ライフサイエンスコーパス: proopiomelanocortin

1 ng hormone but not in the cells that express proopiomelanocortin.

2 e of processing of the endogenous prohormone proopiomelanocortin.

3 transmembrane domain, was similar to that of proopiomelanocortin.

4 nitoring 18-kDa fragment-NH2 production from proopiomelanocortin.

5 AgRP and up-regulation of the expression of proopiomelanocortin/alpha-melanocyte-stimulating hormone

6 diminished synthesis and levels of pituitary proopiomelanocortin/alpha-MSH, associated with decreased

7 The corticotropin precursor proopiomelanocortin and corticotropin expression were as

8 ous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous imm

9 ecreased in the Dicer1 mutant mouse, whereas proopiomelanocortin and luteinizing hormone beta-subunit

10 signaling as a common cellular mechanism in proopiomelanocortin and neuropeptide Y/agouti-related pr

11 tion: increased neuropeptide Y and decreased proopiomelanocortin and neurotensin mRNAs in the arcuate

12 ling-3 (SOCS3) occurs in AgRP neurons before proopiomelanocortin and other hypothalamic neurons.

13 le to slow convertase-mediated processing of proopiomelanocortin and proenkephalin; however, similarl

14 Surprisingly, when proopiomelanocortin and proglucagon were co-expressed in

15 s, while the levels of peptides derived from proopiomelanocortin and provasopressin did not show subs

16 refore having an impact on the processing of proopiomelanocortin and thus on energy homeostasis.

17 phalin, in vivo production of alpha-MSH from proopiomelanocortin, and in vitro cleavage of a PC2-spec

18 uropeptides, notably agouti-related peptide, proopiomelanocortin, and neuropeptide Y.

19 pothalamic melanin-concentrating hormone and proopiomelanocortin but not hypocretin/orexin neurons; p

20 ed by PUFAs resulted in increased numbers of proopiomelanocortin but not NPY neurons and was accompan

21 precursors, proenkephalin, prodynorphin, and proopiomelanocortin, by sequential proteolytic processin

22 the arcuate nucleus, both Neuropeptide Y and proopiomelanocortin cells expressed tdTomato.

23 our studies on the cutaneous expression of a proopiomelanocortin/corticotropin-releasing hormone syst

24 itiated, open-label study, two patients with proopiomelanocortin deficiency were treated with setmela

25 is of peptide hormones, such as glucagon and proopiomelanocortin-derived alpha-melanocyte-stimulating

26 nts the major influence on intermediate lobe proopiomelanocortin-derived peptide secretion, dopamine

27 ing hormone (CRH); arginine vasopressin; the proopiomelanocortin-derived peptides alpha-melanocyte-st

28 ocortisolism, resulting from the lack of the proopiomelanocortin-derived peptides melanocyte-stimulat

29 Using proopiomelanocortin enhanced-green fluorescent protein r

30 teractions of several opioid peptides [e.g., proopiomelanocortin, enkephalin (ENK)] with the stress-r

31 ally in the arcuate nucleus is inhibitory on proopiomelanocortin-expressing (POMC) neurons.

32 Using proopiomelanocortin-expressing cells located in the arcu

33 t arose from non-KNDy ARC neurons, including proopiomelanocortin-expressing cells.

34 ells with no concomitant effect on pituitary proopiomelanocortin-expressing corticotrophs in the mous

35 Proopiomelanocortin-expressing intermediate lobe pituita

36 in which insulin expression was targeted to proopiomelanocortin-expressing pituitary cells.

37 ed with increased expression of hypothalamic proopiomelanocortin following leptin stimulation.

38 Null mutations of the proopiomelanocortin gene (Pomc) cause obesity in humans

39 egulation depend on proper expression of the proopiomelanocortin gene (Pomc) in a group of neurons lo

40 y selectively blocking the expression of the proopiomelanocortin gene (Pomc) in hypothalamic neurons.

