ライフサイエンスコーパス: protracted

1 se the timeline for LF in this setting seems protracted.

2 not quantitative, lack sensitivity, and are protracted.

3 everal weeks, and the course of infection is protracted.

4 accine candidates are commonly laborious and protracted.

5 ced swim test (FST) is revealed only after a protracted (2 weeks), but not acute (24 h), abstinence p

6 hours), short-term (3 consecutive days), and protracted (7 days after the last of three consecutive d

7 It then persists into protracted abstinence and contributes to the development

8 Hyperkatifeia can extend into protracted abstinence and interact with learning process

9 The effects of protracted abstinence following long-term ethanol self-a

10 rug-paired stimuli following 2 or 5 weeks of protracted abstinence from chronic drug exposure as comp

11 ibutes to increased motor impulsivity during protracted abstinence from long-term alcohol exposure.

12 hdrawal symptoms during acute withdrawal and protracted abstinence in rats previously exposed to chro

13 this model a hyperdopaminergic state during protracted abstinence is associated with vulnerability f

14 withdrawal signs, whereas anxiety linked to protracted abstinence is attenuated by pioglitazone inje

15 inistration during both acute withdrawal and protracted abstinence test sessions, whereas KOR antagon

16 l, whereas excessive anxiety associated with protracted abstinence was prevented by pioglitazone micr

17 anticipatory signals recover or adjust after protracted abstinence will be important in understanding

18 al transcriptional regulatory network during protracted abstinence, a period when relapse rates are h

19 s in alcohol dependent patients in early and protracted abstinence, and in comparison with control su

20 During early withdrawal and protracted abstinence, the expression of PPARgamma incre

21 a phenocopy of alcohol-dependent rats during protracted abstinence.

22 f-administration during acute withdrawal and protracted abstinence.

23 rawal assessment during acute withdrawal and protracted abstinence.

24 d and stress systems are dysregulated during protracted abstinence.

25 e preference when drug is experienced during protracted abstinence.

26 itioned for morphine place preference during protracted abstinence.

27 of orexin neurons for morphine reward during protracted abstinence.

28 The epibatidine analogs produced protracted activation of high sensitivity (HS) alpha4- a

29 y and liver injury due to early, robust, and protracted activation of NF-kappaB in the absence of bet

30 model further suggested that the relatively protracted activation of the RAF-MEK1/2-ERK1/2 module, i

31 erapeutic strategies for mycosis require the protracted administration of antifungals, which can resu

32 Such protracted aggregation has profound implications for our

33 on favors mature B cell cancers by eliciting protracted AID expression in GC B cells.

34 eceptor in excessive alcohol drinking during protracted alcohol abstinence.

35 re (AIE) on negative affect during acute and protracted alcohol withdrawal and following stress in ad

36 the underlying neurobiological substrate for protracted amygdala growth into adulthood is unclear, we

37 on of lineages that originated owing to more protracted and complex interactions between biological a

38 evelopment of the eye, potentially replacing protracted and costly multidisciplinary assessments and

39 formation with standard methods is typically protracted and inefficient, resulting in heterogeneous c

40 fires were also present but more delayed and protracted and likely played a less acute role in biotic

41 sition to agriculture in southwest Asia as a protracted and multiregional process.

42 The identification of the isolate was protracted and ultimately dependent upon sequence analys

43 e expectancy and the dying trajectory can be protracted and unpredictable.

44 (BLA), neuropeptide Y (NPY) buffers against protracted anxiety and fear.

45 otent signature in early embryos, there is a protracted appearance of a primed signature in advanced

46 But political instability and protracted armed conflict, with significant disruption o

47 The protracted arrest in meiotic prophase makes oocytes part

48 small leucine-rich proteoglycan, initiates a protracted autophagic program downstream of VEGF recepto

49 ht chain 3 alpha genes, thereby leading to a protracted autophagic program.

