ライフサイエンスコーパス: pyrophosphate

1 hate) was greater than eNPP activity (ATP -> pyrophosphate).

2 ATP, resulted in marked reduction of plasma pyrophosphate.

3 of thiamine monophosphate (TMP) to thiamine pyrophosphate.

4 s, including PA, lyso-PA, and diacylglycerol pyrophosphate.

5 is in an open conformation before release of pyrophosphate.

6 bitors and by the addition of geranylgeranyl pyrophosphate.

7 capping agents: bicarbonate, phosphate, and pyrophosphate.

8 of nucleotides and avoiding inhibition from pyrophosphate.

9 lyzes the mineralization inhibitor inorganic pyrophosphate.

10 s farnesyl diphosphate (FDP) and isopentenyl pyrophosphate.

11 PA2 or inhibition of LPA3, by diacylglycerol pyrophosphate.

12 n through accumulation of the TNAP substrate pyrophosphate.

13 by the synthetic phosphoantigen bromohydrin pyrophosphate.

14 induced by the Lxr inhibitor geranylgeranyl pyrophosphate.

15 phoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate.

16 te human HCT116 cells devoid of any inositol pyrophosphates.

17 refers inorganic polyphosphate over inositol pyrophosphates.

18 is subject to metabolite control by inositol pyrophosphates.

19 However, a separate inositol pyrophosphate, 1,5-bisdiphosphoinositol 2,3,4,6-tetrakis

20 ium oscillations, while other caged inositol pyrophosphates (3,5-(PP)(2)-InsP(4), 5-PP-InsP(5), 1-PP-

21 that synthesizes the intracellular inositol pyrophosphate 5-diphosphoinositol 1,2,3,4,6-pentakisphos

22 The inositol pyrophosphates 5-InsP7 (diphosphoinositol pentakisphosph

23 xerts its function through the generation of pyrophosphate, a key inhibitor of hydroxyapatite formati

24 re, adenosine triphosphate is converted into pyrophosphate, a major inhibitor of ectopic calcificatio

25 ned protein sensors that respond to farnesyl pyrophosphate, a metabolic intermediate in the productio

26 Geranylgeranyl pyrophosphate, a non-sterol intermediate of the mevalona

27 rder caused by reduced circulating levels of pyrophosphate, a potent mineralization inhibitor.

28 ranylgeranyl pyrophosphate, but not farnesyl pyrophosphate, abolished these anticontractile effects,

29 It is currently unknown how the release of pyrophosphate affects transcription.

30 To verify whether inositol pyrophosphates also regulate mammalian cellular phosphat

31 he first cycle and is rescued by isopentenyl pyrophosphate, an essential apicoplast product, confirmi

32 umulation of the phosphoantigens isopentenyl pyrophosphate and ApppI.

33 nal engagement of nisin with lipid II at the pyrophosphate and C-terminus of the pentapeptide chain.

34 A biomimetic route to farnesyl pyrophosphate and dimethyl orsellinic acid (DMOA)-derive

35 ogically involved in generation of inorganic pyrophosphate and inorganic phosphate, and the findings

36 te pathway to provide a high flux of geranyl pyrophosphate and introduced a heterologous, multi-organ

37 Additionally, orthophosphate, pyrophosphate and phosphonates were also detected.

38 MraYAA, including how it avoids the need for pyrophosphate and sugar moieties, which are essential fe

39 The position of the pyrophosphate and the unusual phosphodiester linkage bet

40 Erythrocyte thiamin pyrophosphate and urine thiamin concentrations were sign

41 producing (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate and vitamin B2, respectively.

42 ination of incomplete 5'-end caps (including pyrophosphate) and the non-canonical NAD+ cap on mRNAs,

43 This enzyme reversibly converts AMP, pyrophosphate, and phosphoenolpyruvate to ATP, orthophos

44 owed a three-fold enhancement of isopentenyl pyrophosphate, and targeting AACPR, DBR2, and CYP71AV1 t

45 basal P(i) efflux was stimulated by inositol pyrophosphates, and basal intracellular P(i) accumulated

46 ound capable of accommodating two trianionic pyrophosphate anions in the cavity.

