1 and pace to make their operations 'pandemic
proof'.
2 The two key tools in our
proof are the holomorphic projection of products of thet
3 Validity was
proofed by precision (>96%), accuracy (95% - 103%) and r
4 However, direct
proof for this theory is still lacking.
5 resisted various attempts to find bijective
proofs for almost 40 y is concerned with alternating sig
6 Proof is provided that statin-mediated cholesterol deple
7 unamplified cDNA) had to be replaced by (3)
proofing linear pre-amplification for each gene, thus, i
8 ysis of nine cases of COVID-19 that provides
proof of active virus replication in tissues of the uppe
9 To demonstrate
proof of concept and estimate effect size, we performed
10 sign is verified using a breadboard and FPGA
proof of concept circuit and passes all 15 of the NIST r
11 This study demonstrates the
proof of concept for 1D and 2D NMR methods in the target
12 Gonda and colleagues provide preclinical
proof of concept for a new therapeutic strategy and addr
13 We present a
proof of concept for a spectrally selective thermal mid-
14 Therefore, our results offer a
proof of concept for an alternative treatment to chemoth
15 bocyclic nucleoside analogues and provided a
proof of concept for application as inhibitors for the p
16 otics alone.CONCLUSIONThis study establishes
proof of concept for exebacase and direct lytic agents a
17 This work provides a
proof of concept for fundamental catalytic action of the
18 Mecp2 p.R294X mutation in vivo and provide a
proof of concept for future preclinical studies of nonse
19 ak of the current conflict, and they provide
proof of concept for how geospatial techniques can be us
20 Findings provide
proof of concept for MPI insertion in the clinical biops
21 Proof of concept for OSPW source identification using di
22 As a
proof of concept for super-resolution applications, we u
23 oid-mediated immune suppression and provides
proof of concept for targeting this pathway for tumor im
24 iated osteomyelitis, and then we validated a
proof of concept for the lateral flow assay (LFA).
25 The data here reported constitutes the first
proof of concept for the potential application of the pe
26 Our initiative offers a
proof of concept for the repurposing of existing approac
27 Previous studies served to demonstrate the
proof of concept for the use of quantum confined semicon
28 These results provide a
proof of concept for understanding age-related vascular
29 More broadly, this research demonstrates a
proof of concept for using remote sensing to detect forc
30 The
proof of concept herein points to a mechanistic basis fo
31 A
proof of concept is conducted by using the LoTToR on a p
32 The
proof of concept is demonstrated by detecting different
33 A
proof of concept is shown using a ketone mixture introdu
34 unprecedented transformation, albeit at the
proof of concept level, offers a new approach toward a c
35 We use a computational approach to propose a
proof of concept model showing that a single, simple net
36 As a
proof of concept of its manufacturability, biocompatibil
37 These findings serve as
proof of concept of synergistic antitumour activity with
38 Thus, this study established the
proof of concept of targeting TF as a new target in CAR-
39 Here, we first present an experimental
proof of concept on a tissue-mimicking phantom and then,
40 The
proof of concept reported here is the first step toward
41 last two decades, the field has grown from a
proof of concept stage to a broad range of methods for a
42 This
proof of concept study demonstrates that mD-LC/MS has th
43 This
proof of concept study targets the translational rigor o
44 ure (IdeS digestion x reduction-HILIC/MS), a
proof of concept study using two mAbs is described here.
45 The
proof of concept that an enantioselective version of thi
46 These results provide an experimental
proof of concept that changes in locomotor behaviour and
47 rapeutic resistance, but they also provide a
proof of concept that targeted inhibition of this axis m
48 tiple tumor-relevant promoters, we provide a
proof of concept that the system can implement logic gat
49 of this study was to perform a preclinical "
proof of concept" study of Bergamot polyphenolic formula
50 As a
proof of concept, a rapid assay consisting of a cell-bas
51 As a
proof of concept, aflatoxins, ochratoxin A, and deoxyniv
52 As a
proof of concept, botanical samples were digested by MIC
53 As a
proof of concept, eighteen essential amino acids at phys
54 As a
proof of concept, in situ separation and imaging of lipi
55 As
proof of concept, industrial wastewater was investigated
56 The robustness, shown using strychnine as a
proof of concept, makes the J-based CASE-3D analysis a v
57 Exemplarily, as
proof of concept, one nontarget pollutant was identified
58 As
proof of concept, results showed that INSeq screens succ
59 experimental data and DFT calculations, as a
proof of concept, the capacity to utilize the Mn-MOF for
60 Eventually, as a
proof of concept, the designed biosensor was successfull
61 As a
proof of concept, the obtained CeO(2) -based SOMMs show
62 For a
proof of concept, the technology platform was tested wit
63 As a
proof of concept, this (13)C NMR dereplication strategy
64 As a
proof of concept, various Int derivatives have demonstra
65 As
proof of concept, we applied FLEXIQuant-LF to data-indep
66 As a
proof of concept, we characterized the function of the h
67 As a
proof of concept, we developed a 5-plex assay measuring
68 As
proof of concept, we functionalized 47 missense variants
69 As a
proof of concept, we have used this CRISPR-E test in the
70 As a
proof of concept, we investigate the Ras-Raf system, a w
71 As a
proof of concept, we performed digital LAMP on a sp-Slip
72 As a
proof of concept, we propose herein to monitor the photo
73 For
proof of concept, we select the gastrointestinal drug me
74 Applying our framework to Germany as a
proof of concept, we show significant losses in function
75 For
proof of concept, we tested PNAs targeting miRNA-155 and
76 ssels from Cav-1(-/-) mice were used to test
proof of concept.