41 This chromosomal region contains the proopiomelanocortin gene (POMC).

42 of leukemia inhibitory factor (LIF)-mediated proopiomelanocortin gene expression and adrenocorticotro

43 Additionally, apoE-stimulated hypothalamic proopiomelanocortin gene expression and SHU9119, a melan

44 investigated by targeted mutagenesis of the proopiomelanocortin gene in mouse embryonic stem cells.

45 f five reported receptors, agonists from the proopiomelanocortin gene transcript, and two antagonists

46 The tyrosine codon at position 179 of the proopiomelanocortin gene was converted to a premature tr

47 es is 2-3-fold lower than that of endogenous proopiomelanocortin in AtT-20 cells or prolactin in GH3

48 othalamic neurons express neuropeptide Y and proopiomelanocortin in the arcuate nucleus, melanin-conc

49 n of neuropeptide Y and higher expression of proopiomelanocortin in the hypothalamus.

50 the genes encoding the hormones insulin and proopiomelanocortin is potentiated by lineage-specific h

51 ciated with decreased levels of hypothalamic proopiomelanocortin, leading to increased food intake an

52 romogranin A, and on peptides processed from proopiomelanocortin, manifest similar striking sensitivi

53 to detect altered CNS expression levels for proopiomelanocortin, Mc3r, Mc4r, or NPY mRNAs in Agrp(-/

54 NA by stimulating the central nervous system proopiomelanocortin-melanocortin 4 receptor pathway, and

55 The expression of proopiomelanocortin messenger RNA (mRNA) was detected in

56 Three different precursors, mouse proopiomelanocortin (mPOMC), rat proenkephalin (rPE), an

57 ation in plasma corticosterone and pituitary proopiomelanocortin mRNA expression, although the increa

58 Inflammation increased proopiomelanocortin mRNA in cells from noninflamed and i

59 Proopiomelanocortin mRNA was enhanced after 6h with the

60 In normal animals, END and proopiomelanocortin mRNA were less abundant in circulati

61 e were significant decreases in GK, NPY, and proopiomelanocortin mRNA.

62 omplex and reactive super-oxygen species for proopiomelanocortin neuronal killing.

63 ricular nucleus (GLP-1RKD(DeltaSim1cre)) and proopiomelanocortin neurons (GLP-1RKD(DeltaPOMCcre)).

64 lus leptin into the CNS or the activation of proopiomelanocortin neurons also increased WAT browning

65 PTP enhanced insulin and leptin signaling in proopiomelanocortin neurons and prevented diet-induced o

66 ition from the AgRP neurons onto neighboring proopiomelanocortin neurons and their common postsynapti

67 alyses in vivo, we found that astrocytes and proopiomelanocortin neurons are responsible for the prod

68 communication with islets, and activation of proopiomelanocortin neurons by leptin enhances insulin s

69 ed protein (AgRP)-expressing neurons precede proopiomelanocortin neurons in developing diet-induced c

70 from both agouti-related peptide (AgRP) and proopiomelanocortin neurons in the arcuate nucleus (Arc)

71 hetic nerve activity (SNA) via activation of proopiomelanocortin neurons in the arcuate nucleus (ArcN

72 ion of the loss of CEACAM1 from anorexigenic proopiomelanocortin neurons in the arcuate nucleus is un

73 amus and colocalizes with neuropeptide Y and proopiomelanocortin neurons in the arcuate nucleus.

74 odulating the activity of neuropeptide Y and proopiomelanocortin neurons in the hypothalamic arcuate

75 Proopiomelanocortin neurons known to regulate stress, en

76 tration of PK2 increased c-fos expression in proopiomelanocortin neurons of the arcuate nucleus (ARC)

77 y the specific nuclei and cell type, such as proopiomelanocortin neurons of the arcuate nucleus, that

78 induction of cilia loss in leptin-responsive proopiomelanocortin neurons results in obesity, implicat

79 Hypothalamic proopiomelanocortin neurons selectively innervate the an

80 ions that excite other ARC neurons including proopiomelanocortin neurons that can play an important r

81 that depolarization of appetite-suppressing proopiomelanocortin neurons was impaired in knock-in mic

82 n feeding, coexpression with arcuate nucleus proopiomelanocortin neurons, and on limited analysis of

83 sed in the vast majority of leptin-sensitive proopiomelanocortin neurons, highlighting their importan

84 receive input from leptin-responsive arcuate proopiomelanocortin neurons, the physiological functions

85 ough monocarboxylate transporters to arcuate proopiomelanocortin neurons, which integrate this signal

86 on on arcuate NPY/agouti-related protein and proopiomelanocortin neurons.

