ライフサイエンスコーパス: quadruplex DNA

1 mass spectrometry analysis of proteins and G-quadruplex DNA.

2 platinum(II) complex has good affinity for G-quadruplex DNA.

3 ing class of anticancer agents that target G-quadruplex DNA.

4 nteractions between TOTA and duplex DNA or G-quadruplex DNA.

5 aluate the binding of TMPyP4 and Se2SAP to G-quadruplex DNA.

6 ased selectivity of Tel01 interaction with G-quadruplex DNA.

7 es in their ability to efficiently disrupt G-quadruplex DNA.

8 ity of the perylene-EDTA*metal complex for G-quadruplex DNA.

9 probes have been synthesized and targeted to quadruplex DNA.

10 that are potent and selective ligands for G-quadruplex DNA.

11 complexation of TMPyP4 with human telomeric quadruplex DNA.

12 the presence of 6SG blocks the formation of quadruplex DNA.

13 photo-oxidize guanine in double-stranded and quadruplex DNA.

14 during unfolding of intramolecular parallel quadruplex DNA.

15 g during unwinding, but not the binding of G quadruplex DNA.

16 with correct linkage chemistry relative to G-quadruplex DNA.

17 regulation via removal of damaged bases from quadruplex DNA.

18 th the stem-loop structure in RNA and with G quadruplex DNA.

19 lymerase REV1 are defective in replicating G-quadruplex DNA.

20 eously binds TERRA and telomeric duplex or G-quadruplex DNA.

21 on at increasing excess over human telomeric quadruplex DNA.

22 l molecules that selectively interact with G-quadruplex DNA.

23 ty in both the Na(+) and K(+) forms of the G-quadruplex DNA.

24 c metal ion binding to DNA, particularly for quadruplex DNA.

25 molecules that bind to different features of quadruplex DNA.

26 or nucleic acids and specific preference for quadruplex DNAs.

27 the manganese in the narrow grooves of these quadruplex DNAs.

28 conformational dynamics of 6mG residues in G-quadruplex DNAs.

29 mpounds with selectivity for human telomeric quadruplex DNAs.

30 oth unwind a variety of different forms of G-quadruplex DNA, a structure that can form at guanine-ric

31 selectivity, and induced the formation of G-quadruplex DNA along with the related DNA damage respons

32 at ligands imparted higher stabilization for quadruplex DNA (an increase in the T(m) of up to 21 degr

33 of up to 21 degrees C for human telomeric G-quadruplex DNA and >25 degrees C for promoter G-quadrupl

34 stoichiometry was more complex for telomeric quadruplex DNA and a double-stranded DNA control.

35 in the level of binding of the helicase to G-quadruplex DNA and a reduction in the degree to which th

36 ublished model for PIPER bound to the same G-quadruplex DNA and failed to provide a structural basis

37 methyl-4-pyridyl)porphyrin (TMPyP4) binds to quadruplex DNA and is thereby an inhibitor of human telo

38 ase activity by stabilization of telomeric G-quadruplex DNA and point to a polymerase arrest assay as

39 cation as a probe for interactions between G-quadruplex DNA and potential anticancer therapeutical bi

40 t only mNeil3 had excision activity on Tg in quadruplex DNA and that the glycosylase exhibited a stro

41 ive agents (QIAs) that stabilize telomeric G-quadruplex DNA and thereby inhibit human telomerase; 50%

42 CG)n repeats which can, respectively, form G-quadruplex DNA and Z-DNA.

43 here are many different folding patterns for quadruplex DNAs and the loops exhibit much more variatio

44 ple of an engineered protein that binds to G-quadruplex DNA, and represents a new type of binding int

45 d using thrombin aptamer (TBA), one of the G-quadruplex DNA aptamers, without expensive nanoparticles

46 research, we expect that various types of G-quadruplex DNA aptasensors capable of specifically sensi

47 the discrimination between duplex DNA and G-quadruplex DNA are necessary to unravel the biological f

48 opper(II) salphen metal complexes bound to a quadruplex DNA are presented.

49 G-Quadruplex DNAs are folded, non-Watson-Crick structures

50 Thus, a minimal synthetic model of G-quadruplex DNA, as in that associated with human gene pr

51 -C70 terminal three-helix bundle binds the G-quadruplex DNA at the interface between helices H1 and H

52 to study binding kinetics of ligands with G-quadruplex DNA at the single molecule level.

