ライフサイエンスコーパス: pyridoxal 5'-phosphate

1 tion by covalent modification of lysine with pyridoxal 5-phosphate.

2 ached but appears to be partially present as pyridoxal 5'-phosphate.

3 hieved by the simultaneous administration of pyridoxal 5'-phosphate.

4 shown to exist as a tetramer and to contain pyridoxal 5'-phosphate.

5 all organisms, notably as the coenzyme form pyridoxal 5'-phosphate.

6 ity of seizures in response to pyridoxine or pyridoxal 5'-phosphate.

7 h pyridoxine but responded to treatment with pyridoxal 5'-phosphate.

8 g of symptoms on changing from pyridoxine to pyridoxal 5'-phosphate.

9 etion and the blockade of these responses by pyridoxal 5-phosphate 6-azophenyl-2',4'-disulphonic acid

10 t to their ligand preference, sensitivity to pyridoxal 5-phosphate 6-azophenyl-2',4'-disulphonic acid

11 ovel analogues of the P2 receptor antagonist pyridoxal-5'-phosphate 6-azophenyl-2',5'-disulfonate (2)

12 e-6-azophenyl-2',5'-disulfonic acid (PPADS), pyridoxal-5'-phosphate-6(2'-naphthylazo-6-nitro-4',8'-di

13 Pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8'-

14 on of P2 and glutamate receptor antagonists (pyridoxal-5'-phosphate-6-azophenyl-2',4'-disulphonic aci

15 Application of the ATP receptor antagonists pyridoxal-5'-phosphate-6-azophenyl-2',4'-disulphonic aci

16 LM (microinjection of P2 receptor antagonist pyridoxal-5'-phosphate-6-azophenyl-2',4'-disulphonic aci

17 ntly inhibited by the purinergic antagonists pyridoxal-5'-phosphate-6-azophenyl-2',5'-disulfonic acid

18 The currents were inhibited by suramin, pyridoxal-5-phosphate-6-azo-2',4'-disulfonic acid and Br

19 mutation that prevented covalent binding of pyridoxal 5'-phosphate abolished the ability of DdlR to

20 and function of SHMT and a possible role in pyridoxal 5'-phosphate addition to the apo-enzyme.

21 bT promoter only in the presence of GABA and pyridoxal 5'-phosphate, an essential cofactor of aminotr

22 nase that is involved in the biosynthesis of pyridoxal-5-phosphate, an active form of vitamin B6.

23 at the minor allele is destabilized and that pyridoxal 5'-phosphate and aminooxyacetic acid binding s

24 We also examine the effect of known ligands pyridoxal 5'-phosphate and aminooxyacetic acid on stabil

25 regulated by modulation of the synthesis of pyridoxal 5'-phosphate and failure to maintain pyridoxal

26 A similar requirement for pyridoxal 5'-phosphate and GABA for GabR-mediated transc

27 involved in binding flavin mononucleotide or pyridoxal 5'-phosphate and many of them showed residual

28 alyzes a hydride ion transfer between C4' of pyridoxal 5'-phosphate and N5 of FMN.

29 n a novel metabolic pathway for synthesis of pyridoxal 5'-phosphate and the existing metabolic networ

30 The dependence of the enzyme on pyridoxal 5'-phosphate and the production of 3H4P with t

31 by pharmacological studies in animal cells, pyridoxal-5-phosphate and its derivatives are also ligan

32 mosine, pyridoxine, pyridoxamine, pyridoxal, pyridoxal-5'-phosphate) and various synthetic hydroxypyr

33 n the biosynthesis of the essential coenzyme pyridoxal 5"-phosphate, and the ksgA gene, which encodes

34 tanx is a product containing L-methylfolate, pyridoxal 5'-phosphate, and methylcobalamin for manageme

35 nine with the help of three cofactors, heme, pyridoxal-5'-phosphate, and S-adenosyl-l-methionine.

36 free to rotate and bring adenosylcobalamin, pyridoxal-5'-phosphate, and substrate into proximity.

37 enzyme functions as a homodimer and requires pyridoxal 5'-phosphate as a cofactor.

38 smitter gamma-aminobutyric acid (GABA) using pyridoxal 5'-phosphate as a cofactor.

