ライフサイエンスコーパス: prosurvival

1 ss4 (Tss4) possessing anti-inflammatory and prosurvival abilities, as a means for pretransplant gene

2 l-based reporter assays; and antagonized the prosurvival action of BAFF on primary mouse B cells in v

3 roles in cancer and exert proangiogenic and prosurvival activities.

4 ies demonstrate that Dp44mT can overcome the prosurvival activity of autophagy in cancer cells by uti

5 and others have previously demonstrated the prosurvival activity of the PERK pathway in oligodendroc

6 STAT5A and STAT5B exhibited similar prosurvival activity, but STAT5A attenuation alone was i

7 togenesis, which was evoked by enhanced Mcl1 prosurvival activity.

8 SE yet partially inhibited activation of the prosurvival adaptor protein Akt.

9 g: coadministration of immunosuppressive and prosurvival agents, delivery of cardioprotective factors

10 Mer expression was upregulated, prosurvival Akt and mitogen-activated protein kinase sig

11 king mir-155 have impaired activation of the prosurvival Akt pathway after TCR cross-linking.

12 AFi challenge, and decreased the activity of prosurvival AKT signaling.

13 suppressed GSC growth in part by inhibiting prosurvival AKT/mTOR pathways and stimulating proapoptot

14 ne ventral midbrain, together with its known prosurvival and anti-tumorigenic properties, make it a g

15 ative potential with sustained activation of prosurvival and epithelial-mesenchymal transition-signal

16 fied TCTP as a novel mediator of endothelial prosurvival and growth signaling in PAH, possibly contri

17 Toll-like receptor (TLR) complexes promoting prosurvival and inflammatory signaling.

18 lts in the control of genes clustered around prosurvival and proapoptotic functions among others.

19 More than two dozen prosurvival and progrowth kinases dock a conserved pepti

20 In an attempt to diminish their off-target prosurvival and proinflammatory effects and specific del

21 t mechanisms and exhibits kinase-independent prosurvival and proinflammatory functions.

22 ansition, expressions of NF-kappaB-regulated prosurvival and proinflammatory genes, and in vivo radio

23 c serine/threonine kinase that promotes many prosurvival and proinflammatory signaling pathways, incl

24 as6, a Mer ligand, we observed activation of prosurvival and proliferative signaling pathways, includ

25 ate that SH2B1 in beta-cells is an important prosurvival and proproliferative protein and promotes co

26 biologically significant mechanism of vIL-6 prosurvival and proreplication activities via VKORC1v2.

27 te and promotes anti-inflammatory responses, prosurvival, and endothelial barrier stabilization.

28 t of disc disease must spare osmoprotective, prosurvival, and matrix homeostatic activities.

29 e BET inhibitor, modulates proproliferative, prosurvival, and proinflammatory pathways, potentially t

30 e whether MAPK4 activates the key metabolic, prosurvival, and proliferative kinase AKT and mTORC1 sig

31 We postulate that immobilization of the prosurvival angiopoietin-1-derived peptide, QHREDGS, to

32 glycolytic inhibitor 2-deoxyglucose induced prosurvival autophagy.

33 ic leukemia (CLL), signaling through several prosurvival B cell surface receptors activates the PI3K

34 Our work suggests that prosurvival Bcl proteins normally dampen the beta-cell r

35 translation, CR can reduce expression of the prosurvival Bcl-2 family member Mcl-1 and sensitize lymp

36 Besides the well-known reduction of the prosurvival Bcl-2 family member, Mcl-1, following inhibi

37 hen Bax and Bak were present, inhibiting the prosurvival Bcl-2 family members stimulated autophagy, b

38 eins and closely mimics the structure of the prosurvival Bcl-2 family protein Mcl-1.

39 revealed collectively high protein levels of prosurvival Bcl-2 members in cell lines and a panel of M

40 ulatory elements commonly found in mammalian prosurvival Bcl-2 members including Bcl-xL and Mcl-1.

