ライフサイエンスコーパス: protein translation

1 creased 18S and 28S rRNA levels and elevated protein translation.

2 s virus production by preventing shutdown of protein translation.

3 induces host protein degradation and blocks protein translation.

4 te transfer RNAs in a critical early step of protein translation.

5 cellular tasks, like mRNA transcription and protein translation.

6 ) are associated in defined complexes during protein translation.

7 echanism involved in energy homeostasis, and protein translation.

8 c initiation factor 2alpha to inhibit global protein translation.

9 rial energy production and the regulation of protein translation.

10 have been shown to have a negative effect on protein translation.

11 ons show loss-of-function effects and impair protein translation.

12 mycin (mTOR) pathway component that inhibits protein translation.

13 IF2S1 or EIF2A), which affects regulation of protein translation.

14 l insights into the regulatory mechanisms of protein translation.

15 he homologous region of ZEB1 does not affect protein translation.

16 ional modification that appears to influence protein translation.

17 acy and nutrient starvation responses during protein translation.

18 ecules, which is the essential first step of protein translation.

19 ease of functional mRNA and highly efficient protein translation.

20 d function by regulating gene expression and protein translation.

21 cted signaling pathway, leading to increased protein translation.

22 eased by C3P3, suggesting a direct effect on protein translation.

23 -RNA incorporation, in addition to enhancing protein translation.

24 mic signaling pathways that control neuronal protein translation.

25 tion is important for cell motility by local protein translation.

26 t overproduction of transcripts required for protein translation.

27 nsport, metabolism, protein trafficking, and protein translation.

28 is an acetyltransferase toxin that inhibits protein translation.

29 ithin viral inclusions, which did not impair protein translation.

30 t transcriptional processes to support viral protein translation.

31 degradation of target mRNAs or inhibition of protein translation.

32 of translation factors to mRNA, and blocked protein translation.

33 ontrol for VEGF-D expression at the level of protein translation.

34 icroRNAs (miRNAs)--block gene expression and protein translation.

35 ces the fraction of viral genomes engaged in protein translation.

36 d 5'-untranslated region predicted to impair protein translation.

37 of SLC4A4 and CFTR mRNAs, thereby inhibiting protein translation.

38 anslocated proteins that interfere with host protein translation.

39 s a protein kinase involved in regulation of protein translation.

40 to be associated with reduced cap-dependent protein translation.

41 I and suppresses SidI-mediated inhibition of protein translation.

42 a uniquely selective reduction of cytosolic protein translation.

43 mpared with IL-5 and GM-CSF, with a focus on protein translation.

44 radation of misfolded proteins, and reducing protein translation.

45 and defects in both ribosome biogenesis and protein translation.

46 an aminoacyl-tRNA transferase needed during protein translation.

47 hrough ribosomal S6 kinase (RSK) and enhance protein translation.

48 tRNA molecules, the essential first step of protein translation.

49 bophagy activity to both nutrient supply and protein translation.

50 d cellular distribution of the machinery for protein translation.

51 , DIMT1-E85A could not revert the defects in protein translation.

52 n at multiple levels, including splicing and protein translation.

53 control the speed and hence the fidelity of protein translation.

54 ns, with the largest group being involved in protein translation.

55 ting T cell activation, gene expression, and protein translation.

56 hijacked host biosynthesis pathways through protein translation.

57 thesis, as activated 4E-BP1 represses global protein translation.

58 IIa family of tRNA synthetases required for protein translation.

59 ss granules (SG) and is postulated to affect protein translation.

60 ion initiation factors that dampens synaptic protein translation.

61 e, leads to an upregulation of Cap-dependent protein translation.

62 assham cycle, carbon storage metabolism, and protein translation.

63 proteins as well as factors that function in protein translation.

64 proving protein quality control is to reduce protein translation.

65 gene-specific molecules designed to inhibit protein translation.