39 for HMP-P biosynthesis as well as the use of pyridoxal 5'-phosphate as a substrate rather than as a c

40 MP) form of BCATm (PMP-BCATm) but not to the pyridoxal 5'-phosphate-BCATm and other metabolon protein

41 e that is also predicted to be important for pyridoxal 5'-phosphate binding to Lcb2p also dominantly

42 In this mode of pyridoxal-5'-phosphate binding, the cofactor acts as an

43 The enzyme is composed of a pyridoxal 5'-phosphate-binding catalytic domain, flanked

44 n the C-terminal domain, catalytic loop, and pyridoxal 5'-phosphate-binding domain that drives struct

45 pe proteins that have aminotransferase-like, pyridoxal 5'-phosphate-binding domains.

46 The enzyme activity requires pyridoxal 5'-phosphate but not alpha-keto acid; therefor

47 Other B6 vitamers are converted to pyridoxal 5'-phosphate by a preincubation with a combina

48 zes the terminal step in the biosynthesis of pyridoxal 5'-phosphate by the FMN oxidation of pyridoxin

49 tructure, a Rossmann domain covalently binds pyridoxal-5'-phosphate by means of lysine 144 and positi

50 Cysteine lyase contains haem and pyridoxal 5'-phosphate co-factors and converts cysteine

51 of covalent intermediates formed between the pyridoxal 5'-phosphate coenzyme (PLP) and the reacting s

52 The enzyme contains a pyridoxal 5' phosphate cofactor and is a dimer.

53 into a structure amenable to binding of the pyridoxal 5'-phosphate cofactor and assembly of the two

54 formed substrate channel and solvent-exposed pyridoxal 5'-phosphate cofactor and provides a rationale

55 termediates by masking the absorption of the pyridoxal 5'-phosphate cofactor.

56 expected to form the Schiff's base with the pyridoxal 5'-phosphate cofactor.

57 plays a role in modulating the pK(a) of the pyridoxal 5'-phosphate complexes during catalysis.

58 of NADPH production with respect to original pyridoxal 5'-phosphate content.

59 Ornithine decarboxylase (ODC) is a pyridoxal 5'-phosphate dependent enzyme that catalyzes t

60 nobutyric acid aminotransferase (GABA-AT), a pyridoxal 5'-phosphate dependent enzyme, catalyzes the d

61 Homo sapiens kynureninase is a pyridoxal-5'-phosphate dependent enzyme that catalyzes t

62 two genes, At2g20340 and At4g28680, encoding pyridoxal 5'-phosphate-dependent AADCs with high homolog

63 motetrameric enzyme that belongs to group II pyridoxal 5'-phosphate-dependent amino-acid decarboxylas

64 primary sequence analysis, MppP and MppQ are pyridoxal 5'-phosphate-dependent aminotransferases; MppR

65 Escherichia coli adiA gene, which encodes a pyridoxal 5'-phosphate-dependent arginine decarboxylase,

66 5-Aminolevulinate synthase catalyzes the pyridoxal 5'-phosphate-dependent condensation of glycine

67 a tetrameric hemeprotein that catalyzes the pyridoxal 5'-phosphate-dependent condensation of serine

68 heme biosynthesis in mammals begins with the pyridoxal 5'-phosphate-dependent condensation reaction c

69 In the ISC pathway, the pyridoxal 5'-phosphate-dependent cysteine desulfurase en

70 These are the pyridoxal 5'-phosphate-dependent deaminases and the deam

71 is an obligate homodimer that catalyzes the pyridoxal 5'-phosphate-dependent decarboxylation of l-or

72 mammals is controlled by the activity of the pyridoxal 5'-phosphate-dependent enzyme 5-aminolevulinat

73 allowing the elucidation of a key species of pyridoxal 5'-phosphate-dependent enzyme catalysis.