50 s to bacterial coinfection, in children with protracted bacterial bronchitis (PBB) and mild bronchiec

51 Acute SARS-CoV-2 infection leaves protracted beneficial (ie, activation of T cells) and po

52 ng in a flood of new molecular insights into protracted biological questions.

53 subconductance states, with B-973B producing protracted bursts, even in the presence of mecamylamine.

54 of Cambrian Series 2 (~521 Ma), suggesting a protracted but cryptic earlier history that possibly ext

55 This process of protracted but episodic erosion of legacy sediment and a

56 tles was not temporally synchronized but was protracted by several decades, compared with stand devel

57 eliminates the basis for earlier theories of protracted childhood and prolonged post-menopause longev

58 s for severe seasonal influenza and the more protracted clinical course compared with that of H5N1 su

59 The protracted clinical course of the MPNs has limited the u

60 The majority of patients show a protracted clinical course with persistent disease.

61 Due to their protracted clinical course, the evolution to advanced he

62 aparesis, dementia, blindness) and different protracted clinical forms of GM1- and GM2-gangliosidoses

63 versity in inactive genes is indicative of a protracted clonal evolution and consequently, increased

64 d people with missing doses, and despite the protracted collection of interview information necessary

65 (2.5 min), transient (peaks at 15 min), and protracted compared with receptor tyrosine phosphorylati

66 Protracted conflicts in the Middle East have led to succ

67 Finally, alongside protracted conflicts, widening of health and socioeconom

68 it is crucial to highlight the immediate and protracted consequences of cannabis exposure on pre- and

69 Memories of frightening events require a protracted consolidation process.

70 nd the established adverse effect profile of protracted corticosteroid use, this analysis substantiat

71 ith detectable food-specific IgE, can have a protracted course and eventually transition to acute rea

72 immunodeficiency virus (HIV) may have a more protracted course.

73 th obinutuzumab for follicular lymphoma with protracted COVID-19 and viremia.

74 a very promising approach in the context of protracted COVID-19 symptoms in patients unable to mount

75 This article describes protracted crises and argues that they are sufficiently

76 n assumptions that do not fit the context of protracted crises.

77 here are unique constraints to engagement in protracted crises.

78 Ordovician extinctions, our study suggests a protracted crisis interval linked to intense volcanism d

79 long-acting methods, are available, even in protracted crisis settings.

80 Plutons are formed by protracted crystallization of magma bodies several kilom

81 oimmune diseases, but the standard method is protracted, cumbersome and prone to error.

82 I interferon response initially, but also a protracted cytokine response after seroconversion, marke

83 With protracted damage, fibrosis can progress toward excessiv

84 vere cognitive and physical impairments, and protracted deaths in the hospital setting.

85 solutions that may easily become enmeshed in protracted debate and controversy as they encounter the

86 We measured pupil size while subjects formed protracted decisions about the presence or absence ("yes

87 These data indicate a protracted decline in occupation within the economic and

88 stically, 5hmC enrichment is followed by its protracted decline thereafter at a rate consistent with

89 a multi-hour circulation half-life, offering protracted delineation of vasculature.

90 ry as an exemplar case (given this network's protracted development across these ages).

91 s in the paralaminar nuclei (PL), suggesting protracted development and possibly neurogenesis.

92 Critically, protracted development contributes to the plasticity of

93 putational and neural mechanisms, which show protracted development in childhood and are affected by

94 he face perception task was driven mainly by protracted development in identity perception, while gaz

95 ent of PSD-95 and GluA2 into late childhood, protracted development of GluN2A until approximately 40

96 ation might be improved by accommodating the protracted development of human neural cells.

97 n of error-processing abilities supports the protracted development of inhibitory control over adoles

98 The protracted development of structural and functional brai

99 The protracted development of the cortex and its connections

100 We used RNA-seq and exploited the protracted development of the parasitic nematode Ascaris

101 uisition of these functions is linked to the protracted development of the prefrontal cortex (PFC) an

102 gyrus (DG) is a unique cortical region whose protracted development spans the embryonic and early pos

103 This protracted development was specific to first-person pers

104 tic inhibition mediated by PVINs undergoes a protracted development, it does not exhibit a fear behav

105 The human cerebellum has a protracted developmental timeline compared with the neoc

106 old, in order to study play contagion over a protracted developmental window.

