ライフサイエンスコーパス: pyruvate

1 llowing injection of hyperpolarized [1-(13)C]pyruvate.

2 hich is condensed with another CO(2) to form pyruvate.

3 he time required for H(2)O(2) elimination by pyruvate.

4 nsation of a pathway intermediate (xNA) with pyruvate.

5 n part, linked to a deficient respiration on pyruvate.

6 hile there was no difference in oxidation of pyruvate.

7 , to allow optimal metabolism of lactate and pyruvate.

8 the introduced Asp mimicked the presence of pyruvate.

9 haride components, as well as a reduction in pyruvate.

10 A) cycle by producing acetyl coenzyme A from pyruvate.

11 the metabolism and transport of glucose and pyruvate.

12 viated by oxidizing extracellular lactate to pyruvate.

13 idation reaction the generation of cytosolic pyruvate.

14 ere to monitor the decarboxylation of sodium pyruvate-1,2-[(13)C(2)] at a 15 mM concentration to form

15 With 1,000 uM pyruvate, a concentration that can only exist extracellu

16 We show that pyruvate, a simple organic molecule that can form in hyd

17 atty acids and acyl carnitines and increased pyruvate along with TCA cycle intermediates in females (

18 As pyruvate and acetyl-CoA play central roles in cellular m

19 portion of the TCA cycle while accumulating pyruvate and aspartate that rescue their redox defects.

20 tion of hyperpolarized [1-carbon 13 {(13)C}]-pyruvate and DCE MRI at 3 T at baseline and after one cy

21 We find that pyruvate and DHAP were the metabolites that responded mo

22 ed [5-(13)C]glutamate produced from [2-(13)C]pyruvate and hyperpolarized [1-(13)C]glutamate produced

23 c state of these cells, DNP-MRSI of 1-(13) C-pyruvate and its downstream metabolites, 1-(13) C-lactat

24 Addition of pyruvate and L-lactate (+PL) to RN at 50% of standard co

25 hyperpolarized (13)C label exchange between pyruvate and lactate but not by positron emission tomogr

26 ith elevated (50% control) concentrations of pyruvate and lactate in the first step medium and EAA an

27 atumoral heterogeneity of the hyperpolarized pyruvate and lactate signals were observed.

28 which catalyzes (13)C label exchange between pyruvate and lactate, hypoxia-inducible factor-1 (HIF1al

29 c resonance spectroscopy with hyperpolarized pyruvate and magnetic resonance imaging at rest and duri

30 Instead, the interim glycolytic products (pyruvate and NADH) are held in cytosolic equilibrium wit

31 d respiration rates approximating those with pyruvate and palmitoylcarnitine in WT.

32 hondria with exogenous CoA partially rescued pyruvate and palmitoylcarnitine oxidation capacities, im

33 ibiting MTCH2 in AML cells increased nuclear pyruvate and pyruvate dehydrogenase (PDH), which induced

34 vated brown adipocytes increased labeling of pyruvate and TCA cycle intermediates from U(13)C-glucose

35 el between injected hyperpolarized [1-(13)C]-pyruvate and the endogenous lactate pool was observed, c

36 3)C label exchange between injected [1-(13)C]pyruvate and the endogenous tumor lactate pool.

37 CP4 reveal the genetic relationships between pyruvate and the three major nutrients, and GmPDAT, GmZF

38 esulted in a large increase in intracellular pyruvate and was highly synergistic in decreasing neurob

39 irreversibly converts lactate and oxygen to pyruvate and water.

40 oad substrate specificity toward glyoxylate, pyruvate, and hydroxypyruvate, having the highest cataly

41 three metabolites-indole-3-ethanol, indole-3-pyruvate, and indole-3-aldehyde-which are derived from g

42 oxylates, such as tartrate, malate, lactate, pyruvate, and mandelate, significantly promoted the rate

43 Pyruvate antagonizes the effects of hypoxia on preferent

44 ion methods that premagnetise agents such as pyruvate are currently receiving significant attention b

45 ocks for cell growth and regeneration, using pyruvate as the main substrate.

46 r 11,916 possible routes between glucose and pyruvate at different pre-determined stoichiometric yiel

47 findings strongly suggest the management of pyruvate availability to be a promising strategy to comb

48 work from Sarah's laboratory has shown that pyruvate available in the metastatic niche enables cance

49 e find that inflammatory macrophages reroute pyruvate away from pyruvate dehydrogenase (PDH) in an NO

50 luding sugar transport, aerobic respiration, pyruvate breakdown, and the glyoxylate cycle.

