ライフサイエンスコーパス: protonate

1 up as the network histidine residues become protonated.

2 100-200 ns before the proton-loading site is protonated.

3 ated, whereas plastoquinone B is reduced and protonated.

4 tion (~1%), is only accessible when GLUex is protonated.

5 his ground-state photo-intermediate as being protonated.

6 dic environments in which C-termini are also protonated.

7 The addition of HONO (8) to protonated 1-phenylpropyne (18) is calculated to follow

8 Acetonitrile is trimerized to generate protonated 2,4,6-trimethyl-s-triazine tautomers in situ,

9 iginates from a 1,2-alkyl rearrangement of a protonated 3,3'-spiroindolenine was isolated and charact

10 arge states around 27+, all the way to fully protonated (33+) aMb.

11 Calculated electronic absorptions for the protonated (356 nm) and neutral species (440 nm) are in

12 In particular, the crystals of protonated 4 + 2 + 2 macrocyclic amine, which contains t

13 situation was observed for a multiply folded protonated 8 + 8 macrocycle which binds six sulfate anio

14 molog, but by proton return from the earlier protonated acceptor, preventing vectorial proton translo

15 e via AQP9 than given by the fraction of the protonated acid substrate at a certain pH.

16 arkable resistance to oxidation and powerful protonating acids, and freeze yarn untwist.

17 he oxido ligand that aids in stabilizing the protonated adduct.

18 (H(+))(aq), often considered to be the major protonating agent there.

19 parameters such as solvent, temperature, or protonating agent were examined as well as protecting gr

20 otonation step, leading to the liberation of protonated alkene products.

21 w strategy that involves the use of chiral N-protonated alkenyl oxazaborolidines as dieneophiles.

22 nplanar bridged lactams to directly access N-protonated amide bonds, (2) validates the use of the add

23 Transformation of the dyes into protonated amidinium salts leads to narrower band gaps a

24 electrophile is activated by the catalyst's protonated amine and that the nucleophile binds to the t

25 ollowed as protonated species (CI)H(+) using protonated amines as reagent ions.

26 cleavage of H2, Mo hydride complexes bearing protonated amines, [CpMo(H)(CO)(P2N2H)](+), were charact

27 The protonated amino moiety forms a persistent salt bridge w

28 C-S bond formation and instead suggest that protonated aminomethyl functions as an electron-withdraw

29 resent an algorithm based on the sodiated to protonated/ammoniated adduct ion ratios of applied inter

30 intrinsic helix hairpin, the lumenal channel protonates an acidic glutamate in the c-ring rotor.

31 s did not take into account fragmentation of protonated analyte molecules, which introduced a small b

32 Only protonated analytes with a carboxylic acid, a sulfone, o

33 ied solvent additives favor the formation of protonated and ammoniated ions in positive ion mode, yet

34 Under acidic conditions, when His(12) is protonated and charged, the GWALP23-H12 helix exhibits a

35 were obtained and characterized by UV-vis in protonated and deprotonated forms by reduction of previo

36 Ci1 retains a pK(a) of 7.6 so that both its protonated and deprotonated forms equilibrate at physiol

37 trates a promising method to distinguish the protonated and deprotonated ions of metabolites from the

38 n from PFOA, we investigated reactions using protonated and deprotonated species of PFOA and SO(4)(*-

39 ional energies of all analogues, in both the protonated and deprotonated species, were explored by us

40 An isotopologue approach using both protonated and deuterated 4,4'-bipyridine molecules demo

41 of 3 K is observed at 262 K or 257 K in the protonated and deuterated materials, respectively.

42 g finding is that the central carbon becomes protonated and has to move out of the cavity as a methyl

43 r histidines with two of the four histidines protonated and if other titratable amino acid residues i

44 Phase transfer occurs by dynamic assembly of protonated and neutral amides with [AuCl4 ](-) ions thro

45 ase transition in polycrystalline samples of protonated and partially deuterated [FeL(2) ][BF(4) ](2)

46 charged thiolate state and His(41) is doubly protonated and positively charged, instead of the neutra

47 At physiological pH, E623 is un-protonated and TMEM16A is activated when intracellular c

48 GFP-like protein LEA, involving semi-trapped protonated and trapped deprotonated chromophores en rout

49 , an entropically favored form with tyrosine protonated and unbound from the Cu(II) site, and an enth

50 vestigated, and Raman bands belonging to the protonated and unprotonated forms of the isoquinoline ri

51 r, under acidic conditions E623 is partially protonated and works synergistically with intracellular

52 rotonation), low pH (acidic residues and His protonated), and highly acidic environments in which C-t

53 th without nuclear quantum effects and for a protonated Arg52.