107 The microbiologic causes of protracted diarrhea include detectable parasitic (eg, Gi

108 s, but how we respond to them can range from protracted disability to resilience and growth.

109 ducation were associated with higher risk of protracted disability.

110 opy of Mecp2 (Mecp2(ZFN/+)) displayed a more protracted disease course.

111 s in effective population size due to both a protracted domestication bottleneck and serial founder e

112 nd its wild relatives, suggesting a gradual, protracted domestication process.

113 Interestingly, asymmetry develops in a protracted dorsoventral wave, whereas lamination does so

114 Before protracted drug exposure, most rats prefer natural rewar

115 with alterations in reward valuation during protracted drug withdrawal.

116 larger entity, but elimination may still be protracted due to incomplete dispersion of gold.

117 sistent with a basic emotion, especially its protracted duration and frequently cold phenomenology.

118 jor psychoactive component of cannabis, with protracted effects on adult neural systems relevant to p

119 CBD also showed significant protracted effects on these measures 7 days after the fi

120 Here we show that this protracted EN event, combined with the regional warming

121 Antibodies to DPPX are associated with a protracted encephalitis characterized by central nervous

122 These data demonstrate that protracted endogenous fibrinolysis induced by TBI is pri

123 Using protracted episodic expression of Omomyc, we now demonst

124 tic regulation of Ca(2+) channels promotes a protracted ER stress with the consequent activation of E

125 Protracted exposure of neurons to stress led to neurotox

126 We show that protracted exposure to kin or non-kin odorants changes t

127 mated relative risks of CLL and non-CLL from protracted exposures to low-dose ionizing radiation.

128 on are well known, but risks associated with protracted exposures, as well as associations between ra

129 ction-related memory processes suggests that protracted extinction training following brief cue-elici

130 tor activity that is either too brief or too protracted fails to sufficiently open T-type channels ne

131 All the patients with protracted fecal HEV shedding during treatment suffered

132 nodules is time-consuming and often leads to protracted follow-up with ongoing radiological surveilla

133 e changes in gene expression associated with protracted forced abstinence.

134 In NSCs, OxPhos dysfunction leads to a protracted G(1)/S-phase and results in delayed temporal

135 tion of septum formation and a significantly protracted G1 arrest.

136 eath after selinexor treatment occurs from a protracted G1-phase and early S-phase.

137 Public health officials investigated a protracted GAS outbreak in a skilled nursing facility in

138 Protracted glucocorticoids exposure during pregnancy can

139 Furthermore, [dA(2)]GLP-1/GcG elicited a protracted glucose-lowering and insulinotropic effect in

140 ce cue receptor, controls the extent of this protracted growth by determining where and when dopamine

141 ation in the amygdala follows the pattern of protracted growth in TD and early overgrowth in ASD and

142 arth masses within <1 My, followed by a more protracted growth to approximately 50 Earth masses until

143 ly applied to inform real-time operations in protracted health emergencies.

144 itry and determined how they interact with a protracted history of cocaine self-administration.

145 For the most protracted hot and dry events, the strongest and most wi

146 valuation II at admission (<20) and prone to protracted ICU stay may benefit most from rehabilitation

147 ight for the prolonged viral replication and protracted illness observed in H5N1-infected patients.IM

148 ralized T cell paralysis as a major cause of protracted immune suppression from sepsis.

149 ng features of hyperinflammation, as well as protracted immune suppression.