66 accurately charges leucine to tRNA(Leu) for protein translation.

67 re normally associated with RNA turnover and protein translation.

68 s ranging from control of gene expression to protein translation.

69 is a key variable that sets the magnitude of protein translation.

70 activation of AMPK signaling and the rate of protein translation.

71 cyl-tRNA synthetases (ARSs) are critical for protein translation.

72 xpression by altering mRNA levels and tuning protein translation.

73 uORFs) are tissue-specific cis-regulators of protein translation.

74 spindle-assembly competent in the absence of protein translation.

75 a number of nucleosides in rRNA and promote protein translation.

76 gnate tRNA molecules, which are required for protein translation.

77 for the last step in gene expression, namely protein translation.

78 Because OCTR-1 downregulates protein translation activities, the OCTR-1 pathway could

79 that this tRNA complement could restore the protein translation activity of tRNA-depleted E. coli ly

80 aminergic neurodegeneration via dysregulated protein translation, although how alterations in protein

81 /iodide symporter (NIS), leading to impaired protein translation and a subsequent reduction in iodide

82 We also observed higher basal protein translation and an absence of DHPG-induced incre

83 ity and mechanical allodynia require de novo protein translation and are mediated by TRPV1 and oxidat

84 ct from those in R6/2 and primarily involved protein translation and bioenergetics pathways.

85 an alternative way for understanding altered protein translation and brain circuit excitability assoc

86 ation and consequently led to increased JNK2 protein translation and c-Jun activation.

87 injury whereas the lumbar profile represents protein translation and cytokine signaling.

88 s) in association with neuronal development, protein translation and cytoplasm transportation.

89 w measurement of protein dynamics, including protein translation and degradation.

90 reasing or decreasing mRNA expression and/or protein translation and degradation.

91 evels and identify a regulatory link between protein translation and DNA replication.

92 d synaptic scaling, a process which required protein translation and eukaryotic elongation factor-2 k

93 se studies is the intimate interplay between protein translation and folding, and within this the rib

94 de highly sensitive and specific markers for protein translation and genome replication.

95 ion, thus establishing a direct link between protein translation and HSF1 activity.

96 unction (i.e. increased frameshifting during protein translation and hypersensitivity toward the eEF2

97 eostasis in two ways: MLII mice downregulate protein translation and increase the integrated stress r

98 t elevating neural network activity requires protein translation and is dependent on fragile X mental

99 esidue, diphthamide, at His715, which blocks protein translation and leads to cell death.

100 s-induced activation of dHSCs by restricting protein translation and levels of reactive oxygen specie

101 BCKAs increased protein translation and mTORC1 activation.

102 echanism by which Gp1 mGluR and FMRP mediate protein translation and neural network activity, potenti

103 termine the mechanism by which FMRP mediates protein translation and neural network activity, we demo

104 l mechanism through which Gp1 mGluR mediates protein translation and neural plasticity.

105 e approach to study how the cell coordinates protein translation and nitrogen assimilation to optimiz

106 ology, driving fundamental processes such as protein translation and participating in the regulation

107 ant cancer cell lines converged on ribosomal protein translation and proteasomal protein degradation

108 events +1 errors in the reading frame during protein translation and represents an attractive potenti

109 ry and identified 126 proteins, enriched for protein translation and RNA metabolism pathways, which c

110 icated that IRF5 re-expression inhibited HCV protein translation and RNA replication.

111 sphorylation of eIF2alpha to diminish global protein translation and selectively allow for the synthe

112 (betaTrCP) and miR-21 to suppression of SKP2 protein translation and stability.

113 that interact with ezrin were implicated in protein translation and stress granule dynamics.

114 e catalytic activity of DIMT1 is involved in protein translation and that the overall protein scaffol

115 'reader' YTHDF1, targets a gene involving in protein translation and thus affects overall protein pro

116 ethylates Cap-0 viral mRNAs to improve viral protein translation and to avoid host immune detection.

