ライフサイエンスコーパス: proximal tubule

1 ls by inhibiting glucose reabsorption in the proximal tubule.

2 f impaired cystine reabsorption in the renal proximal tubule.

3 ce of GLUT2 in glucose absorption across the proximal tubule.

4 etabolic and transport processes seen in the proximal tubule.

5 basolateral exit pathway for creatine in the proximal tubule.

6 DDAH1 is expressed predominately within the proximal tubule.

7 CAII colocalizes with AQP1 in the renal proximal tubule.

8 returned to the systemic circulation by the proximal tubule.

9 E3-mediated NaHCO3 reabsorption in the renal proximal tubule.

10 orters and NHE3 interact functionally in the proximal tubule.

11 transcripts selectively expressed in native proximal tubule.

12 lucose cotransporters SGLT2 and SGLT1 in the proximal tubule.

13 y, toxicology, and pharmacology of the renal proximal tubule.

14 ugh the glomerulus and are reabsorbed by the proximal tubule.

15 he nucleus of injured human and mouse kidney proximal tubules.

16 -Dapa binding to the apical surface of early proximal tubules.

17 ephron derivatives, but disappears in mature proximal tubules.

18 however, it disappeared in mature NP-derived proximal tubules.

19 that it resides on basolateral membranes of proximal tubules.

20 rentiate into any nephron segments, not just proximal tubules.

21 compensatory increase in prourine uptake in proximal tubules.

22 d noted ectopic expression in P7 non-dilated proximal tubules.

23 well as clustering of macrophages around S1 proximal tubules.

24 espectively, which in pigs, localized to the proximal tubules.

25 dicator (GCaMP2) predominantly in the kidney proximal tubules.

26 anchors multiple membrane proteins in renal proximal tubules.

27 tion barrier and is endocytosed by the renal proximal tubules.

28 own as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chr

29 ture nephron structures and dedifferentiated proximal tubules after acute kidney injury.

30 We studied proximal tubules after ischemia-reperfusion injury (IRI)

31 n is most abundantly expressed in the kidney proximal tubule and collecting duct epithelia, where it

32 amine (DA) system is highly expressed in the proximal tubule and contributes to Na+ and blood pressur

33 ) intake increased Na(+) reabsorption in the proximal tubule and decreased it in more distal kidney t

34 rare juxtaglomerular cells, novel activated proximal tubule and fibroblast cell states, and previous

35 In the proximal tubule and in other tissues, MAP17 is known to

36 ) intake decreased Na(+) reabsorption in the proximal tubule and increased it in distal segments with

37 SGLT2 inhibitors are proximal tubule and osmotic diuretics that reduce volume

38 ed that pronephric nephrons require osr1 for proximal tubule and podocyte development.

39 exception of a glucose transporter along the proximal tubule and the H+-pump along the collecting duc

40 pivotal role in the early dysfunction of the proximal tubule and the subsequent renal repair.

41 ogenitor-like tubular scattered cells of the proximal tubules and by parietal epithelial cells of glo

42 eys of newborn mutant mice exhibited dilated proximal tubules and immature glomeruli, and the renal p

43 orm a heterogeneous population that includes proximal tubules and other types of cells.

44 in fewer numbers of autophagic cells in the proximal tubules and reduced ratio of the autophagy-rela

45 at Notch signaling promotes the formation of proximal tubules and represses the formation of distal t

46 t, Notch signaling promotes the formation of proximal tubules and represses the formation of distal t

47 uced apoptosis in microperfused Slc27a2(-/-) proximal tubules and Slc27a2(-/-) or FATP2 shRNA-treated

48 at epithelial cell plasma membranes in renal proximal tubules and thin descending limb of Henle.

49 yo-inositol oxygenase (MIOX) is expressed in proximal tubules and up-regulated in the diabetic state.

50 tosis, were deleted specifically from kidney proximal tubules and used this model to examine renal ap

51 production (e.g. ectopic Ccl2 in non-dilated proximal tubules), and augmented hedgehog signaling, fea

52 o SGLT2 in the apical membranes of the early proximal tubule, and is subsequently reabsorbed into blo

53 lized with the endocytic receptor megalin in proximal tubules, and compared with wild-type mice, mega

54 containing cells characterized as podocytes, proximal tubules, and distal tubules in an additional 10

55 stering of macrophages around S1 segments of proximal tubules, and full renal protection required bot

56 al tubulointerstitial disease resulting from proximal tubule antigen-specific antibodies and immune c

57 in 1-positive cells of the S3 segment of the proximal tubule, aquaporin 1-negative cells of the thin

58 Furthermore, proximal tubules are predisposed to become cystic after

59 own that double knockout of Bax and Bak from proximal tubules attenuated renal tubular cell apoptosis

60 the presence of vacuoles, nuclear count, and proximal tubule brush border integrity, which was valida

61 at luminal surface expression of AQP1 in the proximal tubule brush border membrane is regulated in re

62 onstitutively enhanced AQP1 abundance in the proximal tubule brush border membrane.

