ライフサイエンスコーパス: proximity

1 oach with farmed and wild oysters sampled in proximity.

2 ese 6mA flanked regions are in close spatial proximity.

3 506, Glu568, and Asp571 are located in close proximity.

4 tuents that can host two Ni-H units in close proximity.

5 of topic similarity and a measure of social proximity.

6 cortical microstructure and cortico-cortical proximity.

7 m Promoter Capture Hi-C and immediate linear proximity.

8 to recruit BCR-ABL1 and JAK kinases in close proximity.

9 ng hydrogen bonds and halogen bonds in close proximity.

10 ive cell-cell communication based on spatial proximity.

11 %) of Lewis acids is attributed to the close proximity (1.2 nm) between photoredox and Lewis acid cat

12 humans, livestock and vermin living in close proximity; (2) frequent antibiotic misuse; and (3) insuf

13 conformational changes into local side chain proximity adjustments, a property not captured by tradit

14 Network proximity analysis was used to demonstrate that the calc

15 colonies in blueberries, possibly due to the proximity and abundance of almond pollen during bloom.

16 ramatically outperforms models using genomic proximity and can be used to determine the quantitative

17 s, bringing the reacting peptides into close proximity and increasing the reaction rate.

18 Our results indicate that the proximity and orientation for cysteine pairs at I409C/R4

19 t respiratory transmission is dominant, with proximity and ventilation being key determinants of tran

20 More exposures, closer exposure proximity, and more extensive index patient disease were

21 ver, current techniques to visualize spatial proximity are either limited by spatial resolution, dyna

22 hat conditioned threats encountered in close proximity are more resistant to extinction learning and

23 t sites in terms of their concentrations and proximities as well as their cooperativity in activating

24 anism if the diene termini are held in close proximity, as in cyclopentadiene.

25 d, with a pIC(50) >= 5.0, in a scintillation proximity assay (SPA) HTS at a lower hit rate and with a

26 sformations require metal and redox sites in proximity at interfaces; however, in traditional oxide-s

27 In this study, we exploited the proximity-based biotinylation approach to identify bindi

28 Proximity-based enhancement of suboptimal hairpin proces

29 Proximity-based in situ labeling techniques offer a uniq

30 We used a proximity-based ligation assay, BioID, to identify guani

31 Close proximity between cytotoxic T lymphocytes and tumour cel

32 The network-based proximity between drug targets and disease genes can pro

33 Here we evidence a striking proximity between IL-33(+) muscle mSCs and both large-fi

34 the stochastic processes that influence the proximity between microbial decomposers and organic matt

35 RRS1-R or RRS1-S involves effector-triggered proximity between their TIR domain and C termini.

36 We also noticed the proximity between this locus and naturally occurring gen

37 To address this gap, we used multiplexed proximity biotinylation (BioID) to generate an in situ,

38 One-minute proximity biotinylation captured candidate binding partn

39 as a major functional cluster of TMEM16K in proximity biotinylation proteomics analyses.

40 We use proximity biotinylation to identify the AC9 interaction

41 ependent protein interactome on the basis of proximity biotinylation, and applied it to distinct chro

42 pled residue pairs being in close structural proximity, both domain-swapped and nondomain-swapped ASI

43 complexes the Au(I) atoms are held in close proximity but beyond the distance typically observed for

44 we introduce chemical-crosslinking assisted proximity capture (CAP-C), a method that uses multifunct

45 ph-theoretical framework, the Corrected Gene Proximity (CGP) map to study the effect of the 3D spatia

46 nslator design based on the concept of split proximity circuit (SPC) to achieve both high sequence se

47 he average frequency of partner affiliation (Proximity, Contact, and Tail Twining) and infant carryin

48 he field, including multimetallic SACs, atom proximity control, and possible applications for multist

49 on allowed us to construct a two-dimensional proximity correlation map that defines the supramolecula

50 Root tips in close proximity could collectively exude high amounts of citra

51 iotinylation (BioID) to generate an in situ, proximity-dependent adhesome in mouse pancreatic fibrobl

52 Here we performed the unbiased proximity-dependent biotin identification (BioID) approa

53 Using a proximity-dependent biotinylation proteomics strategy, w

54 Proximity-dependent FRET could be monitored directly aft

55 Here we present proximity-dependent PAINT (PD-PAINT), a method for subdi

56 ffraction imaging of protein pairs, in which proximity detection is decoupled from optical resolution

57 introduced a new metric designated 'contact proximity deviation' that enumerates contact map changes

58 massive spiral galaxy, whose properties and proximity distinguish it from all known hosts.

