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1 2), which became known as the 'proton radius puzzle'.
2  surface, represents a fundamental, unsolved puzzle.
3 ly one Igalpha/Igbeta heterodimer has been a puzzle.
4 tive cell, is an ideal system to tackle this puzzle.
5  of the copper oxides ('cuprates') remains a puzzle.
6 biological activity of Ln(3+) presents a big puzzle.
7 ovides an important piece of the mechanistic puzzle.
8 eral intelligence poses a major evolutionary puzzle.
9 of life, but how has been a long-outstanding puzzle.
10 t disturbance, this remained a centuries-old puzzle.
11 ying accretion rates-has been a longstanding puzzle.
12 obesity, we propose one missing piece of the puzzle.
13  How to reconcile the results has reminded a puzzle.
14  density ns on the overdoped side is a major puzzle.
15  auditory processing has been a longstanding puzzle.
16  piece in the IL-1beta-mediated inflammation puzzle.
17 l piece of understanding to the evolving K2P puzzle.
18 ethnographically, represents an evolutionary puzzle.
19 gage diverse ligands remains a controversial puzzle.
20 for development and has been a morphogenetic puzzle.
21  SQUIDs and qubits is still a major unsolved puzzle.
22 roteins assemble yet another piece of the PD puzzle.
23 ative metal substitutions is a long-standing puzzle.
24 rning, pride provides a pivotal piece of the puzzle.
25 s a crucial piece of the human chronobiology puzzle.
26 nal spatial configurations while solving the puzzles.
27  72 players on a select set of more advanced puzzles.
28 f human aggression helps solve two important puzzles.
29 ents, we encountered a series of mechanistic puzzles.
30 e is involved in this activity have remained puzzling.
31 trategies typical of pathogens have remained puzzling.
32 ell release inside the female gametophyte is puzzling.
33 egulate YAP1's nuclear localization is still puzzling.
34 e ecologically ubiquitous but evolutionarily puzzling.
35 ul Metropolitan Area (SMA), South Korea, are puzzling.
36  Earthquake faulting at 600 km depth remains puzzling.
37 e the direction of illumination has remained puzzling.
38 ral lifespan is a long-standing evolutionary puzzle [1-4].
39  of complex societies represent evolutionary puzzles(1-8).
40 g(1,2), but how it occurs in cities is often puzzling(3).
41 ed actinide material, remain a long standing puzzle, a result of strong coupling between magnetism an
42 hods during the succeeding challenges of RNA-Puzzles, a community-wide effort on the assessment of bl
43 riments which however revealed an intriguing puzzle: a polarization difference between particles and
44 ing hormone (GnRH) represents a longstanding puzzle about extracellular signal decoding mechanisms.
45                                This solves a puzzle about why genes associated with human disease are
46  allowed us to resolve several long-standing puzzles about the atomistic OER mechanism.
47 dden state framework can resolve a number of puzzles about the nature of remapping.
48    Whilst the scientific community was still puzzling about the cause of the aborted EN event in 2014
49            A new study helps to explain this puzzling activation using a novel activator, thorough ki
50 etween selective pressures in other cases of puzzling adaptive polymorphism.
51 e very uniqueness of human culture is both a puzzle and a problem.
52 screening strategy solves this long-standing puzzle and identifies NACHO, a transmembrane protein of
53              Our work solves a long-standing puzzle and provides a quantitative framework for the car
54           We propose a simple answer to this puzzle and show that although at low densities, nucleoso
55     In this Opinion article, we address this puzzle and the related question of why pathogens often h
56 e also highlight open questions, theoretical puzzles and problems shared with computer science and in
57 ur results provide insights into a number of puzzling and contradictory motor adaptation data, as wel
58 ause of death worldwide and perhaps the most puzzling and devastating of all human behaviors.
59  a knotted structure remains one of the most puzzling and fascinating features of protein folding.
60 lar mechanism by which CD5 operates has been puzzling and its function in mature T cells suggests pro
61 ms of archaeal DNA transport have remained a puzzling and underinvestigated topic.