41 K(+)(+)DUSP6(-)) and repressed expression of prosurvival Bcl-2 molecules.

42 Myeloid cell leukemia 1 (MCL-1) is a prosurvival BCL-2 protein family member highly expressed

43 he conserved Bcl-2 fold observed in cellular prosurvival Bcl-2 proteins and closely mimics the struct

44 The prosurvival BCL-2 proteins are attractive yet challengin

45 All 6 human prosurvival Bcl-2 proteins can drive cancer development

46 lineal acute leukemia because of the role of prosurvival BCL-2 proteins in resistance, their imbalanc

47 blish that concurrent inhibition of multiple prosurvival Bcl-2 proteins leads to effective induction

48 t, targeting the ubiquitination machinery of prosurvival Bcl-2 proteins will complement and potential

49 ve cellular interaction profile of all human prosurvival Bcl-2 proteins with all their proapoptotic r

50 olecular strategies including the mimicry of prosurvival Bcl-2 proteins.

51 x activity is controlled in healthy cells by prosurvival Bcl-2 proteins.

52 s inhibition by short-term overexpression of prosurvival BCL-XL, known to block BIM and BMF, is not o

53 ow that the alternative splicing of multiple prosurvival BCL2 family genes promotes malignant transfo

54 suggest that the combinatorial inhibition of prosurvival BCL2 family proteins and BCR-ABL may elimina

55 functional TCRbeta gene (Vbeta1(NT)) or the prosurvival BCL2 protein inhibited death and partially r

56 not a preassembled DbetaJbeta complex or the prosurvival BCL2 protein, completely rescues alphabeta T

57 , which then serves as (auto-) antigen for a prosurvival BCR signal.

58 toxic effects of trastuzumab were owing to a prosurvival benefit of Her2 that binds to neuregulin, wh

59 e level of the mitochondria through a common prosurvival binding groove.

60 re, autophagy induction by antiestrogens was prosurvival but did not prevent ERalpha knockdown-mediat

61 ains of ubiquitin, enabling it to serve in a prosurvival capacity.

62 our data unravel an autonomous STAT3-driven prosurvival circuit that provides circulating CLL cells

63 Yet the nature of potential prosurvival cues has remained unclear.

64 ctions are jointly influenced by Fas and the prosurvival cytokine IL-5.

65 This signaling results in secretion of prosurvival cytokines, such as interferon-gamma-inducibl

66 ressed predominantly IgG, and they carried a prosurvival, distinctly mature phenotype, that is, HLA-D

67 unlike SLPC, CD28 activation in LLPC induces prosurvival downstream Vav signaling.

68 f STAT3 at tyrosine 705 was required for the prosurvival effect because an R26-Stat3(Y705F) allele wa

69 hosphorylation of Akt and suggested that the prosurvival effect can be produced by a cell-autonomous

70 Although S1P possesses a prosurvival effect in beta-cells, an enhanced level of t

71 This was consistent with the loss of CD28's prosurvival effect in LLPC from CD28-AYAA, but not CD28-

72 both promote efferocytosis and override the prosurvival effect of LPS via annexin A1.

73 The prosurvival effect of shPHD2 on ADSCs is hypoxia-inducib

74 The prosurvival effect of Slug was found to be caused by dir

75 NF-kappaB pathway only played a role in the prosurvival effect of TNFR1.

76 This prosurvival effect was attributed to downregulation of F

77 This prosurvival effect was attributed to the MIF-CXCR7-initi

78 ssed nT(reg) generation independently of its prosurvival effect.

79 buted to the CpG motif-mediated, TLR-induced prosurvival effects and inefficient target modulation in

80 tion 3 (STAT3) is perhaps best known for its prosurvival effects in a wide variety of cancers, but fo

81 ein Hspb8, which, because of its pleiotropic prosurvival effects in other systems, was considered a p

82 o promote tumorigenesis, in part because the prosurvival effects of Akt offset the proapoptotic effec

83 incipal mechanism by which Hunk mediates the prosurvival effects of Akt.

