ライフサイエンスコーパス: quadruplex

1 ic metallohelices with human telomeric RNA G-quadruplex.

2 proton T(1) values for a water-soluble DNA G-quadruplex.

3 al spectra for several proteins and an RNA G-quadruplex.

4 folding and unfolding rates in nucleic acid quadruplexes.

5 le exons that contain splice site-proximal G-quadruplexes.

6 le secondary structures such as hairpins and quadruplexes.

7 o switch between inter- and intramolecular G-quadruplexes.

8 metabolites and functionality of the bound G-quadruplexes.

9 ve largely been considered distinct types of quadruplexes.

10 through RNA secondary structures known as G-Quadruplexes.

11 ns do not preferentially interact with DNA G-quadruplexes.

12 pical B-form DNA to single-stranded DNA to G-quadruplexes.

13 ned to two stacked parallel and antiparallel quadruplexes.

14 ion of, and replication through, telomeric G-quadruplexes.

15 is a 31-nt DNA aptamer, consisting of the G-quadruplex and a duplex domain, which is able to effecti

16 On the basis of predicting a stable G-quadruplex and a secondary structure, we truncated 19 nu

17 omains are also essential for remodeling RNA quadruplex and duplex structures.

18 tructure-forming sequences, exemplified by G quadruplex and H-DNA motifs, across the genome in both a

19 d RGG box-dependent binding to the SC1 RNA G-Quadruplex and is required for outgrowth of neurites.

20 specificity is increased by targeting both G-quadruplex and its flanking duplex DNA in a naturally oc

21 ctures of (i) Pseudorabies virus (PRV) RNA G-quadruplex and ligand complex, (ii) PRV DNA G-quadruplex

22 rs by modifying their sequences upon their G-quadruplex and secondary structures.

23 ith a high affinity to human telomeric RNA G-quadruplex and that their binding selectivity considerab

24 The modified 40-nt aptamer, with a stable G-quadruplex and two modified loops, exhibited a 100 times

25 G-rich G-quadruplexes and C-rich i-motifs are the most well-chara

26 ntial to form secondary structures such as G-quadruplexes and i-motifs, respectively.

27 cells, proved to be able to stabilize both G-quadruplexes and R loops and showed a potent cell killin

28 GG domain of FMRP as important for binding G-quadruplexes and the transport of G-quadruplex-containin

29 method in different structural contexts of G-quadruplexes and their complexes.

30 ce of EXO1, forks accumulate at stabilized G-quadruplexes and ultimately collapse.

31 uadruplex and ligand complex, (ii) PRV DNA G-quadruplex, and (iii) an i-motif of human telomeric sequ

32 isomers of [Ru(bqp)(2)](2+) with i-motif, G-quadruplex, and double-stranded DNA.

33 ive DNA structures, like Z DNA, triplexes, G quadruplexes, and I motifs.

34 hysical barriers such as structured genes, G-quadruplexes, and other obstacles.

35 any conformational form of human telomeric G-quadruplex (antiparallel, hybrid, parallel monomers or a

36 assay for HBeAg, which takes advantage of G-quadruplex aptamers for enhanced binding and stability.

37 ng interactions, double-helical stems, and G-quadruplexes are immediately obvious.

38 G-Quadruplexes are noncanonical four-stranded DNA secondar

39 Because of their high stability, RNA G-quadruplexes are proposed to exist in vivo and are sugge

40 Together, these findings position G-quadruplexes as a primary candidate for the NONO-recruit

41 ied translational inhibitory elements with G-quadruplexes as marks for mRNA decay in P-bodies.

42 The quadruplex assay was evaluated with characterized contro

43 Guanine-quadruplex (G-quadruplex) assemblies provide a useful platform for stu

44 cephaeline for investigating mechanisms of G-quadruplex-associated alternative splicing.

45 e-wide role in MiDAS at loci prone to form G-quadruplex-associated R-loops, in a process that is depe

46 o guanine electron donors into crystalline G-quadruplex-based organic frameworks, wherein the electro

47 romising and desirable features to develop G-quadruplex binders as safe and effective anticancer agen

48 In the search for new drug-like selective G-quadruplex binders, a bioinspired design focused on the

49 Searching for potent and selective G-quadruplex binders, here we describe a small series of n

50 We find that the DSM not only functions as a quadruplex binding adaptor but also promotes the remodel

51 ries finds that the Timeless protein has a G-quadruplex binding domain that works together with the D

52 distinct from those regulated by the guanine-quadruplex binding Lia3 protein.

