ライフサイエンスコーパス: pyruvate dehydrogenase complex

1 in kinase that regulates the activity of the pyruvate dehydrogenase complex.

2 edium, likely because of the activity of the pyruvate dehydrogenase complex.

3 of the lipoyl-bearing subunit (E(2)) of the pyruvate dehydrogenase complex.

4 gluconeogenic substrates by inactivating the pyruvate dehydrogenase complex.

5 sion of pyruvate to acetyl-coenzyme A by the pyruvate dehydrogenase complex.

6 ld-type kinase toward the protein substrate, pyruvate dehydrogenase complex.

7 kinase 1 (PDK1) on Thr346 to inactivate the pyruvate dehydrogenase complex.

8 lipoamide dehydrogenase associated with the pyruvate dehydrogenase complex.

9 PDH2, which encodes a subunit of the plastid pyruvate dehydrogenase complex.

10 itochondrial enzyme complexes, including the pyruvate dehydrogenase complex.

11 and activates the E1 component of the large pyruvate dehydrogenase complex.

12 at may catalyze the dephosphorylation of the pyruvate dehydrogenase complex.

13 nt, uncompetitive inhibitor of the bacterial pyruvate dehydrogenase complex.

14 ologic phenotypes, or PDHX, a subunit of the pyruvate dehydrogenase complex.

15 the tricarboxylic acid (TCA) cycle enzymes, pyruvate dehydrogenase complex, 2-oxoglutarate dehydroge

16 decreases occurred in the activities of the pyruvate dehydrogenase complex (-41%), isocitrate dehydr

17 ia, in the absence (control) and presence of pyruvate dehydrogenase complex activation by dichloroace

18 No increase in pyruvate dehydrogenase complex activation or acetyl grou

19 Dichloroacetate increased resting pyruvate dehydrogenase complex activation, acetyl-CoA an

20 enhancing mitochondrial protein kinase B and pyruvate dehydrogenase complex activities.

21 At baseline, IMTG, muscle pyruvate dehydrogenase complex activity and the protein

22 Greater pyruvate dehydrogenase complex activity caused a stimula

23 Thus, pyruvate dehydrogenase complex activity is increased by

24 et-induced obese mice significantly augments pyruvate dehydrogenase complex activity with reduced pho

25 oduction via glucose oxidation by depressing pyruvate dehydrogenase complex activity.

26 yruvate dehydrogenase kinases (PDK) inhibits pyruvate dehydrogenase complex activity.

27 45 and 392 on PDHK2 and results in increased pyruvate dehydrogenase complex activity.

28 The assembled core structure of mammalian pyruvate dehydrogenase complex also includes the dihydro

29 es were tested by ELISA for E2 components of pyruvate dehydrogenase complex and 2-oxoglutarate dehydr

30 or entry points to oxidative metabolism (eg, pyruvate dehydrogenase complex and Acyl-CoA dehydrogenas

31 ulation to lactylate PDHA1 lysine 336 in the pyruvate dehydrogenase complex and carnitine palmitoyltr

32 ferase (tE2) of the Saccharomyces cerevisiae pyruvate dehydrogenase complex and complexes of the tE2

33 Activities of the pyruvate dehydrogenase complex and E3 from patient were

34 phosphate (HEThDP) with the Escherichia coli pyruvate dehydrogenase complex and its E1 subunit (PDHc-

35 on of its use in miniaturized assays for the pyruvate dehydrogenase complex and its kinase.

36 rifies the essential nature of the plastidic pyruvate dehydrogenase complex and its role in embryo fo

37 rogenase complex family, which also includes pyruvate dehydrogenase complex and oxoglutarate dehydrog

38 similar to what we recently discovered with pyruvate dehydrogenase complex and oxoglutarate dehydrog

39 utomers coexist on the E1 component of human pyruvate dehydrogenase complex and pyruvate oxidase.

40 ase-specific loss of immune tolerance to the pyruvate dehydrogenase complex and subsequent developmen

41 rotein complexes identified in our analysis, pyruvate dehydrogenase complex and succinate dehydrogena

42 e of oxythiamine, which can inhibit both the pyruvate dehydrogenase complex and transketolase, result

43 was determined by measuring the activity of pyruvate dehydrogenase complex, and cellular metabolic s

44 LUT4, hexokinase II, the E1 component of the pyruvate dehydrogenase complex, and subunits of all four

45 erase (LipB), respectively, to lipoylate apo-pyruvate dehydrogenase complex (apo-PDC).

46 l analysis showing that the lipoyl moiety of pyruvate dehydrogenase complex appears to be involved in

47 uced protein sequences for E3BP of the human pyruvate dehydrogenase complex are reported here.