63 tubular Na(+) reabsorption increased in the proximal tubule but decreased in the distal nephron beca

64 tubular Na(+) reabsorption decreased in the proximal tubule but increased in distal segments with lo

65 rters detected in the apical membrane of the proximal tubule but not detected in other organs likely

66 g beta-catenin were able to form presumptive proximal tubules but that they failed to further develop

67 rminal Sepp1 forms are taken up in the renal proximal tubule by another receptor, megalin.

68 indicates that hepcidin is reaborbed in the proximal tubules by megalin dependent endocytosis.

69 nd subsequent reabsorption by the downstream proximal tubule, causing lipoapoptosis.

70 ed a critical role of adenosine generated by proximal tubule CD73 expression in abrogating IRI.

71 2 (GLUT2) during diabetes may lead to renal proximal tubule cell (RPTC) injury, inflammation, and in

72 The results demonstrate a primary renal proximal tubule cell AT(2)R natriuretic defect in SHR th

73 ectively, these findings indicate that renal proximal tubule cell CB1R contributes to the pathogenesi

74 In a renal proximal tubule cell line, either pharmacologic or genet

75 ules and Slc27a2(-/-) or FATP2 shRNA-treated proximal tubule cell lines compared with wild-type or sc

76 Fourteen different proximal tubule cell lines, representing six species, we

77 Using 2D and 3D human proximal tubule cell models, we show that indoxyl sulfat

78 n also reversed the corresponding protective proximal tubule cell phenotype in injured proximal tubul

79 el in mesangial cells, and identification of proximal tubule cell populations defined by pathogenic e

80 educed amounts of megalin and cubilin at the proximal tubule cell surface in Rab38 knockout versus co

81 ve proximal tubule cell phenotype in injured proximal tubule cell-specific ADAM17 knockout mice.

82 Moreover, the finding that proximal tubule cell-specific amphiregulin knockout mice

83 soluble amphiregulin into knockout mice with proximal tubule cell-specific deletion of amphiregulin's

84 unilateral ureteral obstruction in mice with proximal tubule cell-specific knockout of amphiregulin.

85 ed NHE3 expression (-50+/-9%) in human renal proximal tubule cells (hRPTCs).

86 man INPP5B insertion, and primary culture of proximal tubule cells (mPTCs) derived from OcrlY/- kidne

87 daily from the glomerular filtrate by kidney proximal tubule cells (PT), requiring ferrireductase act

88 ct of catalase (Cat) overexpression in renal proximal tubule cells (RPTCs) on nuclear factor erythroi

89 ort, and increased oxidative stress in renal proximal tubule cells (RPTCs).

90 Human renal proximal tubule cells (RPTECs) were used to characterize

91 undant levels of APOL1 mRNA were observed in proximal tubule cells and glomerular endothelial cells,

92 closporine A (CsA) treated and control human proximal tubule cells and identified mRNAs undergoing ac

93 characterizes the development of atrophy in proximal tubule cells and may contribute to the renal pa

94 ke of fluorescently labeled NEFA in cultured proximal tubule cells and microperfused rat proximal tub

95 We studied EGFR activation in proximal tubule cells and primary tubular cells isolated

96 During recovery by regeneration after AKI, proximal tubule cells can fail to redifferentiate, under

97 Cultured proximal tubule cells deficient in Nherf1 and proximal t

98 that specific deletion of CB1R in the renal proximal tubule cells did not protect the mice from obes

99 In conclusion, dedifferentiated proximal tubule cells effect proximal tubule repair, and

100 e expression profiles in nondiseased primary proximal tubule cells from black patients revealed that

101 n and IL-1beta processing) in isolated renal proximal tubule cells from WT mice whereas these increas