53 To investigate the G-quadruplex binding properties of the new molecules, in v

54 ve Au-carbene affinity and specificity for G-quadruplex binding.

55 sensitive to the well-known intracellular G-quadruplex-binding ligand 360A.

56 9CI that selectively recognizes c-MYC Pu22 G-quadruplex both in vitro and ex vivo.

57 cal property of individual human telomeric G-quadruplexes bound to telomestatin, using optical tweeze

58 olve DNA synthesis: DNA replication across G-quadruplexes; break-induced replication; and processing

59 mers or a 48 nt sequence with two contiguous quadruplexes), but did not avidly interact with duplex D

60 ands have been reported that bind to dimeric quadruplexes, but their preclinical pharmacological eval

61 can dramatically simplify the depiction of G-quadruplexes by automatically detecting G-tetrads and tr

62 Although G-quadruplexes can be found throughout the genome, telomer

63 ssays, we show for the first time that these quadruplexes cannot be analyzed independently, but they

64 With 9CI and c-MYC Pu22 G-quadruplex complex as the fluorescent response core, a D

65 affinity to the immobilized aptamer, the MB/quadruplex complex broke and MB washed away from the apt

66 ltered mechanical anisotropy of the ligand-G-quadruplex complex can add additional level of regulatio

67 amer as the photo-probe, generating the MB/G-quadruplex complex.

68 rvation that NONO preferentially binds the G-quadruplex conformation of G-rich C9orf72 repeat RNA, we

69 rather folds into a compact stacked three-G-quadruplex conformation.

70 es key insight into rate-limiting steps of G-quadruplex conformational dynamics.

71 d ribosomes still promoted localization of G-quadruplex-containing messages.

72 inding G-quadruplexes and the transport of G-quadruplex-containing transcripts.

73 adjacent to the complex at the 5' end of the quadruplex core.

74 G-quadruplexes, resulting in inhibition of G-quadruplex-dependent alternative splicing.

75 y chemical compounds capable of regulating G-quadruplex-dependent alternative splicing.

76 and that it regulates gene expression in a G-quadruplex-dependent fashion.

77 G-quadruplex motifs, and treatment with a G-quadruplex-disrupting small molecule causing dissociatio

78 selectivity, and induced the formation of G-quadruplex DNA along with the related DNA damage respons

79 moter activity of c-MYC gene that contains G-quadruplex DNA forming sequence in the upstream promoter

80 op a competitive screening method in which G-quadruplex DNA linked magnetic nanoparticles pull down s

81 We also found that TraB binds G-quadruplex DNA structures with higher affinity than TraB

82 rapeutic potential of PARP1 inhibition via G-quadruplex DNA targeting.

83 g during unwinding, but not the binding of G quadruplex DNA.

84 th the stem-loop structure in RNA and with G quadruplex DNA.

85 mass spectrometry analysis of proteins and G-quadruplex DNA.

86 Targeting G-quadruplex DNAs for cancer treatment is a very promising

87 When replication forks encounter G-quadruplexes, EXO1 resects the nascent DNA proximal to t

88 tic and biochemical analyses show that RNA G-quadruplex folding is able to regulate translation and m

89 NA, or beta-l-RNA series exhibit unchanged G-quadruplex folding topology.

90 te that the binding between the ligand and G-quadruplex follows the induced-fit model.

91 family of drugs targeting the MYC promoter G-quadruplex for MYC suppression.

92 approach allows separation of K(+)-induced G-quadruplex formation and subsequent refolding and provid

93 stabilization of RNA sequences capable of G-quadruplex formation by metallohelices investigated in t

94 and rice, providing direct evidence of RNA G-quadruplex formation in living eukaryotic cells.

95 there is a lack of direct evidence for RNA G-quadruplex formation in living eukaryotic cells.

96 n GTEx, suggesting that variants affecting G-quadruplex formation within UTRs may also contribute to

97 The G-quadruplex formed in the proximal promoter region of the

98 ibe not only the basic structural motif of G-quadruplexes formed by, e.g., telomeric DNA sequences, b

99 dihydroguanine ((oxo)G), and evaluated the G-quadruplex forming ability of such oligonucleotides.