48 and kinetic parameters as determined by the pyruvate dehydrogenase complex assay; (ii) in thermostab

49 However, a pyruvate dehydrogenase complex assembled in vitro with c

50 of the E1 component of the Escherichia coli pyruvate dehydrogenase complex become organized only on

51 enase kinase (PDK) inhibit the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the

52 enzyme form the structural core of the human pyruvate dehydrogenase complex by providing the binding

53 ively regulate activity of the mitochondrial pyruvate dehydrogenase complex by reversible phosphoryla

54 cetyltransferase (E2) component of mammalian pyruvate dehydrogenase complex can form a 60-mer via ass

55 The pyruvate dehydrogenase complex catalyzes the conversion

56 e that loss of PDHK4, a key regulator of the pyruvate dehydrogenase complex, caused a profound cell g

57 ites of the E1 (EC 1.2.4.1) component of the pyruvate dehydrogenase complex communicate over a distan

58 Both pyruvate-formate lyase and the pyruvate dehydrogenase complex contributed to acetyl-coe

59 Glucose oxidation via pyruvate dehydrogenase complex did not compensate for re

60 s (R1-2) as containing the E2 subunit of the pyruvate dehydrogenase complex, dihydrolipoamide acetylt

61 e two active centers of the Escherichia coli pyruvate dehydrogenase complex E1 component provides a s

62 (ThDP) binding site of the Escherichia coli pyruvate dehydrogenase complex E1 subunit (PDHc-E1), and

63 een in the structure of the Escherichia coli pyruvate dehydrogenase complex E1 subunit (PDHc-E1), mas

64 ar, arsenite treatment destabilizes both the pyruvate dehydrogenase complex E1 subunit and several RN

65 hondrial matrix-located citrate synthase and pyruvate dehydrogenase complex E1alpha-subunit polypepti

66 y biliary cirrhosis (PBC) is the presence of pyruvate dehydrogenase complex E2 subunit (PDC-E2) antim

67 e S-acetyltransferase subunit of the plastid pyruvate dehydrogenase complex (E2) was isolated from a

68 lecule in BEC, we examined the expression of pyruvate dehydrogenase complex-E2 (PDC-E2) messenger RNA

69 fferential expression of glycolysis, plastid pyruvate dehydrogenase complex, fatty acid, and lipid sy

70 nzyme in plastids to catalyze lipoylation of pyruvate dehydrogenase complex for de novo fatty acid sy

71 The PKCdelta/retinol complex signaled the pyruvate dehydrogenase complex for enhanced flux of pyru

72 lpd and odp (encode enzymes involved in the pyruvate dehydrogenase complex formation).

73 acetyltransferase (E2) catalytic core of the pyruvate dehydrogenase complex from Bacillus stearotherm

74 Most bacterial pyruvate dehydrogenase complexes from either gram-positi

75 The activity of the pyruvate dehydrogenase complex has long been determined

76 nase (PDH), the first component of the human pyruvate dehydrogenase complex, has two isoenzymes, soma

77 ity between the lipoyl domains (LD) of human pyruvate dehydrogenase complex (hPDC-E2) and Escherichia

78 s (HiBECs) translocate the E2 subunit of the pyruvate dehydrogenase complex immunologically intact in

79 f pdhD, putatively encoding a subunit of the pyruvate dehydrogenase complex, impairs survival of both

80 ute to the tissue-specific regulation of the pyruvate dehydrogenase complex in normal and pathophysio

81 Regulation of the activity of the pyruvate dehydrogenase complex in skeletal muscle plays

82 cataplerosis) and decreased flux through the pyruvate dehydrogenase complex in the cortex.

83 without increased glucose oxidation through pyruvate dehydrogenase complex in the energy-poor, hyper

84 complex that spontaneously reconstituted the pyruvate dehydrogenase complex in the presence of native

85 hyperphosphorylation and inactivation of the pyruvate dehydrogenase complex in these metabolic condit

86 ly resembles that of the lipoyl domains from pyruvate dehydrogenase complexes, in accord with the exi

87 cid oxidation in avian cells, via effects on pyruvate-dehydrogenase complexes, indicating a role in m

88 ainst a complex set of proteins, among which pyruvate dehydrogenase complex is considered the main au

89 Activity of the mammalian pyruvate dehydrogenase complex is regulated by phosphory

90 component of this entire class of bacterial pyruvate dehydrogenase complexes is responsible for bind

91 rase), the E2 component of the mitochondrial pyruvate dehydrogenase complex, is a novel metabolic lon

