ライフサイエンスコーパス: pyrin

1 familial Mediterranean fever disease protein Pyrin.

2 es PKN1 and PKN2 that bind and phosphorylate pyrin.

3 The B30.2 domain also negatively regulates pyrin.

4 tment domain, and the innate immune receptor pyrin.

5 Pyrin, a protein of 781 aa with pyrin domain at the N-te

6 um difficile and its enterotoxin A (TcdA) as Pyrin-activating agents and show that wild-type and FMF

7 urther demonstrate that microtubules control Pyrin activation downstream of Pyrin dephosphorylation a

8 results are consistent with a model in which pyrin acts to limit the release of IL-1beta generated by

9 By immunoblotting pyrin after infection, we observed that wt YopE triggere

10 omain modulates pUL83-mediated inhibition of pyrin aggregation.

11 The mechanism by which mutations in pyrin alter protein function to cause episodic inflammat

12 of-function mutations in MEFV, which encodes pyrin, an inflammasome protein.

13 r small interfering RNA against pyrin or YFP-pyrin and ASC (YFP-ASC) were infected with B. cenocepaci

14 tions of Mediterranean fever (MEFV) encoding pyrin and characterized by inflammatory attacks induced

15 rich repeat-containing receptors (NLRs), and pyrin and HIN domain (PYHIN) families.

16 e pathways, cGMP-AMP synthase (cGAS) and the pyrin and HIN domain family member (PYHIN) protein inter

17 An intramolecular complex of the AIM2 Pyrin and HIN domains in an autoinhibited state is liber

18 repeat-containing) superfamily or the PYHIN (PYRIN and HIN-200 domain-containing) superfamily.

19 Mutations in the genes encoding pyrin and mevalonate kinase (MVK) cause distinct interle

20 REDD1 in autolysosomes colocalizes with pyrin and nucleotide-binding domain, leucine-rich repeat

21 Knockdown of pyrin and selective inhibition of p38 MAPK greatly atten

22 s how various convergent pathways, including pyrin and the actin cytoskeleton, protein misfolding and

23 We transfected HEK293T cells with pyrin and wild-type and mutated WDR1 Mutant protein form

24 Mutations in the gene encoding pyrin are associated with autoinflammatory disorder Fami

25 ating agents and show that wild-type and FMF Pyrin are differentially controlled by microtubules.

26 ons in the Mediterranean fever gene (MEFV or pyrin) are associated with hereditary autoinflammatory d

27 Molecular docking of pyrin-ASC PYD complexes showed that pyrin PYD can simult

28 onuclear cells infected with B. cenocepacia, pyrin associates with caspase-1 and ASC forming an infla

29 which an evolutionarily conserved N-terminal pyrin association domain (PAD) binds IFI16.

30 to phagocytes and interact with the RhoA-PRK-pyrin axis during infection.

31 eraction with ASC, it also bound less to the pyrin B-box domain responsible for autoinhibition and he

32 ies with human phagocytes and mice producing pyrin B30.2 FMF variants show that gain of function MEFV

33 Phosphorylated pyrin bound to 14-3-3 proteins, regulatory proteins that

34 sed by mutations in the inflammasome adaptor Pyrin, but how FMF mutations alter signaling in FMF pati

35 RhoA-modifying toxins trigger activation of pyrin by a conserved dephosphorylation mechanism.

36 Binding of ASC to pyrin by a PYD-PYD interaction triggers inflammasome ass

37 ivating toxin, triggers activation of murine pyrin by dephosphorylation of Ser205 and Ser241.

38 third effector, YopM, binds to and inhibits pyrin by hijacking PRK and RSK and directing linker phos

39 of another effector, YopM, which counteracts pyrin by keeping it inactive.

40 kinases PRK1 and PRK2 to negatively regulate pyrin by phosphorylation.