87 excitatory synaptic activity in anorexigenic proopiomelanocortin neurons.

88 nt role in maintaining leptin sensitivity in proopiomelanocortin neurons.

89 ceptors in guinea pig and mouse hypothalamic proopiomelanocortin neurons.

90 ostsynaptic currents onto neuropeptide Y and proopiomelanocortin neurons.

91 te-regulating neurons in the arcuate, namely proopiomelanocortin neurons.

92 on neuropeptide Y/agouti-related protein and proopiomelanocortin neurons.

93 ergy regulatory circuit by stimulating POMC (proopiomelanocortin) neurons of the MBH, oxytocin neuron

94 orexigenic (NPY and AgRP) and anorexigenic (proopiomelanocortin) neuropeptide mRNAs.

95 olically relevant hypothalamic neuropeptides proopiomelanocortin, neuropeptide Y, and agouti-related

96 fects of highly restricted neuronal subsets (proopiomelanocortin, neuropeptide Y/agouti-related pepti

97 retinal ganglion cells and requires the CRF-proopiomelanocortin pathway to exert its effect on camou

98 translation were carried out to produce the proopiomelanocortin peptide.

99 in the arcuate nucleus (N/OFQ(ARC) ) inhibit proopiomelanocortin (POMC(ARC) ) neurones in a diet- and

100 ransmitters, hypothalamic neurons, including proopiomelanocortin (POMC) and agouti-related peptide (A

101 ransmitters, hypothalamic neurons, including proopiomelanocortin (POMC) and agouti-related peptide (A

102 aracterized, selective groups neurons [e.g., proopiomelanocortin (POMC) and agouti-related peptide (A

103 or neuropeptides including those expressing proopiomelanocortin (POMC) and agouti-related peptides (

104 using monosynaptic rabies virus showed that proopiomelanocortin (POMC) and agouti-related protein (A

105 es expression of anorexigenic neuropeptides [proopiomelanocortin (POMC) and cocaine- and amphetamine-

106 utide was internalized in neurons expressing proopiomelanocortin (POMC) and cocaine- and amphetamine-

107 In the anterior pituitary, levels of both proopiomelanocortin (POMC) and CRH-receptor 1 (R1) mRNAs

108 es in mice, we characterized the ontogeny of proopiomelanocortin (POMC) and neuropeptide Y (NPY) cell

109 Proopiomelanocortin (POMC) and neuropeptide-Y types of n

110 and neuropeptide expression of anorexigenic proopiomelanocortin (POMC) and orexigenic agouti-related

111 gate changes in the key metabolic regulators proopiomelanocortin (POMC) and the glucocorticoid recept

112 -melanocyte-stimulating hormone derived from proopiomelanocortin (POMC) at the melanocortin 3 recepto

113 Proopiomelanocortin (POMC) can be processed to ACTH and

114 Mouse proopiomelanocortin (POMC) cDNA was cloned into a vector

115 y state.SIGNIFICANCE STATEMENT Activation of proopiomelanocortin (POMC) cells signals satiety, wherea

116 tin innervation of hypothalamic anorexigenic proopiomelanocortin (POMC) cells, coupled with a robust

117 he firing rate of a subpopulation of arcuate proopiomelanocortin (POMC) cells.

118 ve boutons terminate on or near anorexigenic proopiomelanocortin (POMC) cells.

