ライフサイエンスコーパス: proximodistal

1 biases in planar polarity: mediolateral and proximodistal.

2 atal disease; ALO monolayers with well-mixed proximodistal airway components recapitulated both.

3 s Bmp signaling, which in turn helps mediate proximodistal and anteroposterior patterning of Hgf expr

4 musculature, particularly in relation to the proximodistal and dorsovental axes.

5 mesenchymal signals expressed in restricted proximodistal and dorsoventral domains of the developing

6 of morphogenetic events involving outgrowth, proximodistal and dorsoventral patterning, and epithelia

7 srupted and the prominence failed to undergo proximodistal and mediolateral expansion.

8 stem with three distinct axes: dorsoventral, proximodistal and mediolateral.

9 my: both cell types were found all along the proximodistal and radial axes of the subiculum and all i

10 ls first acquire different identities in the proximodistal and radial axes.

11 development occurs along three cardinal axes-proximodistal, anteroposterior and dorsoventral-that are

12 of the embryo develops from conversion of a proximodistal asymmetry established in the primitive end

13 ely that ectodermal Dll/Dlx expression along proximodistal axes originated once in a common ancestor

14 Dlx expression in the arches patterns their proximodistal axes.

15 imb patterning along the anteroposterior and proximodistal axes.

16 mechanisms regulating patterning along their proximodistal axis (base to tip) are thought to be quite

17 ortant for the rate of cell growth along the proximodistal axis and for cell cycle duration in epider

18 re microdissected into fractions along their proximodistal axis and thoroughly dissociated for tropho

19 and Decapentaplegic, and how these define a proximodistal axis as limbs appear.

20 osophila are divided into segments along the proximodistal axis by flexible structures called joints.

21 l for patterning the limb skeleton along the proximodistal axis during embryonic development.

22 lements in Drosophila limbs and can initiate proximodistal axis formation when expressed ectopically.

23 rict barrier to cellular migration along the proximodistal axis in the early stage 19-22 limb buds.

24 spatial selectivity is comparable along the proximodistal axis in this experimental protocol.

25 ent is essential for converting the existing proximodistal axis into an anteroposterior axis.

26 a wing imaginal disc is subdivided along the proximodistal axis into the distal pouch, the hinge, the

27 proliferation and differentiation along the proximodistal axis is crucial for lung organogenesis.

28 t of mossy fiber synaptic strength along the proximodistal axis is mirrored by an increasing gradient

29 atterning was co-opted for patterning of the proximodistal axis of appendages of bilaterian animals.

30 dicate that the functional segregation along proximodistal axis of CA1 is not of the amount of spatia

31 ts that neurons in different areas along the proximodistal axis of CA1 of the hippocampus will be fun

32 tion is differentially represented along the proximodistal axis of CA3.

33 scripts, proteins, and metabolites along the proximodistal axis of caudal fins of uninjured and regen

34 We find that Dll is expressed along the proximodistal axis of developing polychaete annelid para

35 proliferation and differentiation along the proximodistal axis of epithelial, mesenchymal and endoth

36 proliferation and differentiation along the proximodistal axis of epithelial, mesenchymal and endoth

37 A proximodistal axis of origin in CA1 and distoproximal ax

38 xpression was typically restricted along the proximodistal axis of petals and stamens, indicating the

39 es in the state of differentiation along the proximodistal axis of the allantois were further borne o

40 c gives rise to three main regions along the proximodistal axis of the dorsal mesothoracic segment: t

41 n sculpts a morphogenetic gradient along the proximodistal axis of the early leaf primordium, thereby

42 tion of growth is maintained parallel to the proximodistal axis of the flower, irrespective of change

43 es were observed in final position along the proximodistal axis of the host allantois.

44 expression of Dlx genes acts to pattern the proximodistal axis of the pharyngeal arches during verte

45 radients of positional information along the proximodistal axis of the pupal wing.