51 rganelle maintenance, but that production of pyruvate by PyrKII is not responsible for this phenomeno

52 fibroblasts, and this flux depended on both pyruvate carboxylase and malic enzyme 1 activity.

53 xidation decreased, whereas rates of hepatic pyruvate carboxylase flux remained unchanged.

54 ic lipolysis, hepatic acetyl-CoA content and pyruvate carboxylase flux, while also increasing mitocho

55 also exhibited increased sensitivity to the pyruvate carboxylase inhibitor phenylacetate.

56 The activity of pyruvate carboxylase, the predominant enzyme for anapler

57 Pancreatic cancer cells exhibited increased pyruvate carboxylation relative to fibroblasts, and this

58 Here, skeletal muscle-specific Mitochondrial Pyruvate Carrier (MPC) deletion in mice diverted pyruvat

59 The mitochondrial pyruvate carrier (MPC) is critical for cellular homeosta

60 54) of the MPC2 subunit of the mitochondrial pyruvate carrier (MPC) is presented.

61 Knockdown of mitochondrial pyruvate carrier (MPC) isoforms or expression of the dom

62 with a potent inhibitor of the mitochondrial pyruvate carrier (UK5099) decreased the NADH/NAD(+) rati

63 Mitochondrial pyruvate carrier 1 (MPC-1) appears to be a tumor suppres

64 pyruvate, which means that the mitochondrial pyruvate carrier MPC is poised to exert ultrasensitive c

65 Targeting the mitochondrial pyruvate carrier promotes alanine oxidation to mitigate

66 aerobic glycolysis by deleting mitochondrial pyruvate carrier recapitulates age-dependent T cell phen

67 demonstrate that the enzymatic depletion of pyruvate coincided with the dispersion of established bi

68 work, we study Mtb metabolism of lactate and pyruvate combining classic microbial physiology with a '

69 lung cancer patients, we find intracellular pyruvate concentrations inversely correlate with histone

70 e activation and significant accumulation of pyruvate, corroborated by increased expression of mitoch

71 olatile biosynthesis, and identified a melon pyruvate decarboxylase, PDC1, that is highly expressed i

72 oA in the TAZ-KO cells to a ~50% decrease in pyruvate dehydrogenase (PDH) activity, which was observe

73 nverting pyruvate to acetyl-CoA (AcCoA), the pyruvate dehydrogenase (PDH) complex (PDC) links glycoly

74 We define a pyruvate dehydrogenase (PDH) dependency in leader cells

75 In four groups of eight Wistar rats, we used pyruvate dehydrogenase (PDH) flux studies to demonstrate

76 atory macrophages reroute pyruvate away from pyruvate dehydrogenase (PDH) in an NO-dependent and hypo

77 DP/ATP carrier protein (AAC) 1 and AAC2, and pyruvate dehydrogenase (PDH) were assessed by respiromet

78 respiration, decreased enzymatic activity of pyruvate dehydrogenase (PDH), and increased production o

79 pyruvate dehydrogenase phosphatase (PDP) and pyruvate dehydrogenase (PDH), dramatically increased PDH

80 in AML cells increased nuclear pyruvate and pyruvate dehydrogenase (PDH), which induced histone acet

81 s through dephosphorylation or activation of pyruvate dehydrogenase (PDH), which mediates opening of

82 PDK-mediated decreases in pyruvate dehydrogenase activity and oxygen consumption r

83 asing hepatic mitochondrial activity through pyruvate dehydrogenase and elevating enterohepatic bile

84 As a result, HAX-1 ablation activates pyruvate dehydrogenase and increases mitochondria utiliz

85 The pyruvate dehydrogenase complex (PDH) critically regulate

86 the metabolic consequence of activating the pyruvate dehydrogenase complex (PDH) to increase pyruvat

87 activated in mouse metastasis models, drives pyruvate dehydrogenase complex (PDHc) activation to main

88 oduction via glucose oxidation by depressing pyruvate dehydrogenase complex activity.