119 ne prolactin (Prl), growth hormone (Gh), and proopiomelanocortin (Pomc) encoding genes are almost exc

120 ific deletion of Pcdh-gammas in anorexigenic proopiomelanocortin (POMC) expressing neurons also leads

121 n a subset of hypothalamic neurons including proopiomelanocortin (POMC) expressing neurons of the Arc

122 ic actions partly by increasing hypothalamic proopiomelanocortin (POMC) expression.

123 y stimulating in vitro and in vivo pituitary proopiomelanocortin (POMC) gene expression and ACTH secr

124 e action of central insulin in regulation of proopiomelanocortin (Pomc) gene expression and food inta

125 shown to reduce food intake and to increase proopiomelanocortin (POMC) gene expression in the hypoth

126 Hypothalamic proopiomelanocortin (POMC) gene expression is reduced in

127 ian stress response by stimulating pituitary proopiomelanocortin (POMC) gene expression, and thus adr

128 eptors, endogenous agonists derived from the proopiomelanocortin (POMC) gene transcript, the endogeno

129 hypothalamic arcuate neurons expressing the proopiomelanocortin (POMC) gene.

130 e gyrus under the transcriptional control of proopiomelanocortin (POMC) genomic sequences.

131 The prohormone precursor proopiomelanocortin (POMC) gives rise to beta-endorphin,

132 ients with rare defects in the gene encoding proopiomelanocortin (POMC) have extreme early-onset obes

133 Agouti-related protein (AGRP) and proopiomelanocortin (POMC) have opposing effects on mela

134 asing factor (CRF), neuropeptide Y (NPY) and proopiomelanocortin (POMC) in hypothalamic neurons on da

135 tromedial nucleus (VMH) and colocalized with proopiomelanocortin (POMC) in the arcuate nucleus (ARC).

136 Proopiomelanocortin (POMC) is a precursor polypeptide fo

137 -targeted expression analyses confirmed that proopiomelanocortin (pomc) is a primary genomic target f

138 Hypothalamic proopiomelanocortin (POMC) is essential for the physiolo

139 It is generally believed that proopiomelanocortin (POMC) is expressed exclusively by n

140 Proopiomelanocortin (POMC) is the precursor for adrenoco

141 TG/securin) targeted to the adenohypophyseal proopiomelanocortin (POMC) lineage, which recapitulated

142 orticotropin-releasing hormone (CRH) induced proopiomelanocortin (POMC) mRNA and ACTH secretion in At

143 /ob mice also exhibit decreased hypothalamic proopiomelanocortin (POMC) mRNA and increased hypothalam

144 orticotroph cell differentiation and induces proopiomelanocortin (POMC) mRNA expression and adrenocor

145 n contrast, the number of neurons expressing proopiomelanocortin (POMC) mRNA in the infundibular nucl

146 increased in the Arc during fasting, whereas proopiomelanocortin (POMC) mRNA levels decreased.

147 ARC proOpiomelanocortin (POMC) mRNA levels were significantl

148 u hybridization for neuropeptide Y (NPY) and proopiomelanocortin (POMC) mRNA was performed in section

149 lucocorticoid insufficiency, basal pituitary proopiomelanocortin (POMC) mRNA, adrenocorticotrophic ho

150 There was no difference in proopiomelanocortin (POMC) mRNA, but NPY mRNA was reduce

151 RCA and Arc of the hypothalamus also contain proopiomelanocortin (POMC) mRNA.

152 e Arc contained neuropeptide Y (NPY) mRNA or proopiomelanocortin (POMC) mRNA.

153 ine vasopressin (AVP) and anterior pituitary proopiomelanocortin (POMC) mRNAs and greater PVN glucoco

154 Increased arcuate proopiomelanocortin (POMC) neuron activity improves gluc

155 ated neuronal death of the stress regulatory proopiomelanocortin (POMC) neuron-producing beta-endorph

156 Here, we have shown that proopiomelanocortin (POMC) neuron-specific deficiency in

157 Arcuate proopiomelanocortin (POMC) neuron-specific deletion of P

158 MCH reduces proopiomelanocortin (POMC) neuronal activity, and the SI

159 in the estrogen-mediated changes of arcuate proopiomelanocortin (POMC) neuronal excitability by usin