46 kable effect that it has on respecifying the proximodistal axis of the regenerating limb so that seri

47 tion of positional values for patterning the proximodistal axis of the vertebrate limb has been quest

48 Limbs have a proximodistal axis that usually is not apparent early in

49 the ectoderm, and they then expand along the proximodistal axis to generate the narrow, tight morphol

50 that stat92E activity is regulated along the proximodistal axis to pattern this axis and control the

51 ore is required for more than induction of a proximodistal axis upon which homothorax superimposes an

52 The proximodistal axis was the subject of experimental and t

53 that the Prod 1 promoter is regulated on the proximodistal axis, and that Meis homeoproteins directly

54 bud normally exists in a gradient across the proximodistal axis, but uniformly across the anteroposte

55 the formation of distal structures along the proximodistal axis, or by overexpression of dominant-neg

56 an altered patterning of the leaf along the proximodistal axis, or in complete duplication of the de

57 at form a 'hidden' prepattern along the leaf proximodistal axis, potentiating the unique expression p

58 e fins possess distinct patterning along the proximodistal axis, reflected in the location of ray bif

59 mbers in the mutant were increased along the proximodistal axis, showing pinnate pentafoliate leaves

60 d by cell elongation and alignment along the proximodistal axis, which require actomyosin, but not mi

61 irect expansion, within the pouch, along the proximodistal axis.

62 gless signalling sequentially elaborates the proximodistal axis.

63 to become asymmetrically distributed on the proximodistal axis.

64 ertebrate embryonic limb outgrowth along the proximodistal axis.

65 iscreet domains of gene expression along the proximodistal axis.

66 shortening with skeletal outgrowth along the proximodistal axis.

67 behavioral role of CA3 subregions along the proximodistal axis.

68 idermis differentiation is uniform along the proximodistal axis.

69 erior digit patterning and shortening of the proximodistal axis.

70 l requirement for Dll and position along the proximodistal axis; how this may relate to the generatio

71 iking heterogeneity along the transverse, or proximodistal, axis of CA3 in spatial encoding and memor

72 mi) proteins do not properly localize to the proximodistal boundaries of cells.

73 were no differences in remapping across the proximodistal CA1 axis.

74 racterized by distinct spectral profiles and proximodistal CA1 gradients of theta and 20-40 Hz power

75 s, we provide detailed quantification of the proximodistal coherence of theta activity in the dorsal

76 Proximodistal development of median fins occurs beneath

77 ducer and activator of transcription in wing proximodistal development.

78 Thus, the identification of proximodistal differences in levels of RNAs, proteins, a

79 Current flows in a proximodistal direction within the limb stump and is ass

80 Thus, the proximodistal domains are patterned in sequence and show

81 roups located at restricted dorsoventral and proximodistal domains of the limb.

82 ila appendages are subdivided into different proximodistal domains specified by specific genes, and t

83 Plants leaves develop proximodistal, dorsoventral (adaxial-abaxial), and medio

84 Lateral organs are patterned along proximodistal, dorsoventral and mediolateral axes.

85 However, proximodistal epithelial differentiation is disrupted by

86 and extending gradually until it covers the proximodistal extent.

87 o a progressively limited range of potential proximodistal fates.

88 l transport decreased and LVT increased in a proximodistal gradient along the axon, but together they

89 embryonic limb in vertebrates is driven by a proximodistal gradient of cell movement, with WNT and FG

90 panding maize adult leaf displays a dynamic, proximodistal gradient of cuticle development, from the

91 t the headfold-stage allantois may contain a proximodistal gradient of differentiation, and raise int

92 In young axons, activated JNK forms a proximodistal gradient of increasing intensity, beginnin

93 A proximodistal gradient of involvement of vasti muscles w

94 thin this distal portion of the subiculum, a proximodistal gradient of origin maps onto a presubicula

95 uencing (LM-RNAseq) was performed along this proximodistal gradient, and complementary network analys

96 Here we report the presence of striking proximodistal gradients in intrinsic membrane properties

97 Evidence is presented for proximodistal gradients of gene expression that establis

98 Four-jointed (fj) is required for proximodistal growth and planar polarity in Drosophila t

99 rowth and for the specification of points of proximodistal growth.

