ライフサイエンスコーパス: proven

1 t cancer (MCF-7) and melanoma (SK-MEL-5) was proven.

2 Fifty-two culture-proven (52 eyes) cases of MRSA keratitis diagnosed and t

3 Accelerometry has proven a powerful tool to estimate energy expenditure, b

4 ejection fraction (LVEF) alone has not been proven a reliable predictor of SCD.

5 d extraterminal (BET) family of proteins has proven a valid strategy for cancer chemotherapy.

6 Owing to the proven abundance of phenolics in the investigated wood e

7 Of all 92 QFT-G-positive patients, culture-proven active TB was observed in 1 case.

8 Eleven cases of pathologically proven acute gangrenous cholecystitis and 12 consecutive

9 titis and 12 consecutive cases of surgically proven acute non-gangrenous cholecystitis that underwent

10 aHR, 1.68 [1.08-2.62]; P = 0.022) and biopsy-proven acute rejection (aHR, 1.71 [1.13-2.60]; P = 0.012

11 Biopsy-proven acute rejection (BPAR) rates and types were compa

12 n to last follow-up, the incidence of biopsy-proven acute rejection (BPAR) was 77% (37/48) and 66% (3

13 ults for mTORi versus MPA in terms of biopsy-proven acute rejection (hazard ratio [confidence interva

14 uate clinical factors associated with biopsy-proven acute rejection during the first post-transplant

15 Biopsy-proven acute rejection was diagnosed in 21 patients (12.

16 ration rate at 12 months and rates of biopsy-proven acute rejection were also similar between groups.

17 ary endpoints were treatment failure (biopsy-proven acute rejection, graft loss, or death), delayed g

18 of GDF15 to an increased incidence of biopsy-proven acute rejection.

19 3 [4.7%] vs 17 [21.9%], P = .007) and biopsy-proven acute rejections (15 [23.4%] vs 31 [48.4%], P = .

20 Two were biopsy-proven acute rejections with subsequent graft failures.

21 of the primary tumor in patients with biopsy-proven adenocarcinoma or squamous cell carcinoma of the

22 e of patients with at least 1 histologically proven adenoma or carcinoma).

23 reduction over precious-metal catalysts has proven advantageous, but its application to long-term co

24 n addition, material from a range of autopsy-proven ageing-associated and primary tauopathies in whic

25 ion of 38 patients with eventually pathology-proven AIFR (13:25, Mucor:Aspergillus).

26 ive ELISA using sera from 18 subjects with a proven almond allergy.

27 In this Review, we explore proven and novel hypotheses for how modifiable risk fact

28 The incidence of probable/proven and possible CAPA in this subset of patients was

29 press chimeric antigen receptors (CARs) have proven - and impressive - therapeutic activity in patien

30 Three proven anti-IRI agents not in widespread clinical use, C

31 There is no proven antiviral or immunomodulatory therapy for coronav

32 rs) and risk for possible aortic dissection (proven aortic dissection plus death of unknown cause, 0.

33 he concept of "memory of chirality" has been proven as a powerful tool in asymmetric synthesis, while

34 IDP' in view of clinical similarity, but not proven as yet.

35 Culture-proven aspiration pneumonia and early-onset ventilator-a

36 tudy reports outcomes for adults with biopsy-proven B-cell PTLD treated initially with R-Mono or Ritu

37 Diagnosis of PTLD was biopsy-proven based on World Health Organization histologic cri

38 admitted to the intensive care unit, with a proven benefit for critically ill patients.

39 Despite the proven benefits of nonhospice PC for other serious illne

40 ren with persistent BKPyV-DNAemia and biopsy-proven BKPyVAN with need for therapeutic intervention.

41 ose with persisting BKPyV-DNAemia and biopsy-proven BKPyVAN, who would benefit from individualized th

42 of therapeutic intervention and diagnosis of proven BKPyVAN.

43 ths and the material efficacy and safety was proven both in vitro and in vivo.

44 ma cell line with high metastatic potential, proven by a xenotransplant in zebrafish larvae, we have

45 etic utilities of few synthesized TRAMs were proven by carrying out bromination on the -OH-containing

46 tinct types of SCMs are identified, and then proven by computational construction.

47 velopment of cognitive alterations has to be proven by further longitudinal studies.

