ライフサイエンスコーパス: promoter

1 al center (GC)-rich region of the PD-L1 gene promoter.

2 thylase Lsd1 to the fatty acid synthase gene promoter.

3 ing to a conserved E-box element at the IL-6 promoter.

4 ides "AAGT" at -4 to -1 positions of the DNA promoter.

5 he control of the Hfh4 (also known as Foxj1) promoter.

6 peratively transactivate the bICP0 early (E) promoter.

7 regulated ABSCISIC ACID INSENSITIVE3 (ABI3) promoter.

8 LZF, and GR had little effect on the bICP0 E promoter.

9 ranscription by binding upstream of the phoP promoter.

10 sses utilization of a co-oriented downstream promoter.

11 f the histone modifier HDAC1 at the Il9 gene promoter.

12 1 through PPARalpha binding sites within its promoter.

13 8) and P(bosR), and we focused on the native promoter.

14 tive TREs, physically interact with the Oct4 promoter.

15 nding of NF-[Formula: see text] to the Mef2c promoter.

16 SL1 dimers interact with RY elements at DOG1 promoter.

17 tes located 94 and 30 kb from the mouse Lef1 promoter.

18 ly SMARCB1, which upregulates the KSHV ORF50 promoter.

19 iptional repressor of the strong anti-CRISPR promoter.

20 n ERalpha AF-1-dependent estrogen-responsive promoter.

21 uired for Mediator association with the BCL6 promoter.

22 acilitated each other's binding to the hTERT promoter.

23 pressed behind the hair-cell specific Pou4f3 promoter.

24 which are essential for the activity of the promoter.

25 x 2 to induce bivalent chromatin at the Wapl promoter.

26 elopment, via direct binding to the Satb1 P2 promoter.

27 induction of NF-kB recruitment to the HEXIM1 promoter.

28 kb platelet derived growth factor B (PDGFB) promoter.

29 cytes under the control of the transthyretin promoter.

30 clear translocation and binding to the Axin1 promoter.

31 ption-competent preinitiation complex at the promoter.

32 the antibodies and a central bi-directional promoter.

33 e residual H3K27me3, compared to less-poised promoters.

34 mechanism by which ECT2 engages UBF1 on rDNA promoters.

35 itiate transcription at DNA sequences called promoters.

36 he transcription factor motif codes of their promoters.

37 genomic DNA prevents initiation from cryptic promoters.

38 hile oriP functions as an enhancer for these promoters.

39 that effectively distinguishes enhancers and promoters.

40 inds to TATT motifs unique to EBV late lytic promoters.

41 ese silencers forms long-range contacts with promoters.

42 s between ERalpha enhancers and their target promoters.

43 t for the development of novel wound-healing promoters.

44 s outperformed commercially used ie1 and ie2 promoters.

45 ctly binding to specific motifs within their promoters.

46 g the binding affinity of PvrA to its target promoters.

47 histone deacetylases-at active enhancers and promoters.

48 romoter element that is widely used in human promoters.

49 spectively, by specifically binding to their promoters.

50 ifically activate transcription of SM target promoters.

51 elements (CREs) in ER stress-responsive gene promoters.

52 uctures enriched at telomeres and oncogenes' promoters.

53 he recruitment of RNA polymerase II to their promoters.

54 histone H3 at lysine 27 (H3K27me3) at their promoters.

55 t correlations are observed within 200 kb of promoters.

56 between the +51 erythroid enhancer and TAL1 promoter-1 leading to inhibition of TAL1 expression in e

57 ne 4 (H3K4) trimethylation marks active gene promoters(6).

58 r respiratory factor 2 (NRF-2) to its target promoters, activating a subset of nuclear genes with rol

59 diffusion modelling and a spatially resolved promoter activation assay to study signal exchange in an

60 ghts into mechanisms orchestrating selective promoter activation in metabolic control and a model by

61 We provide evidence that the promoter activation rate is influenced by both enhancer

62 21(Cip1) gene promoter to suppress p21(Cip1) promoter activity and mRNA and protein level.

