ライフサイエンスコーパス: pyruvate oxidase

1 the oxidation of pyruvate in the presence of pyruvate oxidase.

2 of human pyruvate dehydrogenase complex and pyruvate oxidase.

3 pyruvate oxidase, and the acetate-producing pyruvate oxidase.

4 nase, further suggesting that spxB encodes a pyruvate oxidase.

5 n-biotin recognition with glucose oxidase or pyruvate oxidase.

6 Increased pyruvate oxidase activity alters colony shape by mediati

7 and R6 is associated with increased cellular pyruvate oxidase activity relative to the ancestral stra

8 aled that the cidC mutant produced decreased pyruvate oxidase activity relative to the parental and c

9 t a pleiotropic phenotype, including reduced pyruvate oxidase activity; reduced growth rate; and hype

10 ral model was generated based on homology to pyruvate oxidase and an imidazolinone inhibitor was posi

11 ecarboxylase, the acetyl phosphate-producing pyruvate oxidase, and the acetate-producing pyruvate oxi

12 ldehyde lyase, benzoylformate decarboxylase, pyruvate oxidase, and the E1 component of the human pyru

13 approach to identify spxB, the gene encoding pyruvate oxidase, as the mutated locus in R36A and R6 th

14 A crystal structure of this intermediate in pyruvate oxidase at 1.1 A resolution now challenges this

15 hese responses, as both catalase-treated and pyruvate oxidase-deficient bacteria lacked these activit

16 gordonii release DNA in a process induced by pyruvate oxidase-dependent production of hydrogen peroxi

17 etermined that pneumolysin and streptococcal pyruvate oxidase-derived H2O2 production were required f

18 ed) and the decarboxylation of L-pyruvate by pyruvate oxidase (EC 1.2.3.3).

19 nd confirm the classification of MenD in the pyruvate oxidase family of ThDP-dependent enzymes.

20 titutions to methionine (the residue used in pyruvate oxidase for this purpose) or leucine (the corre

21 e complex, yeast pyruvate decarboxylase, and pyruvate oxidase from Lactobacillus plantarum.

22 n of other enzymes in this family, including pyruvate oxidase, glyoxylate carboligase, pyruvate decar

23 spxB-encoded pyruvate oxidase is a major virulence factor of Streptoc

24 nine and employs alanine transaminase (ALT), pyruvate oxidase (POx), and horseradish peroxidase (HRP)

25 PDHc) and its E1 (ThDP-dependent) component, pyruvate oxidase (POX, phosphorylating; from Lactobacill

26 nes encoding lactate dehydrogenase (ldh) and pyruvate oxidase (poxB) were deleted to block the synthe

27 n the C-terminal segment of Escherichia coli pyruvate oxidase (PoxB), a lipid-activated homotetrameri

28 significant decrease in the protein level of pyruvate oxidase(PoxL), an enzyme required for the gener

29 ve decarboxylation of pyruvate, catalyzed by pyruvate oxidase (PyOd), in the presence of Pi, oxygen,

30 Hydrogen peroxide generated by pyruvate oxidase reacts with nonfluorescent Amplex Red a

31 acteristic slow rate of FAD reduction by the pyruvate oxidase side reaction of the enzyme.

32 hydrogen peroxide (HO) that is dependent on pyruvate oxidase (Spx) activity.

33 ed by the pneumococcus through the action of pyruvate oxidase (SpxB) under conditions of aerobic grow

34 i grown anaerobically or genetically lacking pyruvate oxidase (SpxB) were not bactericidal, nor were

35 binding protein A (CbpA), pneumolysin (Pln), pyruvate oxidase (SpxB), autolysin (LytA), pneumococcal

36 In the present study, pyruvate oxidase (SpxB), the enzyme responsible for endo

37 t-independent fashion and that Streptococcus pyruvate oxidase (SpxB), which enables synthesis of H2O2

38 The pyruvate oxidase (SpxB)-dependent production of H(2)O(2)

39 rved attributes from its predicted ancestor, pyruvate oxidase, such as a ubiquinone-binding site and

40 idC gene product suggested that it encodes a pyruvate oxidase that catalyses the oxidative decarboxyl

41 encodes a member of the family of bacterial pyruvate oxidases which decarboxylates pyruvate to acety

42 tion, we observed that a mutant deficient in pyruvate oxidase, which converts pyruvate to acetyl-phos

43 s of AcP and hydrogen peroxide (H(2)O(2)) by pyruvate oxidase, which is encoded by spxB.