84 her, we demonstrate beneficial antitumor and prosurvival effects of anti-Sema4D antibody but also unr

85 erventions with compounds that stimulate the prosurvival effects of autophagy in the vasculature.

86 osis in MM cell lines which can overcome the prosurvival effects of growth factors such as interleuki

87 he Bcl-2 antagonist ABT-199 only reduced the prosurvival effects of HCMV in target monocytes beginnin

88 bling responsiveness of naive T cells to the prosurvival effects of IL-7 and allowing T-cell persiste

89 We could attribute the prosurvival effects to AMPK's ability to maintain redox

90 antagonist, naloxone, was predicted to have prosurvival effects, primarily through angiogenesis, fat

91 op novel therapeutic approaches based on its prosurvival effects.

92 um-binding chaperone in the ER; GRP78/BiP, a prosurvival ER chaperone; and Nrf2, a transcription fact

93 , we herein identified overexpression of the prosurvival factor B cell lymphoma 2 (BCL-2) as a distin

94 ient NKT cells express reduced levels of the prosurvival factor B-cell lymphoma 2 and the integrin ly

95 alpha-deficient B cells still respond to the prosurvival factor BAFF in culture and require BAFF-R si

96 d Stat5 phosphorylation and induction of the prosurvival factor Bcl-2 and the gut homing integrin alp

97 ured by IL-7, which drives expression of the prosurvival factor Bcl-2.

98 In conclusion, we demonstrate that ABA is a prosurvival factor for Mks in a Tpo-independent manner.

99 These findings characterize FBXW7 as a prosurvival factor in B-cell lymphoma via degradation of

100 n myeloid cell leukemia 1 (MCL1), a critical prosurvival factor in cancers such as multiple myeloma w

101 a-crystallin domain might act as pleiotropic prosurvival factor in the adult hippocampus.

102 ls is the stabilization of the mitochondrial prosurvival factor Mcl-1, an SCF(Fbw7beta) target in neu

103 d that NFAT5 regulated the expression of the prosurvival factors A1 and Bcl2 and attenuated the proap

104 red a unique molecular signature enriched in prosurvival factors and tumor suppressors, as well as in

105 th and chemoresistance via downregulation of prosurvival factors Bcl-2 and Bcl-XL that support NF-kap

106 -kappaB- and STAT-dependent transcription of prosurvival factors BCL2A1, BCL2L1, and FCER2.

107 Prosurvival factors of the Bcl-2 family, such as Bcl-xL,

108 n clarified that RelA-dependent synthesis of prosurvival factors restrained infection-inflicted cell

109 as Pd1 and Tim3, and decreased expression of prosurvival factors, including Il7ra.

110 y in cHL that is suggestive of withdrawal of prosurvival factors, rather than induction of an adaptiv

111 MSC proliferation and production of soluble prosurvival factors, such as CXCL12.

112 y may regulate HSC homeostasis through these prosurvival factors.

113 e not suppressed by transgenic expression of prosurvival factors.

114 st apoptosis during prolonged CS/REW by the "prosurvival" factors XIAP and pAkt.

115 )-a negative regulator of both Rheb and Bcl2 prosurvival family members-as a key downstream target of

116 a key role in autophagy; evidence suggests a prosurvival function for autophagy, but other studies pr

117 BZ-treated CTCL cells, indicating TGF-beta1 prosurvival function in CTCL cells.

118 duced 100-fold after DNA damage and exerts a prosurvival function in human colorectal cancer cells (C

119 ells starkly contrasts with its antithetical prosurvival function in plasma cells.

120 These data identify RnR activity as a prosurvival function inactivated by proteolysis during a

121 Our findings uncover a critical prosurvival function of a p53/PINCR/Matrin 3 axis in res

122 Here, we provide evidence for a novel prosurvival function of Bim in cancer cells.

123 is, providing a mechanistic insight into the prosurvival function of DAXX.