160 e, i.e. fasting, N/OFQ inhibits anorexigenic proopiomelanocortin (POMC) neurones to a greater degree

161 eleases glutamate to excite the anorexigenic proopiomelanocortin (POMC) neurons and inhibit the orexi

162 -astrocytes were observed in apposition with proopiomelanocortin (POMC) neurons and ODN selectively a

163 ol of energy homeostasis by the anorexigenic proopiomelanocortin (POMC) neurons and orexigenic agouti

164 In the hypothalamic arcuate nucleus (ARC), proopiomelanocortin (POMC) neurons and the POMC-derived

165 Hypothalamic proopiomelanocortin (POMC) neurons and their peptide pro

166 ntake and energy homeostasis clearly involve proopiomelanocortin (POMC) neurons and their peptide tra

167 Proopiomelanocortin (POMC) neurons are good candidates f

168 Hypothalamic proopiomelanocortin (POMC) neurons are important regulat

169 cused on MOR desensitization in hypothalamic proopiomelanocortin (POMC) neurons as these neurons prod

170 we investigated whether hemorrhage activates proopiomelanocortin (POMC) neurons by measuring Fos immu

171 at selective ablation of PPARgamma in murine proopiomelanocortin (POMC) neurons decreases peroxisome

172 e deletion of the aPKC isoform Pkc-lambda in proopiomelanocortin (POMC) neurons disrupts leptin actio

173 Proopiomelanocortin (POMC) neurons have been intensively

174 Hypothalamic proopiomelanocortin (POMC) neurons have traditionally be

175 tin modulates the median eminence-projecting proopiomelanocortin (POMC) neurons identified by selecti

176 imulated electrical activity of hypothalamic proopiomelanocortin (POMC) neurons in mice were altered

177 Here, whole-cell recordings were made from proopiomelanocortin (POMC) neurons in mouse brain slices

178 (LH) together with neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons in the arcuate nucleu

179 Proopiomelanocortin (POMC) neurons in the arcuate nucleu

180 Proopiomelanocortin (POMC) neurons in the arcuate nucleu

181 gate the patterns of spontaneous activity of proopiomelanocortin (POMC) neurons in the arcuate nucleu

182 the brain reduced food intake and activated proopiomelanocortin (POMC) neurons in the arcuate nucleu

183 )R), a G-protein-coupled receptor, activates proopiomelanocortin (POMC) neurons in the arcuate nucleu

184 Proopiomelanocortin (POMC) neurons in the arcuate nucleu

185 ctivated neuronal death of stress-regulatory proopiomelanocortin (POMC) neurons in the hypothalamus l

186 ppa-opioid receptor (KOR), directly inhibits proopiomelanocortin (POMC) neurons in the hypothalamus t

187 rons potently stimulate food intake, whereas proopiomelanocortin (POMC) neurons inhibit feeding.

188 important role in driving food intake, while proopiomelanocortin (POMC) neurons inhibit feeding.

189 c mu-opioid receptors (MORs) in hypothalamic proopiomelanocortin (POMC) neurons leads to the activati

190 ss InsRs in agouti-related protein (AgRP) or proopiomelanocortin (POMC) neurons of L1 mice.

191 mechanism is the activation of anorexigenic proopiomelanocortin (POMC) neurons of the hypothalamic a

192 Proopiomelanocortin (POMC) neurons of the hypothalamic a

193 igh level in white adipose tissue and in the proopiomelanocortin (POMC) neurons of the hypothalamus.