41 Inhibition of pyrin by YopM is required for virulence of Yersinia pest

42 Wild-type human pyrin can also form an inflammasome complex with ASC aft

43 Expression of pyrin can be induced by LPS and cytokines, and IL-10 is

44 Furthermore, fibers of recombinant PYRIN can convert ASC into functional polymers capable o

45 ASC PYD can self-associate and interact with pyrin, consistent with previous reports that pyrin promo

46 otide-binding domain and leucine rich repeat pyrin containing 1b (NLRP1b) inflammasome was identified

47 e-binding domain, leucine-rich family (NLR), pyrin-containing 3 (NLRP3) inflammasome has received muc

48 ed that inflammasome activation by BAA473 is pyrin-dependent (MEFV).

49 bules control Pyrin activation downstream of Pyrin dephosphorylation and that FMF mutations enable mi

50 RIPK3 did not affect pyrin dephosphorylation associated with inflammasome act

51 We also observed that wt YopT triggered pyrin dephosphorylation but more slowly than YopE, sugge

52 Pyrin dephosphorylation was reduced if a YopE variant ha

53 To determine if YopE or YopT triggers pyrin dephosphorylation, we infected lipopolysaccharide

54 s RhoA specificity, affect the efficiency of pyrin dephosphorylation.

55 It is composed of an N-terminal pyrin domain (PYD) and a C-terminal caspase recruitment

56 hich consists of two domains, the N-terminal pyrin domain (PYD) and the C-terminal CARD.

57 izing double-stranded DNA and its N-terminal pyrin domain (PYD) for eliciting downstream effects thro

58 ary inflammasome complexes, achieved through pyrin domain (PYD) interactions between sensors and ASC

59 otein ASC and initiate polymerization of its pyrin domain (PYD) into filaments.

60 on dsDNA engagement, the AIM2 amino-terminal pyrin domain (PYD) is responsible for downstream signali

61 rk of highly intercrossed filaments, whereas pyrin domain (PYD) or caspase activation and recruitment

62 three-dimensional homology model of the M013 pyrin domain (PYD) was built based on similarities to kn

63 Key domains in pyrin include a pyrin domain (PYD), a linker region, and a B30.2 domain.

64 ng studies on human growth hormone (hGH) and pyrin domain (PYD), and the results show how mutations a

65 uman NLRP1, mouse NLRP1b lacks an N-terminal pyrin domain (PYD), indicating that the assembly of the

66 Inflammasome assembly requires the PYRIN domain (PYD)-containing adaptor ASC, and depends o

67 Here we identified the PYRIN domain (PYD)-only protein POP3, which competes wit

68 tion is controlled by phosphorylation of its pyrin domain (PYD).

69 sent cryo-EM and crystal structures of NLRP6 pyrin domain (PYD).

70 nod-like receptor family member containing a pyrin domain 3 (NLRP3) inflammasome in a protracted mann

71 diated by the NOD-like receptor containing a pyrin domain 3 (NLRP3) inflammasome, although exactly ho

72 gomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasomes and induces the rel

73 delayed activation of the cytosolic PRR NLR pyrin domain 3 (NLRP3) that would otherwise amplify the

74 he absence of Nod-like receptor containing a pyrin domain 3 and absent in melanoma 2.

75 elanoma 2 and Nod-like receptor containing a pyrin domain 3 are partially required for caspase-1 acti

76 otide-binding domain and leucine-rich repeat pyrin domain 3 are simultaneously present in the same in

77 d ability to bind Sp1 require the N-terminal pyrin domain and nuclear localization of IFI16, but not

78 ein containing a caspase recruitment domain) pyrin domain and the IFI16-double stranded DNA complex h

79 Pyrin, a protein of 781 aa with pyrin domain at the N-terminal, negatively regulates inf

80 gomerization domain, leucine rich repeat and pyrin domain containing 1 (NLRP1), NLRP3, and nucleotide

81 these sensors, including NLRP1 (NLR family, pyrin domain containing 1), are described to form an inf

82 ng the NOD-like receptor NLRP10 (NLR family, pyrin domain containing 10); however, the mechanism by w

