ライフサイエンスコーパス: promiscuous

1 is clade dependent and ranges from strict to promiscuous.

2 sugar metabolism, whereas others were fairly promiscuous.

3 e a protein's cellular destination are often promiscuous.

4 ence studies demonstrated that both CYPs are promiscuous.

5 e pocket for the other adenine appears to be promiscuous.

6 ments is limited, or enzymes are excessively promiscuous.

7 vage sequence specificity; others are fairly promiscuous.

8 ces(1-4,6,7,9), and inhibitory inputs can be promiscuous(10) and unselective(11).

9 This analysis revealed that such "promiscuous 2-aminothiazoles" (PrATs) behaved as frequen

10 re are both serotype-restricted and serotype-promiscuous AAPs in their assembly roles.

11 ging environmental conditions and the rather promiscuous acceptance of diverse substrates by these en

12 ds as substrates, whereas HolE is relatively promiscuous, accepting a range of acyl-CoA and amine sub

13 n the accumulation of ATF2 and RNF20 and the promiscuous accumulation of DDR-associated chromatin mar

14 ts and antagonists were assumed not to exert promiscuous actions at other GPCRs.

15 Although we found that AmTRP-R is highly promiscuous, activated by various ligands including two

16 Clonal selection initially is promiscuous, activating cells with virtually undetectabl

17 al differentiation, blocking the action of a promiscuous activator on cryptic promoters is a critical

18 We noted that Pdr1 is the most promiscuous activator, whereas Yrr1 and Stb5 are selecti

19 analysis of thiG to determine its potential promiscuous active site, which we validate experimentall

20 The promiscuous activities of enzymes provide fertile ground

21 s a permissive PSI-BLAST approach to predict promiscuous activities of metabolic genes.

22 d evolution are versatile biocatalysts whose promiscuous activities represent potentially attractive

23 entical primary functions can have different promiscuous activities.

24 BM3) from Bacillus megaterium, CYP102A1) has promiscuous activity for oxidation of hydrosilanes to gi

25 ain of Escherichia coli in which a secondary promiscuous activity has been recruited to serve an esse

26 ive discontinuous assay, we demonstrate weak promiscuous activity on the decarboxylated substrate 1-(

27 ered for higher activity on oligoglycine has promiscuous activity that allows proteins to be tagged u

28 This endogenous E. coli phosphatase has promiscuous activity that, when overexpressed, compensat

29 However, in vitro tafazzin catalyzes a promiscuous acyl exchange that acquires specificity only

30 Furthermore, E. coli CBL (fold type I) is a promiscuous alanine racemase.

31 The protease is highly promiscuous among diverse N-myristoylated proteins in vi

32 rneurons in the neocortex often connect in a promiscuous and extensive fashion, extending a "blanket

33 orm contiguous helices that are biologically promiscuous and hemolytic.

34 We have previously described promiscuous and immunogenic HLA-DR-restricted peptides d

35 DisA but not YybT (a PDE) whilst TA was more promiscuous and inhibited both DisA and YybT.

36 The host is quite promiscuous and is capable of binding multiple guests wi

37 f di- and tripeptides, making them extremely promiscuous and major contributors to the pharmacokineti

38 asis of differences in parental care between promiscuous and monogamous mammal species?

39 nteraction with other proteins appears to be promiscuous and not exclusive, although the major protei

40 ed the residual phosphorylation of glucose a promiscuous and physiologically irrelevant activity, hig

41 lar functions, but are also prone to forming promiscuous and potentially deleterious interactions.

42 Accessory elements were predominantly promiscuous and prevalent in the distal gut metagenomes

43 Some identified T-cell epitopes are promiscuous and recognizable by the common HLA alleles.

44 We conclude that promiscuous and specific RNA-binding activities of PRC2

45 In this effort, promiscuous and weak interactions between ligands and re

46 omplished with ATs that are either naturally promiscuous and/or located in terminal modules lacking d

47 d to the construction of a highly efficient, promiscuous, and thermostable artificial enzyme that cat

48 Both enzymes are catalytically promiscuous, and we generated 10 different macroamidines

49 mon binding characteristics that explain the promiscuous, and yet high-affinity, association of E3-19

50 enge of primary CLL cells indicated that the promiscuous antigen-binding activity of subset #8 mAbs c

51 ase in glucocorticoid-sensitive AR L702H and promiscuous AR T878A in patients with prior abiraterone

52 Dels, and screen TRIAD libraries to evolve a promiscuous arylesterase activity in a phosphotriesteras

53 Both Polzeta4 and Polzeta5 were most promiscuous at G nucleotides and frequently generated mu

54 tein docking suggested that 6-OH-BDE-47 is a promiscuous ATP-competitive kinase inhibitor; 2) in vitr

55 e presence of azide anion, DAH also exhibits promiscuous azidation activity against dechloroacutumine

56 structural basis for turning nonselective or promiscuous Bcl-2 family ligands into selective PROTACs.