92 yl transacetylase (DLAT), independent of the pyruvate dehydrogenase complex, is pivotal in promoting

93 E1 (pyruvate dehydrogenase) component of the pyruvate dehydrogenase complex, it has not proved possib

94 ensional reconstruction of the bovine kidney pyruvate dehydrogenase complex (M(r) approximately 7.8 x

95 t indicates that inhibition of the bacterial pyruvate dehydrogenase complex may represent a promising

96 The pyruvate dehydrogenase complex (mPDC) from potato (Solan

97 f light on the activity of the mitochondrial pyruvate dehydrogenase complex (mt-PDC) by using intact

98 E1 component (pyruvate decarboxylase) of the pyruvate dehydrogenase complex of Bacillus stearothermop

99 poyl acetyltransferase (E2) component of the pyruvate dehydrogenase complex of Bacillus stearothermop

100 drolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes.

101 Possible interactions between CfrA and the pyruvate dehydrogenase complex or PII protein have been

102 ct of its activity, the inactive form of the pyruvate dehydrogenase complex (P-Pdc), both of which ar

103 mportance of muscle pyruvate availability to pyruvate dehydrogenase complex (PDC) activation during i

104 increasing CHO oxidation in vivo, using the pyruvate dehydrogenase complex (PDC) activator, dichloro

105 uscle protein: DNA ratio, a 56% reduction in pyruvate dehydrogenase complex (PDC) activity (P < 0.05)

106 By increasing muscle pyruvate dehydrogenase complex (PDC) activity and acetyl

107 Here we show that inhibition of pyruvate dehydrogenase complex (PDC) activity contribute

108 ion status of glycogen phosphorylase and the pyruvate dehydrogenase complex (PDC) and on the accumula

109 or dephosphorylation and reactivation of the pyruvate dehydrogenase complex (PDC) and, by this means,

110 w that all the subunits of the mitochondrial pyruvate dehydrogenase complex (PDC) are also present an

111 Autoantibodies to the pyruvate dehydrogenase complex (PDC) are present in the

112 and, in particular, the E2 component of the pyruvate dehydrogenase complex (PDC) are the target of a

113 yl-CoA acetyltransferase 1 (ACAT1) regulates pyruvate dehydrogenase complex (PDC) by acetylating pyru

114 The pyruvate dehydrogenase complex (PDC) catalyzes the conve

115 The pyruvate dehydrogenase complex (PDC) catalyzes the conve

116 The human pyruvate dehydrogenase complex (PDC) comprises four mult

117 cetyltransferase (E2) component of mammalian pyruvate dehydrogenase complex (PDC) consists of 60 COOH

118 oantibodies to the assumed major autoantigen pyruvate dehydrogenase complex (PDC) dihydrolipoamide ac

119 The pyruvate dehydrogenase complex (PDC) has a pivotal role

120 oyl transacetylase (DLAT), the E2-subunit of pyruvate dehydrogenase complex (PDC) in a subset of grou

121 ogenase (PDH) and consequently inhibition of pyruvate dehydrogenase complex (PDC) in cancer cells.

122 structural diversity of the E2 component of pyruvate dehydrogenase complex (PDC) in normal and disea

123 at ethylene triggers the accumulation of the pyruvate dehydrogenase complex (PDC) in the nucleus to s

124 any putative (causative) association between pyruvate dehydrogenase complex (PDC) inhibition and lact

125 The human pyruvate dehydrogenase complex (PDC) is a 9.5-megadalton

126 The pyruvate dehydrogenase complex (PDC) is a critical mitoc

127 Mammalian pyruvate dehydrogenase complex (PDC) is a key multi-enzy

128 The pyruvate dehydrogenase complex (PDC) is a multienzyme as

129 Mitochondrial pyruvate dehydrogenase complex (PDC) is crucial for gluc

130 The mitochondrial pyruvate dehydrogenase complex (PDC) is down-regulated b

131 Human pyruvate dehydrogenase complex (PDC) is down-regulated b

132 The pyruvate dehydrogenase complex (PDC) is inactivated in m

133 Pyruvate dehydrogenase complex (PDC) is one of the large

134 Activity of the mammalian pyruvate dehydrogenase complex (PDC) is regulated by pho

135 The human pyruvate dehydrogenase complex (PDC) is regulated by rev

136 The pyruvate dehydrogenase complex (PDC) is subjected to mul

137 The pyruvate dehydrogenase complex (PDC) is the primary meta

138 cterized by serum autoantibodies against the pyruvate dehydrogenase complex (PDC) located in the inne

139 e carbohydrate reserves, the reaction of the pyruvate dehydrogenase complex (PDC) must be down-regula