47 Quantification of intracellular isopentenyl pyrophosphate/ApppI following ZOL treatment showed that

48 Inositol pyrophosphates are high energy signaling molecules invol

49 Inositol pyrophosphates are novel signaling molecules possessing

50 iphosphates (PP-IPs), also known as inositol pyrophosphates, are high-energy cellular signaling codes

51 polyphosphates, also referred to as inositol pyrophosphates, are important signaling molecules that r

52 allyl transferase utilizes 3,3-dimethylallyl pyrophosphate as a prenyl donor and prenylates resveratr

53 iac amyloidosis referred for technetium-99 m pyrophosphate at a single tertiary center from June 2015

54 translocated initiation complex that traps a pyrophosphate at the active site that remains closed.

55 g the enzymes exopolyphosphatase (polyP into pyrophosphate), ATP sulfurylase (pyrophosphate into ATP)

56 e is a functional interplay between inositol pyrophosphates, ATP, and polyP.

57 ased ratiometric sensor for Fe(III) ions and pyrophosphate based on Fe(III)-induced aggregation of th

58 a conformational selection mechanism as the pyrophosphate binds to a rare pretranslocation state of

59 ugh the inositol kinases underlying inositol pyrophosphate biosynthesis are well characterized, the p

60 tion of the kinases involved in the inositol pyrophosphate biosynthetic pathway in Trypanosoma brucei

61 However, we found that the pyrophosphate bond is relatively stable within an RNA du

62 magnesium cations results in cleavage of the pyrophosphate bond within minutes.

63 l signaling molecules possessing high-energy pyrophosphate bonds and involved in a number of biologic

64 5'-triphosphate (ATP) and ALP can hydrolysis pyrophosphate, both reactions produce phosphate ions, an

65 mentation with mevalonate and geranylgeranyl pyrophosphate, but not farnesyl pyrophosphate, abolished

66 NAMPT at His247, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition

67 noid carbon skeletons vary widely from neryl pyrophosphate (C10) to natural rubber (C>10,000).

68 is first (to our knowledge) study of (99m)Tc-pyrophosphate cardiac imaging using a novel cadmium-zinc

69 t fashion to both microbial and host-derived pyrophosphate compounds (phosphoantigens, or P-Ag).

70 roduction, and mineralization, and decreased pyrophosphate concentration in Hyp-derived osteocyte-lik

71 Here, we report that the pyrophosphate concentration is increased in Hyp bones, a

72 uppressed Tnap mRNA expression and increased pyrophosphate concentrations in the culture medium and i

73 Inositol pyrophosphates constitute a family of hyperphosphorylate

74 tors of Vgamma9Vdelta2 activation are small, pyrophosphate-containing molecules called phosphoantigen

75 Vgamma9/Vdelta2 T-cells are activated by pyrophosphate-containing small molecules known as phosph

76 udy tested the effect of adding tetra-sodium pyrophosphate, cystine and lysine as surimi gelation enh

77 Pyrophosphate deficiency may explain the excessive vascu

78 mine uptake and/or inhibition of the thiamin pyrophosphate-dependent enzymes using thiamine antagonis

79 tulose 1,7-bisphosphate (SBP) pathway, using pyrophosphate-dependent phosphofructokinase (PP(i)-PFK)

80 In the case of the thiamin pyrophosphate-dependent thiM riboswitch, we find that Rh

81 en phosphate flush occurred despite inositol pyrophosphate depletion.

82 ), spondyloarthropathy (n = 15), and calcium pyrophosphate deposition disease (CPPD) (n = 15), from t

83 ANKH mutations are associated with calcium pyrophosphate deposition disease and craniometaphyseal d

84 xpression-plasmids containing either calcium pyrophosphate deposition disease or craniometaphyseal dy

85 anoscale silicon dioxide (NanoSiO2), calcium pyrophosphate dihydrate (CPPD) crystals, and muramyl tri

86 f calcium oxalate, monosodium urate, calcium pyrophosphate dihydrate and cystine trigger caspase-inde

87 alcium oxalate, monosodium urate, or calcium pyrophosphate dihydrate, as well as silica microparticle

88 ntenyl pyrophosphate (IPP) to dimethyl allyl pyrophosphate (DMAPP) and vice versa.

