1 ed, allowing for the initiation of a Phase-2
proof of concept study.
2 sis in a double-blind sham-controlled design
proof of concept study.
3 percutaneous nephrolithotomy (PCNL) in this
proof-of-concept study.
4 d only 2 hospitals in Tanzania and is thus a
proof-of-concept study.
5 uropeptide FF analogue) were subject of this
proof-of-concept study.
6 e-blind, placebo-controlled human laboratory
proof-of-concept study.
7 halimene-type terpenoids and analogues as a
proof-of-concept study.
8 as a potent and selective tool compound for
proof of concept studies.
9 routine care in non-randomised, exploratory
proof-of-concept studies.
10 mphasis on mechanistic advances and clinical
proof-of-concept studies.
11 tentially limiting their utility for in vivo
proof-of-concept studies.
12 iral therapy (HXTCs) are a powerful tool for
proof-of-concept studies.
13 imize such RF-induced heating in preliminary
proof-of-concept studies.
14 Methods: In this
proof-of-concept study,
11 patients with lymphoma of the
15 ) antifibrotic trial design; (2) preclinical
proof-of-concept studies; (
3) pharmacological targets, i
16 As a
proof-of-concept study,
a model involving degenerative i
17 In this
proof-of-concept study,
a new two-step method for the de
18 In this
proof-of-concept study,
a positive PV-Haufen test was on
19 This
proof-of-concept study aimed to assess the effect of par
20 This is a
proof of concept study aiming to quantify neurovascular
21 In this
proof-of-concept study,
all patients with chronic HCV wi
22 ion limits of 99 nM were established in this
proof-of-concept study (
although significantly lower val
23 In this
proof-of-concept study,
an active-template coupling is u
24 In this
proof-of-concept study,
an antioxidant-inspired drug dis
25 In this
proof-of-concept study,
an extensive structure-activity
26 On the basis of
proof-of-concept studies and an excellent safety profile
27 utic targets is of enormous utility for both
proof-of-concept studies and for the development of pote
28 This oversight potentially confounds
proof-of-concept studies and increases drug development
29 electrode materials, application of scalable
proof-of-concept studies,
and acknowledgment of all trea
30 highlight the portfolio of clinical trials,
proof-of-concept studies,
and mechanistic studies planne
31 As a
proof-of-concept study,
antibodies against the emerging
32 Implications of this
proof of concept study are that fluorescent conjugates o
33 Proof-of-concept studies are being conducted that show t
34 Proof-of-concept studies are needed to determine: 1) the
35 ces in the field of ocular gene therapy, and
proof-of-concept studies are under way to evaluate the s
36 d, double-blind, placebo-controlled, phase 2
proof-of-concept study at 35 centres in the USA.
37 In this
proof-of-concept study azithromycin treatment during RSV
38 As a
proof of concept study,
both the H(2) O(2) and (1) O(2)
39 ) and investigated on clinical isolates as a
proof-of-concept study,
but requiring longer incubation
40 this study was that part 2 was designed as a
proof-of-concept study by contrast with part 1.
41 In this
proof of concept study,
chemical threat agent (CTA) samp
42 ropin (hCG) was used as a model protein in a
proof-of-concept study combining water-soluble dried blo
43 However, a series of relatively small
proof-of-concept studies conducted over the last 15 year
44 This
proof of concept study confirmed that algal-bacterial ph
45 This pilot,
proof-of-concept study consisted of a randomised, double
46 This
proof of concept study could greatly impact the accessib
47 The results in this
proof of concept study demonstrate the potential of this
48 Furthermore,
proof-of-concept studies demonstrate that treatment with
49 This
proof-of-concept study demonstrated detectable TAF/FTC v
50 In summary, the
proof-of-concept study demonstrated that next-generation
51 This
proof of concept study demonstrates reversible electroch
52 This
proof of concept study demonstrates that bacterial flora
53 Our
proof of concept study demonstrates that MALDI MSI could
54 This
proof of concept study demonstrates that mD-LC/MS has th
55 This
proof of concept study demonstrates that pericardial res
56 This "
proof of concept" study demonstrates that human exposure
57 This
proof-of-concept study demonstrates a modular approach t
58 This
proof-of-concept study demonstrates that behavioral phar