89 Possible interactions between CfrA and the pyruvate dehydrogenase complex or PII protein have been

90 ion of the E1alpha regulatory subunit of the pyruvate dehydrogenase complex, which in turn inhibits f

91 herapeutic levels in the RV, reduced phospho-pyruvate dehydrogenase expression, RV fibrosis, and hype

92 In fed rats, Acipimox decreased pyruvate dehydrogenase flux (to 0.512 +/- 0.13, P = .04)

93 overload caused heart failure with decreased pyruvate dehydrogenase flux and poor ejection fraction r

94 9, P = .002), though this rise did not match pyruvate dehydrogenase flux observed in rats fed carbohy

95 Treatment of endometriosis HPMCs with the pyruvate dehydrogenase kinase (PDK) inhibitor/PDH activa

96 Here, we show that pyruvate dehydrogenase kinase (PDK)-2 plays a role in hy

97 lation governed by at least four isozymes of pyruvate dehydrogenase kinase (PDK).

98 Pyruvate dehydrogenase kinase (PDK)4, a critical regulat

99 athways and dephosphorylates and inactivates pyruvate dehydrogenase kinase 1, Akt, Raf, mitogen-activ

100 A splice site mutation in the canine pyruvate dehydrogenase kinase 4 (PDK4) gene has been sho

101 Knockdown of pyruvate dehydrogenase kinase 4 (PDK4) or inhibition wit

102 Our results show that pyruvate dehydrogenase kinase inhibition improves the co

103 g water containing no supplement or the PDK (pyruvate dehydrogenase kinase) inhibitor dichloroacetate

104 of histone deacetylase, cyclooxygenase, and pyruvate dehydrogenase kinase.

105 e mitochondria by increasing the activity of pyruvate dehydrogenase kinases 1 and 4.

106 proliferation, altered expression levels of pyruvate dehydrogenase phosphatase (PDP) and pyruvate de

107 with suppression of the catalytic subunit of pyruvate dehydrogenase phosphatase 1 this leads to incre

108 eam metabolism of [1-(13)C]pyruvate via PDH (pyruvate dehydrogenase, [(13)C]bicarbonate), lactate deh

109 of multiple key enzyme complexes, including pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenas

110 Pharmacologic inhibitor of pyruvate dehydrogenase, which controls the transition fr

111 Although pyruvate delays cell entry into S phase, pyruvate repres

112 film cells, we furthermore demonstrated that pyruvate depletion resulted in a reduction of biofilm bi

113 ronsted acid multicomponent reaction between pyruvate derivatives, amines, and aldehydes for the prep

114 Additional pyruvate-derived molecules such as acetoin and alanine w

115 Pyruvate dissimilation was shown to depend upon two enzy

116 isation transfer catalyst [Ir(H)(2) (eta(2) -pyruvate)(DMSO)(IMes)].

117 ondrial Ca(2+) controls up to 85% of maximal pyruvate-driven OXPHOS rates, mediated by the activity o

118 ure patients showed elevated CSF lactate and pyruvate during delirium, consistent with acutely altere

119 Here we have characterized cell lactate and pyruvate dynamics using the FRET sensors Laconic and Pyr

120 tion rewired IL-2-induced effects, promoting pyruvate entry into the tricarboxylic acid cycle and inh

121 wo enzymes, pyruvate:formate lyase (PFL) and pyruvate:ferredoxin oxidoreductase (PFOR), that lose act

122 KDM8 associates with PKM2, the gatekeeper of pyruvate flux and translocates PKM2 into the nucleus, wh

123 use of hyperpolarized [1-carbon 13 {(13)C}]-pyruvate for real-time measurement of metabolism and res

124 rt in which photoinduced ET in the RS enzyme pyruvate formate-lyase activating enzyme cleaved the S-C

125 Under anaerobic conditions, pyruvate formate-lyase enabled 2-ketobutyrate biosynthes

126 lation was shown to depend upon two enzymes, pyruvate:formate lyase (PFL) and pyruvate:ferredoxin oxi

127 uired in central metabolism for transporting pyruvate from the cytosol into the mitochondrial matrix.

128 ere constructed, 24 of which are known, e.g. pyruvate-GmPDAT-GmFATA2-oil content.