100 This proximodistal identity can be regulated by ectopic expre

101 RA can respecify proximodistal identity in amphibian limb regeneration, a

102 The molecular basis is not understood, but proximodistal identity in newt blastemal cells may be re

103 gress zone model, which states that a cell's proximodistal identity is determined by the length of ti

104 onstrate that the ability of RA to respecify proximodistal identity is mediated by a specific RAR iso

105 in Prod 1 is a critical determinant of their proximodistal identity.

106 r studies suggest that RA signaling provides proximodistal information for limb buds that counterbala

107 ric apicolateral complexes that straddle the proximodistal junctional region between adjacent cells.

108 ) is a pleiotropic maize mutant that affects proximodistal leaf development.

109 ptual model for spatiotemporal patterning of proximodistal leaf domains, and provides a rich resource

110 nd constructed spatiotemporal maps along the proximodistal length to quantify the frequency, velocity

111 ical ectodermal ridge (AER), is critical for proximodistal limb outgrowth mediated by FGFs.

112 ivate DLX genes, thereby contributing to the proximodistal limb patterning defects in CdLS.

113 that the fibroblast stem cells that regulate proximodistal limb patterning during regeneration are ta

114 Broadly, these results demonstrate that proximodistal morphology is regulated independently from

115 in differentiated muscle, implying that the proximodistal muscle pattern depends on BMP-mediated exp

116 MPCs as a prerequisite for establishing the proximodistal muscle pattern, a process that involves ex

117 ary myofibers developed, causing an aberrant proximodistal muscle pattern.

118 esrrgammaa deficiency altered proximodistal nephron patterning, decreased the multicil

119 asculature, as well as lines demarcating the proximodistal or abaxial/adaxial axes of the organs.

120 le involved in limb bud patterning along the proximodistal or anteroposterior axes functioning throug

121 t that RA signaling is not required for limb proximodistal or anteroposterior patterning but that RA

122 Thus, proximodistal organization of entorhinal inputs is instr

123 Our results add new details to the proximodistal organization of projections to the pre- an

124 found to couple dorsoventral patterning and proximodistal outgrowth during leaf development.

125 erning within the frontonasal prominence and proximodistal outgrowth of the middle and upper face.

126 ly anteroposterior (A-P) in the anterior and proximodistal (P-D) in the posterior.

127 However, signals that regulate proximodistal (P-D) patterning and thus formation of bet

128 including the lungs, which exhibit a defined proximodistal (P-D) polarity.

129 nd fly legs, suggesting that some aspects of proximodistal (P/D) patterning are evolutionarily conser

130 stal-less is required for the elaboration of proximodistal pattern elements in Drosophila limbs and c

131 in a dose-dependent fashion to organize the proximodistal pattern.

132 istal-less is genetically separable from the proximodistal patterning function in that certain Distal

133 We provide evidence that appendage proximodistal patterning genes are expressed in similar

134 he epistatic relationships among three major proximodistal patterning genes, Distal-less, dachshund a

135 segmentation by regional combinations of the proximodistal patterning genes.

136 Proximodistal patterning in Drosophila requires division

137 This similarity between proximodistal patterning in vertebrates and flies suppor

138 In vertebrates, however, proximodistal patterning is regulated by receptor tyrosi

139 Moreover, molecular evidence that proximodistal patterning is unaffected after X-irradiati

140 anar cell polarity (PCP), metabolism and the proximodistal patterning of appendages.

141 al discs, planar cell polarity (PCP) and the proximodistal patterning of appendages.

142 he Distal-less gene is known for its role in proximodistal patterning of Drosophila limbs.

143 h encodes a myb-domain protein that controls proximodistal patterning of leaves.

144 itional evidence that the Dlx genes regulate proximodistal patterning of the branchial arches.

