent levels of T cell epitope promiscuity.

20 the effect of physicochemical parameters on promiscuity.

21 at the condom machines led to an increase in promiscuity.

22 that can be re-engineered to increase intein promiscuity.

23 rstanding both pocket promiscuity and ligand promiscuity.

24 alleles, referred to as an epitope's binding promiscuity.

25 between COX isoforms that explain substrate promiscuity.

26 ich implies an impressive level of substrate promiscuity.

27 cided to perform a systematic study on their promiscuity.

28 at are generally responsible for introducing promiscuity.

29 ses may be a stronger predictor of inhibitor promiscuity.

30 ss was maximal under conditions of catalytic promiscuity.

31 gle enzymes with varying levels of catalytic promiscuity.

32 jects with different HLA alleles, indicating promiscuity.

33 ledge the biological importance of catalytic promiscuity.

34 d kinase inhibitors, with a wide spectrum of promiscuity.

35 loaded WT1 peptide, indicative of Ag-binding promiscuity.

36 s, allelic polymorphism, and peptide-binding promiscuity.

37 iscover underground metabolism due to enzyme promiscuity.

38 responses, showing that LasR displays ligand promiscuity.

39 ed off-target metabolism arising from enzyme promiscuity.

40 loss, evolution of substrate preference and promiscuity.

41 interactions responsible for this selective promiscuity.

42 gsIJK, which possessed significant substrate promiscuities.

43 t is successfully prevented by female sexual promiscuity, a paternity dilution strategy.

44 manipulating queen eyesight to reduce queen promiscuity across mating flights.

45 tructural plasticity in the groove generates promiscuity allowing accommodation of hundreds of differ

46 c mechanistic understanding is confounded by promiscuity among E3 ligase/substrate interactions and u

47 s of performing counter-screens for bioassay promiscuity and assay interference, and raise caution ab

48 Combining enzyme substrate promiscuity and bioorthogonality thus appears as a power

49 A key obstacle has been promiscuity and consequent adverse effects of drugs targ

50 Both promiscuity and dependence on F1760 seen in Nav1.5 were

51 ed undesirable, but the combination of their promiscuity and difficulties associated with optimizing

52 Here, we review the concepts related to promiscuity and examine several cases of highly promiscu

53 ts obtained revealed a high degree of enzyme promiscuity and experimental results which together with

54 nd eCas9 showed the best balance between low promiscuity and high on-target activity with canonical g

55 istic features that underline this converged promiscuity and how this promiscuity drove the parallel

56 promiscuous activity, Ca(2+) suppresses the promiscuity and induces high cleavage fidelity.

57 vide insights into understanding both pocket promiscuity and ligand promiscuity.

58 Wanting to understand how catalytic promiscuity and other factors may influence evolution ac

59 Binding promiscuity and plasticity allow IDPs to interact with m

60 By exploiting substrate promiscuity and protein engineering, the scope of reacti

61 a molecular basis for either selectivity or promiscuity and provides a benchmark for experimental de

62 This study highlights the vast extent of ACE promiscuity and provides a valuable platform for further

63 alized metabolic evolution include enzymatic promiscuity and recruitment of primary metabolic enzymes

64 ites) identified 55 kinases with significant promiscuity and revealed unexpected inhibitor cross-acti

65 say can have utility for predicting compound promiscuity and should complement predictive methods tha

66 our study provides the structural basis for promiscuity and specificity of Epa adhesins, which might

67 Catalytic promiscuity and substrate ambiguity are keys to evolvabi

68 ented the engineering of ATs with low native promiscuity and the study of any potential gatekeeping e

69 lar basis to account for its broad substrate promiscuity, and (iv) TnmH as a biocatalyst enables the

70 varies with 1) pathway structure, 2) enzyme promiscuity, and 3) network redundancy.

