ライフサイエンスコーパス: protein kinase

1 istinct activation of Akt, a serine/theonine protein kinase.

2 closely related AGC-family serine/threonine protein kinases.

3 ers of the AMPK/SNF1-subfamily of basophilic protein kinases.

4 ty of different effectors, including several protein kinases.

5 ytic replication cycle through virus-encoded protein kinases.

6 been profiled on near-kinome-wide panels of protein kinases.

7 t mechanism of post-translational control of protein kinases.

8 turally related PI3 (lipid) and PI3K-related protein kinases.

9 Calcium dependent protein kinase 1 (CDPK1) is an essential Ser/Thr kinase

10 nts in MAPK1, encoding the mitogen-activated protein kinase 1 (i.e., extracellular signal-regulated p

11 enzyme called mitogen- and stress-activated protein kinase 1 (MSK1).

12 , GFAP, and phosphorylated mitogen-activated protein kinase 1 (pERK) were assessed in whole mount spe

13 the human PRKG1 gene encoding cGMP-dependent protein kinase 1 (PKG1) leads to thoracic aortic aneurys

14 Receptor-interacting protein kinase 1 (RIPK1) is a serine/threonine kinase th

15 RIPK1 (receptor-interacting serine/threonine-protein kinase 1), which acts as a master switch that co

16 ase B1 or by the Ca(2+)/calmodulin-dependent protein kinase 2 (CaMKK2).

17 rovide evidence that homeodomain interacting protein kinase 2 (HIPK2) and its kinase activity promote

18 nase 1 (i.e., extracellular signal-regulated protein kinase 2, ERK2), cause a neurodevelopmental dise

19 We found that CBL-interacting protein kinase 23 (CIPK23) interacts with both phot1 and

20 Sucrose-non-fermenting-1-related protein kinase-2s (SnRK2s) are critical for plant abioti

21 8- and receptor-interacting serine/threonine-protein kinase 3 (RIPK3)-mediated inflammatory cell deat

22 iggers receptor-interacting serine/threonine-protein kinase 3 (RIPK3)-mediated pathways of apoptosis

23 otic pathway, including receptor-interacting protein kinase-3 (RIPK3), mixed lineage kinase-like (MLK

24 entry program by activating cyclin-dependent protein kinase 4/6 (CDK4/6).

25 raft mouse models revealed mitogen-activated protein kinase 7/matrix metallopeptidase 9 (MAPK7/MMP9)

26 N), zeta chain of T-cell receptor-associated protein kinase 70 (ZAP-70), and three mitogen-activated

27 70 (zeta chain of T cell receptor-associated protein kinase 70).

28 Dynamic subcellular regulation of protein kinase A (PKA) activity is important for the mot

29 cyclic nucleotide-gated (CNG) channels or by protein kinase A (PKA) activity.

30 (NGF) as well as multiple kinases, including protein kinase A (PKA) and C (PKC).

31 (Epac 1-2)] are alternative cAMP targets to protein kinase A (PKA) and Epac2 is abundant in the cere

32 ing unbiased kinase profiling, we identified protein kinase A (PKA) as an active kinase in small cell

33 e protein phospholamban (PLN) is targeted by protein kinase A (PKA) at Ser(16) and by Ca(2+)/calmodul

34 ignaling promotes the formation of a SMAD3/4-protein kinase A (PKA) complex that activates C-terminal

35 ing Ras-cAMP-PKA pathway at the level of the protein kinase A (PKA) enzyme.

36 , cyclic adenosine monophosphate (cAMP), and Protein Kinase A (PKA) exist in an oscillatory circuit c

37 Protein Kinase A (PKA) exists as a tetrameric holoenzyme

38 rat ventricular cardiomyocytes is driven by protein kinase A (PKA) phosphorylation.

39 LI-1, and inhibitors of adenylyl cyclase or protein kinase A (PKA) prevented the effects of Lgmn.

40 gh PAR(2) Inhibitors of adenylyl cyclase and protein kinase A (PKA) prevented the effects of Lgmn.