77 Five of 7 patients had subsequent
proof of COVID-19 by reverse-transcriptase polymerase ch
78 Proof of efficacy awaits randomized, placebo-controlled
79 om an arboreal ancestral species rather than
proof of engagement in arboreal activities during life.
80 otrophic lateral sclerosis (ALS), but actual
proof of hyperexcitation in vivo is missing, and trials
81 he in vivo evaluation of (18)F-FAPI-74 and a
proof of mechanism for (68)Ga-FAPI-74 labeled at ambient
82 A] and TS-134) were assessed in two Phase Ib
proof of mechanism studies of comparable designs and usi
83 symptoms and epileptic seizures for further
proof of pathogenicity.
84 It should be noted that, this is just a
proof of principal that, images can also be used as a me
85 We offer
proof of principle and a versatile framework.
86 , some are established, whereas others are a
proof of principle and have not yet been applied to envi
87 This
proof of principle case can stimulate future mechanistic
88 HPMs perform promisingly in these
proof of principle experiments.
89 These results provide
proof of principle for a novel strategy in developing hi
90 This study provides a
proof of principle for a strategy to create protein-leve
91 lectively, these results provide therapeutic
proof of principle for FEN1 blockade in tamoxifen-resist
92 Our results provide important
proof of principle for Gcn5 functions in formation and p
93 We provide
proof of principle for immunologically targeting AML-ini
94 Taken together, this work offers a
proof of principle for the design of a gene drive in vir
95 In addition,
proof of principle has been demonstrated for the dynamic
96 We aimed to develop a
proof of principle mechanistic machine learning model th
97 Our
proof of principle model successfully predicted the dail
98 Proof of principle now exists that major photoprotective
99 As a
proof of principle of a future vector saliva-based pan-L
100 As a
proof of principle of its activity, 1 was used as a prec
101 Thus, our results provide
proof of principle that D/N Vif variants could have ther
102 ry analyses of randomized trial data provide
proof of principle that inflammation inhibition, at leas
103 These results provide a
proof of principle that quantitative, high-resolution im
104 The PLCA is also applied as a
proof of principle to a previously published gut microbi
105 on network and gene regulatory network, as a
proof of principle to identify heterogeneous interactome
106 We offer
proof of principle using simulations based on functional
107 These studies provide "
proof of principle" that targeting CDK6 with PROTACs tha
108 As
proof of principle, the effects of hydrophobic (e.g., es
109 As a
proof of principle, this manuscript investigates the com
110 As a
proof of principle, we applied this approach to the mala
111 As a
proof of principle, we apply torsional forces to a coars
112 As
proof of principle, we compared trastuzumab conjugated t
113 As a
proof of principle, we demonstrated that SimCells can be
114 As
proof of principle, we document over a million new names
115 As a
proof of principle, we employed (4,6-O-benzylidene)methy
116 As
proof of principle, we have quantified an endogenous pep
117 As a
proof of principle, we show that our method can accurate
118 As a
proof of principle, we tested our model in an allogeneic
119 As
proof of principle, we verify candidate fSNPs on three w
120 ting the Ras dimerization hypothesis, direct
proof of Ras dimerization is still inconclusive.
121 As
proof of the concept, vascularized cardiac constructs ar
122 This
proof-
of principle study provides valuable probes for NT
123 ation and activity of Rab11b, and we provide
proof-
of principle that these drugs prevent breast cance
124 We used our approach in
proof-
of-concept "synthetic" in silico experiments, in w
125 nditions, and a drop-off of efficacy between
proof-
of-concept (i.e., Phase II trials) and pivotal, co
126 Proof-
of-concept ambient measurements were performed in
127 S binding signals were detected, prompting a
proof-
of-concept analysis of human serum samples.