83 merization domain (NOD)-like receptor family pyrin domain containing 12 (NLRP12) plays a protective r

84 yrin domain containing 3 (NLRP3), NLR family pyrin domain containing 2 (NLRP2), AIM2 (absent in melan

85 uble deficiency of Nod like receptor family, pyrin domain containing 3 (NLRP3) and caspase 8 inPstpip

86 n mutations in the NOD-like receptor family, pyrin domain containing 3 (NLRP3) gene, which cause unco

87 In this context, NLR family pyrin domain containing 3 (NLRP3) inflammasome activatio

88 turn, decreases TXNIP-stimulated NLR family pyrin domain containing 3 (NLRP3) inflammasome activatio

89 ts are mediated by NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activatio

90 n and leucine rich repeat containing family, pyrin domain containing 3 (NLRP3) inflammasome as an ess

91 ding domain, leucine-rich-containing family, pyrin domain containing 3 (NLRP3) inflammasome complex a

92 cell sensor leucine-rich-containing family, pyrin domain containing 3 (NLRP3) inflammasome controls

93 ortant role of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome for media

94 NLR family pyrin domain containing 3 (NLRP3) inflammasome has been

95 is a key to induce NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in macrop

96 itin, activate the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in primed

97 oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome into a ma

98 Excessive activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is involv

99 leucine-rich repeat containing gene family, pyrin domain containing 3 (NLRP3) inflammasome to induce

100 r activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome to trigge

101 The NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, a multip

102 oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome-dependent

103 of Tat in priming and activating NLR family pyrin domain containing 3 (NLRP3) inflammasomes in micro

104 ammasome system, mediated by the NLR family, pyrin domain containing 3 (NLRP3) initiating protein, wa

105 NOD-like receptor family, pyrin domain containing 3 (NLRP3) protein is a key compo

106 components of the NOD-like receptor family, pyrin domain containing 3 (NLRP3), and absent in melanom

107 de-binding domain, leucine rich family (NLR) pyrin domain containing 3 (NLRP3), NLR family pyrin doma

108 n and leucine rich repeat containing family, pyrin domain containing 3 (NLRP3).

109 Activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3)/caspase-1 inflammasome

110 gomerization domain, leucine-rich repeat and pyrin domain containing 3 (NRLP3) inflammasome members (

111 erization domain (NOD)-like receptor family, pyrin domain containing 3 activation in the inflammasome

112 tightly regulating NOD-like receptor family, pyrin domain containing 3 activation.

113 rich repeat-containing-like receptor family, pyrin domain containing 3 and autophagosome-associated m

114 rvention targeting NOD-like receptor family, pyrin domain containing 3 inflammasome activity induces

115 he key role of the NOD-like receptor family, pyrin domain containing 3 inflammasome during acute pneu

116 n regulate hepatic steatosis; the NLR family pyrin domain containing 3 inflammasome is critically inv

117 he activity of the NOD-like receptor family, pyrin domain containing 3 inflammasome when compared wit

118 ypoxia activate the NOD-like receptor family pyrin domain containing 3 inflammasome.

119 IL-1beta-producing NOD-like receptor family pyrin domain containing 3 inflammasome.

120 otide-binding domain and leucine-rich repeat pyrin domain containing 3 inflammasome.

121 omain leucine-rich repeat containing family, pyrin domain containing 3) inflammasome complex, assembl

122 The NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome is a multiprotei

123 flammasomes, and that the NLRP3 (NLR family, pyrin domain containing 3) inflammasome is not involved

124 OD2 target, NLRP3 (NOD-like receptor family, pyrin domain containing 3) is of importance in the patho

125 also causes NLRP3 (NOD-like receptor family pyrin domain containing 3) translocation from endoplasmi

126 spase-1, and NLRP3 (NOD-Like Receptor family Pyrin domain containing 3).