59 Collectively, this
proof-of-concept study demonstrates that empowering pati
60 This
proof-of-concept study demonstrates that high-frequency
61 This
proof-of-concept study demonstrates that no longer routi
62 Our
proof-of-concept study demonstrates that protein express
63 This
proof-of-concept study demonstrates that the proposed sy
64 This
proof-of-concept study demonstrates that the tissue orig
65 This
proof-of-concept study demonstrates the feasibility of a
66 This
proof-of-concept study demonstrates the possibility of d
67 This
proof-of-concept study demonstrates the potential of MRI
68 This
proof-of-concept study demonstrates the potential of the
69 This
proof-of-concept study demonstrates the quantitative ima
70 This
proof-of-concept study demonstrates the value of Raman s
71 This work represents a novel
proof-of-concept study demonstrating the feasibility of
72 This work represents a
proof-of-concept study demonstrating the utility of enzy
73 In a
proof-of-concept study,
Der p 1 and OVA levels were dete
74 This
proof-of-concept study describes the encapsulation of fa
75 We present a
proof of concept study designed to support the clinical
76 Cure experiments are
proof-of-concept studies designed to evaluate novel para
77 In the human
proof-of-concept study,
DSR solution was well tolerated
78 These preclinical
proof-of-concept studies establish the feasibility of ge
79 This multicenter, open-label,
proof-of-concept study evaluated the anti-IL12/23 monocl
80 This first-in-human
proof-of-concept study evaluated the clinical and biolog
81 C compared with liver tissue, we conducted a
proof-of-concept study evaluating the efficacy of 3'-deo
82 This
proof-of-concept study examined the effect of laryngeal
83 This
proof of concept study explored using a novel digital-me
84 These findings validate a
proof of concept study exposure of extant tumor lines to
85 This
proof-of-concept study focused on hip fractures, but use
86 In this pilot,
proof-of-concept study,
focused investigation of stillbi
87 tudy provides a potential platform for early
proof of concept studies for NTHi vaccines, as well as a
88 hy human subjects prior to the initiation of
proof of concept studies for the treatment of mood disor
89 These data represent a
proof of concept study for basic decoding of speech imag
90 We present a
proof of concept study for electrochemical detection of
91 trical properties and can be considered as a
proof of concept study for the detection of various anal
92 This
proof-of-concept study found that machine learning and e
93 uited for this an open-label, single-centre,
proof-of-concept study from Nov 1, 2017, to Nov 30, 2018
94 This
proof-of-concept study has demonstrated that hyperpolari
95 A
proof-of-concept study has demonstrated the application
96 discovery of gammadelta T cells >30 y ago, a
proof-of-concept study has not been done to prove the pr
97 Overall, this
proof-of-concept study has supported the development of
98 ts that potentially influence the host, many
proof-of-concept studies have demonstrated causative rol
99 Recently,
proof-of-concept studies have demonstrated genotype-phen
100 Indeed, preclinical
proof-of-concept studies have demonstrated that both G p
101 Various
proof-of-concept studies have shown the potential of bio
102 These
proof-of-concept studies highlight the potential to boos
103 This
proof-of-concept study highlights the mechanisms underly
104 This
proof-of-concept study holds promise as a novel immunoth
105 Overall, this
proof-of-concept study illustrates an efficient, general
106 Thus, these compounds are useful for
proof of concept studies in a variety of models where EP
107 bility, thus making it an effective tool for
proof-of-concept studies in a clinical setting.
108 es face daunting challenges in the design of
proof-of-concept studies in animal models.
109 of ATM inhibitor molecules to enable in vivo
proof-of-concept studies in HD animal models.
110 er preclinical evaluation as a candidate for
proof-of-concept studies in humans.
111 ency, solubility, and lipophilicity to allow
proof-of-concept studies in mice.
112 ogenesis, support wide-ranging benefits from
proof-of-concept studies in MIDD.
113 on (ADME) profiles were subjected to in vivo
proof-of-concept studies in NMRI mice harboring the rode
114 may be a useful clinical trial end point for
proof-of-concept studies in patients with DR.