100 vely edited (pan-edited) transcripts contain quadruplex forming guanine stretches, which must be remo

101 The structure of the 68 nt sequence with G-quadruplex forming potential within the hTERT promoter i

102 confirmed their binding to pseudoknot and G-quadruplex forming RNAs as well as their ability to regu

103 A single G-quadruplex forming sequence from the human telomere can

104 ic and genomic data, we show that putative G-quadruplex forming sequences (pG4) in 5' and 3' UTRs are

105 Potential G-quadruplex forming sequences (PQSs) in promoters have a

106 ghout the genome are enriched in potential G-quadruplex-forming DNA sequences.

107 an in vitro assay, we show that a putative G-quadruplex-forming sequence (PQFS) in the first intron o

108 -rich promoter element that is a potential G-quadruplex-forming sequence (PQS) in NEIL3 is a site for

109 However, we identified a specific G-quadruplex-forming sequence at the heavy-strand promoter

110 xperiments have identified a non-canonical G-quadruplex-forming sequence containing bulges within the

111 porphyrin dyes are first attached to short G-quadruplex-forming sequences and then reacted with per-O

112 tiple sequence alignments, we observe that G-quadruplex-forming sequences are a general feature of LS

113 Such a mechanism enables G-quadruplex-forming sequences to act as long-range sensor

114 oying both telomeric and oncogene promoter G-quadruplex-forming sequences.

115 romoter G-quadruplex motifs, which did adopt quadruplex forms in solution.

116 Inspired by the hydrogen-bonded G-quadruplexes found frequently in guanine-rich DNA, here

117 d that VEZF1 binds directly with DNA guanine quadruplex (G quadruplex, G4) structures in vitro and in

118 icing enhancer motifs and a propensity for G-quadruplex (G-Q) formation, linking the defective splici

119 Guanine-quadruplex (G-quadruplex) assemblies provide a useful pl

120 We find that PARP3 regulates G quadruplex (G4) DNA in response to DNA damage, which sup

121 viously showed that CST binds and disrupts G-quadruplex (G4) DNA in vitro, suggesting that CST may pr

122 eplication stress and DNA damage by way of G-quadruplex (G4) DNA secondary structure.

123 A guanine quadruplex (G4) DNA structure and a cis-acting sRNA (G4-

124 Here, we map differentially enriched G-quadruplex (G4) DNA structure-forming regions (DeltaG4Rs

125 G-quadruplex (G4) DNA structures can form physical barrier

126 Formation of G-quadruplex (G4) DNA structures in key regulatory regions

127 The polymorphic nature of G-quadruplex (G4) DNA structures points to a range of pote

128 g domain that exhibits specific binding to G-quadruplex (G4) DNA structures.

129 structural transition of the sequence to a G-quadruplex (G4) fold that positions the AP in a loop fac

130 oxidation sensitivity and a propensity for G-quadruplex (G4) folding, both of which depend upon seque

131 G-quadruplex (G4) is a noncanonical secondary structure of

132 Here, we examined the contribution of G-quadruplex (G4) nucleic acid structures to AID targeting

133 G-quadruplex (G4) sequences are abundant in untranslated r

134 Importantly, G-quadruplex (G4) stabilizing compounds induce chromosome

135 G-Quadruplex (G4) structures are four-stranded noncanonica

136 Four-stranded G-quadruplex (G4) structures form through self-recognition

137 ensity to adopt four-stranded tetrahelical G-quadruplex (G4) structures that are overrepresented in g

138 (G), but G-rich DNA can form four-stranded G-quadruplex (G4) structures, which plays important roles

139 ring of sites with a high propensity to form quadruplex (G4) structures.

140 ces that have been previously annotated as G-quadruplex (G4) structures.

141 e capability of assembling into tetrameric G-quadruplex (G4) structures.

142 ce potentially able to form three adjacent G-quadruplex (G4) units, namely, K2, SP, and K1.

143 G-quadruplex (G4)-containing substrates mimicking the mamm

144 DNA sequences can fold into four-stranded G-quadruplex (G4-DNA) structures.

145 G-quadruplexes (G4) are alternative nucleic acid structure

146 G-quadruplexes (G4) are noncanonical secondary structures

147 Guanine-rich oligonucleotides can form G-quadruplexes (G4), which are stabilized by the hydrogen

148 peated Element (OGRE), potentially forming G-quadruplexes (G4).

149 an adopt non-canonical structures known as G-quadruplexes (G4).

150 sual three-dimensional structures known as G-quadruplexes (G4).