41 Luteinizing hormone (LH) activates protein kinase A (PKA) signaling in luteal cells, increa

42 ion to mitochondria and its interaction with protein kinase A (PKA), a known node in the beta-adrener

43 odulin-dependent protein kinase II (CaMKII), protein kinase A (PKA), protein kinase C (PKC), and AMPA

44 s a multivalent binding protein that targets protein kinase A (PKA), RNAs, and other signaling enzyme

45 Synaptic SK2 levels are also regulated by protein kinase A (PKA), which phosphorylates SK2 in its

46 nses to subsequent stresses, as seen for the protein kinase A (PKA)-mediated general stress response

47 erotrimeric Gbetagamma subunits, PIP(3), and protein kinase A (PKA).

48 associated with cAMP-mediated activation of protein kinase A (PKA).

49 taneous measurement of cytosolic calcium and protein kinase A activity are shown, but the PIE-FLIM ap

50 Dual-specificity protein kinase A anchoring protein 1 (dAKAP1) is a multi

51 ed a novel mTORC1-interacting protein called protein kinase A anchoring protein 8L (AKAP8L).

52 -kinase anchoring proteins (AKAPs) that bind protein kinase A and other important signalling enzymes

53 Persistent modulation was protein kinase A dependent and associated with a reducti

54 Since protein kinase A inhibition by H-89 and knockdown of bet

55 This effect is not mediated by the canonical protein kinase A pathway but rather, through direct acti

56 with GO enrichment for neuronal function and protein kinase A pathways.

57 odomains, while Zhao and coworkers find that protein kinase A regulatory subunits assemble liquid dro

58 llular signal-regulated kinase signaling and protein kinase A substrate dephosphorylation.

59 Although both PGE(2) (via protein kinase A) and FGF-2 (via protein kinase B, also

60 In the myocardium, PKARIalpha (type-1 protein kinase A) can be reversibly oxidized, forming in

61 In model organisms, it impairs PKA (protein kinase A) phosphorylation, increases calcium sen

62 hich via CCR1/CCR2 on cancer cells, activate protein kinase A, leading to enhanced malignant cell gly

63 Ryanodine receptor was protein kinase A-hyperphosphorylated, S-nitrosylated, ox

64 different 26S component than is modified by protein kinase A.

65 m/calmodulin-dependent protein kinase II and protein kinases A and C regulate the activity of T-type

66 proteins form signaling complexes containing protein kinases A and C, which phosphorylate and activat

67 ntly of energy stress-mediated AMP-activated protein kinase activation and possibly through NADPH dep

68 enhanced collagen content and AMP-activated protein kinase activation in the scar, increased vessel

69 PI induced adenosine monophosphate-activated protein kinase activation of acetyl-coenzyme A carboxyla

70 ations of possible phosphorylation states on protein kinase activity are difficult to study experimen

71 Our findings highlight the importance of the protein kinase activity of PCK1 in the activation of SRE

72 ss-responsive activation of 5'-AMP-activated protein kinase (AMPK) and neuroprotective induction of a

73 Yeast AMP-activated protein kinase (AMPK) directly phosphorylates Tda1 to go

74 vity of adenosine 5'-monophosphate-activated protein kinase (AMPK) in HSPC, dramatically increasing m

75 AMP-activated protein kinase (AMPK) is a key energy sensor, activated

76 AMP-activated protein kinase (AMPK) is a key regulator of energy metab

77 Adenosine monophosphate-activated protein kinase (AMPK) is an evolutionary conserved serin

78 Activation of AMP-activated protein kinase (AMPK) results in vasodilatation and is t

79 ) is decreased due to impaired AMP-activated protein kinase (AMPK) signaling.

80 e, we investigated the role of AMP-activated protein kinase (AMPK), a master regulator of energy meta

81 deprivation-sirtuin-1 (SIRT1), AMP-activated protein kinase (AMPK), and hypoxia-inducible factors (HI

82 e (BBR), a potent activator of AMP-activated protein kinase (AMPK), can reduce beta-catenin expressio

83 nificant activation of hepatic AMP-activated protein kinase (AMPK), peroxisome proliferator-activated

84 SIRT1), forkhead box O (FoxO), AMP-activated protein kinase (AMPK), peroxisome proliferator-activated

85 mediated by the stimulation of AMP-activated protein kinase (AMPK).