115 esting a practical translational pathway for
proof-of-concept studies in people with spinal cord inju
116 Based on
proof-of-concept studies in the Plasmodium yoelii murine
117 After
proof-of-concept studies in which a mixture of five mode
118 ed, three-way, incomplete block, cross-over,
proof-of-concept study in 71 patients with AR, evaluated
119 In a
proof-of-concept study in a muscle-specific ring finger
120 Preclinical evidence and data from a
proof-of-concept study in healthy volunteers suggest tha
121 A
proof-of-concept study in mouse demonstrates the potenti
122 Preclinical studies as well as a
proof-of-concept study in type 1 diabetic patients and h
123 IMPAACT P1115 is a multinational phase 1/2
proof-of-concept study in which presumptive treatment fo
124 t this hypothesis clinically, we developed a
proof-of-concept study,
in which patients with EGFR-muta
125 This single-center retrospective
proof-of-concept study included 32 patients with documen
126 Other GSDs have been treated in
proof-of-concept studies,
including GSD III, IV and V.
127 These
proof-of-concept studies indicate that alphaDR5-NPs load
128 Additionally, a preliminary
proof-of-concept study indicated an amide I band shift b
129 Conclusion This
proof-of-concept study indicates that TA of nonenhanced
130 Some of these compounds have now moved from
proof-of-concept studies into clinical trials, with pros
131 The second
proof-of-concept study involved the fabrication of a 96-
132 This
proof-of-concept study involves plasmonic characterizati
133 A
proof of concept study involving the online coupling of
134 Surprisingly, techniques used in
proof-of-concept studies involving abnormally fertilized
135 andomized, double-blind, placebo-controlled,
proof-of-concept study involving 111 infants less than 1
136 A "
proof of concept" study is reported, which demonstrates
137 The first
proof-of-concept study is carried out with 5- and 7-chan
138 A
proof-of-concept study is conducted on the detection of
139 uencing to predict rejection events, as this
proof-of-concept study is limited to a small number of p
140 A
proof-of-concept study is presented on the use of compre
141 This initial
proof-of-concept study is the first application of DREAD
142 This
proof-of-concept study is the first in which the culture
143 The present
proof-of-concept study is the first, to our knowledge, t
144 In this
proof-of-concept study,
it appears feasible to perform a
145 Collectively, this
proof-of-concept study links urine peptidomics to molecu
146 Here, we used, in a
proof-of-concept study,
matrix-assisted laser desorption
147 of the peripheral nervous system in MS, this
proof-of-concept study may offer new insights into the p
148 Proof of concept studies of tissue phantoms yielded a me
149 In this
proof of concept study of an oxygenated and perfused bio
150 This work presents a
proof of concept study of this idea.
151 of this study was to perform a preclinical "
proof of concept" study of Bergamot polyphenolic formula
152 In our recent article, we elaborate our
proof-of-concept studies of a mouse/human chimeric IgE a
153 , and perform extensive characterization and
proof-of-concept studies of mSncg promoter-mediated gene
154 get engagement and assist dose selection for
proof-of-concept studies of PAM compounds.
155 en employed in the literature as a model for
proof-of-concept studies of perspective biosensing appli
156 homologs in the mouse has precluded in vivo
proof-of-concept studies of specific therapies targeting
157 veral widely used datasets and apply it to a
proof-of-concept study of orthologous proteomes in an in
158 Hence, each model can be evaluated in "
proof-of-concept" studies of preconception vaccination a
159 In this
proof-of-concept study,
oligomeric peptides are biologic
160 Here, by presenting a series of
proof-of-concept studies on electrically triggered funct
161 Proof-of-concept studies on human cancers and cardiovasc
162 Therefore, we present a
proof-of-concept study on an analytical experimental tes
163 epare and to subsequently perform a clinical
proof-of-concept study on the general suitability of sil
164 As a
proof-of-concept study,
our microfluidic device was coup
165 ) initial short-term readouts in early phase/
proof-of-concept studies over 6 or 9 months, and (2) sec
166 In these open-label
proof-of-concept studies,
patients with ALS were enrolle
167 This
proof of concept study paves the route toward a potentia
168 Conclusion In this
proof-of-concept study,
percentage of T1 shortening at e
169 The
proof-of-concept study (
POC) was an 8-week, double-blind
170 This
proof-of-concept study presents Raman hyperspectroscopic
171 In this
proof of concept study,
pretreatment with simvastatin in
172 This
proof of concept study provides an approach for the rati
173 This
proof-of-concept study provides a basis for developing a
174 This
proof-of-concept study provides a basis for developing a
175 Collectively, this
proof-of-concept study provides a first example of photo
176 This