62  0.035) in the affect recognition, geometric puzzle, and block construction scores, respectively.Vita
63 ted explanations for known experimental FRET puzzles, and it provides theoretical foundations for opt
64 rnal-age-at-conception (PAC) effect on TL is puzzling, and its biological implication at the populati
65 ronze Age Minoan and Mycenaean cultures have puzzled archaeologists for more than a century.
66           The assessment metrics used in RNA-Puzzles are briefly described.
67              This explains the long-standing puzzle as to why the neutralization of the intracellular
68 ng mammals, ungulates, pose two evolutionary puzzles as helminth hosts.
69 player moves on 12 of the most-played Eterna puzzles as well as an eternamoves-select repository of 3
70                                        It is puzzling as to why more species have not adopted this ma
71 neural responses in primary sensory areas is puzzling, as it is detrimental to the exact mapping betw
72 coordination structure of Ni, remains highly puzzling, as previous density functional theory (DFT) ca
73        The natural origin of this ability is puzzling, as the species is not reported to use trunk- o
74 w of this kind can help to explain otherwise puzzling aspects of biology, including the complexity an
75                              One of the most puzzling aspects of the prion diseases is the intricate
76 ns under specific conditions, and to resolve puzzles associated with their deviations in terms of con
77 l data include spherical vesicles and jigsaw-puzzle association of broken crystals in pumices, wherea
78 main evolutionary narratives for this rather puzzling association.
79                          This, in fact, is a puzzle because a molecular switching mechanism should id
80                             Coexistence is a puzzle because we lack a mechanistic understanding of th
81 ng these distinctive transport mechanisms is puzzling because CLC channels and transporters are expec
82        Paternal provisioning among humans is puzzling because it is rare among primates and absent in
83                         This is all the more puzzling because neutron scattering suggests that the an
84                                     This was puzzling because S is thought to somehow correlate with
85 s in behavioral and neural effects have been puzzling because the compounds target distinct molecular
86                                      This is puzzling because the tissue at the anatomically defined
87 ecular signals triggering cell division is a puzzle, because any molecule inducing and aiding growth
88 ng is a clinical concern, but its causes are puzzling, because alcohol (ethanol) is a calorie-dense n
89 of this cold, dense and high-velocity gas is puzzling, because neither Sagittarius A* at its current
90 cal basis for smaller lesions, they remained puzzling; because K1 antagonizes NF-kappaB in vitro, ant
91 w that the resulting model accounts well for puzzling behavioral data on human participants and makes
92        Our findings explain three previously puzzling behaviors seen in brown dwarf brightness variat
93  Our results thus help to explain a range of puzzling behaviors, such as extreme altruism, the use of
94     Most animals sleep regularly, which is a puzzling behaviour, considering the risk of predation th
95  solve difficult but not simple tasks in the puzzle box assay and impaired memory in the novel object
96 em-solving abilities were assessed using the puzzle box assay, and memory performance was studied wit
97  traditions for opening a bidirectional door puzzle box in replicate subpopulations of the great tit
98 test, a social preference T-maze test, and a puzzle box test.
99 rved to influence pig's ability to solve the puzzle box.
100 t only offer a surprising solution to an old puzzle but demonstrate that even complex brains can trus
101 al communicates across its network remains a puzzle, but Physarum polycephalum has emerged as a novel
102        Herein, we resolved this longstanding puzzle by combining a detailed product analysis, with re
103 In this work, we finally complete the jigsaw puzzle by reporting the isolation of the first low valen
104 ponential-type loss functions, we solve this puzzle by showing an effective regularization effect of
105  cell patterns in 1665, scientists have been puzzled by why cells form such ordered structures.
106 g gods' hypothesis offers a solution to both puzzles by proposing that belief in morally concerned su
107                  As a test, on two blind RNA-Puzzles challenges, EvoClustRNA predictions ranked as th
108 n RCTs evaluating treatment of HABP/VABP may puzzle clinicians.