59 is difficult on SDS-PAGE due to their close proximity during electrophoresis and poor sensitivity of

60 e fruitful potential of spin manipulation by proximity effect at the hybridized 2D material / ferroma

61 hensive understanding of the superconducting proximity effect observed in QAH-superconductor hybrid d

62 gely responsible for the observed long-range proximity effect.

63 Magnetic proximity effects are integral to manipulating spintroni

64 Anomalous proximity effects have been observed in adhesive systems

65 erials opens new possibilities for exploring proximity effects in van der Waals heterostructures(9-12

66 interact with their activators owing to the proximity effects, leading to a boost in biocatalytic pe

67 We report a proximity-enabled reactive therapeutics (PERx) approach

68 d by the interfacial CrI(3) layer, while the proximity exchange field is highly sensitive to the laye

69 A highly sensitive proximity extension assay was used for targeted profilin

70 n stage D (N=29) and stage C (N=12) HF using proximity extension assays.

71 Our analysis revealed that the proximity, flexibility and solvent exposure of the tyros

72 ic distance and use it to "correct" the gene proximity for cell type 3D specific arrangements.

73 mu) may also align two dsDNA ends into close proximity for synthesis.

74 ulations of the FRET data to account for the proximity FRET effect occurring in confined two-dimensio

75 volume of polytopic transmembrane proteins, proximity FRET, and rotational diffusion of fluorophore

76 on of features that preserve arbitrary-order proximity from a highly integrated, heterogeneous biolog

77 mbine long-read sequencing with a Hi-C-based proximity guided assembly to generate a 15.87 Mb assembl

78 Traffic proximity has been associated with adverse respiratory h

79 aneous sensing of temperature, pressure, and proximity has been developed.

80 these cell types, combined with their close proximity, has prevented characterization of individual

81 f phosphorylation, and activity dependent on proximity (i.e., linker length).

82 neutrophils and CD3(+) T cells were in close proximity in kidney and spleen.

83 Proximity in low-dimensional UMAP space identifies group

84 is needed on the number of residues in close proximity in space, in contrast to previous applications

85 tuning curves tend to be located in spatial proximity in the dOB.

86 s recruit the E3 ligase to the POI and cause proximity-induced ubiquitination and degradation of the

87 in human embryonic kidney cells to identify proximity interaction partners for GATA3, TCF7 (TCF1), S

88 (NHEJ), bringing two broken dsDNA ends into proximity is an essential prerequisite for ligation by X

89 Proximity is detected via the highly distance-dependent

90 Spatial proximity is often used as a proxy for the direct intera

91 o using receptor immobilization and enforced proximity, is based on lateral mobility of receptors and

92 Using domain-specific BioID proximity labeling and super-resolution imaging, we iden

93 ibes the use of TurboID and split-TurboID in proximity labeling applications for mapping protein-prot

94 Using a BioID proximity labeling approach, we show that SHCA exists in

95 composition within cellular structures using proximity labeling approaches but compensating for the d

96 tic study applying a variety of biotin-based proximity labeling approaches in several plant systems u

97 ly a few studies have reported on the use of proximity labeling in plants.

98 Proximity labeling is a powerful approach for detecting

99 Here we describe the integration of a proximity labeling method and quantitative mass spectrom

100 n previously described biotin ligase-related proximity labeling methods, such as BioID, enabling high

101 Unbiased detection through proximity labeling of transient protein interactions in

102 To this end, enzymatic proximity labeling platforms are broadly applied for map

103 ps in the field for designing and optimizing proximity labeling proteomic experiments.

