ライフサイエンスコーパス: protection against

1 anges in potency of siRNAs and the increased protection against 5'-exonuclease degradation afforded b

2 7N9 virus infection, while the variant loses protection against a group 1 H5N1 virus.

3 sporozoites (CVac) with chloroquine induces protection against a homologous Plasmodium falciparum sp

4 utaneous bolus injections, and led to immune protection against a lethal bacterial dose.

5 /-) mice, neither NS1-based vaccine provided protection against a lethal high dose (10(5) PFU) ZIKV c

6 The role of antibodies in protection against a primary Chlamydia infection is uncl

7 it has been suggested that they provide host protection against a variety of noxious environmental su

8 used to vaccinate mice, it provided enhanced protection against a wild-type Cal/09 challenge relative

9 Vaccination offered no protection against A(H1N1)pdm09 viruses with antigenical

10 xtracellular hydrophobic layer that provides protection against abiotic and biotic stresses and preve

11 on IL-22 signaling, pathways responsible for protection against acute stressors.

12 base pairs in dsDNA only conferred ~130-fold protection against adenine-N1 methylation, and this prot

13 Apolipoprotein L-1 (APOL1) provide increased protection against African trypanosome parasites while a

14 for severe hemophilia A by providing optimal protection against all bleed types, with less frequent d

15 , with no single immune parameter predicting protection against all clinical outcomes and stages of H

16 4CMenB has the potential to provide some protection against all meningococcal serogroups.

17 for a prophylactic vaccine that would confer protection against all of these viruses that cause letha

18 In the Protection against Allergy: Study in Rural Environments

19 that ATG16L1 and other ATG proteins mediate protection against alpha-toxin through the release of AD

20 uction of heat shock proteins (HSPs) confers protection against aminoglycoside-induced hair cell deat

21 demonstrated that IL-10 was not required for protection against anaphylaxis.

22 ethal, heterozygous mice are viable and show protection against aneurysm and injury-induced neointima

23 ovar to engage with and consequently provide protection against another Salmonella serovar is determi

24 The GFP-DDDHA strain also provides cross-protection against another T. cruzi isolate.

25 e interval, 3.4-43.4%) and 11.4% (4.0-18.6%) protection against antibiotic-treated episodes of acute

26 rsion (IgA >= 20 U/mL) conferred substantial protection against any and severe rotavirus gastroenteri

27 ecause the mechanisms that underlie antibody protection against any virus have a theoretical potentia

28 We did not identify strong evidence of protection against atypical respiratory symptoms.

29 e attenuated BPZE1 vaccine candidate induces protection against B. pertussis and prevents nasal colon

30 prospects of improving vaccine efficacy and protection against B. pertussis transmission.TRIAL REGIS

31 be an attractive target for vaccine-induced protection against bacterial infections because of their

32 he circadian clock in beta-cells will confer protection against beta-cell dysfunction under diabetoge

33 fore, although GC-1 treatment induces a mild protection against biliary injury in the early stages of

34 ng in glutamatergic neurons is necessary for protection against body weight gain and induction of UCP

35 cking Pdcd1 (Pd1-/-) demonstrated remarkable protection against bone destruction induced by femoral i

36 nsfer of CD4(+) T cells alone confers marked protection against Brucella melitensis that is abrogated

37 ated whether B cells inhibit T cell-mediated protection against Brucella Using B and T cell-deficient

38 oclonal antibodies (Ab) can provide complete protection against bubonic plague in animal models, the

39 ntation pathway is required for PIV-mediated protection against C. burnetii infection.

40 caspase-1 failed to induce colitis or confer protection against C. rodentium infection due to subopti

41 We measured PCV-conferred protection against CAAP attributable to vaccine-serotype

42 Among children, PCV-conferred protection against CAAP attributable to vaccine-targeted

43 We measured PCV-conferred protection against carriage of vaccine-serotype pneumoco

44 to evaluate the capacity of EPIT to provide protection against cashew-induced anaphylaxis in a relev

45 We report here the successful protection against CCHFV-mediated disease in a non-human

46 The extent and duration of protection against CDI later in life afforded by natural

47 vancements in MOF-based adsorbent design for protection against chemical warfare agents (organophosph

48 the availability of a food source or provide protection against chemical, radiation or thermal stress

49 vector control and provide better community protection against clinical malaria in pyrethroid-resist

50 ole for PI3K signaling in Treg cell-mediated protection against CNS inflammation.

