ライフサイエンスコーパス: proper function

1 -expressing HSCs but failed to restore their proper function.

2 reprogramming that is necessary to maintain proper function.

3 hannels require the beta subunit barttin for proper function.

4 es that may guide its development and ensure proper function.

5 s must have the right length and pattern for proper function.

6 ncreas, adopt asymmetric positions to ensure proper function.

7 g Snail1 and Snail2, which are essential for proper function.

8 illus subtilis requires the CheD protein for proper function.

9 ing protein turnover, are also essential for proper function.

10 been shown to require SAM polymerization for proper function.

11 rs a DNA-binding motif, for localization and proper function.

12 whose membrane localization is required for proper function.

13 occur in p16-silenced cells, abrogating its proper function.

14 namics, and ion channel expression to ensure proper function.

15 ine phosphorylation of AQP5 are required for proper function.

16 acids within the protein that are needed for proper function.

17 rting of endocytic ligands and receptors for proper function.

18 uire the complete MMOB C-terminal region for proper function.

19 th thought to be important for the peptide's proper function.

20 endrites and may require neddylation for its proper function.

21 ed atypical kinase Mcp2 are required for its proper function.

22 oenvironment, including pericytes, for their proper function.

23 lation of Ca(2+) in neurons is essential for proper function.

24 less the respective mutations preserve their proper function.

25 rmediates undergo quality-control checks for proper function.

26 ans and embryos and is fundamental for their proper function.

27 re to a stimulus which can be imperative for proper function.

28 perties of alpha-catenin are critical to its proper function.

29 an elongation complex that requires RodZ for proper function.

30 rtist's intentions toward an artwork and its proper functions.

31 ss that targets them to specific tissues for proper functions.

32 the nutrients delivery to the brain for its proper functioning.

33 of human cells encodes mechanisms to ensure proper functioning.

34 protein and/or sarcomeric components for its proper functioning.

35 RNase H2C proteins that are all required for proper function and activity.

36 ements of this enzyme that are essential for proper function and also provide supporting evidence tha

37 Guided cell migration is necessary for the proper function and development of many tissues, one of

38 onent of the desmosome, is essential for the proper function and distribution of the gap junction pro

39 important for most biomaterial applications, proper function and integration also requires biomateria

40 evelopment are used post-developmentally for proper function and maintenance of the nervous system.

41 nd require the accessory subunit barttin for proper function and membrane insertion.

42 Cholesterol is essential for proper function and regulation of eukaryotic membranes,

43 Proper function and repair of the digestive system are v

44 r protein therapeutics is required for their proper function and the elimination of deleterious off-t

45 The C-linker/CNBHD is essential for proper function and trafficking of ion channels in the K

46 geometry, are particularly dependent on the proper functioning and distribution of mitochondria.

47 ies demonstrate that AIPL1 is needed for the proper functioning and survival of cone photoreceptors.

48 tiple layers of regulation are essential for proper function, and evolution of this tight control sys

49 : Microcirculatory integrity and proper function are the cornerstones to tissue nourishme

50 de array of mechanisms that facilitate their proper function as modulators and integrators of G-prote

51 he ATPase domain of Vps4 is not required for proper function but plays a role in regulating Vps4 asse

52 ave indicated that each form is required for proper function, but the mechanism of interconversion re

53 The intestinal tract maintains proper function by replacing aged cells with freshly pro

54 aria drives specific T cell dysfunction, and proper function can be restored by inhibitory therapies

55 We also investigated whether proper function could be restored to Treg cells by ex vi

56 -binding ability of an alpha-catenin and its proper function during epithelial morphogenesis.

57 ritical for calcium entry required for their proper function during immune response.

58 perone to assist their folding and to ensure proper function during viral assembly, maturation, and i

59 f the adult neural stem cell niche to retain proper function even after the removal of major extracel

60 ess: the ability for a system to perform its proper function even as levels of its components change.

61 terminal regions of Rhp26 are needed for its proper function in DNA repair in vivo.

62 tion of Rab GTPases in cells is critical for proper function in membrane trafficking, yet the mechani

63 ted state of SMN, which is important for its proper function in snRNP assembly.

64 des are extensively modified to ensure their proper function in translation.

65 late in erythrocytes, interfering with their proper function in ways that are not yet fully understoo

66 TPases is of fundamental importance to their proper functioning in cells.

67 its initial recruitment to PICs and for its proper functioning in selecting the translational start

68 ly vital for maintaining cellular health and proper functioning in the developing brain.