127 eased expression of inflammatory (NLR family pyrin domain containing 3, interleukins 1beta and 6, and

128 rich repeat-containing-like receptor family, pyrin domain containing 3-associated inflammasomes and i

129 e-1/Caspase-4- and NOD-like receptor family, pyrin domain containing 3-dependent inflammatory cell de

130 ce deficient in the NOD-like receptor family pyrin domain containing 6 (NLRP6) inflammasome feature e

131 NOD-like family pyrin domain containing 6 (NLRP6) is one of the 14 pyrin

132 g oligomerization domain (NOD)-like receptor pyrin domain containing family of gene 12 (Nlrp12) are a

133 salivary levels of nod-like receptor family pyrin domain containing protein (NLRP) 3, apoptosis-asso

134 tide-binding domain, leucine-rich repeat and pyrin domain containing protein (NLRP) family, which for

135 leotide-binding domain, leucine-rich repeat, pyrin domain containing protein 3 (NLRP3) inflammasome.

136 tly demonstrated that the NOD-like receptor, pyrin domain containing-3 (NLRP3) contributes to renal i

137 nding domain leucine-rich repeat containing, Pyrin domain containing-3 and for absent in melanoma 2 i

138 nding domain leucine-rich repeat containing, Pyrin domain containing-3 inflammasome, and caspase-4 ph

139 ting a role for the NOD-like receptor family pyrin domain containing-3 inflammasome.

140 We show here that the pyrin domain of AIM2 (AIM2(PYD)) drives both filament fo

141 VHHASC leaves the Pyrin domain of ASC functional and stabilizes a filament

142 on the recent near-atomic structures of the PYRIN domain of ASC in the protein filament of inflammas

143 weak affinity, and it is the non-DNA-binding pyrin domain of IFI16 that drives the cooperative filame

144 A-mediated) dephosphorylation of Ser5 in the pyrin domain of NLRP3.

145 The surface residues on the pyrin domain that mediate the cooperative DNA binding ar

146 unexpected auto-inhibitory function for the pyrin domain, and provide the first genetic evidence lin

147 this response by interacting with the IFI16 pyrin domain, blocking its oligomerization upon DNA sens

148 de-Binding Domain Leucine-Rich Repeat Family Pyrin Domain-Containing 1.

149 -1beta dependent on NOD-like receptor family pyrin domain-containing 3 (NLRP3) and ASC due to the sec

150 ndings support redundant roles of NLR family pyrin domain-containing 3 (NLRP3) and caspase-1 with cas

151 mutations in NOD-like receptor (NLR) family, pyrin domain-containing 3 (NLRP3) cause neonatal-onset m

152 oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome and conco

153 main, leucine-rich repeat-containing family, pyrin domain-containing 3 (NLRP3) inflammasome as well a

154 oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome drives ma

155 The NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been

156 The NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome is a casp

157 omain-like receptor, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome is now no

158 g oligomerization domain-like receptor (NLR) pyrin domain-containing 3 (Nlrp3) inflammasome is though

159 leucine-rich repeat containing family (NLR), pyrin domain-containing 3 (NLRP3) inflammasome plays a k

160 The NLR family pyrin domain-containing 3 (NLRP3) inflammasome plays an

161 studies of its regulation of the NLR family, pyrin domain-containing 3 (NLRP3) inflammasome.

162 cleotide-binding domain, leucine-rich repeat pyrin domain-containing 3 (NLRP3) inflammasome.

163 oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome.

164 In this study, we showed that NLR family pyrin domain-containing 3 (Nlrp3) is required to induce

165 n (ASC) inflammasomes, including NLR family, pyrin domain-containing 3 (NLRP3), but not NLR family, c

166 ts, including NOD-like receptor (NLR) family pyrin domain-containing 3 (NLRP3), NLRP1, NLR family CAR

167 ng and oligomerization, leucine-rich repeat, pyrin domain-containing 3 (NLRP3), simultaneously and di

168 direct roles of MIF in supporting NLR Family Pyrin Domain-Containing 3 (NRLP3) inflammasome activatio

169 otide-binding oligomerization domain family, pyrin domain-containing 3 inflammasome activation upon H

170 is detected by the NOD-like receptor family, pyrin domain-containing 3 inflammasome and can trigger a

171 tor 4 and prime the nod-like receptor family pyrin domain-containing 3 inflammasome in naive neutroph

172 ream mediators (eg, nod-like receptor family pyrin domain-containing 3 inflammasome, interleukin-1bet

173 and activates the NOD-like receptor family, pyrin domain-containing 3 inflammasome.