89 lallyl monophosphate (DMAP) and dimethyallyl pyrophosphate (DMAPP) dependent UbiX enzymes, we reveal

90 entenyl pyrophosphate (IPP) to dimethylallyl pyrophosphate (DMAPP), with volatile isoprenoids contain

91 ntenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP).

92 Bloodstream forms unable to produce inositol pyrophosphates, due to downregulation of TbIPMK expressi

93 ies as orthophosphate (Bacillus subtilis) or pyrophosphate (Escherichia coli) triggers ribonucleolyti

94 (ADCs) beyond oncology indications, a novel pyrophosphate ester linker was discovered to enable the

95 fset by an increase of both ATP and inositol pyrophosphates, evidence for a model in which there is a

96 ralization associated with reduced inorganic pyrophosphate, failed to reduce muzzle skin mineralizati

97 Ferric pyrophosphate (FePP) is a widely used iron source in foo

98 ice is consumed as intact grains, and ferric pyrophosphate (FePP), which is usually used for rice for

99 d ferrous sulfate (FeSO4; study 1) or ferric pyrophosphate (FePP; study 2).

100 able plants to produce thiamine and thiamine pyrophosphate for growth and development.

101 [PSI+] prion variants require inositol poly-/pyrophosphates for their propagation, and at least IP6 o

102 al metal ion (product metal) associated with pyrophosphate formation, leading to the suggestion of it

103 sis of the wound-healing inhibitors farnesyl pyrophosphate (FPP) and cortisol, ligands for the glucoc

104 ting mevalonate pathway metabolites farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GG

105 gmentation of the metabolic flux to farnesyl pyrophosphate (FPP) by different FPP synthases conferred

106 biosynthesis of the C-15 isoprenoid farnesyl pyrophosphate (FPP).

107 Gpp synthesis by Rel involves transferring a pyrophosphate from ATP to the oxygen of 3'-OH of GTP/GDP

108 uranyl peroxide nanoclusters is reported for pyrophosphate-functionalized Na44K6[(UO2)24(O2)24(P2O7)1

109 adipocyte lipolysis, hydrolysis of inorganic pyrophosphate generated during synthesis of fatty acyl-c

110 of the metabolic intermediate geranylgeranyl pyrophosphate (GGPP) is required to specifically drive I

111 ons in UBIAD1, which utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin K(2).

112 ontaining protein-1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin K2 We previou

113 nesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP), which are used for protein prenyla

114 annosylation of the dolichol mimic, phytanyl pyrophosphate GlcNAc2.

115 The presence of the pyrophosphate group in these PAgs has limited their drug

116 uced and pyrophosphate hydrolysis (via TNAP; pyrophosphate -> phosphate) was increased in both aortas

117 dimethylorsellinic acid (DMOA) and farnesyl pyrophosphate have attracted much biosynthetic attention

118 -dimethylorsellinic acid (DMOA) and farnesyl pyrophosphate have not been reported despite heavy biosy

119 Inositol pyrophosphates have emerged as important regulatory elem

120 eing inhibited by ruthenium red, isopentenyl pyrophosphate, HC-030031, A967079 or TRPA1 knockout.

121 of the PAg (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBP) as well as their aryloxy diester ph

122 microbial (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) or endogenous pyrophosphates (isop

123 microbial (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by selected pathogens dur

124 substrate, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), is not produced in metazoans, and

125 microbial [(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate, HMBPP] or endogenous (isopentenyl pyropho

126 Pyrophosphate homeostasis is crucial for normal phloem f

127 activity is critical for the maintenance of pyrophosphate homeostasis required for phloem function.

128 een demonstrated to dephosphorylate inositol pyrophosphates; however, theSaccharomyces cerevisiaehomo

129 The UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH is an essential lipid A bio

130 phosphate synthesis from ATP was reduced and pyrophosphate hydrolysis (via TNAP; pyrophosphate -> pho

131 Remarkably, 5' end recognition and pyrophosphate hydrolysis by the PPsome complex also cont

132 the synthesis and reduced the degradation of pyrophosphate in aortas and blood ex vivo, suggesting th

133 acid from l-glutamic acid and dimethylallyl pyrophosphate in red macroalgae and show that the biosyn

134 sfer reactions to form sugar-nucleotides and pyrophosphate in the presence of two Mg(2+) ions (Mg(2+)

135 s products of ATP resulted in a <9% yield of pyrophosphate in wild-type blood and aortas, showing tha

136 ither mevalonate 5-phosphate or mevalonate 5-pyrophosphate, in which a single enzyme carries out two

137 trended to decrease extracellular inorganic pyrophosphate, increase mineralization.