129 Considering that pyruvate has been previously demonstrated to be required

130 n with strategies that involve disruption of pyruvate homeostasis and indicate possible resistance me

131 An increased extracellular concentration of pyruvate, however, does have remarkable peroxide scaveng

132 strong signals for [1-(13) C]- and [2-(13) C]pyruvate in addition to a long-lived singlet state in th

133 e report evidence that the small fraction of pyruvate in photoreceptors that does get oxidized by the

134 ured mouse astrocytes maintain mitochondrial pyruvate in the low micromolar range, below cytosolic py

135 e same time suppressing further oxidation of pyruvate in the mitochondria by increasing the activity

136 which in turn inhibits further oxidation of pyruvate in the mitochondria-instead, pyruvate is reduce

137 ed or enhanced, respectively, unidirectional pyruvate influxes and [1-(13)C]pyruvate-to-[1-(13)C]lact

138 hibit increased glucose excursions following pyruvate injections, indicating increased gluconeogenesi

139 Pyruvate interacts with the side chain of Lys-43 and wit

140 vate Carrier (MPC) deletion in mice diverted pyruvate into circulating lactate.

141 ic metabolism by inhibiting the transport of pyruvate into the mitochondria, promoting hepatocellular

142 usly, they rewire metabolic routes to import pyruvate into the TCA cycle in an energy substrate speci

143 the cytosolic concentrations of lactate and pyruvate is a direct readout of the balance between glyc

144 ion of pyruvate in the mitochondria-instead, pyruvate is reduced to lactate.

145 ctrometry, we report isotopic resolution for pyruvate kinase (232 kDa) and beta-galactosidase (466 kD

146 divided by CCS fwhm) of ~60 is obtained for pyruvate kinase (MW ~ 233 kDa); however, ion mobility re

147 Pyruvate kinase (PYK) is an essential glycolytic enzyme

148 ntified the protein as a novel crab allergen pyruvate kinase 2.

149 We found increased pyruvate kinase activity and a decreased ratio of reduce

150 1 expression might be responsible for higher pyruvate kinase activity in db/db mouse retina.

151 redictions correctly classify SNP effects in pyruvate kinase and suggest a genetic basis for strain-s

152 f the allosteric regulation of rabbit muscle pyruvate kinase by Ala to demonstrate that this effector

153 Pyruvate kinase deficiency (PKD) is an autosomal-recessi

154 and efficacy of mitapivat in 52 adults with pyruvate kinase deficiency who were not receiving red-ce

155 We found that pyruvate kinase II (PyrKII) is essential for organelle m

156 oral, small-molecule allosteric activator of pyruvate kinase in red cells.

157 s that promote the metabolic activity of the pyruvate kinase isoform PKM2, such as TEPP-46 and DASA-5

158 glycolytic enzymes alpha-enolase (ENO1) and pyruvate kinase isozyme M2 (PKM2), were assessed for the

159 , we identified exosome-mediated transfer of pyruvate kinase M2 (PKM2) from PCa cells into bone marro

160 is mediated by inhibitory S-nitrosylation of pyruvate kinase M2 (PKM2) through a novel locus of regul

161 Moreover, levels of pyruvate kinase M2 (PKM2) were increased in this model a

162 Here, we show that the pyruvate kinase M2 (PKM2), a glycolytic enzyme required

163 ship of TG2 to a terminal glycolytic enzyme, pyruvate kinase M2 (PKM2), and found that PKM2 regulates

164 tic intrabody, intrabody 5 (IB5), recognized pyruvate kinase M2 (PKM2), which is expressed in cancer

165 ic glycolysis and tumor growth by inhibiting pyruvate kinase M2 (PKM2).

166 ng, as a model system, the glycolytic enzyme pyruvate kinase M2 (PKM2).

167 In addition, loss of the glycolytic enzyme pyruvate kinase M2 impairs trabeculation.

168 Very recently, we found that pyruvate kinase M2 isoform (PKM2) regulates visual funct

169 noma (HCC) through nuclear relocalization of pyruvate kinase M2 isoform (PKM2), a key regulator of th

170 ncluding many metabolic proteins such as the pyruvate kinase M2 isoform (PKM2).