54 pically substituted ((15)N, (13)C, and (2)H) protonated arginine isotopologues.

55 M triflic acid/dichloroethane, anthracene is protonated at C9, and the resulting 9-anthracenium ion i

56 and computational studies show that [H1](+) protonates at sulfur.

57 cyclohexadienes: In solution, it selectively protonates at the ortho position, and the resulting eta(

58 -transfer reactions involving highly acidic, protonated atmospheric molecules, such as nitrogen and w

59 Although protonated azulitriphyrins(1.2.1) proved to be very stab

60 icities (GB, DeltaG for deprotonation of the protonated base) and proton affinities (PA, DeltaH for d

61 inities (PA, DeltaH for deprotonation of the protonated base) of six lipids representing common phosp

62 e the ability of intact CA to quantitatively protonate bases with biologically-relevant pK(a)s and ar

63 erimental studies using two UCST-type TRILs, protonated betaine bis(trifluoromethyl sulfonyl)imide ([

64 contain both mononuclear [MOH](+) and double protonated binuclear metal clusters [M(mu-OH)(2)M](2+) (

65 function is especially induced by the double protonated binuclear species.

66 decarboxylation the enolate intermediate is protonated by a histidine preventing CO(2)-enolate recom

67 Compound 3 is readily protonated by tBuOH to induce a ring-opening sigma-bond

68 imensional structure of cryogenically cooled protonated C-terminally methyl esterified leucine enkeph

69 Here, we examine a variety of protonated carbohydrate structures by gas-phase hydrogen

70 analysis also revealed the absence of other protonated carbon-containing components that would affec

71 the measurement of isotopic fractionation of protonated carbons at natural abundance.

72 Helix stabilization requires the protonated carboxyl group; unexpectedly, this stabilizat

73 yl radicals have been observed both in their protonated cation form and in their unprotonated neutral

74 and prevent energy transfer, a bulky singly protonated cation that avoids H-bonding is ideal.

75 pending on the counterion, O-protonated or N-protonated cations can be formed, in accord with theoret

76 excited-state proton transfer (ESPT) of the protonated chromophore, we infer design principles of th

77 through interaction or entrapment of the non-protonated, circular helical (blue) structure of phycocy

78 A bridge-protonated Co(I) species was ruled out as a catalytic in

79 +)) prior to C-C bond breaking would produce protonated CO2, an energetically inaccessible species th

80 ng as that would lead to formation of doubly protonated CO2.

81 The subsequent barriers of protonating *CO2(delta-) to form COOH* and then dissocia

82 Importantly, we reveal a novel protonated compound of HSrRuO(3) with paramagnetic metal

83 version between a metal-hydride and a ligand-protonated congener using an exogeneous ligand introduce

84 ) in barrier lowering) when the catalyst was protonated, consistent with electrostatic stabilization

85 Thus, it is demonstrated that protonated cyclohexanol dimers dehydrate without the for

86 The role of protonated cyclopropane (PCP(+)) structures in carbocati

87 Triply protonated cyclotide cations are transformed into radica

88 more stable; both parallel and antiparallel protonated d(GA+A).d(GAA):d(TTC) triplexes are stable.

89 of aspartate, due to a hydrogen-bond between protonated D46 and a catalytic cysteine residue.

90 en metal-ion-bound O(2) and its reduced (and protonated) derivatives is critically important for a fu

91 graphic data and DFT calculations support a "protonated diborene" structure for this compound, which

92 Addition of TFA afforded a C-protonated dication with a significantly increased diatr

93 tion of monocations, and the generation of C-protonated dications was no longer favored due to the pr

94 nts, and under strongly acidic conditions, C-protonated dications were generated with substantial dia

95 In the presence of cyclohexanol, its protonated dimers at Bronsted acid sites hinder the adso

96 is substituted with an electron withdrawing protonated dimethylamino group at the para position, hyd

97 significant bathochromic shifts observed for protonated dithia-bis(calix)-sapphyrins macrocycles.

98 However, the protonated dithia-bis(calix)-sapphyrins showed large bat

99 e report that the gas-phase fragmentation of protonated dityrosine cross-linked peptides under ultrav

100 ects of the cationic Bronsted acid part (the protonated DMAP) in the presence of chloride binding Sch

101 sed as a switchable solvent and converted to protonated DMBA form by the addition of dry ice.