71 opy, an overall measure of signaling pathway promiscuity, and computable from integrating a sample's

72 ts the first example of photo-induced enzyme promiscuity, and highlights the potential for accessing

73 biases and promotes helping; and sib-mating, promiscuity, and reproductive autonomy also modulate the

74 rinciples and properties of enzyme function, promiscuity, and repurposing provides lessons for engine

75 in of life, were low in activity but high in promiscuity, and that these early ribozymes gave rise to

76 Overall, we suggest that catalytic promiscuity, and the ease or difficulty of remodeling an

77 The ligand promiscuity appears to be an adaptation to match a broad

78 ffinity (<500 nM), a level of ligand-binding promiscuity approaching the level of heat shock protein

79 ombination therapies, discuss potential drug promiscuity arising from off-target effects, comment on

80 other's reactions, consistent with catalytic promiscuity as an important driver in the evolution of n

81 e roles of substrate ambiguity and catalytic promiscuity as drivers of evolution, and the challenges

82 s into D(3)R ligand systems to minimize drug promiscuity at other aminergic GPCR sites.

83 tory evolution for the purpose of predicting promiscuity at the genome scale.

84 d biochemical data provide insight into dNTP promiscuity at the secondary allosteric site and how enz

85 demonstrate the plausibility of this second, promiscuity-based model.

86 re, we explore the limits of this remarkable promiscuity by mapping two denatured proteins with very

87 arative enzymology and analysis of catalytic promiscuity can provide mechanistic and evolutionary ins

88 Promiscuity cliffs provide immediate access to such modi

89 On the basis of our analysis, we introduce "promiscuity cliffs" as pairs of structural analogs with

90 work entropy, a measure of signaling pathway promiscuity, computable from a sample's genome-wide expr

91 This suggests that binding promiscuity confers kinetic advantages to NTF2 by expedi

92 neered variants of GSTA1-1 and the catalytic promiscuity correlates strongly with characteristics of

93 In the future, MAR's substrate promiscuity could be leveraged to produce chiral-branche

94 Promiscuity counts allow for a better understanding of a

95 nient or efficient method to obtain in-depth promiscuity counts for compounds.

96 ervices to interact with PubChem and provide promiscuity counts in a variety of categories along with

97 In principle, widespread polyandry (female promiscuity) creates potential for sexual selection in m

98 ing entropy, a measure of signalling pathway promiscuity derived from a sample's genome-wide gene exp

99 striking feature of this process is the vast promiscuity displayed by PBPs in tolerating entirely unn

100 results indicate that differences in epitope promiscuity do not account for the observed differences

101 line this converged promiscuity and how this promiscuity drove the parallel divergence of organophosp

102 A series of promiscuity, druglike, and ADMET filters were applied to

103 replacements were found to lead to dramatic promiscuity effects.

104 This promiscuity enabled us to define a nucleophile composed

105 We suggest that possessing some ligand promiscuity endows LasR with the ability to optimally re

106 PubChem promiscuity fills this gap.

107 ly, bank voles (BV) exhibit an unprecedented promiscuity for diverse prion isolates, arguing that ban

108 ure druglike chemical space, consider ligand promiscuity for hit and lead finding, and provide fresh

109 ferent reactions but often exhibit catalytic promiscuity for one another's reactions, consistent with

110 ted multienzyme system revealed considerable promiscuity for orthologs with distinct substrate specif

111 use an unprecedented mechanism of substrate promiscuity for the production of numerous and diverse l

112 acids onto bacterial cell surfaces with vast promiscuity for the side-chain identity.

113 The site-dependent promiscuity forms a foundation to better understand Nav

114 nerations were reintroduced to sociality and promiscuity (free mate choice), they adapted within two

115 ular structures that are predicted by enzyme promiscuity from canonical pathways.

116 principles to infer the roles of functional promiscuity, gene dosage, gene duplication, point mutati

117 c engineering, and a continuing trend of CYP promiscuity generating complex networks in terpenoid bio

118 However, chiral promiscuity has been identified for a number of enzyme f

119 drugs for complex disorders, unintended drug promiscuity has detrimental contribution to side effects

120 ace and physical features of this side chain promiscuity have not been determined systematically.