109 alanaerobiales and the Negativicutes shows a puzzling combination of monoderm and diderm features.
110 ds and considerations exhibits the otherwise puzzling combination of objective and subjective element
111                             As pieces of the puzzle come together, from yeast and Drosophila fly tran
112                      Our results may solve a puzzling conflict between eco-evolutionary theory that p
113                                      The RNA-Puzzles contest has shown, among others, that the develo
114 peroxide (FeO(2)Hx with x = 0 to 1), but the puzzling crystal chemistry of this system at high pressu
115 chers have often observed an unpredicted and puzzling decrease with repeated assessment.
116 orque and rotational motion presents a major puzzle despite significant biophysical and structural pr
117 lls during angiogenesis is an intriguing but puzzling developmental process.
118 f canonical Cu(A) sites, there are also some puzzling differences.
119    Our study provides an explanation for the puzzling dissimilarity of ARF6 to other ARFs and suggest
120 n the BRaliBase benchmark, one can observe a puzzling drop in accuracy in the 40-60% sequence identit
121                             To explore these puzzling effects and their mechanisms further, we repeat
122 el recapitulating all aspects of the GBA1-PD puzzle, emphasizing the importance of selecting the prop
123 tructure-function relationships in uPAR, one puzzling enigma remains unexplored.
124 on transmission and a framework to reconcile puzzling epidemiological features of certain prion disor
125 ng to their geometrical complexity are still puzzling, especially for nonuniformly sized components.
126 o three dimensions during outgrowth is still puzzling, especially when cells are tightly connected as
127 re (PSAP)] that required rats to solve a new puzzle every day to gain access to cocaine, which they t
128 iers to gene flow (sympatric speciation)-has puzzled evolutionary biologists ever since Darwin(1,2).
129 e has evolved in females of some species has puzzled evolutionary biologists for over 50 years.
130     Our results provide explanations for the puzzling fact that growth of B. subtilis does not result
131                              A pervasive yet puzzling feature of cortical circuits is that despite th
132 ustaining extracellular matrix (D-ECM), is a puzzling feature of pancreatic ductal adenocarcinoma (PD
133 cellular prion protein of the host, PrP(C) A puzzling feature of prion formation is that certain PrP(
134 characteristics of the event and constraints puzzling features inferred from high-quality observation
135              One of the fossil record's most puzzling features is the absence of preserved eggs or eg
136          One of their most controversial and puzzling features is their distinctive caudal anatomy, w
137  lens of efficiency in usage: what otherwise puzzling features of language find explanation in formal
138                              One of the most puzzling features of the prehistoric record of hominid s
139                     This study addresses the puzzling finding that the direct entorhinal cortical inp
140                                             "Puzzle-fit" analysis was used to correlate the fluoresce
141   Our work not only explains a long-standing puzzle for an important catalyst but also highlights the
142            Progress towards unravelling this puzzle for Earth is hindered by the scarcity of well-pre
143 of our moral cognition represents a profound puzzle for evolutionary approaches to human moral psycho
144                                            A puzzle for neuroscience-and robotics-is how insects achi
145                             We approach this puzzle from a reinforcement learning perspective: what k
146 lly isolated and others are not is therefore puzzling from an evolutionary perspective.
147 erceptual attention skills and using spatial puzzle games to train two-dimensional mental rotation sk
148                   This mechanism illuminates puzzling gene expression data and suggests novel enginee
149  variability on a congenic B6 background has puzzled geneticists for decades.
150                                Although this puzzling genome architecture is found in ~17% of known v
151                             Yet, it has long puzzled geochemists why the laboratory synthesis of todo
152 he clinical manifestations of some otherwise puzzling GGCX gene mutations in humans that cause phenot
153                              A long-standing puzzle has been why the AU dincucleotide at the 5'-end o
154  major questions still remaining?" as if the puzzle has only a few pieces missing.