63 K1/2 pathway to repress PARK2 expression and promoter activity in melanoma cells.

64 The REV-ERB agonist SR9009 inhibited promoter activity of diverse HIV-subtypes and HIV-1 repl

65 OsNLA1 promoter activity was observed in roots, ligules, leaves

66 ibody, and flow cytometry to quantify GLP-1R promoter activity, gene expression, and protein expressi

67 aB, leading to the down-regulation of LINE-1 promoter activity.

68 ol II also maintains low poising at inactive promoters after major ZGA until the blastocyst stage, co

69 A version with dual convergent promoters allows enrichment of recombinant cells indepen

70 terestingly, the occupancy of MET on the Myc promoter also appeared in the compound mouse tumor sampl

71 Megakaryocytic gene-promoter analyses suggested that LEN-induced degradation

72 Promoter analysis suggests that the distinction between

73 NAP during initial transcription, in which a promoter-anchored RNAP uses a "scrunching" mechanism, ha

74 SiO(2) using triethanolamine as a dispersion promoter and characterized using aberration corrected sc

75 associated with repression of the antitoxin promoter and enhanced processing of its transcript, lead

76 ed in order for it to activate the HIV-1 LTR promoter and facilitate HIV-1 viral replication in the n

77 OGG1 without impairing its association with promoter and facilitated gene expression.

78 AGNET viral vectors containing a CaMKIIalpha promoter and microRNA-128 (miR-128) binding sites, and l

79 Next, we selected a constitutive SFFV promoter and NFkappaB binding sequence for bioluminescen

80 med direct binding of TCF/LEF factors to the promoter and putative enhancer regions of CSF3R.

81 3 histone marks on extracellular matrix gene promoters and active H3K4me3 marks on interleukin, defen

82 ing its expression through regulation of its promoters and by inhibiting its presentation through int

83 Motif activity analysis showed that both promoters and enhancers are activated by the same transc

84 While promoters and enhancers convey cell-type specific activa

85 i and safeguard the specificity of action of promoters and enhancers towards their targets in a tissu

86 uitment of RNA polymerase II (RNA Pol II) to promoters and enhancers.

87 nces would enable rapid generation of useful promoters and facilitate synthetic biology efforts in th

88 the sequence specificity of different viral promoters and identified positions 3, 5, and 8 of the pr

89 d cytosine-phosphate-guanines (CpGs) in gene promoters and other regulatory regions by specific demet

90 athogenic role for PAD enzymes in RA as both promoters and targets of the autoimmune response, as wel

91 expression is usually driven by pan-neuronal promoters and thus has not been selectively targeted to

92 ic errors, including cryptic sense/antisense promoters and translation, attenuation, incorrect start

93 herichia coli, under the control of the TPS1 promoter, and tested for complementation.

94 ifferential tau isoforms, expression levels, promoters, and disruption of endogenous genes in transge

95 n on shared promoters represents a composite promoter architecture, which can function both coordinat

96 nction, membership in protein complexes, and promoter architecture.

97 We discuss the influence of promoter architectures on decision times and error rates

98 Over half of human promoters are associated with CpG islands (CGIs), relati

99 matin interactivity-termed super-interactive promoters-are enriched for lineage-specific genes, sugge

100 ortant for Pol II to successfully escape the promoter as initiating complexes transition into elongat

101 consensus motifs of early and late ASFV core promoters, as well as a polythymidylate sequence determi

102 nd KLF15, but not KLF4, occupied the bICP0 E promoter at late times during productive infection of bo

103 RNA-mediated STAT3 or GLI1 knockdown reduced promoter binding of GLI1 and STAT3, respectively.

104 3.31 which is regulated by hypoxia via HIF-1 promoter-binding in multiple cell types.

105 inimum EBE was fused with a thymidine-kinase promoter but could be restored by fusion with the 100 bp

106 he dark and enhance PIF4 binding to the ABI5 promoter, but negatively regulate PIF4-mediated ABI5 act

107 vent stacking by re-transforming the stacked promoter:BvLz lines with additional BvLz expression vect

108 tes in the nucleus and activates the Sult1e1 promoter by recruiting phosphorylated ERalpha in the liv

109 y three RNA polymerases that are targeted to promoters by molecular complexes.