53 nium ligands bind tightly and selectively to quadruplex DNAs at low ligand concentration ( approximat

54 incorporating as a stoppering unit a known G-quadruplex DNA binder, namely a Pt(II) -salphen complex.

55 the first example of a reduction-activated G-quadruplex DNA binder.

56 tion (R(2) = 0.81) across the series between quadruplex DNA binding affinity and TRAP inhibition pote

57 Selectivity for quadruplex DNA binding and stabilization by compounds we

58 and evaluation for telomerase-inhibitory and quadruplex DNA binding properties of three related serie

59 ic acid diimide], have different levels of G-quadruplex DNA binding selectivity at pH 7 as determined

60 mM KCl, 1 mM EDTA buffer also demonstrated G-quadruplex DNA binding selectivity under these buffer co

61 pH 6.4, where it demonstrates only modest G-quadruplex DNA binding selectivity, and PIPER in pH 8.5

62 that ligand aggregation is correlated with G-quadruplex DNA binding selectivity.

63 n resonance and fluorescence spectroscopic G-quadruplex DNA binding studies of these T-ag G-quadruple

64 unds retain high affinity to human telomeric quadruplex DNA but are 10-fold more potent against the M

65 PER specifically prevents the unwinding of G-quadruplex DNA but not duplex DNA by Sgs1.

66 istamycin A, and DTC all form complexes with quadruplex DNA, but only Tel01 is completely selective f

67 duplex DNA can be effectively converted to G-quadruplex DNA by a small molecular weight ligand.

68 etal) indicates that the compound binds to G-quadruplex DNA by stacking externally on the 3' G-tetrad

69 druplex and the antiparallel hairpin dimer G-quadruplex DNA by yeast Sgs1 helicase (Sgs1p).

70 and a reduction in the degree to which the G-quadruplex DNA can support DNA-dependent ATPase activity

71 Quadruplex DNAs can fold into a variety of distinct topo

72 mics simulations has been undertaken on four quadruplex-DNA complexes.

73 L1, none of the glycosylases had activity on quadruplex DNA containing 8-oxoG.

74 tinum(II) complexes which, upon binding to G-quadruplex DNA, display an increase in their phosphoresc

75 Because G-quadruplex DNA exhibits structural polymorphism, differe

76 G-quadruplex DNA folds into different topologies that are

77 Targeting G-quadruplex DNAs for cancer treatment is a very promising

78 G-quadruplex DNAs form four-stranded helical structures an

79 .62 A crystal structure of an intramolecular quadruplex DNA formed from a sequence in the promoter re

80 s the possibility that insulin may bind to G-quadruplex DNA formed in the ILPR in vivo and thereby pl

81 moter activity of c-MYC gene that contains G-quadruplex DNA forming sequence in the upstream promoter

82 forming noncanonical triplexes that block G-quadruplex DNA from interacting with transcription facto

83 is required for successful replication of G-quadruplex DNA (G4 DNA) in higher eukaryotes.

84 ecific DNA helicase that dissociates guanine quadruplex DNA (G4 DNA) in vitro.

85 r derivation produced compounds serving as G-quadruplex DNA (G4 DNA) stabilizers.

86 Here, we report that G-quadruplex DNA (G4-DNA) accumulates in neurons, in an ex

87 particularly active in vitro in unwinding G-quadruplex DNA (G4-DNA), a family of non-canonical nucle

88 for small molecules that strongly bind to G-quadruplex-DNA (G4), so-called G4 ligands, has invigorat

89 e-bis(piperazinyl benzimidazole) unit with G-quadruplex DNA (G4DNA) formed by human telomeric repeat

90 guanine-rich sequences that can fold into G-quadruplex DNA (G4DNA).

91 ) based on Troger's base skeleton with the G-quadruplex DNA (G4DNA).

92 NA structures under the larger umbrella of G-quadruplex DNAs (G4s).

93 Moreover, G-quadruplex DNA has been implicated in the alignment of f

94 G-quadruplex DNA has been suggested to regulate DNA replic

95 oth potent and selective inhibitors of the G-quadruplex DNA helicase activity of T-ag.

96 n, the assembly of antibody and alkylthiol/G-quadruplex DNA/hemin on gold nanoparticles was used as b

97 MRX complex, protects rev7Delta cells from G-quadruplex DNA-HU-induced toxicity, and promotes NHEJ by

98 tro experiments support the involvement of G-quadruplex DNA in the binding interaction.

