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1 mide fulfills the criteria for an endogenous pyrogen.
2  activation in response to cold challenge or pyrogen.
3 ified after a long search for the endogenous pyrogen.
4 ator of host defenses and a major endogenous pyrogen.
5 ibits the thermogenic response to endogenous pyrogens.
6 he febrile response to peripherally injected pyrogens.
7 hibitors suppress the fever induced by these pyrogens.
8 arities of signaling downstream of these two pyrogens.
9 and lyophilized preparation of Streptococcus pyrogenes.
10 e [LPS]) or endogenous (e.g., interleukin-1) pyrogen administration, while selective COX-2 inhibitors
11 ip with IL-1, itself an important endogenous pyrogen and a potent stimulus of IL-6 production.
12 popolysaccharide (LPS) is a potent exogenous pyrogen and produces anorexia via cytokine production.
13 erformance liquid chromatography (HPLC), and pyrogen and sterility assays, as well as determination o
14               Endotoxins also referred to as pyrogens are chemically lipopolysaccharides habitually f
15 s review, the discoveries made on endogenous pyrogens are revisited, with insights into the importanc
16 use, although it tested negative by standard pyrogen assays, it was associated with adverse events in
17 ignificantly reduced the febrile response to pyrogen, decreasing integrated tympanic membrane tempera
18 strate that IL-6 is a circulating endogenous pyrogen during LPS-induced fever, which acts in concert
19 duced by immune cells activated by exogenous pyrogens, e.g., lipopolysaccharides (LPS), released into
20            However, the source of endogenous pyrogen (eg, IL-1beta) and the signaling cascade leading
21                                     Sterile, pyrogen-free [(18)F]FHBG was produced routinely in good
22                               Final sterile, pyrogen-free formulation was provided in physiologic sal
23 ed a phase I/II trial (IND#70627) of sterile pyrogen-free I-methylene blue to identify sentinel nodes
24 imental procedure details the preparation of pyrogen-free NANPs, isolation of PBMCs from freshly coll
25 cted intraperitoneally at 1 microgram/mouse; pyrogen-free saline (PFS) was the vehicle and control so
26 ttle than in CD18(+) cattle by comparison to pyrogen-free saline (PFS)-inoculated control animals.
27 n (2 micrograms/kg; i.v.); controls received pyrogen-free saline (PFS).
28  with either PGE2 (0, 10, 100, or 500 ng) in pyrogen-free saline with 0.5% ethanol (5 microl) or CCK-
29 (0.1, 0.4, and 1.0 microg) or vehicle alone (pyrogen-free saline, 0.2 microl) were administered durin
30 -sufficient rabbit knee joints with 10 mg of pyrogen-free urate crystals and analyzed IL-8 levels, le
31  The five treatments included: 1) distilled, pyrogen-free water; 2) 8.5% (w/v) SBHAN; 3) 4.3% (w/v) S
32                                            A pyrogen-free, direct enzyme-catalyzed process for its ra
33                The level of secretion of the pyrogen IL-1beta was significantly lower in the presence
34  factor Junb and the gene Il1b, encoding the pyrogen IL-1beta, which macrophages express upon activat
35 dding prostaglandin E2 (PGE2), an endogenous pyrogen, in the extracellular medium.
36 n that the production of PGE2 in response to pyrogens is critically dependent on COX-2 expression.
37 ne whether this effect of IL-1beta, a potent pyrogen, is due to modification of body temperature.
38 polysaccharide (LPS), a well-known bacterial pyrogen, is recognized by several receptors, including t
39                       All preparations had a pyrogen level of <0.125 EU/mL and were determined to be
40 total immunereactivity, small animal safety, pyrogen level, sterility and radionuclidic purity.
41 ulator of the fever induced by the exogenous pyrogen lipopolysaccharide (LPS).
42 cal was found to contain < or =4 +/- 1 EU/mL pyrogens (n = 66); all samples examined were sterile.
43                                  Endotoxins, pyrogens of bacterial origin, are a significant threat i
44 fense through multiple mechanisms, including pyrogen production and cell death.
45 nce, as the principal endogenous circulating pyrogen responsible for activating CNS mechanisms in fev
46 ld less active than wild-type NOMV in rabbit pyrogen tests and in tumor necrosis factor alpha release
47      Therefore, expression of the endogenous pyrogen TNF-alpha is regulated by increments in core tem
48 uced fevers to fevers produced by endogenous pyrogens, we studied the thermal responses of COX-1- and
49      The terms "granulocytic" or "endogenous pyrogen" were used to describe substances with the biolo
50    Interleukin (IL)-1 is a potent endogenous pyrogen which causes fever when injected into a number o