51 itopes), which is likely to provide enhanced protection against complex candida antigens.

52 tibodies provide an alternative strategy for protection against congenital ZIKV infection without cau

53 vaccine (PfSPZ Vaccine) has shown up to 100% protection against controlled human malaria infection (C

54 ory immune responses is essential to promote protection against coronavirus infection; however, the u

55 We propose that the highest protection against counterfeit medicines would be a comb

56 A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age o

57 l likely prove critical for long-term immune protection against COVID-19.

58 ass I (MHC-I) and MHC-II in vaccine-mediated protection against Coxiella burnetii, we evaluated the p

59 ed to determine if AMP upregulation provides protection against CS-associated diseases later in life.

60 Genetic deletion of C5aR1 in mice conferred protection against diabetes-induced renal injury.

61 ive IgE sensitization, and resulted in cross-protection against different allergens.

62 vaccine candidates may be needed to provide protection against different Ebola species and to extend

63 response, which is associated with a lack of protection against disease during reinfection.

64 e onset/exacerbation due to a "poor" diet or protection against disease with a "healthy" diet.

65 mmunological memory able to induce long-term protection against disease.

66 eloping effective immune-based therapies for protection against diseases that involve recruitment of

67 Memory CD8 T cells provide durable protection against diverse intracellular pathogens and c

68 ccination does not always guarantee complete protection against drifted or, more noticeably, shifted

69 nance of the intestinal barrier and provides protection against DSS-induced colon injury.

70 Herein we review immune correlates of protection against each of these end points in turn, sho

71 Monoclonal antibodies can mediate protection against Ebola virus (EBOV) infection through

72 understanding of the putative correlates of protection against EBOV.

73 NK cell proliferation but is dispensable for protection against ECTV and MCMV, two well-established m

74 but also provide at least interim effective protection against emerging bacterial infections.

75 Efficient host protection against enteropathogenic bacterial infection

76 against a commensal Pantoea species confers protection against enterotoxigenic E. coli in pups.

77 diverse capsular polysaccharides (CPSs) for protection against environmental and host factors, inclu

78 e for thioredoxin reduction and a reversible protection against excessive oxidation of the catalytic

79 n function of HR(+)-ETP-derived DCs sustains protection against experimental allergic encephalomyelit

80 acquisition, colonization and invasion, and protection against external toxic threats such as antibi

81 or or mitogen to HSCs in our models, and the protection against fibrosis by FGF15 deficiency may be m

82 , is capable of inducing variable degrees of protection against flavivirus infection in animal models

83 challenging because vaccines have to provide protection against four different dengue virus stereotyp

84 Then, brain protection against further toxic insults would be jeopar

85 ng will show whether these responses predict protection against future infections.

86 ATP13A2 offers protection against genetic and environmental risk factor

87 D8 T cells to the vaginal mucosa and provide protection against genital herpes infection in mice.

88 ecrease in advance glycated end products and protection against glycoxidation-induced protein conform

89 aceae and Bacteroidetes were associated with protection against gram-negative bloodstream infection.

90 licited by the gN38 variant provide complete protection against group 2 H7N9 virus infection, while t

91 HPV vaccine was associated with substantial protection against GWs in girls vaccinated at age <=16 y

92 indicate that infection induces durable sero-protection against H1N1pdm09 but not H3N2Pe09, which cou

93 It provides protection against hazardous particles such as bacteria

94 s of haptoglobin are insufficient to provide protection against Hb-driven disease processes in condit

95 efined in vitro have been proposed to confer protection against HCMV infection, and the virion envelo

96 mune responses are typically associated with protection against helminth infections and also with har

97 inct tissue environments and are crucial for protection against helminth infections and for the maint

98 ral killer (NK) cells play critical roles in protection against hematological malignancies but can ac

99 uating tradeoffs among light, nutrients, and protection against herbivores.