proof-of-concept study provides a new direction for regu
177 This
proof-of-concept study provides a new methodology for NI
178 This
proof-of-concept study provides a platform that could be
179 Our
proof-of-concept study provides a powerful new methodolo
180 This
proof-of-concept study provides a simple yet robust appr
181 This
proof-of-concept study provides clues that hepatic USPIO
182 Our
proof-of-concept study provides computational evidence f
183 In conclusion, our
proof-of-concept study provides strong evidence that usi
184 Our
proof-of-concept study provides time-resolved insight in
185 In this
proof-of-concept study,
Raman microscopy was used to dif
186 In this
proof-of-concept study,
Raman microspectroscopy was util
187 In a
proof-of-concept study,
rapid screening of ten samples w
188 Our
proof-of concept study results demonstrate CMLD-2 repres
189 Findings: Multiple
proof-of-concept studies reveal the feasibility and effi
190 In this
proof-of-concept study,
rituximab, which is a reference
191 This
proof-of-concept study sheds light on genotype-phenotype
192 cosa, and therefore, the outcome measures in
proof-of-concept studies should be based on evaluation o
193 Data from our
proof-of-concept study show that SL RNA detection has hi
194 This
proof of concept study showed that formulation in nanopa
195 This
proof-of-concept study showed that AAV-mediated delivery
196 The
proof-of-concept study showed that BBD treatment of MTB-
197 This is a first
proof of concept study showing that modulating the catab
198 This
proof of concept study shows that the re-establishment o
199 This
proof-of-concept study shows how integration of microfab
200 This
proof-of-concept study shows that the biosensor could de
201 This
proof-of-concept study shows that the development of bot
202 In this
proof-of-concept study,
stable isotope probing (SIP) was
203 Taken together, the data from this
proof-of-concept study strongly suggest that M3R PAMs ma
204 Results of this
proof-of-concept study suggest that a larger trial, powe
205 Our
proof of concept study suggests that scaffolds loaded wi
206 This
proof-of-concept study suggests a new multivariable anal
207 This
proof-of-concept study suggests that activation of ocula
208 This successful
proof-of-concept study suggests that drugs targeting NS4
209 This
proof-of-concept study suggests that TNF antagonism does
210 Our
proof-of-concept study suggests that, with development,
211 These
proof-of-concept studies support the further optimizatio
212 These
proof-of-concept studies support the use of IONPs to enh
213 This positive
proof-of-concept study supports the continued developmen
214 This
proof of concept study targets the translational rigor o
215 ecificity, 72% [29 of 40]).ConclusionIn this
proof-of-concept study,
texture analysis applied on card
216 adrenergic receptor as a model, we present a
proof of concept study that assessed the bias of 19 beta
217 We demonstrate in a
proof-of-concept study that Ce6-PVP-based fluorescence e
218 We describe a
proof-of-concept study that uses a model system consisti
219 Here we show, in this
proof-of-concept study,
that [1-(13)C] alpha-ketoglutara
220 In this
proof of concept study,
the sensor was utilized to inves
221 In a
proof-of-concept study,
the 3D CMs have been further exp
222 In a
proof-of-concept study,
the decellularized grafts are im
223 In a preclinical
proof-of-concept study,
the ex vivo and in vivo [(11)C]5
224 In this
proof-of-concept study,
the feasibility of this techniqu
225 In this
proof-of-concept study,
the use of a covalent binding pe
226 In
proof-of-concept studies,
this cp-Fab/CAR-T system targe
227 In a
proof-of-concept study,
through only external calibratio
228 pursued by the research community for these
proof-of-concept studies to achieve the goal of accelera
229 We did a nested, case-control,
proof-of-concept study to compare the prevalence of CHIP
230 This is the first
proof-of-concept study to demonstrate successful read-th
231 This paper is the first
proof-of-concept study to demonstrate that GHz ultrasoun
232 Here, we present a
proof-of-concept study to determine the feasibility of u
233 erformed a double-blind, placebo-controlled,
proof-of-concept study to evaluate the effects of OCA on
234 Here, we present a
proof-of-concept study to examine the microbial link bet
235 Here we report a
proof-of-concept study to integrate genomic prediction i
236 Here, we present a
proof-of-concept study to noninvasively derive the therm
237 ctrometry has been demonstrated, via various
proof-of-concept studies,
to offer a powerful, rather un
238 For
proof-of-concept studies,
two crucial redox enzymes for
239 In this small
proof-of-concept study,
two different three-drug regimen
240 tutional review board-approved, prospective,
proof-of-concept study,
unaffected and affected gut segm
241 Here, we present a
proof of concept study using an in silico/in vitro targe
242 ure (IdeS digestion x reduction-HILIC/MS), a
proof of concept study using two mAbs is described here.