194 Hypothalamic proopiomelanocortin (POMC) neurons play a critical role

195 Proopiomelanocortin (POMC) neurons play a key role in ma

196 Here, we demonstrate that hypothalamic proopiomelanocortin (POMC) neurons release endocannabino

197 KEY POINTS: Hypothalamic proopiomelanocortin (POMC) neurons release peptide produ

198 Hypothalamic proopiomelanocortin (POMC) neurons release peptide produ

199 Hypothalamic proopiomelanocortin (POMC) neurons release the endogenou

200 ely suppresses the frequency of IPSCs on ARC proopiomelanocortin (POMC) neurons that are mediated by

201 termine whether exposure to N(2)O stimulates proopiomelanocortin (POMC) neurons to release beta-endor

202 t beta-endorphin-producing neurons, that is, proopiomelanocortin (POMC) neurons, are activated during

203 er full restoration of leptin sensitivity to proopiomelanocortin (POMC) neurons, partial correction o

204 ssing effects via activation of hypothalamic proopiomelanocortin (POMC) neurons.

205 the direct action of leptin on hypothalamic proopiomelanocortin (POMC) neurons.

206 lucose is the primary driver of hypothalamic proopiomelanocortin (POMC) neurons.

207 input organization and increased activity of proopiomelanocortin (POMC) neurons.

208 of energy balance depends on the ability of proopiomelanocortin (POMC) or agouti-related protein (Ag

209 ansgenic mice overexpressing Socs3 in either proopiomelanocortin (POMC) or leptin receptor-expressing

210 nic inhibition of arcuate neurons expressing proopiomelanocortin (POMC) or paraventricular hypothalam

211 ed by proteolytic processing of their common proopiomelanocortin (POMC) precursor.

212 tide Y (NPY), Agouti-related protein (AGRP), proopiomelanocortin (POMC) products, and corticotropin-r

213 P-1 shows decreased or increased LIF-induced proopiomelanocortin (POMC) promoter activity, respective

214 lating hormone (MSH) peptides processed from proopiomelanocortin (POMC) regulate energy homeostasis b

215 duced, yet the mRNA of its precursor protein proopiomelanocortin (POMC) remained unaltered.

216 Congenital deficiency of proopiomelanocortin (POMC) results in a syndrome of hypo

217 e lethal yellow (AY/a) mouse has a defect in proopiomelanocortin (POMC) signaling in the brain that l

218 The proopiomelanocortin (POMC) system is the central coordin

219 exposure, epidermal keratinocytes synthesize proopiomelanocortin (POMC) that is processed to melanocy

220 -dependent cytokine family, stimulate murine proopiomelanocortin (POMC) transcription and adrenocorti

221 Expression of melanocortin receptors and proopiomelanocortin (POMC) was analyzed by means of RT-P

222 ric acid (GABA)(+), neuropeptide Y (NPY)(+), proopiomelanocortin (POMC)(+), tyrosine hydroxylase (TH)

223 ticularly focused our study on afferences to proopiomelanocortin (POMC), agouti-related peptide (AgRP

224 oglycemia-induced plasma glucagon, pituitary proopiomelanocortin (POMC), and adrenal c-fos, consisten

225 -10, and TNF-alpha, but not IL-4, IFN-gamma, proopiomelanocortin (POMC), and CD95L (Fas L).

226 transcriptional events in hypothalamic GABA, proopiomelanocortin (POMC), and dopamine neurons.

227 cotropin-releasing hormone (CRH), urocortin, proopiomelanocortin (POMC), and POMC-derived peptides.

228 ofluorescent staining for ACTH, a product of proopiomelanocortin (POMC), and prohormone convertase 1

229 tide Y (NPY), agouti-related protein (AGRP), proopiomelanocortin (POMC), cocaine- and amphetamine-reg

230 ons that express hypothalamic neuron markers proopiomelanocortin (POMC), neuropeptide Y (NPY), agouti

231 vels and fat stores and altered hypothalamic proopiomelanocortin (POMC), neuropeptide Y (NPY), and ag

232 fect arcuate mRNA levels of proEnkephalin or proOpiomelanocortin (POMC), or PVN levels of Met-Enkepha

233 neuropeptides, such as neuropeptide Y (NPY), proopiomelanocortin (POMC), orexin/hypocretin, melanin-c

234 to analyze a number of peptides derived from proopiomelanocortin (POMC), provasopressin, prooxytocin,

235 timulating hormone (alpha-MSH), a product of proopiomelanocortin (POMC), reduce food intake, whereas

236 mors, blocking EGFR suppressed expression of proopiomelanocortin (POMC), the ACTH precursor.

