ライフサイエンスコーパス: protective

1 at induction of MCUb protein in the heart is protective.

2 lowing HI, but ethanol vehicle was partially protective.

3 -Mas receptor pathways have been shown to be protective.

4 Displacement of the protective 2-dimensional lattice formed by annexin V on

5 We estimated that PrEP was highly protective (85%-96% efficacy across regimens and sites)

6 Our results suggest that the ability of protective Abs elicited with one Salmonella serovar to e

7 Specifically, "coercive" emotions may prompt protective action by caregivers toward infant primates,

8 reater than primary infection despite that a protective adaptive response to UPEC infection was evide

9 V, has been demonstrated to be both safe and protective against AHF.

10 95% confidence interval [CI], 1.31-5.30) and protective against AKI (aOR, 0.08; 95% CI, 0.03-0.22).

11 t predictors of HR; component separation was protective against HR.

12 baseline levels of Porphyromonadaceae appear protective against infection, while carbapenem use is as

13 f the glycan-specific antibodies that can be protective against infectious agents exhibiting the same

14 ve intracellular bacterial infections but is protective against malarial toxin hemozoin.

15 tissue-specific cytokine responses that are protective against mortality during experimental sepsis.

16 Amiloride was protective against PAN-induced glomerular injury, reduci

17 Chronic statin usage is protective against post ERCP pancreatitis, and our findi

18 in an extracellular loop of SLC44A2 that is protective against venous thrombosis results in severely

19 They are a potential protective agent against neonatal sepsis.

20 Critically, the protective allele of the strongest AMD-associated CFH lo

21 e, gender, baseline BCVA and AMD subtype, A (protective) allele of C2-CFB-SKIV2L rs429608 was associa

22 ess simultaneously active (antimicrobial, UV-protective and antioxidant) and smart (temperature sensi

23 itis B virus (HBV) infection, antibodies are protective and correlate with recovery from infection.

24 Key questions are how protective and long-lasting a vaccine needs to be, and h

25 ditional immune functions that may have both protective and pathological consequences.

26 ase; and the functions of these cytokines in protective and pathological inflammation.

27 for developing novel approaches to modulate protective and pathological T cell responses in human di

28 host, the granulomatous response can be both protective and pathological.

29 These patterns likely distinguish acute (protective) and chronic (damaging) associated changes wi

30 protection, however, it is unclear how these protective antibodies function.

31 mplex with Fab fragments of these potent and protective antibodies reveal the details of a conserved

32 This role of the microbiota in eliciting protective antibodies to a specific neonatal pathogen re

33 es targeting rare B cells capable of broadly protective antibody responses are not hindered by promot

34 approximately 10 000 HCP aged <40 years had protective antibody.

35 andwich pair for the detection of an anthrax protective antigen (PA(83)).

36 and induces neutralizing antibodies against protective antigen (PA), the cell-binding component of a

37 or with an isogenic mutant deficient for the protective antigen.

38 vised ML classification to predict bacterial protective antigens (BPAgs).

39 nd inflammatory demyelination due to loss of protective antiviral host immunity.IMPORTANCE The curren

40 namic state of this renin-angiotensin system protective arm could influence long-term outcomes in pat

41 thin the materials they manufacture, such as protective armor and teeth.

42 residential greenness explained ~ 53% of the protective association between residential greenness and

43 (HR = 1.55; 95% CI, 1.06-2.28), whereas the protective association for ovarian and endometrial cance

44 This protective association of alpha-T was lost at higher gam

45 In this study, we did not identify a protective association of early childhood cow's milk vol

46 Fish intake contributed to this protective association.

47 on modifies T1D development, finding null or protective associations.

48 , maintains the opsonophagocytic killing and protective attributes of the antibody.

49 in atherosclerosis and suggest an initially protective autoimmune response against apoB with a progr

50 induce the alternative, and potentially reno-protective axis by enhancing Ang (1-7) production.