121 Some insights into this high-promiscuity/high-affinity behavior and its impact on imm

122 owever this is impractical due to off-target promiscuity (i.e., one protease targets multiple differe

123 t is becoming widely accepted that catalytic promiscuity, i.e., the ability of a single enzyme to cat

124 activity regulation, feedback, and catalytic promiscuity impede our understanding of context-dependen

125 s, the biophysical properties that allow for promiscuity in a protein selected for high-affinity bind

126 alism, we have analyzed patterns of compound promiscuity in a publicly available small molecule micro

127 o examine the mechanisms responsible for the promiscuity in AhR ligand binding, we determined the eff

128 neity, and driven by the degree of signaling promiscuity in cells.

129 ships between physicochemical properties and promiscuity in detail.

130 ere was no consistent difference or trend in promiscuity in epitopes contained in HIV, M. tuberculosi

131 ine the relationship between flexibility and promiscuity in five PDZ domains: the human Dvl2 (Disheve

132 effects mechanistically rely on HUalphaalpha promiscuity in forming multiple electrostatically driven

133 The present study showed MLLT10 promiscuity in pediatric T-ALL and identified a specific

134 ntains anti-aphrodisiac molecules that deter promiscuity in post-copulatory females, conferring fitne

135 Promiscuity in recruiting TBK1 via independent signals m

136 ich is not expected from currently perceived promiscuity in RNA-RNA interactions.

137 it a high level of catalytic proffciency and promiscuity in structurally similar active sites.

138 ay, representing another example for pathway promiscuity in Sulfolobus species.

139 al analyses has revealed more complexity and promiscuity in the protein interactions driving CCP matu

140 ibe an approach toward exploring such enzyme promiscuity in the space of a metabolic network.

141 allosteric mechanism of InrS permits greater promiscuity in vitro than CsoR.

142 Based on analysis of snapshots of catalytic promiscuity "in transition", we develop possible models

143 phingolipid synthesis and generate catalytic promiscuity, incorporating alanine or glycine into the p

144 at which a compound was active was used as a promiscuity index.

145 The promiscuity inherent to minor groove DNA recognition rat

146 and should enable future efforts to engineer promiscuity into other naturally split inteins.

147 A promiscuity investigation of the thymidylyltransferase C

148 an bind other non-native sequences, and this promiscuity invites the possibility for rational design

149 e-magnitude differences in apparent compound promiscuity involving between 50 and 97 unrelated target

150 The study of compound promiscuity is a hot topic in medicinal chemistry and dr

151 We propose that this promiscuity is a molecular mechanism of adaptation to li

152 However, catalytic promiscuity is a poorly understood property, and no ther

153 Promiscuity is a trait whose value would depend on selec

154 relationship between protein flexibility and promiscuity is an area of active research and is perhaps

155 ingly identified, but the molecular basis of promiscuity is currently only little understood.

156 The mechanism underlying this promiscuity is derived from the fact that SRs share comm

157 This enhanced substrate promiscuity is not accompanied by significant changes in

158 On the basis of our analysis, promiscuity is not an inherent feature of molecular scaf

159 It is now shown that this enzymatic promiscuity is not exclusive to side chains, but that C-

160 Enzyme promiscuity is typically studied experimentally using mu

161 A quantitative index of catalytic promiscuity is used to compare engineered variants of GS

162 iscuous reactions, suggesting that catalytic promiscuity is widespread in the AP-superfamily.

163 ry sexual selection (PSS), fuelled by female promiscuity, is credited with the rapid evolution of spe

164 d as NDM-1, represents an example of extreme promiscuity: It hydrolyzes and inactivates nearly all kn

165 etabolome databases in addition to an enzyme promiscuity library.