117 gh dynamic control of glucose uptake, global protein translation and transcriptional regulation.

118 replication proceeds normally through early protein translation and uncoating but stalls at replicat

119 same genome browser, along with gene models, protein translation and variation tracks.

120 How FMRP impacts synaptic protein translation and which mRNAs are most important f

121 on of Dgkkappa, indirectly controls synaptic proteins translation and membrane properties by impactin

122 mTORC1 mediates ribosome biogenesis, protein translation, and autophagy, whereas mTORC2 contr

123 on, rDNA transcription, ribosome biogenesis, protein translation, and cell growth.

124 ns of capping are to promote mRNA stability, protein translation, and concealment from cellular prote

125 er-protein interactions, mRNA transcription, protein translation, and decay, we prove that in the lim

126 kinases was toxic to PMBL cells, attenuated protein translation, and down-regulated NF-kappaB- and S

127 onal mutations affecting JAK/STAT signaling, protein translation, and epigenetic control, providing n

128 have altered presynaptic function, enhanced protein translation, and increased levels of F-actin.

129 phosphate (dTMP) biosynthesis, mitochondrial protein translation, and methionine regeneration.

130 mTORC1 is critically involved in RNA-to-protein translation, and we found that the first alcohol

131 uple environmental cues to the regulation of protein translation are not well understood.

132 rticular interest as members function during protein translation, are essential for viability, and ar

133 t biological processes, including regulating protein translation, Argonaute-dependent gene silencing,

134 osomal subunit joining and attenuated global protein translation as a consequence of defective eIF6 e

135 eIF2A-phosphorylation-mediated inhibition of protein translation as a critical mediator of the antile

136 kt/p70S6K/S6 axis activation, and HIF-1alpha protein translation, as well as malignant transformation

137 In vitro ADP-ribosylation and protein translation assays demonstrate that the resultin

138 Here, we show that TGFbeta promotes protein translation at least in part by increasing the m

139 disease-relevant signals affect chondrocyte protein translation at the transcriptomic level has not

140 Nutritional restriction leads to protein translation attenuation that results in the stor

141 ncluding cell proliferation, RNA processing, protein translation, autophagy, apoptosis and antiviral

142 PIM inhibition decreased cap-dependent protein translation, blocked JAK-STAT signaling, and mar

143 ies not only suggest that Gib2 has a role in protein translation but also present Gib2 as a physical

144 NSVs completely rely on the host cell for protein translation, but their codon usage bias is often

145 the adult CNS through suppression of myelin protein translation by activating PERK.SIGNIFICANCE STAT

146 actor eEF1A and potently inhibits eukaryotic protein translation by an unknown mechanism.

147 mechanisms in CR, we assayed rhythms in the protein translation by analyzing polysome-associated mRN

148 RNAs) are small noncoding RNAs that regulate protein translation by binding to complementary target m

149 se findings we propose that p190A may affect protein translation by controlling the assembly of funct

150 applicable strategy for robustly controlling protein translation by integrating synthetic translation

151 equences (SD) in prokaryotic mRNA facilitate protein translation by pairing with rRNA in ribosomes.

152 Active protein translation can be assessed and measured using r

153 overexpression of 4E-BP1, a key repressor of protein translation, can protect against misfolded prote

154 RNA maturation, is critical for chondrocyte protein translation capacity in osteoarthritis.

155 y active niche signaling integration and low protein translation capacity.

156 about 7 to 16% on the fraction of cytosolic protein translation carried out by ribosomes accessible

157 rthermore, knockdown of these genes impaired protein translation, caused endoplasmic reticulum stress

158 r mitoribosome assembly impair mitochondrial protein translation, causing combined OXPHOS enzyme defi

159 f Rapamycin Complex 1 (mTORC1), reduction of protein translation, cell cycle arrest, and conservation

160 tochondrial dynamics, nucleoid organization, protein translation, cell growth, and cholesterol metabo

161 pathway in promoting morphine-induced spinal protein translation changes and associated morphine tole

162 s, epigenetic or transcriptional regulation, protein translation, circadian disruption, and interacti

163 ontroversial, growing evidence suggests that protein translation control may play a crucial role.

