ライフサイエンスコーパス: pseudopeptide

1 hes to the target phosphinic acid containing pseudopeptide.

2 ted derivatives of both diastereomers of the pseudopeptide.

3 lass of phosphorus compounds, thiophosphinyl pseudopeptides.

4 developed in order to access polyfunctional pseudopeptides.

5 ide replacements in some biologically active pseudopeptides.

6 the synthesis of N-(hydroxy)amide-containing pseudopeptides.

7 er, because the conformationally constrained pseudopeptide 10 was significantly more potent than its

8 This pseudopeptide, [6-Pha-Ala0]Lom-MT-II, was found to have

9 The pseudopeptides 7-9 were found to be competitive inhibito

10 this goal, the conformationally constrained pseudopeptides 8 and 10 and their corresponding flexible

11 Pseudopeptides 8 and 9 were found to be weak competitive

12 olution by the two cyclopropane rings in the pseudopeptides 9-12 appears to correspond closely to the

13 Pseudopeptides 9-12 were found to be competitive inhibit

14 Antimicrobial cyclic pseudopeptides (ACPPs) are based on the properties of an

15 es of the enzyme with bound transition-state pseudopeptide analogs at 1.68 angstrom and 1.72 angstrom

16 resin afforded 3,4-ketomethylene-stabilized pseudopeptide analogs of thymopentin.

17 A pseudopeptide analogue with high affinity for both HLA-B

18 JMV594 ([d-Phe(6),Stat(13)]Bn(6-14)), and a pseudopeptide analogue, JMV641 (d-Phe-Gln-Trp-Ala-Val-Gl

19 straints to reduce the flexibility of linear pseudopeptides and to help enforce the biologically acti

20 The pseudopeptide antibiotic andrimid is a nanomolar inhibit

21 However, en route to the target pseudopeptide, Arbuzov reaction of RP(OTMS)(2) with a cy

22 The assembly of beta-peptides, peptoids and pseudopeptides are also evaluated in this critical revie

23 Hence, these etpro-pseudopeptides are emerging peptidomimatics that form B-

24 e synthesis and structural analyses of novel pseudopeptides as ethylenediprolyl (etpro) tetra/hexapep

25 Conformational differences of the pseudopeptide backbones and the presence of disordered w

26 ich the cysteine is linked through a reduced pseudopeptide bond to 4-amino-3'-carboxybiphenyl.

27 glycine esters were converted to the desired pseudopeptides by Michael addition to alpha-methyleneglu

28 conformationally constrained, diastereomeric pseudopeptides CAbuPsi[COcpCO]FM 7-9, the flexible analo

29 ent studies have shown that oligopeptides or pseudopeptides can be synthesized by amide-bond-forming

30 Structural studies of the pseudopeptides carried out by NMR and circular dichroism

31 are mimics with normal bases connected to a pseudopeptide chain that obey Watson-Crick rules to form

32 yamide or N-(hydroxy)thioamide linkages into pseudopeptide chains without racemization.

33 g of the cytosol-open model could identify a pseudopeptide competitive inhibitor showing >100-fold hi

34 De novo cyclic pseudopeptides composed of alpha-amino and aza-beta(3)-a

35 conformational analysis of such beta-lactam pseudopeptides conducted in CDCl(3) and DMSO-d(6) soluti

36 ong-range chiral effects on the alpha-lactam pseudopeptide conformers were also found when two (i) an

37 A series of pseudopeptides containing alkyl-, cycloalkyl-, aryl-, an

38 The first three-dimensional structures of pseudopeptides containing aza-beta(3)-amino acids in aqu

39 N-Blocked pseudopeptides containing Val(k)Phe, Ala(k)Phe, and Val(

40 The bombesin-based pseudopeptide DOTA-4-amino-1-carboxymethylpiperidine-d-P

41 The pseudopeptides experience a significant degree of flexib

42 Further, the phosphinic pseudopeptide framework was exploited to generate an opt

43 In the repertoire of synthetic peptides, pseudopeptides have emerged as attractive small peptidom

44 ure of the substitution, this can render the pseudopeptides inactive or lead to a drastic enhancement

45 o induce conformational constraints in known pseudopeptide inhibitors of a number of important enzyme

46 or PfMetAP-II as well as to screen two novel pseudopeptide inhibitors of MetAPs.

47 eries of reversible tight-binding phosphinic pseudopeptide inhibitors that show high specificity and

48 This pseudopeptide is designed from our previously reported R

49 These findings show that amphiphilic pseudopeptide mimics of insect neuropeptides will penetr

50 Novel enantiopure pseudopeptide models containing a central -(beta-lactam)

51 Ester prodrugs of the phosphinate pseudopeptide N-[(4-deoxy-4-amino-10-methyl)pteroyl]glut

52 Our results show that the multivalent pseudopeptide N6L inhibited Matrigel invasion of MDA-MB-

53 his study analyzed the role of ketomethylene pseudopeptides of thymopentin as potential agents for th

54 merization of a alpha5beta1 integrin-binding pseudopeptide on the triazacyclononane-triphosphinate (T

55 ra and aid in the design of peptidomimetics, pseudopeptides or small molecules capable of disrupting

56 N-Prolinylanthranilamide-based pseudopeptide organocatalyst 14 was shown to promote ena

57 A synthetic pseudopeptide, [Phe(1)iota(CH(2)-NH)Gly(2)]-nociceptin(1

58 The phosphinic pseudopeptides presented here constitute the first examp

59 Although the pseudopeptide prodrugs were ineffective, prodrugs of met

60 ltransferase are described which are reduced pseudopeptides related to the C-terminal tetrapeptide of

61 eatment with fluoromethyl ketone-derivatized pseudopeptides rescued mice from lethal infection.

62 To achieve cure of infection, this pseudopeptide scaffold was incorporated in a less toxic

63 The optimal pseudopeptide scaffold was phenylalanine-homophenylalani

64 the synthesis of a library of thioacetylated pseudopeptides that were screened against human sirtuins

65 ctam 11 was converted into diastereoisomeric pseudopeptides to investigate its ability to induce seco

66 1 and ERAP2 to design and develop phosphinic pseudopeptide transition state analogs that can inhibit

67 ere detected in the absence or presence of a pseudopeptide trap.

68 This pseudopeptide was more stable in serum than 26RFa((20-26

69 A tris(carbobenzyloxy)arginyl(k)norleucine pseudopeptide was synthesized and coupled to Asp-Val-Phe

70 Conformational studies of these pseudopeptides were carried out in the solid state (X-ra

71 All of these pseudopeptides were less potent than the tetrapeptide pa

72 Studies of the SAR of these alkylated pseudopeptides with concomitant modification of the side