ライフサイエンスコーパス: protein isoform

1 redicted to encode an N-terminally truncated protein isoform.

2 ress primarily the liver-enriched inhibitory protein isoform.

3 ree or four repeats present depending on the protein isoform.

4 which are contingent on cell context and the protein isoform.

5 the gene sequence independent of the encoded protein isoform.

6 the UL138 gene, also generates more than one protein isoform.

7 mass spectrometry confirm translation of the protein isoform.

8 y that RE splicing might generate functional protein isoforms.

9 sm responsible for the expression of the two protein isoforms.

10 the generation of eight mRNA and three major protein isoforms.

11 neuron expression of clustered protocadherin protein isoforms.

12 n to express diverse, functionally distinct, protein isoforms.

13 t route for the light-dependent switching of protein isoforms.

14 HCMV gene, UL136, which is expressed as five protein isoforms.

15 UL136 is expressed as five protein isoforms.

16 is gene, including alternative promoters and protein isoforms.

17 cript variants, resulting in three different protein isoforms.

18 d that HVCN1 was expressed in B cells as two protein isoforms.

19 e, predicted to affect expression of shorter protein isoforms.

20 R does not discriminate between inhibitory G protein isoforms.

21 stem cells (hESCs) that lack the individual protein isoforms.

22 binding are regulated by the different SNARE protein isoforms.

23 composed of different combinations of SNARE protein isoforms.

24 cient to account for the levels of expressed protein isoforms.

25 methodology to identify the relative age of protein isoforms.

26 roduce multiple types of mRNA and associated protein isoforms.

27 re ultimately translated into five different protein isoforms.

28 g demonstrates larger molecular weight SEPT9 protein isoforms.

29 the core gene directs the synthesis of core protein isoforms.

30 that comprise a total of at least 10 encoded protein isoforms.

31 in the domain architecture of corresponding protein isoforms.

32 ed (bun), which encodes both large and small protein isoforms.

33 of CCM2 which eventually generated 22 novel protein isoforms.

34 that is due to their expression as multiple protein isoforms.

35 n GPCRs and the alpha subunit of different G protein isoforms.

36 protein, whereas isoforms II-IV are shorter protein isoforms.

37 sm that controls the functional diversity of protein isoforms.

38 that cannot be distinguished from bona fide protein isoforms.

39 so alternatively spliced to produce multiple protein isoforms.

40 uggesting that splicing efficiency can alter protein isoforms.

41 encoding at least 12 functionally different protein isoforms.

42 ely in the nervous system to produce diverse protein isoforms.

43 noncoding splice variants and nonfunctional protein isoforms.

44 riches, and detects disease-associated prion protein isoforms.

45 native splicing gives rise to different Mena protein isoforms.

46 arcomere and changes in contractile filament protein isoforms.

47 Of these, 618 genes have >=5 annotated protein-isoforms.

48 ANKRD55 protein isoforms 005 and 001 were predominantly located

49 cts in concert with adenosine deaminase-like protein isoform 1 (ADAL1) to prevent incorporation of N6

50 hat the protein was adenosine deaminase-like protein isoform 1 (ADAL1).

51 such proteins are transmembrane channel-like protein isoform 1 (TMC1) and tetraspan membrane protein

52 studies implicate transmembrane channel-like protein isoform 1 (TMC1) channels in the mammalian cochl

53 Transmembrane channel-like protein isoforms 1 (TMC1) and 2 (TMC2) have been propose

54 on with BAPTA, in transmembrane channel-like protein isoforms 1/2 (Tmc1:Tmc2) double mutants, and dur

55 Transmembrane channel-like protein isoform-1 (TMC1) has emerged over the past five

56 ive RNA processing, as a small single-domain protein (isoform 3 [iso3]).