86 ling pathways, such as the mitogen-activated protein kinase and AKT signaling cascades.

87 ess-responsive induction of 5'-AMP-activated protein kinase and autophagy.

88 Activation of mitogen-activated protein kinases and NFkappaB signaling was unaffected by

89 Mitochondrial targeting of protein kinases and protein phosphatases provides a mean

90 Master protein kinases and transcription factors mediate the gr

91 e cellular energy sensor AMPK (AMP-activated protein kinase), and decreases EC proliferation without

92 being ankyrin repeat, P-loop NTPase, F-box, protein kinase, and membrane occupation and recognition

93 cei mutants that overexpress known essential protein kinases, and identified CLK1 as a primary target

94 LegK7 is structurally similar to eukaryotic protein kinases, and that MOB1A directly binds to the Le

95 Protein kinases are a large family of druggable proteins

96 Calcium-regulated protein kinases are key components of intracellular sign

97 ated kinase), JNK, and p38 mitogen-activated protein kinases as well as NFkappaB (nuclear factor kapp

98 We show that inhibition of CaMKII, a Ser/Thr protein kinase associated with excitability, synaptic pl

99 feration and death, but aberrantly increased protein kinase B (AKT) phosphorylation, elevated Vcan tr

100 he protein kinase B pathway by injecting the protein kinase B activator SC79 in Lgr4(-/-) mice can ef

101 Importantly, the reactivation of the protein kinase B pathway by injecting the protein kinase

102 etylase 8 led to the inhibition of EphA2 and protein kinase B phosphorylation, reduced invasion, and

103 Even though mTOR/protein kinase B signaling is important for adipogenesis

104 PGE(2) (via protein kinase A) and FGF-2 (via protein kinase B, also known as AKT) depended on activat

105 50% (of phosphorylated IGF1R, phosphorylated protein kinase B, and phosphorylated MAPK kinase), sugge

106 thway, including key signaling intermediates protein kinase B, extracellular signal-regulated kinase

107 nses 1 (REDD1), a negative regulator of mTOR/protein kinase B, is poorly understood.

108 ate lyase (ACLY) in a TGF-beta receptor/PI3K/protein kinase B-dependent manner, to regulate hepatic a

109 ts of multisite phosphorylation on the plant protein kinase brassinosteroid insensitive 1-associated

110 lial cells via JNK and p38 mitogen-activated protein kinase but not NF-kappaB.

111 l cell polarity, with expression of atypical protein kinase C (aPKC) at the contact-free domain, nucl

112 gulated by endocytic trafficking, and direct protein kinase C (PKC) activation acutely diminishes DAT

113 Activation of TRPC1-based SOCs requires protein kinase C (PKC) activity, which is proposed to ph

114 Stimulation of TRPC1-based SOCs requires protein kinase C (PKC) activity, with store-operated PKC

115 DOPr endocytosis and endosomal signaling by protein kinase C (PKC) and extracellular signal-regulate

116 ere, we demonstrate that classical and novel protein kinase C (PKC) isoforms distinctly regulate card

117 Although previous work suggests that protein kinase C (PKC) isoforms play a role in cardiac f

118 kinase II (CaMKII), protein kinase A (PKA), protein kinase C (PKC), and AMPA receptor genes that pla

119 -catalyzed PI(4,5)P(2) hydrolysis, activates protein kinase C (PKC).

120 prompts the stimulation of NADPH oxidase and protein kinase C (PKC).

121 ed proteins from public databases identified protein kinase C (PKC)zeta as a TRIM32-associated protei

122 Compound screening identified a protein kinase c activator that promotes maturation of p

123 ts of G protein-coupled serotonin receptors, protein kinase C agonists, and a microbial metabolite no

124 y reversal by histone deactylase inhibitors, protein kinase C agonists, and proteasome inhibitors wit

125 erapy identified a crucial role for enhanced protein kinase c alpha (PKCalpha) signaling and downstre

126 Kinase inhibitors aimed at blocking protein kinase C and c-Jun N-terminal kinase had no effe

127 Purkinje cell-specific inhibition of protein kinase C decreased and phase-shifted the transla

128 -CUB-domain containing protein 1 (CDCP1) and protein kinase C delta (PKCdelta)-in 56 formalin-fixed,

129 quency-dependent activation of PKC(epsilon) (protein kinase C epsilon).