102 r, the intensity of m/z 154 corresponding to protonated dopamine was monitored before and after elect

103 Evidence of the protonated dpat ligand in 1 and 2 was found through isol

104 for a closed conformation in situations with protonated E286.

105 s oligomerization, demonstrating the role of protonated E73 in enhancing dimer formation.

106 We demonstrate that protonated electron-poor O-aryl hydroxylamines give amin

107 )ethane), to a highly reactive, S = 1/2 ring-protonated endo-Cp*H-Fe relative, triggered by the addit

108 t CI, CH2OO, is detectable as an adduct with protonated ethers, preferably with protonated tetrahydro

109 When Sx binds a Cl(-), the protonated Ex moves upward, out of the positive helix ca

110 ution despite a much shorter lifetime of the protonated excited-state complex.

111 hematite is associated with coupled O-Fe and protonated Fe vacancies, providing a potential link betw

112 in pH, which was related to the reaction of protonated Fe(VI) species (HFeO(4)(-)) with MNV.

113 he facile reactivity profiles of early stage protonated Fe-N2 and Fe-CN species.

114 a) is due to Glu325 (helix X), which must be protonated for LacY to bind galactoside effectively.

115 Superoxide radicals (O2( *-)) and their protonated form (hydroperoxyl radicals, HO2( *)) were de

116 a pre-reactive complex SETD3 binds the N(3)-protonated form (N(3)-H) of actin His73, and in a post-r

117 Importantly, the protonated form 1a.H(+) provokes a specific staining of

118 helical C2-symmetric structure and that its protonated form is the thermodynamic product of the Frie

119 -catalyzed base excision that features an N3-protonated form of caC but would be ineffective for C, m

120 , which corresponds to its reaction with the protonated form of the substrate.

121 Single crystal X-ray analysis of the protonated form reveals a structure consisting of a hydr

122 d to wild-type VAO, but predominantly in its protonated form when bound to the variants.

123 we studied the entrance of O(2) (*-) and its protonated form, perhydroxyl radical [(HO(2) (*)); pK(a)

124 on-exchange Donnan exclusion membrane in its protonated form.

125 l hydrogen bond hinders the oxidation of the protonated form.

126 entation of the oxygen-bound hydrogen in its protonated form.

127 In nitrogen, protonated forms of dimethyl methyl phosphonate (DMMP) a

128 ear-infrared (NIR) absorption in neutral and protonated forms of macrocycles is the important highlig

129 e Escherichia coli proteome from growth on a protonated full medium, over a protonated minimal medium

130 solenoid is composed of a single peptide and protonated Glu8 is located in the fibrillar core.

131 NMR, we show that as [H(+)] is increased to protonate Gluex and enrich the outward-facing state, a r

132 Upon ring rotation, the protonated glutamate encounters the matrix channel and d

133 s are in a beta-solenoid conformation with a protonated glutamate residue in their fibrillar core.

134 on content regarding the glycan structure of protonated glycoconjugates is hindered by the inability

135 om donor-acceptor exciplexes that are either protonated (H) or deuterated (D).

136 1)H-based resonance assignments of the fully protonated heptahelical membrane protein proteorhodopsin

137 salt, which results in the formation of the protonated heterodimer.

138 We suggest that similar protonated high-valent Fe-oxo species may occur in the a

139 tro, consistent with deprotonated-Glu214 and protonated-His230 serving as a general base and a genera

140 With three basic nitrogen atoms that can be protonated, Hoechst can exist as cationic and neutral sp

141 dent of whether the nicotine is free-base or protonated, however the liquid vehicle has a strong effe

142 ample of the ionic structure incorporating a protonated hydrazone motif linked to the 1,2,5-oxadiazol

143 nd enhanced endosomal escape promoted by the protonated imidazole moieties.

144 iently hydrated when His413 was fixed in its protonated imidazolium state, but its calculated pKa is

145 These isomers become protonated in 58 mus and 3.2 ms, respectively, resulting

146 the periplasmic half-channel is more easily protonated in a manner that halts ATPase-driven rotation

147 nd reduced RsrR, respectively, (ii) His33 is protonated in the In state due to a change in its pK(a)

148 That E115 is likely to be protonated in the inward-occluded state and deprotonated

149 stent with the accumulation of a reduced and protonated intermediate.

150 transitions for metaldehyde (177 --> 149 for protonated ion) and atrazine (221 --> 179) were found to

151 These sodiated ions interfere with protonated ions of the species of the same lipid class w

152 e unachievable for their [M + 2H](2+) doubly protonated ions.