155                                 Particularly puzzling has been the apparent lack of cooperativity in
156                                To solve this puzzle, here we constructed a dataset including Ys from
157 e detrimental and beneficial effects remains puzzling. Here, to understand how cells develop toleranc
158                                 It remains a puzzle how or whether this multitude of arrangements in
159                          However, it remains puzzling how host immunity selects for antigenic diversi
160                              It has remained puzzling how so few pathways can provide the precision a
161  nonspecifically degraded RNA in vitro It is puzzling how such nonspecific endonuclease activity gene
162 d or impaired learning, raising a conceptual puzzle: how enhanced plasticity can yield opposite learn
163    Multifunctional proteins are evolutionary puzzles: how do proteins evolve to satisfy multiple func
164               In the light of this empirical puzzle, I argue that Van Lange et al.'s CLASH model woul
165  long appreciated, this duality continues to puzzle immunologists and has implications for the develo
166                                One recurring puzzle in both intra- and inter-species studies is the h
167 re T down to low T have been a long-standing puzzle in condensed matter physics.
168 rigin of eukaryotes represents an unresolved puzzle in evolutionary biology.
169 ar importer of PAP, providing a piece of the puzzle in our understanding of the organelle-to-nucleus
170 vides a possible solution to a long-standing puzzle in the field about the versatility of LiNO(3) sal
171 the cuprates is arguably the most mysterious puzzle in the field of high-temperature superconductivit
172  can be predicted, resolving a long-standing puzzle in the literature.
173  provides a unified account of long-standing puzzles in 3D vision at the physiological and perceptual
174 itable regions is one of the most intriguing puzzles in archaeological research, with implications fo
175  solve a large range of challenging physical puzzles in just a handful of attempts.
176 nt molecular-level insights on long-standing puzzles in nanochemistry, including LaMer growth, aggreg
177 ar atmosphere is one of the most fascinating puzzles in plasma-astrophysics.
178 man players solves 61 out of 100 independent puzzles in the Eterna100 benchmark.
179                     Two of the long-standing puzzles in the field are the nature of active sites for
180  of study, it remains one of the fundamental puzzles in the field of crystal growth.
181            These results resolve some of the puzzles in the literature and indicate that the AnG can
182 on and compass-navigation is fascinating and puzzling in equal measure.
183                          We describe the RNA-Puzzles initiative, which is a community-wide, blind ass
184     An important missing piece of the Ln(3+) puzzle is defining what features distinguish enzymes tha
185 rbed climate simulations, we argue that this puzzle is explained by weaker atmospheric circulation in
186                                          The puzzle is that the propensity for aggressive behavior wa
187                                   The bigger puzzle is their lower frequency among the affluent.
188                           This long-standing puzzle is usually explained by charge inhomogeneity.
189 n state structures of enzymes, an intriguing puzzle is whether an enzyme can accommodate multiple tra
190                                      Equally puzzling is how quickly these systems can be activated a
191                      For example, one of the puzzling issues which have attracted significant interes
192                                 We show that puzzling magnetization increase with decreasing magnetic
193 ions of proteins and other molecules exhibit puzzling, mesoscopically sized inclusions of a solute-ri
194 any mammalian organ, a finding that has long puzzled molecular biologists.
195                        We also reproduce the puzzling N-H stretching band of porphycene with very goo
196 vital role in solving the strong-correlation puzzle, namely, revealing the physics of a large number
197         Here we offer an explanation of this puzzling observation based on the structure of contact n
198                                         This puzzling observation is attributed to a two-stage proces
199                                          One puzzling observation is that, after stroke, upper limb f
200 eld provides a nontrivial explanation to the puzzling observation of a difference in spin hydrodynami
201  mutans regulates bimodality and explain the puzzle of growth medium effects on competence induction
202 ntary choices, these opportunities raise the puzzle of how people attain the common knowledge that fa
203                                A fundamental puzzle of human evolution is how we evolved to cooperate
204                                            A puzzle of language is how speakers come to use the same
205 ing modules (CBMs), resulting in a molecular puzzle of mechanisms governing substrate preference and
206       Other than resolving the long-standing puzzle of observed compressive fluctuations in the solar
207 s, resolving, along the way, a long-standing puzzle of the experimentally observed finite thermoelect
208                             The evolutionary puzzle of the extended post-reproductive life of female
209 d, Calzavarini et al solve the long-standing puzzle of the function of protein S (PS) that has been d