164 NPs by 6 different routes and high levels of protein translation could be measured using in vivo imag

165 ses of PEAK1-depleted PDAC cells, we defined protein translation, cytoskeleton organization, and cell

166 ity, has revolutionized our understanding of protein translation dynamics.

167 ein synthesis was associated with diminished protein translation efficiency but, surprisingly, not wi

168 Data revealed that inhibition of protein translation eliminated the mGluR1-mediated inhib

169 res its binding to an essential housekeeping protein, translation elongation factor Tu (EF-Tu).

170 lar functions, including genome maintenance, protein translation, energy conversion, and the antivira

171 led ribosomal fractions identified ribosomal proteins, translation factors and RNA-binding proteins (

172 es in cells and identified several ribosomal proteins, translation factors, and mRNAs.

173 2) Bcl-2 PPI analyses by imaging fluorescent protein translation from mRNA outputs.

174 gulatory process that determines the rate of protein translation from mRNA.

175 at in addition to the production of the A2AR protein, translation from an upstream, out-of-frame AUG

176 m of cellular defense involving de novo NRF2 protein translation governed by the EF1a interaction wit

177 an RNA-binding protein that regulates local protein translation, has been shown to be enriched in NL

178 By preventing protein translation, HNP1 functions as a "molecular brak

179 ate that pools of transfer RNA available for protein translation impact on the configuration of epith

180 ted neurons by facilitating viral structural protein translation.IMPORTANCE Mosquito-borne alphavirus

181 enic mice and confirmed marked reductions in protein translation in 4E-BP1-overexpressing primary neu

182 egulation of vimentin mRNA transcription and protein translation in a dose-dependent manner.

183 S) in the 5'UTR of p53 mRNA and enhanced p53 protein translation in a methyltransferase-independent m

184 re, we present the first genome-wide view of protein translation in an IgG-producing CHO cell line, m

185 re used to study intracellular signaling and protein translation in cells activated with IL-3, GM-CSF

186 the UPR functions as the master regulator of protein translation in ER-stressed cells.

187 how that SQRD-1 is also required to maintain protein translation in H2S.

188 role in the regulation of AMPK signaling and protein translation in neural stem cells and its associa

189 quirement for ribosomal frameshifting during protein translation in order to produce the polyprotein

190 ies, the innate immune system down-regulates protein translation in response to viral infection throu

191 moters to upregulate genes involved in local protein translation in synaptic compartments.

192 te how the axonal miR-26a can regulate local protein translation in the axon to facilitate retrograde

193 nthetic Escherichia coli tRNAs could support protein translation in the cell-free system.

194 nterleukin 1-beta (IL-1beta) rapidly affects protein translation in the chondrocytic cell line SW1353

195 ght to kill Plasmodium parasites by blocking protein translation in the essential apicoplast organell

196 Adaptive changes in protein translation in the nervous system are thought to

197 memory consolidation by impairing requisite protein translation in the VHIPP.

198 or-mediated calcium signaling and peripheral protein translation in the weakly IB4-binding population

199 the global impact of iron, heme, and HRI on protein translation in vivo in murine primary erythrobla

200 In this study, we investigate protein translation in zebrafish models of CdLS.

201 OR-mediated calcium signaling and peripheral protein translation, in the weakly IB4-binding populatio

202 Inhibitors of PKD, Gbetagamma, and protein translation inhibited recovery of PAR(2) respons

203 support a role for anti-NOTCH1 therapies and protein translation inhibitor combinations in the treatm

204 The protein translation inhibitor cordycepin, injected at th

205 intrathecal administration of cordycepin, a protein translation inhibitor that reverses priming.