57 ion studies have identified ORM (yeast)-like protein isoform 3 (ORMDL3) as a gene associated with sus

58 eotide polymorphisms in the ORM (yeast)-like protein isoform 3 (ORMDL3) gene across different populat

59 studies have identified the ORM (yeast)-like protein isoform 3 (ORMDL3) gene locus on human chromosom

60 ORM (yeast)-like protein isoform 3 (ORMDL3) has recently been identified

61 osis modulator: 2 of its known mitochondrial protein isoforms, 43-kilodaltons and 40-kilodaltons, hav

62 Tripartite motif protein isoform 5 alpha (TRIM5alpha) is a potent antivir

63 d in robust myocyte expression of a distinct protein isoform, a response that was conserved in humans

64 stoma cells TRbeta2 mRNA encodes two TRbeta2 protein isoforms: a predominantly cytoplasmic 54-kDa pro

65 more, the data allowed us to discern between protein isoforms according to expression patterns, which

66 at the level of protein stability, and this protein isoform accumulates particularly in response to

67 ising 441 transcription factor and signaling protein isoforms across 68 Yoruba (YRI) HapMap lymphobla

68 AS) often focused on the spatial patterns of protein isoforms across different tissues.

69 pipe encodes ten putative protein isoforms, all of which exhibit similarity to ver

70 E (ApoE) as a model protein, we developed a protein isoform analysis method utilizing stable isotope

71 Protein isoform analysis revealed that beta-myosin is pr

72 The ApoE protein isoform analysis using SILT allows for the simul

73 Toward scalable protein isoform analysis, we introduce a microfluidic "s

74 or an association between the soluble HLA-G6 protein isoform and pCR in HER2+ breast cancer.

75 he unique capability of fully characterizing protein isoforms and combinatorial post-translational mo

76 oes alternative splicing, producing multiple protein isoforms and mis-splicing has been implicated in

77 sociated with sex-specific expression of Lon protein isoforms and proteolytic activity.

78 o the functions of the alternatively spliced protein isoforms and provide high-confidence hypotheses

79 g is specific for a subset of exocytic SNARE protein isoforms and requires membrane integration of th

80 s of these create complex patterns of intact protein isoforms and species.

81 ion of intact proteins, including individual protein isoforms and specific posttranslationally modifi

82 ocus on obtaining better characterization of protein isoforms and specific PTMs.

83 of chemical synapse expresses a given set of protein isoforms and splice variants adapted to the dema

84 pT peptides to differentiate closely related protein isoforms and to enable the detection of many pos

85 The Orb2 has two protein isoforms, and the rare Orb2A isoform is critical

86 stems need to be able to measure millions of proteins, isoforms, and complexes simultaneously.

87 lipoprotein E family consists of three major protein isoforms: apolipoprotein E4 (ApoE4), ApoE3, and

88 itate discovery of novel RNA transcripts and protein isoforms, applications ranging from neuromuscula

89 Two protein isoforms are generated from three alternatively

90 le to predict their fate in terms of whether protein isoforms are generated or specific transcripts a

91 the vast majority of differentially spliced protein isoforms are not known.

92 integration of the resultant tissue-specific protein isoforms are typically unknown.

93 Protein isoforms are widely expressed in biological syst

94 Quaking protein isoforms arise from a single Quaking gene and bi

95 A diverse repertoire of protein isoforms arising from alternative splicing is ex

96 The diversity of protein isoforms arising from alternative splicing is th

97 Parsing protein isoforms as a function of disease will be essent

98 ealed differences in abundance and number of protein isoforms at numerous steps in glycolysis.

99 BRCA1 BRCT domain-deficient protein isoforms avoid mutation-induced proteasomal degr

100 nes encode two functional enoyl-acyl carrier protein isoforms based on their ability to complement th

101 A dearth of protein isoform-based clinical diagnostics currently hin

102 pression of a specific Ca(V)1.2 beta-subunit protein isoform (beta(2a)).

103 ion and the expression of bone morphogenetic protein isoform (BMPs).

104 APOE in disease risk, involving not only the protein isoforms but also an epigenetically regulated tr

105 proteins control the production of the short protein isoform by suppressing inclusion of NF1 exon 23a

106 efficient translation re-initiation into the protein isoforms C/EBPalpha-p30 and C/EBPbeta-LIP, which

107 /or post-translational generation of various protein isoforms can be indicative of initial pathologic

108 highlights how diverse roles of alternative protein isoforms can contribute to unique aspects of bra

109 F) complex and its interaction with the Fbw7 protein isoforms can take place independently of phospho

110 ay produce a subset of alternatively spliced protein isoform candidates that have higher confidence.

111 We show that loss of Drosophila Apc2 causes protein isoform changes reflecting misregulation of post

112 set of Alzheimer's disease (AD) through apoE protein isoforms changing the probability of amyloid-bet

113 cluding an intronic variant that codes for a protein isoform containing a truncated kinase domain.