69 case activity of RNase R is required for its proper functioning in vivo and for effective RNA metabol

70 butes to maintain balance of homeostasis and proper functions in the small intestine, and dysregulate

71 Understanding how proper function is achieved at the atomic level is cruci

72 The human placenta is a complex organ whose proper function is crucial for the development of the fe

73 s highly ordered in the atomic structure and proper function is very sensitive to mutation.

74 For proper function, many sRNAs rely on the chaperone Hfq, w

75 n, and synapse elimination are essential for proper function of a circuit that computes directional m

76 Epithelial tubes are essential for the proper function of a diverse array of eukaryotic organs.

77 lational modifications are essential for the proper function of a number of proteins in the cell.

78 ctional protein involved in the assembly and proper function of a number of tight junctions and is al

79 ead to excitotoxicity which necessitates the proper function of active glutamate transporters.

80 uppressive cytokines that interfere with the proper function of adaptive antitumor immunity.

81 get pathways that are also important for the proper function of antitumor lymphocytes, possibly weake

82 ween axons and Schwann cells is required for proper function of both myelinated and nonmyelinated ner

83 TCC life-cycle alterations, facilitating the proper function of cardiac cells.

84 rane protein localization are crucial in the proper function of cardiac myocytes.

85 ost-derived IL-7 plays a role in driving the proper function of CD4+ T cells in an ACT setting remain

86 Protein quality control is essential for the proper function of cells and the organisms that they mak

87 evidence suggests that both development and proper function of central nervous system require intric

88 in fission yeast, which is essential for the proper function of centromeres.

89 traflagellar transport (IFT) is required for proper function of cilia, although many of the mechanist

90 Neuronal survival is necessary for the proper function of cochlear prosthetics, therefore, it i

91 lic regulation are highly integrated and the proper function of each is dependent on the other.

92 that PPR-RNA mismatches may be essential for proper function of editing factors.

93 ndothelial phenotype and is critical for the proper function of endothelial cells in adult mice.

94 H4B caused by shear is essential in allowing proper function of endothelial NO synthase because GPTCH

95 Proper function of epithelia depends on apically and bas

96 p junction (GJ) organization is critical for proper function of excitable tissues such as heart and b

97 raction partners, which is necessary for the proper function of focal adhesion points.

98 dual actions, vesicular zinc is critical to proper function of hippocampal circuitry in health and d

99 halamic) M(3) receptors are required for the proper function of hypothalamic GHRH neurons.

100 he plasma membrane that was required for its proper function of interacting with F-actin and CD44 as

101 axis that position and are required for the proper function of internal organs.

102 tein required for assembly, maintenance, and proper function of kinetochores during mitosis and meios

103 Photosynthetic light reactions rely on the proper function of large protein complexes (including ph

104 Intraluminal valves are required for the proper function of lymphatic collecting vessels and larg

105 Since the proper function of MADS-box proteins is dependent on spe

106 n of their target ligand is critical for the proper function of many cellular processes.

107 ar communication (GJIC) is essential for the proper function of many organs, including the lens.

108 Proper function of many physiological processes requires

109 stinct shapes and sizes are critical for the proper function of many tubular organs.

110 mouse and zebrafish but are dispensable for proper function of mature olfactory neurons.

111 key cellular processes and in particular for proper function of membrane proteins.

112 lar matrix remodeling mechanism required for proper function of mesenchymal cells.

113 f ergostane-based sterols is crucial for the proper function of mitochondria and the proliferation of

114 The proper function of mitochondria thus depends on folding

115 ular filtration barrier and required for the proper function of nephrin.

116 The proper function of neural circuits requires spatially an

117 inly postnatally, which is important for the proper function of neural circuits.

118 r glycine levels in the CNS is important for proper function of neural networks.

119 citation and inhibition is essential for the proper function of neuronal networks in the brain.

120 Neuronal polarity is crucial for the proper function of neurons.

121 , androgen/AR is required for generation and proper function of neutrophils; androgen/AR also regulat

122 Drosophila melanogaster meiosis requires the proper function of NOD, a nonmotile kinesin-10.

123 We have found that the proper function of NompC, a putative mechanosensitive TR

124 tures, which is critically important for the proper function of on-board automobile fuel cells.

125 portions of the protein that is required for proper function of P1 on the surface of S. mutans.

126 complex regulation in cells to maintain the proper function of p53.