174 oligomerization domain-like receptor family, pyrin domain-containing 3 inflammasome.

175 ncluding increased expression of NLR family, pyrin domain-containing 3 protein (NLRP3) and constituti

176 main, leucine-rich-repeat-containing family, pyrin domain-containing 3) inflammasome mediates product

177 cleotide-binding domain, leucine-rich repeat/pyrin domain-containing 3.

178 Host NOD-like receptor family pyrin domain-containing 6 (NLRP6) regulates innate immun

179 cruitment domain-containing 4 or NLR family, pyrin domain-containing 6, are required for triggering t

180 rodent NLRP1B (NACHT leucine-rich repeat and pyrin domain-containing protein 1B).

181 erization domain (NOD)-like receptor family, pyrin domain-containing protein 3 (Nlrp3) expression was

182 sed on the role of nod-like receptor family, pyrin domain-containing protein 3 (NLRP3) inflammasome a

183 The NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome i

184 The NACHT, LRR, and pyrin domain-containing protein 3 (NLRP3) inflammasome i

185 f components of the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome s

186 osolic contact, and activation of NLR family pyrin domain-containing protein 3 (NLRP3) inflammasomes

187 binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasomes

188 ide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3)- and pyrin-med

189 a programmed death ligand 1/NOD-, LRR-, and pyrin domain-containing protein 3 (PD-L1/NLRP3) inflamma

190 inding oligomerization-like receptor family, pyrin domain-containing protein 3) activation, either by

191 fic inhibition of the NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome as a CF

192 s that assembles an NLRP3 (NOD-like receptor pyrin domain-containing protein 3) inflammasome via a Ra

193 NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular s

194 with a specific inhibitor of NOD-, LRR-, and pyrin domain-containing protein 3.

195 The SREBP-induced NOD-like receptor family pyrin domain-containing protein inflammasome and its ins

196 e activation of the NOD-like receptor family pyrin domain-containing protein inflammasome in macropha

197 t nucleotide-binding leucine-rich repeat and pyrin domain-containing receptor 12 (NLRP12) impedes alt

198 domain containing 6 (NLRP6) is one of the 14 pyrin domain-containing receptors.

199 ding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome controls

200 ding domain, leucine-rich-containing family, pyrin domain-containing-3, and downstream mitogen-activa

201 ding domain, leucine-rich-containing family, pyrin domain-containing-3, and p38/extracellular signal-

202 ding domain, leucine-rich-containing family, pyrin domain-containing-3; hypoxia-inducible factor 1/2a

203 ty, de Almeida et al. (2015) report that the PYRIN domain-only protein (POP1) efficiently inhibits in

204 irus, M013 is a viral homologue of the viral pyrin domain-only protein (vPOP) family.

205 cent developments in elucidating the role of PYRIN domain-only proteins (POPs) and the related CARD-o

206 Pyrin domain-only proteins (POPs) are recently evolved,

207 teins that regulate the inflammasome, namely pyrin domain-only proteins (POPs), caspase activation re

208 e nucleotide oligomerization domain receptor pyrin-domain containing protein 3 (NLRP3) by Salmonella

209 e-rich repeat (LRR)-containing (NLR) family, pyrin-domain-containing 3 (NLRP3) inflammasome drives pa

210 ucine-rich-repeat-containing receptor (NLR), pyrin-domain-containing 3 (NLRP3) inflammasome in human

211 or domains, caspase recruitment domains, and pyrin domains (PYD).