237 Pituitary expression of proopiomelanocortin (POMC), the common precursor for adr

238 Immunolabeling for proopiomelanocortin (POMC), the precursor to beta-endorp

239 ed peptide (Agrp), neuropeptide Y (Npy), and proopiomelanocortin (Pomc), was fully normalized in dual

240 s RIIbeta in agouti-related peptide (AgRP)-, proopiomelanocortin (POMC)-, single-minded 1 (Sim1)-, or

241 The proopiomelanocortin (POMC)-derived neuropeptide alpha-me

242 Neurons containing proopiomelanocortin (POMC)-derived peptides, known to co

243 the capacity for autocrine processing of the proopiomelanocortin (POMC)-derived peptides.

244 neuronal system, including the anorexigenic proopiomelanocortin (POMC)-expressing cells of the arcua

245 For comparison, we also analyzed Proopiomelanocortin (POMC)-expressing neurons, an interm

246 lts in inhibition of downstream anorexigenic proopiomelanocortin (POMC)-positive neurons in a GABA-de

247 Proopiomelanocortin (POMC)-producing cells are present i

248 Proopiomelanocortin (POMC)-producing cells comprise near

249 3R) neuronal activity, including inputs from proopiomelanocortin (POMC)-producing neurons in the arcu

250 Hypothalamic neurons including proopiomelanocortin (POMC)-producing neurons regulate bo

251 produced BEP and its precursor gene product, proopiomelanocortin (POMC).

252 eptide derived from the N-terminal region of proopiomelanocortin (POMC).

253 f the hypothalamic anorexigenic neuropeptide proopiomelanocortin (POMC).

254 R), neuronal growth regulator 1 (NEGR1), and proopiomelanocortin (POMC)] by PUFAs, only 125 genes [e.

255 he strongest eQTM locus was observed for the proopiomelanocortin (POMC; rho = -0.632, P = 4.70 x 10(-

256 related protein; NPY/AgRP) and anorexigenic (proopiomelanocortin; POMC) neurons via an ATP-dependent

257 Despite a severe defect in pituitary proopiomelanocortin processing to mature adrenocorticotr

258 nd kappa, but not delta, opioid receptor and proopiomelanocortin, proenkephalin, and prodynorphin tra

259 des derived from three different precursors: Proopiomelanocortin, proenkephalin, and prodynorphin.

260 tion by endogenous agonists derived from the proopiomelanocortin prohormone: ACTH, alpha-MSH, and gam

261 y pathway proteins, including proenkephalin, proopiomelanocortin, protachykinins A and B, chromograni

262 nd adrenocorticotropic hormone, a product of proopiomelanocortin proteolysis.

263 amic neuropeptide Y RNA levels and increased proopiomelanocortin RNA levels, a set of effects opposit

264 ments of the corticotropin-releasing hormone/proopiomelanocortin system human keratinocytes show high

265 we show that TR4 transcriptionally activates proopiomelanocortin through binding of a direct repeat 1

266 d blunted the effect of insulin or leptin on proopiomelanocortin, thyroid-releasing hormone, melanin-

267 hormone-releasing hormone (GHRH), pituitary proopiomelanocortin to adrenocorticotropic hormone, isle

268 MC1R loss of function decreases melanocytic proopiomelanocortin transcription and systemic melanocyt

269 both human and murine tumor cells increased proopiomelanocortin transcription, ACTH secretion, cellu

270 s lower and expression of the anorexic gene, proopiomelanocortin, was higher.

271 na pellucida glycoprotein 3 (ZP3) and bovine proopiomelanocortin were reported to be LacdiNAc-modifie

272 e had a decreased hypothalamic expression of proopiomelanocortin, which suggests that BBS genes play

273 ohistochemistry showed a marked reduction in proopiomelanocortin with an increase in neuropeptide Y a

274 ulated (amphetamine-regulated transcript and proopiomelanocortin) with fasting were also found to be