74 SelA, a member of the fold-type-I pyridoxal 5'-phosphate-dependent enzyme superfamily, has

75 Kynureninase is a pyridoxal 5'-phosphate-dependent enzyme that catalyzes t

76 O-Acetylserine sulfhydrylase is a pyridoxal 5'-phosphate-dependent enzyme that catalyzes t

77 SHMT is a pyridoxal 5'-phosphate-dependent enzyme that converts l-

78 5-Aminolevulinate synthase (ALAS), a pyridoxal 5'-phosphate-dependent enzyme, catalyzes the f

79 ition of ornithine aminotransferase (OAT), a pyridoxal 5'-phosphate-dependent enzyme, has been implic

80 Human ornithine aminotransferase (hOAT), a pyridoxal 5'-phosphate-dependent enzyme, plays a critica

81 Here, by comparing the inventory of pyridoxal 5'-phosphate-dependent enzymes in different am

82 duced expression of several glucagon-induced pyridoxal 5'-phosphate-dependent enzymes that convert am

83 s structural features with other fold-type-I pyridoxal 5'-phosphate-dependent enzymes with native dim

84 ctive enamine intermediate generated by some pyridoxal 5'-phosphate-dependent enzymes, accumulates in

85 t mutational routes between the functions of pyridoxal 5'-phosphate-dependent enzymes, regardless of

86 mix between periplasmic binding proteins and pyridoxal 5'-phosphate-dependent enzymes.

87 assay based on ethanolamine (Etn) formation, pyridoxal 5'-phosphate-dependent l-serine decarboxylase

88 th (13)C-labeled precursors indicated that a pyridoxal 5'-phosphate-dependent mechanism is involved i

89 any other euryarchaeon have orthologs of the pyridoxal 5'-phosphate-dependent ornithine or arginine d

90 reactive enamine/imine intermediates of the pyridoxal 5'-phosphate-dependent threonine dehydratase (

91 The enzyme is pyridoxal 5'-phosphate-dependent, but unlike most of the

92 aldehyde-lyase (threonine aldolase, TA) is a pyridoxal-5'-phosphate-dependent (PLP) enzyme that catal

93 roton-consuming acid resistance system has a pyridoxal-5'-phosphate-dependent amino acid decarboxylas

94 ystathionine beta-synthase (CBS) is a unique pyridoxal-5'-phosphate-dependent enzyme in which heme is

95 5,6-aminomutase is an adenosylcobalamin and pyridoxal-5'-phosphate-dependent enzyme that catalyzes a

96 Cystathionine beta-synthase (CBS) is a pyridoxal-5'-phosphate-dependent enzyme that catalyzes t

97 f the indoline quinonoid intermediate in the pyridoxal-5'-phosphate-dependent enzyme tryptophan synth

98 In the 143 kDa pyridoxal-5'-phosphate-dependent enzyme tryptophan synth

99 It is endogenously synthesized mainly by two pyridoxal-5'-phosphate-dependent enzymes involved in L-c

100 beta-synthase (CBS) is a heme-dependent and pyridoxal-5'-phosphate-dependent protein that controls t

101 f enzyme characterization revealed that this pyridoxal-5-phosphate-dependent decarboxylase takes L-ly

102 It is the only known pyridoxal-5-phosphate-dependent decarboxylase that catal

103 In contrast to the enzymes that employ pyridoxal 5'-phosphate, detailed physical and mechanisti

104 NSALP substrates inorganic pyrophosphate and pyridoxal 5'-phosphate diminished.

105 of the serine/threonine-specific protein and pyridoxal 5'-phosphate-directed HAD phosphatase chronoph

106 beta-synthase (CBS), a novel heme-containing pyridoxal 5'-phosphate enzyme, catalyzes the condensatio

107 As a soluble, pyridoxal 5'-phosphate enzyme, SDC contrasts sharply wit

108 This is the first instance in which one pyridoxal 5-phosphate enzyme has been crystallized with

109 As a member of the subfamily of pyridoxal 5'-phosphate enzymes known as the alpha-oxoami

110 the newly discovered enzyme does not require pyridoxal 5'-phosphate for its activity.

111 tunnel exists between the two sites so that pyridoxal 5'-phosphate formed at the active site may tra

112 e formation of the Michaelis complex and the pyridoxal 5'-phosphate-glycine aldimine, followed by the

113 Although pyridoxal 5'-phosphate hydrolase activity is usually att

114 c alkaline phosphatase may perform cutaneous pyridoxal 5'-phosphate hydrolase activity.

