ライフサイエンスコーパス: protein aggregation

1 ed as a surrogate marker of non-amyloid-beta protein aggregation.

2 ture in neurodegenerative diseases involving protein aggregation.

3 e complex formation but higher propensity of protein aggregation.

4 to- or nucleoplasm and can regulate aberrant protein aggregation.

5 in protection against neurodegeneration and protein aggregation.

6 f rational therapies to control pathological protein aggregation.

7 lmark of neurodegenerative disease caused by protein aggregation.

8 erous cellular stresses, including increased protein aggregation.

9 red proteins often play an important role in protein aggregation.

10 nd predisposes these methods for spontaneous protein aggregation.

11 aggregation pathway to further delay client protein aggregation.

12 g of TDP-43 to specific RNA can compete with protein aggregation.

13 hin the first 10 min after the initiation of protein aggregation.

14 posttranslational modification O-GlcNAc and protein aggregation.

15 ement common or distinct mechanisms to delay protein aggregation.

16 uffer concentration to 10 mM, also prevented protein aggregation.

17 used in protein evolution to limit unwanted protein aggregation.

18 urodegeneration occurs in the absence of FUS protein aggregation.

19 fied the protein MOAG-2/LIR-3 as a driver of protein aggregation.

20 ding with consequent aberrant intermolecular protein aggregation.

21 led to straightforward biophysical models of protein aggregation.

22 ain self-assembled chromophore formed due to protein aggregation.

23 ch are efficient inhibitors of non-fibrillar protein aggregation.

24 wever, is their ability to cause substantial protein aggregation.

25 ess under stress by reversing stress-induced protein aggregation.

26 synthetic genetic tool to sense and control protein aggregation.

27 ssect the complicated misfolding pathways of protein aggregation.

28 ar species formed during the early stages of protein aggregation.

29 icle fission and fusion, and shape-dependent protein aggregation.

30 allmarks of proteostasis collapse, including protein aggregation.

31 gregation activity against bile salt-induced protein aggregation.

32 oteins probably by lowering the threshold of protein aggregation.

33 te in maintaining proteostasis by preventing protein aggregation.

34 the understanding of the molecular onset of protein aggregation.

35 proteins display prion-like transmission of protein aggregation.

36 ults in cytotoxicity associated with massive protein aggregation.

37 lded substrate proteins and prevent cellular protein aggregation.

38 ts in aberrant tubulin morphology suggesting protein aggregation.

39 ffering insight into disease-related in vivo protein aggregation.

40 gy for controlling and understanding amyloid protein aggregation.

41 n species or acting as chaperones to prevent protein aggregation.

42 ins, their relation to RNA and their role in protein aggregation.

43 g protein solubility and preventing aberrant protein aggregation.

44 tand the underlying mechanism(s) of membrane protein aggregation.

45 tomic level origins as well as mechanisms of protein aggregation.

46 serves as a model of neurodegeneration with protein aggregation.

47 productively, while minimizing the danger of protein aggregation.

48 a key determinant of its ability to promote protein aggregation.

49 that respond to cellular stresses to combat protein aggregation.

50 We then demonstrate that age-dependent protein aggregation accelerates the functional decline o

51 Within the mitochondrial matrix, protein aggregation activates the mitochondrial unfolded

52 We show that the device induces protein aggregation after exposure to an extensional flo

53 To prevent or regulate protein aggregation, all cells contain an extensive prot

54 system, innate immunity, LPS scavenging, and protein aggregation/amyloid formation.

55 a 'silent presence' or the 'stone guest' of protein aggregation, an important component of the proce

56 diction of a model integrating autocatalytic protein aggregation and a minimal Start network, enforce

57 Hsp70 is a protein chaperone that prevents protein aggregation and aids protein folding by binding

58 le of perturbations in TDP-43 homeostasis in protein aggregation and ALS-FTD pathogenesis.

59 g proteome and are responsible for increased protein aggregation and altered cell proteostasis.