124 ther, these data indicate a prohypertrophic, prosurvival function of endogenous YAP and suggest a cri

125 The prosurvival function of IKK centers on activation of the

126 The prosurvival function of the antiapoptotic Bcl-2 proteins

127 In agreement with its prosurvival function, IGF1R inhibition affected the phos

128 based inhibition motifs are required for its prosurvival function.

129 d oxidative stress points to gamma-tubulin-2 prosurvival function.

130 However, the majority of the prosurvival functions of hUTC-conditioned media was spar

131 n-inhibiting cochaperones exerting essential prosurvival functions.

132 tly, overexpression of Bcl2, a mitochondrial prosurvival gene and target of IL-7R signaling, partly r

133 n A20 mutant HL cells, which is required for prosurvival genes and immunosuppressive molecule express

134 neuron survival through the upregulation of prosurvival genes and inhibition of microglial inflammat

135 cient cells by suppressing expression of the prosurvival genes Bcl2 and Mcl1.

136 ts indicate that PRMT5 governs expression of prosurvival genes by promoting WNT/beta-CATENIN and AKT/

137 ction and spread, some viruses have co-opted prosurvival genes from the host.

138 Prosurvival genes that are preferentially expressed in C

139 lanocytes had little impact on expression of prosurvival genes, instead inducing Mitf Thus, BAP1 appe

140 tor, which was vital for normal induction of prosurvival genes, suppression of proapoptotic genes, nu

141 and promote the expression of progrowth and prosurvival genes.

142 athogenic cooperation among NF-kappaB-driven prosurvival, genetic instability, and immune evasion mec

143 For example, interference of the prosurvival IGF-I/AKT/FOXO3 pathway by redox activation

144 rinsic inflammatory pathways associated with prosurvival in basal-like breast cancer.

145 In contrast, intact GSN (I-GSN) was prosurvival in the presence of CDDP through a FLICE-like

146 atic islet, IL-6 stimulates secretion of the prosurvival incretin hormone glucagon-like peptide 1 (GL

147 helial cells (EC) triggers proliferative and prosurvival intracellular signaling, which is implicated

148 Furthermore, inactivation of the prosurvival kinase Akt is a key step in its neurotoxic s

149 These microRNAs activated prosurvival kinases and induced a glycolytic switch in r

150 Once in the cytoskeleton, GBP1 binds to prosurvival kinases such as PIM1 and initiates a signali

151 in the ER compartment.IMPORTANCE HHV-8 vIL-6 prosurvival (latent) and proreplication functions are me

152 PRC2 subunit genes and several prosurvival lymphoma genes were unmethylated and overexp

153 Abundant, sustained expression of prosurvival Mcl-1 is an important determinant of viabili

154 ese results describe a novel, bidirectional, prosurvival mechanism between AML blasts and BM-MSCs.

155 ndings elucidate YAP binding to dendrin as a prosurvival mechanism.

156 THBS1 and MANF degradation and loss of this prosurvival mechanism.

157 ronmental insults possess cell type-specific prosurvival mechanisms or enhanced DNA damage repair cap

158 cating that these responses are triggered as prosurvival mechanisms that enable cells to tolerate the

159 y, further underlining the role of AMPK as a prosurvival mediator.

160 stically, ATM mediates crosstalk between the prosurvival MEK/ERK and AKT/mTOR pathways.

161 his process is regulated by proapoptotic and prosurvival members of the B-cell lymphoma 2 (Bcl-2) pro

162 up-regulation of Mcl1 and Bcl2a1, which are prosurvival members of the Bcl-2 family.

163 ed by interactions between pro-apoptotic and prosurvival members of the Bcl-2 family.

164 exocytosis and sustained phosphorylation of prosurvival, metabolic pathways.

165 Interestingly, UVB initiated a prosurvival mitophagy response by mitochondria-mediated

166 's effects on caspase-9 activity promote the prosurvival mode.

167 tutively overexpressed Bim may function as a prosurvival molecule in epithelial cancer cells, and pho

168 rylated by sphingosine kinase to produce the prosurvival molecule sphingosine-1-phosphate.

169 s, suggesting that MCL-1 may be an essential prosurvival molecule.