102 Here, we report that proximal tubule cells in kidneys sense elevated endogeno

103 YAP1 to induce sustained EGFR activation in proximal tubule cells in vitro.

104 stained activation of EGF receptor (EGFR) in proximal tubule cells is a hallmark of progressive kidne

105 Compared with primary renal proximal tubule cells isolated from KIM-1Deltamucin mice

106 Differentiated proximal tubule cells showed upregulation of specific ge

107 um cross-talk is further studied by exposing proximal tubule cells to hyperglycemic conditions and mo

108 In vitro, exposure of proximal tubule cells to the inflammatory cytokines IFN-

109 on the apical brush-border membrane of 786-O proximal tubule cells within the OOC surface, and the re

110 brainstem(4-6) and pH homeostasis by kidney proximal tubule cells(7,8).

111 reach the primary filtrate, are captured by proximal tubule cells, and are endocytosed.

112 Primary cilia were elongated in proximal tubule cells, collecting duct cells and parieta

113 In AQP1-transfected, cultured proximal tubule cells, fluid shear stress or the additio

114 t age-associated lysosomal defects in kidney proximal tubule cells, in the absence of frank CNS patho

115 location to apical plasma membranes of renal proximal tubule cells, internalization/inactivation of N

116 ating that acutely injured, dedifferentiated proximal tubule cells, rather than fixed tubular progeni

117 and wild-type controls, as well as isolated proximal tubule cells, to two different AKI models (isch

118 substrate accumulation in cystinotic kidney proximal tubule cells.

119 pro-inflammatory cytokines in cultured human proximal tubule cells.

120 mitochondrial morphology and respiration in proximal tubule cells.

121 f mitochondrial respiration in human primary proximal tubule cells.

122 gial cells, glomerular endothelial cells, or proximal tubule cells.

123 h conditioned media from serum-starved mouse proximal tubule cells.

124 ne fully matched the transcriptome of native proximal tubule cells.

125 In the proximal tubule, claudins have a role in the bulk reabso

126 ephrogenesis and early kidney growth, single proximal tubule clones expanded, suggesting that differe

127 spicuous in the tubular basement membrane of proximal tubules, corresponding to deposits observed by

128 tein efflux-transporters (MRPs) in the renal proximal tubule could enhance this unwanted effect.

129 nce mainly attributed to a greater number of proximal tubule cysts.

130 s with ABBA disease who had a combination of proximal tubule damage, IgG-positive immune deposits in

131 nt of kidney dysfunction, and (d) attenuated proximal tubule damage.

132 AKI induced proximal tubule dedifferentiation, with a pronounced nep

133 Lastly, proximal tubule deletion of DRP1 after ischemia-reperfus

134 The proximal tubules demonstrate a corresponding up-regulati

135 a renal cystic model, ectopic p-Creb stained proximal tubule-derived cystic segments that lost the di

136 sent in pkd1-knockout and normal mice and in proximal tubule-derived, cultured pkd1-knockout cells.

137 In proximal tubule-derived, PC1-knock-out cells, adenylyl c

138 hat Par1a/b has a key role in glomerular and proximal tubule development, likely via modulation of No

139 a-catenin signaling plays a critical role in proximal tubule development.

140 Adult CLIC4-null proximal tubules display aberrant dilation.

141 with tamoxifen-induced Wnt1 expression from proximal tubules displayed interstitial myofibroblast ac

142 w-level transfection of the collecting duct, proximal tubule, distal tubule, interstitial cells, and

143 S), is predominantly presented in podocytes, proximal tubules, distal convoluted tubules, and the api

144 Compared with control proximal tubules, DN, FSGS, IgAN, and MPGN proximal tubu

145 hile measuring the cellular transcriptome of proximal tubule during repair.

146 characterized by cystine accumulation, renal proximal tubule dysfunction, and kidney failure.

147 lial cells, which were inhibited in diabetic proximal tubule EGFR-knockout mice (EGFR(ptKO)) or admin

148 impairment of which has a dramatic effect on proximal tubule endocytosis.

149 NBCe1-A is expressed in proximal tubule epithelia; its dysfunction causes the pl

150 NBCe1 protein in the basolateral membrane of proximal-tubule epithelia is the most probable cause of

151 generated a clonal immortalised human renal proximal tubule epithelial cell line (ciRPTEC) expressin

152 ation, and chromatin accessibility in kidney proximal tubule epithelial cells (PTECs) derived from su

153 ion of YAP (yes-associated protein) in renal proximal tubule epithelial cells (RPTC) in patients with

154 echanism that operates specifically in renal proximal tubule epithelial cells (RPTEC).