171 Tumor pyruvate kinase M2 isoform (tM2-PK), which is an isoform

172 AR (androgen receptor) and PKM2 (pyruvate kinase M2) have key roles in these processes.

173 nometabolism, with increased cytosolic PKM2 (pyruvate kinase M2), phosphorylated PKM2, HIF-1alpha (hy

174 a Warburg effect, including cytosolic PKM2 (pyruvate kinase M2), phosphorylated PKM2, succinate, HIF

175 The glycolytic enzyme Pyruvate Kinase Muscle 2 (PKM2) has described roles in r

176 Pkm2 (Pyruvate kinase muscle isoenzyme 2) is an isoenzyme of t

177 lar to cancer cells, photoreceptors maintain pyruvate kinase muscle isoform 2 (PKM2) expression, whic

178 Pyruvate kinase muscle isoform 2 (PKM2) is a key glycoly

179 Pyruvate kinase muscle isoform 2 (PKM2) is a key glycoly

180 ic reprogramming and IFN-gamma secretion via pyruvate kinase muscle isozyme 2 (PKM2) to accelerate at

181 ncreased expression of the glycolytic enzyme pyruvate kinase muscle isozyme M2 and after KIR cross-li

182 tation and were associated with the red-cell pyruvate kinase protein level at baseline.

183 NA ends, 2-phospho-L-lactate is a product of pyruvate kinase side reaction, and both potently inhibit

184 e, glyceraldehyde-3-phosphate dehydrogenase, pyruvate kinase, and glucose-6-phosphate isomerase showe

185 example, hexokinase-2, phosphofructokinase, pyruvate kinase, and lactate dehydrogenase), while at th

186 two host glycolytic enzymes, aldolase A and pyruvate kinase, as well as lactate dehydrogenase, are e

187 activities, decreased lactate dehydrogenase, pyruvate kinase, creatine kinase, and cytochrome c oxida

188 rt of a larger complex of proteins including pyruvate kinase.

189 2) is an isoenzyme of the glycolytic enzyme pyruvate kinase.

190 ting concentrations of hexose monophosphate, pyruvate, lactate, alanine, glycerol-3 phosphate, and is

191 ed markers of PTR and G6PD deficiency (e.g., pyruvate/lactate ratios), along with potential compensat

192 ory data, including increased lactate and/or pyruvate levels (7/7), and imaging findings (7/7), inclu

193 pressure (IOP)-dependent decline in retinal pyruvate levels coupled to dysregulated glucose metaboli

194 of P. aeruginosa biofilms, we asked whether pyruvate likewise contributes to the maintenance of the

195 (5 T2DM, 5 control), hyperpolarized [1-(13)C]pyruvate magnetic resonance spectra were also acquired a

196 Hyperpolarized [1-(13)C]pyruvate magnetic resonance spectroscopic imaging (MRSI)

197 level using in vivo hyperpolarized [1-(13)C] pyruvate magnetic resonance spectroscopy (MRS).

198 Mito(4)-ATO and Mito(10)-ATO inhibit both pyruvate/malate-dependent complex I and duroquinol-depen

199 the induced transmembrane influx of [1-(13)C]pyruvate mediated by MCT1.

200 ited by the transmembrane influx of [1-(13)C]pyruvate mediated predominately by monocarboxylate trans

201 te impaired insulin sensitivity and enhanced pyruvate-mediated gluconeogenesis.

202 stress, we investigated the in-vivo cardiac pyruvate metabolism and contractility in a porcine model

203 ession of MPC-1 stimulated the mitochondrial pyruvate metabolism and inhibited glycolysis, while MPC-

204 sionHyperpolarized carbon 13 measurements of pyruvate metabolism can provide rapid feedback for monit

205 gest that the pneumococcus can alter flux of pyruvate metabolism dependent on the carbohydrate presen

206 Imaging of hyperpolarized [1-(13)C]pyruvate metabolism in breast cancer is feasible and dem

207 MRI measurement of hyperpolarized [1-(13)C]pyruvate metabolism is therefore a more sensitive marker

208 f MRI measurement of hyperpolarized [1-(13)C]pyruvate metabolism versus PET measurement of (18)F-FDG

209 In galactose, pyruvate metabolism was shunted toward acetyl-CoA produc

210 nduced changes in central energy metabolism, pyruvate metabolism, and oxidative stress correlate with

211 of MPC-1 and KDM5A on PDA and mitochondrial pyruvate metabolism, and the mechanism underling reduced

212 ng several processes and pathways, including Pyruvate Metabolism, Tricarboxylic acid (TCA) cycle, and

213 associated with various processes, including pyruvate metabolism, unfolded protein response, oxidativ

214 n, and stemness via inhibiting mitochondrial pyruvate metabolism.