153 the gas-phase reactivity of several isomeric protonated (iso)quinoline- and acridine-based biradicals

154 T studies, cement its assignment as the ring-protonated isomer, [Fe(I)(endo-eta(4)-Cp*H)(dppe)(CO)](+

155 Both endo- and exo-ring-protonated isomers are calculated to have an exceptional

156 vocal evidence for the formation of the ring-protonated isomers Cp*( exo/ endo-eta(4)-C(5)Me(5)H)Co(+

157 d E286 is likely facilitated for states with protonated K362 and unprotonated E286, which would in pr

158 d E286 is likely facilitated for states with protonated K362 and unprotonated E286.

159 Potentiometric studies of protonated L with the series of dianions from succinate

160 ions, as is demonstrated by the isolation of protonated l-glutamine and l-lysine (Delta m/z = 0.0364)

161 -fold with no change in K(d) The affinity of protonated LacY for sugar has an apparent pK (pK(app)) o

162 ugh mode, 7x increase in CID sensitivity for protonated leucine enkephalin (m/z 556), and 14x increas

163 We show that proton transfer from protonated ligand to deprotonated RNA within salt bridge

164 ronic states and material functionalities in protonated material systems.

165 crease the number of Bronsted acid sites, as protonated metal clusters are formed.

166 ach to rationalizing the reactivity of arene-protonated metal species, using decamethylnickelocene as

167 The resulting amine or heterocycle is then protonated/metalated by the catalyst (promotor).

168 Our findings are not limited to the present protonated metallocene system.

169 m growth on a protonated full medium, over a protonated minimal medium, to a completely deuterated mi

170 based on gas-phase ion-molecule reactions of protonated model compounds were successfully conducted a

171 Gas-phase reactivity of protonated model compounds with different functional gro

172 onization technique that yields identifiable protonated molecular ion peaks.

173 ample matrixes based on the accurate mass of protonated molecules (mass error <=5 ppm).

174 On the basis of relative isotope ratios of protonated molecules and measures of exact masses of for

175 oligo(triazole amide)s were best ionized as protonated molecules and were observed to adopt a single

176 was within 6% for 95% of all CCS values for protonated molecules, resulting in a median relative err

177 mined by monitoring proton transfer from the protonated mono- and biradicals to reference bases with

178 upon acidification transport of the neutral, protonated monoacid predominates.

179 In the protonated monocarboxylic form, succinate is rendered a

180 Plots of drift times for pairs of protonated monomer and fragment ions from alcohols, este

181 ion of the proton bound dimer first and then protonated monomer.

182 F) spectra included residual intensities for protonated monomers and fragment ions with characteristi

183 single-digit ppt(v) limits of detection for protonated monomers and hundred ppt(v) limits of detecti

184 Mobility isolated spectra were obtained for protonated monomers of 42 volatile oxygen containing org

185 uced fragment ions by water elimination from protonated monomers of alcohols with carbon numbers thre

186 Fragment ions of protonated monomers of alcohols, acetates, aldehydes, ke

187 Protonated monomers of individual alcohols were mobility

188 ases by approximately a factor of 7 to 9 for protonated monomers, 10 to 14 for proton-bound dimers, a

189 sed alpha functions for the hydrated proton, protonated monomers, and proton bound dimers with increa

190 re electron transfer and yielding a distinct protonated monoreduced complex.

191 nd closely associated LH(+) counter-cations (protonated n-octylamine or tri-n-octylphosphine (TOP) to

192 enerates the methylated histidine in an N(1)-protonated (N(1)-H) and N(3)-methylated form.

193 coupling that AQP9 acts as a channel for the protonated, neutral monocarboxylic acid species.

194 Moreover, the protonated/neutral form of the drug induced more pronoun

195 lly, we demonstrate that the presence of the protonated NH(2) group in sphingosine, which is an amino

196 We also show that the protonated NH(2) group of sphingosine binds to the highl

197 n potential of the previously undetected exo-protonated Ni(I) intermediate.

198 Protonated nicotine (18 mg/mL, medium protonation) e-liq

199 We assessed whether protonated nicotine and e-cigarette devices delivering g

200 solutions that contained either free-base or protonated nicotine at 15 mg/g concentration, with a liq

201 Vype ePen3 with protonated nicotine delivers nicotine more efficiently w

202 Protonated nicotine is less aversive upon inhalation tha

203 many ECIG manufacturers have begun marketing protonated nicotine products, often with high nicotine c

204 ven at -78 degrees C, in the HF/MF5 systems, protonated nitramine MF6(-) salts were isolated for the

205 t the same time, unexpected specifics of the protonated NMe2/-N horizontal line systems consist of a

206 without a significant difference between the protonated (nonionic) or deprotonated (anionic) states.