51 nsects is a chitinous structure that forms a protective barrier against oral pathogens and abrasive p

52 between the host and pathogen and provides a protective barrier against the immune response and antib

53 imicrobial peptides (AMPs), can disrupt this protective barrier by formation of leaky pores.

54 eal a potential mechanism for disrupting the protective barrier that K. pneumoniae uses to avoid the

55 ermatogenesis occurs in the testes, behind a protective barrier to ensure safeguarding of germline DN

56 d in porphyrin linkers of MOF sets the first protective barrier to inhibit the Fe agglomeration durin

57 tant goal, the approach necessarily breaks a protective barrier, temporarily, which plays a fundament

58 We propose that AHR is likely protective based on these data and inference from human

59 ask wearing correlated positively with other protective behaviors.

60 moval from the cell surface activates cancer-protective beta-arrestin-biased signaling (beta-arr-BS).

61 y secreting instructive cues and providing a protective brain barrier.

62 l, CD8(+) T cell, and antibody responses are protective, but uncoordinated responses frequently fail

63 MHC I expression in skeletal muscle is host protective by allowing for pathogen control while preven

64 , and that parental emotional support may be protective; (c) Adherence-suboptimal adherence was assoc

65 fore, testing this vaccine candidate for its protective capacity is warranted.IMPORTANCE The only HIV

66 This discovery indicates a protective capacity of the endogenous virus against the

67 Our studies suggest that Mcub is a protective cardiac inducible gene that reduces mitochond

68 ensus H1 as stem was shown to elicit broadly protective CD4(+) and CD8(+) T cell responses.

69 tion of dendritic cells and the induction of protective CD8(+) T cell responses.

70 ndings reveal unique molecular signatures of protective CD8(+) T cells and pave the way for T-cell-ba

71 A unique, protective cell envelope contributes to the broad drug r

72 CD8(+) memory T cells that form the basis of protective cellular immunity.

73 NG (STimulator of INterferon Genes) mediates protective cellular response to microbial infection and

74 e = 2.2 x 10(-56)), independently of the AMD-protective CFHR1-3 deletion, and even in those individua

75 Acylsugars, one class of protective compounds, are made in glandular trichomes of

76 dule provides a more widely exploited genome-protective control for the cell cycle, we show Aurora B

77 of parent zeolites with concentrated and non-protective coordination of Al species can facilitate pos

78 CA) neurons are essential for elicitation of protective counterregulatory responses (CRRs) to glucose

79 materials which stimulate the formation of a protective dentin bridge after insult are necessary to s

80 involving the autocrine remodeling of a drug-protective ECM.

81 ells, compared to other sources, has a clear protective effect against cases during the monsoon, when

82 The protective effect and good biocompatibility of Cu(5.4)O

83 This trial did not identify a significant protective effect and was not designed to evaluate sourc

84 functionally responsible for mediating this protective effect are unknown.

85 A protective effect from flavone copigmentation was observ

86 Laparoscopy has demonstrated a protective effect in colorectal surgery, but these effec

87 uestion whether CBD simultaneously induces a protective effect in GBM by upregulating autophagy.

88 ings suggest that lymphatics have an overall protective effect in lung injury and fibrosis and fit wi

89 vascular AMD, there is evidence suggesting a protective effect in slowing the progression of GA.

90 This protective effect is linked to the expansion of butyrate

91 The protective effect of DVF during L-TME on pelvic autonomi

92 the extracellular environment abolished the protective effect of heat shock.

93 There was also a protective effect of higher gamma' fibrinogen levels on

94 These data suggest a protective effect of increased ODC activity and elevated

95 The protective effect of MG on GBM was greater in the 3D mod

96 By demonstrating the protective effect of MN-siCas-3 in the challenging NHP m

97 pect to drug regimens, showing a significant protective effect of RAASi with a reduced risk of in-hos

98 Whilst no protective effect of rosuvastatin was seen, there was a

99 Little is known about the protective effect of spirituality on the association bet

100 However, studies have documented a protective effect of TTR against cellular toxicity of pa

101 s observation is compatible with a potential protective effect of type 1 CNV on the RPE and overlying

102 ention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfuncti

103 mity to a greener environment at birth has a protective effect on the development of allergic disease

104 ing number of siblings (P-value = .023), the protective effect reaching about 40% for children with 2

105 otected from arterial hypertension, and this protective effect was abrogated by IP antagonists.