110 IRT induced transcription at cell-cycle gene promoters by recruiting FOXM1 through EZH2 to antagonize

111 subset of developmentally important bivalent promoters characterized by low expression and poised RNA

112 ing closed-to-open isomerization of the RNAP-promoter complex by compensating for the weak interactio

113 lysis revealed multiplex, activated enhancer-promoter configurations encompassing numerous multi-enha

114 under the control of a cytomegalovirus (CMV) promoter confirms autonomous genome replication in trans

115 ulation of SOCS2 and FLT3 through changes in promoter conformation.

116 CPs) in the cerebellum, as was shown in Jdp2-promoter-Cre transgenic mice.

117 drenergic-specific dopamine beta-hydroxylase promoter (DBH-hSNCA).

118 ion of CCL2 production by GPBAR1 agonism was promoter dependent and involved FOXO1.

119 from the full latency-associated transcript promoter did not efficiently prime gB-CD8s; however, gB-

120 In interphase cells, EBV promoters drive the expression of latency genes, while o

121 y activated astrocytes in the DMS using GFAP promoter-driven expression of hM3Dq, the excitatory DREA

122 strate that SM binds and recruits XPB to EBV promoters during lytic replication.

123 d divergently in hundreds of dual-initiation promoters during maternal to zygotic transition.

124 hat the DPR is a functionally important core promoter element that is widely used in human promoters.

125 holoenzyme required for engagement with -10 promoter element, although by a mechanism distinct from

126 LONGATED HYPOCOTYL5 (HY5) binds to the DEWAX promoter elements and represses its expression to promot

127 ack the previously identified canonical core promoter elements except for the Inr.

128 significant local overrepresentation of core promoter elements.

129 ve architectures for minimal synthetic plant promoters enabling the computational design of a suite o

130 ganize the structure of chromatin, including promoters, enhancers and insulators.

131 four times more likely to occur near active promoters, enhancers and transcribed regions.

132 Altered methylation in promoters, enhancers, and gene bodies, as well as in pol

133 analyses, we found that during prometaphase, promoters, enhancers, and insulators retain H3K4me3 and

134 lastocyst stage, coinciding with the loss of promoter epigenetic silencing factors.

135 on interleukin, defensin, and chemokine gene promoters, facilitating a rapid inflammatory response to

136 In bacteria, the best conserved promoter feature is the AT-rich -10 element; a sequence

137 These promoter features appear to correspond to cell-cycle-dyn

138 assay we found that the wild type hTERT core promoter folds into a stacked, three-parallel G-quadrupl

139 eir own and each other's super-enhancers and promoters, forming an inter-connected auto-regulatory lo

140 ion to the rrk1 promoter, we used new pol II promoters from endogenous coding genes to express crRNA

141 We previously generated promoter::GUS transgenic plants for all leucine-rich rep

142 Increased DNA methylation in Ppargc1a promoter had a fetal origin; elevated DNA methylation wa

143 d melanoma cell lines, suggest that the TERT promoter harbors a more complex mutational landscape tha

144 We find that inserted promoters have a wide range of gene-expression variabili

145 find that germline-active and soma-specific promoters have distinct features.

146 Greater understanding of gene silencing by promoter hypermethylation in anal carcinogenesis is need

147 Anal hrHPV and promoter hypermethylation in the cervix show promise as

148 c, TTS (transcription termination sites) and promoters; (iii) fourteen (14) genes associated with DBS

149 vealed the direct occupancy of USF2 at HOXA9 promoter in MLLr leukemia cells.

150 resolution dissection of more than a E. coli promoters in 12 growth conditions.

151 number of CGI-dependent characteristics with promoters, including statistically significant local ove

152 g WPGD1 and WPGD2 with an endosperm-specific promoter increased 6PGDH activity with enhanced heat sta

153 normoxia, CHD4 enrichment at HIF target gene promoters increased RNA polymerase II loading through p3

154 ion of fused-TADs promoting ectopic enhancer-promoter interactions that were likely to be involved in

155 ents suggest that the INR region of the GLI2 promoter is necessary for GLI2 repression.

156 The indica-type promoter is present in a progenitor subspecies O. nivara

157 e propose that global transcription at yeast promoters is responsible for eviction of H2A.Z.