170 The upregulated expression of prosurvival molecules in turn inhibited target cell dest

171 vival and NF-kappaB-mediated upregulation of prosurvival molecules is a well-documented protective me

172 for these disorders, and (iii) indicate that prosurvival molecules whose expression is increased in m

173 rgistically promoted the expression of these prosurvival molecules, preventing cellular apoptosis at

174 reasing the translation of proliferative and prosurvival mRNAs.

175 BCR (My-T-BCR) supercomplex, which initiates prosurvival NF-kappaB activation.

176 Prosurvival NF-kappaB pathway activation characterized h

177 function was the result of activation of the prosurvival NF-kappaB pathway, which was mediated by RET

178 ng cooperates with BCR signaling to activate prosurvival NF-kappaB.

179 APTi exploits the prosurvival output of transiently silencing APT in the p

180 ere with the ability of trastuzumab to block prosurvival p-Akt signaling.

181 ha-helical structure and bind to a groove on prosurvival partners Bcl-xL, Bcl-w, Bcl-2, Mcl-1 and Bfl

182 n of these receptors blocks the Akt/GSK3beta prosurvival pathway and activates the apoptotic cascade,

183 ortant Traf2-mediated, NFkappaB-independent, prosurvival pathway in the heart by suppressing necropto

184 oreover, we detected a similarly functioning prosurvival pathway involving phosphorylated CD19 and PI

185 ERK pathway, which frames the conundrum of a prosurvival pathway that kills cells.

186 Proteome analyses revealed a defective prosurvival pathway via PI3K/protein kinase B (Akt1)/Bcl

187 ical utility of agents targeted against this prosurvival pathway.

188 roliferative pathway as well as the PI3K-AKT prosurvival pathway.

189 nmutational mechanisms of resistance such as prosurvival pathways and bone marrow signaling may be up

190 RNA target genes are co-regulated members of prosurvival pathways associated with cellular regenerati

191 This in turn down-regulates prosurvival pathways like NF-kappaB, leading to inhibiti

192 een attributed to Akt-induced stimulation of prosurvival pathways that indirectly antagonize the effe

193 roptotic phospholipids triggers compensatory prosurvival pathways, and in particular autophagic pathw

194 tic breast cancer model cell lines inhibited prosurvival pathways, shifted the balance of Bcl-2 famil

195 unique MEK5/ERK5, p90Rsk, and Akt-dependent prosurvival pathways, ultimately leading to enhanced exp

196 and chemokine receptors, which could mediate prosurvival pathways.

197 n this study, we present an integrin-binding prosurvival peptide derived from angiopoietin-1, QHREDGS

198 transcription factor Twist1 may explain this prosurvival phenotype in vitro.

199 In contrast, the prosurvival phenotype of patient cells was resistant to

200 hed that FAK inactivation served to unmask a prosurvival phosphoinositide 3-kinase/AKT-dependent sign

201 varian cancer cell line capacity to activate prosurvival PI3K signaling in response to ligand, which

202 tor(s) and integrins during induction of the prosurvival PI3K-AKT pathway by heparanase.

203 eby greatly augmenting signaling through the prosurvival PI3K/Akt pathway.

204 T can arise from increased expression of the prosurvival Pim protein kinases.

205 veolar neutrophils display a distinct primed prosurvival profile and transcriptional signature.

206 bility to exhibit both antiproliferative and prosurvival properties by facilitating translation of mR

207 hese results support the notion that HuR has prosurvival properties in PDA cells by enabling them wit

208 of the pleiotropic factor RelA linked to its prosurvival properties.

209 Prosurvival protein BCL-2 is overexpressed in estrogen r

210 anscriptional output and upregulation of the prosurvival protein BCL-2.

211 Our results identify MCL-1 as a critical prosurvival protein for preventing beta-cell death and c

212 Here, we report that the fowlpox virus prosurvival protein FPV039 promiscuously binds to cellul

213 horylation and results in rapid loss of this prosurvival protein in chemoresistant cancer cells.