212 Inflammasome assembly is mediated by pyrin domains (PYDs) and caspase recruitment domains, wh

213 ns of caspase recruitment domains (CARDs) or PYRIN domains (PYDs).

214 , which harbor essential N-terminal CARD and PYRIN domains, respectively.

215 ines, and IL-10 is a known potent inducer of pyrin expression in macrophages.

216 downregulates IL-10 and therefore decreases pyrin expression to promote inflammasome activation and

217 ata show that TNF is a critical modulator of pyrin expression, inflammasome activation, and pyrin-inf

218 lrp3 inflammasome in the lungs, also induced pyrin expression, which in turn suppressed inflammasome

219 LPS-mediated upregulation of IL-10 enhanced pyrin expression, which serves, particularly in later ph

220 binding domain and leucine-rich repeat (NLR) pyrin family domain 3 (NLRP3) inflammasome pathway influ

221 Pyrin forms an inflammasome when mutant or in response t

222 Here, we show that CARD and PYRIN function as bona fide prions in yeast and that the

223 r macrophages attenuated the upregulation of pyrin in alveolar macrophages and lung endothelial cells

224 may help to further unveil the importance of pyrin in gut homeostasis and autoimmune diseases.

225 Mutations in MEFV, the gene encoding pyrin in humans, are associated with the autoinflammator

226 We investigated the role of pyrin in intestinal homeostasis in mice.

227 ion domain can functionally replace CARD and PYRIN in mammalian cell signaling.

228 TNF signaling promoted the expression of pyrin in response to multiple stimuli and was required f

229 ally reconstitute signaling of NLRP3 and ASC PYRINs in mammalian cells.

230 Key domains in pyrin include a pyrin domain (PYD), a linker region, and

231 hagosomal degradation, its role in NLRP3 and pyrin inflammasome activation also provides an inherent

232 ssessed the contribution of TNF signaling to pyrin inflammasome activation and its consequent role in

233 of microtubules by colchicine also inhibited pyrin inflammasome activation by ribotoxic stress.

234 +) (Pro(2+)) influx kinetics during NLRP3 or Pyrin inflammasome activation in murine bone marrow-deri

235 -interacting protein kinase (RIPK) 3 impacts pyrin inflammasome activation independent of its role in

236 Remarkably, Pyrin inflammasome activation persisted upon microtubule

237 We surmise that pyrin inflammasome activation through microbiota-modifie

238 as sufficient to promote Mefv expression and pyrin inflammasome activation, highlighting the cross-ta

239 IDS, led to RhoA inactivation and consequent pyrin inflammasome activation.

240 k host kinases to inhibit effector-triggered pyrin inflammasome activation.

241 How the pyrin inflammasome is activated in the absence of diseas

242 te that ribotoxic stress activates the human pyrin inflammasome through a mechanism that requires p38

243 ic stress triggers the assembly of the human pyrin inflammasome, leading to ASC oligomerization and c

244 ation by pathogens was shown to activate the pyrin inflammasome, so our data now extend this guard hy

245 this recognition pathway by restricting the pyrin inflammasome, thus increasing bacterial fitness.

246 l death and the mTOR pathway to regulate the pyrin inflammasome, which can be harnessed for therapeut

247 in PYDs that mediates ASC recruitment to the pyrin inflammasome, which is implicated in the pathogene

248 we show that YopM specifically restricts the pyrin inflammasome, which is triggered by the RhoA-inact

249 responses and constitutive activation of the Pyrin inflammasome.

250 h and inflammation through activation of the Pyrin inflammasome.

251 regulatory proteins that in turn blocked the pyrin inflammasome.

252 stably reconstituted with components of the pyrin inflammasome.

253 as the first small molecules to activate the pyrin inflammasome.

254 y disorder mediated by autoactivation of the pyrin inflammasome.

255 tween the mTOR pathway and regulation of the pyrin inflammasome.

256 e the first small molecule activators of the pyrin inflammasome.