128 Our data provide an important
proof-
of-concept and model system for the potential use
129 In a
proof-
of-concept application, we isolated bacteria from
130 As
proof-
of-concept applications, we used the octapeptide t
131 In a
proof-
of-concept approach, we explored a clinically tran
132 We demonstrated
proof-
of-concept based on detection of "activated" matri
133 The
proof-
of-concept battery delivers reasonable electrochem
134 The
proof-
of-concept bioelectronic devices include electroph
135 We provide a
proof-
of-concept by using SOLVING to quantitate the orie
136 ighly advantageous group in which to conduct
proof-
of-concept clinical trials that target tau-related
137 evidence is now leading to the initiation of
proof-
of-concept clinical trials using senolytics for se
138 Our findings provide
proof-
of-concept data for engineering patient-specific j
139 volved only a small cohort, these meaningful
proof-
of-concept data now warrant further investigation
140 This study provides
proof-
of-concept data supporting the use of complex coac
141 Here, we report a novel strategy with
proof-
of-concept data that supports the usage of loop-me
142 We provide a
proof-
of-concept demonstration in the GEDmatch database,
143 As a
proof-
of-concept demonstration, the permeability of endo
144 ing process(5), which-although versatile for
proof-
of-concept demonstrations(6-16) and fundamental st
145 The
proof-
of-concept device has 20 sensors and a 45-degree f
146 Here, we report a direct coupled,
proof-
of-concept electrochemical system that uses a bipo
147 We then use the model in a
proof-
of-concept example.
148 In a
proof-
of-concept experiment using this technology in an
149 As a
proof-
of-concept experiment, we demonstrate a functionin
150 Finally, we report the
proof-
of-concept experiment, where detection sensitivity
151 Proof-
of-concept experiments showed that the presence of
152 Our goal in this study is to provide a
proof-
of-concept for a non-invasive assay of global mole
153 Our results provide
proof-
of-concept for a paradigm of microbially-derived b
154 em and method presented showcase a promising
proof-
of-concept for granting an exclusively light-trigg
155 alence among GBM with HIV-infection provides
proof-
of-concept for HCV micro-elimination.
156 ing from experimental data, and we provide a
proof-
of-concept for how they could form the basis of a
157 Our results offer a
proof-
of-concept for modifying synthetic nanogels with a
158 As
proof-
of-concept for the discovery of novel P2X receptor
159 Here, we establish a
proof-
of-concept for the molecular sieving separation of
160 These results provide the first
proof-
of-concept for the usage of low-power light source
161 In a
proof-
of-concept human study on the therapeutic, we foun
162 Application of the
proof-
of-concept illustrated here, using a feedback loop
163 This work may provide a
proof-
of-concept in developing technically and economica
164 Herein, we report
proof-
of-concept in vivo efficacy in an streptozotocin-i
165 Subsequent
proof-
of-concept in vivo studies demonstrated that, when
166 evidenced by the preliminary results from a
proof-
of-concept in-vivo experiment of tracking an indiv
167 Two
proof-
of-concept inorganic probes that exploit a novel m
168 A
proof-
of-concept material in a cantilever setup is used
169 aterial is reported, using Mg(2) TiO(4) as a
proof-
of-concept material.
170 n of sunscreen products for an FDA-sponsored
proof-
of-concept maximal usage clinical trial.
171 We present a
proof-
of-concept method to infer the total tumour pressu
172 Our goal was to develop a
proof-
of-concept model for identifying subjects at high
173 These
proof-
of-concept observations offer a promising step tow
174 Here we present
proof-
of-concept of a biological self-restoring system t
175 The results represent a
proof-
of-concept of a new algorithm of personalized anti
176 egies may be safe and effective and provides
proof-
of-concept of a potential strategy that may allow
177 f biotinylated glucose oxidase (biot-GOx) as
proof-
of-concept of the analytical application of MWCNTs
178 Preliminary results suggest
proof-
of-concept of using the ECochG response as a micro
179 This work demonstrates a
proof-
of-concept responsive drug-release system that may
180 Herein, we report
proof-
of-concept results on a versatile synthetic strate
181 The
proof-
of-concept scheme consists of a spinning core made
182 In addition, studies using the
proof-
of-concept small molecule inhibitors of ICMT confi
183 assifier was integrated with the device as a
proof-
of-concept so that sensor's response can be traine
184 ibrary of 250 DNA parts and assemblies and a
proof-
of-concept strain that illustrates cAMP-chemotaxis
185 We report a
proof-
of-concept structured light generation experiment,
186 ency, solubility, and lipophilicity to allow
proof-
of-concept studies in mice.
