ライフサイエンスコーパス: protein kinase C-delta

1 cleavage of poly(ADP-ribose) polymerase and protein kinase C delta.

2 pressing a physiologically relevant protein, protein kinase C delta.

3 and prevented by inhibitors of caspase-3 and protein kinase C delta.

4 ed expression of dominant-negative mutant of protein kinase C delta.

5 ion and Jak1 activation and was dependent on protein kinase C delta.

6 of procaspase-9, procaspase-3, gelsolin, and protein kinase C-delta.

7 mitogen-activated protein kinase kinase and protein kinase C-delta.

8 locked by rottlerin, a specific inhibitor of protein kinase C-delta.

9 r complex containing mTOR, STAT1, as well as protein kinase C delta, a known STAT1alpha kinase.

10 Our results favor protein kinase C delta activation as a mediator of norma

11 Protein kinase C delta activation increased in protein k

12 Protein kinase C delta activation is also observed durin

13 PKC (protein kinase C) delta, AKT, and SHC phosphorylation ch

14 with antisense transfections, we showed that protein kinase C delta and , but not proline-rich tyrosi

15 ROS-activated protein kinase C delta and c-jun N-terminal kinases, res

16 nked diglycerides inhibit immunoprecipitated protein kinase C delta and epsilon but not zeta activity

17 s stimulates the tyrosine phosphorylation of protein kinase C delta and inhibits its enzymatic activi

18 RCC cells in vitro through interaction with protein kinase C delta and is mediated by a specific ami

19 DAM9 and ADAM17 is associated with increased protein kinase C delta and Lyn signaling.

20 s and the antisense approach, we showed that protein kinase C delta and mediate proline-rich tyrosine

21 a binding site, involving the requirement of protein kinase C-delta and c-Src that is distinct from a

22 rmore, p38 mitogen-activated protein kinase, protein kinase C-delta, and a novel TLR2-specific signal

23 omology 2-containing inositol-5-phosphatase, protein kinase C-delta, and Erk2.

24 ly(ADP-ribose) polymerase; (iii) cleavage of protein kinase C delta; and (iv) induction of an Ac-DEVD

25 d ErbB3-binding protein 1 phosphorylation by protein kinase C delta are both required for optimal PCN

26 ck to the same position on the C1b domain of protein kinase C delta as do the phorbol esters, with th

27 We identify protein kinase C-delta as the kinase responsible for H3T

28 -induced Mvarphi polarization, and PKCdelta (protein kinase C delta) as a downstream target.

29 er vestibular nuclei were well innervated by protein kinase C delta axons and terminals.

30 Neurons expressing protein kinase C delta (BNST(PKCdelta)) are an abundant

31 hibition of intracellular calcium release or protein kinase C delta, both of which are involved in th

32 60-90-fold weaker affinity compared with the protein kinase C delta C1b domain.

33 Central amygdala neurons expressing protein kinase C-delta (CeA-PKCdelta) are sensitized fol

34 We show here that protein kinase C-delta co-localized with lamin B during

35 nger ZBDs, the interleaved RING like ZBDs of protein kinase C delta (Cys(2)HisCys and HisCys(3)), and

36 is deficient and that selective silencing of protein kinase C delta-expressing (PKCd) CEl neurons imp

37 human dendritic cells and reveal a role for Protein Kinase C-delta for enhanced Th1 cytokine product

38 Mice knocked out for the protein kinase C delta gene (PKCdelta KO) show a marked

39 tion of neurons, marked by the expression of protein kinase C-delta, in the oval region of the bed nu

40 abrogated by pretreatment of cells with the protein kinase C delta inhibitor rottlerin, but not by c

41 gents and maneuvers, such as erythropoietin, protein kinase C delta inhibitors, iron chelation, and i

42 Protein kinase C-delta is activated during apoptosis, fo

43 to PKCalpha and does not encompass the novel protein kinase C delta isoenzyme.

44 both tyrosine kinase and Ca(2+)-independent protein kinase C delta-mediated pathways involving eithe

45 C) and that this disassembly is regulated by protein kinase C delta-mediated phosphorylation of kerat

46 e, p38 mitogen-activated protein kinase, and protein kinase C delta might be involved in STAT1 phosph

47 s in response to epidermal growth factor and protein kinase C-delta overexpression, as well as PMA an

48 This effect requires the protein kinase C delta, phosphatidylinositol 3'-kinase,

49 Downregulation of protein kinase C delta (PKC delta) by treatment with the

50 LD2 also reversed increases in p21(Cip1) and protein kinase C delta (PKC delta) cleavage seen with hi

51 inhibitors were used, including rottlerin, a protein kinase C delta (PKC delta) inhibitor.