115 an skin, both of which exhibited significant pyridoxal 5'-phosphate hydrolase activity.

116 ith kinase and oxidase activity and not with pyridoxal 5'-phosphate hydrolase activity.

117 Pyridoxal 5'-phosphate hydrolase has been proposed as a

118 f both pyridoxamine 5'-phosphate oxidase and pyridoxal 5'-phosphate hydrolase was significantly incre

119 n the beta-site, indole and l-Ser react with pyridoxal 5'-phosphate in a two-stage reaction to give l

120 own genes involved in the salvage pathway of pyridoxal 5'-phosphate in plants.

121 Both substrates form external aldemines with pyridoxal 5-phosphate in the structures.

122 notransferase-like reaction between GABA and pyridoxal 5'-phosphate is essential for GabR action as a

123 In this method pyridoxal 5'-phosphate is used to activate aposerine hyd

124 Vitamin B(6) (pyridoxal 5'-phosphate) is an essential cofactor of many

125 s PNPO variant had a low cerebrospinal fluid pyridoxal-5-phosphate level.

126 adjusted for plasma folate, vitamin B12, and pyridoxal 5'-phosphate levels, age, and gender confirmed

127 yjgF mutants, suggests that intermediates of pyridoxal 5'-phosphate-mediated reactions may have metab

128 One of the pyridoxal 5'-phosphate molecules is clearly bound at the

129 antile spasms (onset 5 months) responsive to pyridoxal 5'-phosphate (n = 1); and (iii) patients with

130 s with neonatal onset seizures responding to pyridoxal 5'-phosphate (n = 6); (ii) a patient with infa

131 the active site with the aldehyde at C4' of pyridoxal 5'-phosphate near N5 of the bound FMN.

132 own homologs of the previously characterized pyridoxal 5'-phosphate or pyruvoyl-dependent arginine de

133 P < 0.05) and lower plasma vitamin B-12 and pyridoxal 5-phosphate (P < 0.05) than did nonsmokers.

134 and those with lower plasma concentration of pyridoxal-5'-phosphate (P-interaction <= 0.01 for both).

135 Enzymes that utilize the cofactor pyridoxal 5'-phosphate play essential roles in amino aci

136 s developed for the routine determination of pyridoxal 5'-phosphate (PLP) and 4-pyridoxic acid (4-PA)

137 sample preparation procedure for quantifying pyridoxal 5'-phosphate (PLP) and 4-pyridoxic acid (4PA)

138 The enzyme contains pyridoxal 5'-phosphate (PLP) and a [4Fe-4S] center and r

139 In the case of the pyridoxal 5'-phosphate (PLP) and cobalamin-dependent enz

140 aeruginosa PAO1 in complex with the cofactor pyridoxal 5'-phosphate (PLP) and product UDP-GlcNAc(3NH(

141 corated with the vitamin B(6) cofactors like pyridoxal 5'-phosphate (PLP) and pyridoxal (Py) by formi

142 Pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phospha

143 ian HAD phosphatase known to dephosphorylate pyridoxal 5'-phosphate (PLP) and serine/threonine-phosph

144 Low plasma concentrations of pyridoxal 5'-phosphate (PLP) are common in renal transpl

145 In this study, we characterized the pyridoxal 5'-phosphate (PLP) biosynthesis pathway in Str

146 The enzyme is a homodimer with one pyridoxal 5'-phosphate (PLP) bound per subunit deep with

147 The accumulating P6C inactivates pyridoxal 5'-phosphate (PLP) by forming a Knoevenagel co

148 CBS contains a pyridoxal 5'-phosphate (PLP) cofactor which catalyzes th

149 no longer makes a Schiff base linkage to the pyridoxal 5'-phosphate (PLP) cofactor, and instead the c

150 tion from an adenosylcobalamin (AdoCbl) to a pyridoxal 5'-phosphate (PLP) cofactor.

151 bstrate on the internal aldimine form of the pyridoxal 5'-phosphate (PLP) cofactor.

152 PNPO activity was quantified by measuring pyridoxal 5'-phosphate (PLP) concentrations in a DBS bef

153 decreased erythrocyte PDXK activity and low pyridoxal 5'-phosphate (PLP) concentrations.