130 ynia induced by inflammatory injuries, while protein kinase C gamma (PKCgamma) neurons at the lamina

131 D300f receptor cytoplasmic tail inhibits the protein kinase C phosphorylation of a threonine and is a

132 zyme A reductase, phospholipase A2 receptor, protein kinase C zeta type, tubulin beta-4B class IVb, v

133 oprostanes, NOX2 (NADPH oxidase 2), and PKC (protein kinase C) were measured in obese mice and compar

134 duced phosphorylation of the kinases Lyn and protein kinase C-beta and MAPKs MKK-3/6 and p38MAPK or t

135 The differential impact of a protein kinase C-delta TAT peptide inhibitor (PKCdelta-i

136 s via separate information pathways and that protein kinase C-dependent mechanisms regulate translati

137 The Ras-binding domain of the protein kinase c-Raf (c-Raf-RBD) is the tightest known b

138 ernalization, possibly through activation of protein kinase C.

139 e (ZIP), which was originally developed as a protein kinase C/Mzeta (PKCzeta/PKMzeta) inhibitor, is k

140 enzymatic activity of PLCdelta1, leading to protein kinase C/protein kinase D/extracellular signal-r

141 Neither agent's activity depends on protein kinase C; nor do they inhibit class I/II histone

142 n shown in Xenopus oocytes to be affected by protein kinases C and A, we used different nonselective

143 e alpha-synuclein protein and phosphorylated protein kinase Calpha, as well as reduced abundance of l

144 ly selective oral inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity, we

145 The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has well-est

146 nd its colocalization with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

147 its regulatory (R) domain by cAMP-dependent protein kinase catalytic subunit (PKA).

148 el, resulting in inhibition of DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) recruitment

149 Protein kinase Cbeta (PKCbeta) expressed in mammalian ce

150 at responses, whereas de novo translation in protein kinase Cdelta-expressing inhibitory neurons in t

151 (PIKKs) are large Serine/Threonine (Ser/Thr)-protein kinases central to the regulation of many fundam

152 d genes, including the conserved herpesvirus protein kinase (CHPK) that has multifunctional propertie

153 (CBL) calcium sensors and 26 CBL-Interacting Protein Kinases (CIPKs) of Arabidopsis (Arabidopsis thal

154 red that through the activities of the viral protein kinase conserved across herpesviruses and two ce

155 ith the defense-associated calcium-dependent protein kinase CPK1 and present indications this interac

156 eport that the Arabidopsis calcium-dependent protein kinase CPK3 is a key regulator of both pattern-t

157 Calcium-dependent protein kinases (CPKs) and calcineurin-B-like proteins (

158 ilization, cAMP formation, and activation of protein kinase D (PKD) and PKA, but not beta-arrestin re

159 ty of PLCdelta1, leading to protein kinase C/protein kinase D/extracellular signal-regulated kinase1/

160 Protein kinase D1 (PRKD1) inhibits cell motility and is

161 ysis and ChIP-PCR together demonstrated that protein kinase D1 (Prkd1) is a direct transcriptional ta

162 ls displayed increased p38 mitogen-activated protein kinase-dependent Ripk1-independent IL-1 and tumo

163 esis of biologically important AMP-activated protein kinase deprived of any metal Pd contamination.

164 Protein kinases direct polarized growth by regulating th

165 d region (3'UTR) of the dystrophia myotonica protein kinase (DMPK) gene.

166 utations of PRKDC encoding the DNA-dependent protein kinase (DNA-PK) catalytic subunit (DNA-PKcs) are

167 DNA-dependent protein kinase (DNA-PK) plays a critical role in the non

168 As its name implies, the DNA dependent protein kinase (DNA-PK) requires DNA double-stranded end

169 The DNA-dependent protein kinase (DNA-PK), which comprises the KU heterodi

170 The DNA-dependent protein kinase (DNA-PK), which is composed of the KU het

171 s also induced in a cGAS-independent and DNA-protein kinase (DNA-PK)-dependent manner.