48 The feasibility of the methods was proven by investigating restricted diffusion of water in

49 0% after treatment with (225)Ac-PSMA-617 was proven by multivariate analyses to be significantly asso

50 tissue-dependent interaction with miRNAs, as proven by reporter gene assays.

51 c value of this asymmetric reaction has been proven by the formal synthesis of the naturally occurrin

52 The concept functionality was proven by using both artificial and multiple natural pro

53 packings comprising dry small particles, as proven by X-ray nanotomography.

54 ive (1,3)-beta-D-glucan (BDG) in adults with proven candidemia is unknown.

55 In 12 patients with EMB-proven cardiomyopathy, EVM identified pathological areas

56 management of the patient with suspected or proven cardiovascular complications of coronavirus disea

57 which auxin transport has been conclusively proven carry this conserved motif, underlining its predi

58 viewed the unenhanced CT scans of surgically proven cases of acute gangrenous (GCh) and non-gangrenou

59 ing (MRI) findings in 23 histopathologically proven cases of HAE with emphasis on the appearance and

60 centers (Boston, MA), 14 adults with biopsy-proven CeD were randomized to 3 g or 10 g gluten/d for 1

61 treatments for Alzheimer's disease (AD) has proven challenging and has instigated a shift in AD rese

62 he effects of these degradation products has proven challenging because of the complexity, transience

63 Interpreting these findings has proven challenging because some phenotypes may reflect c

64 This has proven challenging for genome-wide association studies (

65 or limiting viral spread and disease, it has proven challenging to develop targeted and selective the

66 However, RTs have proven challenging to discover and engineer, in particul

67 tion of a broad range of targets, but it has proven challenging to fabricate suitable three-electrode

68 at millikelvin temperatures-however, it has proven challenging to operate nanoscale optomechanical d

69 of tumor-specific cell surface antigens has proven challenging, as the vast majority of tumor-associ

70 Islamic transition, testing this theory has proven challenging.

71 breeding programs through gene knock-ins has proven challenging.

72 Predicting these consequences has proven challenging.

73 ituent species of an assembled community has proven challenging.

74 ies, but its application to solid tumors has proven challenging.

75 of stem cell-related signaling pathways has proven challenging.

76 tazidime is one of the handful of drugs with proven clinical efficacy against the important opportuni

77 afenib remained the only systemic agent with proven clinical efficacy for patients with advanced HCC.

78 There are no antiviral drugs with proven clinical efficacy for the treatment of COVID-19,

79 of suitable (18)F-labeling technologies with proven clinical relevance.

80 Single-agent immune modulators have thus far proven clinically ineffective, and multi-modal therapies

81 acterize oscillometry measurements in biopsy-proven clinically significant (grade >=2 ACR) in the fir

82 GABAC combines proven coding technologies, such as context-adaptive bin

83 The PPV in the histopathology-proven cohort was 91%, and the CDR in this subgroup was

84 utaneous cryoablation for solitary pathology-proven cT1 RCC between August 2000 and July 2017.

85 Given the paucity of proven data in treating COVID-19, management of these pa

86 oses on biopsy, adding support for pathology-proven data to guide treatment in relevant cases.

87 ults (aged >=18 years) with a pathologically proven diagnosis of SCLC, Eastern Cooperative Oncology G

88 Direct empirical assessment has proven difficult because of the many potential confoundi

89 -like architectures in living cells, but has proven difficult due to the lack of control over defined

90 tes some of these processes; however, it has proven difficult to generate functional hematopoietic st

91 have a constrained Cu(II) geometry that has proven difficult to recapitulate outside native cupredox

92 However, such reactivity has proven difficult to reproduce in solution with man-made

93 cision is correct-known as metacognition-has proven difficult to study in isolation as it usually coo

94 a direct pharmacologic manner and thus have proven difficult to target in the clinic.

95 posed to explain these relationships, it has proven difficult to understand why patterns are so varia

96 ic role of TRIM32 in LGMD2H pathogenesis has proven difficult, as neurogenic phenotypes, independent

97 but acquiring similar evidence in humans has proven difficult.

98 Predicting these limits has proven difficult.

99 basis of the action of glucocorticoids have proven difficult.

100 able molecular players and/or biomarkers has proven difficult.