52 Protein kinase C delta (PKC delta) is tyrosine-phosphory

53 Protein kinase C delta (PKC delta) mediates apoptosis do

54 We recently demonstrated that protein kinase C delta (PKC delta) selectively regulates

55 and PI-PLC are required for translocation of protein kinase C delta (PKC delta) to the periphery of J

56 ated that Fli1 is directly phosphorylated by protein kinase C delta (PKC delta).

57 lls) become transformed by downregulation of protein kinase C delta (PKC delta).

58 llagen I expression by a mechanism involving protein kinase C delta (PKC delta): (a) PCPH knockdown i

59 Protein kinase C delta (PKC-delta) protein levels are fr

60 Protein kinase C-delta (PKC delta) plays an important ro

61 rylation of p47phox in a manner dependent on protein kinase C-delta (PKC-delta) activity.

62 This pathway required protein kinase C-delta (PKC-delta) and the guanine nucle

63 We now provide evidence that protein kinase C-delta (PKC-delta) and the p38 mitogen-a

64 PP2A co-immunoprecipitated with NKCC1 and protein kinase C-delta (PKC-delta) and was pulled down b

65 Activation of protein kinase C-delta (PKC-delta) by 12-O-tetradecanoyl

66 Protein kinase C-delta (PKC-delta) has been demonstrated

67 d activation of target genes requires active protein kinase C-delta (PKC-delta) in addition to Smads

68 In an effort to determine the role of protein kinase C-delta (PKC-delta) in cellular transform

69 To investigate the potential role of protein kinase C-delta (PKC-delta) in insulin-like growt

70 Protein kinase C-delta (PKC-delta) is a ubiquitously exp

71 Protein kinase C-delta (PKC-delta) is expressed in plate

72 Protein kinase C-delta (PKC-delta) is involved in growth

73 rosis (SSc), we have examined the effects of protein kinase C-delta (PKC-delta) on type I collagen bi

74 We have previously reported that protein kinase C-delta (PKC-delta) plays a major role in

75 Protein kinase C-delta (PKC-delta) plays a pivotal role

76 During apoptosis, activated protein kinase C-delta (PKC-delta) translocates to mitoc

77 w here that ES-62-mediated downregulation of protein kinase C-delta (PKC-delta), a TLR4-associated si

78 The overexpression of protein kinase C-delta (PKC-delta), but not PKC-epsilon,

79 Key CeA neuronal populations, including protein kinase C-delta (PKC-delta), corticotropin-releas

80 e of serine/threonine autophosphorylation of protein kinase C-delta (PKC-delta), we mutated serine 64

81 tion of GABAergic neurons that are marked by protein kinase C-delta (PKC-delta).

82 of the central amygdala (CEl), which express protein kinase C-delta (PKC-delta).

83 ow that hyperglycemia persistently activates protein kinase C-delta (PKC-delta, encoded by Prkcd) and

84 ulations in the amygdala, those that express protein kinase C delta (PKCd) and those that express som

85 males, decreases in excitability only in the protein kinase C delta (PKCd) population in males, and e

86 MARK2 itself was found to be a substrate of protein kinase C delta (PKCd), which serves as a sensor

87 gy allows the development of potential novel protein kinase C delta (PKCdelta) analogues for better t

88 ent study, we examined the novel PKC isoform protein kinase C delta (PKCdelta) and its role in vascul

89 Protein kinase C delta (PKCdelta) and p38delta are key p

90 ation of central amygdala neurons expressing protein kinase C delta (PKCdelta) as key elements of the

91 This study demonstrates that protein kinase C delta (PKCdelta) associates with SHPTP1

92 DPKCdelta cells in response to activation of protein kinase C delta (PKCdelta) by phorbol 12-myristat

93 ine whether testosterone (T) alters coronary protein kinase C delta (PKCdelta) expression and whether

94 Ang II caused activation of protein kinase C delta (PKCdelta) in C9 cells, and its s

95 In this study, we investigated the role of protein kinase C delta (PKCdelta) in K-ras-dependent lun

96 n known to cause tyrosine phosphorylation of protein kinase C delta (PKCdelta) in platelets, but the

