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1 ssemble the nuclear envelope between the two pronuclei.
2 arental genomes are enclosed in two separate pronuclei.
3 onuclei is already lower than that in female pronuclei.
4 on was abrogated by deletion of Tet3 in both pronuclei.
5 tion as determined by an irregular number of pronuclei.
6  polar body, resulting in formation of three pronuclei.
7 ents leads to embryonic lethality with small pronuclei.
8 cle timing between the paternal and maternal pronuclei.
9 elocalizes to the developing male and female pronuclei.
10 of WAVE1 and the migration and apposition of pronuclei.
11 us control region was injected into B6CBA/F1 pronuclei.
12 r movement and premitotic positioning of the pronuclei.
13  5mC levels decreased in the mutant maternal pronuclei.
14 M resulted in a decrease of H3R2me2s in male pronuclei.
15 tition the parental genomes contained in two pronuclei.
16 erated by normal fertilization by the late 2 pronuclei (2PN) stage.
17 rieved was 20 (14-28), fertilized oocytes (2 pronuclei [2PN]) was 11 (7-17), usable embryos was 6 (3-
18 y compacted form into decondensed, spherical pronuclei, accompanied by rapid nucleation of microtubul
19                 At first interphase, apposed pronuclei align obliquely to the animal-vegetal axis aft
20 are initially distributed loosely around the pronuclei and the cytoplasm are relocated around the mit
21 ase exit is evidenced by the failure to form pronuclei and the persistence of phosphohistone H3 and M
22 aused asynchrony between the male and female pronuclei and, ultimately, loss of paternal chromosomes
23 cytes (growing, GV-stage, and MII-arrested), pronuclei, and polar bodies.
24 associations between the sperm aster and the pronuclei are essential during this directed movement.
25                                  However, if pronuclei are formed in the presence of exogenous CTCF,
26 ion and incidental modifications in parental pronuclei are specified by LSM1-dependent pericentromeri
27 eless, unfertilized embryos assembled female pronuclei at the same time as fertilized embryos.
28                Here we show that transfer of pronuclei between abnormally fertilized human zygotes re
29                           In oocytes with no pronuclei but with low M-phase kinase activity, sperm-in
30 c cortex-microtubule interactions among male pronuclei, centrosomal microtubules, and the animal pole
31                                           In pronuclei, chromatin compartmentalization increases, but
32 yos with > 10 cells, high-quality embryos, 2-pronuclei cleavages, and a menopause-related age metric.
33 ones in the egg, the early embryo equivalent pronuclei, cultured somatic cells, and erythrocytes.
34 clear envelopes of the maternal and paternal pronuclei disassemble, allowing both sets of chromosomes
35                              Parthenogenetic pronuclei drift centripetally and assemble astral spindl
36 tes at the germinal vesicle stage and in the pronuclei during fertilization.
37 r envelopes at the interface between the two pronuclei during the first mitotic division.
38                We observed that the maternal pronuclei expanded in size in the mutant zygotes and con
39  As a result, polar bodies are not produced, pronuclei fail to form, and cytokinesis does not occur.
40 , and possibly other organisms, when the two pronuclei first meet, the parental genomes are separated
41                                     Distinct pronuclei form and DNA replication initiates, but the ma
42 ite Golgi fragmentation after BFA treatment, pronuclei form and unite, and embryos cleave and develop
43  in efficient H2B incorporation and paternal pronuclei formation.
44 se eggs, chromatin remained condensed and no pronuclei formed.
45 nd polar bodies (PB1 and PB2) and the oocyte pronuclei from same female egg donors, we phase the geno
46 unction, where the four membranes of the two pronuclei fuse and become two.
47 mechanisms that control how the two parental pronuclei fuse in the first mitosis of the embryo are po
48 he male pronucleus (mh, K81, and pal or both pronuclei (gnu, png, and plu).