104 Most proximity labeling techniques use a promiscuous biotin l

105 verages CRISPR-CasRx-based RNA targeting and proximity labeling to identify binding proteins of speci

106 CN-binding peptides, in vivo SLiM-dependent proximity labeling, and in silico modeling of motif dete

107 ased on CRISPR interference and biotin-based proximity labeling, respectively.

108 Using APEX2-based proximity labeling, we reveal the protein composition of

109 Proximity-labeling and super-resolution microscopy show

110 Here, via analysis of a proximity-labeling proteomic profile of INM-associated p

111 , lambda(o) was near zero at close electrode proximity, lambda = 0.11 eV at a distance of ~4 angstrom

112 This anatomic proximity led us to investigate functional changes in mi

113 We used proximity ligation and affinity purification proteomics

114 ulatory subunit) and p52Shc was evaluated by proximity ligation and coimmunoprecipitations.

115 murine ventricular myocytes, immunoblotting, proximity ligation as-says, and nitric oxide imaging, we

116 s result with biochemical assays and use the proximity ligation assay (PLA) to identify oligomeric be

117 -3 proteins with PTEN was assessed using the proximity ligation assay and by co-immunoprecipitation.

118 Proximity ligation assay demonstrated interaction betwee

119 Finally, we modified a proximity ligation assay for tissue sections and found t

120 Proximity ligation assay showed close interaction betwee

121 Here we introduce SYNPLA (synaptic proximity ligation assay), a synapse-specific, high-thro

122 se brain, as evidenced by co-immunostaining, proximity ligation assay, co-immunoprecipitation, and pu

123 Here, using proximity ligation assay-based chromatin assembly assays

124 ze and cointeract with MMP2/MMP14 by in situ proximity ligation assay.

125 isoforms was observed by immunostaining and proximity ligation assay.

126 Proximity ligation assays established that ANO1, TRPV1,

127 Proximity ligation assays showed co-localization of endo

128 ometry followed by coimmunoprecipitation and proximity ligation assays to identify and validate two k

129 in vivo Proteomics of nascent chromatin and proximity ligation assays with newly replicated DNA reve

130 ioluminescence resonance energy transfer and proximity ligation assays, we found that CXCR4 heteromer

131 wn by fractionation, immunofluorescence, and proximity ligation assays.

132 erse digital droplet immunoassay (ddIA) uses proximity ligation to remove the need for wash steps and

133 re captured by biotin-dATP incorporation and proximity ligation, followed by gentle shearing, ChIP, b

134 treatment were determined by immunoblotting, proximity ligation, replicon DNA replication and whole v

135 RADICL-seq is a proximity ligation-based methodology that reduces the bi

136 Modern proximity-ligation assays, like HiChIP and ChIA-PET, fac

137 Addition of proximity-ligation sequencing enabled near chromosome-le

138 edially to the subthalamic nucleus, in close proximity, mainly anterolaterally, to fibers beneficial

139 The Corrected Gene Proximity map is a map of the 3D structure of the genome

140 the CGP map is a weighted network, the gene proximity map, whose weights are based on the contact fr

141 Network proximity measurement revealed underlying pathogenesis f

142 ules that endow new functions to enzymes via proximity-mediated effect are emerging.

143 Ps) in MAs, although they lacked the spatial proximity necessary for their activation by TRPV4(EC) ch

144 h to define TRIM9 and TRIM67 protein-protein proximity network in developing cortical neurons and ide

145 ble approach is to place a studied system in proximity of a metal, which induces additional screening

146 le pulldown, we revealed that increasing the proximity of adjacent kinase domains, rather than format

147 ificity, and these pMEIs are enriched in the proximity of affected genes and in regulatory elements.

148 lar applicability by visualizing the spatial proximity of alpha- and beta-tubulin in microtubules usi

149 Here, we demonstrate the proximity of ARF1*GTPs in vivo by fluorescence resonance

150 Unfortunately, the close physical proximity of both membranes poses a severe experimental

151 cs(6,7) to track hundreds of proteins in the proximity of Ca(V)1.2.