154 BioA, a pyridoxal 5'-phosphate (PLP) dependent aminotransferase,

155 lopropane-1-carboxylate (ACC) deaminase is a pyridoxal 5'-phosphate (PLP) dependent enzyme catalyzing

156 Ornithine decarboxylase (ODC) is a pyridoxal 5'-phosphate (PLP) dependent enzyme that catal

157 lopropane-1-carboxylate (ACC) deaminase is a pyridoxal 5'-phosphate (PLP) dependent enzyme which cata

158 DDC is a pyridoxal 5'-phosphate (PLP) dependent enzyme.

159 ytically diverse but structurally homologous pyridoxal 5'-phosphate (PLP) dependent enzymes known as

160 Both of these enzymes are pyridoxal 5'-phosphate (PLP) dependent, and their three-

161 (SGAT) from Hyphomicrobium methylovorum is a pyridoxal 5'-phosphate (PLP) enzyme that catalyzes the i

162 CBS uses coenzyme pyridoxal 5'-phosphate (PLP) for catalysis, and S-adenos

163 le-enzyme biosynthetic pathway that produces pyridoxal 5'-phosphate (PLP) from glutamine, ribose 5-ph

164 sma concentrations of the vitamin B-6 marker pyridoxal 5'-phosphate (PLP) have been associated with r

165 ired for synthesis of the essential cofactor pyridoxal 5'-phosphate (PLP) in Escherichia coli Surpris

166 Vitamin B-6 status is routinely measured as pyridoxal 5'-phosphate (PLP) in plasma.

167 Pyridoxal 5'-phosphate (PLP) is a fundamental, multifunc

168 nic modulation in aspartate aminotransferase.Pyridoxal 5'-phosphate (PLP) is a ubiquitous co factor f

169 initiated by a transamination step in which pyridoxal 5'-phosphate (PLP) is converted to pyridoxamin

170 ine and erythrocytes, and among these plasma pyridoxal 5'-phosphate (PLP) is most commonly used.

171 Pyridoxal 5'-phosphate (PLP) is the active vitamer of vi

172 Pyridoxal 5'-phosphate (PLP) is the biologically active

173 tonation and H-bonded states of the cofactor pyridoxal 5'-phosphate (PLP) linked as an internal aldim

174 uced during the regeneration of the cofactor pyridoxal 5'-phosphate (PLP) of OAT by an unamplified mo

175 , the dimeric SufS protein uses the cofactor pyridoxal 5'-phosphate (PLP) to abstract sulfur from fre

176 cluster, S-adenosyl-L-methionine (SAM), and pyridoxal 5'-phosphate (PLP) to isomerize L-alpha-lysine

177 semialdehyde with concomitant conversion of pyridoxal 5'-phosphate (PLP) to pyridoxamine 5'-phosphat

178 ysis of the Schiff base linking the coenzyme pyridoxal 5'-phosphate (PLP) to the polypeptide is much

179 t was formed from SADTA covalently linked to pyridoxal 5'-phosphate (PLP) while the other adduct was

180 acidity of alpha-amino acids by the cofactor pyridoxal 5'-phosphate (PLP) with an unusual, unprotonat

181 The enzyme activity was dependent on pyridoxal 5'-phosphate (PLP), and C18-S-ACP was the pref

182 The active site contains a cofactor, pyridoxal 5'-phosphate (PLP), and the product phosphonoa

183 en plasma folate, vitamin B-6 in the form of pyridoxal 5'-phosphate (PLP), and total B-12 with serum

184 The most common status marker, plasma pyridoxal 5'-phosphate (PLP), decreases during inflammat

185 s in vitamin B(6) salvage pathway to produce pyridoxal 5'-phosphate (PLP), the active form of the vit

186 We hypothesized a relationship between pyridoxal 5'-phosphate (PLP), the active form of vitamin

187 Pyridoxal 5'-phosphate (PLP), the active form of vitamin

188 me in converting dietary vitamin B6 (VB6) to pyridoxal 5'-phosphate (PLP), the biologically active fo

189 In Escherichia coli, the synthesis of pyridoxal 5'-phosphate (PLP), the catalytically active f

190 ogy of vitamin B-6 status with use of plasma pyridoxal 5'-phosphate (PLP), the indicator of vitamin B

191 and responsible for the de novo synthesis of pyridoxal 5'-phosphate (PLP), the major active form of v

192 An insufficiency of cellular pyridoxal 5'-phosphate (PLP), which is the coenzyme form

193 in part by alanine racemase (EC 5.1.1.1), a pyridoxal 5'-phosphate (PLP)-assisted enzyme.