57 Many pathogens are considered promiscuous because they cause disease across a range of

58 This promiscuous behavior also extends to its association to

59 iple cobalamin derivatives and correlate its promiscuous behavior to its structure and unique arrange

60 able aid toward revealing some mechanisms of promiscuous behavior.

61 other CNS receptors, and they resemble known promiscuous binders.

62 These domains and SLiMs have polyspecific or promiscuous binding activities.

63 and provide a biophysical rationale for how promiscuous binding by GR allows functional substitution

64 Finally, we observed that promiscuous binding of Myod1 to neuronal targets results

65 erminal region is conjectured to mediate the promiscuous binding of other ligands.

66 ce the affinity for weak Py-tracts result in promiscuous binding of U2AF2 along mRNAs and impact on s

67 rs encoded in the cognate ligands activate a promiscuous binding pathway that reveals a flexible hydr

68 s were therefore designed to (a) disrupt the promiscuous binding pharmacophore and diminish off-targe

69 1 haplotype is even more permissive than the promiscuous binding shown by the dominantly expressed cl

70 utation selectively alters interactions to a promiscuous binding site that is critical for DNA metabo

71 n the chromatin-binding proteins facilitates promiscuous binding to a wide range of different molecul

72 y candidate peptides of Ara h 1 that display promiscuous binding to MHC class II and induce TH2 cytok

73 icities (amino acids 11-30 and 41-60) showed promiscuous binding to multiple HLA-DR molecules.

74 ne to robustly increase Treg frequencies via promiscuous binding to the glucocorticoid receptor (GR)

75 ighlight how the bromodomain is built toward promiscuous binding with low specificity.

76 h more connections (via increased valencies, promiscuous binding, and topologies that enable multival

77 sitioning, at least in part, plays a role in promiscuous binding.

78 achieve class specificity but also engage in promiscuous binding.

79 r and organ function and can account for the promiscuous bioactivities of phytochemicals, despite the

80 the human dynein interactome by attaching a promiscuous biotin ligase ('BioID') to seven components

81 Here, we show that fusion of the promiscuous biotin ligase BirA(R118G) with RAD18 leads t

82 Most proximity labeling techniques use a promiscuous biotin ligase or a peroxidase fused to a pro

83 The BioID method uses a promiscuous biotin ligase to detect protein-protein asso

84 centered on BioID2, a substantially smaller promiscuous biotin ligase.

85 further benchmark the efficiency of various promiscuous biotin ligases in comparison with one-step a

86 BioID is a method that exploits a "promiscuous" biotin ligase (BirA118R or BirA*) to identi

87 ors SMX-dependent resolution by antagonizing promiscuous BLM activity during ALT recombination.

88 HmK is potent but promiscuous, blocking KcsA-Shaker, Shaker, Kv1.2, and Kv

89 anti-NP action devoid of side effects due to promiscuous CA modulation.

90 This rigorous HTS approach eliminates promiscuous candidate leads, significantly accelerates t

91 ITSM tyrosine phosphorylation motifs to the promiscuous cell-surface phosphatase CD45(2,3), which re

92 er properties may contribute to nonspecific, promiscuous changes in membrane protein and cell functio

93 gnition fundamentally differs from canonical promiscuous chaperone-substrate interactions.

94 crystallin, and HspB5/alphaB-crystallin) are promiscuous chaperones, whereas the chaperone activity o

95 Protocadherins form isoform-promiscuous cis dimers and isoform-specific homophilic t

96 butyrate biosynthesis pathway based upon the promiscuous cleavage of O-succinyl-L-homoserine by cysta

97 dscape model, in bulk experiments we observe promiscuous cleavage under physiological negative superc

98 ures paternity certainty in the face of more promiscuous competitors.