150 ase but little is known regarding a possible protracted impact of COVID-19 on the adaptive and innate

151 mented by cocaine administration and is more protracted in rats that were permitted to receive the dr

152 ommitment of CML cells to apoptosis requires protracted incomplete restoration of BCR-ABL signaling m

153 ber formation, and produced an amplified and protracted increase in endothelial permeability in respo

154 ministration group was distinguished by more protracted increases in adrenocortical activity compared

155 tients for whom material was not removed had protracted infection despite prolonged antibiotherapy; 3

156 s (CTLs) play an important role in resolving protracted infection with hepatitis B and C virus in hum

157 The protracted infertility observed in PZP-treated horses ma

158 Specifically, protracted inflammation after acute injury has been asso

159 Protracted inflammation may result in aberrant adenosine

160 eficiency virus (HIV) infection is driven by protracted inflammation; the primary loss of CD4(+) T ce

161 Despite this protracted interval of core formation, the iron meteorit

162 nce times for FK228 at HDAC1, explaining the protracted intracellular behaviour of this prodrug.

163 ell imaging revealed that death occurs after protracted loss of OM material through vesiculation and

164 Transcriptomic analysis showed that during protracted low-grade H(2)O(2) stress, Escherichia coli r

165 uced alveolar fraction which corresponded to protracted lung inflammation.

166 ropriate behavioral responses, develops in a protracted manner and is compromised in several prevalen

167 g a pyrin domain 3 (NLRP3) inflammasome in a protracted manner, leading to an up-regulation of IL-1be

168 g a globally diachronous biotic turnover and protracted mass extinction event.

169 cingulum bundle may play a critical role in protracted maturation of executive functioning.

170 ortex (DLPFC) and appear to arise during the protracted maturation of this circuitry across childhood

171 of amygdala-mPFC circuitry may underlie the protracted maturation of threat regulatory processes.

172 gest that the mesofrontal circuit exhibits a protracted maturation through adolescence.

173 than anything previously observed following protracted MD in cat, and they highlight a possibility f

174 in patients upon proinflammatory challenge; protracted modulation of the inflammatory environment is

175 This protracted, multistage process for the production and st

176 s of satellite cells and exhibit delayed and protracted muscle regeneration, and satellite cell-deriv

177 t Asia by highlighting the multiregional and protracted nature of plant domestication.

178 The protracted nature of seafloor methane emissions probably

179 al expansion has recently been attributed to protracted neurogenesis by outer radial glial cells in t

180 valuated whether HMGB1 antagonism blocks the protracted neuroinflammatory and sickness response to pe

181 tinued expression of DCX in brain areas with protracted neuron recruitment has promoted this endogeno

182 ogenitor decommissioning are co-regulated in protracted neuronal lineages.

183 eatment regimen (especially in patients with protracted neutropenia), and how long to continue antimi

184 phoebe song unexpectedly develops through a protracted ontogeny.

185 with initial DFU cultures yielding MRSA and protracted open ulcers had a high 24-month cumulative pr

186 Protracted opiate withdrawal is accompanied by altered r

187 monstrated a role for large SPSSs in chronic protracted or recurrent HE and substantiated the effecti

188 or antagonist preserves choroid and prevents protracted outer neuroretinal anomalies in OIR, suggesti

189 combination of these factors may explain the protracted oxygenation of Earth's surface over the last

190 The protracted path toward Gavi support for TCV highlights t

191 of a coarse-grained model system reproduced protracted pausing and stalling, which suggests that the

192 Using protracted PC_DCN activation (120 s) to mimic background

193 clude that naked mole rats show an extremely protracted period of brain maturation that may permit pl

194 Studies using mouse models of ALS indicate a protracted period of disease development with progressiv

195 arly cancer cell dissemination followed by a protracted period of dormancy potentially explains this

196 between these warblers likely results from a protracted period of hybridization, contradicting the br

197 The Late Devonian was a protracted period of low speciation resulting in biodive

198 dell seal, a long-lived marine mammal with a protracted period of maternal care during which mothers

199 approximately 3,500 years ago, suggesting a protracted period of population size reduction likely co

200 ganglion cell connectivity undergoing a more protracted period of refinement.

201 epoch of nonspecific responses followed by a protracted period of taste-specific firing.