257 Pro(2+) influx after initiation of NLRP3 or Pyrin inflammasomes by nigericin (NG) or Clostridium dif

258 rin expression, inflammasome activation, and pyrin-inflammasomopathy.

259 Mutant pyrin interacts less avidly with Yersinia pestis virulen

260 Pyrin is a cytosolic pattern-recognition receptor that n

261 Pyrin is an inflammasome sensor that promotes caspase-1-

262 Pyrin is an innate immune sensor that forms an active in

263 Pyrin is an innate sensor that assembles into an inflamm

264 Pyrin is held in an inactive conformation by negative re

265 The MEFV gene encoding human pyrin is preferentially expressed in phagocytes.

266 regulator of neutrophil function upstream to pyrin, is involved in NET release and regulation of IL-1

267 uation of a yopM mutant is fully reversed in pyrin knockout mice, demonstrating that YopM inhibits py

268 Suppression of pyrin levels in monocytes and THP-1 cells reduced caspas

269 se microtubule assembly inhibitors prevented Pyrin-mediated caspase-1 activation and secretion of IL-

270 rin domain-containing protein 3 (NLRP3)- and pyrin-mediated inflammasome assembly, caspase activation

271 dies with DSS-induced colitis, we found that pyrin (MEFV) is required for inflammasome activation and

272 sociated with mutations in the gene encoding pyrin (MEFV).

273 The discovery that Pyrin mutations remove the obligatory requirement for mi

274 In contrast, overexpression of pyrin or ASC induced a robust IL-1beta response to B. ce

275 ment R-Smad signaling because the N-terminal Pyrin or C-terminal leucine-rich repeat domains were dis

276 ressing either small interfering RNA against pyrin or YFP-pyrin and ASC (YFP-ASC) were infected with

277 Mutated pyrin prohibits this colocalization, leading to higher I

278 pyrin, consistent with previous reports that pyrin promotes ASC clustering to form a proinflammatory

279 omerization domain, leucine-rich repeat, and pyrin protein 3 complex, CASP1, and IL-1beta (P < 0.05)

280 omerization domain, leucine-rich repeat, and pyrin protein 3 complex.

281 nock-in mouse strain that expresses chimeric pyrin protein with a V726A mutation (Mefv(V726A/V726A))

282 -knockin (FMF-KI) mice that express chimeric pyrin protein with FMF mutation (MefvV726A/V726A) exhibi

283 eted binding modes, involving three sites on pyrin PYD and two sites on ASC PYD.

284 cking of pyrin-ASC PYD complexes showed that pyrin PYD can simultaneously interact with up to three A

285 , on structural and functional properties of pyrin PYD were investigated.

286 We demonstrate that both the ASC and pyrin PYDs have multifaceted binding modes, involving th

287 have studied the interaction between ASC and pyrin PYDs that mediates ASC recruitment to the pyrin in

288 This review discusses current concepts of pyrin regulation and its interaction with Yersinia effec

289 Insights into pyrin regulation have come from studies of several Yersi

290 Mutations in MEFV (encoding human PYRIN) result in autoinflammatory familial Mediterranean

291 ammasome activation in response to canonical pyrin stimuli and in myeloid cells from FMF-KI mice.

292 P1 is an adaptor protein that interacts with PYRIN, the protein encoded by the Mediterranean Fever (M

293 ulence factor YopM than with wild-type human pyrin, thereby attenuating YopM-induced interleukin (IL)

294 ormed aggregates that appeared to accumulate pyrin; this could potentially precipitate inflammasome a

295 ckout mice, demonstrating that YopM inhibits pyrin to promote virulence.

296 s of myeloid lineage and encodes the protein pyrin/TRIM20/Marenostrin.

297 Two pathogenic pyrin variants independently arose >1,800 years ago.

298 -3 and PKN proteins to FMF-associated mutant pyrin was substantially decreased, and the constitutive

299 Modifications to RhoA are sensed by pyrin, which, once activated, assembles a caspase-1 infl

300 Human pyrin with gain-of-function mutations in its B30.2/SPRY