155 cecal ligation and puncture (CLP) and human proximal tubule epithelial cells (TEC; HK2) were exposed

156 and clonal behavior of fully differentiated proximal tubule epithelial cells after injury.

157 Kidney FATP2 localized exclusively to proximal tubule epithelial cells along the apical but no

158 ted tubular architecture is circumscribed by proximal tubule epithelial cells and actively perfused t

159 TRPM2 was localized mainly in kidney proximal tubule epithelial cells, and studies in chimeri

160 dneys, CLIC4 is specifically enriched in the proximal tubule epithelial cells, in which CLIC4 is impo

161 pressed at the basolateral membrane of renal proximal tubule epithelial cells, mediates the renal exc

162 ion were upregulated in diabetic mouse renal proximal tubule epithelial cells, which were inhibited i

163 Our 3D kidney tissue allows for coculture of proximal tubule epithelium and vascular endothelium that

164 The proximal tubule epithelium relies on mitochondrial funct

165 g EGF-like growth factor (hHB-EGF), in renal proximal tubule epithelium.

166 lin FLCs, ROS activated the STAT1 pathway in proximal tubule epithelium.

167 Mice with CD73 deletion in proximal tubules exhibited exacerbated IRI, comparable w

168 d displays nuclear expression in the hypoxic proximal tubules exhibiting high levels of autophagy.

169 albumin at concentrations that mimic apical proximal tubule exposure during glomerular injury reveal

170 RNA expression analyses revealed that kidney proximal tubules express transmembrane fatty acid transp

171 l perfusion rates in isolated, microperfused proximal tubules for 15 minutes.

172 ture microdissection to obtain glomeruli and proximal tubules from 98 human needle kidney biopsy spec

173 roximal tubule cells deficient in Nherf1 and proximal tubules from Nherf1-deficient mice exhibit aber

174 nduced NLRP3 inflammasome induction in renal proximal tubules from WT mice.

175 RL) and share the feature of impaired kidney proximal tubule function.

176 line transcriptomes to gene sets for various proximal tubule functions (sodium and water transport, p

177 We identified >17,000 genes in each proximal tubule group, including 145 G-protein-coupled r

178 l proximal tubules, DN, FSGS, IgAN, and MPGN proximal tubules had differential expression of 13, 14,

179 The proximal tubule has a remarkable capacity for repair aft

180 o antibodies to brush border antigens of the proximal tubule has been demonstrated experimentally and

181 e data suggest that glomerular podocytes and proximal tubules have different requirements for PIKfyve

182 ced cytotoxicity progression in human kidney proximal tubule (HK-2) cells.

183 tic receptor, is markedly upregulated in the proximal tubule in various forms of acute and chronic ki

184 d to only liver parenchymal cells and kidney proximal tubules in adulthood, commencing at E12.5 and E

185 oprinting method for creating 3D human renal proximal tubules in vitro that are fully embedded within

186 and displayed key functional aspects of the proximal tubule, including protein endocytosis and incre

187 sclerosis complex protein 1 (Tsc1) in renal proximal tubules induced strikingly enlarged kidneys, wi

188 of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis.

189 Proximal tubule injury can initiate CKD, with progressio

190 damage, and apoptosis, all of which preceded proximal tubule injury.

191 usion injury at these sites and new sites of proximal tubule injury.

192 expression of well-characterized markers of proximal tubule injury.

193 The proximal tubule is a particularly important site for age

194 ing number of studies suggest that the renal proximal tubule is a site of injury in diabetic nephropa

195 Transepithelial water flow across the renal proximal tubule is mediated predominantly by aquaporin-1

196 investigate whether Wnt ligand derived from proximal tubule is sufficient for renal fibrogenesis, we

197 ium glucose cotransporter SGLT2 in the early proximal tubule is the major pathway for renal glucose r

198 The secretion of organic solutes by the proximal tubules is an essential intrinsic kidney functi

199 whereas these increases were absent in renal proximal tubules isolated from P2X4 KO mice.