106 ome and invertebrates in inducing an allergy-protective effect, as proposed by the hygiene hypothesis

107 mortality, and suggest that BCG could have a protective effect.

108 ed girls, HE for unvaccinated girls, and the protective effectiveness (PE) for all girls were estimat

109 vation, it would be arguable that diets with protective effects against cardiovascular disease exert

110 stically, we demonstrate that APP-103 exerts protective effects by specifically targeting the product

111 x in islet cells, and all measured beta-cell-protective effects correlated with this activity.

112 one 17beta-estradiol (E2) has shown vascular protective effects in lung tissue of brain death (BD) ma

113 l novel candidate mechanisms involved in the protective effects of EE against cocaine seeking, which

114 In this study, we examined the protective effects of Garcinia indica extract standardiz

115 ilitating emotional symptoms, as well as the protective effects of glucocorticoids against their deve

116 function with WD consumption, the remarkable protective effects of voluntary aerobic exercise, and th

117 MRE+BIO combination therapy had additive protective effects on DeltaGFR, glomerulosclerosis, podo

118 s (MCFAs) have in rodents been shown to have protective effects on glucose homeostasis during high-fa

119 y understood, and it remains unclear whether protective effects on hepatic metabolism are already see

120 These protective effects were mimicked by acetate, but not by

121 was associated with large but circumscribed protective effects.

122 le of inducing cellular immune responses and protective efficacy against intracellular pathogens.

123 pigs, metformin enhances immunogenicity and protective efficacy against M. tuberculosis challenge.

124 ssing PfLSA1 or PfLSAP2 was shown to improve protective efficacy compared to vaccination with each si

125 rculosis (M.tb.) challenge model to test the protective efficacy of BCG-disA-OE versus wild-type BCG

126 57BL/6 mice prior to challenge abrogated the protective efficacy of GCP-rCpa1 vaccine.

127 ORTANCE The only HIV vaccine trial for which protective efficacy was detected correlated this efficac

128 livery of nucleic acid immunogens to improve protective efficacy.

129 monstrated high levels of pre- and post-CHMI protective efficacy.

130 (NPs) as a result of thermal annealing under protective environment.

131 is studies revealed a complex landscape with protective epitopes clustering in at least 6-7 antigenic

132 promising prophylactic antibodies and define protective epitopes that can be used in rational vaccine

133 he humoral response away from targeting more protective epitopes.

134 medical Hardware (FOSH) as well as personal protective equipment (PPE) currently being developed and

135 use, and 43 programs reported that personal protective equipment (PPE) was suboptimal.

136 ariable analyses, using any form of personal protective equipment (PPE) when interacting with a confi

137 hair of health care workers wearing personal protective equipment after intubating patient manikins u

138 should be used in conjunction with personal protective equipment including masks, goggles, and glove

139 sting of environmental surfaces and personal protective equipment surrounding 3 COVID-19 patients in

140 h care provider exposure and use of personal protective equipment.

141 plasmic reticulum (ER) stress, (2) decreased protective ER chaperones, and (3) greater cell death and

142 Human milk (HM) could be considered as a protective factor against FA, but its mechanisms remain

143 scriptional reprogramming and a novel hepato-protective factor.

144 nment exposure to livestock is the strongest protective factor.

145 ing) and seven self-reported INSPIRE-aligned protective factors (positive parenting, parental monitor

146 , risk factors include cesarian section, and protective factors include consumption of fermented milk

147 EMA mediated the protective farm effect by 19%.

148 vement in DD grade/grade 1 DD at 30 days was protective for 1-year CV death/rehospitalizations (hazar

149 Replication, detoxification, and a cancer-protective form of regulated cell death termed ferroptos

150 -lived effector cells [LLEC]) display robust protective function during acute rechallenge with bacter

151 Here we demonstrate a protective function for the IL-33-ST2 axis in bronchial

152 ogenous factor causes emphysema; its pivotal protective function is suggested by its ability to overc

153 rate that TDP-43 is required to maintain the protective functions of astrocytes relevant to the devel

154 Aside from integrating the protective functions of IgA, these hitherto neglected mu

155 ey are bound by proteins with inhibitory and protective functions.