214 One such viral prosurvival protein is the fowlpox virus protein FPV039,

215 t UPEC abrogates activation of the host cell prosurvival protein kinase B signaling pathway, which re

216 his signal is essential for the induction of prosurvival protein Mcl-1 and precursor cell survival.

217 ulted in rapidly decreased expression of the prosurvival protein Mcl-1, and accordingly, overexpressi

218 tosis was preceded by down-regulation of the prosurvival protein Mcl-1, with proteasomal inhibition p

219 resulting in selective downregulation of the prosurvival protein MCL1.

220 s to demonstrate that GrB cleaves ITSN-1s, a prosurvival protein of lung ECs, and generates two biolo

221 eam, Trib3 interferes with the PD-associated prosurvival protein Parkin to mediate death.

222 protein 4 (BRD4)-dependent expression of the prosurvival protein survivin (BIRC5) and attenuation of

223 at Trib3 physically interacts with Parkin, a prosurvival protein whose loss of function is associated

224 protein, and 22 peptides bound at least one prosurvival protein with a dissociation constant between

225 em and D443rVem, increased activation of the prosurvival protein, AKT, and the MAPKs, ERK, JNK, and P

226 ed evidence of interaction with at least one prosurvival protein, and 22 peptides bound at least one

227 ncreased apoptosis through downregulation of prosurvival proteins Bcl-2 and Mcl-1.

228 We observed up-regulation of prosurvival proteins Bcl-xL and Mcl-1, which sequester B

229 ides for interaction with one or more of the prosurvival proteins Bcl-xL, Bcl-w, Bcl-2, Mcl-1 and Bfl

230 hondrial") apoptosis pathway by BCL-2 family prosurvival proteins for their development and viability

231 AT3-dependent mRNA and protein expression of prosurvival proteins in the selectively vulnerable CA1.

232 l-2 can mediate interactions between Bax and prosurvival proteins inside the membrane in the absence

233 We investigated the importance of the prosurvival proteins myeloid cell leukemia-1 (MCL-1) and

234 therapeutic potential of directly inhibiting prosurvival proteins was unveiled with the development o

235 This family comprises proapoptotic and prosurvival proteins, and shifting the balance toward th

236 odulation, intracellular signaling pathways, prosurvival proteins, and the tumor microenvironment.

237 apoptosis resistance induced by the upstream prosurvival proteins.

238 ated in mutant BRAF melanoma as an adaptive, prosurvival response to FDA-approved RAF inhibitors.

239 he one hand, autophagy might be induced as a prosurvival response to therapy, thereby reducing treatm

240 This prosurvival response was partially mediated through enha

241 s required for key roles in phagocytosis and prosurvival responses of macrophages.

242 , and CCL20 expression) without compromising prosurvival responses.

243 ate degradation of AML1-ETO but rather has a prosurvival role in AML cells, as inhibition of autophag

244 This prosurvival role of BAP1 depends on its de-ubiquitinatin

245 The prosurvival role of enhanced Stat3 activity was validate

246 a cells during oxidative stress may denote a prosurvival role of gamma-tubulin-2 in neurons.

247 ymocytes and as a downstream effector of the prosurvival role of the pre-T-cell receptor.

248 We noted that AMPK localization has a prosurvival role, as AMPK silencing decreased cellular g

249 3aR both play powerful anti-inflammatory and prosurvival roles during systemic infection with L. mono

250 nction of p53 metabolic genes, others reveal prosurvival roles of those targets in both tumor and nor

251 c-Abl plays both proapoptotic and prosurvival roles, and our findings suggest that c-Abl's

252 expressed in CMLSCs is PIM2, which encodes a prosurvival serine-threonine kinase that phosphorylates

253 We show that ERAS expression elicits a prosurvival signal associated with phosphorylation/inact

254 F-alpha secretion which, in turn, provided a prosurvival signal.

255 NMDAR-mediated, bidirectional regulation of prosurvival signaling (i.e. the cAMP response element-bi

256 TRAF1, a prosurvival signaling adaptor required for 4-1BB-mediate

257 ous factor that controls the balance between prosurvival signaling and apoptosis in hepatocytes in AP