100 ctive fertilization of their crops and their protection against herbivory.

101 allow plants to recruit natural enemies for protection against herbivory.

102 ed vaccine imprints AwM, conferring enhanced protection against heterologous bacterial challenge.

103 The potential for BCG to provide protection against heterologous infections, by induction

104 termed trained immunity, contributes toward protection against heterologous infections.

105 acillus Calmette-Guerin (BCG) contributes to protection against heterologous infections.

106 e important for generating antibody-mediated protection against highly variable pathogens.

107 shown in other cohorts to be associated with protection against HIV disease progression, but studies

108 HLA-B*52:01 is strongly associated with protection against HIV disease progression.

109 irus assays, demonstrating complete in vitro protection against HIV-1 infection.

110 hether blood-stage parasite exposure impacts protection against homologous controlled human malaria i

111 Current influenza vaccines only confer protection against homologous viruses.

112 rNDV expressing HA protein provided complete protection against HPAIV challenge.

113 rs), assuming 90% coverage and 100% lifetime protection against HPV types 16, 18, 31, 33, 45, 52, and

114 ltagD-2) that induces ADCC provided complete protection against HSV disease and prevented the establi

115 ose that maternal immunization could provide protection against HSV for both mother and baby.

116 Identification of correlates of protection against human influenza A virus infection is

117 In the absence of a correlate(s) of protection against human tuberculosis and a validated an

118 ical for normal growth in vitro and provides protection against hydrogen peroxide, bleach, and ciprof

119 The belief that this behaviour confers protection against ill health [3] is supported by the de

120 Vaccine protection against illness from A(H1N1)pdm09 was lower t

121 a more diverse antibody response and broader protection against infection and disease.IMPORTANCE Resp

122 (2019) are setting new benchmarks for protection against infection and pulmonary disease by ch

123 ral killer cells provided the most effective protection against infection in these transfer experimen

124 TB case contacts to understand their role in protection against infection with Mycobacterium tubercul

125 ging to design a vaccine that provides broad protection against infection.

126 past antigen exposure can confer long-lived protection against infections or tumors.

127 ination was assumed to provide 100% lifetime protection against infections with HPV types 16, 18, 31,

128 dNK facilitate trophoblast invasion, provide protection against infections, and were shown to have ma

129 on of intracellular microorganisms, and host protection against infectious diseases(1,2).

130 ssential role of Fam3D in colon homeostasis, protection against inflammation associated cancer and no

131 udies, sirtuin 1 (SIRT1) was associated with protection against inflammation.

132 ltivalent influenza vaccine products provide protection against influenza A(H1N1)pdm09, A(H3N2), and

133 ld be employed to monitor and develop robust protection against influenza B morbidity and mortality.

134 bodies to the influenza virus NA can provide protection against influenza disease.

135 er Xcr1 or Clec9A induced full and long-term protection against influenza infection, whereas only par

136 offering great potential for rapid and broad protection against influenza reinfection.

137 zed with rewired virus vaccines shows better protection against influenza virus challenge.

138 tion in pregnant women, and association with protection against influenza virus illness.

139 Humoral immune protection against influenza virus infection is mediated

140 tivity, all of which have been implicated in protection against influenza, have yet to be defined.

141 mmune response provides specific, long-lived protection against invading pathogens, via immunoglobuli

142 d serum-active system critical for providing protection against invading pathogens.

143 alphaCD47Ab conferred the greatest protection against IRI in mice after 24 hours.

144 verexpression of these two factors conferred protection against ischemic injury in mature mouse heart

145 ng and lateralization of Cx43 immunosignals, protection against isoproterenol-induced arrhythmias, an

146 nonpathogenic in humans but able to provide protection against Junin virus (JUNV), the causative age

147 the adaptor protein, SKAP2, is required for protection against K. pneumoniae (ATCC 43816) pulmonary

148 ould be harnessed to confer population-level protection against K. pneumoniae infection.