156 the performance of the materials as athletic protective gear is demonstrated.

157 In persons with the protective genetic alleles of complement factor H (CFH),

158 to A. ervi: one line infected with a highly protective H. defensa strain, one infected with a modera

159 ting limited human group I coronavirus cross protective herd immunity.

160 The presumably protective HFD-induced hepatic expression of the metabol

161 in complex with a pan-H7, non-neutralizing, protective human Ab.

162 While the relationship of protective human leukocyte antigen (HLA) class I alleles

163 Triple-knockout (TKO) pigs (with added protective human transgenes) are likely to be optimal so

164 trong, Th1-skewed T cell responses can drive protective humoral and cell-mediated immune responses(2)

165 subjects immunized for measles do not show a protective IgG titer in the 10 years after vaccination.

166 e investigated the mechanisms underlying the protective immune response in mice.

167 tion against their binding domains elicits a protective immune response.

168 new method to broaden and potentially extend protective immune responses against Ebola viruses.

169 Furthermore, protective immune responses are heterogeneous, with no s

170 it with the ALVAC vector could increase the protective immune responses.

171 disease pathology and increased Mtb-specific protective immune responses.

172 tes with downstream CD8(+) T cell memory and protective immunity against infectious challenge.

173 ng CD107(ab+) CD4(+) T cells associated with protective immunity against ocular herpes infection and

174 ponse in the cornea that was associated with protective immunity against ocular herpes.

175 whether infection with SARS-CoV-2 results in protective immunity against reexposure.

176 tative of most Covid-19 patients, long-lived protective immunity against SARS-CoV-2 after primary inf

177 ns as a candidate vectored vaccine to elicit protective immunity against SARS-CoV-2.

178 at IL-25 signaling subverts the induction of protective immunity and amplifies the type 2 immune resp

179 However, to date, studies on protective immunity have been performed only in animal m

180 s concerning the prevalence and longevity of protective immunity have left vulnerable communities fea

181 resident memory (Trm) CD8(+) T cells mediate protective immunity in barrier tissues, but the cues pro

182 strongly attenuated in virulence and induced protective immunity in mice.

183 of the GIT is not necessary for induction of protective immunity in the FRT, a finding that is import

184 erstanding of the mechanisms involved in the protective immunity to alpha-Gal and discuss the possibi

185 e in transmission, risks for severe disease, protective immunity, as well as novel therapies and vacc

186 doxically exert antitumor activity and prime protective immunity, the pathways driving this phenotype

187 fication to reduce NLRC4 activation enhances protective immunity, which could have important implicat

188 igens can be sufficient for parasite-induced protective immunity.

189 inst this protein region is not essential to protective immunity.

190 ific role for P2X5 as a critical mediator of protective immunity.

191 s, two immunodominant antigens implicated in protective immunity.

192 h we urgently need a better understanding of protective immunity.

193 is study establishes a new minimal length of protective immunity.

194 nk inductive and effector phases to generate protective immunity.

195 hat supports tissue homeostasis and provides protective immunity.

196 h enables the glucose-dependent secretion of protective immunomodulatory factor interleukin-10.

197 eting the RSV G central conserved domain are protective in both prophylactic and postinfection animal

198 Although BAT has been implicated to be protective in cardiovascular disease, to this point ther

199 lity, TIMP3 overexpression proved to be less protective in cartilage destruction than [-1A]TIMP3 at l

200 he later stage of the study Universal PPE is protective in procedural settings.