127 t p300/CBP contribute to the development and proper function of pancreatic islets.

128 hat its phosphorylation is important for the proper function of PELP1 in modulating hormone-driven ce

129 Proper function of pharyngeal dilator muscles, including

130 eostasis of the immune system depends on the proper function of regulatory T cells (T(reg) cells).

131 ults suggest that presynaptic plasticity and proper function of RIM1alpha play an important part in a

132 hesis that dimerization is essential for the proper function of sEH, we generated mutations within th

133 The proper function of synapses relies on efficient recyclin

134 We conclude that the proper function of the 5-HT system is particularly impor

135 regulators previously shown to influence the proper function of the actin network.

136 mutant phenotype, but also is sufficient for proper function of the adult heart.

137 maturation of ZTL by HSP90 as essential for proper function of the Arabidopsis circadian clock.

138 Hearing requires proper function of the auditory hair cell, which is crit

139 is thought to ensure correct patterning and proper function of the auditory sensory epithelium.

140 ntrol of neuronal migration is essential for proper function of the brain.

141 n of these receptors is also crucial for the proper function of the cardiovascular, immune, reproduct

142 localization, the C terminus is critical for proper function of the channel sensor and/or gate.

143 priate and defined lengths are necessary for proper function of the cilium.

144 reaction is essential for the integrity and proper function of the CNS.

145 The proper function of the craniofacial skeleton requires th

146 f detected reference gene mRNA confirmed the proper function of the device.

147 lar growth, implicating these factors in the proper function of the Dot/Icm complex.

148 In addition, Ift172 is required for proper function of the embryonic node, the early embryon

149 Proper function of the endoplasmic reticulum (ER) and mi

150 ctivity of the RecB subunit is necessary for proper function of the enzyme both in vivo and in vitro.

151 We conclude that NogoA contributes to the proper function of the ER resident chaperone PDI, and is

152 cient abscission during cytokinesis requires proper function of the ESCRT-III protein IST1, which bin

153 extracellular proteins is necessary for the proper function of the extracellular matrix (ECM) in var

154 ween these bacteria is a requirement for the proper function of the flagellar motor stators that chan

155 Proper function of the glomerular filtration barrier dep

156 glomerular basement membrane is required for proper function of the glomerular filtration barrier.

157 BD3:PI4KB complex formation is essential for proper function of the Golgi.

158 e and adhesion molecules and is vital to the proper function of the immune system.

159 an epithelial chloride channel required for proper function of the lung, pancreas, and other organs.

160 nctional OAS-TL isoform is essential for the proper function of the male gametophyte, although the sy

161 active MBL in body fluids is an indicator of proper function of the MBL pathway.

162 ial metabolism that is essential to maintain proper function of the mitochondria by regulating energy

163 Proper function of the motor unit is dependent upon the

164 neuron is both necessary and sufficient for proper function of the motor unit.

165 Proper function of the MVB pathway requires reversible m

166 and synaptic function.SIGNIFICANCE STATEMENT Proper function of the nervous system requires the estab

167 microglia in instructing and regulating the proper function of the neuronal networks in the adult CN

168 The rhythmic expression and the proper function of the Neurospora FREQUENCY (FRQ) protei

169 l ribosomal proteins (MRPs) are required for proper function of the organelle.

170 human mitochondrial DNA is indispensable for proper function of the oxidative phosphorylation machine

171 gradient-dependent regulatory mechanisms for proper function of the photosynthetic machinery.

172 r envelope protein involved in tethering and proper function of the proteasome.

173 d Mei5 and Sae3 as factors necessary for the proper function of the recombinases Dmc1 and Rad51 in DN

174 encoded transcripts were induced, confirming proper function of the sensitive phytochrome system.

175 dentified as a virulence factor required for proper function of the T3SS.

176 he importance of membrane composition in the proper function of the Tat protein export pathway.

177 al and glial cells) is often crucial for the proper function of the tissue as a whole, yet assessing

178 We conclude that PE is required for the proper function of the TOM complex.

179 at the cell surface and consequently for the proper function of the transporter.

180 se in which the essential exons required for proper function of the Trpa1 gene were deleted.

181 phenotypes such as intestinal colonization, proper function of the type II secretion system, and for

182 us require the translocator protein LcrV for proper function of the type III secretion apparatus, whi

183 the ureters and the trigone are crucial for proper function of the ureteral valve mechanism; however

184 o 48 h and this regeneration is dependent on proper function of the VEGF pathway: siRNA-mediated knoc

185 el quickly and efficiently, allowing for the proper function of the vertebrate nervous system.