172 Multiple UNC-89 isoforms contain two protein kinase domains.

173 tation in dual serine/threonine and tyrosine protein kinase (dstyk) lead to CS-like vertebral malform

174 e lower levels of ATP and have AMP-activated protein kinase dysfunction.

175 studies demonstrate that the cGMP-dependent protein kinase EGL-4 determines the timescale of thresho

176 A targeted screen of conserved protein kinase-encoding genes yielded gsk-3 (an ortholog

177 Eukaryotic protein kinases (EPKs) catalyze the transfer of a phosph

178 ase 70 (ZAP-70), and three mitogen-activated protein kinases (extracellular signal-regulated kinase,

179 The Akt serine/threonine protein kinase family is linked to maintaining latency.

180 l NO synthase (eNOS), cyclic GMP (cGMP), and protein kinase G (PKG) activity independently of diet, w

181 ve suggested that phosphorylation of RyR2 by protein kinase G (PKG) might contribute to the cardiopro

182 edly post-translationally enhanced by direct protein kinase G (PKG) phosphorylation at S20 (mouse, S1

183 NO activates protein kinase G with the subsequent production of cGMP,

184 involve at least two of the stress-activated protein kinases (GCN2 and PERK) that act on the translat

185 phosphorylated at S199 (hTau-S199-P) by the protein kinase glycogen synthase kinase 3beta (GSK3beta)

186 SPEG (striated preferentially expressed protein kinase) has been identified as the sixth gene as

187 Recent studies of atypical protein kinases have highlighted the structural similari

188 (OGT) for Drosophila homeodomain-interacting protein kinase (Hipk)-induced growth abnormalities in re

189 In a kinome-wide screen of 468 protein kinases, HS-243 had exquisite selectivity toward

190 t Ser(16) and by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) at Thr(17) beta-Adrenergic st

191 Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is an oligomeric enzyme with

192 Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in Ca(2+

193 Calcium-calmodulin dependent protein kinase II (CaMKII) regulates many forms of synap

194 In addition, calcium/calmodulin-dependent protein kinase II (CaMKII), protein kinase A (PKA), prot

195 Ca(2+) through a Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-mediated mechanism, and CaMKI

196 knowledged that calcium/calmodulin-dependent protein kinase II and protein kinases A and C regulate t

197 tor synapses via Ca(2+)/calmodulin-dependent protein kinase II.

198 CaMKII (Ca(2+)/calmodulin-dependent protein kinase-II) protein-expression, CaMKII-dependent

199 mRNA but not of Ca(2+)/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha) mRNA in dendrites.

200 acterization of prokaryotic serine/threonine protein kinases in bacterial pathogens is emerging as an

201 informatics screen, we searched for putative protein kinases in the intracellular bacterial pathogen

202 Conversely, after dual MET/mitogen-activated protein kinase inhibition, tumor growth was significantl

203 7-trihydroxyisoflavone), a tyrosine-specific-protein kinase inhibitor, has been shown to exert an ant

204 udil, a selective Rho-associated coiled-coil protein kinase inhibitor, on corneal allograft survival.

205 acterization of the amidobenzimidazoles (AB) protein kinase inhibitors that show nanomolar potency ag

206 our multi-component explainable framework on protein kinase inhibitors, it can be extended across the

207 Targeting of the mitogen-activated protein kinase-interacting kinase (MNK1/2) and its phosp

208 The ataxia-telangiectasia mutated (ATM) protein kinase is widely known for its function as a chi

209 responses by activating the c-Jun N-terminal protein kinase (JNK) and NF-kappaB pathways; however, th

210 on (STAT) (ruxolitinib) or mitogen-activated protein kinase kinase (MEK) (trametinib) and with STAT3

211 neally for 3 d or with the mitogen-activated protein kinase kinase inhibitor selumetinib by oral gava

212 genase kinase 1, Akt, Raf, mitogen-activated protein kinase kinase, and ERK1/2.

213 The calcium-calmodulin-dependent protein kinase kinase-2 (CaMKK2) is a key regulator of c

214 ough LF is known to cleave mitogen-activated protein kinase kinases (MEKs/MKKs) and some variants of

215 ion and response to salicylic acid (SA), and protein kinase leucine-rich receptors (PK-LRR).