99 In PubChem screening assays, 466 highly promiscuous compounds were identified that were examined

100 MR, an industry-developed counter-screen for promiscuous compounds.

101 -cell compartment preferentially accumulates promiscuous constituents with age as a consequence of hi

102 Using a promiscuous covalent kinase inhibitor (CKI) SM1-71 as a

103 Most negatively selected TCRs exhibited promiscuous crossreactivity toward multiple other major

104 he models were explainable as artifacts from promiscuous crystallization reagents.

105 scherichia coli alanine racemase (ALR), is a promiscuous cystathionine beta-lyase (CBL).

106 We show that promiscuous decisions (high sensitivity, low specificity

107 Thus, the TIG domain is a promiscuous dimerization module that has been appropriat

108 ved highly dynamic cellular interactions and promiscuous distribution of leukaemia cells that migrate

109 Structures of Cap4 reveal a promiscuous DNA endonuclease domain activated through li

110 P-glycoprotein (P-gp), a promiscuous drug efflux pump, has been extensively studi

111 ide effect caused by unintended block of the promiscuous drug target human ether-a-go-go-related gene

112 out effects; therefore, our understanding of promiscuous drugs, polypharmacology-related adverse drug

113 s specific synergies from those arising with promiscuous drugs.

114 uitinates substrates together with UBCH5B, a promiscuous E2 that can function with a broad range of E

115 We find MCV sT to be a promiscuous E3 ligase inhibitor targeting the anaphase-p

116 for cell transformation through targeting of promiscuous E3 ligases, including FBW7, a known MMP-9 an

117 y accumulate at high concentrations to exert promiscuous effects at the beta-cell GLP-1R, as may occu

118 Here we describe a single promiscuous enhancer within the Drosophila Antennapedia

119 rococcus Our findings unveil a heavy cost of promiscuous entry of generalist phages into nonhost cell

120 m during stress situations, in the form of a promiscuous enzymatic reaction in which the first enzyme

121 These findings contrast with simply promiscuous enzyme activities, which have been described

122 Selection for a promiscuous enzyme activity provides substantial opportu

123 Our results indicate that CPPase, a promiscuous enzyme, is more plastic toward acquiring new

124 mutagenesis and starting with the engineered promiscuous enzyme, MOMT5 (T133L/E165I/F175I/F166W/H169F

125 In contrast, CPPase is an inefficient promiscuous enzyme, which synthesizes the "irregular" mo

126 te that specific signaling can result from a promiscuous enzyme.

127 pertoire of glycan oligomers by partitioning promiscuous enzymes across multiple Golgi compartments.

128 nt insights suggest that non-specific and/or promiscuous enzymes are common and active across life.

129 Highly proficient, promiscuous enzymes can be springboards for functional e

130 ctional pathway can be patched together from promiscuous enzymes in the proteome, even without mutati

131 Proteases are multifunctional, promiscuous enzymes that degrade proteins as well as pep

132 4-step bypass pathway patched together from promiscuous enzymes that restores PLP synthesis in strai

133 chnological use implicit in the discovery of promiscuous enzymes.

134 diversity by predicting de novo reactions of promiscuous enzymes.

135 s an antenna that attracts TF molecules in a promiscuous exchange among myriads of intermediate affin

136 This enzyme is relatively promiscuous, exhibiting only 5-fold higher efficiency on

137 ls, into the contributions of an exceedingly promiscuous exportin and it provides a new basis for NES

138 Promiscuous expression of a plethora of tissue-restricte

139 R) signaling strength due to inefficiency in promiscuous expression of self-antigens or presenting a

140 The promiscuous expression of tissue-restricted antigens in

141 ted in the thymus to prevent autoimmunity by promiscuous expression of tissue-restricted self-antigen

142 females, and there were neither consistently promiscuous females nor males that consistently shared p

143 Photoexcitation of promiscuous flavoenzymes has thus furnished a previously

144 ffinis asparaginyl endopeptidase, OaAEP1, is promiscuous for incoming nucleophiles.

145 Here, we demonstrate that POMGNT1 is promiscuous for O-mannosylated peptides, whereas POMGNT2

146 Highly reactive and promiscuous fragments were rare and could be easily elim

147 We show that high levels of primary and promiscuous functions could have initially coexisted fol

148 , but some display constitutive activity and promiscuous G protein coupling.

149 RNA binding of the MA-HBR and inhibition of promiscuous Gag localization, both within the cells, and

150 ore, it is likely that MA-RNA binding blocks promiscuous Gag membrane binding in cells.