258 or-1 (IGF-1), which activates IGF-1 receptor prosurvival signaling and improves cardiac left ventricu

259 TBK1 reportedly mediates prosurvival signaling by activating NF-kappaB and AKT.

260 We specifically found that TRAIL induces prosurvival signaling by increasing the phosphorylation

261 e (Hunk), which serves as an effector of Akt prosurvival signaling by suppressing c-myc expression in

262 human tendon scar samples displayed enhanced prosurvival signaling compared to control tissue.

263 Prosurvival signaling derived from the microenvironment

264 end-joining DNA repair pathway and provides prosurvival signaling during DNA damage.

265 hanism between STAT3 and PRL-3 that prolongs prosurvival signaling in multiple myeloma, and suggest t

266 herapeutic resistance through a compensatory prosurvival signaling mechanism.

267 identified Yes-associated protein (YAP) as a prosurvival signaling molecule, the in vitro silencing o

268 Gal-I levels exhibit increased activation of prosurvival signaling molecules, including pAkt, p-p70S6

269 CK1alpha suppression inhibits the NF-kappaB prosurvival signaling pathway.

270 Although NF-kappaB initiates prosurvival signaling pathways post-IR, the molecular fu

271 f extracellular glutamate and an increase of prosurvival signaling pathways.

272 ecent studies link KLF4 and KLF5 to adaptive prosurvival signaling responses induced by HER2-targeted

273 2A or GluN2B attenuated the up-regulation of prosurvival signaling triggered by the activation of eit

274 sis in breast cancer cells but also elicited prosurvival signaling via an EGF receptor/phosphoinositi

275 Prosurvival signaling was identified as a therapeutic vu

276 nhanced EPC proliferation, angiogenesis, and prosurvival signaling while inhibiting EPC senescence.

277 In addition to deactivation of prosurvival signaling, cetuximab-mediated EGFR targeting

278 her, these data indicate that in addition to prosurvival signaling, insulin action in early life medi

279 rutinib to dually target BTK to suppress its prosurvival signaling.

280 nd EGFR/EGFRvIII suppressed their downstream prosurvival signaling.

281 mplex 2 (mTORC2), resulting in activation of prosurvival signaling.

282 Janus kinase 1 supported a role for IL-10 in prosurvival signaling.

283 n FADD-mediated cell death and IL-5-mediated prosurvival signaling.

284 CD8 T cell immunity in the mucosa when other prosurvival signals are limiting.

285 In accordance, strong prosurvival signals delivered through ectopic expression

286 se results indicate that BPTF transduces key prosurvival signals driven by MITF, further supporting i

287 -145, antagonizes BCR crosslinking activated prosurvival signals in primary CLL cells.

288 we show that integrin alphavbeta3 transduces prosurvival signals into TCL nuclei, suggesting a novel

289 eta CAR activation, which indicates distinct prosurvival signals mediated by the 4-1BB cytoplasmic do

290 ignals, we show that GSK3 inhibition induces prosurvival signals through increased activity of the au

291 These cells provide prosurvival signals to tumors; however, little is known

292 ising strategy to promote astrocyte-secreted prosurvival signals.

293 appaB, thereby dampening proinflammatory and prosurvival signals.

294 he cellular balance between proapoptotic and prosurvival sphingolipids.

295 XBP1 mRNA, which is ligated to code for the prosurvival transcription factor.

296 in immunoregulatory proteins is modulated by prosurvival transcription factors, such as NFkappaB and

297 was mediated by the reduced activity of the prosurvival transcriptional regulator Yes-associated pro

298 stine, epithelial HuR promotes expression of prosurvival transcripts that support Wnt-dependent tumor

299 of transcriptionally active ATF6, improving prosurvival UPR function in striatal neurons.

300 l types, its links with other mediators, its prosurvival versus activation/differentiation functions,