216 e that the conserved beta-3 strand lysine of protein kinases (Lys111 of PDK1) functions as an integra

217 MADD, the mitogen-activated protein kinase (MAPK) activating death domain protein, r

218 nd sustained activation of mitogen-activated protein kinase (MAPK) and AKT.

219 The expression of mitogen-activated protein kinase (MAPK) and endothelial NO synthase (eNOS)

220 interfaces interfered with mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase sign

221 hway, the first described mitogen-associated protein kinase (MAPK) cascade, mediates multiple cellula

222 gens often target the host mitogen-activated protein kinase (MAPK) network to suppress host immune re

223 -arrestin recruitment, and mitogen-activated protein kinase (MAPK) pathway activation.

224 multiple components of the mitogen activated protein kinase (MAPK) pathway enhancing GFP(rare) expres

225 Identifying additional mitogen-activated protein kinase (MAPK) pathway regulators is invaluable i

226 iated, in part, by the p38 mitogen-activated protein kinase (MAPK) pathway responding to oxidative st

227 GFR2b relied on downstream mitogen-activated protein kinase (MAPK) pathways.

228 ions which activate p44/42 mitogen-activated protein kinase (MAPK) signaling are found in half of mye

229 dead BRAF variants amplify mitogen-activated protein kinase (MAPK) signaling by dimerizing with and a

230 el Cacophony (Cac) and the mitogen-activated protein kinase (MAPK) signaling cascade.

231 tic alterations within the Mitogen Activated Protein Kinase (MAPK) signaling network that promote unp

232 entially regulated through mitogen-activated protein kinase (MAPK) signaling or genetic alteration ac

233 ranscription 3 (STAT3) and mitogen-activated protein kinase (MAPK) signaling pathways in intestinal a

234 -Jun amino-terminal kinase mitogen-activated protein kinase (MAPK) signaling to elicit a robust proin

235 Elevated Pi activates mitogen-activated protein kinase (MAPK) signaling, encompassing extracellu

236 ssing Raf-1 activation and mitogen-activated protein kinase (MAPK) signaling.

237 ated in focal adhesion and mitogen-activated protein kinase (MAPK) signaling.

238 aB activator 1 (Act1), p38 mitogen-activated protein kinase (MAPK), Jun NH2-terminal kinase (JNK), an

239 on factors are released by mitogen-activated protein kinase (MAPK)-stimulated acetylation to promote

240 threonine kinase (Akt) and mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kin

241 nt allosteric inhibitor of mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kin

242 tors are phosphorylated by mitogen-activated protein kinases (MAPK) in their transactivation domains

243 apid activation of clade-A mitogen-activated protein kinases (MAPKs) MPK3 and MPK6 by wounding depend

244 n particular, we observed that AMP-activated protein kinase-mediated phosphorylation at Ser-99 promot

245 (V12) activates downstream mitogen-activated protein kinase (MEK-ERK) signaling to alter cell mechani

246 The Ser/Thr protein kinase MELK (maternal embryonic leucine zipper k

247 show that the deletion of the AMP-activated protein kinase ortholog-encoding gene SNF1 can restore t

248 and the involvement of p38 mitogen-activated protein kinase (p38) activated by neutrophil-derived oxi

249 phorylated adenosine monophosphate-activated protein kinase (pAMPK).

250 containing eukaryotic-like serine/threonine protein kinases (PASTA-eSTK) that sense PG fragments.

251 nd that alterations of the mitogen-activated protein kinase pathway (KRAS and NRAS single nucleotide

252 We show that the stress-activated protein kinase pathway (SAPK) and its effector, MAPK Sty

253 focal adhesion kinase and mitogen-activated protein kinase pathway leading to enhanced oncogenic pro

254 ar signal-regulated kinase/mitogen-activated protein kinase) pathway integrates growth-promoting sign

255 molecular functionality of PP2A-B'gamma to a protein kinase-phosphatase interaction with the defense-

256 events in the FcepsilonRI pathway, including protein kinase phosphorylation and Ca(2+) flux, were mea

257 served phosphatidylinositol 3-kinase-related protein kinases (PIKKs) target of rapamycin (TOR) has be