207 PCP(+) intermediates are neither edge-protonated nor corner-protonated (normally) but possess

208 iates are neither edge-protonated nor corner-protonated (normally) but possess "closed" structures me

209 Diglyceride DG(18:1/20:0)-sodium adduct and protonated octadecanamide ions were found to have greatl

210 These results indicate that the majority of protonated octamer observed in mass spectra under previo

211 Protonated octamer was observed for all tip sizes with 1

212 of levoglucosan and cis-pinonic acid, while protonated oleic acid and 5alpha-cholestane molecules re

213 solid state, depending on the counterion, O-protonated or N-protonated cations can be formed, in acc

214 h the conserved central histidine residue in protonated or neutral form.

215 osecond, MD simulations of the system having protonated or unprotonated cytosines, mimicking the pH 5

216 e (ECIG) liquids can exist in a free-base or protonated (or "salt") form.

217 the fluorescence intensity upon either fully protonating, or deprotonating, the fibrils at pH = 0 or

218 ned from putative APX-II crystals indicate a protonated oxygenic ligand at 1.88 angstrom from the hem

219 n to further increase the relative amount of protonated PAHs, while the introduction of other dopants

220 The interaction prevented conversion into protonated, partially unfolded (green) phycocyanin speci

221 es of the (D)P and (L)P diastereomers in the protonated peptide [YAPAA+H](+), where only intramolecul

222 Therefore, dominant b/y ions upon UVPD of protonated peptides are a strong indicator for the occur

223 The reason is that the protonated peroxide product is always very high in energ

224 erent solutions (free-base/PG, free-base/VG, protonated/PG, and protonated/VG).

225 alternative via formation of a higher-energy protonated phenyl tautomer (2H(+)) prior to C-C bond bre

226 solutions and in soft source conditions, the protonated phosphate groups are fully back-exchanged in

227 ordinary carboxylic acid and to efficiently protonate physiological-like bases.

228 of N-oxide and sulfoxide functionalities in protonated polyfunctional drug metabolites.

229 absorption spectroscopy, we characterize its protonated precursor TyrOH(*+), and we show this species

230 Here, we show in two fully protonated proteins that, at 100-kHz MAS and above, spec

231 asurements between spin-labels on multimeric protonated proteins using double electron-electron reson

232 propylamino)cyclopropenimine-substituted bis-protonated proton sponge as a bifunctional phase-transfe

233 son, the report that a molecule as simple as protonated pyridine (PyH(+)) could catalyze the formatio

234 The gas-phase reactivities of several protonated quinoline-based sigma-type (carbon-centered)

235 cals were also found to increase (making the protonated radicals less acidic) as the distance between

236 etinal, and 2) charge separation between the protonated retinal Schiff base (RSBH(+)) and its counter

237 In dark-adapted ChR2, the protonated retinal Schiff base chromophore (RSBH(+)) ado

238 n visible-absorbing rhodopsins, which bind a protonated retinal Schiff base for light absorption, UV-

239 a residue adjacent to Tyr(179), Asp(178), is protonated revealed a conformational change in Pho84 fro

240 d demonstrated that their imine bonds can be protonated reversibly, causing significant protonation-i

241 N(epsilon) and N(delta) recorded in a fully protonated sample with 100 kHz magic-angle spinning.

242 on of a photon, its chromophore, the retinal protonated Schiff base (RPSB), isomerizes from its nativ

243 ween residues E90, E123, D253, N258, and the protonated Schiff base (SBH), as well as nearby residues

244 t redundancy in this system is provided by a protonated Schiff base adduct of retinaldehyde and tauri

245 hat specifically isomerizes the retinylidene protonated Schiff base both thermally and photochemicall

246 iminished following reduction of the retinal protonated Schiff base double bond.

247 by mimicking the intermediate Opsin-derived, protonated Schiff base in the visual cycle with simple p

248 igand, 11-cis-retinal (11CR), by a covalent, protonated Schiff base linkage.

249 chromophore in opsin visual pigments is the protonated Schiff base of 11-cis-retinaldehyde (11cRAL).