200 This damage occurs primarily by killing of proximal tubule kidney cells and mechanosensory hair cel

201 -hydrogen exchanger type 3 expression in the proximal tubule, leading to polyuria and osmotic diuresi

202 cement of remaining podocytes, activation of proximal tubule-like parietal epithelial cells identifie

203 og (Shh) in subsets of non-dilated P7 mutant proximal tubules (likely driving the stromal Gli express

204 pattern in which genes of the glomerular and proximal tubule lineages were either unchanged or upregu

205 ation of nearly 150 differentially expressed proximal tubule lncRNAs during fibrosis suggests they ma

206 AI1 protein was detected within cytoplasm of proximal tubules localized, for some of them, near foci

207 taining multiple renal lineages, such as the proximal tubule, loop of Henle, distal tubules, and podo

208 meaningful increases in sodium exit from the proximal tubule/loop of Henle.

209 K-52E cells confirmed low expression of many proximal tubule marker proteins.

210 rces differed substantially in expression of proximal tubule markers.

211 structural cytomorphology, and expression of proximal tubule markers.

212 e dinucleotide)-dependent deacetylase in the proximal tubule, may be involved in renal injury associa

213 iew that OAT1 plays a greater role in kidney proximal tubule metabolism and OAT3 appears relatively m

214 Here, we have created 3D vascularized proximal tubule models composed of adjacent conduits tha

215 This effect relies on increased proximal tubule NaPi-IIa expression secondary to decreas

216 We conclude that FATP2 is a major apical proximal tubule NEFA transporter that regulates lipoapop

217 ex, indicating the protective effects on the proximal tubule occur primarily through modulation of th

218 pared with the proximal tubule of males, the proximal tubule of females had greater phosphorylation o

219 scripts were differentially expressed in the proximal tubule of males versus females.

220 Compared with the proximal tubule of males, the proximal tubule of females

221 e model the interaction between cells in the proximal tubule of the kidney, free light chains, renal

222 reticulum stress, was more prominent in the proximal tubules of 15 obese patients compared with 16 n

223 criptomes of cells from the proximal and non-proximal tubules of healthy and fibrotic human kidneys t

224 g expression of NUPR1 in the nuclei of renal proximal tubules of injured human kidney allografts, but

225 directly alter phosphate uptake in cultured proximal tubule OK cells.

226 These engineered 3D proximal tubules on chip exhibit significantly enhanced

227 otein, glucose, or phosphate handling in the proximal tubule or with the presence of >/=2 of these ma

228 in-dependent and -independent endocytosis in proximal tubules, phenocopying what has been reported fo

229 s relative phosphate retention via increased proximal tubule phosphate reabsorption.

230 ing cell populations with characteristics of proximal tubules, podocytes and endothelium.

231 alin and cubilin, respectively, that mediate proximal tubule protein uptake.

232 every facet of life-requires that the renal proximal tubule (PT) adjust its rate of H(+) secretion (

233 Proximal tubule (PT) cells are critical targets of acute

234 fusion injury by directly activating S1P1 on proximal tubule (PT) cells, independent of the canonical

235 4alpha (Hnf4a) is a major regulator of renal proximal tubule (PT) development.

236 accumulate within epithelial cells, causing proximal tubule (PT) dysfunction and renal Fanconi syndr

237 Symptoms of LS include proximal tubule (PT) dysfunction typically characterized

238 they appear to be dispensable for mammalian proximal tubule (PT) function.

239 Cells lining the proximal tubule (PT) have unique membrane specialization

240 Cells lining the proximal tubule (PT) of the kidney are highly specialize

241 In the proximal tubule (PT) of the kidney, claudin-2 mediates p

242 nic cation transporters (OCTs) in the kidney proximal tubule (PT) participate in renal excretion of d

243 f impaired glomerular filtration or impaired proximal tubule (PT) reabsorption, or both.

244 concept that both glomerular filtration and proximal tubule (PT) reclamation affect urinary albumin

245 In vitro data indicates that the kidney proximal tubule (PT) transporters of uremic toxins and s

246 l model of protein reabsorption in the human proximal tubule (PT) using Michaelis-Menten kinetics and

247 g dysfunction of the cells lining the kidney proximal tubule (PT).

248 or reabsorption of transferrin (Tf) in renal proximal tubules (PTs).

249 The renal proximal tubule reabsorbs 90% of the filtered glucose lo

250 Targeted deletion of PKM2 from mouse proximal tubules recapitulated precisely the protective

251 edifferentiated proximal tubule cells effect proximal tubule repair, and we reveal an EGFR/FOXM1-depe

252 nital cataract, low IQ, and defective kidney proximal tubule resorption.