60 y of ALS remains poorly understood, abnormal protein aggregation and altered proteostasis are common

61 Protein aggregation and axonal transport deficits have b

62 hydrochloride (ArgHCl) was used to suppress protein aggregation and carbohydrates (i.e., mannitol, s

63 tal dopamine dysfunction precedes detectable protein aggregation and cell death in the development of

64 cells and rendered animals more resistant to protein aggregation and chronic ER stress.

65 lipid transport efficiency or in AD-related protein aggregation and clearance.

66 In vivo, CCPG1 protects against ER luminal protein aggregation and consequent unfolded protein resp

67 tion modulated by Ube2v1 expression enhanced protein aggregation and contributed to Ube2v1's function

68 Using protein aggregation and cytotoxicity assays, we found th

69 itate aberrant phase transitions and lead to protein aggregation and disease.

70 ein oligomers present at different stages of protein aggregation and establish a relationship between

71 tein, is one mechanism proposed to stimulate protein aggregation and facilitate disease pathogenesis.

72 he Arctic mutant variant leads to aggressive protein aggregation and increased intracellular toxicity

73 Here, we combine kinetic theory of protein aggregation and liquid-liquid phase separation t

74 ctly in protein formulation buffer, reducing protein aggregation and liver uptake.

75 ts and aerosolization stresses, resulting in protein aggregation and loss of activity, were overcome

76 sociated with myofibrils) pointed to evident protein aggregation and loss of functionality when phyti

77 y act, at least in part, by limiting in vivo protein aggregation and loss of membrane integrity.

78 the roles of different lipids in pathogenic protein aggregation and membrane disruption, remain elus

79 h model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress.

80 As a causal relationship between protein aggregation and neurodegeneration remains elusiv

81 sed Abeta-induced metabolic defects, reduced protein aggregation and normalized lifespan of GRU102.

82 n of the link between the molecular basis of protein aggregation and optimal strategies for inhibitin

83 ons in analogous metabolic processes such as protein aggregation and oxidative stress, both of which

84 ment by macromolecules is thought to promote protein aggregation and phase separation.

85 nucleic acids act as potential cofactors for protein aggregation and prionogenesis.

86 s the proposed adjuvant role of RNA in prion protein aggregation and propagation, and thus advocates

87 erexpression of certain chaperones abrogates protein aggregation and protects a UPR mutant against ER

88 te protoporphyria with consequent hepatocyte protein aggregation and proteotoxic multiorganelle alter

89 lized protein disaggregases to reverse toxic protein aggregation and restore protein functionality.

90 sed by heating at 80 degrees C, which caused protein aggregation and solution turbidity.

91 omplex proteostasis network actively combats protein aggregation and that such an efficient system ca

92 rexpression of active HYPE similarly induced protein aggregation and the HSF1-dependent heat shock re

93 Understanding the fundamentals of prion protein aggregation and the molecular architecture of Pr

94 ar and cellular factors that protect against protein aggregation and those that promote it.

95 The mechanisms underpinning protein aggregation and toxicity are introduced, and opp

96 local translation and prevents premature ATI protein aggregation and trapping of virions within the f

97 ons in proteostasis characterized by diffuse protein aggregation and ubiquitination.

98 type D1 (LGMDD1), which is characterized by protein aggregation and vacuolar myopathology.

99 dox, highlighting the roles of biochemistry, protein aggregation, and disruption of cellular microstr

100 ng, genomic instability, epigenetic changes, protein aggregation, and down-regulation of quality cont

101 with physicists to understand the process of protein aggregation; and finally, his later career in wh

102 rrest act synergistically to kill cells, and protein aggregation appears to occur more rapidly in pro

103 Protein aggregation appears to originate from partially

104 Cellular processes accompanying protein aggregation are diverse and entangled, making it

105 ishomeostasis, aberrant protein folding, and protein aggregation are indeed involved in several disea

106 cases of DNA both increasing and preventing protein aggregation are observed to stem from this enhan

107 Tau protein aggregations are a hallmark of amyloid-associate

108 l feature of the aneuploid state and reveals protein aggregation as a form of dosage compensation to

109 r using residue-specific or process-specific protein aggregation as a target.