206 -bromo cAMP; (4) failure to be reversed by a protein translation inhibitor; (5) priming in females as

207 Overall, this study provides evidence of protein translation initiation at noncanonical TISs and

208 mechanism involving EIF3C, a subunit of the protein translation initiation factor EIF3, as the direc

209 ntiviral protein that inhibits cap-dependent protein translation initiation via phosphorylation of eI

210 , including mRNA-binding proteins, ribosomal proteins, translation initiation factors and translation

211 Dysregulation of protein translation is a key driver for the pathogenesis

212 f a signaling pathway that is activated when protein translation is compromised.

213 Localized protein translation is critical in many biological conte

214 Regulation of protein translation is crucial for normal stem cells and

215 However, since protein translation is energetically expensive and tight

216 Protein translation is essential for cell physiology, an

217 Protein translation is inhibited by the unfolded protein

218 Protein translation is initiated with methionine in euka

219 In contrast, global protein translation is not altered in wild-type animals

220 The function of UTRs in protein translation is well established.

221 is normally considered a protein involved in protein translation, is a morphogenic protein.

222 In addition, to detect any changes in protein translation levels as a result of Xa21 gene expr

223 ble to phage display that would overcome the protein translation limitations of microorganisms.

224 factors necessary for making ribosomes, the protein translation machinery in the cell.

225 The protein translation machinery of the host cell is curren

226 ous transmission signals to the postsynaptic protein translation machinery through Ca(2+)-induced Ca(

227 nd that "off- and reloading" distributes the protein translation machinery.

228 hock response, accompanied by attenuation of protein translation, massive protein aggregation, growth

229 ed phenotypes, (2) deregulated EIF2-mediated protein translation may represent a mechanism for vulner

230 Our results demonstrate that impaired protein translation mediated by poly-PR and poly-GR pept

231 is and identify the global shutdown of renal protein translation mediated by the eukaryotic translati

232 nt temperature triggers metabolic changes in protein translation, mitochondrial protein synthesis, an

233 Protein translation, mitochondrial respiratory chain com

234 n-like growth factor-1, dietary restriction, protein translation, mitochondrial signaling) in a longi

235 wed elevated expression of the mitochondrial protein translation (MPT) gene pathway relative to tumor

236 mall GTPase and an associated local synaptic protein translation network in this process.

237 some have been instrumental in understanding protein translation, no such probes exist to study ribos

238 e find that glutamate treatments up-regulate protein translation not only in intact rat cortical neur

239 mycin complex 1 by Akt resulted in increased protein translation of DNMT3a.

240 yltransferase function of EZH2 that controls protein translation of p53 GOF mutants, inhibition of wh

241 creasing RNA destabilization and inefficient protein translation of the viral Mecp2 transgene, limits

242 which serves as a regulatory switch to turn protein translation on or off.

243 addition, we found additional inhibition of protein translation owing to diminished mTORC1 (mammalia

244 rface signalling, cell-cell interaction, and protein translation (p < 0.01).

245 x and ER homeostasis, which is essential for protein translation, pancreatic function, and cellular a

246 xidative phosphorylation-related metabolism, protein translation processes, and phospho-signaling mod

247 nt alterations in cell cycle, metabolic, and protein translation processes.

248 Cells dynamically adjust their protein translation profile to maintain homeostasis in c

249 s mRNA stability, sub-cellular localization, protein translation, protein binding and translation eff

250 eoformans was associated with alterations in protein translation rate and activation of several stres

251 NA fragments in the absence of NSun2 reduces protein translation rates and activates stress pathways

252 ellular variations in mRNA transcription and protein translation rates attributed to cell-to-cell dif

253 Protein translation rates serve as the integrator that p

254 ome regulates the efficiency and fidelity of protein translation rates.