149 Influenza vaccination gave meaningful protection against laboratory-confirmed influenza in peo

150 Trained immunity confers broad-spectrum protection against lethal bacterial infections.

151 Additionally, 14B10 or NA9D7 provide 100% protection against lethal CVA16 infection in a neonatal

152 38-1-10A and 38-3-11A both confer effective protection against lethal EV71 challenge in hSCARB2-tran

153 d orally bioavailable, and provided complete protection against lethal infection in a Sendai virus mo

154 n-resistant GRFT (Q-GRFT) showed significant protection against lethal NiV challenge in Syrian golden

155 indicating that T. ovis confers heterologous protection against lethal T. lestoquardi infection.

156 safe, highly immunogenic, and provided full protection against lethal ZIKV challenge.

157 rgD-2-vaccinated, mice provided significant protection against lethality in passive transfer studies

158 those vaccinated with all 3 toxoids had 100% protection against lethality.

159 rant investigation as potential mediators of protection against LOD.

160 Protection against M. tuberculosis infection was strongl

161 ndings underscore the significance of CSP in protection against malaria pre-erythrocytic stages and d

162 arasite-specific antibodies are critical for protection against malaria, yet the development of long-

163 s are innate immune cells essential for host protection against malaria.

164 accines could confer better and more durable protection against malaria.

165 ith non-malarial effects) to achieve greater protection against malarial and non-malarial causes of l

166 een proposed as a potential key mechanism of protection against many viral pathogens, antibodies medi

167 rinsic adrenergic signaling was required for protection against MCMV.

168 lation of a threonine and is associated with protection against MDD, mainly in women.

169 n models were constructed to estimate direct protection against MenW disease offered by the infant 4C

170 Here, we investigate how ATP13A2 provides protection against mitochondrial toxins such as rotenone

171 modulate innate immune responses and lead to protection against mortality from unrelated infections (

172 d neutralizing human PfCSP mAbs at mediating protection against mosquito bite challenge in mice.

173 e autophagy protein ATG16L1 is necessary for protection against MRSA strains encoding alpha-toxin(4)-

174 is study, we aimed to identify correlates of protection against Mtb infection.

175 d in disease protection correlates of immune protection against Mtb.

176 IgG derived from breast milk was crucial for protection against mucosal disease induced by enterotoxi

177 viors capable of providing enhanced personal protection against multiple mosquito-borne infectious di

178 ll evaluate the ability to provide prolonged protection against multiple virus challenges, and differ

179 LKBH7 regulates glyoxal metabolism, and that protection against necrosis and cardiac IR injury bought

180 ntibodies mediating ADCC provide significant protection against neonatal HSV.

181 tified defects in intracellular survival and protection against neutrophil killing.

182 impacts on immune responses to influenza and protection against new influenza A subtypes (phenomena k

183 need is greatest, and does not confer cross-protection against newly emerging phylogroup II lyssavir

184 t female, mice also exhibited ISRIB-mediated protection against noise-induced suprathreshold ABR wave

185 tuberculosis (TB), and is thought to provide protection against non-TB infectious diseases.

186 caused by environmental factors and provides protection against nonstomatal water loss.

187 oxidation of the active center leads to the protection against O(2)-induced degradation.

188 After observing protection against obesity-induced neuroinflammation and

189 Thus, ME may offer protection against offspring HFD-induced NAFLD by shapin

190 ited by bacteria and phages, while affording protection against one another, also provide evolutionar

191 NAc pathway during retrieval causes enduring protection against opiate-primed relapse.

192 While neutralization has been linked to protection against other pathogens, whether neutralizati

193 on or immunization with one serovar provides protection against other serovars has not been well stud

194 n only support a health claim concerning the protection against oxidative stress depending on the pol

195 otif and its capacity for providing cellular protection against oxidative stress while serving as a r

196 o hydrogen peroxide and are important in the protection against oxidative stress.

197 e first IPTp-SP dose fail to provide optimal protection against P. falciparum, especially submicrosco

198 induced humoral immune responses and drived protection against parasite challenge infection.

199 Naturally acquired protection against partially heterologous types suggests

200 The human skin is a significant barrier for protection against pathogen transmission.

201 ibodies are key immune effectors that confer protection against pathogenic threats.