145 at thyroid hormone (TH) regulates aspects of proximodistal patterning of the caudal fin rays, regardl

146 Individual paralog groups control proximodistal patterning of the limb skeletal elements.

147 Modulating proximodistal patterning relative to size-either through

148 lt in tissue overgrowth and abnormalities in proximodistal patterning that phenocopy deleting a speci

149 at the intracellular domain of Ds can affect proximodistal patterning, both suggestive of functions i

150 ically with ft and ds in planar polarity and proximodistal patterning.

151 digits, defects in both anteroposterior and proximodistal patterning.

152 lates growth, planar cell polarity (PCP) and proximodistal patterning.

153 re Fgf-signaling regulates cell survival and proximodistal patterning.

154 required for its activity in growth, PCP and proximodistal patterning.

155 mation depends on the subdivision of the leg proximodistal (PD) axis into broad domains by the leg ga

156 Limb growth along the proximodistal (PD) axis is controlled by the apical ecto

157 gradient of positional information along the proximodistal (PD) axis of the appendage that assigns re

158 s, for head development, and for forming the proximodistal (PD) axis of the appendages.

159 The proximodistal (PD) axis of the Drosophila leg is thought

160 p) organize positional information along the proximodistal (PD) axis of the Drosophila wing imaginal

161 ngation axis that gradually aligns along the proximodistal (PD) axis of the organ.

162 t limb bud, FGFR1 promotes the length of the proximodistal (PD) axis while restricting the dimensions

163 mb development requires the elaboration of a proximodistal (PD) axis, which forms orthogonally to pre

164 aplegic (Dpp) and Wingless (Wg), to form the proximodistal (PD) axis.

165 sential for limb pattern formation along the proximodistal (PD) axis.

166 orientation of cell divisions primarily in a proximodistal (PD) direction.(7)(,)(8) Here, we investig

167 ed with retinoic acid (RA), which results in proximodistal (PD) limb duplications.

168 Regenerating limbs retain their proximodistal (PD) positional identity following amputat

169 s within a limited recruitment zone to reset proximodistal (PD) positional information and assemble t

170 egulate limb patterning and growth along the proximodistal (PD), anteroposterior (AP) and dorsoventra

171 at orientations of growth are specified by a proximodistal polarity field, similar to that hypothesis

172 In combination with an orthogonal proximodistal polarity field, this system can generate d

173 formation of PIN1 convergence sites within a proximodistal polarity field.

174 vary in space and time and are oriented by a proximodistal polarity field.

175 al arches, embryonic structures that exhibit proximodistal polarity.

176 stema replaces structures appropriate to its proximodistal position.

177 thin developing vertebrate limbs occurs in a proximodistal progression.

178 he lateral plate mesoderm, which generates a proximodistal RA signal during limb outgrowth.

179 Cuttlefish also show proximodistal regionalization of Hth, Exd, Dll, Dac, Sp8

180 postcoitum; dpc) were subdivided into three proximodistal regions and transplanted into three sites

181 issue interactions differs between different proximodistal regions of the limb.

182 To identify which receptor(s) mediates proximodistal respecification, we have used the biolisti

183 f a cellular subpopulation that normally has proximodistal restrictions.

184 gest a model in which mecom and RA arbitrate proximodistal segment domains, while MCC fate is modulat

185 It has been recently proposed that distinct proximodistal segments are established early in limb dev

186 e specification and patterning of one of the proximodistal segments of the limb (upper arm, lower arm

187 laginous elements arranged in three distinct proximodistal segments resembling the developing stylopo

188 Facial retrusion, the proximodistal shortening of the snout and widening of th

189 long the two principal axes of the limb: the proximodistal (shoulder to finger) and anteroposterior (

190 meobox genes that are expressed in different proximodistal spatial domains corresponding to presumpti

191 g progenitors and provide novel insight into proximodistal specification during human lung developmen

192 thus implicating both signaling pathways in proximodistal specification in human lung development.

193 o propose that the acquisition of particular proximodistal subdomains and the evolution of their inte

194 This reveals that there are proximodistal substructures within the apical notch that

195 hibit antenna-to-leg transformations without proximodistal truncations.