210  Archimedes was believed to have solved "The Puzzle of The King's Crown" using density.([1]) Today, m
211  Archimedes was believed to have solved "The Puzzle of The King's Crown".
212 as pivotal to the evolution of life, but the puzzle of when and how atmospheric oxygen (O2) first app
213 sland of Madagascar remains one of the great puzzles of Indo-Pacific prehistory.
214 characterized by recognizing the fascinating puzzles of virus diseases, being in good places at the r
215                     Our finding resolves the puzzle on why the single-atom silver dispersion can be s
216  a system which appears to solve jigsaw-like puzzles on its way to organizing into a large-scale disc
217 Yaravirus, a lineage of amoebal virus with a puzzling origin and evolution.
218 cient supercontinent Gondwana - except for a puzzling outpost in southeast Asia.
219 or decades scientists in the field have been puzzled over the differences in mechanisms between class
220 The Spanish artist Diego Velazquez created a puzzle-painting 360 years ago that to this day remains u
221                                      It is a puzzling paradox that fossils of benthic animals are oft
222 ed geographically localized for so long is a puzzle, particularly in light of the rapidity of its sub
223 omains, all of which helps to understand the puzzling pharmacology and pathophysiology of this channe
224           This mechanism explains previously puzzling phenomena, including the adaptation of the peri
225 ative behavior, a natural, pervasive and yet puzzling phenomenon, can be significantly enhanced by ne
226 of glomus cells in the carotid body has long puzzled physiologists.
227               Leaf epidermis contains jigsaw puzzle piece-shaped pavement cells whose shape has been
228 cts with assembly properties (fanciful ball, puzzle pieces, 3D pixels, propellers, fluidic and multic
229                    The origin of flowers has puzzled plant biologists ever since Darwin referred to t
230  and steady decline of chimpanzees represent puzzling population paradoxes, as any species must exhib
231 s have revived the interest in unveiling the puzzling processes of melting transitions.
232                           We show that these puzzling properties arise from a duality between pairs o
233               Among the most distinctive and puzzling properties of these compounds is their ability
234 n which multidomain proteins fold has been a puzzling question for decades.
235 ears to be one important explanation for the puzzling question of why addicted individuals continue d
236 the host and the microbiota may help resolve puzzling questions such as how a microorganism can contr
237                               This generates puzzles regarding the phenomenology of temporal experien
238 any key issues, apparent contradictions, and puzzles remain to be solved.
239 arify how phytochromes respond to light, but puzzles remain.
240 te experimental and theoretical efforts, the puzzle remains unresolved.
241                              A long-standing puzzle remains unsolved: why the Au surfaces with {100}
242                                   Hence, the puzzle remains: how a single-amino-acid difference betwe
243                      This explains both, the puzzling requirement of Egfr in oncogenic Ras-mediated o
244 ure is recalled by appendage stump cells has puzzled researchers for centuries.
245  its wavelength-dependent photochemistry has puzzled researchers for decades.
246                                        These puzzling results prompted us to ask whether neuroligin-3
247 here they host hotspots of extraordinary and puzzling richness.
248 ately reject, a candidate resolution for the puzzling RPE vs movement dichotomy, by showing how seemi
249 oases of life in low-productivity oceans has puzzled scientists for centuries.
250 lobal terrestrial sink of carbon dioxide has puzzled scientists for decades.
251 unction of pocket shark pectoral pockets has puzzled scientists over decades.
252 novel cocaine self-administration procedure [puzzle self-administration procedure (PSAP)] that requir
253 lant species, PCs form highly complex jigsaw-puzzle-shaped cells with interlocking lobes.