138 trended to decrease extracellular inorganic pyrophosphate, increased mineralization and co-localised

139 quired for C6-C3' bond formation, resembling pyrophosphate initiated class I terpene cyclase reaction

140 ization factor, and an appropriate inorganic pyrophosphate/inorganic phosphate ratio is critical for

141 pathomechanism relating to reduced inorganic pyrophosphate/inorganic phosphate ratio.

142 We show a specific induction of inositol pyrophosphate InsP8 by jasmonate and demonstrate that st

143 incorporations in the presence of inorganic pyrophosphate intended to equilibrate forward (polymeriz

144 way for the conversion of IPAs to isoprenoid pyrophosphate intermediates that enabled the production

145 (polyP into pyrophosphate), ATP sulfurylase (pyrophosphate into ATP), hexokinase (ATP into glucose 6-

146 pyrophosphatase, which hydrolyzes inorganic pyrophosphate into two phosphates.

147 g(2+)-assisted release of the product (i.e., pyrophosphate) into the solution, shedding light on the

148 adds nucleotides to the 3'-end of the RNA, a pyrophosphate ion is generated after each nucleotide inc

149 In the presence of pyrophosphate ions the solubility of FePP strongly incre

150 mation a soluble complex between Fe(III) and pyrophosphate ions, which leads to an 8-10-fold increase

151 ty of FePP as a function of pH and excess of pyrophosphate ions.

152 esponsible for the synthesis of the inositol pyrophosphates IP7 and IP8, reach abnormally high cell d

153 d from the 5-carbon diphosphates isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMA

154 tase domain of Asp1, a bifunctional inositol pyrophosphate (IPP) kinase/pyrophosphatase that intercon

155 ant truncated AaIPPI1 isomerized isopentenyl pyrophosphate (IPP) to dimethyl allyl pyrophosphate (DMA

156 d via sequential condensation of isopentenyl pyrophosphate (IPP) to dimethylallyl pyrophosphate (DMAP

157 a subset of the phosphoantigen {isopentenyl pyrophosphate [IPP] and (E)-4-hydroxy-3-methyl-but-2-eny

158 P) or endogenous pyrophosphates (isopentenyl pyrophosphate [IPP]).

159 phosphate, HMBPP] or endogenous (isopentenyl pyrophosphate, IPP) and PAg sensing depends on the expre

160 is subject to metabolite control by inositol pyrophosphates (IPPs), exerted through the 3'-processing

161 tide determining whether primarily ortho- or pyrophosphate is released.

162 raphosphate dimers in which ATP, rather than pyrophosphate, is the leaving group.

163 In this study, we cloned an isopentenyl pyrophosphate isomerase (IPPI) cDNA, AaIPPI1, from Artem

164 t-2-enyl pyrophosphate (HMBPP) or endogenous pyrophosphates (isopentenyl pyrophosphate [IPP]).

165 cidate how the methylene substitution in the pyrophosphate leaving group affects cognate and non-cogn

166 and associated metal complex and orient the pyrophosphate leaving group for in-line catalysis.

167 imeric dinucleotide (DIAL) that replaces the pyrophosphate leaving group of the native substrate with

168 s-base mechanism, as does protonation of the pyrophosphate leaving group, which is consistent with ge

169 beta and gamma phosphates to help orient the pyrophosphate leaving group.

170 irus injection every 4 weeks restored plasma pyrophosphate levels and, consequently, significantly re

171 6 in the liver for up to 4 weeks, increasing pyrophosphate levels in plasma.

172 e liver and, consequently, reduced inorganic pyrophosphate levels underlie the pathogenesis of PXE.

173 hypothesized that strains with high inositol pyrophosphate levels will have an increased stress respo

174 ABCC6 mutations thus lead to reduced plasma pyrophosphate levels, resulting in the calcification dis

175 These reactions form a pyrophosphate linkage, the stability of which we have ch

176 causes the accumulation of the undecaprenyl pyrophosphate-linked intermediate ECA-lipid II.