258 which leads to activation of cAMP-dependent protein kinase (PKA) and subsequent cardiac protein phos

259 egulated by the activities of cAMP-dependent protein kinase (PKA) and the protein phosphatase 1 (PP1)

260 ubunits (Calpha and Cbeta) of cAMP-dependent protein kinase (PKA), a pleiotropic holoenzyme that regu

261 lic adenosine monophosphate (cAMP)-dependent protein kinase (PKA), leading to activation of the PKA p

262 Type 1 cGMP-dependent protein kinases (PKGs) play important roles in human car

263 gulated by the double-stranded RNA-dependent protein kinase (PKR).

264 s that is controlled by the serine/threonine protein kinase PLK4 (refs.

265 2603 reveal a unique mode of regulation of a protein kinase, provide the first example of a bacterial

266 The role of RNA-dependent protein kinase R (PKR) and its association with misfolde

267 RIG-I)-dependent manner and readily activate protein kinase R (PKR), a known host double-stranded RNA

268 an directly bind to the innate immune sensor protein kinase R (PKR).

269 ntiviral responses dependent on the effector protein kinase R (PKR).

270 EIF2AK2 encodes a kinase (protein kinase R [PKR]) that phosphorylates eukaryotic t

271 enesis pathway, because RLBs did not require protein kinase R, phosphorylation of eukaryotic translat

272 Yet, ablation of protein kinase R-like endoplasmic reticulum kinase (PERK

273 ly, interference with the SG process using a protein kinase R-like endoplasmic reticulum kinase inhib

274 ncluding the c-Jun N-terminal kinase and the protein kinase R-like endoplasmic reticulum kinase.

275 onses to ROS and highlight the importance of protein kinase regulation through multivalent modificati

276 show in this study that receptor-interacting protein kinase (RIPK) 3 impacts pyrin inflammasome activ

277 Receptor-like protein kinases (RLKs) play key roles in regulating plan

278 lls exhibited increases in mitogen-activated protein kinase signaling and cellular metabolism, as wel

279 ain-of-function of the RAS-mitogen-activated protein kinase signaling pathway.

280 inflammatory response and mitogen-activated protein kinase signaling.

281 anscripts, including MAPK (mitogen-activated protein kinase) signaling targets, HOPX, and NPPB.

282 SnRK2.8, and the ABA-independent subclass 1 protein kinases SnRK2.1, SnRK2.4, SnRK2.5, SnRK2.9, and

283 comprises the abscisic acid (ABA)-activated protein kinases SnRK2.2, SnRK2.3, SnRK2.6, SnRK2.7, and

284 es and phosphorylates a classical eukaryotic protein kinase substrate in vitro This dual Thr-Tyr kina

285 gin and evolution of redox regulation in the protein kinase superfamily and may open new avenues for

286 m effector Lpg2603 as a remote member of the protein kinase superfamily.

287 is a divergent member of the DYRK family of protein kinases, TbDYRK.

288 rated the eSimoa method for the detection of protein kinases, telomerase, histone H3 methyltransferas

289 Target of rapamycin (TOR) is a protein kinase that coordinates metabolism with nutrient

290 ATM is a serine/threonine protein kinase that is recruited and activated by DNA do

291 re was also association with a transmembrane protein kinase that may function as a receptor for the e

292 igin activation is under control of multiple protein kinases that either promote or inhibit origin ac

293 T-LAK cell-originated protein kinase (TOPK), a serine-threonine kinase is acti

294 The dual protein kinase-transcription factor, ERK5, is an emergin

295 ibe the profiling of a non-receptor tyrosine-protein kinase (TYK2) inhibitor which shows a functional

296 Increased expression of protein kinase ULK1 was reported to negatively correlate

297 We demonstrate that this putative protein kinase undergoes autophosphorylation on Thr and

298 species and activation of mitogen-activated protein kinases upon exposure to flg22 and flgII-28.

299 The serine/threonine protein kinase v-AKT homologs (AKTs), are implicated in

300 e regulators of cell cycle such as Wee1-like protein kinase (WEE1).

301 stimulates phosphorylation of AMP-activated protein kinase, which leads to phosphorylation of the ma