166 roteins, as both high stability and enhanced promiscuity (likely contributors to high evolvability) a

167 compounds had drawbacks including off-target promiscuity, low activity against human nNOS, and only m

168 of the coexistence of high levels of female promiscuity, low paternity, and costly male care, and em

169 ity assurance: despite high levels of female promiscuity, males of a marine snail provide exclusive,

170 ically irrelevant activity, highlighting how promiscuity may be an evolutionary vestige of ancestral

171 In this regard, drug promiscuity may be leveraged to interfere with multiple

172 ere ineffective sulfatases, and this limited promiscuity may have provided a driving force for foundi

173 nes transcripts demonstrated a high level of promiscuity, meaning that some transcripts produced as m

174 ights into the dynamic reaction cascades and promiscuity mechanisms of class I terpene synthases.

175 UGGT may therefore endow the enzyme with the promiscuity needed to recognize and reglucosylate its ma

176 uences and derived peptides revealed agonist promiscuity, not only within, but also between aGPCR sub

177 s, these break new ground in sequence space: promiscuity now connects enzymes with only distantly rel

178 sporter, adopt a canonical binding mode with promiscuity obtained via differential packing in the bin

179 ool to explore the sequence requirements and promiscuities of orthogonal CRISPR-Cas systems in rapidl

180 a split reporter protein, we have tested the promiscuity of a panel of reported kinase inhibitors aga

181 We exploited the promiscuity of bacterial transpeptidases to develop a no

182 ed for exhaustive mass spectra matching, the promiscuity of binding of cisplatin to ubiquitin is reve

183 Our hypothesis accounts for the Na(+)/H(+) promiscuity of bioenergetic proteins, as well as the dee

184 Given the binding promiscuity of C1q's globular region (gC1q), we hypothes

185 This study demonstrates the remarkable promiscuity of central metabolism in bacterial cells and

186 s with low complement activation, but due to promiscuity of complement factors and redundancy of path

187 These data demonstrated the broad substrate promiscuity of Cps2L, with kcat/Km changes for monofluor

188 structural basis of the remarkable substrate promiscuity of CYP2B enzymes.

189 ings highlight the structural plasticity and promiscuity of E2A-AD1 and suggest that E2A binds both t

190 The promiscuity of EcRppH differentiates it from its Bacillu

191 Here, by exploring the substrate promiscuity of endogenous glycosyltransferases, we devel

192 New insights were gained into the binding promiscuity of enzymes within the prokaryotic L-rhamnose

193 a multifunctional catalyst, which mimics the promiscuity of enzymes, that would catalyze more than on

194 We then analyzed binding promiscuity of epitopes derived from HIV and M. tubercul

195 We also analyzed promiscuity of epitopes from Streptococcus pyogenes, whi

196 10 of the complexes provide evidence of the promiscuity of ExBox(4+) for the various PAHs.

197 ator of the receptor binding specificity and promiscuity of FGFs.

198 ng the molecular mechanism of the functional promiscuity of FPRs.

199 or variation is unlikely to be necessary for promiscuity of host infection.

200 These data highlight the promiscuity of influenza viruses and the need for dilige

201 The actions of TIRAP depend on the promiscuity of its phosphoinositide-binding domain.

202 The innate promiscuity of kinase inhibitors largely results from AT

203 Because of the inherent promiscuity of kinase inhibitors, our results suggest th

204 ACKR2 displays promiscuity of ligand binding and is capable of interact

205 fferent folds, leading to the high degree of promiscuity of ligand-protein interactions at the system

206 Intrigued by the substrate promiscuity of MAR, we probed its utility to produce bra

207 41 was achieved to investigate the substrate promiscuity of MarG.

208 kinetic traps, providing a rationale for the promiscuity of Mia40.

209 The substrate promiscuity of microbial transglutaminase (mTG) has been

210 of redundancy among miRNAs, coupled with the promiscuity of miRNA binding sites in the transcriptome,

211 and molecular modeling has suggested reduced promiscuity of ML351 compared with ML127.