250 elices H5 and H6, while deprotonation of its protonated Schiff's base triggers the rearrangement of t

251 l over the photoisomerization of the retinal protonated Schiff-base in bacteriorhodopsin, isorhodopsi

252 At 100 muM, the population abundance of the protonated serine octamer decreases from 1% to 0.6% from

253 For example, both singly protonated serine octamers and anionic octamers complexe

254 ween the peptide forms present today and the protonated signalling peptides likely to be dominating i

255 caused by residual sulfolane that stabilizes protonated sites on the protruding chains, thereby promo

256 rrogate for cyclic terpenes, are followed as protonated species (CI)H(+) using protonated amines as r

257 n of the metal hydride [1-MH](+) to a ligand protonated species [1-LH](+), from which ligand dissocia

258 of the deprotonated species compared to the protonated species and (ii) stronger electrochemical int

259 Our assignment of the latter ring-protonated species contrasts with its previous reported

260 ion between the metal-hydride and the ligand protonated species provides a low energy pathway for lig

261 e resolved in another, and epimers merged as protonated species were resolved upon metalation, effect

262 er reduction of the pH results in the doubly protonated species with a high electron-deficiency and L

263 in energy- and time-resolved spectroscopy of protonated species, which leads to a growing demand for

264 ecursor charge states, especially for doubly protonated species.

265 (t)BuPy] dependent equilibrium with a ligand protonated square-planar Ir(I) [Ir(N(NN(H))(2))(CO)](+)

266 h the reversible chemical transition between protonated state (NH(+) ) and deprotonated state (N).

267 Surprisingly, one ligand binds to trypsin in protonated state and to thrombin in unprotonated state a

268 Moreover, a different protonated state of 1a with a proton hosted in the outer

269 sting that ligand binding is favoured by the protonated state.

270 aving an ortho-substituent and/or being in a protonated state.

271 Additionally, all of the involved protonated states of the compound exhibit discriminative

272 Protonated states of the nitrogenase active site are mec

273 ration acts as a nucleophile and attacks the protonated substrate via an outer-sphere mechanism.

274 llowed by hydrogen atom abstraction from the protonated sulfur atom in DMDS by the radical site in th

275 gold nanorod and partially localized on the protonated support hydroxyl group.

276 the article, which excludes anionic and most protonated systems, methods associated with measuring th

277 nteractions of the oppositely charged paper (protonated tertiary amine groups) and the anionic groups

278 Using protonated tetrafluoroborate salts, a strong counterion

279 duct with protonated ethers, preferably with protonated tetrahydrofuran.

280 ne for Calpha deprotonation, His-123 acts to protonate the Ala-enamine intermediate, and Arg-56 facil

281 rbamic acid, which is sufficiently acidic to protonate the reduced Mn species and generate an interme

282 On the one hand, it protonates the N-heterocycles that reduces their reducti

283 OPC-CoA and Tyr-344 as the general acid that protonates the propionyl-CoA anion following C-C bond cl

284 At pH 4, where His residues are protonated, the PLD is disordered and flexible, except f

285 When protonated, the resulting 1,2,3-triazolium ions lose the

286 onal imine-linked COF powders by temporarily protonating their linkages.

287 c acid, alkenes behave as Bronsted bases and protonate to give carbocations which can be trapped by e

288 that a nitrogen-fixing Fe-N2 catalyst can be protonated to form a neutral Fe(NNH2) hydrazido(2-) inte

289 Compound 10 can be reversibly protonated to yield the [t-Bu(2)PHC(S)SCH(Me)Ph](+) cati

290 unprecedented two-step mechanism wherein the protonated triradical first transfers a proton to DMDS,

291 e of the highly-conserved catalytic triad is protonated upon 5'-splice-site scission, promoting a rev

292 hexahydro-2H-pyrimido[1,2-a]pyrimidine) were protonated using [HNEt3][BPh4] to afford [I-H][BPh4] (1a

293 ee-base/PG, free-base/VG, protonated/PG, and protonated/VG).

294 (2)O)(19) isotopologue of the "magic number" protonated water cluster, H(+).(H(2)O)(21) The OH group

295 The protonated water tetramer H(+)(H2O)4, often written as t

296 that maintains the retinylidene Schiff base protonated when the channel is open.

297 P could be protonated with 2,6-lutidinium triflate, yielding the lo

298 the arene ligand to the point that it can be protonated with a mild Bronsted acid (diphenylammonium t

299 15)N NMR spectra show that the His-27 tetrad protonates with higher pKa values than His-19, indicatin

300 cytotoxic compounds that are differentially protonated within the physiological pH range.