140 poyl domain, p45, has been identified in the pyruvate dehydrogenase complex (PDC) of the adult parasi

141 The mitochondrial pyruvate dehydrogenase complex (PDC) plays a crucial rol

142 ion in adjusting the activation state of the pyruvate dehydrogenase complex (PDC) through determining

143 ogenase kinase (PDHK) is an integral part of pyruvate dehydrogenase complex (PDC) to which it is anch

144 rase (E2) subunit of the maize mitochondrial pyruvate dehydrogenase complex (PDC) was postulated to c

145 wing 2-oxo acid dehydrogenase complexes: the pyruvate dehydrogenase complex (PDC), the branched chain

146 pyruvate dehydrogenase (E1) in the mammalian pyruvate dehydrogenase complex (PDC), whose activity is

147 High-fat feeding inhibits pyruvate dehydrogenase complex (PDC)-controlled carbohyd

148 ized that PDK4 up-regulation, which inhibits pyruvate dehydrogenase complex (PDC)-dependent carbohydr

149 immunized rabbits develop high-titer Abs to pyruvate dehydrogenase complex (PDC)-E2, the major autoa

150 sis is breakdown of T-cell self-tolerance to pyruvate dehydrogenase complex (PDC).

151 E2 components of the purified KDC and (0)the pyruvate dehydrogenase complex (PDC).

152 breakdown of normal immune self tolerance to pyruvate dehydrogenase complex (PDC).

153 ional states of the Saccharomyces cerevisiae pyruvate dehydrogenase complex (PDC).

154 yzes phosphorylation and inactivation of the pyruvate dehydrogenase complex (PDC).

155 regulator of flux through the mitochondrial pyruvate dehydrogenase complex (PDC).

156 esponses to a highly conserved self-antigen, pyruvate dehydrogenase complex (PDC).

157 lipogenesis controlled by the mitochondrial pyruvate dehydrogenase complex (PDC).

158 on through pharmacological activation of the pyruvate dehydrogenase complex (PDC).

159 etyl-CoA in mitochondria is catalyzed by the pyruvate dehydrogenase complex (PDC).

160 activates mitochondrial PDH and consequently pyruvate dehydrogenase complex (PDC).

161 gh the phosphorylation and inhibition of the pyruvate dehydrogenase complex (PDC).

162 AT5A bound the E1beta and E2 subunits of the pyruvate dehydrogenase complex (PDC).

163 oligodeoxynucleotides (ODN) on responses to pyruvate dehydrogenase complex (PDC, the autoantigen in

164 49 (92%), with specificity directed against pyruvate dehydrogenase complex (PDC-E2) alone in 22 of 4

165 poylated enzymes such as the E2 component of pyruvate dehydrogenase complex (PDC-E2) are targets for

166 they were specifically directed against the pyruvate dehydrogenase complex (PDC-E2) in 15 of 19 pati

167 The E2 component of mitochondrial pyruvate dehydrogenase complex (PDC-E2) is the immunodom

168 The E2 subunit of pyruvate dehydrogenase complex (PDC-E2) is the major aut

169 hondrial response to the E2 component of the pyruvate dehydrogenase complex (PDC-E2), has unique feat

170 e acetyltransferase, the E2 component of the pyruvate dehydrogenase complex (PDC-E2), is the autoanti

171 cognized by AMA are the E2 components of the pyruvate dehydrogenase complex (PDC-E2), the branched ch

172 oantigens including the E2 components of the pyruvate dehydrogenase complex (PDC-E2), the branched-ch

173 ecular mimicry between the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2), the major mitoc

174 In this study, we produced recombinant pyruvate dehydrogenase complex (PDC-E2)-specific dimeric

175 s have homology with the E2 component of the pyruvate dehydrogenase complex (PDC-E2).

176 is directed against the E2 component of the pyruvate dehydrogenase complex (PDC-E2).

177 ondrial autoantigen, the E2 component of the pyruvate dehydrogenase complex (PDC-E2).

178 (AMAs), directed to the E2 component of the pyruvate dehydrogenase complex (PDC-E2).

179 ic autoantibodies to the E2 component of the pyruvate dehydrogenase complex (PDC-E2).

180 ry biliary cirrhosis (PBC), E2 components of pyruvate dehydrogenase complexes (PDC-E2), has a lipoate

181 , amino acids 159 to 167 on E2 components of pyruvate dehydrogenase complexes (PDC-E2), the major mit

182 peptides encoded by the E2 components of the pyruvate dehydrogenase complexes (PDC-E2).

183 e, amino acid 159-167 of the E2 component of pyruvate dehydrogenase complexes (PDC-E2).