110 Intraneuronal protein aggregation as a trigger for inflammation and ne

111 lude evidence of Alzheimer's disease-related protein aggregation as an underlying mechanism of age-re

112 ion in zebrafish liver causes multiorganelle protein aggregation as determined by mass spectrometry a

113 eins constitute central determinants both in protein aggregation as well as in amyloid cytotoxicity.

114 ng systems, such as protecting cells against protein aggregation, assisting protein folding, remodeli

115 old therapeutic potential to protect against protein aggregation-associated cellular defects.

116 ired to survive proteotoxic stress caused by protein aggregation at high temperatures.

117 Prions are a prototypic model to study protein aggregation biology and therapeutic development.

118 moiety, acts as a selective inhibitor of tau protein aggregation both in vitro and in transgenic mous

119 e that protects cells against stress-induced protein aggregation, but also as a robust modifier of am

120 Such diseases are associated with protein aggregation, but the contribution of aggregates

121 nvironment of liquid droplets could modulate protein aggregation by altering kinetics of protein self

122 gation and to provide a new strategy to tune protein aggregation by modulating the exposure of aggreg

123 Since peptide and protein aggregation can obscure specific binding, and si

124 the literature suggests that RNA-RNA binding protein aggregations can disturb neuronal homeostasis an

125 gation and a minimal Start network, enforced protein aggregation causes a severe reduction in lifespa

126 es previously linked to autophagy, including protein aggregation, cell survival, bacterial replicatio

127 cessing, incorrect disulfide-bond formation, protein aggregation, changes in gene expression, and ple

128 he hypothesis that neuroinflammation and tau protein aggregation colocalize macroscopically, and corr

129 novel disease-relevant phenotypes, including protein aggregation, compromised neuritic outgrowth, and

130 ns unclear how mitochondrial dysfunction and protein aggregation could be related.

131 In nematodes, osmotic stress induces massive protein aggregation coupled with unfolded protein respon

132 Immunoglobulin light-chain amyloidosis is a protein aggregation disease that leads to proteinaceous

133 egation in vitro, the cause and mechanism of protein-aggregation disease remain poorly understood.

134 idence that the toxic oligomeric entities in protein aggregation diseases contain antiparallel, out-o

135 The growing importance of protein aggregation diseases requires the development of

136 ediction, which is used to create models for protein aggregation diseases such as Alzheimer's Disease

137 However, with the rising incidence of protein aggregation diseases, it is now important to und

138 their metastability may underlie devastating protein aggregation diseases.

139 in ER function associated with degenerative protein aggregation diseases.

140 ssion of small amyloids in neurodegenerative protein aggregation diseases.

141 fects of proteasome dysfunction in aging and protein aggregation disorders, or increase effectiveness

142 Analogous to protein aggregation disorders, our results suggest that

143 rovides a potential therapeutic strategy for protein aggregation disorders.

144 e can increase amyloidogenesis and aggravate protein aggregation disorders.

145 perties known for their mechanistic roles in protein aggregation do not correlate well with the aggre

146 interactions and efficiency of drugs against protein aggregation drivers.

147 alpha- and gamma-gliadins in DDGS indicated protein aggregation during the drum drying processing st

148 can act as molecular chaperones that prevent protein aggregation, even under extreme conditions.

149 The pH shift resulted in protein aggregation, evident from the pronounced increas

150 ative disease is focal onset of pathological protein aggregation, followed by progressive spread of p

151 se bonds are ultimately responsible for wine protein aggregation following a nucleation-growth kineti

152 neurodegenerative proteinopathies involving protein aggregation; for example, in the accumulation of

153 attenuation of protein translation, massive protein aggregation, growth arrest, and lethality.