151 analysis for off-target effects indicated no promiscuous gene editing-mediated disruption.

152 Although the cellular mechanisms by which promiscuous gene expression (pGE) imposes T cell toleran

153 This promiscuous gene expression (pGE) is regulated in part b

154 To resolve mTEC diversity and whether promiscuous gene expression (PGE) is stochastic or coord

155 The results highlight that important promiscuous gene function may be missed when annotation

156 uencing of all patients allowed exclusion of promiscuous genotype-induced methylation calls.

157 nments with unpredictable risks may maintain promiscuous germination, which then affects flowering ti

158 ssay interference compounds (PAINS) or other promiscuous groups.

159 f-target edits were observed but only with a promiscuous guide RNA intentionally designed to validate

160 ted dsDNA binding and unwinding activity and promiscuous guide RNA specificity.

161 t of off-target rules to predict and exclude promiscuous guides.

162 direct attention toward the contribution of promiscuous halogenating enzymes in further expanding th

163 In contrast the more promiscuous Hhy also provided electrons to the cytochrom

164 TS) that reduced the rate of nonspecific and promiscuous hits and identified leads that inhibit human

165 omatic Coxiella infection (convalescents) to promiscuous HLA class II C. burnetii epitopes, providing

166 l paradox: if phosphatases are indeed highly promiscuous, how do cells insulate themselves against un

167 mino acids grips the substrate in a sequence-promiscuous, hydrophobic milieu.

168 nt ERK1/2 inhibitors reported along with the promiscuous hypothemycin (and related analogues) that ac

169 It is ubiquitous in distribution and promiscuous in function, with >50 putative peptide subst

170 st that while de novo ribozymes appear to be promiscuous in general, they are not obviously more prom

171 that the glycosyltransferase is surprisingly promiscuous in its substrate preferences.

172 sids do not necessarily colocalize; AAPs are promiscuous in promoting capsid assembly of other seroty

173 results demonstrate that TRPM3 is subject to promiscuous inhibition by Gbetagamma protein in heterolo

174 The third type consists of promiscuous inhibitory folds which resemble mouse traps

175 It also recovered known clades of site-promiscuous integrases and identified possible new ones.

176 The promiscuous inteins reported here thus improve the appli

177 The resulting "promiscuous" inteins are shown to be superior reagents f

178 The promiscuous interaction with non-native proteins generat

179 liquid phase separation (LLPS), whereby weak promiscuous interactions among RBPs and/or RNAs create a

180 racted with AtPam16s, the strengths of these promiscuous interactions are variable.

181 l diversity while limiting interference from promiscuous interactions in the crowded cellular environ

182 nterventions should target the migration and promiscuous interactions of cancer cells with the surrou

183 id-like aggregation but rather involves many promiscuous interactions.

184 fic structures is important so as to prevent promiscuous interactions.

185 This is facilitated by a series of promiscuous intermodule PKS-NRPS docking motifs possessi

186 Harnessing promiscuous intermolecular reactions of carbenoid compou

187 conserved among SULT1 family members and is promiscuous-it binds catechins, a naturally occurring fa

188 Compounds were derived from the promiscuous kinase inhibitor PP1 to search for analogs t

189 tain ortho-hydroxylated PBDE metabolites are promiscuous kinase inhibitors and can cause disruptions

190 Kinobeads are a set of promiscuous kinase inhibitors immobilized on sepharose b

191 lysine in a hydrophobic pocket to accelerate promiscuous Knoevenagel condensations of electron-rich a

192 unctions as an electron microscopy tag and a promiscuous labeling enzyme for live-cell proteomics.

193 lopment of strong and selective binders from promiscuous lead compounds represents one of the most ex

194 ith human PXR (hPXR) by interacting with its promiscuous ligand binding domain.

195 switch reveal that the likely basis for this promiscuous ligand binding is intrinsic structural adapt

196 ding underlines the highly collaborative and promiscuous ligand binding mechanism.

197 The mechanism underlying promiscuous ligand recognition and activation of FPRs is

198 akin to those of alphabetaTCRs but with more promiscuous ligand specificity trigger calcium flux.

199 opinion that microbial metabolite mimicry of promiscuous ligand-receptor interactions is warranted, a

200 We engineered a promiscuous ligase based on the NEDD8 conjugating enzyme

201 s in human cortical neurons, suggesting that promiscuous lipase inhibitors have the potential to caus

202 Both MTases yield promiscuous m6A modification of single strands, in the c

203 llenges this claim, however, contending that promiscuous male competitors and the risk of cuckoldry l

204 to promote male fertilization success under promiscuous mating.