253 he in vivo role of these signaling events in proximal tubule responses to kidney injury has been diff

254 (211)At- 6: also showed uptake in renal proximal tubules resulting in late nephrotoxicity, highl

255 This comprehensive transcriptomic map of the proximal tubule revealed sexually dimorphic gene express

256 mmunoprecipitation of ETBR and GRK4 in renal proximal tubule (RPT) cells from both WKY and SHRs but w

257 Renal proximal tubule (RPT) cells from hypertensive (HT) Euro-

258 hesized that deletion of Hnrnpf in the renal proximal tubules (RPT) of mice would worsen systemic hyp

259 f F0F1-ATPase activity after injury in renal proximal tubules (RPTC).

260 expression of Kim1 and vimentin in scattered proximal tubule segments.

261 a, we present an example of the way in which proximal tubule-selective Dps nanocages can limit the de

262 Light microscopy of proximal tubules showed geographic isometric vacuolizati

263 dium reabsorption was not downregulated, and proximal tubule sodium reabsorption, measured by lithium

264 s the D1-like receptor from inhibiting renal proximal tubule sodium transport, neutralizing the natri

265 t of fenoldopam and its inhibitory effect on proximal tubule sodium transport.

266 induce inflammation and fibrosis, collected proximal tubule-specific and bulk cortex mRNA at day 5 o

267 exposure, cells fluxed and took up drugs via proximal tubule-specific apical or basolateral transport

268 y gene modules, and previously unappreciated proximal tubule-specific bidirectional lncRNA regulation

269 A novel proximal tubule-specific Ddah1 knockout (Ddah1(PT-/-)) m

270 Using genetic murine models, we found that proximal tubule-specific deletion of Drp1 prevented the

271 Proximal tubule-specific deletion of Egfr in Pten(ptKO)

272 Here, we demonstrated that mice harboring a proximal tubule-specific deletion of Pten (Pten(ptKO)) h

273 Compared with control animals, urine from proximal tubule-specific EXOC5-KO mice contained fewer E

274 We generated mice with proximal tubule-specific expression of an L10a ribosomal

275 A proximal tubule-specific TFEB-knockout mouse exhibited p

276 In current study, we found that a proximal tubules-specific DsbA-L knockout mouse (PT-DsbA

277 ailed to further develop into differentiated proximal tubules, suggesting that beta-catenin signaling

278 centric" paradigm and focus attention on the proximal tubule that by virtue of the high energy requir

279 injected hhep25 and no hepcidin staining in proximal tubules that lack megalin.

280 By inhibiting glucose reabsorption in the proximal tubule, these agents promote glycosuria, thereb

281 in each of 14 renal tubule segments from the proximal tubule through the inner medullary collecting d

282 e nanoparticle that can be targeted to renal proximal tubules through glomerular filtration.

283 G45 to be effectively effluxed out of normal proximal tubules through P-glycoprotein transporter whil

284 me carnitine acetyltransferase (CrAT) in the proximal tubules, thus limiting a primary mechanism to e

285 tly lengthy, we used an ex vivo model of the proximal tubule to determine the role of ATRAP in SIRT1

286 es can affect all tubular segments, from the proximal tubule to the collecting duct.

287 vealed the metabolic signatures of S1 and S2 proximal tubules to be distinct and resolvable at the su

288 We sought to identify the apical proximal tubule transporter that mediates NEFA uptake an

289 al mechanism by which "multispecific" kidney proximal tubule transporters exert distinct physiologica

290 tasis by reabsorbing filtered glucose in the proximal tubules via sodium-glucose cotransporters (SGLT

291 In the kidney, proximal tubule was enriched in humans (P=8.5E-5 for eGF

292 dium-hydrogen exchanger type 3 levels in the proximal tubule were dramatically reduced in Epac1(-/-)

293 endocytic receptor highly expressed in renal proximal tubules, where it mediates uptake of albumin an

294 A-AKR1A1 system is highly expressed in renal proximal tubules, where it transduces the activity of eN

295 l reabsorption is augmented by growth of the proximal tubule, which (alongside sodium-glucose cotrans

296 1393 is specifically expressed in the kidney proximal tubule, which is the site of renal glucose reab

297 proximal tubule cells and microperfused rat proximal tubules, with greater uptake from the apical su

298 enerated a novel mouse strain with inducible proximal tubule Wnt1 secretion.

299 heir reciprocal interaction were upstream of proximal tubule YAP activation in diabetic kidneys.

300 This study demonstrates that proximal tubule YAP-dependent paracrine mechanisms play