154 More recently, widespread protein aggregation has been described during normal agi

155 Protein aggregation has been implicated in many medical

156 racterization of the nature of age-dependent protein aggregation has been lacking.

157 More recently, such abnormal protein aggregation has been reported to spread from cel

158 Although the inhibition of amyloid protein aggregation has been well-studied, the disaggreg

159 However, the effect of glycation on protein aggregation has not been fully investigated.

160 bind sleep, aging, glymphatic clearance, and protein aggregation have shed new light on the pathogene

161 ck proteins (sHsps), normally act to prevent protein aggregation; however, it remains to be determine

162 n depends on: (i) the specific mechanisms of protein aggregation, (ii) the hierarchical structure of

163 ic Cas9 mice alleviated CryAB(R120G)-induced protein aggregation, improved cardiac function, and prol

164 Small heat shock proteins (sHSPs) delay protein aggregation in an ATP-independent manner by inte

165 stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells.

166 Collectively, our data implicate global protein aggregation in apoptotic cells as a mechanism th

167 s have shown that nucleic acids can nucleate protein aggregation in disease-related proteins, but in

168 se association between neuroinflammation and protein aggregation in frontotemporal dementia.

169 mechanisms that limit FVIII secretion and ER protein aggregation in general and have implication for

170 simple molecular-level framework to describe protein aggregation in general and to visualize the kine

171 es an auxiliary role of the nucleic acids in protein aggregation in general.

172 of an investigator interested in the role of protein aggregation in human disease and as a physician

173 quo of current imaging methods to visualize protein aggregation in live cells but also can be genera

174 ch as sodium 4-phenylbutyrate (PBA), reduces protein aggregation in neural stem cells in vitro and in

175 with the central molecular mechanisms of CNS protein aggregation in neurodegenerative disorders.

176 cytokines, these exosomes further increased protein aggregation in neurons.

177 o patterns of neuroinflammation and abnormal protein aggregation in seven cases of familial frontotem

178 on's disease, are characterized by increased protein aggregation in the brain, progressive neuronal l

179 seeds already exist during the lag phase of protein aggregation in the brain.

180 ruit protein chaperones to sites of presumed protein aggregation in the budding yeast Saccharomyces c

181 Protein aggregation in the mitochondria is increasingly

182 dismutase 1 (SOD1) have been linked to toxic protein aggregation in the neurodegenerative disease amy

183 Protein aggregation in the nuclear and cytoplasmic fract

184 to study the spatial control of irreversible protein aggregation in the presence of liquid compartmen

185 d by microglia are fully capable of inducing protein aggregation in the recipient neurons.

186 led, non-pathological, physiological role of protein aggregation in the regulation of a major metabol

187 Although R-DPRs induce widespread protein aggregation in this in vitro system, transport d

188 at BBR exhibited chaperone activity, reduced protein aggregation in vitro and alleviated tunicamycin-

189 Hsp110/Sse1 also can prevent protein aggregation in vitro via its substrate-binding d

190 gress in uncovering the molecular details of protein aggregation in vitro, the cause and mechanism of

191 Consistent with this prediction, protein aggregation in yeast and worms was observed to i

192 isincorporation is toxic to cells and causes protein aggregation in yeast.

193 selection to regulate collapse and minimize protein aggregation, in addition to their roles in stabi

194 describe a mechanism for intracellular toxic protein aggregation induced by an unusual mutation event

195 yield pathophysiologic mechanisms, including protein aggregation, inflammation, metabolic disruption,

196 Protein aggregation is a common biological phenomenon, o

197 Protein aggregation is a complex physiological process,

198 Protein aggregation is a complex process resulting in th

199 Protein aggregation is a hallmark of many diseases but a

200 Our findings suggest that protein aggregation is a major driver of aging and cell

201 Protein aggregation is a major unsolved problem in bioch

202 However, protein aggregation is a reversible process but disaggre

203 Protein aggregation is a widely studied phenomenon that

204 Together, these data suggest that protein aggregation is an early aging-associated differe

205 dicate that widespread amorphous and amyloid protein aggregation is an unanticipated outcome of such