114 fibre atrophy and the changes in myofilament protein isoform contents, ssTnT deficiency significantly

115 ially abundant myofibrillar and sarcoplasmic proteins/isoforms contributing to proteomic distances be

116 , we find that alternative Prickle (Pk-Sple) protein isoforms control the polarity of this MT network

117 ouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet und

118 mma coactivator 1-alpha 4 (PGC-1alpha4) is a protein isoform derived by alternative splicing of the P

119 The identification of novel protein isoforms derived from alternatively spliced ie3

120 In the F2 genotypes, the expression of aphid protein isoforms derived from the competent parental lin

121 that is 20 exons long and produces two known protein isoforms differing in C-terminal amino acid comp

122 that human transcript diversity (and thereby protein isoform diversity) remains under-characterised,

123 r identified a role of APA in switching Araf protein isoforms during microglia activation, impacting

124 In this study, we discovered a new protein isoform encoded by KIAA0317, termed fibrosis-ind

125 lgS97, a SAP97 homolog, and one of two major protein isoforms encoded by dlg1 via alternative splicin

126 AMCase protein isoforms, encoded by two gene-wide haplotypes, a

127 ve splicing events that favors expression of protein isoforms essential for EMT, cytoskeletal rearran

128 eta is a transcription factor in which three protein isoforms exist because of alternative translatio

129 We also show that the dmPTB protein isoform expressed in the male germline is by far

130 response depended on the mRNA variant or the protein isoform expressed, on the specificity of the cel

131 Individual knockout plants for five 14-3-3 protein isoforms expressed in rosettes lacked circadian

132 d simultaneous quantification of contractile protein isoform expression and associated post-translati

133 ive mRNA splicing is a mechanism to regulate protein isoform expression and is regulated by alternati

134 hat aldosterone selectively increased 14-3-3 protein isoform expression and that the association of 1

135 stic and predictive value of HLA-G and HLA-F protein isoform expression patterns in patients with bre

136 lt from structural maturation and changes in protein isoform expression.

137 The single Fgf8 gene in mice produces eight protein isoforms (Fgf8a-h) with different N-termini by a

138 A panel of purified fluorescent protein isoforms (FPs) was screened for the ability to d

139 which allows the generation of more than one protein isoform from a single gene.

140 of synaptic modulation exerted by different protein isoforms from a single gene locus is dependent o

141 e splicing generates multiple transcript and protein isoforms from the same gene and thus is importan

142 or the production of multiple transcript and protein isoforms from the same gene.

143 exon VII results in two naturally occurring protein isoforms: full-length Ets1 (p51-Ets1) and Ets1(D

144 acterization of the soluble CTLA-4 (sCTLA-4) protein isoform generated by an alternatively spliced mR

145 res, demonstrating functional cooperation of protein isoforms generated by coordinated alterative spl

146 The major protein isoforms generated by P1 and P2 are RUNX1C and R

147 teristics of some genes, the extent to which protein isoforms globally contribute to functional compl

148 gene is alternatively spliced producing two protein isoforms: GPBP and GPBPDelta26.

149 sue-specific activity of alternative Pk-Sple protein isoforms has been observed to rectify the interp

150 These protein isoforms have a conserved N-terminus (signal pep

151 Four membrane-bound and three soluble HLA-G protein isoforms have been described, which have differe

152 Antibodies specific to p53 protein isoforms have proven difficult to develop, thus

153 owed a reduced expression of the short Homer protein isoform Homer 1a, and an increased coupling of m

154 We reveal that because the most common protein isoform in normal adult breast and breast tumors

155 further investigation of the truncated MTMR2 protein isoform in Schwann cells and in CMT4B1 pathogene

156 nce that DeltaNp63alpha, the predominant p63 protein isoform in squamous epithelia and YB-1, can phys

157 e midzone protein [5], appeared as two short protein isoforms in addition to the full-length protein.

158 The pathological prion protein isoforms in BASE strain-infected humanized Tg mo

159 Intriguingly, overexpressing the two MTMR2 protein isoforms in HeLa cells revealed that both locali

160 odes an E3 ubiquitin ligase with three known protein isoforms in humans.