215 findings demonstrate hyperpolarized ([1-13C])pyruvate MRI as a tool for accurately assessing the clin

216 merging clinical applications of HP [1-(13)C]pyruvate MRI will be highlighted.

217 Thus, hyperpolarized [1-(13)C]pyruvate MRSI measures primarily MCT1-mediated [1-(13)C]

218 Thus, hyperpolarized [1-(13)C]pyruvate MRSI provides a noninvasive functional assessme

219 This inhibitory effect of pyruvate on cell growth is primarily attributed to its f

220 venous injection of hyperpolarized [1-(13)C]-pyruvate on mice with orthotopic U87MG glioma and health

221 -detectable glutamate production from either pyruvate or alpha-ketoglutarate as potential translatabl

222 Blocking mitochondrial pyruvate or fatty acid flux was linked to increased auto

223 HD neurons could be rescued with addition of pyruvate or late glycolytic metabolites, but not earlier

224 by supplementation with the energy substrate pyruvate or oleate.

225 monocytic cells cultured in the presence of pyruvate or the mitochondrial reactive oxygen species sc

226 We conclude that intracellular pyruvate, or other alpha-ketoacids, whose endogenous con

227 glycolytic enzyme in the phosphoenolpyruvate-pyruvate-oxaloacetate node that is a central switch poin

228 The pyruvate oxidase (SpxB)-dependent production of H(2)O(2)

229 or dichloroacetate, a compound that promotes pyruvate oxidation and generation of mitochondrial acety

230 vate dehydrogenase complex (PDH) to increase pyruvate oxidation at the expense of fermentation.

231 Fatty acid and pyruvate oxidation capacities were 40-60% lower in Taz(K

232 of glycolysis without subsequent increase in pyruvate oxidation through the tricarboxylic acid cycle.

233 rease in Acsl1(M) (-/-) skeletal muscle, and pyruvate oxidation was similar in gastrocnemius homogena

234 sponse that prevents excessive mitochondrial pyruvate oxidation when glycolysis is sustained after a

235 ls were fed dichloroacetate, an activator of pyruvate oxidation.

236 vitro activities of carbonic anhydrase (CA), pyruvate, phosphate dikinase (PPDK), ribulose-1,5-bispho

237 abolism (increased glucose, lactate, lactate/pyruvate ratio (LPR), glutamate; decreased glycerol) and

238 l load, the metformin effects on the lactate/pyruvate ratio and glucose production are explained by a

239 ed a metformin-induced rise in blood lactate:pyruvate ratio and improved NADH:NAD(+) balance in the h

240 mitochondria, resulting in a raised lactate/pyruvate ratio and redox-dependent inhibition of glucone

241 The (13)C-labeled lactate-to-pyruvate ratio derived from hyperpolarized (13)C MRI and

242 over time and was found suitable for lactate/pyruvate ratio detection in biological samples.

243 use as a binding moiety to develop a lactate/pyruvate ratio FRET-based genetically encoded indicator,

244 oaches do not allow detection of the lactate/pyruvate ratio in a single readout with high spatial/tem

245 esigned to quantitatively assess the lactate/pyruvate ratio in intact mammalian cells.

246 4% reduction in the (13)C-labeled lactate-to-pyruvate ratio resulted in correct identification of the

247 ected LOXCAT lowered the circulating lactate:pyruvate ratio, blunted a metformin-induced rise in bloo

248 rt chain decreased the extracellular lactate:pyruvate ratio, normalized the intracellular NADH:NAD(+)

249 ormis is an endogenous sensor of the lactate/pyruvate ratio, suitable for use as a binding moiety to

250 ear equilibrium with the circulating lactate:pyruvate ratio, we hypothesized that reductive stress co

251 al NADH/NAD state and an increase in lactate/pyruvate ratio, whereas a higher metformin dose (>=5 nmo

252 layed the highest similarity to the hydroxyl pyruvate reductase isoform 2 in Arabidopsis thaliana Enz

253 e structural features of this plant hydroxyl pyruvate reductase.

254 ive reductive amination but instead promoted pyruvate reduction to lactate, and ferric hydroxides did

255 ugh pyruvate delays cell entry into S phase, pyruvate represses histone gene expression independent o

256 of the biofilm structure, with depletion of pyruvate resulting in dispersion.