186 ho-head of membrane lipids necessary for the proper function of the voltage sensor itself?

187 However, the proper function of these neurons remains to be worked ou

188 uired for transport (ESCRT), a requisite for proper function of this pathway.

189 ncer cells then become very dependent on the proper function of those pathways, and their inhibition

190 tions play only a minor role in ensuring the proper function of tRNAs in E. coli.

191 the native conformation is essential for the proper function of tumor suppressor protein p53.

192 bilize mature protein conformation to ensure proper function of Vif and RUNX1.

193 tion factors controlling the development and proper function of vital organs such as liver, pancreas,

194 itry and brain activity depend critically on proper function of voltage-gated calcium channels (VGCCs

195 ransmigration, as each step necessitates the proper functioning of a distinct set of integrin molecul

196 V infection relies on stable maintenance and proper functioning of a nuclear episomal form of the vir

197 It is required for signalling and proper functioning of a range of proteins involved in, f

198 Proper functioning of an organism requires cells and tis

199 The proper functioning of any biological system depends on t

200 rturbation of key proteins necessary for the proper functioning of autophagy.

201 The proper functioning of biomolecules in living cells requi

202 Although it is clear that proper functioning of both the IGF-1R and NF-kappaB sign

203 els of polyunsaturated phospholipids for the proper functioning of cell membranes.

204 Protein interactions are fundamental to the proper functioning of cells, and aberrant formation or r

205 n is of central importance to the health and proper functioning of cells, and single-cell studies hav

206 lucosamine) transferase SPINDLY required for proper functioning of DELLAs and acts hypostatically to

207 eural circuits or might be necessary for the proper functioning of existing circuits.

208 on of new labels that may interfere with the proper functioning of existing constructs and therefore

209 flexible and turned out to be essential for proper functioning of FtsH as its deletion fully elimina

210 etary ligands in shaping the composition and proper functioning of gut microbiota.

211 n important mineral nutrient essential for a proper functioning of human and animal organism.

212 ription factors is vitally important for the proper functioning of many intracellular signalling path

213 partment, is believed to be essential to the proper functioning of mitochondria as the powerhouse of

214 lux by the TRPM4 channel is critical for the proper functioning of monocytes/macrophages and the effi

215 ergy, commensal bacteria are crucial for the proper functioning of mucosal immune defenses.

216 The organization and proper functioning of myelin can be understood in terms

217 gulating neuronal activity, cardinal for the proper functioning of nervous systems.

218 ry and inhibitory inputs is critical for the proper functioning of neural circuits.

219 meostatic control systems is fundamental for proper functioning of neural circuits.

220 Because a proper functioning of neural network requires phase cohe

221 vidence that endogenous zinc is required for proper functioning of neuronal circuitry in the brainste

222 the neuronal "milieu," which is required for proper functioning of neuronal circuits, synaptic transm

223 at cellular localization is critical for the proper functioning of nucleolin in this pathway and that

224 sulfur (Fe-S) clusters are necessary for the proper functioning of numerous metalloproteins.

225 Nuclear localization is a prerequisite for proper functioning of p53 and our results confirm that T

226 Thus, proper functioning of polymorphic BAF complexes may cons

227 gulation of chain length is essential to the proper functioning of prokaryotic and eukaryotic polysac

228 Proper functioning of sensory systems requires the gener

229 The proper functioning of striatal neurons relies critically

230 lated SYD-1, a synaptic protein required for proper functioning of SYD-2.

231 tained release of dopamine necessary for the proper functioning of target structures, such as the str

232 to produce superoxide and thereby alter the proper functioning of the adjacent arterioles.

233 Proper functioning of the adult nervous system is critic

234 S1P(2) receptor expression is essential for proper functioning of the auditory and vestibular system

235 g A-type K(+) currents are essential for the proper functioning of the brain, where they act to delay

236 opriate synaptic connections is critical for proper functioning of the brain.

237 ediated) synapses is a critical step for the proper functioning of the brain.

238 s and phosphatases, which are central to the proper functioning of the cell.

239 protein interactions are fundamental for the proper functioning of the cell.

240 lly clear; however, their importance for the proper functioning of the cells is unquestionable.

241 biological process that is essential to the proper functioning of the central nervous system.