254                                   The jigsaw puzzle-shaped pavement cells in the leaf epidermis colle
255                                              Puzzle-shaped pavement cells provide a powerful model sy
256                                This has been puzzling since fixing nitrogen is energetically ineffici
257 on-inducible M cells, provides an intriguing puzzle: some variants may augment luminal surveillance t
258   Moreover, this mechanism can explain other puzzling spatiotemporal features of drug-resistance epid
259 phic protocols, games like sudoku, crossword puzzles, speed chess, and so on.
260                                          The puzzle still requires multiple additional pieces for com
261 he NEPSY II affect recognition and geometric puzzle subtests.
262 ics and transcriptomics has further resolved puzzles such as the exact position of myriapods or the c
263                      Essential clues to this puzzle, such as the symmetry and spatial distribution of
264 ction may help to resolve various scientific puzzles, such as: (i) opposing views on the different fu
265 n rate estimates for baboons raise a further puzzle, suggesting a divergence time between apes and Ol
266 iron and could be integral to explaining its puzzling superconductivity.
267                        There was also Rap1's puzzling suppression of Raf-1 versus activation of BRAF.
268 built from heterodimers and utilise a jigsaw-puzzle system of pegs and holes, and underlying minor ca
269      Sexual signal design is an evolutionary puzzle that has been partially solved by the hypothesis
270 ation, scientists get their kicks by solving puzzles that advance biomedical research.
271 n to human video game players in the form of puzzles that reach extraordinary difficulty.
272 ke artists who get their thrills by creating puzzles that stimulate the imagination, scientists get t
273           Finally, I present some additional puzzles that will require further theoretical and experi
274 spacers should confer a better memory, it is puzzling that so little genetic space would be devoted b
275 fference in sign of volume changes have been puzzling the field for the past 50 years.
276 rials with unusual properties that have been puzzling the scientific community since their discovery.
277                 Yet, a key component of this puzzle-the contributions of individual species to the ov
278     X inactivation presents two longstanding puzzles: the counting and choice of X chromosomes.
279 mosomes of great apes represent a particular puzzle: their gene content is more similar between human
280                                          The puzzle then is the following: how does a cohesin molecul
281                         To understand such a puzzling thermal transport behavior, we have thoroughly
282 ernal and internal sounds, and several other puzzling tinnitus phenomena such as discrepancy in loudn
283  chagosensine-like compounds would allow the puzzle to be solved.
284                  It has been an old unsolved puzzle to evolutionary theorists on which mechanisms wou
285 catalysts coevolved remains a mystery in the puzzle to understand the origin of life.
286 is a decades-long taxonomic and phylogenetic puzzle to which cytogenetics has contributed crucial dat
287  in rats by requiring animals to solve daily puzzles to gain access to cocaine.
288                         Here, we present RNA-Puzzles toolkit, a computational resource including (i)
289 sp90's ATPase function, which has remained a puzzle up to now.
290    Ochsner et al. add several pieces to this puzzle, utilizing a model phyllosphere colonizer Methylo
291                 In the midst of this genomic puzzle, viruses, especially those that infect microbial
292 er, searching a medical image diverges, in a puzzling way, from the typical search for a target featu
293                              To unravel this puzzle, we employed a poly(A) tag sequencing protocol an
294                 Hamilton helped to solve the puzzle when he showed that cooperation can evolve if coo
295 s are fascinating, but often, they are quite puzzling, when the substrate is clearly not an epitaxial
296 eral intelligence poses a major evolutionary puzzle, which has led to increased interest in its prese
297  misunderstandings at the root of the cancer puzzle while providing a plausible and comprehensive bio
298 her" scroll fragments is like solving jigsaw puzzles with an unknown number of missing parts.
299 tructure and function is one of the greatest puzzles within biochemistry.
300          The hidden nature of causality is a puzzling, yet critical notion for effective decision-mak

 
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