152 lecular dynamics simulations suggest a close proximity of clobetasol to the heme in CYP3A5 but not in

153 Plants detect proximity of competitors through reduction in the ratio

154 The close proximity of EBV episomes and the super enhancers that a

155 associated with increased numbers or greater proximity of enhancer regulatory elements near the gene.

156 Previous research suggests that the proximity of individuals in a social network predicts ho

157 mission intensity, duration of exposure, the proximity of individuals, and the degree of mixing.

158 sulin secretion (GSIS) in beta cells are the proximity of insulin granules to the plasma membrane and

159 d lung cancers, was strongly enriched in the proximity of Lrp6.

160 This observation shows that the mutual proximity of molecular or atomic species is sufficient t

161 in the relative orientation and the physical proximity of molecules in real-time.

162 al molecules is not compromised by the close proximity of neighbors.

163 The physical proximity of nociceptors and immune cells allows for dir

164 elatively moderate pH of the Sakurajima ash, proximity of our mesocosms to propagule sources, and the

165 reproduction among years and increasing the proximity of potential mates after a fire.

166 utations that occur on PTMs and in the close proximity of PTM sites with functional impact.

167 ular width between the macula center and the proximity of RNFL defect, and angle beta (+c) is the sum

168 Approaches such as orientation and proximity of substrate, transition-state stabilization,

169 dulates synaptic vesicle localization in the proximity of the active zone membrane independent of Mun

170 tes that, binding to the regulatory sites in proximity of the antenna region, NADH acts as a positive

171 The proximity of the EF domain to the active site suggests t

172 ic signatures, and identifies a locus in the proximity of the gene encoding tyrosine kinase FYN as th

173 We propose that spatial proximity of the homologous centromere DNA sequences fac

174 s can also select any protein residue in the proximity of the ligand to inspect its interactions with

175 n of support-generated hydronium ions in the proximity of the metal particles.

176 Formula: see text]/pulse was measured at the proximity of the moderator exit surface.

177 cio-economic conditions such as the size and proximity of the nearest market, poor governance and the

178 The close proximity of the Rab33B and WIPI2b binding sites might f

179 ivated by emerging data showing the physical proximity of the spliceosome to Pol II, we surveyed the

180 hich is partially localized at the ER in the proximity of the translocon.

181 were older age, greater tumor thickness, and proximity of the tumor to the foveal avascular zone.

182 ing environments of their micropores and the proximity of their Bronsted acid sites.

183 edding of the vertices of the network, where proximity of vertices is interpreted as the likelihood o

184 results show that network-based drug-disease proximity offers a novel perspective into a drug's thera

185 es such as varying intensities or geographic proximities, often exist, enabling the creation of an em

186 The IL1A and IL1B genes lie in close proximity on chromosome 2 near the gene for their natura

187 , independent probes to be arranged in close proximity on the same substrate.

188 total presubiculm correlated negatively with Proximity (r = - 0.88) and Contact (r = - 0.91), but not

189 onnectome is global and linked to functional proximity rather than anatomical distance to tumour regi

190 rated proteome and suggests that the spatial proximity resulting from phase separation reduces the re

191 de a guidance for future attempts to achieve proximity screening of many-body phenomena in two-dimens

192 by either visual assistance (20-30%) or the proximity sensation (60-70%), without additional process

193 The proximity sensation is two-to-three times more effective

194 ork (WBN), which enables simultaneous direct proximity sensing, high-resolution tracking, and long-ra

195 Currently available proximity-sensitive assays for in situ imaging of such i

196 vide heating but also perform as thermal and proximity sensors, and orderly aligned metal fibers that

197 We used an automated proximity system to longitudinally monitor several leks

198 e (HSC70) clients using a ubiquitin-mediated proximity tagging strategy and show that, despite their

199 Lrp6 proximity targets were identified by mass spectrometry,

200 ergence of 'portal hypertension theories' of proximity, throughput, and recruitment.

201 - and post-replacement at sites with varying proximities to the WWTP.