177 We show that, under these conditions, pyrophosphate-linked RNA can act as a template for the p

178 ed for activity and that the utility for the pyrophosphate linker may be general for internalizing AD

179 te factor, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate, may increase both the attractiveness of i

180 that IP6K1 and -2 together control inositol pyrophosphate metabolism and thereby physiologically reg

181 ological phosphatase that modulates inositol pyrophosphate metabolism by dephosphorylating the IP7iso

182 lation between absolute quantitative (99m)Tc-pyrophosphate metrics and traditional measures of cardia

183 embrane it increased extracellular inorganic pyrophosphate, mineralization, and ENPP1 activity.

184 Extracellular inorganic pyrophosphate, mineralization, ENPP1 activity expression

185 ons of residues making hydrogen bonds to the pyrophosphate moiety also abrogated TNF-alpha secretion,

186 formation of a cage-like complex between the pyrophosphate moiety of lipid II and the two thioether-b

187 and platinum(IV) complexes coordinated to a pyrophosphate moiety, exhibit excellent antitumor activi

188 Vdelta2 T cells recognize pyrophosphate molecules derived from microbes or tumor c

189 e kinases (IP6Ks) that generate the inositol pyrophosphates, most notably 5-diphosphoinositol pentaki

190 ses and membrane-bound pyrophosphatases make pyrophosphate needed for the synthesis of ATP by an acet

191 ing partners are the C-terminus of LtnA1 and pyrophosphate of lipid II.

192 de) ligand HL with Cu(2+) in the presence of pyrophosphate (P2O7)(4-) affords the complex [LCu(II)2(P

193 Our study links the inositol pyrophosphate pathway to the synthesis of polyphosphate

194 Because the exopolyphosphatase leaves one pyrophosphate per polyphosphate chain, the polyphosphate

195 osphatase family as a physiological inositol pyrophosphate phosphatase.

196 ns have suggested that the reduced inorganic pyrophosphate/phosphate ratio is the cause of soft conne

197 e-(lysyl-Nzeta)-AMP intermediate and release pyrophosphate (PP(i)) or nicotinamide mononucleotide.

198 Biomineralization is regulated by inorganic pyrophosphate (PP(i)), a potent physiological inhibitor

199 t luminal inorganic orthophosphate (P(i)) or pyrophosphate (PP(i)), and neutral or alkaline pH can st

200 re we study the second oxidation step, using pyrophosphate (PP) as a Mn(III) trap.

201 ively uncharacterized member of the inositol pyrophosphate (PP-InsP) signaling family: 1,5-bis-diphos

202 TP levels are a hallmark of altered inositol pyrophosphate (PP-IP) synthesis, and basal ATP levels we

203 SPX domains that are receptors for inositol pyrophosphates (PP-InsP), suggesting that PP-InsPs may r

204 The inositol pyrophosphates (PP-InsPs) are a unique group of intracel

205 Yeast cells unable to synthesize inositol pyrophosphates (PP-InsPs) are unable to induce the ESR.

206 inositol phosphates (InsPs) and myo-inositol pyrophosphates (PP-InsPs) is a daunting challenge due to

207 inositol polyphosphates (InsPs) and inositol pyrophosphates (PP-InsPs).

208 catalyse phosphorylation of IP3 to inositol pyrophosphate, PP-IP5/IP7, which is essential for virule

209 protein have significantly higher levels of pyrophosphate (PPi ) and short-chain polyphosphate (poly

210 concept of proof, the inhibition effects of pyrophosphate (PPi) against the etching of AuNPLs based

211 s have a well-documented role in hydrolyzing pyrophosphate (PPi) and capturing the released energy to

212 phate release with DNA templates showed that pyrophosphate (PPi) dissociation was fast after nucleoti

213 ble nanocomposite probe for the detection of pyrophosphate (PPi) in physiological conditions and in i

214 characterized by reduced levels of inorganic pyrophosphate (PPi) in plasma.

215 Plasma inorganic pyrophosphate (PPi) level was reduced (<30%) in the Abcc

216 er and consequently reduced plasma inorganic pyrophosphate (PPi) levels underlie PXE.