99 ilino side chains as telomeric and genomic G-quadruplex DNA interacting agents are described.

100 Quadruplex DNA interaction was further characterized thr

101 formation about the details of the potassium-quadruplex DNA interactions are of interest.

102 me of these ligands among the most selective quadruplex DNA interactive agents reported to date.

103 derivative, is a very potent and selective G-quadruplex DNA-interactive agent.

104 G-quadruplex DNA is a non-canonical structure that forms i

105 The study of ligand interaction with G-quadruplex DNA is an active research area, because many

106 esion at the site most prone to oxidation in quadruplex DNA is not efficiently removed by NEIL1 or NE

107 The binding of actinomycin D to the G-quadruplex DNAs is characterized by intrinsic associatio

108 eral elements, exhibits strong affinity to G-quadruplex DNA, it displays a much weaker affinity for t

109 ngs on the selectivity of other classes of G-quadruplex DNA ligands is discussed.

110 perylenetetracarboxylic acid diimide-based G-quadruplex DNA ligands, PIPER [N,N'-bis(2-(1-piperidino)

111 op a competitive screening method in which G-quadruplex DNA linked magnetic nanoparticles pull down s

112 As quadruplex DNAs may be important in the structure of tel

113 kinase Aurora A to a greater extent than the quadruplex DNA of a human telomeric sequence.

114 Insulin capture by a G-quadruplex DNA oligonucleotide containing a two-repeat s

115 s significantly more effective in disrupting quadruplex DNA on long telomeric tails than an antisense

116 th diverse nucleic acid scaffolds, such as G-quadruplex DNA or DNA nanoflowers.

117 ingle-chain antibody that is selective for G-quadruplex DNA over double-stranded DNA, and here show t

118 G-quadruplex DNA presents a potential target for the desig

119 clease assay confirmed the ligand mediated G-quadruplex DNA protection.

120 Our results suggest that guanine quadruplex DNAs provoke DNA breaks in PKD1, providing a

121 eviously identified the major tetramolecular quadruplex DNA resolving activity in HeLa cell lysates a

122 G-quadruplex DNA secondary structures (G4s) have recently

123 ement of other epigenomic features such as G-quadruplex DNA secondary structures (G4s).

124 Four-stranded G-quadruplex DNA secondary structures have recently been v

125 Here we report that the less G-quadruplex DNA selective ligand PIPER can unwind double-

126 H 8.5 buffer is both aggregated and highly G-quadruplex DNA-selective.

127 in the development of compounds that bind G-quadruplex DNA selectively has been sparked by the disco

128 This water-soluble complex cleaves G-quadruplex DNA selectively in the presence of dithiothre

129 se conditions display much lower levels of G-quadruplex DNA selectivity.

130 this telomerase inhibitor bound to telomeric quadruplex DNA should help in the design of new anticanc

131 dinium side chains form a promising class of quadruplex DNA stabilizing agents having high selectivit

132 Ligand-induced stabilization of the G-quadruplex DNA structure derived from the single-strande

133 odel for the interaction of Tel01 with the G-quadruplex DNA structure formed by d(TAGGGTTA) was deter

134 oxoguanine, on the transition from duplex to quadruplex DNA structure occurring at nuclease hypersens

135 ons of a number of compounds with a parallel quadruplex DNA structure were simulated by molecular mod

136 ption likely through modulation of a local G-quadruplex DNA structure.

137 LAMP) integrated with peroxidase-mimicking G-quadruplex DNA structures (DNAzyme), termed DNAzyme-LAMP

138 G-quadruplex DNA structures (G4s) form within single-stran

139 abilize the formation of chair- or edge-type quadruplex DNA structures and appears to be the only nat

140 o 10-fold and on bimolecular anti-parallel G-quadruplex DNA structures and three-stranded D-loop appr

141 Here we demonstrate that guanine quadruplex DNA structures are abundant throughout human,

142 Ligands that bind to and stabilize these G-quadruplex DNA structures are potential inhibitors of th

143 cell-cycle progression and that endogenous G-quadruplex DNA structures can be stabilized by a small-m

144 G-quadruplex DNA structures exhibit a profound influence o

145 On the basis of growing evidence for G-quadruplex DNA structures in genomic DNA and the presume

146 We also identified potential G-quadruplex DNA structures in this gene and found that th

147 of d(TTAGGG)n tandem repeats, which can form quadruplex DNA structures in vitro and likely in vivo.