151 inds directly with DNA guanine quadruplex (G quadruplex, G4) structures in vitro and in cells, which

152 Noncanonical tetrahelical nucleic acids, G-quadruplexes (G4Q), and i-motifs have been shown to play

153 G quadruplexes (G4s) and R loops are noncanonical DNA stru

154 Guanine-quadruplexes (G4s) are non-canonical four-stranded struc

155 RNA G-quadruplexes (G4s) are secondary structures proposed to

156 G-quadruplexes (G4s) are stable secondary structures that

157 Genomic maps of DNA G-quadruplexes (G4s) can help elucidate the roles that the

158 The G-quadruplexes (G4s) formed in PDGFR-beta gene promoter ar

159 The study of G-quadruplexes (G4s) in a cellular context has demonstrate

160 The in vitro formation of stable G-quadruplexes (G4s) in human rRNA was recently reported.

161 first fluorescent probe designed to detect G-quadruplexes (G4s) in vivo.

162 ow exists to support that formation of DNA G-quadruplexes (G4s) is coupled to altered gene expression

163 terparts form parallel and/or antiparallel G-quadruplexes (G4s).

164 We found that an RNA G-quadruplex (GQ) forms in SHR mRNA and is capable of trig

165 G-quadruplex (GQ) stabilizing small molecule (SM) ligands

166 ich telomere DNA repeats readily fold into G-quadruplex (GQ) structures in vitro, and the presence of

167 ences in the formation of non-Watson-Crick G-quadruplex (GQ) structures.

168 biophysical characterization of folding of G-Quadruplex (GQ)-based light-up aptamers such as Spinach,

169 G-quadruplexes (GQs) can adopt diverse structures and are

170 G-quadruplexes (GQs) formed from four consecutive repeats

171 s, we have identified a number of putative G-quadruplexes (GQs) forming sequences.

172 G-Quadruplexes (GQs) serve as popular recognition elements

173 n fold into noncanonical structures called G-quadruplexes (GQs), which exhibit a common stem structur

174 RNA G-quadruplexes have been suggested to play key roles in fu

175 To our knowledge, G-quadruplexes have not been reported previously in riboso

176 assembled nucleobases, such as G-quartets or quadruplexes, have numerous applications, but light-resp

177 ence thermal and biological stabilities of G-quadruplex in a position-dependent manner.

178 anthrene, dppz=dipyridophenazine) bind DNA G-quadruplex in an enantiospecific manner that parallels t

179 stable species (parallel and antiparallel G-quadruplex in K+ and Na+, respectively).

180 probes selectively targeting the specific G-quadruplex in the mimics.

181 Our study reveals the existence of RNA G-quadruplex in vivo and indicates that RNA G-quadruplex s

182 ligands that specifically target promoter G-quadruplexes in cancer cells.

183 try to identify proteins that bind to rRNA G-quadruplexes in cell lysates.

184 To modulate biological functions, G-quadruplexes in genome are often non-specifically target

185 on and immune evasion through formation of G-quadruplexes in its mRNA.

186 ed immune recognition through formation of G-quadruplexes in LANA mRNA.

187 for further investigation into the role of G-quadruplexes in paraspeckle formation and function.

188 tiple conformations coexisting for dimeric G-quadruplexes in solution.

189 We propose the stability of G-quadruplexes in the mtDNA control region, influencing th

190 10 tandem G-tracts that form highly stable G-quadruplexes in vitro.

191 to form complex RNA structures termed RNA G-quadruplexes in vitro.

192 icational or co-transcriptional folding of G-quadruplex inside the polymerase machinery in cells.

193 The binding isotherm for the POT1-quadruplex interaction was sigmoidal, indicative of a co

194 ligands and then used with a new series of G-quadruplex interactive bis-triazolyl ligands that are sy

195 se gamma DNA synthesis is reduced after this quadruplex is exposed to UV in vitro.

196 he complex folding energy landscape of DNA G-quadruplexes leads to numerous conformations for this fu

197 Here, we demonstrate that the G-quadruplex ligand 20A causes growth arrest of cancer cel

198 basis for the retention of potency by this G-quadruplex ligand has been examined using whole transcri

199 g agents, and that the cytotoxicity of the G-quadruplex ligand pyridostatin involves trapping topoiso

200 d the identification of a highly selective G-quadruplex ligand that, when studied in human cancer cel

201 A recently developed small-molecule G-quadruplex ligand, the trisubstituted naphthalene diimid

202 of the first dual BCL2/c-MYC gene promoter G-quadruplex ligand.