202 data obtained onboard commercial aircraft in proximity to 36 airports worldwide, as part of the Compr

203 Proximity to a confining clay layer that expels organic

204 flavonoid binds SARS-CoV-2 Mpro in the close proximity to a conserved cysteine (Cys44), which is hype

205 Living in close proximity to a greener environment at birth has a protec

206 Proximity to a major roadway, a composite measure of hom

207 rate high concentration of hydroxide ions in proximity to a metal electrode.

208 rrays of particles are created in near-field proximity to a mirror.

209 form that juxtaposes a human mammary duct in proximity to a perfused endothelial vessel.

210 Physical proximity to a traumatic event increases the severity of

211 00 potential ANT target genes based on their proximity to ANT binding sites and differential expressi

212 cells are preferentially localized in close proximity to blood vessels in physiological human dental

213 e intracellular CD277, created pAg-dependent proximity to BTN2A1, enhanced cell-cell conjugate format

214 ing on fibroblasts was associated with their proximity to CD73(+) myeloid cells in tumor tissue.

215 Mountains, manifest a peculiar mitochondrial proximity to central-eastern Europeans, mainly due to ha

216 Unexpectedly, CN shows SLiM-dependent proximity to centrosomal and nuclear pore complex (NPC)

217 gnitive inhibition impairments in C9+ and of proximity to clinical conversion.

218 neurons) in the lamina propria are in close proximity to clusters of ILC3 that selectively express V

219 s unclear if enough farmland exists in close proximity to each city for the distribution of compost.

220 se and disrupt protein residues within close proximity to each other and autocatalytic cleavage sites

221 s who live together remain in close physical proximity to each other and regularly engage in reciproc

222 ) receptor IP(3)R1 were often found in close proximity to each other.

223 h the reactive groups are brought into close proximity to enable catalysis.

224 haemoglobin alpha (Hbalpha) within nanometer proximity to eNOS limits TRPV4(EC) -eNOS signalling in M

225 me to completion significantly predicted the proximity to estimated clinical conversion from presympt

226 We investigated whether residential proximity to flaring from OGD was associated with shorte

227 luenced by the TEs' chromosomal position and proximity to genes.

228 Proximity to higher production OGD in California was ass

229 cubitril/valsartan varies in relation to the proximity to hospitalization for HF among patients with

230 eening and treatment of individuals in close proximity to index cases, also known as reactive case de

231 inhomogeneous central spin models using the proximity to integrable lines with exact dark eigenstate

232 etermined that Basigin is expressed in close proximity to integrin at the glial membrane, and that ex

233 disease risk variants appear to be in close proximity to known Parkinson's disease genes and lysosom

234 xisting methods: first, we no longer rely on proximity to link a locus to a gene which has shown to b

235 ss COVID-19 cases and deaths associated with proximity to livestock plants to be 236,000 to 310,000 (

236 enteric nervous system (ENS) exists in close proximity to luminal bacteria.

237 ere visible or invisible, depending on their proximity to masks.

238 emonstrates that Mic19 is generally in close proximity to Mic60, whereas the spatial coordination of

239 This suggests that proximity to microtubule tracks may be a key regulator o

240 stigate the relationship between residential proximity to OGD and birth outcomes in California.

241 junctions holding lipid structures in close proximity to one another throughout the tissue.

242 mosaics, in which like-type neurons minimize proximity to one another.

243 ting that GFAP may be an important marker of proximity to onset, and helpful for forthcoming therapeu

244 del is repeatedly criticized for its lack of proximity to original patient tumors.

245 as positively associated with natural cover, proximity to primary bear range and lower road density.

246 cle cells of the muscularis mucosa, in close proximity to proliferative crypts, are a source of WNT a

247 itor dielectrics or gate insulators in close proximity to qubit devices.

248 ities in point-source capture and geographic proximity to relevant sinks, specifically enhanced oil r

249 Schools in proximity to roadways expose students to traffic-related

250 previously reported to recognize epitopes in proximity to RTA's active site.