206 Protein aggregation is associated with age-related neuro

207 Protein aggregation is associated with neurodegenerative

208 Protein aggregation is broadly important in diseases and

209 Aberrant protein aggregation is controlled by various chaperones,

210 tanding the underlying mechanisms of cardiac protein aggregation is critical for seeking therapeutic

211 Protein aggregation is determined by short (5-15 amino a

212 Intercellular propagation of protein aggregation is emerging as a key mechanism in th

213 Aberrant protein aggregation is inducible in rodents and primates

214 Protein aggregation is involved in many diseases.

215 ts are either degraded or aggregate and that protein aggregation is nearly as effective as protein de

216 rong support in favor of the hypothesis that protein aggregation is not a primary cause of cytotoxici

217 Abnormal protein aggregation is observed in an expanding number o

218 Protein aggregation is the abnormal association of prote

219 Protein aggregation is the hallmark of neurodegeneration

220 Protein aggregation is the underlying cause of many dise

221 To address this key problem, we combine here protein aggregation kinetics and control theory to deter

222 In conclusion, the protein aggregation kinetics are impacted by local facto

223 nce and structure-based properties determine protein aggregation kinetics in each class.

224 and how I138M, I139M, and S143N affect prion protein aggregation kinetics.

225 rotects invertebrates and mammals from toxic protein aggregation linked to neurodegeneration and from

226 sents a critical link to the pathogenesis of protein aggregation-linked diseases.

227 To protect against undesired protein aggregation, living cells maintain a population

228 blems, including mapping epitopes, following protein aggregation, locating small molecule binding, me

229 from our analysis is the dual role of RNA in protein aggregation, making RNA, that has been considere

230 that the factors and components that control protein aggregation may be evolutionary conserved.

231 Drug-induced proteome stress that involves protein aggregation may cause adverse effects and underm

232 s uncover a translational stalling-dependent protein aggregation mechanism, and provide evidence that

233 applicability of this method to investigate protein aggregation mechanisms important to both industr

234 in the huntingtin protein (Htt) that promote protein aggregation, neurodegeneration, and death.

235 oung mice, which recapitulated the increased protein aggregation observed in old mice.

236 differences in translation, solubility, and protein aggregation of DPRs between c9ALS/FTD and SCA36.

237 An increased protein aggregation on the surface of fat globules follo

238 Protein aggregation, once believed to be a harbinger and

239 protein homoeostasis resulting from abnormal protein aggregation or a defect in the protein clearance

240 eterogeneities in the membrane either due to protein aggregation or due to membrane composition.

241 gressive motor dysfunction in the absence of protein aggregation or significant motoneuron loss, ques

242 says, we demonstrate that after heat-induced protein aggregation, OTUB1 reacts strongly with both ant

243 nction and also dysfunction, for example, in protein aggregation pathologies.

244 possibility of routine noninvasive study of protein aggregation phenomena.

245 ApoE protein aggregation plays a central role in AD pathology

246 Protein aggregation plays a critical role in the pathoge

247 lytic action of fibrillar species during the protein aggregation process in driving deleterious biolo

248 nging because of the great complexity of the protein aggregation process itself.

249 automated real-time ex situ tracking of the protein aggregation process.

250 able technology to study and control diverse protein aggregation processes in cells.

251 of the protein native state determines both protein aggregation propensity and structural peculiarit

252 er, stress conditions shift the criteria for protein aggregation propensity.