217 gene, resulting in reduced plasma inorganic pyrophosphate (PPi) levels.

218 rtantly, during processive primer extension, pyrophosphate (PPi) release was rate-limiting so that th

219 The approach combines the use of inorganic pyrophosphate (PPi) to control the onset and rate of ena

220 It is thought that the release of pyrophosphate (PPi) triggers reverse conformational chan

221 flux of ATP, which is rapidly converted into pyrophosphate (PPi), a major calcification inhibitor.

222 P, which is rapidly converted into inorganic pyrophosphate (PPi), a potent inhibitor of calcification

223 f extracellular inorganic phosphate (Pi) and pyrophosphate (PPi).

224 decreased concentrations of plasma inorganic pyrophosphate (PPi).

225 Entamoeba histolytica ACK (EhACK) which uses pyrophosphate (PPi)/inorganic phosphate (Pi) (acetyl pho

226 e 3' end of a nascent RNA in the presence of pyrophosphate producing NTP.

227 nucleotide incorporation, Rev1 converts the pyrophosphate product to two monophosphates, which drive

228 An efficient 1-hour technetium-99 m pyrophosphate protocol had comparable diagnostic perform

229 Technetium-99 m pyrophosphate protocols for transthyretin cardiac amyloi

230 NAD(+) is synthesized from 5-phosphoribose-1-pyrophosphate (PRPP), and we found that treating cells f

231 levels of the key metabolite phosphoribosyl pyrophosphate (pRpp), decreasing purine synthesis to fav

232 ole-3,5-dicarboxylic acid and phosphoribosyl pyrophosphate (PRPP).

233 erent approach that uses a novel P(V) pyrene pyrophosphate reagent to generate derivatives that are p

234 d significant decreases in the monoester and pyrophosphate regions, with a corresponding increase in

235 ase that catalyzes the synthesis of inositol pyrophosphate, regulates inositol synthesis in mammalian

236 ile a closed conformation is associated with pyrophosphate release and thioester bond formation.

237 Pyrophosphate release completes the nucleotide addition

238 in single turnover kinetic studies show that pyrophosphate release is faster than the chemistry step,

239 d a mechanism in which the rate constant for pyrophosphate release is slowed for certain misincorpora

240 e has been reported in the open state before pyrophosphate release or in the closed state.

241 surements of the rates of polymerization and pyrophosphate release with DNA templates showed that pyr

242 namically favorable after enzyme opening and pyrophosphate release, and it appears to limit the rate

243 ogical function was previously assumed to be pyrophosphate removal from triphosphorylated transcripts

244 ocessing, 3' adenylation and uridylation, 5' pyrophosphate removal, and, often, U-insertion/deletion

245 egulation of mRNA structure by this inositol pyrophosphate represents an epitranscriptomic control pr

246 e two metabolites, chlorophyllide and phytyl pyrophosphate, required for the final step in chlorophyl

247 in the structure of the eukaryotic thiamine pyrophosphate riboswitch in the context of a hexanucleot

248 well-defined PS repeating unit undecaprenyl pyrophosphate (RU-PP-Und), the key building block in thi

249 omography and such specialized techniques as pyrophosphate scanning.

250 Herein, we adapt a pyrophosphate sensor assay to monitor PBP1b-catalyzed gl

251 thesis is based on the notion that inorganic pyrophosphate serves as a powerful inhibitor of minerali

252 tability and P-body dynamics by the inositol pyrophosphate signaling molecule 5-InsP(7) (5-diphosphoi

253 at can contribute to specificity in inositol pyrophosphate signaling, regulating InsP8 turnover indep

254 e accompanied by the release of undecaprenyl pyrophosphate, solanesyl pyrophosphate (SPP) is used as

255 We studied 72 patients who underwent (99m)Tc-pyrophosphate SPECT/CT using a novel general-purpose cad

256 ase of undecaprenyl pyrophosphate, solanesyl pyrophosphate (SPP) is used as a surrogate to bind a ter

257 oducing all three ent-, (+)- and syn-copalyl pyrophosphate stereoisomers that naturally occur as cent

258 (BTN)3A1 was shown to be required for prenyl pyrophosphate stimulation.