201 These antibodies are protective in prophylaxis against seasonal H1N1 viruses

202 is anthrax vaccine adsorbed (AVA), which is protective in several animal models and induces neutrali

203 ages of M. tuberculosis infection, we showed protective in vitro and in vivo efficacy of polyclonal I

204 by preventing virus entry and spread and is protective in vivo in mouse models.

205 design and implementation of a more broadly protective influenza vaccine.

206 X) pathways, participate in the induction of protective innate immune responses during invasive asper

207 A protective interphase layer will be formed outside templ

208 nefits, risks, burden, costs) of the various protective interventions, in particular among real-world

209 a suggest that increasingly punitive and non-protective laws are associated with prevalent HIV infect

210 o construct an electrochemically recoverable protective layer of polysulfides using an electrolyte ad

211 establishes the reliability of carbon paint protective layers and provides a procedure for discrimin

212 d ac techniques, revealing that carbon paint protective layers provide a solution to three well-known

213 s the direct assessment of the efficiency of protective layers toward deterioration of hybrid organic

214 Protective mAbs map to exposed epitopes in the wing doma

215 S,S, a minimal repeat-only, epitope-focused, protective, malaria vaccine was designed.

216 This protective measure alone significantly reduced the numbe

217 red fluid dynamic mechanisms of seed flight, protective measures against fire, and release mechanisms

218 have implications for the need of continued protective measures and for vaccines for persons previou

219 he measures taken to reorganize the work and protective measures, as well as the repercussions of the

220 Until now, however, the protective mechanism has been unknown.

221 ion, CD163-expressing macrophages serve as a protective mechanism to prevent the deleterious effects

222 that low connectivity and plasticity provide protective mechanisms against network fracture that can

223 g the reproductive period of life due to the protective mechanisms of oxidative shielding and reveale

224 xplain this phenomenon as resulting from two protective mechanisms: defence of staff's professional i

225 t coexist in our bodies and are essential in protective, metabolic, and physiologic functions of huma

226 lic reconfiguration towards the synthesis of protective metabolites of those fruits can possibly conf

227 Protective MHC class I-dependent immune responses requir

228 ecently published research letter "Is asthma protective of COVID-19?" by Carli et al.(1) with great i

229 dvisory for drinking water may or may not be protective of vegetable exposures to these contaminants.

230 estions remain about whether autophagy has a protective or a pathological role in kidney fibrosis, an

231 produce trichomes-epidermal hairs that have protective or more specialized roles.

232 s governing SARS-CoV-2 pathogenesis, and the protective or pathogenic immune responses related to dis

233 The contribution of CD4(+) T cells to protective or pathogenic immune responses to SARS-CoV-2

234 Furthermore, whether NLRP3 plays a protective or pathogenic role during Leishmania spp. inf

235 B cells can assume protective or pathogenic roles in immune-mediated diseas

236 Whether microglia are protective or pathologic is context dependent; the outco

237 tions are often interpreted in the light of 'protective' or 'detrimental' CD8(+) T cell responses whi

238 those that lead to cellular accumulation of protective organic osmolytes.

239 al properties of ultrathin a-C films used as protective overcoats.

240 al for brain health, and endogenous vascular protective pathways may provide therapeutic targets for

241 hich are used in this work as models for the protective phospholipid layers of the gastric mucosa.

242 major effect on the human genome, with many protective polymorphisms-such as the sickle-cell trait-h

243 ecific monoclonal antibodies (M2e-MAbs) show protective potential against influenza A, however, they

244 specific inhibitor, AZ505, led to increased protective proinflammatory response and inhibited amasti

245 to neutralizing IgG antibody responses in a protective range, multifunctional CD8(+) and CD4(+) T ce

246 We have previously shown that protective respiratory reflexes to locally released bact

247 6.8% (21/37; 95% CI, 39.5%-72.9%) achieved a protective response at 1 month and 43.3% (13/30; 95% CI,

248 ated during maintenance (group 1) achieved a protective response at 1 month postvaccination and none

249 se at 1 month postvaccination and none had a protective response at 12 months.