212 In order to study the promiscuity of MtTPS5, (2Z,6E)-FDP, an analogue of presu

213 4-Me-7-NO2-L-Trp uncovered remarkable regio-promiscuity of nitration biocatalysts.

214 Exploiting the fortuitous promiscuity of OGT, we show that S-GlcNAc is a hydrolyti

215 Promiscuity of pattern recognition receptors, such as re

216 rgZ for hydrophobic heptapeptides versus the promiscuity of peptide binding in the homologous protein

217 The efficiency and promiscuity of phage Mu transposition was exploited to d

218 NA was strain dependent, showing a different promiscuity of prion strains in cofactor utilization.

219 To investigate the catalytic promiscuity of ProcM, we chose four prochlorosins previo

220 d a biosynthetic approach that harnessed the promiscuity of several pathway genes to produce cannabin

221 similar between aGPCRs allowing for agonist promiscuity of several Stachel-derived peptides.

222 osphorylated EGFR, consistent with the known promiscuity of SH2 domains.

223 To determine potential functional promiscuity of similar DNA binding domains, we replaced

224 inding affinity between GAS6 and AXL and the promiscuity of small molecule inhibitors represent impor

225 The promiscuity of SPT therefore links serine and mitochondr

226 ere we exploit amino acid metabolism and the promiscuity of SPT to modulate the endogenous synthesis

227 stion, we compared the in silico HLA binding promiscuity of T cell epitopes from pathogens with disti

228 Substrate promiscuity of terpene synthases provides organism acces

229 Promiscuity of terpene synthases results in the enormous

230 Owing to the promiscuity of the 7 bp overlap sequence in its att site

231 in nature and also demonstrates the receptor promiscuity of the A. orientalis sulphur-delivery system

232 ism and raising questions about the reported promiscuity of the AHR.

233 The promiscuity of the amide synthase of S. hygroscopicus wa

234 urthermore, we demonstrate the tolerance and promiscuity of the anthraquinone heterologous biosynthet

235 gp120 demonstrated that the antigen-binding promiscuity of the antibody compensates for the molecula

236 The promiscuity of the aptamer can also be used to distingui

237 Studies focused on the inherent promiscuity of the biosynthetic machinery elucidated a m

238 ining disaccharides, taking advantage of the promiscuity of the cellobiose-PTS system.

239 artificial metalloenzymes that exploits the promiscuity of the central hydrophobic cavity of the tra

240 the incompatibility is due to the functional promiscuity of the DNA-binding protein ParRpB171, which

241 In this work, we evaluate the promiscuity of the early structure diversity-generating

242 rates or products of ACE, demonstrating high promiscuity of the enzyme.

243 Given the promiscuity of the enzymes involved, it has not yet been

244 e benzoyl-CoA pathway, apparently due to the promiscuity of the enzymes involved.

245 teristics of peptide binding specificity and promiscuity of the five PDZ domains.

246 Moreover, because of the promiscuity of the galactosyltransferase, 18 unique O-gl

247 otype is probably attributable to functional promiscuity of the HNF1beta transcription factor, involv

248 ceL-TerL intein, indicating a high degree of promiscuity of the Int(C) fragment of the GOS-TerL intei

249 Substrate promiscuity of the most active chimera was further asses

250 esign highly specific siRNAs by limiting the promiscuity of their seed sequences (positions 2-8 of th

251 atform accounts for the remarkable substrate promiscuity of these domains.

252 d activation barriers suggest that the broad promiscuity of these enzymes arises from cooperative ele

253 ioredoxin reductases co-evolved and that the promiscuity of thioredoxins toward downstream electron a

254 Results presented herein demonstrate the promiscuity of this last step by means of a set of "comp

255 he first example of exploiting the catalytic promiscuity of transaminases as a tool for novel transfo

256 requirements and explore the differences in promiscuity of two pyridine synthases, TclM and TbtD, ul

257 l genetic mutations that reveal the rampant "promiscuity" of genotype-phenotype relationships.