194 YggS/Ybl036c/PLPBP family includes conserved pyridoxal 5'-phosphate (PLP)-binding proteins that play

195 lix DNA-binding domain and a long C-terminal pyridoxal 5'-phosphate (PLP)-binding putative aminotrans

196 A) accumulates and inactivates at least some pyridoxal 5'-phosphate (PLP)-containing enzymes in Salmo

197 ng a protein with sequence similarity to the pyridoxal 5'-phosphate (PLP)-dependent 1-aminocyclopropa

198 due to mechanism-based inhibition of BioA, a pyridoxal 5'-phosphate (PLP)-dependent aminotransferase.

199 rst step in mammalian heme biosynthesis, the pyridoxal 5'-phosphate (PLP)-dependent and reversible re

200 Radiation of the plant pyridoxal 5'-phosphate (PLP)-dependent aromatic l-amino

201 Pyridoxal 5'-phosphate (PLP)-dependent basic amino acid

202 the final step of cysteine biosynthesis, the pyridoxal 5'-phosphate (PLP)-dependent conversion of O-a

203 S cluster assembly complex is a low-activity pyridoxal 5'-phosphate (PLP)-dependent cysteine desulfur

204 platinum-cysteine S-conjugate followed by a pyridoxal 5'-phosphate (PLP)-dependent cysteine S-conjug

205 rine dehydratase, EC 4.3.1.17) catalyzes the pyridoxal 5'-phosphate (PLP)-dependent dehydration of L-

206 eme-synthesizing organisms, results from the pyridoxal 5'-phosphate (PLP)-dependent enzymatic condens

207 h features a two-enzyme catalytic cascade, a pyridoxal 5'-phosphate (PLP)-dependent enzyme (Fub7), an

208 The two half-reactions of the pyridoxal 5'-phosphate (PLP)-dependent enzyme dialkylgly

209 Glycine decarboxylase, or P-protein, is a pyridoxal 5'-phosphate (PLP)-dependent enzyme in one-car

210 thionine beta-synthase (CBS) is an essential pyridoxal 5'-phosphate (PLP)-dependent enzyme of the tra

211 O-Acetylserine sulfhydrylase is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catal

212 l-lyase (TPL) from Citrobacter freundii is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catal

213 Ornithine decarboxylase (ODC) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catal

214 Serine hydroxymethyltransferase (SHMT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catal

215 butyric acid aminotransferase (GABA-AT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degra

216 ystathionine beta-synthase (CBS) is a unique pyridoxal 5'-phosphate (PLP)-dependent enzyme that has a

217 ptophan indole-lyase (Trpase) is a bacterial pyridoxal 5'-phosphate (PLP)-dependent enzyme which cata

218 olevulinate synthase (EC 2.3.1.37) (ALAS), a pyridoxal 5'-phosphate (PLP)-dependent enzyme, catalyzes

219 rine sulfydrylase (OASS), a highly conserved pyridoxal 5'-phosphate (PLP)-dependent enzyme, present i

220 biotin biosynthesis is performed by BioA, a pyridoxal 5'-phosphate (PLP)-dependent enzyme.

221 Pyridoxal 5'-phosphate (PLP)-dependent enzymes utilize t

222 ber of the alpha-oxoamine synthase family of pyridoxal 5'-phosphate (PLP)-dependent enzymes.

223 CsdB protein is a member of the homodimeric pyridoxal 5'-phosphate (PLP)-dependent family of enzymes

224 The three-dimensional structure of the pyridoxal 5'-phosphate (PLP)-dependent L-threonine-O-3-p

225 e and serine to their other chiral form in a pyridoxal 5'-phosphate (PLP)-dependent manner.