255 m, fatty acid and mycolic acid biosynthesis, protein translation, redox regulation and detoxification

256 cription regulation and mGluR5/FMRP-mediated protein translation regulation through coregulation of a

257 model where age-dependent down-regulation of protein translation-related components contributes to ex

258 (translation initiation factor eIF4E-binding protein) translation repressor protein Caf20, and the Go

259 ifying genome-wide levels of mRNA and active protein translation, respectively, we analyzed the respo

260 Finally, the inhibitor of protein translation reversed hyperalgesic priming only w

261 hat glutamine is both an energy source and a protein-translation rheostat that is responsive to WNT a

262 e, an antibiotic that inhibits mitochondrial protein translation, selectively eradicates CML LSCs bot

263 physiological and pathological processes of protein translation, signal transduction, immunity, lung

264 nd that 4E-BP1, a repressor of cap-dependent protein translation, specifically regulates the level of

265 mmon inherited mutation located close to the protein translation start site that is thought to produc

266 ities after the entry process, likely at the protein translation step of WNV replication.

267 Antisense inhibition of WT1 protein translation strongly reduced Aoc1 transcripts in

268 many associated with ribosomal synthesis and protein translation, suggesting the importance of protei

269 m mammalian cells, bacteria, and a cell-free protein translation system, we show that the SARM1-TIR d

270 pamycin (mTOR) signaling, causing a shift in protein translation that enhanced the expression levels

271 on the development of a stochastic model for protein translation that is capable of simulating the dy

272 of riboswitches regulates the initiation of protein translation, the fate of whether an RNA message

273 Protein translation through eukaryotic initiation factor

274 plays a distinct role in controlling L1 ORF2 protein translation through L1 mRNA binding.

275 PI-3K signaling is known to regulate protein translation through mTORC1-dependent phosphoryla

276 Expression of the DB7 fusion gene may reduce protein translation to impair brain functions and thereb

277 tissue and mediates a protective shift from protein translation to NMD-dependent mRNA degradation.

278 asmic reticulum (ER) stress, cells attenuate protein translation to prevent accumulation of unfolded

279 mmunosurveillance exploits natural errors in protein translation to provide antiviral immunity.

280 ie restriction reprograms diurnal rhythms in protein translation to regulate metabolism.

281 induces oxidative stress and interferes with protein translation, to ATRA sharply increases APL cell

282 Protein translation typically begins with the recruitmen

283 hypoxia-inducible factor-1alpha (HIF-1alpha) protein translation upregulation, in turn resulting in m

284 novel working model of strong inhibition of protein translation via interactions of G4 with potentia

285 variety of cellular conditions and regulates protein translation via phosphorylation of the translati

286 ed a novel function of p50 in modulating p53 protein translation via regulation of the miR-190/PHLPP1

287 DEBS1, substantial premature termination of protein translation was observed.

288 Moreover, HIF-1alpha protein translation was upregulated via activating the A

289 rget of rapamycin (mTOR), which governs most protein translation, was activated in rat spinal dorsal

290 glutamate receptor (GpI mGluR) signaling to protein translation, we find that GpI mGluR stimulation

291 anges to genes related to AMPK signaling and protein translation were confirmed using reverse transcr

292 Transcriptional changes implicated in protein translation were observed in knockdown hNPCs, an

293 ribosome biogenesis is reflected in reduced protein translation, which is inversely correlated with

294 ed S6K and 4EBP1 phosphorylation to decrease protein translation, which slowed down cell growth and p

295 R) and reflected ARF-dependent impairment of protein translation, which was exaggerated by drug treat

296 y highlights a novel regulatory mechanism of protein translation with AUUUA motifs in the 3' UTR of m

297 Growing cells coordinate protein translation with metabolic rates.

298 Inhibiting protein translation with puromycin blocks miR-122-mediat

299 ow that HNP1 enters macrophages and inhibits protein translation without inducing the unfolded-protei

300 nd ribosome assembly, mRNA transcription and protein translation without intact cells.