205 closely related monogamous prairie voles and promiscuous meadow voles, and compare receptor densities

206 ested to function via frequently encountered promiscuous mechanisms of action including inhibition of

207 lution of specificity and reactivity between promiscuous members of clades of the alkaline phosphatas

208 rk, we model the selectivity of two multiply promiscuous members of this superfamily, namely the phos

209 TIMP2 is a promiscuous MMP inhibitor that is ubiquitously expressed

210 osphate groups binding to BRCT to understand promiscuous molecular recognition and guide inhibitor de

211 we addressed this challenge by converting a promiscuous natural human IgG-binding domain, the hypert

212 This promiscuous nature of Arg helps explain the increased pr

213 By using the promiscuous NmLgtB-B beta1-4 galactosyltransferase from

214 ium diphtheriae Cas9 (CdCas9) recognizes the promiscuous NNRHHHY PAM.

215 y and characterization of AmbO5 protein as a promiscuous non-heme iron aliphatic halogenase.

216 We find more promiscuous NR-DNA binding than has been reported, chall

217 The human pregnane X receptor (PXR) is a promiscuous nuclear receptor that functions as a sensor

218 The promiscuous nucleotidyl cyclase, exoenzyme Y (ExoY), is

219 ent phenomenon as an important mechanism for promiscuous oncogene activation and ultimately tumorigen

220 CC- or CXC-chemokines by a poorly understood promiscuous or "one-to-many" mechanism to neutralize inf

221 allow TrkA selectivity over TrkB and TrkC or promiscuous, pan-Trk inhibition.

222 Mycobacterium marinum is a promiscuous pathogen infecting many vertebrates, includi

223 The genome of this promiscuous pathogen is embedded with evidence of unprec

224 ar cells pulsed with 6 HER2-derived class II-promiscuous peptides via interferon-gamma (IFN-gamma) en

225 These results highlight promiscuous pharmacological influences on the serotonerg

226 drophilic group to interrupt the lipophilic, promiscuous pharmacophore and promote interaction with h

227 e-phosphorylate free d-ribulose generated by promiscuous phosphatases from d-ribulose 5-phosphate.

228 SsoPox exhibits promiscuous phosphotriesterase activity for the degradat

229 tructures of the MOBV relaxase MobM from the promiscuous plasmid pMV158 in complex with several origi

230 tion of MOBV histidine relaxases among small promiscuous plasmids and their preference toward Gram-po

231 Second, we design "promiscuous", polyspecific proteins against all binding

232 loss of type I receptor of TGF-beta triggers promiscuous, proinflammatory TGFBR2 signaling in SMCs, t

233 rtaining to mechanistic details of how these promiscuous proteins function remain outstanding, and th

234 rmation of the relative ion activity of this promiscuous pump.

235 primary and 10(9)- to 10(12)-fold for their promiscuous reactions, suggesting that catalytic promisc

236 Their high-energy, promiscuous reactivity profiles have hampered applicatio

237 an important role in cancer, however, their promiscuous reactivity, low abundance, and short-lived n

238 We also showed that this promiscuous receptor binding phenotype of RH5 was shared

239 provide a direct signal-processing role for promiscuous receptor-ligand interactions and establish o

240 Using specific examples of promiscuous receptor-ligand interactions, a case is made

241 pids, we define a new molecular mechanism of promiscuous recognition of common self-phospholipids inc

242 indicate that, in contrast to murine NAIPs, promiscuous recognition of multiple bacterial ligands is

243 line provides a molecular mechanism for this promiscuous recognition.

244 n complex prevents DNA damage signalling and promiscuous repair at chromosome ends.

245 germline integrity, which are both linked to promiscuous repeat transcription and gene expression.

246 network-based identification of an indirect promiscuous replacement of a key metabolic enzyme, which

247 h genome-scale metabolic modeling to predict promiscuous replacements via alternative metabolic pathw

248 y suppression, in which over-expression of a promiscuous 'replacer' gene rescues lethality caused by

249 itope in CFP-10 was identified but exhibited promiscuous restriction.

250 n as C2c2) exhibits a "collateral effect" of promiscuous ribonuclease activity upon target recognitio

251 erically activates the effector, typically a promiscuous ribonuclease.