226 The pyridoxal 5'-phosphate (PLP)-dependent S-selective trans

227 re generated as mechanistic intermediates of pyridoxal 5'-phosphate (PLP)-dependent serine/threonine

228 focused on the dehydration of serine by the pyridoxal 5'-phosphate (PLP)-dependent serine/threonine

229 Herein it is demonstrated that AbmH is a pyridoxal 5'-phosphate (PLP)-dependent transaldolase tha

230 The pyridoxal 5'-phosphate (PLP)-dependent transaminase BioA

231 ct distribution generated upon reaction with pyridoxal 5'-phosphate (PLP).

232 sylmethionine (SAM), a [4Fe-4S] cluster, and pyridoxal 5'-phosphate (PLP).

233 g leads including nucleotide analogs such as pyridoxal 5'-phosphate (PLP).

234 r 5,6-LAM are adenosylcobalamin (AdoCbl) and pyridoxal 5'-phosphate (PLP).

235 ms, most notable among which is the cofactor pyridoxal 5'-phosphate (PLP).

236 e kynurenine pathway includes 2 vitamin B-6 [pyridoxal 5'-phosphate (PLP)]-dependent enzymes.

237 Enzymes dependent on pyridoxal 5'-phosphate (PLP, the active form of vitamin

238 Pyridoxal 5'-phosphate (PLP, vitamin B6), a cofactor in

239 valuated the relation between plasma folate, pyridoxal 5'-phosphate (PLP; the biologically active for

240 Pyridoxal 5'-phosphate (PLP; vitamin B(6))-catalyzed rea

241 d to assess HTPO inhibition as a function of pyridoxal 5-phosphate (PLP) concentration.

242 B-6 restriction significantly reduced plasma pyridoxal 5-phosphate (PLP) concentrations (55.1 +/- 8.3

243 Pyridoxal 5-phosphate (PLP), the phosphorylated and the

244 ein is dimeric and adopts the type I-fold of pyridoxal 5-phosphate (PLP)-dependent aminotransferases.

245 I reveals that it belongs to the fold-type I pyridoxal 5-phosphate (PLP)-dependent enzymes.

246 This pyridoxal 5-phosphate (PLP)-dependent reaction is mediat

247 y evaluated plasma concentrations of folate, pyridoxal 5-phosphate (PLP; the principal active form of

248 erase (GABA-AT; GabT) upon interactions with pyridoxal-5'-phosphate (PLP) and GABA, and thereby promo

249 the cofactors adenosylcobalamin (AdoCbl) and pyridoxal-5'-phosphate (PLP) and the substrate into prox

250 coli, purified to homogeneity, shown to bind pyridoxal-5'-phosphate (PLP) and to catalyze cysteine de

251 ino acid and nucleotide metabolism, and uses pyridoxal-5'-phosphate (PLP) as a cofactor.

252 es of serum carotenoids, retinyl esters, and pyridoxal-5'-phosphate (PLP) by using high-pressure liqu

253 al clinical observation of isolated cases of pyridoxal-5'-phosphate (PLP) deficiency, this prospectiv

254 Circulating pyridoxal-5'-phosphate (PLP) has been linked to lung can

255 Two routes for the de novo biosynthesis of pyridoxal-5'-phosphate (PLP) have been discovered and re

256 Pyridoxal-5'-phosphate (PLP) is introduced to a biomimet

257 Vitamin B-6 as pyridoxal-5'-phosphate (PLP) is required as the coenzyme

258 Pyridoxal-5'-phosphate (PLP) is the biologically active

259 nthase (ACS) in complex with either cofactor pyridoxal-5'-phosphate (PLP) or both PLP and inhibitor a

260 nents of vitamin B6 i.e. pyridoxine (Py) and pyridoxal-5'-phosphate (PLP) using the same MIP format.