97 We also found that protein kinase C delta (PKCdelta) inhibits GAPDH-driven

98 previously shown that the novel PKC isoform protein kinase C delta (PKCdelta) is activated by TGFbet

99 In this study the potential role of protein kinase C delta (PKCdelta) on meiotic spindle org

100 The inhibitors for protein kinase C delta (PKCdelta) or extracellular signa

101 Protein kinase C delta (PKCdelta) plays a role in mediat

102 Protein kinase C delta (PKCdelta) regulates apoptosis in

103 Overexpression of protein kinase C delta (PKCdelta) stimulates apoptosis i

104 Inhibition of protein kinase C delta (PKCdelta) with rottlerin or siRN

105 Protein kinase C delta (PKCdelta), a Ca(2+)-independent,

106 ence (false discovery rate < .10), including protein kinase C delta (PKCdelta), a CeL microcircuit ce

107 We report that protein kinase C delta (PKCdelta), a serine/threonine ki

108 of PAI-1 via sequential activation of c-Src, protein kinase C delta (PKCdelta), and sphingosine kinas

109 cells, this adaptive response is mediated by protein kinase C delta (PKCdelta), but the mechanisms by

110 We have identified a key signaling kinase, protein kinase C delta (PKCdelta), whose alternative spl

111 -CUB-domain containing protein 1 (CDCP1) and protein kinase C delta (PKCdelta)-in 56 formalin-fixed,

112 te that c-Abl associates constitutively with protein kinase C delta (PKCdelta).

113 MNL1beta to the IS, which was independent of protein kinase C delta (PKCdelta).

114 pendent or -independent for co-dependency on protein kinase C delta (PKCdelta).

115 we show that phorbol esters, acting through protein kinase C-delta (PKCdelta) and mitogen-activated

116 Previously, we identified protein kinase C-delta (PKCdelta) as an important regula

117 Protein kinase C-delta (PKCdelta) has been shown to be u

118 The diverse roles of protein kinase C-delta (PKCdelta) in cellular growth, su

119 mplicated activation of NF-kappaB as well as protein kinase C-delta (PKCdelta) in neutrophil apoptosi

120 Protein kinase C-delta (PKCdelta) is a key regulator of

121 Protein kinase C-delta (PKCdelta) is a Ser/Thr kinase th

122 Protein kinase C-delta (PKCdelta) is an allosterically a

123 Recently, we demonstrated that protein kinase C-delta (PKCdelta) is an oxidative stress

124 by both Ro-32-0432 and rotterlin, suggesting protein kinase C-delta (PKCdelta) may play a role in TGF

125 results in the caspase-dependent cleavage of protein kinase C-delta (PKCdelta) to a 40-kDa fragment,

126 amine also rapidly and transiently activates protein kinase C-delta (PKCdelta), extracellular signal-

127 connectivity, and functional contribution of Protein Kinase C-delta (PKCdelta)-expressing neurons in

128 Moreover, inhibition of protein kinase C-delta prevented DUSP4 expression declin

129 ctivation of focal adhesion kinase 1 (FAK1), protein kinase C-delta (PRKCD), and Ephrin (EPH) family

130 nuated dieldrin-induced histone acetylation, Protein kinase C delta proteolytic activation and DNA fr

131 have previously demonstrated that PKCdelta (protein kinase C-delta) regulates multiple components of

132 Protein kinase C delta showed significant translocation

133 The differential impact of a protein kinase C-delta TAT peptide inhibitor (PKCdelta-i

134 ctivation of Akt, PIP3-dependent kinase, and protein kinase C delta was defective.

135 rtantly, chemical inhibition or knockdown of protein kinase C delta was sufficient to rescue the phen

136 With the antibody to protein kinase C delta, we found scattered, weakly immun

137 hat some substrates (for example, c-Cbl, and protein kinase C delta) were Src family substrates where

138 were specifically sensitive to inhibition of protein kinase C delta, which was further confirmed by t

139 ifferentiation mediated by overexpression of protein kinase C, delta, which is a direct target of HDA

140 ld not be restored by the addition of ATP or protein kinase C delta with ATP, suggesting that dietary

141 Also, H(2)O(2) induced the association of protein kinase C-delta with the platelet-derived growth