158 o define +19-enhancer and the leukemic prone promoter IV interaction for TAL1 activation in T-ALL.

159 The spermatocyte-specific promoters lack the previously identified canonical core

160 of over 675,000 sequences in a constitutive promoter library and over 327,000 sequences in an induci

161 y and over 327,000 sequences in an inducible promoter library.

162 ripts, revealing roles for eRNAs in enhancer-promoter looping, recruiting transcriptional machinery,

163 rmediate states of yeast mtRNAP that explain promoter melting, template alignment, DNA scrunching, ab

164 ancer is mediated through differential SMAD3 promoter methylation in TAFs and provide new mechanistic

165 This results in deficits in promoter methylation of activity-dependent genes, as wel

166 MGMT promoter methylation status remained prognostic at tumor

167 This likely occurs via promoter methylation.

168 nterferon-stimulated response element (ISRE) promoter motifs, whereas the expanded set of type I IFN-

169 Correction of the -124C>T TERT promoter mutation to -124C was achieved using a single g

170 we evaluated 60 melanoma cell lines for TERT promoter mutational status, copy number, gene expression

171 Furthermore, the failure of TERT promoter mutations to consistently correlate with TERT e

172 Promoter occupancy of other CKM components generally mir

173 ll-autonomous signals to increase MYC level, promoter occupancy, and activity.

174 s, environmental enrichment (EE) is a potent promoter of AHN and hippocampal function.

175 C/EBPbeta binds the promoter of APOE and escalates its expression in the bra

176 We have identified a novel promoter of B. microti.

177 gulator of SRC kinase activation and a known promoter of cancer growth, fibrosis, and arthritis.

178 ivo assays showed that TubZIP28 bound to the promoter of cytosolic AGPase and enhanced both the trans

179 ce reporter system under the control of 4-kb promoter of human Klotho in stable HEK293 cells and in H

180 polynucleotides play the role of a modulator/promoter of LLPS in cells using computational methods.

181 PR-17 and site-specific SKN-1 binding to the promoter of nlp-24 to facilitate stress avoidance.

182 contacts of AEs with distant CTCF sites near promoter of other cell-cycle genes, which also become hy

183 evealed that BZR1 could directly bind to the promoter of RESPIRATORY BURST OXIDASE HOMOLOG 1 (RBOH1),

184 but in one tumor, HPV16 integrated into the promoter of the IFN regulatory factor 4 (IRF4) gene, whi

185 c-Myc binds to the promoter of the MTR4 gene and is important for MTR4 expr

186 ported using inexpensive SA as the catalytic promoter of the reaction.

187 chimeras under the control of the endogenous promoter of the respective LRR-RK leads to strong gain-o

188 This uncovered that FoxO1 binds to the promoters of 60% of cardiac-expressed genes at baseline

189 oteins and TRIM28 were specifically bound to promoters of active retrotransposons and to imprinting c

190 d transcription factor binding motifs in the promoters of cell type-specific genes.

191 computational design of a suite of synthetic promoters of different strengths.

192 ved allele frequency, and were depleted from promoters of essential genes, which is consistent with t

193 ed OGG1 activity, 8-oxoG accumulation at the promoters of genes critical for brain function, and tran

194 on as a transcription factor, BFD1 binds the promoters of many stage-specific genes and represents a

195 dox by showing that these enzymes are strong promoters of microtubule growth.

196 eneral transcription factors assemble on the promoters of mRNA genes to form large macromolecular com

197 e PIF proteins at their binding sites in the promoters of PIF Direct Target Genes (DTGs).

198 l MYB recognition elements were found in the promoters of TBT, DBTNBT and TS.

199 tone valleys are found to be enriched at the promoters of the developmentally associated genes.

200 tation and whether located in a heterologous promoter or intron.

201 did not drive the transcription of the IL10 promoter or putative local enhancer constructs.

202 ynergy depends on the presence of the active promoter/origin.

203 -induced activity of SfHsp20.71 and SfHsp70D promoters outperformed commercially used ie1 and ie2 pro

204 omoter (Ptrc-cfrA) or the arsenite-inducible promoter P (arsB) (Pars-cfrA).