101 rion in parasitic protozoans is a clinically proven drug target.

102 may significantly alter their expression as proven, e.g., for miR-379 and ABCC2 However, alternative

103 In this study, IFGEM were proven effective and sustainable through an isotherm stu

104 No therapeutics have yet been proven effective for the treatment of mild-illness cause

105 This electrochemical sensor was proven effective in real clinical sera from patients wit

106 ic antigen receptor (CAR) T-cell therapy has proven effective in relapsed and refractory B-cell malig

107 e of treatment response in sRCCs, although a proven effective systemic agent remains elusive.

108 No proven effective therapies for this virus currently exis

109 The compounds discussed in this review have proven efficacious in human cell lines, patient-derived

110 Despite proven efficacy of pharmacotherapies targeting primarily

111 established Rh- or Co-catalysts has thus far proven elusive, thereby limiting access to many syntheti

112 re funneled into polyketide biosynthesis has proven elusive.

113 the NADPH oxidase (NOX2) kills microbes has proven elusive.

114 l interactions of distinct lipid species has proven elusive.

115 VSD in the intermediate state has previously proven elusive.

116 Successes in this domain have proven elusive.

117 nder physiologically relevant conditions has proven elusive.

118 onal (1)H-(15)N correlation experiments have proven exceedingly difficult to implement on mAbs, and a

119 tery using the radiocarbon dating method has proven extremely challenging owing to the limited surviv

120 ting phases in complex quantum materials has proven extremely challenging.

121 for future engineering applications and (5) proven feasibility and biocompatibility in an animal mod

122 divided according to their fertility status: proven fertile (n = 39); primary infertility (n = 11) an

123 or secondary infertility and compare it with proven fertile men.

124 In addition, the method was proven fit-for-purpose for a cohort of 140 adolescents (

125 etween Berry phase and Hannay angle has been proven for a large set of quadratic Hamiltonians, such c

126 experimental productivity, the shutdown has proven for many PIs and trainees that doing and thinking

127 cently covalent engagement to novel E3's has proven fruitful in TPD application.

128 dance monitoring on therapy in patients with proven gastroesophageal reflux disease [GERD]), to docum

129 y in functional heartburn that overlaps with proven GERD.

130 third handheld spectrometer, representing a proven good performance for fruit quality analysis, was

131 tors of the hazard rate of developing biopsy-proven GVHD during the first 60 months posttransplant am

132 ust organic semiconductor photocatalyst with proven H(2) evolution ability.

133 beyond the refractive aspect and has already proven helpful in cases of iris defects and irregular co

134 Of these six women, three had biopsy-proven HER2-positive metastases, two had pathologic find

135 Oral miltefosine in monotherapy has proven high efficacy in CL caused by L. braziliensis wit

136 e 3D created volumes, a method with previous proven high precision and accuracy.

137 We included patients with neuroimaging-proven ICH, available DNA and 6-month follow-up in an ob

138 The category of proven IFD can apply to any patient, regardless of wheth

139 Terminal uranium nitrides have so far proven impossible to isolate by photolysis of azides.

140 'Inflammatory axonal neuropathy' was proven in 14 (45%) of 31 sural nerve biopsies.

141 ft ionization capabilities of the FmuTP were proven in both ion modes.

142 The assay was proven in plasma from CRC patients and healthy donors, a

143 Delivery of gamma-ketobenzyl-d4TTPs was proven in T-lymphocyte cell extracts.

144 dneys, although further efficacy needs to be proven in the transplantation setting.

145 vity of ivermectin has not been consistently proven in vivo.

146 robial therapy is best indicated for culture-proven infection in pancreatic necrosis or when infectio

147 without urge incontinence; in the absence of proven infection or other obvious pathology.

148 Five of 6 cases (83%) had culture-proven infectious endophthalmitis (2 Candida glabrata, 2

149 SMA11) PET/MRI for initial staging of biopsy-proven intermediate- or high-risk PC, and 57 patients (m

150 Over the past 10 years, this distinction has proven its diagnostic value as well as its important pro

151 unotherapy by immune checkpoint blockade has proven its great potential by saving the lives of a prop

152 cancer targeted sequencing, and has already proven its use in a research laboratory environment.

153 patient outcomes in 178 patients with biopsy-proven LCCN from 10 centers in Europe and North America.