161 The assay reported protein isoforms in immune-purified sample and raw cell

162 To measure protein isoforms in individual mammalian cells, we repor

163 utions of variable expression of myofilament protein isoforms in mediating the timing of myocardial a

164 easured the expression of M1 and M2 mRNA and protein isoforms in mouse tissues, tumor cell lines, and

165 ed as an inefficient start codon to generate protein isoforms in mouse.

166 ay (NIA) to quantify total and low-abundance protein isoforms in nanoliter volumes.

167 plicing of the tau gene, MAPT, generates six protein isoforms in the adult human central nervous syst

168 xpressed different mRNA variants and whirlin protein isoforms in the cochlea and retina, where these

169 as multigene families that give rise to many protein isoforms in the same individual displaying high

170 mature NT-3 are the predominant NGF and NT-3 protein isoforms in the SCG, yet it is unknown whether t

171 ase, showed the presence of pathogenic prion protein isoforms in the spleen, indicating that the BASE

172 PSD-95, Discs-large, ZO-1) domain-containing protein isoforms, in the modulation of the gut immune re

173 ical labeling, as well as previously unknown protein isoforms including pSPs.

174 omologous corrinoid/methyltransferase fusion protein isoforms involved in methyl sulfide metabolism.

175 MYLK encodes protein isoforms involved in multiple components of the

176 e human tissues; for hKCNE4, only the longer protein isoform is detectable.

177 to specifically detect and quantify receptor protein isoforms is a major impediment to functional stu

178 The aspect of multiple protein isoforms is also considered in the selection tre

179 get of rapamycin) mRNA, generating a shorter protein isoform lacking catalytic activity.

180 EBPbeta is an intronless gene encoding three protein isoforms--LAP1, LAP2, and LIP.

181 defects in splicing could lead to changes in protein isoform levels, they could also impact gene expr

182 hese transcripts, which produce two distinct protein isoforms localizing to the plasma membrane and t

183 More importantly, we identified a third protein isoform, Ly108-H1, which is absent in two lupus-

184 RCAN1 gene, which can generate several RCAN1 protein isoforms, may be at least partially responsible

185 istent with requirements for tissue-specific protein isoforms needed to sustain muscle-specific funct

186 uroplastin gene encodes two synapse-enriched protein isoforms, Np55 and Np65, which are transmembrane

187 d expression of the Gad1 gene-encoded 67-kDa protein isoform of glutamic acid decarboxylase (GAD67) i

188 The major protein isoform of p63 expressed in SCC is DeltaNp63alph

189 hese methods to a number of the amyloid-beta protein isoforms of Abeta40 and Abeta42 and showed that

190 These results suggest that the two protein isoforms of AEBP2 may have opposite functions fo

191 psilon3/epsilon4, which translate into three protein isoforms of apoE2, E3 and E4.

192 We identify two distinct protein isoforms of CEP135 that antagonize each other to

193 rovides cells with the opportunity to create protein isoforms of differing, even opposing, functions

194 ur splice variants of the mRNA encoding four protein isoforms of EGFR in humans, named I through IV.

195 demonstrated the predicted existence of two protein isoforms of Irgm1 derived from differential spli

196 Of the two protein isoforms of Orb2, the amyloid-like oligomer form

197 a-7sv4 and canine mda-7sv5) that encode four protein isoforms of the canine MDA-7 protein.

198 C9orf72 encodes two C9orf72 protein isoforms of unclear function.

199 ement mice "humanized" for the coding exons (protein isoform) of human epsilon2 (apoE2), epsilon3 (ap

200 K 293 cells, expression of P2RX7L produces a protein isoform, P2X7L, that forms a heteromer with P2X7

201 ed as AUF1 (A + U-rich RNA-binding factor 1) protein isoform p45 (a product of the heterogeneous nucl

202 rofiling to functionally compare hundreds of protein isoform pairs.

203 major question in the field is why two human protein isoforms, PAPSS1 and -S2, are required that cann

204 434 different genes, with an average of 5.22 protein isoforms per gene.

205 y three prolyl hydroxylase domain-containing protein isoforms (Phd1, Phd2 and Phd3).