49 s of time-lapse images showed that as mutant pronuclei grew in surface area, they captured detached c
50 croinjection of recombinant DNA into zygotic pronuclei has been widely used for producing transgenic
51 Pramel15 elevates DNMT1 levels in the zygote pronuclei, impairs zygotic DNA demethylation, and causes
52 m and MII oocytes is largely erased in early pronuclei in a protamine phosphorylation-dependent manne
53 c-family PTKs became concentrated around the pronuclei in close association with the nuclear envelope
54 whose sperm can be assembled into functional pronuclei in egg extracts in vitro.
55        We followed the loss of macroH2A from pronuclei in parthenogenetic embryos generated by oocyte
56      Active PKCzeta also is enriched in both pronuclei in the 6-h post-fertilization and in the 14-h
57 ant and act in concert to unite the parental pronuclei in the zygote's centre.
58 ng upon fertilization, we reconstituted male pronuclei in Xenopus egg extracts.
59 oocyte, egg, sperm, early embryo equivalent (pronuclei incubated in egg extract), S3 neurula cells, A
60            The mechanisms that then move the pronuclei inwards for their unification are only poorly
61 ge the genome-wide methylation level in male pronuclei is already lower than that in female pronuclei
62  at metaphase, the interface between the two pronuclei is composed of two membranes perforated by fen
63 ttachment to the surface of abnormally small pronuclei is dynein.
64 ge level of carry-over after transfer of two pronuclei is less than 2.0%, with many of the embryos co
65 ar envelope breakdown (NEBD) of the parental pronuclei is spatially and temporally regulated during m
66                                       How do pronuclei migrate towards each other?
67 rientation of polarity proteins, P granules, pronuclei migration and asymmetric cell division.
68 osomes first become enclosed in two separate pronuclei near the surface of the fertilized egg.
69                                Transplanting pronuclei of fertilized Drp1 knockout oocytes to normal
70 e protocol is based on co-injection into the pronuclei of fertilized oocytes of synthetic mRNA encodi
71  binding sites for the transposase, into the pronuclei of fertilized oocytes.
72 smid-encoded reporter gene into the paternal pronuclei of one-cell embryos at a specific histone-DNA
73 s repression are not present in the paternal pronuclei of one-cell mouse embryos but are present in t
74  genomic DNA construct was injected into the pronuclei of rabbit embryos.
75 ed in targeting embryonic stem cells and the pronuclei of single-celled embryos.
76 activities with reduction of H3R2me2s in the pronuclei of zygotes.
77 croH2A is associated exclusively with female pronuclei prior to loss in late pronucleus stage embryos
78  alternative approach based on transplanting pronuclei shortly after completion of meiosis rather tha
79 g MII were unable to progress beyond the two pronuclei stage following in vitro fertilization (IVF).
80  one centrosome was captured by small female pronuclei, suggesting the mechanism of capture is depend
81 arger tetraploid or smaller histone::mCherry pronuclei suppressed or enhanced the centrosome detachme
82 d have different effects on the formation of pronuclei, the first cleavage of zygotes, the developmen
83                   During migration of intact pronuclei, the parental genomes polarize toward each oth
84 after abnormal oocyte meiosis and failure of pronuclei to fuse.
85 pha translocates from the cytoplasm into the pronuclei to sites of active transcription.
86 relative capacities of paternal and maternal pronuclei to transcribe genes, and the requirements for
87 leus, or in migration of the male and female pronuclei toward each other.
88 embles that slowly moves the male and female pronuclei towards the cell centre in a dynein-dependent
89 mbly of the nuclear envelope between the two pronuclei, ultimately allowing intermingling of the mate
90               Mitochondrial association with pronuclei was positively related with embryo development
91 tiers formed from the caudal domain and most pronuclei were defined, which were modified into the def
92 th defects in the nuclear envelope had small pronuclei with a single centrosome detached from the mal
93 al concentrations on the nuclear envelope of pronuclei with detached centrosomes.
94 ternal CENP-A decreases total CENP-A in both pronuclei without disrupting equalization.
95 ecreased mitochondrial association with male pronuclei without having an apparent effect on microtubu