202 on the DNA behind the replication fork for a protracted period of time, allowing them to form a docki

203 imate cortical progenitors proliferate for a protracted period of time, during which they generate ea

204 holinergic neurons in the ENS develop over a protracted period of time.

205 ions of ethylene or indole-3-acetic acid for protracted periods (more than 24 h) of time.

206 s modulate the activity of POMC neurons over protracted periods of time.

207 es in 2050-2069 peak stream temperatures and protracted periods of warming from May to September (MJJ

208 erapies must target both the initial and the protracted phase of the syndrome to relieve early immuno

209 of the amygdala (BLA), which correlates with protracted plasma corticosterone release.

210 in this time frame, suggesting that the more protracted post-ictal state cannot be explained by persi

211 in determining human health risk in space or protracted post-treatment normal tissue toxicity.

212 layed cognitive development in children, and protracted postinfectious syndromes.

213 The protracted postnatal development of sparse, selective fi

214 ructures, and this trend likely reflects the protracted postnatal development of the cortex.

215 man traits, including exceptionally slow and protracted preadult growth.

216 Although protracted prefrontal gray matter development is associa

217 idation Event (GOE) is currently viewed as a protracted process during which atmospheric oxygen incre

218 Despite (and perhaps because of) a protracted process of deliberation and argument about wh

219 ication - that in general domestication is a protracted process, that unconscious (natural) selection

220 During postnatal development, there was a protracted, progressive sparsification of responses, acc

221 epidemiological investigation suggested that protracted radiation exposure increases radiation-induce

222 ses in water and temperature stress that are protracted, rapid, or both, drive a gradient of tree str

223 g embolic chemoembolization as predictors of protracted recovery because of postembolization syndrome

224 The protracted recovery of CFA motor performance demonstrate

225 extinction mechanism and explanation for the protracted recovery period, yet the vertical distributio

226 However, protracted recruitment of stress systems can precipitate

227 has become a focus in recent years, but the protracted recurrence of disease and unknown adverse ocu

228 ing regular marijuana use but decreased with protracted regular use.

229 ptor demonstrated a unique role for GID1a in protracted response to GA that was saturated only at hig

230 rsive tastes, high spontaneous firing rates, protracted responses, and broader tuning.

231 We find that neurons with protracted resting temporal receptive fields exhibit str

232 hexol) nanoparticles exhibited substantially protracted retention within the tumor bed and a 36-fold

233 took part in a memory retrieval task with a protracted retrieval trial consisting of an initial memo

234 ucture involve either spatially resolved but protracted scanning probe experiments without real time

235 d slowly declines over 20 min to support the protracted secretory response.

236 sistent with recovery of immunocompetence in protracted sepsis.

237 ng nodes that facilitate AXL-RTK cross-talk, protracted signaling, converging on ERK, and PI3K axes.

238 diversity, but little is known about how the protracted spatial dynamics of this transition impacted

239 In conclusion, the protracted spread of pandemic influenza in fall 2009 in

240 reaction, if not treated early, shifts to a protracted state of immunosuppression that alters both i

241 f the stabilized step function opsin (SSFO), protracted stimulation of the SC was achieved with only

242 After protracted stimulation, the beta2-adrenergic receptor an

243 Protracted stress primed enhancers for rapid increases i

244 Together, our results demonstrate that protracted subversion of immune dynamics contributes to

245 among the majority of human pregnancies, to protracted surface area alterations, that preferentially

246 subsequent unscheduled physician encounter, protracted symptoms, crossover, and 3% or more weight lo

247 o an increase in E and I synapse density and protracted synapse maturation, traits characterizing hum

248 T19, recognized leukemic blasts, established protracted synapses, and eradicated CD19-negative leukem

249 Mice of TCL1A-initiated protracted T-PLL development resembled such features.

250 llosteric activation by B-973B appeared more protracted than that produced by GAT107, and B-973B resp

251 This preferential binding protracted the depolymerization kinetics of Lys48-linked

252 miliarity, however, they moved more rapidly, protracted their whiskers further, and showed decreased

253 tionally blind animals moved more slowly but protracted their whiskers further.