259 A positive Tc-99m pyrophosphate study was defined by the presence of diffu

260 prenylating system that generates isoprenyl pyrophosphate substrates from glucose to prenylate an ar

261 pecificity, but requires expensive isoprenyl pyrophosphate substrates.

262 Inositol pyrophosphates, such as diphospho-myo-inositol pentakisp

263 firmly established cellular target, farnesyl pyrophosphate synthase (FPPS).

264 The human farnesyl pyrophosphate synthase (hFPPS), a key regulatory enzyme

265 allosteric inhibitors of the human farnesyl pyrophosphate synthase (hFPPS), characterized by a chira

266 Undecaprenyl pyrophosphate synthase (UppS) is an essential enzyme in

267 and expressed much lower levels of farnesyl pyrophosphate synthase.

268 Moreover, pyrophosphate synthesis from ATP was reduced and pyropho

269 e toxin specifically modifies phosphoribosyl pyrophosphate synthetase (Prs), an essential enzyme in n

270 pse-specific mutations in the phosphoribosyl pyrophosphate synthetase 1 gene (PRPS1), which encodes a

271 Phosphoribosyl pyrophosphate synthetase-1 (PRPS1) is a key enzyme in nu

272 In single-center studies, technetium 99m pyrophosphate (Tc 99m PYP) cardiac imaging noninvasively

273 Thiamin pyrophosphate (ThDP), the active form of thiamin (vitami

274 ine amperometric biosensor based on thiamine pyrophosphate (ThDP)-dependent transketolase (TK)-cataly

275 be less inhibitory to primer extension than pyrophosphate, the canonical byproduct.

276 in Hyp osteocytes drives the accumulation of pyrophosphate through auto-/paracrine suppression of TNA

277 atalyze the hydrolysis of dUTP into dUMP and pyrophosphate to maintain the proper nucleotide pool for

278 ward reduction by Mn(2+), in the presence of pyrophosphate to trap the Mn(3+) product, was proportion

279 ssays show high-affinity binding of inositol pyrophosphates to the F-box protein COI1-JAZ jasmonate c

280 The reduced production of pyrophosphate, together with the reduction in plasma ATP

281 f consensus on the cooperativity of thiamine pyrophosphate (TPP) binding into the two active sites, i

282 Thiamin pyrophosphate (TPP) is the active form of vitamin B(1) a

283 In the case of the thiamine 5'-pyrophosphate (TPP) riboswitch from the Escherichia coli

284 e (ThiL) catalyzes the last step of thiamine pyrophosphate (TPP) synthesis, the ATP-dependent phospho

285 low), which also binds the cofactor thiamine pyrophosphate (TPP) with an affinity up to two-orders of

286 Thiamine pyrophosphate (TPP)-dependent oxalate oxidoreductase (OO

287 ly to form the final active coenzyme thiamin pyrophosphate (TPP).

288 o synthesis of defective proteins, inorganic pyrophosphate transport, ENPP1 activity and expression o

289 iamin transporters and mitochondrial thiamin pyrophosphate transporter expression levels were suppres

290 min transporter-2, and mitochondrial thiamin pyrophosphate transporter proteins and messenger RNA wer

291 iamin transporters and mitochondrial thiamin pyrophosphate transporter, leading to adenosine triphosp

292 in transporter-2), and mitochondrial thiamin pyrophosphate transporter.

293 eagent type (water, NaNO3, KNO3, tetrasodium pyrophosphate (TSPP), tetramethylammonium hydroxide (TMA

294 generated by dephosphorylating undecaprenyl pyrophosphate (Und-PP).

295 e enzyme responsible for degrading inorganic pyrophosphate, we hypothesized that reducing TNAP levels

296 measured by absolute quantitation of (99m)Tc-pyrophosphate were moderately correlated with LVMI and s

297 decreased when the enzyme solution contained pyrophosphate, which traps the intermediate Mn(III) and

298 1) revealed that it is regulated by inositol pyrophosphates, which can bind to its SPX domain.

299 nt (c-PyPA) obtained from the cyclization of pyrophosphate with a reactive diisopropylaminodichloroph

300 Here, we show that Zn-pyrophosphate (ZnP) nanoparticles loaded with the photos