154 pharmacological approaches to treatment have proven less effective than previously thought, whereas s

155 Acetaminophen (APAP) is a proven lethal oral toxicant in reptiles but the physiolo

156 >=18 years) with primary or recurrent biopsy-proven, low-grade upper tract urothelial cancer (measuri

157 Forty-four patients (with pathologically proven lymphoma disease) underwent staging (18)F-FDG PET

158 ctive study included 51 patients with biopsy-proven MCNS recruited between November 2012 and October

159 ior left thigh lesion confirmed to be biopsy-proven melanoma.

160 There were 167 patients with biopsy-proven MMP who were seen at the Wilmer Eye Institute bet

161 in tears of 24% of patients with laboratory-proven moderate to severe COVID-19.

162 Twenty patients with histologically proven MPNST underwent post-treatment 1.5 T MRI.

163 icrobiome profiles of 171 Asians with biopsy-proven NAFLD and 31 non-NAFLD controls are analyzed usin

164 1557 multiethnic adult patients with biopsy-proven NAFLD enrolled into 4 different studies conducted

165 ncing was performed in a cohort of 83 biopsy-proven NAFLD patients and 13 patients with non-invasivel

166 Escherichia coli LPS in patients with biopsy-proven NAFLD, 25 simple steatosis (nonalcoholic fatty li

167 hundred and thirty-six patients with biopsy-proven NASH and bridging fibrosis or cirrhosis seen at I

168 Our aims were to determine whether biopsy-proven NASH impacts clinical outcomes in CHB patients an

169 y of 180 severely obese patients with biopsy-proven NASH, defined by the NASH clinical research netwo

170 ifferent superhyphenations were successfully proven: NP-HPLC-UV/vis/FLD-bioassay-RP-HPLC-UV/vis-ESI(-

171 een six to nine metres higher than today has proven particularly challenging(2).

172 Forty-nine patients with proven PCP and 126 patients without PCP were included.

173 mean age, 63 years; range, 18-95 years) with proven PE.

174 flavonoids and phenolics which have several proven pharmacological effects.

175 steroids and symptomatic management, without proven positive effects on long-term outcomes.

176 In this review, we discuss tools that have proven powerful in the investigation of nucleosome and c

177 here is no change in the classifications of "proven," "probable," and "possible" IFD, although the de

178 l between 21 February and 16 April 2020 with proven/probable COVID-19, 45 (96%) of whom fully recover

179 McfDNA-Seq had higher sensitivity for Proven/Probable non-Aspergillus IMI (sensitivity, 79%; 9

180 hey were positive in 84% of individuals with Proven/Probable pulmonary IMI.

181 lled 478 men aged 50 to 80 years with biopsy-proven prostate adenocarcinoma (International Society of

182 eneva, and Valencia) assessing the challenge-proven rate of coexistent peanut, tree nut, and/or sesam

183 ents (46% men) with single, sporadic, biopsy-proven RCC (median size +/- standard deviation, 2.8 cm +

184 time between ctHPVDNA positivity and biopsy-proven recurrence was 3.9 months (range, 0.37-12.9 month

185 ractice, and to consider extending access to proven rehabilitative therapies during the first year po

186 c allograft recipients at the time of biopsy-proven rejection.

187 tic genistein nanosuspension, was previously proven safe and effective against H-ARS when administere

188 Allergen immunotherapy is a proven, safe treatment for respiratory allergies.

189 Hydroxyurea has proven safety, feasibility, and efficacy in children wit

190 ivo pilot study involving 10 cases of biopsy-proven sarcoma and we propose a quantitative method to a

191 d to ICU, 67 patients (57.3%) presented with proven SARS-CoV-2 infection with severe ARDS requiring P

192 reater number of crops include the dearth of proven selectable marker gene-selection combinations and

193 s (NEC) (Bell stage II or more), and culture-proven sepsis.

194 ys and <17 years admitted with blood culture-proven sepsis.

195 ods development to improve implementation of proven services to reduce disparities in preventable con

196 scribes autopsy findings in 10 patients with proven severe acute respiratory syndrome coronavirus 2 (

197 multi (the only method to date that has been proven statistically consistent under GDL), while being

198 re desirable alternatives, but none have yet proven successful despite their ability to opsonize eryt

199 the fluorescence z-scan technique, which has proven successful for quantification of peripheral membr

200 Mindfulness and meditation techniques have proven successful for the reduction of stress and improv

201 ases and quarantining those in contact, have proven successful in bringing the epidemic under control

202 mophores using mutation strategies that have proven successful in native cupredoxins.