243 The role of SOCS1 was inferred by
proof-of-concept studies using overexpression with repor
244 An in vivo
proof-of-concept study using a DOTA-folate conjugate dem
245 Finally, we performed a
proof-of-concept study using our work flow and CyteFinde
246 In this
proof-of-concept study,
using stem cells derived from sk
247 The phase 2a,
proof-of-concept study was an open-label, adaptive dose-
248 A human clinical
proof-of-concept study was completed in eight FA patient
249 This
proof-of-concept study was conducted to determine whethe
250 A
proof-of-concept study was conducted using T2 bacterioph
251 This
proof-of-concept study was designed to determine if func
252 sed on a meta-Lasso regression model and the
proof-of-concept study was performed using a large-scale
253 Proof-of-concept study was performed with caper bud extr
254 The aim of this
proof-of-concept study was to evaluate a novel CXCR4-tar
255 Taken together, by using
proof-of-concept studies we demonstrate for the first ti
256 In
proof-of-concept studies we validated 16 high-confidence
257 Here, in a first
proof-of-concept study we tested whether SD induces a de
258 In the current
proof-of-concept study we utilized TERS to identify indi
259 As a model (an example or
proof-of-concept study)
we have used a functional calciu
260 In this
proof of concept study,
we combine the advantages of an
261 In this
proof of concept study,
we demonstrate the feasibility o
262 In a
proof of concept study,
we subsequently developed a phot
263 As a
proof-of concept study,
we used MiMoSA to model the grow
264 In
proof-of-concept studies,
we further documented differen
265 In a
proof-of-concept study,
we aimed to assess the effect on
266 In this
proof-of-concept study,
we compare broadband and narrowb
267 In a
proof-of-concept study,
we defined two groups (1) an acu
268 erein, taking beta-Ni(OH)2 nanosheets as the
proof-of-concept study,
we demonstrated a surface-chemis
269 In this
proof-of-concept study,
we demonstrated that (89)Zr-tras
270 In a
proof-of-concept study,
we enrolled 10 patients with lun
271 In a
proof-of-concept study,
we established CTC cultures from
272 In our
proof-of-concept study,
we evaluated the capability of t
273 In this
proof-of-concept study,
we focused on the novel use of e
274 In our
proof-of-concept study,
we furthermore demonstrate, on e
275 As a
proof-of-concept study,
we have applied matrix-assisted
276 In this
proof-of-concept study,
we implemented a molecular-barco
277 In this
proof-of-concept study,
we included people living with H
278 In this
proof-of-concept study,
we investigated the feasibility
279 In a
proof-of-concept study,
we previously showed that colore
280 Based on this first
proof-of-concept study,
we propose multi-scale phase con
281 In our
proof-of-concept study,
we resolve the silicon lattice d
282 In a
proof-of-concept study,
we show that a novel vaccine app
283 Conclusion: In this
proof-of-concept study,
we showed the potential of back-
284 In this
proof-of-concept study,
we sought to evaluate the variat
285 In a
proof-of-concept study,
we supplemented PA to therapy-na
286 uantification of NF-L in blood, and ii) in a
proof-of-concept study,
we tested our newly developed me
287 In the current
proof-of-concept study,
we tested whether virus reactiva
288 In this
proof-of-concept study,
we used high-resolution mass spe
289 Proof of concept studies were performed to detect saliva
290 antibody, exhibited promising activity in a
proof-of-concept study when administered in intravenous
291 For the first time, we report a
proof of concept study where autologous blood outgrowth
292 hortened half-life in vivo Here we present a
proof of concept study where we identify sites to incorp
293 The aim of this study was a
proof of concept study whether these same data sets can
294 This
proof-of-concept study,
which employs a chiral pool suga
295 as considered indicative of a trend for this
proof of concept study,
while statistical significance w
296 Proof-of-concept studies with CD3xHER2 BsAb (T-cell recr
297 Proof-of-concept studies with HER2xCD3 (T-cell recruitme
298 reath sampling and analysis are challenging,
proof-of-concept studies with mass spectrometry and elec
299 The first
proof-of-concept studies with the clinically relevant ca
300 Proof-of-concept studies with the newly developed analyt