252 miscuity and examine several cases of highly promiscuous ribozymes.

253 of PRC2-binding RNA motifs rationalizes the promiscuous RNA binding of PRC2, and their enrichment at

254 at enhancers may be a frequent by-product of promiscuous RNA polymerase initiation at accessible chro

255 human H1 promoter and demonstrated that this promiscuous RNA polymerase use can be exploited for the

256 f eukaryotic Thg1 from a family of ancestral promiscuous RNA repair enzymes to the highly selective e

257 in vivo and proteomics to achieve this in a promiscuous rodent, Myodes glareolus We show that, altho

258 ples of the intentional preorganization of a promiscuous scaffold along an atropisomeric axis to incr

259 Similar principles could apply to other promiscuous signaling pathways.

260 ha(q) protein in its latent cavity, allowing promiscuous signaling through both Galpha(s) and Galpha(

261 he active site of PIM1, and also at a second promiscuous site.

262 ial clades evolve from within a broader host-promiscuous species and sometimes target different niche

263 We find that the promiscuous species produces sperm with longer midpiece

264 howing that R-M systems are more abundant in promiscuous species, wherein they establish preferential

265 These findings point towards promiscuous spread of the mcr-1 gene by efficient horizo

266 , Srs2 dislodges Rad51 from ssDNA preventing promiscuous strand invasions.

267 ctivity assays that hybrid CDN-producing and promiscuous substrate-binding (Hypr) GGDEF enzymes are f

268 at transcription in 1-cell embryos is highly promiscuous, such that intergenic regions are extensivel

269 We show that EPR3 is promiscuous, suggesting that plants can monitor complex

270 ted nutrient milieus, which may underlie the promiscuous survival of T. gondii tachyzoites in diverse

271 Our group has previously defined several promiscuous T helper epitopes within the PvMSP1 protein,

272 XAV939 is a promiscuous tankyrase inhibitor and a potent inhibitor o

273 We conclude that profuse and highly promiscuous TC inputs to layer-4 fast-spike inhibitory i

274 Our results implicate positive selection for promiscuous TCRbeta sequences that likely evade negative

275 tate the design of new enzymes from existing promiscuous templates.

276 ects have shown that DNA binding is far more promiscuous than DNA cleavage, yet the molecular cues th

277 novo ribozymes would be quantitatively more promiscuous than later evolved ribozymes or protein enzy

278 uous in general, they are not obviously more promiscuous than more highly evolved or active sequences

279 RhoGAPs are more promiscuous than RhoGEFs to confine Rho activity gradien

280 xplains why the poxvirus resolvases are more promiscuous than RuvC, cleaving a variety of branched, b

281 All engineered Cas9s were less promiscuous than wild type when canonical gRNA was used,

282 Conversion of these intermediates by the promiscuous TPS SiTPS8 yielded different diterpenoid sca

283 ICP0 also functions as a promiscuous transactivator, and it blocks repressor comp

284 ome-wide surveys have uncovered evidence for promiscuous transcription across the entirety of the Kap

285 xt-dependent transcription factors, and that promiscuous transcription factor binding requires specif

286 In contrast, H3K56Ac represses promiscuous transcription that occurs immediately follow

287 sion, we report here that SaPIs ensure their promiscuous transfer by targeting conserved phage mechan

288 lved a fascinating mechanism to ensure their promiscuous transfer by targeting structurally unrelated

289 ted membrane electrophysiology, we find that promiscuous transport of hydrophobic substituted cations

290 sequence of this finding is an exceptionally promiscuous transporter: not only can EmrE export divers

291 ion for horizontal uptake and maintenance of promiscuous type III interference modules that supplemen

292 high tRNA charging fidelity to the otherwise promiscuous, unmodified enzyme.

293 omeres, which not only protects t-loops from promiscuous unwinding and inappropriate activation of AT

294 s indicate that the ability of CXCR6 to make promiscuous use of the available Gi/o proteins is exquis

295 We show that TurboID is the most promiscuous variant in several plant model systems and e

296 We propose that the abundance of promiscuous variants promotes the expansion and diversif

297 equently connected in sequence space to more promiscuous variants that can serve as intermediates dur

298 of various species, including monogamous and promiscuous voles.

299 prior in vitro results that showed GacA was promiscuous, we developed a full kinetic model combining

300 CTLMA2 intermolecular disulfide formation is promiscuous within this motif.