203 development of celiac disease have not been proven successful in randomized trials, but the quantity

204 nsals, and the bacterial RNA polymerase is a proven target for antibiotics.

205 Meanwhile, it is also proven that a timely and broad application of testing le

206 It has been proven that at increased temperature, sterols can underg

207 Although recent studies have proven that CE between two solids is primarily due to el

208 Here we have proven that newly synthesized chiral naphthalene diimide

209 r, glycidyl ester and trace metals) analyses proven that refined PPMO is safe to be consumed.

210 Previous studies using 2D images have proven the benefits of high-resolution image treatment i

211 amyloid-beta drives Alzheimer's disease has proven the subject of contemporary controversy; leading

212 equencing technologies, these platforms have proven their ability to resolve some of the most challen

213 hich can be obtained from fruit wastes, have proven their potential as plant immune-system elicitors.

214 These benefits have recently proven their usefulness in the operation of networked de

215 chemical (neutral, ionic, etc.) natures have proven their wide scope and opportunities.

216 Lithium-ion batteries have proven themselves to be indispensable among modern day s

217 rocess is a means to enable oral delivery of proven therapeutic antibodies as well as novel antibodie

218 ell-surface receptors and their ligands is a proven therapeutic strategy.

219 n of orthoretroviruses such as HIV-1 and are proven therapeutic targets.

220 APbBr(3) , and FAPbBr(3) single crystals, is proven through D/H NMR quantification, Raman spectroscop

221 olecular and biological information on genes proven to affect the outcome of pathogen-host interactio

222 Amantadine is currently the only drug proven to alleviate LID.

223 ogical assays to detect antibodies have been proven to be a great complement to the standard method o

224 s or NGP within polymer material science has proven to be a highly attractive strategy.

225 Inertial microfluidics has been proven to be a powerful tool for high-throughput, size-b

226 LP-1R) imaging with radiolabeled exendin has proven to be a powerful tool to quantify beta-cell mass

227 Single-serve machines have proven to be a rapid and convenient mechanism for prepar

228 In this sense, saliva has proven to be a strategic biofluid, owing not only to its

229 70s, the rechargeable alkali-ion battery has proven to be a truly transformative technology, providin

230 Moreover, it has proven to be a useful tool to construct organic luminoph

231 Aza-glycine has proven to be a valuable tool in the design of triple-hel

232 The propargyl electrophile has proven to be a versatile reactant when coupled with pall

233 but the elucidation of its genetic basis has proven to be a very challenging endeavor.

234 Some of the obtained compounds were proven to be active as inhibitors of PDE1 isoforms, with

235 Our workflow has been proven to be an effective alternative for current nanopr

236 The strawberry pulp has proven to be an effective alternative to increase the co

237 ponses, and blockade of this interaction has proven to be an effective immunotherapy for several diff

238 This approach has proven to be an efficient and cost-effective way to iden

239 Genomic selection (GS) has proven to be an efficient tool for predicting crop-rank

240 eams merged with theoretical approaches have proven to be an ideal tool to elucidate intrinsic struct

241 MPORTANCE High-temperature environments have proven to be an important source for the discovery of ne

242 However, near-infrared photodetection has proven to be challenging and, to date, the true potentia

243 he synthesis of sodium diazeniumdiolates has proven to be challenging due to hazardous reaction condi

244 e using top-down lithographic approaches has proven to be challenging due to poor structural control

245 tivation and gluco-metabolic homeostasis has proven to be complex and potentially inconsistent across

246 Statins have been proven to be cytotoxic to human cholangiocarcinoma cells

247 c autoimmune diseases; however, TNFalpha has proven to be difficult to drug with small molecules.

248 rs that undergo such flexible adaptation has proven to be difficult to establish using simplified mod

249 uman brain tissue samples, a source that has proven to be difficult to work with image-based spatial

250 Fluorescent staining with Nile red dye has proven to be effective at distinguishing microplastics f

251 une checkpoint inhibitors (ICIs), which have proven to be effective cancer therapies in many malignan

252 ORTANCE Adeno-associated viruses (AAVs) have proven to be effective gene transfer vectors.

253 e in treating mania, few antipsychotics have proven to be effective in bipolar depression.