203 ing strategy is first optimized with known G-quadruplex ligands and then used with a new series of G-

204 G-quadruplex ligands exert their antiproliferative effects

205 pecific duplex-binding molecules with potent quadruplex ligands.

206 As that have structured 5' UTRs (including G-quadruplexes), many of which are involved in signal tran

207 s such as gold (Au)-carbene that stabilize G-quadruplexes may also interfere with the elongation of t

208 of G-rich C9orf72 repeat RNA, we find that G-quadruplex motifs are abundant and conserved features of

209 ural specificity and provide evidence that G-quadruplex motifs mediate NONO-NEAT1 association, with N

210 ng sites on NEAT1 corresponding largely to G-quadruplex motifs, and treatment with a G-quadruplex-dis

211 lidated TRF2 occupancy at several promoter G-quadruplex motifs, which did adopt quadruplex forms in s

212 on binding as a doublet to one side of the G-quadruplex, much larger translational and orientational

213 nd, BMPQ-1, which bound to human telomeric G-quadruplex multimers over monomeric G-quadruplexes with

214 ses occurring at specific locations within G-quadruplex nucleic acids, providing valuable probes for

215 le rearrangements seen between RNA and DNA G-quadruplexes of the same sequence.

216 uiting the BLM helicase, which can resolve G-quadruplexes on the lagging-strand template.

217 al features of the experimentally observed G-quadruplexes (OQs), highlighting differences in their pr

218 r the work was limited to the colorimetric G-quadruplex or fluorescent substrate cleaving NAzymes.

219 RNA, double-helical DNA, Pauling triplex, G-quadruplex, or DNA structures 'decorated' with proteins.

220 s introduced in differentiating multimeric G-quadruplexes over monomeric species, which would be able

221 grooves of the Oxytricha nova's telomeres' G-quadruplex ( Oxy-GQ), in agreement with high-resolution

222 imilar size have the capability of binding G-quadruplexes, potentially affecting the expression of th

223 gest that genetic variation is enriched in G-quadruplex regions that impede mitochondrial DNA replica

224 G-quadruplexes represent unique roadblocks to DNA replicat

225 ally in syn or anti in nonsubstituted hTel G-quadruplex requires a minor structural rearrangement or

226 aeline as small molecules that disrupt RNA G-quadruplexes, resulting in inhibition of G-quadruplex-de

227 copy reveals that excitation of TDI in the G-quadruplex results in symmetry-breaking charge separatio

228 eveals different binding landscapes of RNA G-quadruplex (rG4) structures-binding proteins and discove

229 G-quadruplex RNA evicts the PRC2 catalytic core from the s

230 Preferential binding of G-quadruplex RNA is conserved, surprisingly using differen

231 three-layered intramolecular (3+1) hybrid G-quadruplex scaffold, in which three strands are oriented

232 ss this question, we studied two different G-quadruplexes, selecting a single conformation by blockin

233 ables the identification of c-MYC and BCL2 G-quadruplex selective bis-triazole ligands that specifica

234 these transcripts contain an enrichment of G-quadruplex sequences in their 3' UTRs, suggesting that F

235 differentiates many widely accepted putative quadruplex sequences that do not actually form stable ge

236 Herein, we employ an improved version of a G-quadruplex sequencing method (G4-seq) to generate whole

237 results are supportive of the concept that G-quadruplex small molecules such as CM03 have potential f

238 We used G-quadruplex-stabilizing ligand to define the inhibition i

239 orted by treatment of cells with TMPyP4, a G-quadruplex-stabilizing ligand.

240 CCAGGCTGCAA), that self-associates to form a quadruplex structure containing two central antiparallel

241 associated with increased formation of the G-quadruplex structure during DNA replication.

242 A guanine-deficit G-quadruplex structure formation by a sequence containing

243 Here we report the G-quadruplex structure formed by a 23-nucleotide G-rich se

244 nding of POT1 to an initially folded 24 nt G-quadruplex structure is four orders of magnitude slower.

245 Here, a (4n - 1) G-quadruplex structure is shown to be capable of binding g

246 self-assembles into a nearly monodisperse G-quadruplex structure of 16 layers, with strong pai-overl

247 n FMRP binds with a high affinity to an RNAG-quadruplex structure that lacks single-stranded loops, d

248 ing capability caused by (oxo)G, a loss of G-quadruplex structure was observed for most oligonucleoti

249 ve chemical targeting of the non-canonical G-quadruplex structure within the PARP1 promoter, which co

250 wo complexes, both comprised of a (4n - 1) G-quadruplex structure, one bound to a linear dinucleotide

251 moter folds into a stacked, three-parallel G-quadruplex structure.