258 The origin of the selectivity (or promiscuity) of the metal-ion-mediated base pairing is d

259 be approximated by computing the signalling promiscuity, or entropy, of a cell's transcriptome in th

260 isplays both enhanced activity and substrate promiscuity over a chemical library of 313 ncAAs.

261 ications, gene rearrangements, and substrate promiscuity potentiated the evolution of glucosinolate b

262 Biochemical assays examine catalytic promiscuity, provide mechanistic insight, and demonstrat

263 These data establish how promiscuity, rather than specificity, can be a beneficia

264 As a result of this promiscuity, reassignment of the CUN codon box from leuc

265 already exhibited increased flexibility and promiscuity relative to the other communities.

266 which predicts that overlapping patterns of promiscuity result from sharing a common multifunctional

267 ther possibility fosters selection for queen promiscuity, revealing a novel benefit of it for eusocia

268 omyces species, and their apparent substrate promiscuity reveals potential for their development as b

269 be aided by enzymes that practice catalytic promiscuity, such as these two unrelated DNA glycosylase

270 esults showed a considerably lower degree of promiscuity than initially expected, even for those memb

271 osa PAO1 K648 (pvd-, pch-) exhibited greater promiscuity than that of E. coli for the uptake and util

272 eae family and their bioactivity, functional promiscuity that could be exploited as leads in developi

273 we describe a method for achieving catalytic promiscuity that uses the photoexcited state of nicotina

274 With this higher promiscuity there is a shift in nucleotide occupation of

275 d Tar16 was examined and revealed intriguing promiscuity, thereby opening doors for the targeted engi

276 a surrogate Valpha domain, fostering ligand promiscuity to favor development of beta chains with sel

277 tectures are limited, we harnessed enzymatic promiscuity to generate a focused library of chartreusin

278 How such a transition from promiscuity to pair-bonding could be achieved is puzzlin

279 r sole electron donor TrxR while maintaining promiscuity to their multiple electron acceptors.

280 dicts a compound's high throughput screening promiscuity, to a higher degree than the original data m

281 CndF displays promiscuity toward different beta-keto carboxylate and e

282 yl group, (ii) TnmH exhibits broad substrate promiscuity toward hydroxyanthraquinones and S-alkylated

283 Enzyme promiscuity toward substrates has been discussed in evol

284 MaDA exhibits a substrate promiscuity towards both dienes and dienophiles, which e

285 In this study, TOMM enzymatic promiscuity was assessed using a currently uncharacteriz

286 ter in its own right, an index of biological promiscuity was developed.

287 erstand the molecular basis of this acceptor promiscuity, we solved the crystal structure of A. fumig

288 To understand the molecular basis for promiscuity, we solved X-ray crystal structures of a SMR

289 zzle, because females can sustain costs from promiscuity, whereas full fertility can be provided by a

290 active site to achieve remarkable catalytic promiscuity wherein the substrate-free conformational en

291 ar function, they can also display substrate promiscuity which can also be essential.

292 adverse events (potentially driven by kinase promiscuity), which preclude their evaluation in nononco

293 andscapes showing a high level of functional promiscuity, which are frequently regulated through post

294 nd were used, Sniper1-Cas9 showed the lowest promiscuity while maintaining high on-target activity.

295 rved detection mechanism combines structural promiscuity with high specificity and enables discrimina

296 Chemokines display considerable promiscuity with multiple ligands and receptors shared i

297 we also find evidence of unanticipated MTase promiscuity with some enzymes apparently also modifying

298 biosynthetic enzymes can display unexpected promiscuity, with human glycosyltransferase pp-alpha-Gan

299 generalized feature driving selectivity and promiscuity within this superfamily and can be in turn u

300 Selection for promiscuity would be especially strong if productivity i