184 nodominant mitochondrial autoantigen of PBC (pyruvate dehydrogenase complex [PDC-E2]) was addressed.

185 The pyruvate dehydrogenase complexes (PDCs) from all known l

186 The pyruvate dehydrogenase complex (PDH) critically regulate

187 The pyruvate dehydrogenase complex (PDH) has been hypothesiz

188 the metabolic consequence of activating the pyruvate dehydrogenase complex (PDH) to increase pyruvat

189 as a cellular lipoamidase that regulates the pyruvate dehydrogenase complex (PDH).

190 xidative decarboxylation of pyruvate via the pyruvate dehydrogenase complex (PDH).

191 activated in mouse metastasis models, drives pyruvate dehydrogenase complex (PDHc) activation to main

192 Dichloroacetate (DCA) stimulates pyruvate dehydrogenase complex (PDHC) activity and lower

193 Pyruvate dehydrogenase complex (PDHC) and oxoglutarate d

194 In Escherichia coli, the pyruvate dehydrogenase complex (PDHC) and pyruvate forma

195 The Escherichia coli pyruvate dehydrogenase complex (PDHc) catalyzing convers

196 etrospective study on X-linked PDHA1-related pyruvate dehydrogenase complex (PDHc) deficiency combine

197 ing to its destabilization and disruption of pyruvate dehydrogenase complex (PDHc) integrity.

198 cherichia coli and report that disruption of pyruvate dehydrogenase complex (PDHc), which converts py

199 tabolic fuel selection as a component of the pyruvate dehydrogenase complex (PDHc).

200 f oxidative phosphorylation by targeting the pyruvate dehydrogenase complex (PDHC).

201 oxylase variant, or to the E1 subunit of the pyruvate dehydrogenase complex (PDHc-E1) from Escherichi

202 nd on the E1 subunit of the Escherichia coli pyruvate dehydrogenase complex (PDHc-E1).

203 fpr promoter region as the E1 subunit of the pyruvate dehydrogenase complex (PDHE1), a central enzyme

204 drogenase kinase 4 (PDK4) is upregulated and pyruvate dehydrogenase complex phosphorylation is increa

205 s to be a common feature in the phylogeny of pyruvate dehydrogenase complexes, protein dynamics is an

206 The highest correlation was with pyruvate dehydrogenase complex (r = 0.77, r2= 0.59).

207 e acetyltransferase (tE(2)) component of the pyruvate dehydrogenase complex reveal an extraordinary e

208 he E3-binding domain (E3BD) of the mammalian pyruvate dehydrogenase complex show that hSBDb has an ar

209 ese novel genetic interactions involving the pyruvate dehydrogenase complex suggested a new role for

210 mitochondrial antibodies that react with the pyruvate dehydrogenase complex, targeting the inner lipo

211 boxylate pyruvate: the E1 component of human pyruvate dehydrogenase complex, the E1 subunit of Escher

212 e investigated whether the E2 subunit of the pyruvate dehydrogenase complex, the E2 subunit of the br

213 chondrial protein kinase that phosphorylates pyruvate dehydrogenase complex, thereby down-regulating

214 dehydrogenase kinase 2 (PDHK2) inhibits the pyruvate dehydrogenase complex, thereby regulating entry

215 umor activity is its ability to activate the pyruvate dehydrogenase complex through inhibition of pyr

216 ch that down-regulates activity of the human pyruvate dehydrogenase complex through reversible phosph

217 t binding of the lipoyl domain 2 (L2) of the pyruvate dehydrogenase complex to PDK3 induces a "cross-

218 n exposure of LThDP to the E1 subunit of the pyruvate dehydrogenase complex was 0.4 s(-1), still more

219 The pyruvate dehydrogenase complex was considerably more act

220 KGDH enzymatic activity, whereas the related pyruvate dehydrogenase complex was unmodified by TFEC an

221 CCase subunits; (2) four subunits to plastid pyruvate dehydrogenase complex were 25% to 70% down-regu

222 stearothermophilus and Enterococcus faecalis pyruvate dehydrogenase complexes were determined and rev

223 g protein, inactivated kinase-depleted maize pyruvate dehydrogenase complex when incubated with MgATP

224 apicoplast LipDH is an integral part of the pyruvate dehydrogenase complex which occurs only in the

225 ion of the E1alpha regulatory subunit of the pyruvate dehydrogenase complex, which in turn inhibits f

226 ion that was required to elicit a 50% active pyruvate dehydrogenase complex, which indicates a marked

227 complex, the E1 subunit of Escherichia coli pyruvate dehydrogenase complex, yeast pyruvate decarboxy