257 e exchange (SABRE) can provide strong (13) C pyruvate signal enhancements in seconds through the form

258 The lactate-to-pyruvate signal ratio (LAC/PYR) ranged from 0.021 to 0.4

259 al supplementation of the glycolytic product pyruvate strongly protected from neurodegeneration in bo

260 metabolites relating to glycolysis (lactate, pyruvate, succinate).

261 ns in glucose metabolism including increased pyruvate, suggesting that modulating glycolysis may be n

262 OXPHOS to workload by adjusting the rate of pyruvate supply from the cytosol to the mitochondria.

263 lly Glyco(Hi) mitochondria exhibit augmented pyruvate-supported respiration relative to fatty acids.

264 abolic network involving serine, alanine and pyruvate that drives the endogenous synthesis and accumu

265 form of PKM2 converts phosphoenolpyruvate to pyruvate, the dimeric form of PKM2 has alternative, nong

266 pathway for acetate production derived from pyruvate, the end product of glycolysis.

267 that the conversion of hyperpolarized (13)C-pyruvate to (13)C-lactate during the one-minute measurem

268 Conversion from pyruvate to acetate is activated under hypoxic condition

269 By converting pyruvate to acetyl-CoA (AcCoA), the pyruvate dehydrogena

270 ows only a small fraction of glucose-derived pyruvate to enter mitochondria.

271 detect the associated increase in flux from pyruvate to lactate catalyzed by lactate dehydrogenase u

272 preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is associa

273 olic imaging of labeled carbon transfer from pyruvate to lactate to detect early response and FOXM1-m

274 ydrogenase (LDH) catalyzes the conversion of pyruvate to lactate, with concomitant oxidation of reduc

275 lactate dehydrogenase A (LDHA) that converts pyruvate to lactate.

276 erceivers had a more efficient conversion of pyruvate to lactate.

277 est that glycerol is a better substrate than pyruvate to test in vivo production of glucose in fastin

278 tumors that initial hyperpolarized [1-(13)C]pyruvate-to-[1-(13)C]lactate conversion rates as well as

279 s attribute elevated hyperpolarized [1-(13)C]pyruvate-to-[1-(13)C]lactate conversion rates in aggress

280 nidirectional pyruvate influxes and [1-(13)C]pyruvate-to-[1-(13)C]lactate conversion rates, independe

281 umor models in vivo, hyperpolarized [1-(13)C]pyruvate-to-[1-(13)C]lactate conversion was highly depen

282 These mice also exhibit impaired glucose and pyruvate tolerance, but normal insulin sensitivity.

283 SI measures primarily MCT1-mediated [1-(13)C]pyruvate transmembrane influx in vivo, not glycolytic fl

284 ith obeticholic acid increased mitochondrial pyruvate transport and reduced insulin-induced lipogenes

285 me subcellular quantitation of mitochondrial pyruvate transport, concentration and flux.

286 Inhibition of glycolysis, mitochondrial pyruvate transport, or mitochondrial fatty acid transpor

287 we show that the reaction of glyoxylate with pyruvate under mild aqueous conditions produces a series

288 ed 2-methylquinolines with diacetyl or ethyl pyruvate, under environmentally friendly conditions.

289 are correlated with decreased mitochondrial pyruvate uptake and increased glycolysis in HCCs and poo

290 We show that mitochondrial pyruvate uptake is essential for optimal thermogenesis,

291 Mechanistically, pyruvate uptake through Mct2 supported mTORC1 signaling

292 t the potential utility of modulating muscle pyruvate utilization to ameliorate obesity and type 2 di

293 Downstream metabolism of [1-(13)C]pyruvate via PDH (pyruvate dehydrogenase, [(13)C]bicarbo

294 After 21 h, [1-(14)C]C16:0 or [2-(14)C]pyruvate was added to measure complete and incomplete ox

295 sensitivity of the indicator to lactate and pyruvate was characterized through changes in the fluore

296 In glucose, pyruvate was metabolized primarily by LDH to generate la

297 hydrates that feed into glycolysis ending in pyruvate, which is catabolized by several enzymes.

298 in the low micromolar range, below cytosolic pyruvate, which means that the mitochondrial pyruvate ca

299 anol and the nonoxidative decarboxylation of pyruvate, with acetaldehyde being the common intermediat

300 ogical purpose of PFL and PFOR is to degrade pyruvate without disrupting the redox balance, and they