254 diabetic retinopathy and its modulation has proven to be effective in curbing pathologic angiogenesi

255 ing Tmprss6 messenger RNA by Tmprss6-ASO was proven to be effective in improving IE and splenomegaly

256 The reaction has proven to be general, as R(3) PF(2) , R(2) PF(3) , and R

257 psies from patients, that were serologically proven to be HCV positive, were included in the current

258 Although the PubMLST scheme has proven to be highly discriminatory and informative, the

259 eduction of 3-substituted cyclobutanones was proven to be highly selective for the formation of cis a

260 d the energy expenditure per peptide bond is proven to be independent of the stability of the interme

261 differentiates the metastatic phenotype has proven to be more elusive.

262 Knowledge of these parameters has been proven to be of great clinical significance for the diag

263 gineered mouse models (GEMMs) of cancer have proven to be of great value for basic and translational

264 Rare coding variants have been proven to be one of the significant factors contributing

265 ver, the yields obtained from isolation have proven to be really low (<0.01%), greatly hindering the

266 erving geometric algorithms, which have been proven to be superior to the conventional algorithms bas

267 ence of transient provoking risk factors has proven to be the most important determinant of VTE recur

268 MicroPET/single-photon emission CT have proven to be two of the most translational modalities fo

269 nce then, these organometallic entities have proven to be uniquely effective in catalyzing an assortm

270 example, similar single-cell approaches have proven to be valuable for elucidating the behavior and v

271 animal cells, particularly in teleosts, has proven to be very efficient with regards to mutation rat

272 m 1 to 50 nM, the AuNPs modified Au chip was proven to clearly be a better analytical tool.

273 cally relevant therapeutic modality that has proven to compensate for the reduced therapeutic efficac

274 he hydrogels were successfully developed and proven to have antibacterial and anti-inflammatory prope

275 Notably, HOTAIR-sbid expression was proven to reduce cellular motility, invasiveness, anchor

276 Antiarrhythmic drugs have not proven to significantly improve overall survival after o

277 nal ganglion cells; lowering IOP is the only proven treatment strategy to delay disease progression.

278 uded 691 consecutive newly diagnosed, biopsy-proven, treatment-naive, D'Amico high-risk PCa patients

279 e coronavirus 2, has spread globally, and no proven treatments are available.

280 rome coronavirus 2, has spread globally, and proven treatments are limited.

281 1 in 4 therapeutic relationships eventually proven true.

282 en aortic root diameter was <50 mm, risk for proven type A dissection (0.4 events/1,000 patient-years

283 ands, traditional analytical techniques have proven unable to achieve this goal.

284 n aged 18 years or older with histologically proven, unresectable, locally advanced or metastatic, HE

285 no mid-trimester biomarkers have as yet been proven useful for prediction of PE.

286 oughput screening data, scaffold graphs have proven useful for the navigation and analysis of chemica

287 ses (AAVs) are dependoparvoviruses that have proven useful for therapeutic gene transfer; however, ou

288 tal complexes and organic chromophores, have proven useful in a range of pericyclic reactions, bond d

289 brain-wide activity patterns in humans have proven useful in distinguishing between disorder subtype

290 It has also proven useful in monitoring the response to treatment an

291 d measure of segmentation accuracy which has proven useful.

292 lls and three-dimensional (3D) spheroids was proven using the Pt-nanoelectrode.

293 d to study prokaryotes and protists and have proven valuable in identifying therapeutic targets, but

294 ve electron transfer dissociation (NETD) has proven valuable in sequencing oligonucleotide anions, pa

295 Regulating and encouraging the use of proven vehicle safety technologies in LMICs would have l

296 ents that underlie human-specific traits has proven very challenging.

297 ffects of PM(2.5), guide the use of the most proven/viable approaches, obviate the use of ineffective

298 d-related defense genes, which have recently proven vital in plant resistance to necrotrophic fungal

299 Tumor recurrence was defined as biopsy-proven vital tumor at the initial tumor site.

300 In a cytology-proven VRL case, all 15 vitreous isolated B cells were d