206 ted from human SMN genes and reveals a novel protein isoform predicted to be stably expressed during

207 Self-perpetuating amyloid-based protein isoforms (prions) transmit neurodegenerative dis

208 y, our findings indicate that the short DOG1 protein isoform produced from the proximally polyadenyla

209 Since we demonstrated that the protein isoform produced through premature polyadenylati

210 y, depletion of APC altered the p120-catenin protein isoform profile.

211 The scrapie prion protein isoform, PrPSc, is a prion-associated marker tha

212 Here we identify a short protein isoform (pUL138-S) initiating from codon 16 that

213 The existence of neuron-specific endocytic protein isoforms raises questions about their importance

214 exons, 9, 10, and 11, resulting in predicted protein isoforms ranging from 82 to 64 kDa.

215 y allow for the potential influence of these protein isoforms, relying instead on cDNA-based transgen

216 ever, selective quantification of individual protein isoforms remains a challenge, because they simul

217 functions we have characterized the mRNA and protein isoform repertoire of PTBP3.

218 cnn), an essential gene encoding centrosomal protein isoforms required during syncytial development i

219 evant to detection of currently unmeasurable protein isoforms responsible for cancer progression.

220 Loss of the liver-enriched inhibitory protein isoform results in increased ATF4 mRNA levels in

221 ng fluorescently labeled tonoplast intrinsic protein isoforms reveal an altered tonoplast morphology

222 the Drosophila PcG protein SCM, encodes two protein isoforms: SCML2A that is bound to chromatin and

223 results in a novel mRNA coding for an sgp130 protein isoform (sgp130-E10) of 70-80 kDa.

224 The inaE-encoded protein isoforms show high sequence similarity to known

225 As remained constant, but the 929-amino-acid protein isoform showed increases up to about 3-fold in c

226 Experimental analysis of these protein isoforms showed that alternative splicing regula

227 001) per 1-SD increment in apolipoprotein(a) protein isoform size in serum due to rs2457564, which wa

228 le1b mice; for instance, the presence of the protein isoform Slamf6-H1 in Sle1b.Slamf6-H1 mice mitiga

229 ping of exon 7 and production of an unstable protein isoform, SMNDelta7.

230 that keratinocytes express all seven 14-3-3 protein isoforms, some of which form heterodimers with 1

231 We have developed tools for IHC of RREB1 protein isoform-specific amplification of RREB1 mRNA and

232 tr1B, and ctr1C, little is known about their protein isoform-specific roles.

233 ld-type, catalytic active, dominant-negative protein isoforms strengthened the association between ph

234 ose predicted to have substantial effects on protein isoform structure and function (e.g., intron ret

235 the 35-kD subunit of U2AF gives rise to two protein isoforms (termed U2AF35a and U2AF35b) that are e

236 predominantly the shorter wild-type TBC1D24 protein isoform that omits the micro-exon.

237 codon (PTC), that leads to a 65kDa truncated protein isoform that opposes full-length eIF2Bepsilon to

238 We developed two methods to identify protein isoforms that are both phosphorylated and ubiqui

239 y and identified ERICH3 mRNA transcripts and protein isoforms that are highly expressed in central ne

240 The ATP13A2 gene encodes at least three protein isoforms that arise by alternate splicing.

241 ated glycoprotein (MAG), which generates two protein isoforms that associate with distinct cellular c

242 family member, AKAP13, encodes for multiple protein isoforms that contain binding sites for protein

243 Although all of these transcripts encode protein isoforms that contain the conserved C-terminal z

244 ation (CID)-FTICR MS was applied to identify protein isoforms that contribute to the separation of th

245 e, we report that mouse Mbnl3, which encodes protein isoforms that differ in the number of tandem zin

246 gene is alternatively spliced, resulting in protein isoforms that differ in the number of ubiquitin-

247 ternative first exons which produce multiple protein isoforms that differ in their N-terminal sequenc

248 The IGF1/Igf1 gene encodes multiple protein isoforms that differ in tissue expression, poten

249 pacity by generating alternatively initiated protein isoforms that may have distinct biological funct

250 malian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even

251 Alternative splicing produces three Fbw7 protein isoforms that occupy distinct compartments: Fbw7

252 The Fbw7 locus encodes three protein isoforms that occupy distinct subcellular locali

253 s, splicing and editing events, and inferred protein isoforms that previously eluded discovery using

254 and -gamma gene clusters encode more than 50 protein isoforms, the combinatorial expression of which

255 iscovered that the naturally occurring UL138 protein isoforms, the full-length long isoform of UL138

256 ific localization of two tonoplast intrinsic protein isoforms, the small leaf vacuoles were identifie

257 riants that may encode functionally distinct protein isoforms, the transcriptomes of various tissues

258 ene Ultrabithorax (Ubx) produces a family of protein isoforms through alternative splicing.