253 hibition, these compounds induce nonspecific protein aggregation, providing molecular explanation for

254 utomated system for tracking the progress of protein aggregation reactions without the presence of ma

255 recapitulate features of human ALS (ie, SOD1 protein aggregation, reduced cell viability, perturbatio

256 ysical factors in driving this transition in protein aggregation-related diseases and open a new rout

257 ded to tackle the molecular basis of all the protein-aggregation-related diseases.

258 echanisms by which these compartments affect protein aggregation remain unknown.

259 how virus-induced aberrant proteostasis and protein aggregation resemble the cellular pathology of s

260 Our results suggest that aberrant CAT-tailed protein aggregation results from a defect in Cdc48 recru

261 es of macroautophagy, including disorganized protein aggregations (sequestosomes), sequestosomes flan

262 remains approximately constant during aging, protein aggregation sharply increases between days 6 and

263 results identify osmotic stress as a potent protein aggregation stimuli in mammalian brain and furth

264 and controlling disorders that are linked to protein aggregation, such as Alzheimer's and Parkinson's

265 ence intensity is observed only with ordered protein aggregation, such as amyloid fibril formation, a

266 a number of neurological disorders caused by protein aggregation, such as amyotrophic lateral scleros

267 r chaperone ability that prevented amorphous protein aggregation, suggesting a potential role for N-t

268 siological assembly and prevent pathological protein aggregation, suggesting a potential treatment pa

269 new recurrent p.Leu254Gln mutation leads to protein aggregation, suggesting abnormal folding.

270 Our results indicate that the protein aggregation systems of cooked hams and emulsion

271 romising label-free tool to explore in-vitro protein aggregation that takes place during the progress

272 Deficits in the ALP result in protein aggregation, the generation of toxic protein spe

273 Although polyglutamine expansion accelerates protein aggregation, the misfolding process is frequentl

274 an important model system for understanding protein aggregation, the new peptide may be an important

275 e of diseases linked to either aneuploidy or protein aggregation, this study could serve as a springb

276 on networks, the analysis of kinetic data of protein aggregation to obtain the underlying mechanisms

277 suggested to possess a great value to tackle protein aggregation toxicity and neurodegenerative disea

278 nd life and confer protection to age-related protein-aggregation toxicity are activated early in adul

279 In summary, we present a protein-aggregation-triggering mechanism that should be

280 without causing damage to mucosa or inducing protein aggregation under physiological conditions.

281 Aberrant protein aggregation underlies a variety of age-related n

282 ropose, creates a permissive environment for protein aggregation, unresolved ER stress, and chronic i

283 to determine optimal protocols that prevent protein aggregation via specific reaction pathways.

284 nce of either buffer salt crystallization or protein aggregation was observed.

285 of the divalent metal manganese (Mn(2+)) in protein aggregation, we characterized its effect on alph

286 rther investigate the role of HspX in native protein aggregation, we performed semi-quantitative mass

287 ng data with a simple computational model of protein aggregation, we show that the establishment of a

288 llular polyamines, which are associated with protein aggregation, were significantly altered in SH-SY

289 table subproteome may help mitigate aberrant protein aggregation when protein homeostasis becomes com

290 closely linked to the rate of ubiquitinated protein aggregation, which are themselves associated wit

291 duced lipid microdomain formation as well as protein aggregation, which could be correlated with one

292 n of aberrant proteins can occur and lead to protein aggregation, which is a pathological hallmark of

293 ilitated degradation of TRiC increases polyQ protein aggregation, which is involved in HD.

294 indicates that transcellular propagation of protein aggregation, which is the basis of prion disease

295 llicin-induced protein modifications trigger protein aggregation, which largely stabilizes RpoH and t

296 t any therapeutic that reduces intracellular protein aggregation will benefit all.

297 rstanding the cellular mechanisms regulating protein aggregation will help develop future treatments.

298 Probes for monitoring protein aggregation with a variety of photophysical prop

299 Amyloidosis is a biophysical phenomenon of protein aggregation with biological and pathogenic impli

300 nce links these conditions to the process of protein aggregation, yet it has remained challenging to