251 H. pylori resides in close proximity to S-phase cells in the gastric mucosa of gast

252 Residence time significantly increased with proximity to shallow seamounts, while dive depth increas

253 s signal demonstrated that variants in close proximity to SNCA and CTSB (encoding cathepsin B) are th

254 d potential drugs showed a wide variation in proximity to SSc-associated genes and distinctive proxim

255 With close proximity to steady-state immune cells and innervating n

256 myocytes, a Na(V)1.5 subpopulation in close proximity to subjacent subsarcolemmal mitochondria; we f

257 as been postulated, metabolite production in proximity to taste receptors could reach relatively high

258 of carbonate species distinguished by their proximity to the amine and identifiable based on (13)C c

259 s around the perimeter of podosomes in close proximity to the basolateral plasma membrane, and phosph

260 Here, we report that KLHL14 is in close proximity to the BCR in the endoplasmic reticulum of MCD

261 a second sphere phenylalanine positioned in proximity to the bound substrate, the catalytically impa

262 the nanowire above the Fermi level in close proximity to the conduction band.

263 s of droplet shrinking were sensitive to the proximity to the dissolution ("boiling") temperature of

264 damaged sites that are brought into physical proximity to the DSB.

265 bserved when the dispersed phase is in close proximity to the electrode surface.

266 The hepatocyte cell line depicted closer proximity to the embryo data.

267 Mic60, self-assembles and localizes in close proximity to the ER through an independent mechanism.

268 of point mutations due to kataegis in close proximity to the genomic breakpoints and with the activa

269 nd presence of stabilizing residues in close proximity to the glycation sites.

270 tation towards the target lysine residues in proximity to the H2A alpha1-extension helix, which plays

271 n studies identified ChREBP binding sites in proximity to the HB-EGF gene.

272 otein-coding genes as well as genes in close proximity to the identified noncoding regions are involv

273 re interaction domain is positioned in close proximity to the inner membrane leaflet, enabling the re

274 Due to the often close proximity to the inner-segment mitochondria, they may, t

275 for cysteine pairs at I409C/R410C, in close proximity to the lateral windows, and L402C/L403C, at th

276 pper liver segments (II, IVa, VII, or VIII); proximity to the liver capsule, distance from the skin >

277 interface mostly inaccessible because of its proximity to the membrane.

278 on expression of this fusion protein, DNA in proximity to the POI is methylated by Dam and can be sel

279 ed by small molecules that bring a kinase in proximity to the protein-of-interest.

280 mity to SSc-associated genes and distinctive proximity to the SSc-relevant pathways, depending on the

281 They reveal a close proximity to the structure directing agent (SDA), that i

282 odynamic performance varies with morphology, proximity to the substrate, and angle of attack (inclina

283 mainly observed in the mitochondria in close proximity to the synapses.

284 ency and sound pressure levels, not temporal proximity to the US, are the key factors underlying SCS-

285 V gene segments in similar three-dimensional proximity to their distal recombination center composed

286 igits 2 to 9, and stimuli presented in close proximity to these digits, due to perceptual distortion.

287 E receptor FcepsilonRIalpha and are in close proximity to TICs.

288 croscopy, we determined that Vpu is in close proximity to Tim-3 and alters its subcellular localizati

289 and ALOX15), M2 predominance over M1 and M2 proximity to tumor cells was observed, especially at IM.

290 likely transcribed as a consequence of their proximity to upstream TSSs on the opposite strand.

291 in-orbit coupling induced in the TBG via its proximity to WSe(2).

292 vasive monitoring of changes in cell-to-cell proximity, transcription, translation, protein folding,

293 sites, coding-region variants, and SNP-gene proximity, we were able to identify 1,731 potential ance

294 ampus integrates memories formed in temporal proximity, while the lateral striatum integrates memorie

295 docking-site configuration to detect spatial proximity with high sensitivity, low false-positive rate

296 several reasons: high-volume clinics, close proximity with patients, equipment-intense clinics, and

297 n both their number of amino acids and their proximity with the supported lipid bilayer.

298 wing that the GTPase and kinase are in close proximity, with the GTPase closer to the microtubule sur

299 Tyrosine proximity within TG is thought to enable the coupling re

300 owth of metallic nanoparticles, at nanoscale proximity, within a perovskite oxide lattice as well as