202 in sub-Saharan Africa because they conferred protection against pathogenic trypanosomes that cause Af

203 onents of the innate immune system providing protection against pathogens.

204 rowth, the entry of beneficial microbes, and protection against pathogens.

205 We found modest protection against PCR-confirmed pertussis among older a

206 Protection against PCV13-serotype and PCV7-serotype CAAP

207 40% (95% CI, 4-67%) and 62% (95% CI, 33-83%) protection against PCV13-serotype colonization at ages 1

208 Estimates suggested greater PCV13-conferred protection against PCV7-targeted serotypes than the 6 PC

209 nization or infection with Chlamydia confers protection against per-vaginal (p.v.) challenge, resulti

210 , is associated with immune surveillance and protection against peritoneal contaminants.

211 d CRISPR-Cas, that provide sequence-specific protection against phage infection.

212 rikingly, SspABCD coupled with SspE provides protection against phages in unusual ways: (1) SspE sens

213 e clock protein BMAL1 in macrophages confers protection against pneumococcal pneumonia.

214 ion and inflammation in the lung, indicating protection against pneumonia.

215 aequisignata) wing cases, provides effective protection against predation by birds.

216 considered to substitute for conspecifics as protection against predators at a significantly reduced

217 uctures extending from grass lemmas, provide protection against predators, contribute to photosynthes

218 t, acts as a significant mediator of cardiac protection against pressure overload-induced pathologica

219 it a mixed Th1 and Th17 response and confers protection against pulmonary coccidioidomycosis in mice.

220 te-Guerin (BCG) vaccination induces variable protection against pulmonary tuberculosis (TB), and a mo

221 Viant et al. address the real-world issue of protection against rapidly emerging pathogen variants an

222 infection was significantly associated with protection against reinfection (Fisher's exact test, P =

223 Such antibodies provide protection against reinfection by the same strain of a p

224 widespread serological testing and antibody protection against reinfection with SARS-CoV-2, and may

225 memory T cell qualities and conferred robust protection against reinfection.

226 This attenuated strain induces very strong protection against reinfection.

227 Immunological memory is required for protection against repeated infections and is the basis

228 ng antibody (bNAb) 10-1074 conferred durable protection against repeated penile exposures to simian-h

229 or 3BNC117 alone, also exhibited significant protection against repeated vaginal SHIV(AD8-EO) exposur

230 Xingu blackberry, its antioxidant capacity, protection against ROS generation, and compare it with o

231 ) as an individual-level immune correlate of protection against rotavirus gastroenteritis.

232 an immunization program provides significant protection against rotavirus-associated hospitalization

233 neutralizing antibody and provided complete protection against RSV replication.

234 din-mediated immune evasion can promote host protection against S. aureus bloodstream infection.

235 ility that dengue might induce immunological protection against SARS COV-2.

236 These data demonstrate vaccine protection against SARS-CoV-2 clinical disease.

237 data demonstrate robust single-shot vaccine protection against SARS-CoV-2 in non-human primates.

238 These data demonstrate vaccine protection against SARS-CoV-2 in nonhuman primates.

239 ively low antibody titres are sufficient for protection against SARS-CoV-2 in rhesus macaques, and th

240 ralization alone will be sufficient to drive protection against SARS-CoV-2 in the broader population

241 e risks and opportunities for antibody-based protection against SARS-CoV-2.

242 isease and are nonredundant or redundant for protection against SARS-CoV-2.

243 immune memory induced by beta-glucan confers protection against secondary infections, its impact on a

244 blood cell polymorphisms that confer innate protection against severe disease.

245 E756del variant is strongly associated with protection against severe malaria in heterozygotes.

246 ttings, seroconversion provided near perfect protection against severe rotavirus gastroenteritis (HR,

247 accine-microbicide combination would enhance protection against SIV infection in rhesus macaques.

248 immunologic mechanisms that provide durable protection against skin infections has the potential to

249 To balance biodiversity protection against society's economic objectives, this p

250 ts of naringenin and sakuranetin may provide protection against specific pathogen profiles in differe

251 c steatosis, and 4) evidence for a sustained protection against steatosis induced by exercise.