252 gands with high selectivity for a specific G-quadruplex structure.

253 telomeric sequence by stabilizing the RNA G-quadruplex structure.

254 equence content or the formation of an RNA G-quadruplex structure.

255 bility and secondary structures, including G-quadruplex structures (G4s).

256 -quadruplex in vivo and indicates that RNA G-quadruplex structures act as important regulators of pla

257 es of a lead which was proved to stabilize G-quadruplex structures and increase R loop levels in huma

258 HX36 has been linked to cellular RNA and DNA quadruplex structures and to AU-rich RNA elements.

259 In vitro, DHX36 remodels DNA and RNA quadruplex structures and unwinds DNA duplexes in an ATP

260 Most importantly, these G-quadruplex structures are still stable at physiological

261 ofiling, we determine that hundreds of RNA G-quadruplex structures are strongly folded in both Arabid

262 Here we used DNA G-quadruplex structures as model systems to demonstrate th

263 a DEAH-box helicase that resolves parallel G-quadruplex structures formed in DNA and RNA.

264 Targeting G-quadruplex structures is currently viewed as a promising

265 on of Telomeres 1) unfolds human telomeric G-quadruplex structures is not fully understood.

266 so promotes the remodeling of RNA duplex and quadruplex structures.

267 NA (pre-mRNA), especially within predicted G-quadruplex structures.

268 ly unwinding RNA:DNA hybrids and resolving G-quadruplex structures.

269 s are capable of binding to RNA containing G-quadruplex structures.

270 dly interact with duplex DNA or with other G-quadruplex structures.

271 telomeres requires the disruption of these G-quadruplex structures.

272 remodeling of inter- and intramolecular RNA quadruplex structures.

273 nd more salt-dependent binding than to the G-quadruplex surface.

274 a single Au-carbene binding at the second G-quadruplex surface.

275 ey also demonstrated a strong and specific G-quadruplex targeting strategy by conjugating highly spec

276 elective artificial nucleases that degrade G-quadruplex telomeric DNA and exhibit selective DNA bindi

277 ng affinity and cleavage reactivity toward G-quadruplex telomeric DNA over duplex DNA.

278 LOTUS domains exhibit high affinity to RNA G-quadruplex tertiary structures implicated in diverse cel

279 irpin (HP) probes, molecular beacons, and G- quadruplex) that mediate cyclic cascade and role of help

280 pull down selective ligands for a particular quadruplex topology from a series of small molecules.

281 the conformational ensemble of multimeric G-quadruplexes towards (3+1) hybrid-2 topology, which beca

282 The mechanisms by which G-quadruplexes transition from one folded conformation to

283 at includes equilibrium constants for both G-quadruplex unfolding and POT1 binding to the resultant s

284 udies showed that POT1 binding is coupled to quadruplex unfolding, with a final complex with a stoich

285 y, which became more pronounced as further G-quadruplex units are added.

286 4 domains have been studied mainly as single quadruplex units derived from short truncated sequences

287 es a structure with three stacked parallel G-quadruplex units, while another features an unusual dupl

288 enous ribonucleoprotein A1 (hnRNP A1) as a G-quadruplex-unwinding helicase, which unfolds these stabl

289 ut dislocates and weakens the loops in the G-quadruplex upon ligand binding.

290 We show that stabilization of G-quadruplexes using small molecules destabilizes the i-mo

291 dentified lead compound exhibits significant quadruplex versus duplex DNA selectivity and suppresses

292 eta gene promoter sequence forms a vacancy G-quadruplex (vG4) which can be filled in and stabilized b

293 lecular mechanism of Au-carbene binding to G-quadruplexes, we employed molecular dynamics simulations

294 much emphasis has been recently given to DNA quadruplexes, we focused here on three-way DNA junctions

295 rad planes changes the conformation of the G-quadruplex, which resembles a balloon squeezed in certai

296 We recently showed that RNA G-quadruplexes, which serve as cis-elements to recruit spl

297 owever, the design of probes recognizing a G-quadruplex with high selectivity in vitro and in vivo re

298 eric G-quadruplex multimers over monomeric G-quadruplexes with high selectivity, and induced the form

299 ermore, we determine that NONO binds NEAT1 G-quadruplexes with structural specificity and provide evi

300 We find a global enrichment of RNA G-quadruplexes with two G-quartets whereby the folding pot