187 These
proof-
of-concept studies indicate that alphaDR5-NPs load
188 , and perform extensive characterization and
proof-
of-concept studies of mSncg promoter-mediated gene
189 electrode materials, application of scalable
proof-
of-concept studies, and acknowledgment of all trea
190 Collectively, this
proof-
of-concept study demonstrates that empowering pati
191 This work represents a novel
proof-
of-concept study demonstrating the feasibility of
192 C compared with liver tissue, we conducted a
proof-
of-concept study evaluating the efficacy of 3'-deo
193 This
proof-
of-concept study has demonstrated that hyperpolari
194 Overall, this
proof-
of-concept study has supported the development of
195 This
proof-
of-concept study holds promise as a novel immunoth
196 This single-center retrospective
proof-
of-concept study included 32 patients with documen
197 epare and to subsequently perform a clinical
proof-
of-concept study on the general suitability of sil
198 This
proof-
of-concept study presents Raman hyperspectroscopic
199 Collectively, this
proof-
of-concept study provides a first example of photo
200 Our
proof-
of-concept study provides a powerful new methodolo
201 This positive
proof-
of-concept study supports the continued developmen
202 We demonstrate in a
proof-
of-concept study that Ce6-PVP-based fluorescence e
203 Here, we present a
proof-
of-concept study to noninvasively derive the therm
204 Methods: In this
proof-
of-concept study, 11 patients with lymphoma of the
205 ) and investigated on clinical isolates as a
proof-
of-concept study, but requiring longer incubation
206 Conclusion In this
proof-
of-concept study, percentage of T1 shortening at e
207 In this
proof-
of-concept study, we included people living with H
208 Based on this first
proof-
of-concept study, we propose multi-scale phase con
209 Conclusion: In this
proof-
of-concept study, we showed the potential of back-
210 In this
proof-
of-concept study, we sought to evaluate the variat
211 In a
proof-
of-concept study, we supplemented PA to therapy-na
212 In the current
proof-
of-concept study, we tested whether virus reactiva
213 In this
proof-
of-concept study, we used high-resolution mass spe
214 Therefore, this
proof-
of-concept technique shows significant potential f
215 fied with high recoveries under a battery of
proof-
of-concept testing scenarios in various matrices.
216 Thus, this preclinical study provides
proof-
of-concept that combining antiparasite MIF-blockin
217 The present study provides the first
proof-
of-concept that fat-specific cold mimetics via act
218 This work is not only a
proof-
of-concept that HDX-MS can be used to get structur
219 anded CMV-specific CD8+ T cells has provided
proof-
of-concept that immunotherapy can be highly effect
220 Our study provides a
proof-
of-concept that it is possible to discriminate ant
221 These results provide
proof-
of-concept that MHC-E-restricted CD8(+) T cells co
222 We also provide
proof-
of-concept that polarized HLCs can be used for pha
223 This study provides the first
proof-
of-concept that stable, hydrophobic oxidovanadium
224 This study provides a
proof-
of-concept that the plant-soil feedback concept ca
225 A
proof-
of-concept therapy study with a single administrat
226 The new metric was used as a
proof-
of-concept to assess transplant-program access com
227 vertible mEos expressed as intrabodies, as a
proof-
of-concept to perform single-particle tracking on
228 We provide a
proof-
of-concept to show how Raman spectroscopy can be u
229 faces of the cholangiocyte channel, allowing
proof-
of-concept toxicity studies with the biliary toxin
230 (ADME) properties, which was progressed into
proof-
of-concept translation of in vitro antiparasitic a
231 2-week, double-blind, randomized, controlled
proof-
of-concept trial of prazosin (16 mg/day, with a 2-
232 As a
proof-
of-concept we analyze the htTPM signal for two DNA
233 rmacokinetics properties and finally in vivo
proof-
of-concept while ensuring selectivity over related
234 A
proof-
of-concept workflow study for the fabrication of c
235 As a
proof-
of-concept, an X-ray phase contrast under bending
236 As a
proof-
of-concept, electrooxidative C-H/N-H coupling and
237 ions and challenges in achieving preclinical
proof-
of-concept, including in vivo mitophagy reporter m
238 As a
proof-
of-concept, it is demonstrated that these material
239 tanding of the processes involved beyond the
proof-
of-concept, particularly for selective methane oxi
240 In this
proof-
of-concept, prospective non-randomized study carri
241 As a
proof-
of-concept, this technique was then applied to hai
242 As a
proof-
of-concept, we analyzed the elemental profiles of
243 As a
proof-
of-concept, we demonstrate a design of a sensor fo
244 As a
proof-
of-concept, we demonstrate how the molecular calor
245 As
proof-
of-concept, we employed net-clipping to form three
246 As a
proof-
of-concept, we first investigate the utility of CO
247 As a
proof-
of-concept, we generated Solanum tuberosum (potato
248 As a
proof-
of-concept, we have synthesized a nanocrystal-base
249 With this
proof-
of-concept, we hypothesize that biofeedback traini
250 As a
proof-
of-concept, we manufactured and characterized the
251 As a
proof-
of-concept, we propose a novel approach for castin
252 For initial
proof-
of-concept, we selected Mef2d, which when overexpr
253 As a
proof-
of-concept, we show that an OCS pipeline focused o
254 As a
proof-
of-concept, we show that joint DA of multiple inde
255 As a
proof-
of-concept, we used this technique to measure the
256 ach toward these heterolayered dendrimers as
proof-
of-concept.