252 enzymes are resistance proteins that provide protection against streptogramins(2), potent antibiotics

253 portant in mitochondrial quality control and protection against stress, we tested whether PACRG also

254 ntly, intratumoral vaccination also provides protection against subsequent active influenza virus lun

255 The plausibility that vaccine protection against symptomatic COVID-19 could be accompa

256 IgG also provides protection against systemic infection by E. coli.

257 on to study the mechanisms of failed genetic protection against T1D.

258 a A virus should offer long-term or lifelong protection against that strain, preventing reinfection.

259 virus strains reported to be able to induce protection against the ASFV Georgia isolate, and it is t

260 such genome modifications also provide broad protection against the CRISPR-Cas systems.

261 ve metabolic health in offspring and confers protection against the development of non-alcoholic fatt

262 host immunity remains the main mechanism of protection against the disease.

263 oduce evasive subclones, imparting transient protection against the effector T cells.

264 treated nontronite, conferring them a better protection against the external conditions.

265 MumR-regulated gene products are crucial for protection against the host immune response.

266 trigolactones, and ascorbic acid and provide protection against the oxidative stress-associated react

267 ubcutaneous (s.c.) immunization conferred no protection against the p.v. challenge.

268 nstrate that a significant proportion of the protection against the parasite is mediated by CD8(+) T

269 allenge simultaneously activates pre-emptive protection against the second impending challenge.

270 e TME- and the extracellular matrix-mediated protection against therapies.

271 43 and GPR109A are critical to SCFA-mediated protection against this condition.

272 g a single HF virus glycoprotein may provide protection against those filoviruses and LASV most commo

273 d on RNA interference was employed to induce protection against tomato mosaic virus (ToMV) infection

274 d opsonophagocytic killing by neutrophils or protection against toxin-mediated neutrophil lysis.

275 illus Calmette-Guerin (BCG) vaccine provides protection against tuberculosis (TB), and is thought to

276 orrelates and mechanisms of vaccine-elicited protection against tuberculosis.

277 Maximal protection against tumor development was observed when t

278 complete tumor clearance and subsequent full protection against tumor rechallenge in 33% of nanoformu

279 T. cruzi infection also seems to confer protection against tumorigenesis.

280 component of nearly all bacteria, providing protection against turgor pressure.

281 (95% confidence interval [CI], 67.1%-91.7%) protection against typical pharyngitis symptoms among ch

282 We estimated 77.1% (95% CI, 33.7%-96.3%) protection against typical symptoms among children acqui

283 tection of GAS emm types was associated with protection against typical symptoms when homologous stra

284 psule formulations successfully provide good protection against UV radiation.

285 Reduced-dose schedules may confer lower protection against vaccine-serotype carriage during and

286 ne-targeted pneumococcal serotypes resembles protection against vaccine-serotype invasive pneumococca

287 immunocompromised mice, induces robust host protection against vector sand fly challenge and because

288 and remains insecticidal, thereby providing protection against vector-borne diseases through prevent

289 ells demonstrate enhanced ISG expression and protection against vesicular stomatitis Indiana virus in

290 nd SIV vaccine candidates have shown partial protection against viral challenges in rhesus macaques.

291 Cytotoxic CD8(+) T cells are key for immune protection against viral infections.

292 CD8 T cell responses that are essential for protection against viral persistence.

293 n in LdCen(-/-) -immunized mice and impaired protection against virulent challenge.

294 K cells provide immune surveillance and host protection against viruses and tumors through their cyto

295 environmental ethanol altered the pattern of protection against wasp strains.

296 91,000/km(2) Wetlands confer relatively more protection against weaker storms and in states with weak

297 results support a major role for SXR/PXR in protection against xenobiotic-induced oxidative stress b

298 However, both vectors conferred protection against ZIKV infection in a lethal challenge

299 ccines expressing NS1, alone, confer partial protection against ZIKV infection in both immunocompeten

300 Complete protection against ZIKV infection was achieved with the

301 l immune responses but provided only partial protection against ZIKV viremia in BALB/c mice.