259 omosome sequence polymorphisms identified by protein isoforms, transcribed mRNA, and methylation stat

260 a large number of genes coordinately express protein isoform transitions regulated by alternative spl

261 s to temporarily repress expression of adult protein isoforms until the final maturation of the neuro

262 sses including structured representations of protein isoforms, variants and modified forms.

263 Individual mRNAs generate up to three protein isoforms via alternative translation initiation

264 of a prion as an infectious self-propagating protein isoform was initially proposed to explain certai

265 stant mice and one of the two possible Iigp2 protein isoforms was preferentially expressed in suscept

266 logical activity of this unique PARP1 mutant protein isoform, we have uncoupled the transactivation a

267 ytotic processes mediated by different SNARE protein isoforms, we systematically analyzed the interac

268 The mutant protein isoforms were functionally characterized by meas

269 nalysis indicated that only two of four AUF1 protein isoforms were present in the uterine cytosolic e

270 odies could distinguish among the four ERCC1 protein isoforms, whereas only one isoform produced a pr

271 HMGA1 encodes the HMGA1a and HMGA1b protein isoforms, which function in regulating gene expr

272 have provided improved detection of C9orf72 protein isoforms, which will help elucidate its physiolo

273 tein ignoring the multiple splice-variant or protein-isoforms, which might contribute to unexpected t

274 ) is a naturally occurring, lower oligomeric protein isoform whose expression is increased in cancer.

275 lexity of the eukaryotic proteome-generating protein isoforms whose functions can be novel, diverse,

276 allows the cell to generate multiple RNA and protein isoforms whose levels change upon glucose deplet

277 ions, such as disulfide linkages, as well as protein isoforms whose sequences are absent from a datab

278 nitis pigmentosa (XLRP) and encodes multiple protein isoforms with a common N-terminal domain homolog

279 this differential TSS utilization results in protein isoforms with additional domains or targeted to

280 promoter usage, resulting in light-dependent protein isoforms with altered subcellular localization t

281 he AKR1B15 gene transcript gives rise to two protein isoforms with different N termini: AKR1B15.1 is

282 ated through alternative splicing to produce protein isoforms with differing N- and C-terminal domain

283 re subject to alternate splicing to generate protein isoforms with divergent functions.

284 mRNA variants, RA and RB, which translate to protein isoforms with divergent neuroprotective capaciti

285 vely spliced transcripts to encode different protein isoforms with individual functions in the cell,

286 ns or skipping of the edited exon leading to protein isoforms with internal sequence deletions.

287 ene, is expressed as at least five different protein isoforms with overlapping and unique functions.

288 codon readthrough (SCR), producing extended protein isoforms with potential novel functions.

289 The scIEF assay resolves protein isoforms with resolution down to a single-charge

290 polyadenylation (IPA) can generate truncated protein isoforms with significantly altered functions.

291 in the tau primary transcript gives rise to protein isoforms with three (3R) or four (4R) MT binding

292 h exons 3 and 4 encodes MeCP2-e1 or MeCP2-e2 protein isoforms with unique amino termini.

293 t variants resulting in three possible Sirt3 protein isoforms with variable lengths at the N-terminus

294 of the neuronal nitric oxide synthase (nNOS) protein isoform within the rostral (RVLM) and caudal (CV

295 broad-spectrum neutralization across various protein isoforms within these protein families is a nece

296 process that includes facile measurement of protein isoforms would accelerate development of effecti

297 Recombinant protein isoforms WT-OCLN and OCLN-ex7ext, which retained

298 ndergoes alternative splicing to produce two protein isoforms, XBAT35.1 and XBAT35.2.

299 us to human RPGR, because it encodes similar protein isoforms (ZFRPGR2(ORF15), ZFRPGR2(ex1-17)) and c

300 protein, Aquaporin-3 and the tight junction protein isoform, ZO-1 alpha+.