261 o rapid in vivo dissociation of its cofactor pyridoxal-5'-phosphate (PLP), a surprising finding, beca

262 The protein LpThi5 is a dimer that binds pyridoxal-5'-phosphate (PLP), apparently without a solve

263 expressed in Pichia pastoris, contains bound pyridoxal-5'-phosphate (PLP), but does not catalyze the

264 The x-ray crystal structure of the pyridoxal-5'-phosphate (PLP), S-adenosyl-L-methionine (S

265 The group IV pyridoxal-5'-phosphate (PLP)-dependent decarboxylases be

266 This first step is catalyzed by the pyridoxal-5'-phosphate (PLP)-dependent enzyme serine pal

267 spartate 4-carboxylyase, E.C. 4.1.1.12) is a pyridoxal-5'-phosphate (PLP)-dependent enzyme that catal

268 Kynureninase [E.C. 3.7.1.3] is a pyridoxal-5'-phosphate (PLP)-dependent enzyme that catal

269 Human cystathionine-gamma-lyase (CGL) is a pyridoxal-5'-phosphate (PLP)-dependent enzyme, which fun

270 eso-diaminopimelate decarboxylase (DAPDC), a pyridoxal-5'-phosphate (PLP)-dependent enzyme.

271 acid-base chemistry that drives catalysis in pyridoxal-5'-phosphate (PLP)-dependent enzymes has been

272 Cysteine desulfurases (CDs) are pyridoxal-5'-phosphate (PLP)-dependent enzymes that clea

273 transformations of amino acids performed by pyridoxal-5'-phosphate (PLP)-dependent enzymes.

274 f 5,6-LAM are 5'-deoxyadenosylcobalamin- and pyridoxal-5'-phosphate (PLP)-dependent.

275 , vitamin B6 [whose main circulating form is pyridoxal-5'-phosphate (PLP)], vitamin B12, and homocyst

276 The pyridoxal-5-phosphate (PLP) molecule bonded tightly to L

277 the active form of vitamin B6 (also known as pyridoxal 5'-phosphate [PLP]), in complex with artesunat

278 cysteine, folate and vitamin B6 (active form pyridoxal 5'-phosphate, PLP), we conducted a meta-analys

279 significantly decreased levels of pyridoxal, pyridoxal 5'-phosphate, pyridoxamine, and pyridoxamine 5

280 We propose that pyridoxal-5-phosphate regulates Na(+) and K(+) homeostas

281 demonstrate that modification of Lys-1699 by pyridoxal 5'-phosphate results in a specific decrease in

282 hosphates and plays an important role in the pyridoxal 5' phosphate salvage pathway.

283 ional change that releases strain in the Lys pyridoxal 5'-phosphate Schiff base and increases the pK(

284 rspermidine in CANSDC, form a Schiff base to pyridoxal 5'-phosphate, suggesting that the product comp

285 The orientation of the bound pyridoxal 5'-phosphate suggests that the enzyme catalyze

286 Along with pyridoxal 5'-phosphate synthases and aryl nitroreductase

287 gher levels of pyridoxine, pyridoxamine, and pyridoxal 5'-phosphate than the wild type, reflected in

288 The results show that the pool of pyridoxal 5'-phosphate that is not bound to proteins is

289 an essential enzyme (pdxB) in production of pyridoxal 5'-phosphate (the active form of Vitamin B6),

290 the oxidation of pyridoxine 5'-phosphate to pyridoxal 5'-phosphate, the active cofactor form of vita

291 Bacillus subtilis synthesizes pyridoxal 5'-phosphate, the active form of vitamin B(6),

292 vealed this transformation is dependent upon pyridoxal-5'-phosphate, the enzyme has no activity with

293 ase contains a non-catalytic site that binds pyridoxal 5'-phosphate tightly.

294 C) impairs binding of the essential cofactor pyridoxal 5'-phosphate to ALAS2, resulting in destabiliz

295 Pyrococcus horikoshii was transaminated with pyridoxal-5'-phosphate to produce a ketone-bearing prote

296 ase, an enzyme involved in the catabolism of pyridoxal 5'-phosphate (vitamin B 6).

297 dc), an enzyme involved in the catabolism of pyridoxal 5'-phosphate (Vitamin B6).

298 Pyridoxal-5'-phosphate (vitamin B(6) ) is an essential c

299 partial inhibition by substrate, and excess pyridoxal 5'-phosphate was found to be inhibitory.

300 6 phosphorylation, producing the active form pyridoxal 5'-phosphate, which regulates two key metaboli