257 enome design, using genome minimisation as a
proof-
of-concept.
258 Taking a
proof-
of-mechanism approach under the auspices of the Na
259 h autism spectrum disorder in an exploratory
proof-
of-mechanism study.
260 Our
proof-
of-principle analyses facilitated informative stra
261 Application of 16S Capture to a
proof-
of-principle case series demonstrated its ability
262 A few reporters have migrated to
proof-
of-principle clinical demonstrations, and recent a
263 omized, sham-controlled trials have provided
proof-
of-principle data for its blood pressure-lowering
264 We also provide
proof-
of-principle data that gene-targeting ASOs can be
265 Our work serves as a
proof-
of-principle demonstration of the capability of ou
266 As a
proof-
of-principle demonstration, we show that this silk
267 itumorigenic action, and provide preclinical
proof-
of-principle evidence for targeting EZH2 in patien
268 m x 1,000 bps) prototype are demonstrated as
proof-
of-principle exemplars for the enhanced method of
269 In a
proof-
of-principle experiment, we demonstrate high-fidel
270 a Cre-dependent calling cards system and, in
proof-
of-principle experiments, show utility in defining
271 tter than 25 mum was obtained in these first
proof-
of-principle experiments.
272 This provides the
proof-
of-principle for a new metabolic modeling framewor
273 This study provides the
proof-
of-principle for a translational CRISPR-based appr
274 cohort studies and the CALERIE trial provide
proof-
of-principle for DunedinPoAm as a single-time-poin
275 Their
proof-
of-principle for generating human tissue is demons
276 dy, we describe an optimized high-throughput
proof-
of-principle method for the expanded generation, e
277 Recent work has demonstrated
proof-
of-principle prototype systems; however, very unev
278 Proof-
of-principle studies showing simultaneous measurem
279 This
proof-
of-principle study demonstrates that features of n
280 This
proof-
of-principle study suggests that it may be feasibl
281 In this
proof-
of-principle study, we have utilized label-free sp
282 ensory neurons as a model system, we provide
proof-
of-principle that aberrant expression of fusogens
283 We also provide
proof-
of-principle that FDA-approved inhibitors with act
284 domized pilot trial, we have established the
proof-
of-principle that transcatheter bariatric emboloth
285 To establish
proof-
of-principle therapeutic effects, we tested PEAMOt
286 In conclusion, we provide
proof-
of-principle to propose AD is a PCBDopathy, a dise
287 We demonstrate here the
proof-
of-principle visual characterization of the reacti
288 As
proof-
of-principle, "NAMB" chemistry was utilized for th
289 Having demonstrated
proof-
of-principle, this method can be applied to identi
290 As a
proof-
of-principle, we apply MutSpace to 560 breast canc
291 As an initial
proof-
of-principle, we chose an anchoring molecule compo
292 As a
proof-
of-principle, we have applied CIT-MS to compare th
293 As a
proof-
of-principle, we report the rapid and efficient fi
294 As
proof-
of-principle, we used site-specific mutagenesis to
295 As
proofs-
of-concept, the rGO-PLA electrode was applied for
296 Many RNA viruses encode a
proof-
reading deficient, low-fidelity RNA-dependent poly
297 f protective mechanisms identified in cancer-
proof species.
298 o as to reflect the versions supplied during
proofs stage.
299 ounting evidence, yet with varying levels of
proof,
suggests that dietary fibers (DFs) may exert a pr
300 , although they do not constitute a rigorous
proof thereof.