205 nscription of the entire operon and a second promoter (P (mer) ), located within merR, is responsive

206 An upstream promoter, P (oah) , controls the constitutive transcript

207 bosR transcription is driven by two promoters, P(bb0648) and P(bosR), and we focused on the

208 Hence, we hypothesized that DRB gene promoter polymorphism might lead to altered DRB gene exp

209 tivating cells associated with each of for's promoters (pr1-pr4), we show that pr1 cells regulate lar

210 Promoter-proximal and premature termination is common an

211 , impairs CEBPB's association with its Cebpa promoter-proximal binding site during adipogenesis.

212 I on alpha genes accumulated most heavily at promoter-proximal pause (PPP) sites located ~60 nucleoti

213 o allow recruitment of Pol II and entry to a promoter-proximal paused state, and also to promote Pol

214 n late in infection is mediated by prolonged promoter-proximal pausing.

215 cent capped piRNA precursors associated with promoter-proximal Pol II, resulting in termination of tr

216 or the Integrator complex as a terminator of promoter-proximal RNA polymerase II during piRNA biogene

217 and the CTR, and promotes redistribution of promoter-proximally paused Pol II into gene bodies.

218 Efficient release of promoter-proximally paused RNA Pol II into productive el

219 ng CfrA from either the constitutive P (trc) promoter (Ptrc-cfrA) or the arsenite-inducible promoter

220 bacteria are especially amenable because the promoter recognition and melting steps are much less com

221 and extends RNA without displacement of the promoter recognition sigma factor from the core enzyme.

222 oides, we identified a surprising feature of promoters recognized by the major holoenzyme.

223 s transition from H3K27me3 to H3K27ac at the promoter, recruits the C/EBPbeta (CREB-binding protein)

224 As cells exit mitosis, promoters regain H3K27ac, which correlates with transcri

225 re, we found enrichment of KLF4 at the S18-2 promoter region and that the S18-2 expression is positiv

226 ulated by AP-2gamma through binding with its promoter region in luminal breast cancer cell lines and

227 YAP/TAZ bind to the promoter region of FOS to stimulate its transcription.

228 ion with the TEA domain-binding motif in the promoter region of inflammatory cytokines.

229 d to elevated H3 lysine 9 acetylation on the promoter region of miR-1185-1, which increased expressio

230 ication, and bound to the KSHV genome in the promoter region of ORF50, increasing its transactivation

231 e, the mutations TR34 and TR46, found in the promoter region of the gene encoding the azole target cy

232 factor downstream from MEK/ERK, binds to the promoter region of VE-cadherin (chip assay) and is induc

233 two XBP-response elements (XRE) on the ORF21 promoter region.

234 5% CI 12.7%-16.8%) in both katG and the inhA promoter region.

235 preference for transcription start site and promoter regions and a large number of active enhancers

236 ion of gene expression enabled by tiling the promoter regions of all 969 genes that comprise the ito9

237 Examination of the promoter regions of all genes involved in heparin/hepara

238 DNA methylation at the INSR and IGF2 gene promoter regions was detected by the Sequenom's MassARRA

239 sed fathers, especially at dopamine receptor promoter regions, suggesting that epigenetic modificatio

240 , TYMS and TK1 expression and binds to their promoter regions.

241 Based on these promoters, regulatory networks of higher complexity are

242 restin-2 forms "infinite" chains, where each promoter remains in the basal conformation.

243 We propose that dual-initiation on shared promoters represents a composite promoter architecture,

244 d in the absence of exogenous carcinogens or promoters requires a two-field composite consisting of a

245 In mice, the epitope expressed from the gB promoter restored full gB-CD8 immunodominance to 50%.

246 and identified positions 3, 5, and 8 of the promoter sequence as essential to the in vitro RSV polym

247 Here we report that promoter sequence changes upstream of the site of transc

248 rather than any single regulatory factor or promoter sequence motif.

249 ermore, we were able to identify a number of promoter sequence motifs associated with leaf senescence

250 ing enhancer function, and confirm that core promoter sequences are necessary for this activity.