250 Cell stress often triggers inflammation as a protective response to tissue damage or infection.

251 inant migration to the subretinal space as a protective response, whereas the abundant presence ofmon

252 thus offering a higher coverage and greater protective response.

253 pre-existing flavivirus immunity and elicit protective responses against both ZIKV and DENV.

254 Ablation of vagal P2RY1 neurons eliminates protective responses to laryngeal water and acid challen

255 to tissue damage through the upregulation of protective responses which restore tissue structure and

256 us inhibitor of Nrf2 signaling-dampens these protective responses.

257 n direct competition for binding sites among protective RNA-binding proteins and decay factors, PTBP1

258 vidence supports that antibodies also have a protective role against TB.

259 r from resolved, with some studies showing a protective role and others showing a pathogenic role.

260 These data suggest a hepato-protective role for CC to limit ROS and cellular TG accu

261 r, these studies demonstrate that there is a protective role for central memory CD8(+) T cells in aut

262 ignaling, we demonstrate a critical vascular protective role for endothelial S1P(1) in the mouse brai

263 This finding suggests a protective role for mucosal antibody-mediated immunity i

264 n.Conclusions: Here, we demonstrate a unique protective role for pulmonary endothelial HIF-2alpha and

265 This study implies a protective role for VD sufficiency throughout pregnancy,

266 vidence that eIF2alpha phosphorylation has a protective role in CMT1B Schwann cells by limiting ERK/c

267 essary for melanin production, thus having a protective role in the UVA-induced skin response.

268 by serving as a decoy receptor, and plays a protective role in ZIKV-mediated brain injuries.

269 ain actively transcribed genes and that this protective role is most prominent at heterochromatin isl

270 that anticoagulant therapy might dampen the protective role of immunothrombosis.

271 The current study does support the protective role of influenza vaccination on CVDs events.

272 al role of periostin in CKD, we discovered a protective role of periostin in AKI.

273 termine whether perforin-2 plays a similarly protective role.

274 lational tools to make development of axonal protective, SARM1 inhibitors a viable approach to treat

275 Studies on the economic valuation of this protective service provided by wetland ecosystems are, h

276 dministration of 5-HD and 8-SPT blocking key protective signaling routes abrogated the salutary effec

277 duction of antibody responses and a putative protective signature.

278 inkles of the graphene film endow the robust protective skin with high stretchability.

279 fensa strain, one infected with a moderately protective strain and one without any facultative symbio

280 region in vaccinated volunteers, potentially protective subdominant responses to PfCSP C-terminal reg

281 iable frequencies of aphid clones containing protective symbionts; these patterns were consistent wit

282 ication of toxic metabolites, constituting a protective system against reactive carbonyl compounds in

283 nd that BHLHE40 is required in T cells for a protective T(H)2 cell response in mice infected with the

284 a1 is a key placental IFN that appeared less protective than IFN-alpha, suggesting a potential weakne

285 single-dose vaccination with JENVAC induces protective titers that persist up to 1 year.

286 central corneal thinning (P = .002), and was protective to the endothelium (P = .008).

287 of NMP is to provide an environment that is protective to the organ, ensures optimal oxygen delivery

288 (IL1) response, respectively, which confers protective trained immunity against Mtb.

289 sses myelopoiesis and impairs development of protective trained immunity to Mtb.

290 This protective trend was reiterated in asthma or recurrent w

291 ogy the authors identify SPy_2191 as a cross-protective vaccine candidate.

292 immune response that would yield pronounced protective vaccine efficacy.

293 Broadly protective vaccines against known and preemergent human

294 er virus infection include both a paucity of protective vaccines as well as the early identification

295 To develop better, more broadly protective vaccines, a more thorough understanding is ne

296 globally devastating diseases without fully protective vaccines, particularly human immunodeficiency

297 Protective ventilation strategies for the injured lung c

298 pecific IgA and IgG isotypes are potentially protective within the humoral compartment.

299 new experimentally defined minimal length of protective ZIKV immunity.

300 new experimentally defined minimal length of protective ZIKV immunity.IMPORTANCE ZIKV emerged as a ve