254 replicating mycobacteria responsible for the protracted therapy required to cure tuberculosis.

255 m hypothesis to obtaining the results can be protracted, thus limiting the number of compounds that c

256 and between organoids that can change over a protracted time course of differentiation.

257 ectly with soluble compounds and, for a more protracted time, through alteration, processing, and rel

258 lying affective learning capitalizes on this protracted timeline to develop a rich affective repertoi

259 d in meningoencephalitis and death on a more protracted timeline, 1 to 2 weeks after initial OROV or

260 response upon reexposure to antigen even at protracted times postinfection.

261 However, the protracted timing of human neuron specification and func

262 atmosphere, emphasizing the strong role the protracted transmission of catchment responses to distan

263 in mouse pluripotent stem cells compared to protracted trends in human pluripotent stem cells.

264 polymeric prodrug resulted in increased and protracted tumor drug exposure compared with CPT-11, lea

265 nefit from decades of research but are often protracted, unamenable to diversification, and reliant o

266 ent with Sigma1 ligands, which suggests that protracted UPR results in autophagy as a secondary respo

267 Nonetheless, (11)C-GR103545 displays protracted uptake kinetics and is not an optimal radiotr

268 The recurrent and protracted use of antiviral drugs with eventual emergenc

269 einforcing effects of abused drugs, but with protracted use the dorsolateral striatum is thought to a

270 excessive drug intake that emerges following protracted use.

271 ors had a history of either ocular trauma or protracted uveitis.

272 derwent fewer tracheostomies and episodes of protracted ventilation.

273 less snow resulted in longer lags and a more protracted vernal window.

274 In the face of chronic cancers and protracted viral infections, human immune cells are know

275 ntional therapies to stimulate recovery from protracted visual deprivation.

276 Protracted war and armed conflicts have displaced popula

277 e evolution of Arctic polar climate from the protracted warmth of the middle Pliocene into the earlie

278 whisker positions in the turn direction and protracted whisker movements on the other side.

279 changed in concert with running so that more protracted whisking was correlated with faster running.

280 viscously relaxed or that Ceres experienced protracted widespread resurfacing.

281 found collapse prior to axon termination is protracted, with the growth cone transitioning from a dy

282 HT sensitivity, which partially recovered in protracted withdrawal (2 weeks).

283 Alcohol dependence and protracted withdrawal did not alter either 5-HT1A-mediat

284 s into how both chronic alcohol exposure and protracted withdrawal dysregulate 5-HT signaling in the

285 dU cells, and methamphetamine seeking during protracted withdrawal enhanced Fos expression in the den

286 tion mediate resistance to extinction during protracted withdrawal from a history of extensive cocain

287 Protracted withdrawal from cocaine experience increases

288 in cell number and activity persisted during protracted withdrawal from cocaine for at least 150 days

289 Exposure to predator odor during protracted withdrawal from intermittent alcohol drinking

290 Protracted withdrawal from self-administration enhanced

291 split effects (increase and decrease) after protracted withdrawal indicative of neuroadaptations of

292 use, and typically sudden onset, severe, and protracted withdrawal symptoms when medication was stopp

293 perglutamatergic state within the NAC during protracted withdrawal, characterized by elevated metabot

294 After protracted withdrawal, cocaine-experienced animals exhib

295 l of DA neurons by tVTA is maintained during protracted withdrawal, the capacity for disinhibitory co

296 inhibition of VTA DA neurons observed during protracted withdrawal.

297 behavioral responses to predator odor during protracted withdrawal.

298 ession in the nucleus accumbens core after a protracted withdrawal.

299 seeking akin to cocaine-experienced rats in protracted withdrawal.

300 f the CeA 5-HT system to chronic alcohol and protracted withdrawal.SIGNIFICANCE STATEMENT Elevated GA

301 The reestablishment of widespread and protracted WPV1 transmission in the DRC and Angola follo