251 lymorphic transposable element insertions in promoter sequences contributed to the high level of cis

252 t accurately predict protein expression from promoter sequences would enable rapid generation of usef

253 tion rate is influenced by both enhancer and promoter sequences, whereas Pol II loading rate is prima

254 Promoters serve a critical role in establishing baseline

255 etween healthy and failed hearts highlighted promoter shifts which altered aminoterminal protein sequ

256 ncreatic cells, gene ontology analyses of DM promoters show an enrichment for genes involved in diffe

257 accumulation achieved with the combinatorial promoter stacking expression system was stable in multip

258 KLF4-mediated transactivation of the bICP0 E promoter, suggesting that a novel mechanism exists for t

259 en the act of transcription from an upstream promoter suppresses utilization of a co-oriented downstr

260 Furthermore, TCF1 regulates the Satb1 P2 promoter switch during CD4SP development, via direct bin

261 oncogene Tax, driven by the human granzyme B promoter (Tax(+)), develop osteolytic tumors.

262 PIF3(K13R) binds more strongly to the target promoters than its SUMOylated, wild-type counterpart.

263 immediate early transcription unit 1 (IEtu1) promoter that drives bovine infected cell protein 0 (bIC

264 tor (GR) stimulates productive infection and promoters that drive expression of key viral transcripti

265 bind certain DNA recognition motifs in gene promoters that regulate gene expression.

266 a two-authentication system mobilizes a gene promoter through a dynamic network of polymeric nuclear

267 ndothelial-specific receptor tyrosine kinase promoter Tie2.

268 ere high, HIF1alpha interacted with the Cd36 promoter to augment expression and enhance fatty acid up

269 ent recruitment of NF-kappaB to the A3B gene promoter to drive A3B expression.

270 s on channel gating using a Ca(2+)-sensitive promoter to express a secreted embryonic alkaline phosph

271 e tested this model using the inducible GAL1 promoter to make the Whi5 concentration independent of c

272 DNA response elements in the p21(Cip1) gene promoter to suppress p21(Cip1) promoter activity and mRN

273 s and TREs physically interact with the Oct4 promoter to varying degrees; specifically, a greater num

274 x genomes, facilitate accurate assignment of promoters to genes and easily identify transcriptionally

275 ne regulation relies on the capacity of gene promoters to integrate inputs from distal regulatory ele

276 ET and HiChIP loops as well as loops linking promoters to regulatory elements.

277 ain how specific interactions controlled the promoters' transcription rates.

278 Comparing promoter usage between healthy and failed hearts highlig

279 or that preferentially binds an unmethylated promoter used in the reporter assays.

280 omain of TET1 to dCas9 targeted to the CDKL5 promoter using three guide RNAs causes significant react

281 bound transcription factors to their target promoters using a novel computational algorithm, target

282 While TET1 binds to CpG dinucleotides in promoters using its CXXC domain, TET1 also binds to enha

283 ial regulatory functions by interaction with promoter vG4s.

284 the same promoter, we can determine when the promoter was active.

285 A bisulfite sequencing revealed that the Tnf promoter was hypermethylated in tumor-induced MDSCs in v

286 multiple timestamped RNAs driven by the same promoter, we can determine when the promoter was active.

287 in (GFP) under an interferon-stimulated gene promoter, we repeatedly observed transgenic larvae spont

288 In addition to the rrk1 promoter, we used new pol II promoters from endogenous c

289 Despite the lack of human-like TERRA promoters, we clearly detected TERRA expression originat

290 phloem specific SUCROSE SYNTHASE 2 (AtSUC2) promoter were developed.

291 rRNA promoters were activated by purified R. sphaeroides CarD

292 matin states were differentially methylated, promoters were less methylated than repressed regions (P

293 e find that at least eight TFs bind the IME1 promoter when nutrients are ample.

294 d in reiterative transcription from the pyrG promoter, which contains eight poly-G RNA bases synthesi

295 lncRNA-MAP3K4 shares a bidirectional promoter with MAP3K4, an upstream regulator of the MAPK

296 In both cell types, promoters with high basal H3K4me2/3 activate in spite of

297 In addition, promoters with increased levels of chromatin interactivi

298 ions by measuring Cbf1p binding at synthetic promoters with multiple sites.

299 dependently, MYC increased output at minimal promoters with or without an E-box.

300 d a temporal hierarchy of TF binding to gene promoters within the same family as well as across diffe