148 Several ILPR variants form G-quadruplex DNA structures in vitro that exhibit affinity

149 (Gh), or spiroiminodihydantoin (Sp) can form quadruplex DNA structures in vitro.

150 gies to explore the therapeutic potential of quadruplex DNA structures is by stabilizing them with sm

151 Various biologically relevant G-quadruplex DNA structures offer a platform for therapeut

152 abilizing agents having high selectivity for quadruplex DNA structures over duplex DNA structures.

153 -oxodG may have a greater tendency to form G-quadruplex DNA structures than telomeric DNA lacking 8-o

154 87) has a higher selectivity for triplex and quadruplex DNA structures than the 3,6,8,11,13-pentameth

155 We also found that TraB binds G-quadruplex DNA structures with higher affinity than TraB

156 to a reduced ability to replicate through G-quadruplex DNA structures, and also loss of sister chrom

157 TAGGG) repeats that are capable of forming G-quadruplex DNA structures.

158 reakpoints prevalent in human disease form G-quadruplex DNA structures.

159 all molecules that can selectively bind to G-quadruplex DNA structures.

160 Pif1 readily unfolds a parallel quadruplex DNA substrate in a multiturnover reaction and

161 of yeast Pif1 to bind and unfold a parallel quadruplex DNA substrate.

162 ase activity to unwinding forked duplex or G-quadruplex DNA substrates or disrupting protein-DNA comp

163 cterized intermolecular and intramolecular G-quadruplex DNA substrates, as well as a unimolecular G4

164 e Mre11-Rad50-Xrs2 (MRX) subunits, impedes G-quadruplex DNA synergized HU-induced toxicity, and facil

165 e conjugate reacts significantly faster with quadruplex DNA (t1/2 = 1.2 h) than with double-stranded

166 rapeutic potential of PARP1 inhibition via G-quadruplex DNA targeting.

167 that Pif1 binds more tightly to the parallel quadruplex DNA than single-stranded DNA or tailed duplex

168 druplex DNA and >25 degrees C for promoter G-quadruplex DNAs) than duplex DNA (DeltaT(m) </= 1.6 degr

169 ibutes in addition to binding affinity for G-quadruplex DNA that may be important for inhibition.

170 and displacement-driven cyclic assembly of G-quadruplex DNA, the development of an enzyme-free and no

171 In promoter G-quadruplex DNA, the NEIL glycosylases primarily remove G

172 etains limited accessibility, of telomeric G-quadruplex DNA to complementary single stranded DNA and

173 found that the exposure of (Br)dU-bearing G-quadruplex DNA to UVA light could also give rise to the

174 er substrates such as replication fork and G-quadruplex DNA, triplex DNA was a preferred substrate fo

175 y offer a route to the specific detection of quadruplex DNA under biologically important conditions.

176 ince then, the number of studies reporting G-quadruplex DNA unfolding by helicase enzymes has rapidly

177 these structures for DNA replication, the G-quadruplex DNA unwinding ability of a prototypical repli

178 quadruplex-interactive agents inhibits the G-quadruplex DNA unwinding activity of T-ag, relative to t

179 -ag, relative to those reported to inhibit G-quadruplex DNA unwinding by RecQ-family helicases.

180 elicase family whose members include other G-quadruplex DNA unwinding helicases, such as human Bloom'

181 targeting ligands is their selectivity for G-quadruplex DNA versus double-stranded DNA structures.

182 eract with and stabilize an intramolecular G-quadruplex DNA was evaluated by surface plasmon resonanc

183 nal effects and dynamics of ion binding to G-quadruplex DNA, we compare results from further experime

184 Although Sp and Gh in quadruplex DNA were good substrates for mNeil3 and NEIL1

185 ydration arrangements around selected folded quadruplex DNAs, which has revealed several prominent fe

186 through end-stacking with guanine tetrads of quadruplex DNA, while distamycin A interacts by binding

187 ibit exquisite selectivity for stabilizing G-quadruplex DNA with no stabilization of duplex DNA or RN

188 undreds of ligands which can interact with G-quadruplex DNA, yet very few which target i-motif.