242 Proper functioning of the centrosome relies on assembly

243 Myelination is essential for proper functioning of the CNS.

244 ropy that is believed to be critical for the proper functioning of the cochlea.

245 stiff endothelial surface is imperative for proper functioning of the endothelium.

246 Our results suggest that proper functioning of the ESX-1 pathway requires the int

247 ing that the CI:MOR complex is essential for proper functioning of the genetic switch.

248 3D genome organization is essential for the proper functioning of the genome.

249 eta2 (LAMB2) is a GBM component required for proper functioning of the glomerular filtration barrier.

250 This ensures proper functioning of the Golgi apparatus in protein tra

251 ut they provide a robust source that permits proper functioning of the gradient in heterozygous embry

252 n the theta range (3-12 Hz) is important for proper functioning of the hippocampus, a brain area esse

253 scriptional regulators are indispensable for proper functioning of the immune system.

254 Proper functioning of the innate immune response depends

255 ion of malate to oxaloacetate as part of the proper functioning of the Krebs cycle.

256 Proper functioning of the mitochondrion requires the orc

257 e conserved kinase Mps1 is necessary for the proper functioning of the mitotic and meiotic spindle ch

258 NA, binding of centromere protein C, and the proper functioning of the mitotic kinetochore.

259 tterning during development is essential for proper functioning of the musculoskeletal system.

260 autophagosome content is crucial to maintain proper functioning of the nervous system.

261 neuronal reactions are important factors for proper functioning of the nervous system.

262 Correct wiring is crucial for the proper functioning of the nervous system.

263 asparagine-linked protein glycosylation for proper functioning of the neuromuscular junction.

264 rtance of N-linked protein glycosylation for proper functioning of the neuromuscular junction.

265 the protein-protein associations that enable proper functioning of the organelle remain largely unkno

266 rol the distribution and storage of iron for proper functioning of the photosynthetic machinery.

267 e juvenile critical window is detrimental to proper functioning of the prefrontal cortex (PFC) and es

268 These cognitive constructs depend on proper functioning of the prefrontal cortex (PFC).

269 s the second zinc finger is essential to the proper functioning of the protein while the remaining zi

270 positive potentials at the pore that enables proper functioning of the protein.

271 eins have been shown to be essential for the proper functioning of the secretion system, and one of t

272 lls, PERK is highly abundant and crucial for proper functioning of the secretory pathway.

273 and 141 affect ubiquinone reduction and the proper functioning of the sodium pump.

274 one of the two salt bridges is critical for proper functioning of the Tol-Pal system.

275 requisite for subunit joining and may ensure proper functioning of the translocation process.

276 ated wastewater reuse, but also for ensuring proper functioning of the treatment plant.

277 Proper functioning of the vertebrate central nervous sys

278 Without proper functioning of these cells, the number, morpholog

279 ional information to contractile arrays, and proper functioning of these gradients is dependent on bo

280 pt their interaction, which is necessary for proper functioning of these two enzymes.

281 % of human cancers, which indicates that the proper functioning of this complex is necessary to preve

282 ol in the mitochondrion is essential for the proper functioning of this organelle.

283 cterium-specific components are required for proper functioning of this regulatory circuit.

284 Oscillatory behaviour is essential for proper functioning of various physical and biological pr

285 t as it forms a local signalling centre, the proper functioning of which is essential for the formati

286 ient transport in plants is dependent on the proper functioning of xylem networks, a series of interc

287 t ciliary dynamics in stem cells require the proper functions of a cholesterol-binding membrane glyco

288 in early development and imperative for the proper functions of the liver, pancreas, and intestines

289 n that scenario as well, supporting that for proper function, proteins must evolve a functional elast

290 Spindle formation and proper function require that microtubules with opposite

291 SCD1 has a diiron center and its proper function requires an electron transport chain com

292 ignin-specific channel is more important for proper functioning than the S lignin-specific channel.

293 To build the OM and ensure its proper function, the cell produces OM constituents in th

294 mplex" (IMAC) at distal tips is required for proper function, the mechanism driving tip accumulation

295 For proper function, these ion channels have to be anchored

296 s, contact inhibition is associated with the proper functioning tissues, whereas abnormal regulation

297 se tissue, enhancing its ability to maintain proper function under metabolically challenging conditio

298 n even wider range of proteins can maintain 'proper' function while immobilized.

299 racellular asparaginase that is required for proper functioning within the cell.

300 This N-terminal tail is indispensable for proper function, yet its solution structure and role in